-- dump date 20140619_103313 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272568000001 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 272568000002 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 272568000003 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568000004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568000005 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272568000006 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568000007 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568000008 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568000009 catalytic residue [active] 272568000010 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 272568000011 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 272568000012 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 272568000013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272568000014 ParA-like protein; Provisional; Region: PHA02518 272568000015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272568000016 P-loop; other site 272568000017 Magnesium ion binding site [ion binding]; other site 272568000018 Replication initiator protein A; Region: RPA; pfam10134 272568000019 Helix-turn-helix domain; Region: HTH_17; pfam12728 272568000020 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272568000021 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 272568000022 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 272568000023 Uncharacterized conserved protein [Function unknown]; Region: COG5489 272568000024 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 272568000025 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568000026 putative C-terminal domain interface [polypeptide binding]; other site 272568000027 putative GSH binding site (G-site) [chemical binding]; other site 272568000028 putative dimer interface [polypeptide binding]; other site 272568000029 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 272568000030 putative N-terminal domain interface [polypeptide binding]; other site 272568000031 putative dimer interface [polypeptide binding]; other site 272568000032 putative substrate binding pocket (H-site) [chemical binding]; other site 272568000033 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 272568000034 Domain of unknown function (DUF932); Region: DUF932; cl12129 272568000035 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272568000036 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272568000037 catalytic residues [active] 272568000038 catalytic nucleophile [active] 272568000039 Presynaptic Site I dimer interface [polypeptide binding]; other site 272568000040 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272568000041 Synaptic Flat tetramer interface [polypeptide binding]; other site 272568000042 Synaptic Site I dimer interface [polypeptide binding]; other site 272568000043 DNA binding site [nucleotide binding] 272568000044 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272568000045 DNA-binding interface [nucleotide binding]; DNA binding site 272568000046 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 272568000047 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 272568000048 active site 272568000049 metal binding site [ion binding]; metal-binding site 272568000050 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 272568000051 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272568000052 active site 272568000053 substrate binding site [chemical binding]; other site 272568000054 Mg2+ binding site [ion binding]; other site 272568000055 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272568000056 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 272568000057 VirB7 interaction site; other site 272568000058 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 272568000059 AAA-like domain; Region: AAA_10; pfam12846 272568000060 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 272568000061 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272568000062 Walker A motif; other site 272568000063 ATP binding site [chemical binding]; other site 272568000064 Walker B motif; other site 272568000065 AAA-like domain; Region: AAA_10; pfam12846 272568000066 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272568000067 Walker A motif; other site 272568000068 ATP binding site [chemical binding]; other site 272568000069 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 272568000070 Walker B motif; other site 272568000071 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272568000072 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272568000073 P-loop; other site 272568000074 Magnesium ion binding site [ion binding]; other site 272568000075 conjugal transfer protein TraL; Provisional; Region: PRK13886 272568000076 Replication protein C N-terminal domain; Region: RP-C; pfam03428 272568000077 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 272568000078 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568000079 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568000080 TrbM; Region: TrbM; pfam07424 272568000081 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272568000082 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272568000083 dimer interface [polypeptide binding]; other site 272568000084 ssDNA binding site [nucleotide binding]; other site 272568000085 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272568000087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568000088 sequence-specific DNA binding site [nucleotide binding]; other site 272568000089 salt bridge; other site 272568000090 Restriction endonuclease; Region: Mrr_cat; pfam04471 272568000091 TIR domain; Region: TIR_2; cl17458 272568000092 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 272568000093 5' RNA guide strand anchoring site; other site 272568000094 active site 272568000097 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568000098 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568000099 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568000101 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568000102 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568000103 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568000104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568000105 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568000106 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568000107 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568000108 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568000109 Transposase domain (DUF772); Region: DUF772; pfam05598 272568000110 DDE superfamily endonuclease; Region: DDE_4; cl17710 272568000111 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568000112 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568000113 Major royal jelly protein; Region: MRJP; pfam03022 272568000114 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 272568000115 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272568000116 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272568000117 shikimate binding site; other site 272568000118 NAD(P) binding site [chemical binding]; other site 272568000119 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 272568000120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000121 putative substrate translocation pore; other site 272568000122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000123 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 272568000124 ATP-NAD kinase; Region: NAD_kinase; pfam01513 272568000125 nitrilase; Region: PLN02798 272568000126 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 272568000127 putative active site [active] 272568000128 catalytic triad [active] 272568000129 dimer interface [polypeptide binding]; other site 272568000130 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272568000131 Cation efflux family; Region: Cation_efflux; pfam01545 272568000132 phosphoserine phosphatase SerB; Region: serB; TIGR00338 272568000133 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272568000134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568000135 motif II; other site 272568000136 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272568000137 IPP transferase; Region: IPPT; pfam01715 272568000138 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 272568000139 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272568000140 PYR/PP interface [polypeptide binding]; other site 272568000141 dimer interface [polypeptide binding]; other site 272568000142 TPP binding site [chemical binding]; other site 272568000143 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272568000144 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272568000145 TPP-binding site [chemical binding]; other site 272568000146 dimer interface [polypeptide binding]; other site 272568000147 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272568000148 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272568000149 putative valine binding site [chemical binding]; other site 272568000150 dimer interface [polypeptide binding]; other site 272568000151 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272568000152 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272568000153 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272568000154 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272568000158 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272568000159 MULE transposase domain; Region: MULE; pfam10551 272568000160 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272568000161 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272568000162 catalytic residues [active] 272568000163 catalytic nucleophile [active] 272568000164 Recombinase; Region: Recombinase; pfam07508 272568000165 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272568000166 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272568000167 DNA binding residues [nucleotide binding] 272568000168 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 272568000169 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 272568000170 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 272568000171 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 272568000172 homodimer interface [polypeptide binding]; other site 272568000173 Walker A motif; other site 272568000174 ATP binding site [chemical binding]; other site 272568000175 hydroxycobalamin binding site [chemical binding]; other site 272568000176 Walker B motif; other site 272568000177 cobyric acid synthase; Provisional; Region: PRK00784 272568000178 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272568000179 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272568000180 catalytic triad [active] 272568000181 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568000182 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 272568000183 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568000184 catalytic residue [active] 272568000185 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 272568000186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000187 putative sialic acid transporter; Region: 2A0112; TIGR00891 272568000188 putative substrate translocation pore; other site 272568000189 Fusaric acid resistance protein family; Region: FUSC; pfam04632 272568000190 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272568000191 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 272568000192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568000193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000194 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272568000195 dimerization interface [polypeptide binding]; other site 272568000196 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272568000197 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272568000198 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272568000199 ligand binding site [chemical binding]; other site 272568000200 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 272568000201 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272568000202 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272568000203 Catalytic dyad [active] 272568000204 Kinase-interacting domains of the HopAB family of Type III Effector proteins; Region: HopAB_KID; cl17109 272568000205 kinase binding site [polypeptide binding]; other site 272568000206 ribonuclease R; Region: RNase_R; TIGR02063 272568000207 RNB domain; Region: RNB; pfam00773 272568000208 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272568000209 RNA binding site [nucleotide binding]; other site 272568000210 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 272568000211 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272568000212 active site 272568000213 interdomain interaction site; other site 272568000214 putative metal-binding site [ion binding]; other site 272568000215 nucleotide binding site [chemical binding]; other site 272568000216 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272568000217 domain I; other site 272568000218 DNA binding groove [nucleotide binding] 272568000219 phosphate binding site [ion binding]; other site 272568000220 domain II; other site 272568000221 domain III; other site 272568000222 nucleotide binding site [chemical binding]; other site 272568000223 catalytic site [active] 272568000224 domain IV; other site 272568000225 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272568000226 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272568000227 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272568000228 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 272568000229 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272568000230 DNA protecting protein DprA; Region: dprA; TIGR00732 272568000231 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272568000232 dihydroorotase; Validated; Region: pyrC; PRK09357 272568000233 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568000234 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272568000235 active site 272568000236 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272568000237 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272568000238 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272568000239 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272568000240 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272568000241 HIGH motif; other site 272568000242 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272568000243 active site 272568000244 KMSKS motif; other site 272568000245 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272568000246 Competence protein; Region: Competence; pfam03772 272568000247 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272568000248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272568000249 minor groove reading motif; other site 272568000250 helix-hairpin-helix signature motif; other site 272568000251 substrate binding pocket [chemical binding]; other site 272568000252 active site 272568000253 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 272568000254 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272568000255 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272568000256 Walker A/P-loop; other site 272568000257 ATP binding site [chemical binding]; other site 272568000258 Q-loop/lid; other site 272568000259 ABC transporter signature motif; other site 272568000260 Walker B; other site 272568000261 D-loop; other site 272568000262 H-loop/switch region; other site 272568000264 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 272568000265 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 272568000266 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 272568000267 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 272568000268 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 272568000269 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 272568000270 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 272568000271 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 272568000272 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272568000273 oligomeric interface; other site 272568000274 putative active site [active] 272568000275 homodimer interface [polypeptide binding]; other site 272568000276 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 272568000277 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 272568000278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272568000279 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 272568000280 nucleotide binding site/active site [active] 272568000281 HIT family signature motif; other site 272568000282 catalytic residue [active] 272568000283 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272568000284 metal binding site [ion binding]; metal-binding site 272568000285 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272568000286 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272568000287 substrate binding site [chemical binding]; other site 272568000288 glutamase interaction surface [polypeptide binding]; other site 272568000289 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272568000290 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272568000291 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272568000292 catalytic residues [active] 272568000293 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 272568000294 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272568000295 putative active site [active] 272568000296 oxyanion strand; other site 272568000297 catalytic triad [active] 272568000298 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272568000299 putative active site pocket [active] 272568000300 4-fold oligomerization interface [polypeptide binding]; other site 272568000301 metal binding residues [ion binding]; metal-binding site 272568000302 3-fold/trimer interface [polypeptide binding]; other site 272568000303 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 272568000304 putative FMN binding site [chemical binding]; other site 272568000305 hypothetical protein; Provisional; Region: PRK09126 272568000306 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272568000309 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 272568000310 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 272568000311 tetramer interface [polypeptide binding]; other site 272568000312 heme binding pocket [chemical binding]; other site 272568000313 NADPH binding site [chemical binding]; other site 272568000314 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 272568000315 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 272568000316 NAD(P) binding site [chemical binding]; other site 272568000317 catalytic residues [active] 272568000318 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272568000319 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272568000320 TAP-like protein; Region: Abhydrolase_4; pfam08386 272568000321 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 272568000322 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272568000323 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 272568000324 putative active site [active] 272568000325 putative FMN binding site [chemical binding]; other site 272568000326 putative substrate binding site [chemical binding]; other site 272568000327 putative catalytic residue [active] 272568000328 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272568000329 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272568000330 DNA binding residues [nucleotide binding] 272568000331 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 272568000332 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272568000333 potential catalytic triad [active] 272568000334 conserved cys residue [active] 272568000335 Toprim domain; Region: Toprim_3; pfam13362 272568000336 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 272568000337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272568000338 non-specific DNA binding site [nucleotide binding]; other site 272568000339 salt bridge; other site 272568000340 sequence-specific DNA binding site [nucleotide binding]; other site 272568000341 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 272568000342 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 272568000343 Uncharacterized conserved protein [Function unknown]; Region: COG2135 272568000344 Uncharacterized conserved protein [Function unknown]; Region: COG4544 272568000345 DNA Polymerase Y-family; Region: PolY_like; cd03468 272568000346 active site 272568000347 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272568000348 DNA binding site [nucleotide binding] 272568000349 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 272568000350 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 272568000351 putative active site [active] 272568000352 putative PHP Thumb interface [polypeptide binding]; other site 272568000353 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272568000354 generic binding surface I; other site 272568000355 generic binding surface II; other site 272568000356 Helix-turn-helix domain; Region: HTH_17; pfam12728 272568000357 Replication initiator protein A; Region: RPA; pfam10134 272568000358 ParA-like protein; Provisional; Region: PHA02518 272568000359 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272568000360 P-loop; other site 272568000361 Magnesium ion binding site [ion binding]; other site 272568000362 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272568000363 DNA methylase; Region: N6_N4_Mtase; pfam01555 272568000364 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 272568000365 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 272568000366 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 272568000367 Protein of unknown function (DUF736); Region: DUF736; pfam05284 272568000368 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568000369 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568000370 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568000371 catalytic residue [active] 272568000374 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568000375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568000376 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 272568000377 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 272568000378 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 272568000379 AAA domain; Region: AAA_13; pfam13166 272568000380 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272568000381 active site 272568000382 metal binding site [ion binding]; metal-binding site 272568000383 DNA binding site [nucleotide binding] 272568000384 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272568000385 AAA domain; Region: AAA_27; pfam13514 272568000386 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 272568000387 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 272568000388 ThiF family; Region: ThiF; pfam00899 272568000389 ATP binding site [chemical binding]; other site 272568000390 substrate interface [chemical binding]; other site 272568000391 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 272568000392 active site 272568000393 NTP binding site [chemical binding]; other site 272568000394 metal binding triad [ion binding]; metal-binding site 272568000395 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 272568000396 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 272568000397 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272568000398 Walker A motif; other site 272568000399 ATP binding site [chemical binding]; other site 272568000400 Walker B motif; other site 272568000401 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 272568000402 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 272568000403 ATP binding site [chemical binding]; other site 272568000404 Walker A motif; other site 272568000405 hexamer interface [polypeptide binding]; other site 272568000406 Walker B motif; other site 272568000407 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 272568000408 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 272568000409 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 272568000410 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 272568000411 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 272568000412 conjugal transfer protein TrbL; Provisional; Region: PRK13875 272568000413 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 272568000414 conjugal transfer protein TrbF; Provisional; Region: PRK13872 272568000415 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 272568000416 VirB7 interaction site; other site 272568000417 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272568000418 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272568000419 dimerization interface [polypeptide binding]; other site 272568000420 substrate binding pocket [chemical binding]; other site 272568000421 Transposase; Region: HTH_Tnp_1; pfam01527 272568000422 putative transposase OrfB; Reviewed; Region: PHA02517 272568000423 HTH-like domain; Region: HTH_21; pfam13276 272568000424 Integrase core domain; Region: rve; pfam00665 272568000425 Integrase core domain; Region: rve_3; pfam13683 272568000426 multidrug efflux protein; Reviewed; Region: PRK09579 272568000427 Protein export membrane protein; Region: SecD_SecF; cl14618 272568000428 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272568000429 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568000430 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568000431 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568000432 Helix-turn-helix domain; Region: HTH_20; pfam12840 272568000433 dimerization interface [polypeptide binding]; other site 272568000434 putative DNA binding site [nucleotide binding]; other site 272568000435 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 272568000436 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 272568000437 catalytic residues [active] 272568000438 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 272568000439 Serine hydrolase (FSH1); Region: FSH1; pfam03959 272568000440 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 272568000441 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 272568000442 Transposase; Region: HTH_Tnp_1; pfam01527 272568000443 putative transposase OrfB; Reviewed; Region: PHA02517 272568000444 HTH-like domain; Region: HTH_21; pfam13276 272568000445 Integrase core domain; Region: rve; pfam00665 272568000446 Integrase core domain; Region: rve_3; pfam13683 272568000448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568000449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568000451 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 272568000452 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 272568000453 NADP binding site [chemical binding]; other site 272568000454 dimer interface [polypeptide binding]; other site 272568000455 Predicted transcriptional regulator [Transcription]; Region: COG2932 272568000456 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272568000457 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272568000458 HflX GTPase family; Region: HflX; cd01878 272568000459 G1 box; other site 272568000460 GTP/Mg2+ binding site [chemical binding]; other site 272568000461 Switch I region; other site 272568000462 G2 box; other site 272568000463 G3 box; other site 272568000464 Switch II region; other site 272568000465 G4 box; other site 272568000466 G5 box; other site 272568000467 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568000468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568000469 metal binding site [ion binding]; metal-binding site 272568000470 active site 272568000471 I-site; other site 272568000472 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 272568000473 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 272568000474 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 272568000475 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 272568000476 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272568000477 active site 272568000478 SAM binding site [chemical binding]; other site 272568000479 homodimer interface [polypeptide binding]; other site 272568000480 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 272568000481 Walker A motif; other site 272568000482 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 272568000483 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 272568000484 GTP binding site; other site 272568000485 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 272568000486 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 272568000487 DNA binding site [nucleotide binding] 272568000488 heterodimer interface [polypeptide binding]; other site 272568000489 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 272568000490 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 272568000491 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 272568000492 active site 272568000493 DNA binding site [nucleotide binding] 272568000494 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 272568000495 DNA binding site [nucleotide binding] 272568000496 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 272568000497 nucleotide binding site [chemical binding]; other site 272568000498 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 272568000499 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 272568000500 putative DNA binding site [nucleotide binding]; other site 272568000501 putative homodimer interface [polypeptide binding]; other site 272568000502 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 272568000503 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 272568000504 dimer interface [polypeptide binding]; other site 272568000505 PYR/PP interface [polypeptide binding]; other site 272568000506 TPP binding site [chemical binding]; other site 272568000507 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272568000508 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 272568000509 TPP-binding site [chemical binding]; other site 272568000510 dimer interface [polypeptide binding]; other site 272568000511 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 272568000512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000513 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 272568000514 putative dimerization interface [polypeptide binding]; other site 272568000515 putative substrate binding pocket [chemical binding]; other site 272568000516 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 272568000517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 272568000518 Uncharacterized conserved protein [Function unknown]; Region: COG2308 272568000519 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272568000520 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272568000521 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272568000522 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 272568000523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 272568000524 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 272568000525 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 272568000526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 272568000527 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 272568000528 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272568000529 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272568000530 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272568000531 pantoate--beta-alanine ligase; Region: panC; TIGR00018 272568000532 Pantoate-beta-alanine ligase; Region: PanC; cd00560 272568000533 active site 272568000534 ATP-binding site [chemical binding]; other site 272568000535 pantoate-binding site; other site 272568000536 HXXH motif; other site 272568000537 Uncharacterized conserved protein [Function unknown]; Region: COG2835 272568000538 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 272568000539 Found in ATP-dependent protease La (LON); Region: LON; smart00464 272568000540 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 272568000541 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 272568000542 Predicted transcriptional regulators [Transcription]; Region: COG1733 272568000543 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272568000544 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272568000545 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272568000546 putative NAD(P) binding site [chemical binding]; other site 272568000547 dimer interface [polypeptide binding]; other site 272568000548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568000549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000550 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272568000551 dimerization interface [polypeptide binding]; other site 272568000552 hypothetical protein; Provisional; Region: PRK05463 272568000553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000554 D-galactonate transporter; Region: 2A0114; TIGR00893 272568000555 putative substrate translocation pore; other site 272568000556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000557 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568000558 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568000559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000560 metabolite-proton symporter; Region: 2A0106; TIGR00883 272568000561 putative substrate translocation pore; other site 272568000562 hypothetical protein; Validated; Region: PRK06201 272568000563 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 272568000564 transcriptional regulator, ArgP family; Region: argP; TIGR03298 272568000565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272568000567 dimerization interface [polypeptide binding]; other site 272568000568 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272568000569 Amidase; Region: Amidase; cl11426 272568000570 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 272568000571 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 272568000572 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 272568000573 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 272568000574 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 272568000575 MarR family; Region: MarR_2; cl17246 272568000576 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 272568000577 lipoyl-biotinyl attachment site [posttranslational modification]; other site 272568000578 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272568000579 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272568000580 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272568000581 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272568000582 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272568000583 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272568000584 carboxyltransferase (CT) interaction site; other site 272568000585 biotinylation site [posttranslational modification]; other site 272568000586 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 272568000587 putative active site [active] 272568000588 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 272568000589 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 272568000590 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 272568000591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000592 D-galactonate transporter; Region: 2A0114; TIGR00893 272568000593 putative substrate translocation pore; other site 272568000594 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568000595 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568000596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568000597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000598 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 272568000599 putative dimerization interface [polypeptide binding]; other site 272568000600 allantoate amidohydrolase; Reviewed; Region: PRK12890 272568000601 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272568000602 active site 272568000603 metal binding site [ion binding]; metal-binding site 272568000604 dimer interface [polypeptide binding]; other site 272568000605 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 272568000606 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 272568000607 putative active site [active] 272568000608 putative metal binding site [ion binding]; other site 272568000609 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272568000610 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 272568000611 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272568000612 ligand binding site [chemical binding]; other site 272568000613 NAD binding site [chemical binding]; other site 272568000614 dimerization interface [polypeptide binding]; other site 272568000615 catalytic site [active] 272568000616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 272568000617 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568000618 putative metal binding site [ion binding]; other site 272568000619 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 272568000620 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 272568000621 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272568000622 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272568000623 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272568000624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568000625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000626 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568000627 putative effector binding pocket; other site 272568000628 dimerization interface [polypeptide binding]; other site 272568000629 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272568000630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568000632 dimerization interface [polypeptide binding]; other site 272568000633 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 272568000634 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 272568000635 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 272568000636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568000637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568000639 dimerization interface [polypeptide binding]; other site 272568000640 short chain dehydrogenase; Provisional; Region: PRK06500 272568000641 classical (c) SDRs; Region: SDR_c; cd05233 272568000642 NAD(P) binding site [chemical binding]; other site 272568000643 active site 272568000644 Winged helix-turn helix; Region: HTH_29; pfam13551 272568000645 Integrase core domain; Region: rve; pfam00665 272568000646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568000647 Integrase core domain; Region: rve_3; pfam13683 272568000648 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272568000649 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 272568000650 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 272568000651 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 272568000652 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 272568000653 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272568000654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568000655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568000656 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272568000657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568000658 NAD(P) binding site [chemical binding]; other site 272568000659 active site 272568000660 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272568000661 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 272568000662 FMN binding site [chemical binding]; other site 272568000663 active site 272568000664 substrate binding site [chemical binding]; other site 272568000665 catalytic residue [active] 272568000666 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272568000667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568000668 active site 272568000669 phosphorylation site [posttranslational modification] 272568000670 intermolecular recognition site; other site 272568000671 dimerization interface [polypeptide binding]; other site 272568000672 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272568000673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000674 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272568000675 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568000676 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568000677 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568000678 Pirin-related protein [General function prediction only]; Region: COG1741 272568000679 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272568000680 TPP-binding site [chemical binding]; other site 272568000681 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 272568000682 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272568000683 PYR/PP interface [polypeptide binding]; other site 272568000684 dimer interface [polypeptide binding]; other site 272568000685 TPP binding site [chemical binding]; other site 272568000686 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272568000687 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568000689 Flagellin N-methylase; Region: FliB; cl00497 272568000690 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272568000691 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 272568000692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272568000693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568000694 dimer interface [polypeptide binding]; other site 272568000695 conserved gate region; other site 272568000696 putative PBP binding loops; other site 272568000697 ABC-ATPase subunit interface; other site 272568000698 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272568000699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568000700 dimer interface [polypeptide binding]; other site 272568000701 conserved gate region; other site 272568000702 putative PBP binding loops; other site 272568000703 ABC-ATPase subunit interface; other site 272568000704 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272568000705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272568000706 Walker A/P-loop; other site 272568000707 ATP binding site [chemical binding]; other site 272568000708 Q-loop/lid; other site 272568000709 ABC transporter signature motif; other site 272568000710 Walker B; other site 272568000711 D-loop; other site 272568000712 H-loop/switch region; other site 272568000713 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272568000714 Walker A/P-loop; other site 272568000715 ATP binding site [chemical binding]; other site 272568000716 Q-loop/lid; other site 272568000717 ABC transporter signature motif; other site 272568000718 Walker B; other site 272568000719 D-loop; other site 272568000720 H-loop/switch region; other site 272568000721 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272568000722 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 272568000723 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272568000724 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 272568000725 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 272568000726 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 272568000727 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568000728 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568000729 Response regulator receiver domain; Region: Response_reg; pfam00072 272568000730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568000731 active site 272568000732 phosphorylation site [posttranslational modification] 272568000733 intermolecular recognition site; other site 272568000734 dimerization interface [polypeptide binding]; other site 272568000735 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272568000736 GAF domain; Region: GAF; pfam01590 272568000737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272568000738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568000739 dimer interface [polypeptide binding]; other site 272568000740 phosphorylation site [posttranslational modification] 272568000741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568000742 ATP binding site [chemical binding]; other site 272568000743 Mg2+ binding site [ion binding]; other site 272568000744 G-X-G motif; other site 272568000745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568000746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568000748 dimerization interface [polypeptide binding]; other site 272568000749 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 272568000750 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272568000751 NAD(P) binding site [chemical binding]; other site 272568000752 active site 272568000753 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 272568000754 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272568000755 putative NAD(P) binding site [chemical binding]; other site 272568000756 substrate binding site [chemical binding]; other site 272568000757 short chain dehydrogenase; Provisional; Region: PRK06500 272568000758 classical (c) SDRs; Region: SDR_c; cd05233 272568000759 NAD(P) binding site [chemical binding]; other site 272568000760 active site 272568000761 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 272568000762 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 272568000763 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272568000764 DAK2 domain; Region: Dak2; cl03685 272568000765 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 272568000766 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272568000767 regulatory protein interface [polypeptide binding]; other site 272568000768 active site 272568000769 regulatory phosphorylation site [posttranslational modification]; other site 272568000770 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272568000771 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272568000772 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272568000773 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272568000774 glycerol kinase; Provisional; Region: glpK; PRK00047 272568000775 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 272568000776 N- and C-terminal domain interface [polypeptide binding]; other site 272568000777 active site 272568000778 MgATP binding site [chemical binding]; other site 272568000779 catalytic site [active] 272568000780 metal binding site [ion binding]; metal-binding site 272568000781 putative homotetramer interface [polypeptide binding]; other site 272568000782 glycerol binding site [chemical binding]; other site 272568000783 homodimer interface [polypeptide binding]; other site 272568000784 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272568000785 amphipathic channel; other site 272568000786 Asn-Pro-Ala signature motifs; other site 272568000787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568000788 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272568000789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568000790 dimerization interface [polypeptide binding]; other site 272568000791 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 272568000792 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568000793 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 272568000794 Methylamine utilisation protein MauE; Region: MauE; pfam07291 272568000795 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568000796 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272568000797 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 272568000798 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272568000799 inhibitor-cofactor binding pocket; inhibition site 272568000800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568000801 catalytic residue [active] 272568000802 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568000803 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272568000804 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 272568000805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568000806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568000807 homodimer interface [polypeptide binding]; other site 272568000808 catalytic residue [active] 272568000809 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272568000810 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272568000811 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272568000813 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272568000814 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272568000815 TPP-binding site [chemical binding]; other site 272568000816 dimer interface [polypeptide binding]; other site 272568000817 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272568000818 PYR/PP interface [polypeptide binding]; other site 272568000819 dimer interface [polypeptide binding]; other site 272568000820 TPP binding site [chemical binding]; other site 272568000821 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272568000822 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 272568000823 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 272568000824 putative active site [active] 272568000825 catalytic residue [active] 272568000826 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272568000827 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272568000828 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272568000829 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 272568000830 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272568000831 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272568000832 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272568000833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568000834 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272568000835 active site 272568000836 motif I; other site 272568000837 motif II; other site 272568000838 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272568000839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568000840 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272568000841 active site 272568000842 motif I; other site 272568000843 motif II; other site 272568000844 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272568000845 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272568000846 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 272568000847 putative active site [active] 272568000848 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272568000849 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272568000850 active site 272568000851 dimer interface [polypeptide binding]; other site 272568000852 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 272568000853 AAA domain; Region: AAA_33; pfam13671 272568000854 ATP-binding site [chemical binding]; other site 272568000855 Gluconate-6-phosphate binding site [chemical binding]; other site 272568000856 transcriptional regulator; interrupted by transposase 272568000857 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568000858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568000859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 272568000860 Homeodomain-like domain; Region: HTH_23; pfam13384 272568000861 Homeodomain-like domain; Region: HTH_32; pfam13565 272568000862 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568000863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568000864 metal binding site [ion binding]; metal-binding site 272568000865 active site 272568000866 I-site; other site 272568000867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568000868 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568000869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568000870 Winged helix-turn helix; Region: HTH_29; pfam13551 272568000871 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568000872 Integrase core domain; Region: rve; pfam00665 272568000873 Integrase core domain; Region: rve_3; pfam13683 272568000874 Winged helix-turn helix; Region: HTH_29; pfam13551 272568000875 Winged helix-turn helix; Region: HTH_33; pfam13592 272568000877 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 272568000878 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272568000879 oligomeric interface; other site 272568000880 putative active site [active] 272568000881 homodimer interface [polypeptide binding]; other site 272568000882 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 272568000883 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272568000884 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 272568000885 phosphate binding site [ion binding]; other site 272568000886 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 272568000887 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 272568000888 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 272568000889 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272568000890 NAD(P) binding site [chemical binding]; other site 272568000891 catalytic residues [active] 272568000892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272568000893 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568000894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568000895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568000896 Homeodomain-like domain; Region: HTH_23; pfam13384 272568000897 Winged helix-turn helix; Region: HTH_29; pfam13551 272568000898 Homeodomain-like domain; Region: HTH_32; pfam13565 272568000899 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568000900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568000901 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272568000902 SPFH domain / Band 7 family; Region: Band_7; pfam01145 272568000903 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272568000904 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272568000905 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 272568000906 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272568000907 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272568000908 DNA binding site [nucleotide binding] 272568000909 domain linker motif; other site 272568000910 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 272568000911 putative ligand binding site [chemical binding]; other site 272568000912 putative dimerization interface [polypeptide binding]; other site 272568000913 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272568000914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272568000915 substrate binding site [chemical binding]; other site 272568000916 oxyanion hole (OAH) forming residues; other site 272568000917 trimer interface [polypeptide binding]; other site 272568000918 choline dehydrogenase; Validated; Region: PRK02106 272568000919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568000920 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272568000921 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 272568000922 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272568000923 ligand binding site [chemical binding]; other site 272568000924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568000925 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272568000926 active site 272568000927 metal binding site [ion binding]; metal-binding site 272568000928 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 272568000929 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 272568000930 Trp docking motif [polypeptide binding]; other site 272568000931 putative active site [active] 272568000932 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 272568000933 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272568000934 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 272568000935 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272568000936 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272568000937 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272568000938 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568000939 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568000940 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 272568000941 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 272568000942 putative active site [active] 272568000943 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568000944 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568000945 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568000946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568000947 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272568000948 active site 272568000949 metal binding site [ion binding]; metal-binding site 272568000950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568000952 putative substrate translocation pore; other site 272568000953 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272568000954 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 272568000955 transmembrane helices; other site 272568000956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000957 D-galactonate transporter; Region: 2A0114; TIGR00893 272568000958 putative substrate translocation pore; other site 272568000959 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272568000960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568000961 non-specific DNA binding site [nucleotide binding]; other site 272568000962 salt bridge; other site 272568000963 sequence-specific DNA binding site [nucleotide binding]; other site 272568000964 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 272568000965 Fatty acid desaturase; Region: FA_desaturase; pfam00487 272568000966 putative di-iron ligands [ion binding]; other site 272568000967 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 272568000968 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272568000969 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 272568000970 active site 272568000971 FMN binding site [chemical binding]; other site 272568000972 substrate binding site [chemical binding]; other site 272568000973 homotetramer interface [polypeptide binding]; other site 272568000974 catalytic residue [active] 272568000975 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 272568000976 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 272568000977 ligand binding site [chemical binding]; other site 272568000978 homodimer interface [polypeptide binding]; other site 272568000979 NAD(P) binding site [chemical binding]; other site 272568000980 trimer interface B [polypeptide binding]; other site 272568000981 trimer interface A [polypeptide binding]; other site 272568000982 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 272568000983 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 272568000984 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 272568000985 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 272568000986 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 272568000987 NAD(P) binding site [chemical binding]; other site 272568000988 catalytic residues [active] 272568000989 citrate-proton symporter; Provisional; Region: PRK15075 272568000990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000991 putative substrate translocation pore; other site 272568000992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272568000993 Isochorismatase family; Region: Isochorismatase; pfam00857 272568000994 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272568000995 catalytic triad [active] 272568000996 conserved cis-peptide bond; other site 272568000997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568000998 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272568000999 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272568001000 DNA binding site [nucleotide binding] 272568001001 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 272568001002 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272568001003 putative ligand binding site [chemical binding]; other site 272568001004 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 272568001005 short chain dehydrogenase; Provisional; Region: PRK06198 272568001006 classical (c) SDRs; Region: SDR_c; cd05233 272568001007 NAD(P) binding site [chemical binding]; other site 272568001008 active site 272568001009 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272568001010 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272568001011 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272568001012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272568001013 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 272568001014 putative ligand binding site [chemical binding]; other site 272568001015 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 272568001016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568001017 Walker A/P-loop; other site 272568001018 ATP binding site [chemical binding]; other site 272568001019 Q-loop/lid; other site 272568001020 ABC transporter signature motif; other site 272568001021 Walker B; other site 272568001022 D-loop; other site 272568001023 H-loop/switch region; other site 272568001024 Winged helix-turn helix; Region: HTH_29; pfam13551 272568001025 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568001026 Integrase core domain; Region: rve; pfam00665 272568001027 Integrase core domain; Region: rve_3; pfam13683 272568001028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568001029 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568001030 TM-ABC transporter signature motif; other site 272568001031 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272568001032 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272568001033 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272568001034 putative active site [active] 272568001035 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272568001036 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272568001037 substrate binding site [chemical binding]; other site 272568001038 ATP binding site [chemical binding]; other site 272568001039 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 272568001040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 272568001041 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 272568001042 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272568001043 dimer interface [polypeptide binding]; other site 272568001044 PYR/PP interface [polypeptide binding]; other site 272568001045 TPP binding site [chemical binding]; other site 272568001046 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272568001047 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 272568001048 TPP-binding site; other site 272568001049 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272568001050 KduI/IolB family; Region: KduI; pfam04962 272568001051 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 272568001052 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 272568001053 tetrameric interface [polypeptide binding]; other site 272568001054 NAD binding site [chemical binding]; other site 272568001055 catalytic residues [active] 272568001056 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272568001057 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272568001058 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272568001059 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 272568001062 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 272568001063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568001064 non-specific DNA binding site [nucleotide binding]; other site 272568001065 salt bridge; other site 272568001066 sequence-specific DNA binding site [nucleotide binding]; other site 272568001067 Winged helix-turn helix; Region: HTH_29; pfam13551 272568001068 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568001069 Integrase core domain; Region: rve; pfam00665 272568001070 Integrase core domain; Region: rve_3; pfam13683 272568001071 Predicted transcriptional regulator [Transcription]; Region: COG2944 272568001072 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568001073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568001074 Winged helix-turn helix; Region: HTH_29; pfam13551 272568001075 Poxvirus C7/F8A protein; Region: Pox_C7_F8A; cl17263 272568001076 putative transposase OrfB; Reviewed; Region: PHA02517 272568001077 HTH-like domain; Region: HTH_21; pfam13276 272568001078 Integrase core domain; Region: rve; pfam00665 272568001079 Integrase core domain; Region: rve_3; pfam13683 272568001080 Transposase; Region: HTH_Tnp_1; pfam01527 272568001081 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272568001082 DNA methylase; Region: N6_N4_Mtase; cl17433 272568001083 Protein of unknown function (DUF736); Region: DUF736; cl02303 272568001084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272568001085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568001086 non-specific DNA binding site [nucleotide binding]; other site 272568001087 salt bridge; other site 272568001088 sequence-specific DNA binding site [nucleotide binding]; other site 272568001089 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 272568001090 Helix-turn-helix domain; Region: HTH_17; pfam12728 272568001091 Replication initiator protein A; Region: RPA; pfam10134 272568001092 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 272568001093 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 272568001094 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 272568001095 Protein of unknown function (DUF736); Region: DUF736; pfam05284 272568001096 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568001097 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568001098 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568001099 catalytic residue [active] 272568001100 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568001101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568001102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272568001103 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 272568001104 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 272568001105 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272568001106 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 272568001107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568001108 Integrase core domain; Region: rve; pfam00665 272568001109 putative transposase OrfB; Reviewed; Region: PHA02517 272568001110 HTH-like domain; Region: HTH_21; pfam13276 272568001111 Integrase core domain; Region: rve; pfam00665 272568001112 Integrase core domain; Region: rve_3; cl15866 272568001114 transposase/IS protein; Provisional; Region: PRK09183 272568001115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568001116 Walker A motif; other site 272568001117 ATP binding site [chemical binding]; other site 272568001118 Walker B motif; other site 272568001119 arginine finger; other site 272568001120 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568001121 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568001122 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568001123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568001124 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 272568001125 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 272568001126 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272568001127 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 272568001128 putative ligand binding site [chemical binding]; other site 272568001129 NAD binding site [chemical binding]; other site 272568001130 dimerization interface [polypeptide binding]; other site 272568001131 catalytic site [active] 272568001132 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272568001133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272568001134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272568001135 Coenzyme A binding pocket [chemical binding]; other site 272568001136 succinic semialdehyde dehydrogenase; Region: PLN02278 272568001137 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272568001138 tetramerization interface [polypeptide binding]; other site 272568001139 NAD(P) binding site [chemical binding]; other site 272568001140 catalytic residues [active] 272568001141 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568001142 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568001143 N-terminal plug; other site 272568001144 ligand-binding site [chemical binding]; other site 272568001145 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 272568001146 tartrate dehydrogenase; Region: TTC; TIGR02089 272568001147 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 272568001148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568001149 putative DNA binding site [nucleotide binding]; other site 272568001150 putative Zn2+ binding site [ion binding]; other site 272568001151 AsnC family; Region: AsnC_trans_reg; pfam01037 272568001152 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272568001153 inhibitor-cofactor binding pocket; inhibition site 272568001154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568001155 catalytic residue [active] 272568001156 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 272568001157 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272568001158 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272568001159 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272568001160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568001161 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 272568001162 Walker A/P-loop; other site 272568001163 ATP binding site [chemical binding]; other site 272568001164 Q-loop/lid; other site 272568001165 ABC transporter signature motif; other site 272568001166 Walker B; other site 272568001167 D-loop; other site 272568001168 H-loop/switch region; other site 272568001169 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272568001170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568001171 dimer interface [polypeptide binding]; other site 272568001172 conserved gate region; other site 272568001173 putative PBP binding loops; other site 272568001174 ABC-ATPase subunit interface; other site 272568001175 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272568001176 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272568001177 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 272568001178 Nif-specific regulatory protein; Region: nifA; TIGR01817 272568001179 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272568001180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568001181 Walker A motif; other site 272568001182 ATP binding site [chemical binding]; other site 272568001183 Walker B motif; other site 272568001184 arginine finger; other site 272568001185 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272568001186 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 272568001187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568001188 FeS/SAM binding site; other site 272568001189 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 272568001190 hypothetical protein; Provisional; Region: PRK13795 272568001191 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 272568001192 NifZ domain; Region: NifZ; pfam04319 272568001193 NifT/FixU protein; Region: NifT; pfam06988 272568001194 SIR2-like domain; Region: SIR2_2; pfam13289 272568001195 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 272568001196 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 272568001197 Nucleotide-binding sites [chemical binding]; other site 272568001198 Walker A motif; other site 272568001199 Switch I region of nucleotide binding site; other site 272568001200 Fe4S4 binding sites [ion binding]; other site 272568001201 Switch II region of nucleotide binding site; other site 272568001202 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272568001203 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 272568001204 MoFe protein alpha/beta subunit interactions; other site 272568001205 Alpha subunit P cluster binding residues; other site 272568001206 FeMoco binding residues [chemical binding]; other site 272568001207 MoFe protein alpha subunit/Fe protein contacts; other site 272568001208 MoFe protein dimer/ dimer interactions; other site 272568001209 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 272568001210 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 272568001211 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 272568001212 MoFe protein beta/alpha subunit interactions; other site 272568001213 Beta subunit P cluster binding residues; other site 272568001214 MoFe protein beta subunit/Fe protein contacts; other site 272568001215 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 272568001216 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 272568001217 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 272568001218 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 272568001219 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 272568001220 probable nitrogen fixation protein; Region: TIGR02935 272568001221 Rop-like; Region: Rop-like; pfam05082 272568001222 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 272568001223 NifQ; Region: NifQ; pfam04891 272568001224 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 272568001225 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 272568001226 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272568001227 trimerization site [polypeptide binding]; other site 272568001228 active site 272568001229 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272568001230 NifU-like domain; Region: NifU; pfam01106 272568001231 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272568001232 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272568001233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568001234 catalytic residue [active] 272568001235 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 272568001236 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 272568001237 active site 272568001238 catalytic residues [active] 272568001239 metal binding site [ion binding]; metal-binding site 272568001240 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 272568001241 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272568001242 Ligand binding site [chemical binding]; other site 272568001243 Electron transfer flavoprotein domain; Region: ETF; pfam01012 272568001244 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 272568001245 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272568001246 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272568001247 oxidoreductase; Provisional; Region: PRK10015 272568001248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272568001249 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 272568001250 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 272568001251 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 272568001252 dimerization interface [polypeptide binding]; other site 272568001253 active site 272568001254 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 272568001255 heme-binding site [chemical binding]; other site 272568001256 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272568001257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568001258 dimer interface [polypeptide binding]; other site 272568001259 putative CheW interface [polypeptide binding]; other site 272568001260 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568001261 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568001262 active site 272568001263 catalytic tetrad [active] 272568001264 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272568001265 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272568001266 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 272568001267 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 272568001268 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272568001269 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272568001270 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272568001271 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272568001272 NAD(P) binding site [chemical binding]; other site 272568001273 catalytic residues [active] 272568001274 acetylornithine deacetylase; Provisional; Region: PRK07522 272568001275 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 272568001276 metal binding site [ion binding]; metal-binding site 272568001277 putative dimer interface [polypeptide binding]; other site 272568001278 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272568001279 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 272568001280 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272568001281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568001282 ABC-ATPase subunit interface; other site 272568001283 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272568001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568001285 dimer interface [polypeptide binding]; other site 272568001286 conserved gate region; other site 272568001287 ABC-ATPase subunit interface; other site 272568001288 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272568001289 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272568001290 Walker A/P-loop; other site 272568001291 ATP binding site [chemical binding]; other site 272568001292 Q-loop/lid; other site 272568001293 ABC transporter signature motif; other site 272568001294 Walker B; other site 272568001295 D-loop; other site 272568001296 H-loop/switch region; other site 272568001297 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272568001298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272568001299 Walker A/P-loop; other site 272568001300 ATP binding site [chemical binding]; other site 272568001301 Q-loop/lid; other site 272568001302 ABC transporter signature motif; other site 272568001303 Walker B; other site 272568001304 D-loop; other site 272568001305 H-loop/switch region; other site 272568001306 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272568001307 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 272568001308 putative heme binding pocket [chemical binding]; other site 272568001309 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 272568001310 Pirin-related protein [General function prediction only]; Region: COG1741 272568001311 Pirin; Region: Pirin; pfam02678 272568001312 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 272568001313 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 272568001314 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272568001315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272568001316 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 272568001317 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272568001318 DNA binding site [nucleotide binding] 272568001319 active site 272568001320 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 272568001321 CAAX protease self-immunity; Region: Abi; pfam02517 272568001322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272568001323 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 272568001324 active site 272568001325 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 272568001326 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272568001327 substrate binding [chemical binding]; other site 272568001328 active site 272568001329 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272568001330 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568001331 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568001332 catalytic residue [active] 272568001333 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 272568001334 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272568001335 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272568001336 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272568001337 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272568001338 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272568001339 Walker A motif; other site 272568001340 ATP binding site [chemical binding]; other site 272568001341 Walker B motif; other site 272568001342 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272568001343 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272568001344 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272568001345 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 272568001346 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272568001347 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 272568001348 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 272568001349 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272568001350 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 272568001351 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272568001352 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 272568001353 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 272568001354 catalytic residue [active] 272568001355 Uncharacterized conserved protein [Function unknown]; Region: COG3189 272568001356 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 272568001357 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 272568001358 heme-binding site [chemical binding]; other site 272568001359 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 272568001360 FAD binding pocket [chemical binding]; other site 272568001361 FAD binding motif [chemical binding]; other site 272568001362 phosphate binding motif [ion binding]; other site 272568001363 beta-alpha-beta structure motif; other site 272568001364 NAD binding pocket [chemical binding]; other site 272568001365 Heme binding pocket [chemical binding]; other site 272568001366 Transcriptional regulator; Region: Rrf2; cl17282 272568001367 Rrf2 family protein; Region: rrf2_super; TIGR00738 272568001368 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 272568001369 putative ADP-binding pocket [chemical binding]; other site 272568001370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568001371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568001372 sequence-specific DNA binding site [nucleotide binding]; other site 272568001373 salt bridge; other site 272568001374 Predicted transcriptional regulator [Transcription]; Region: COG2932 272568001375 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272568001376 Catalytic site [active] 272568001377 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 272568001378 Predicted integral membrane protein [Function unknown]; Region: COG5617 272568001379 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 272568001380 putative ADP-binding pocket [chemical binding]; other site 272568001381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568001382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568001383 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272568001384 FeS/SAM binding site; other site 272568001385 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272568001386 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272568001387 hypothetical protein; Validated; Region: PRK09039 272568001388 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272568001389 ligand binding site [chemical binding]; other site 272568001390 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 272568001391 ligand binding site [chemical binding]; other site 272568001392 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 272568001393 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272568001394 active site 272568001395 dimerization interface [polypeptide binding]; other site 272568001396 elongation factor P; Validated; Region: PRK00529 272568001397 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272568001398 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272568001399 RNA binding site [nucleotide binding]; other site 272568001400 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272568001401 RNA binding site [nucleotide binding]; other site 272568001402 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 272568001403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568001404 FeS/SAM binding site; other site 272568001405 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 272568001406 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 272568001407 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272568001408 motif 1; other site 272568001409 dimer interface [polypeptide binding]; other site 272568001410 active site 272568001411 motif 2; other site 272568001412 motif 3; other site 272568001413 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 272568001414 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272568001415 active site 272568001416 thiamine phosphate binding site [chemical binding]; other site 272568001417 pyrophosphate binding site [ion binding]; other site 272568001418 Cell division protein ZapA; Region: ZapA; pfam05164 272568001419 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 272568001420 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272568001421 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272568001422 putative active site [active] 272568001423 metal binding site [ion binding]; metal-binding site 272568001424 homodimer binding site [polypeptide binding]; other site 272568001425 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272568001426 AMP nucleosidase; Provisional; Region: PRK08292 272568001427 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 272568001428 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 272568001429 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 272568001430 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 272568001431 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272568001432 minor groove reading motif; other site 272568001433 helix-hairpin-helix signature motif; other site 272568001434 active site 272568001435 acyl-CoA esterase; Provisional; Region: PRK10673 272568001436 PGAP1-like protein; Region: PGAP1; pfam07819 272568001437 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 272568001438 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 272568001439 NAD(P) binding site [chemical binding]; other site 272568001440 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272568001441 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 272568001442 Cl- selectivity filter; other site 272568001443 Cl- binding residues [ion binding]; other site 272568001444 pore gating glutamate residue; other site 272568001445 dimer interface [polypeptide binding]; other site 272568001446 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272568001447 glutamine synthetase; Provisional; Region: glnA; PRK09469 272568001448 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272568001449 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272568001450 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 272568001451 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272568001452 hypothetical protein; Provisional; Region: PRK08912 272568001453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568001454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568001455 homodimer interface [polypeptide binding]; other site 272568001456 catalytic residue [active] 272568001457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568001458 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272568001459 NAD(P) binding site [chemical binding]; other site 272568001460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568001461 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272568001462 23S rRNA interface [nucleotide binding]; other site 272568001463 L3 interface [polypeptide binding]; other site 272568001464 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272568001465 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272568001466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568001467 putative substrate translocation pore; other site 272568001468 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272568001469 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272568001470 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272568001471 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 272568001472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568001473 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 272568001474 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 272568001475 Trp docking motif [polypeptide binding]; other site 272568001476 putative active site [active] 272568001477 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 272568001478 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 272568001479 Bacterial transcriptional regulator; Region: IclR; pfam01614 272568001480 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272568001481 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 272568001482 glycogen synthase; Provisional; Region: PRK14099 272568001483 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272568001484 ADP-binding pocket [chemical binding]; other site 272568001485 homodimer interface [polypeptide binding]; other site 272568001486 glycogen branching enzyme; Provisional; Region: PRK05402 272568001487 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 272568001488 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 272568001489 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 272568001490 active site 272568001491 catalytic site [active] 272568001492 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272568001493 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 272568001494 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 272568001495 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272568001496 active site 272568001497 catalytic site [active] 272568001498 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 272568001499 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 272568001500 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 272568001501 catalytic site [active] 272568001502 active site 272568001503 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 272568001504 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 272568001505 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 272568001506 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 272568001507 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272568001508 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 272568001509 active site 272568001510 catalytic site [active] 272568001511 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272568001512 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272568001513 [2Fe-2S] cluster binding site [ion binding]; other site 272568001514 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 272568001515 active sites [active] 272568001516 tetramer interface [polypeptide binding]; other site 272568001517 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 272568001518 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568001519 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568001520 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568001521 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568001522 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568001523 oxidoreductase; Provisional; Region: PRK06196 272568001524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568001525 NAD(P) binding site [chemical binding]; other site 272568001526 active site 272568001527 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 272568001528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568001529 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 272568001530 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 272568001531 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 272568001532 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272568001533 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272568001534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568001535 dimer interface [polypeptide binding]; other site 272568001536 conserved gate region; other site 272568001537 putative PBP binding loops; other site 272568001538 ABC-ATPase subunit interface; other site 272568001539 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272568001540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568001541 dimer interface [polypeptide binding]; other site 272568001542 conserved gate region; other site 272568001543 putative PBP binding loops; other site 272568001544 ABC-ATPase subunit interface; other site 272568001545 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 272568001546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568001547 Walker A/P-loop; other site 272568001548 ATP binding site [chemical binding]; other site 272568001549 Q-loop/lid; other site 272568001550 ABC transporter signature motif; other site 272568001551 Walker B; other site 272568001552 D-loop; other site 272568001553 H-loop/switch region; other site 272568001554 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272568001555 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272568001556 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272568001557 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568001558 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568001559 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272568001560 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272568001561 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568001562 NnrU protein; Region: NnrU; pfam07298 272568001563 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 272568001564 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 272568001565 quinolinate synthetase; Provisional; Region: PRK09375 272568001566 L-aspartate oxidase; Provisional; Region: PRK07512 272568001567 L-aspartate oxidase; Provisional; Region: PRK06175 272568001568 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272568001569 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 272568001570 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272568001571 dimerization interface [polypeptide binding]; other site 272568001572 active site 272568001573 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272568001574 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272568001575 active site 272568001576 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272568001577 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 272568001578 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272568001579 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272568001580 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272568001581 dimer interface [polypeptide binding]; other site 272568001582 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272568001583 catalytic triad [active] 272568001584 peroxidatic and resolving cysteines [active] 272568001585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568001586 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 272568001587 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 272568001588 dimerization interface [polypeptide binding]; other site 272568001589 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 272568001590 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272568001591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568001592 S-adenosylmethionine binding site [chemical binding]; other site 272568001593 CHAP domain; Region: CHAP; cl17642 272568001594 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 272568001595 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 272568001596 intersubunit interface [polypeptide binding]; other site 272568001597 active site 272568001598 Zn2+ binding site [ion binding]; other site 272568001599 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 272568001600 Cupin domain; Region: Cupin_2; pfam07883 272568001601 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 272568001602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272568001603 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272568001604 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272568001605 active site 272568001606 Riboflavin kinase; Region: Flavokinase; smart00904 272568001607 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272568001608 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272568001609 active site 272568001610 HIGH motif; other site 272568001611 nucleotide binding site [chemical binding]; other site 272568001612 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272568001613 active site 272568001614 KMSKS motif; other site 272568001615 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272568001616 tRNA binding surface [nucleotide binding]; other site 272568001617 anticodon binding site; other site 272568001618 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272568001619 lipoprotein signal peptidase; Provisional; Region: PRK14770 272568001620 lipoprotein signal peptidase; Provisional; Region: PRK14787 272568001621 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 272568001622 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 272568001623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568001624 ATP binding site [chemical binding]; other site 272568001625 Mg2+ binding site [ion binding]; other site 272568001626 G-X-G motif; other site 272568001627 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272568001628 ATP binding site [chemical binding]; other site 272568001629 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 272568001630 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 272568001631 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272568001632 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 272568001633 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272568001634 dimer interface [polypeptide binding]; other site 272568001635 FMN binding site [chemical binding]; other site 272568001636 Major royal jelly protein; Region: MRJP; pfam03022 272568001637 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 272568001638 hypothetical protein; Provisional; Region: PRK02399 272568001639 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 272568001640 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272568001641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568001642 DNA-binding site [nucleotide binding]; DNA binding site 272568001643 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272568001644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568001645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568001646 homodimer interface [polypeptide binding]; other site 272568001647 catalytic residue [active] 272568001648 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 272568001649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568001650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568001651 dimerization interface [polypeptide binding]; other site 272568001652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272568001653 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568001654 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568001655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568001656 binding surface 272568001657 TPR motif; other site 272568001658 TPR repeat; Region: TPR_11; pfam13414 272568001659 TPR repeat; Region: TPR_11; pfam13414 272568001660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568001661 binding surface 272568001662 TPR motif; other site 272568001663 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568001664 Lysine efflux permease [General function prediction only]; Region: COG1279 272568001665 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 272568001666 L-fucose transporter; Provisional; Region: PRK10133; cl17665 272568001667 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 272568001668 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 272568001669 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 272568001670 active site 272568001671 aspartate aminotransferase; Provisional; Region: PRK05764 272568001672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568001673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568001674 homodimer interface [polypeptide binding]; other site 272568001675 catalytic residue [active] 272568001676 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272568001677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568001678 putative substrate translocation pore; other site 272568001679 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 272568001680 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 272568001681 active site 272568001682 substrate-binding site [chemical binding]; other site 272568001683 metal-binding site [ion binding] 272568001684 ATP binding site [chemical binding]; other site 272568001685 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272568001686 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 272568001687 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 272568001688 active site 272568001689 catalytic residue [active] 272568001690 dimer interface [polypeptide binding]; other site 272568001691 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 272568001692 ThiC-associated domain; Region: ThiC-associated; pfam13667 272568001693 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 272568001694 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272568001695 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568001696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568001697 catalytic residue [active] 272568001698 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272568001699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568001700 putative Zn2+ binding site [ion binding]; other site 272568001701 putative DNA binding site [nucleotide binding]; other site 272568001702 dimerization interface [polypeptide binding]; other site 272568001703 AsnC family; Region: AsnC_trans_reg; pfam01037 272568001705 Winged helix-turn helix; Region: HTH_29; pfam13551 272568001706 Homeodomain-like domain; Region: HTH_32; pfam13565 272568001707 Winged helix-turn helix; Region: HTH_33; pfam13592 272568001708 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568001709 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568001710 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568001711 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568001712 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272568001713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568001714 putative DNA binding site [nucleotide binding]; other site 272568001715 putative Zn2+ binding site [ion binding]; other site 272568001716 AsnC family; Region: AsnC_trans_reg; pfam01037 272568001717 CsbD-like; Region: CsbD; pfam05532 272568001718 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 272568001719 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 272568001720 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272568001721 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 272568001722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568001723 putative substrate translocation pore; other site 272568001724 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 272568001725 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 272568001726 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 272568001727 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272568001728 active site 272568001729 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 272568001730 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 272568001731 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272568001732 Predicted permeases [General function prediction only]; Region: COG0795 272568001733 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272568001734 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 272568001735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568001736 potassium uptake protein; Region: kup; TIGR00794 272568001737 K+ potassium transporter; Region: K_trans; pfam02705 272568001738 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 272568001739 dimerization interface [polypeptide binding]; other site 272568001740 metal binding site [ion binding]; metal-binding site 272568001741 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 272568001742 arogenate dehydrogenase; Region: PLN02256 272568001743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272568001744 Coenzyme A binding pocket [chemical binding]; other site 272568001745 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272568001746 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568001747 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 272568001748 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272568001749 NAD(P) binding site [chemical binding]; other site 272568001750 catalytic residues [active] 272568001751 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272568001752 DNA-binding interface [nucleotide binding]; DNA binding site 272568001753 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272568001754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568001755 putative substrate translocation pore; other site 272568001756 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272568001757 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272568001758 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 272568001759 Iron permease FTR1 family; Region: FTR1; cl00475 272568001760 Fe2+ transport protein; Region: Iron_transport; cl01377 272568001761 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272568001762 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 272568001763 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 272568001764 manganese transport protein MntH; Reviewed; Region: PRK00701 272568001765 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272568001766 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 272568001767 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 272568001768 FMN binding site [chemical binding]; other site 272568001769 dimer interface [polypeptide binding]; other site 272568001770 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272568001771 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 272568001772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568001773 active site 272568001774 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568001775 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568001776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568001777 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 272568001778 putative dimerization interface [polypeptide binding]; other site 272568001779 Predicted membrane protein [Function unknown]; Region: COG2855 272568001780 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160 272568001781 active site 272568001782 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 272568001783 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 272568001784 PhnA protein; Region: PhnA; pfam03831 272568001785 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272568001786 catalytic core [active] 272568001787 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272568001788 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272568001789 Walker A/P-loop; other site 272568001790 ATP binding site [chemical binding]; other site 272568001791 Q-loop/lid; other site 272568001792 ABC transporter signature motif; other site 272568001793 Walker B; other site 272568001794 D-loop; other site 272568001795 H-loop/switch region; other site 272568001796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272568001797 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272568001798 putative PBP binding regions; other site 272568001799 ABC-ATPase subunit interface; other site 272568001800 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272568001801 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272568001802 intersubunit interface [polypeptide binding]; other site 272568001803 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 272568001804 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568001805 N-terminal plug; other site 272568001806 ligand-binding site [chemical binding]; other site 272568001807 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272568001808 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 272568001809 putative active site [active] 272568001810 putative metal binding site [ion binding]; other site 272568001811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568001812 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 272568001813 Response regulator receiver domain; Region: Response_reg; pfam00072 272568001814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568001815 active site 272568001816 phosphorylation site [posttranslational modification] 272568001817 intermolecular recognition site; other site 272568001818 dimerization interface [polypeptide binding]; other site 272568001819 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568001820 DNA binding site [nucleotide binding] 272568001821 Winged helix-turn helix; Region: HTH_29; pfam13551 272568001822 Winged helix-turn helix; Region: HTH_33; pfam13592 272568001823 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568001824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568001825 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272568001826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272568001827 dimerization interface [polypeptide binding]; other site 272568001828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568001829 dimer interface [polypeptide binding]; other site 272568001830 phosphorylation site [posttranslational modification] 272568001831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568001832 ATP binding site [chemical binding]; other site 272568001833 Mg2+ binding site [ion binding]; other site 272568001834 G-X-G motif; other site 272568001835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568001836 NAD(P) binding site [chemical binding]; other site 272568001837 active site 272568001838 DNA Polymerase Y-family; Region: PolY_like; cd03468 272568001839 active site 272568001840 DNA binding site [nucleotide binding] 272568001841 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272568001842 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 272568001843 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 272568001844 putative active site [active] 272568001845 putative PHP Thumb interface [polypeptide binding]; other site 272568001846 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272568001847 generic binding surface II; other site 272568001848 generic binding surface I; other site 272568001849 enoyl-CoA hydratase; Provisional; Region: PRK06144 272568001850 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272568001851 substrate binding site [chemical binding]; other site 272568001852 oxyanion hole (OAH) forming residues; other site 272568001853 trimer interface [polypeptide binding]; other site 272568001854 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 272568001855 CoA-transferase family III; Region: CoA_transf_3; pfam02515 272568001856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568001857 D-galactonate transporter; Region: 2A0114; TIGR00893 272568001858 putative substrate translocation pore; other site 272568001859 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272568001860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568001861 DNA-binding site [nucleotide binding]; DNA binding site 272568001862 FCD domain; Region: FCD; pfam07729 272568001863 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272568001864 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272568001865 trimer interface [polypeptide binding]; other site 272568001866 putative metal binding site [ion binding]; other site 272568001867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568001868 putative substrate translocation pore; other site 272568001869 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 272568001870 Paraquat-inducible protein A; Region: PqiA; pfam04403 272568001871 Paraquat-inducible protein A; Region: PqiA; pfam04403 272568001872 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 272568001873 mce related protein; Region: MCE; pfam02470 272568001874 mce related protein; Region: MCE; pfam02470 272568001875 mce related protein; Region: MCE; pfam02470 272568001876 Protein of unknown function (DUF330); Region: DUF330; pfam03886 272568001877 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272568001878 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272568001879 putative homodimer interface [polypeptide binding]; other site 272568001880 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272568001881 heterodimer interface [polypeptide binding]; other site 272568001882 homodimer interface [polypeptide binding]; other site 272568001883 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 272568001884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568001885 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272568001886 putative substrate translocation pore; other site 272568001887 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 272568001888 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 272568001889 NADP binding site [chemical binding]; other site 272568001890 homodimer interface [polypeptide binding]; other site 272568001891 active site 272568001892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272568001893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272568001894 DNA binding site [nucleotide binding] 272568001895 domain linker motif; other site 272568001896 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 272568001897 putative dimerization interface [polypeptide binding]; other site 272568001898 putative ligand binding site [chemical binding]; other site 272568001899 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 272568001900 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272568001901 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272568001902 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272568001903 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272568001904 beta subunit interaction interface [polypeptide binding]; other site 272568001905 Walker A motif; other site 272568001906 ATP binding site [chemical binding]; other site 272568001907 Walker B motif; other site 272568001908 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272568001909 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272568001910 core domain interface [polypeptide binding]; other site 272568001911 delta subunit interface [polypeptide binding]; other site 272568001912 epsilon subunit interface [polypeptide binding]; other site 272568001913 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272568001914 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272568001915 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272568001916 alpha subunit interaction interface [polypeptide binding]; other site 272568001917 Walker A motif; other site 272568001918 ATP binding site [chemical binding]; other site 272568001919 Walker B motif; other site 272568001920 inhibitor binding site; inhibition site 272568001921 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272568001922 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 272568001923 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272568001924 gamma subunit interface [polypeptide binding]; other site 272568001925 epsilon subunit interface [polypeptide binding]; other site 272568001926 LBP interface [polypeptide binding]; other site 272568001927 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 272568001928 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272568001929 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272568001930 catalytic site [active] 272568001931 putative active site [active] 272568001932 putative substrate binding site [chemical binding]; other site 272568001933 HRDC domain; Region: HRDC; pfam00570 272568001934 GcrA cell cycle regulator; Region: GcrA; cl11564 272568001935 GcrA cell cycle regulator; Region: GcrA; cl11564 272568001936 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 272568001937 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 272568001938 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272568001939 substrate binding site [chemical binding]; other site 272568001940 ATP binding site [chemical binding]; other site 272568001941 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272568001942 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272568001943 G1 box; other site 272568001944 putative GEF interaction site [polypeptide binding]; other site 272568001945 GTP/Mg2+ binding site [chemical binding]; other site 272568001946 Switch I region; other site 272568001947 G2 box; other site 272568001948 G3 box; other site 272568001949 Switch II region; other site 272568001950 G4 box; other site 272568001951 G5 box; other site 272568001952 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272568001953 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272568001954 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 272568001955 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272568001956 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 272568001957 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272568001958 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 272568001959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568001960 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272568001961 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 272568001962 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272568001963 active site 272568001964 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272568001965 dimer interface [polypeptide binding]; other site 272568001966 substrate binding site [chemical binding]; other site 272568001967 catalytic residues [active] 272568001968 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272568001969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568001970 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272568001971 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272568001972 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 272568001973 Substrate binding site; other site 272568001974 metal-binding site 272568001975 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 272568001976 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272568001977 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 272568001978 Family description; Region: UvrD_C_2; pfam13538 272568001979 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272568001980 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272568001981 catalytic residues [active] 272568001982 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 272568001983 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 272568001984 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272568001985 B12 binding site [chemical binding]; other site 272568001986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568001987 FeS/SAM binding site; other site 272568001988 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 272568001989 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 272568001990 ligand binding site; other site 272568001991 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 272568001993 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 272568001994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568001995 FeS/SAM binding site; other site 272568001996 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 272568001997 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272568001998 Domain of unknown function DUF21; Region: DUF21; pfam01595 272568001999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272568002000 Transporter associated domain; Region: CorC_HlyC; smart01091 272568002001 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568002002 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568002003 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568002004 catalytic residue [active] 272568002005 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272568002006 Fe-S cluster binding site [ion binding]; other site 272568002007 active site 272568002008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568002009 TPR motif; other site 272568002010 binding surface 272568002011 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 272568002012 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272568002013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568002014 NAD(P) binding site [chemical binding]; other site 272568002015 active site 272568002016 Predicted membrane protein [Function unknown]; Region: COG1238 272568002017 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272568002018 dimerization interface [polypeptide binding]; other site 272568002019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568002020 ATP binding site [chemical binding]; other site 272568002021 Mg2+ binding site [ion binding]; other site 272568002022 G-X-G motif; other site 272568002023 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568002024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568002025 active site 272568002026 phosphorylation site [posttranslational modification] 272568002027 intermolecular recognition site; other site 272568002028 dimerization interface [polypeptide binding]; other site 272568002029 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568002030 DNA binding site [nucleotide binding] 272568002031 PRC-barrel domain; Region: PRC; pfam05239 272568002032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568002033 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568002034 putative substrate translocation pore; other site 272568002035 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272568002036 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272568002037 dimer interface [polypeptide binding]; other site 272568002038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568002039 catalytic residue [active] 272568002040 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272568002041 active site residue [active] 272568002042 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030 272568002043 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568002044 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568002045 active site 272568002046 catalytic tetrad [active] 272568002047 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 272568002048 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 272568002049 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 272568002050 4Fe-4S binding domain; Region: Fer4; pfam00037 272568002051 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 272568002052 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272568002053 Cysteine-rich domain; Region: CCG; pfam02754 272568002054 Cysteine-rich domain; Region: CCG; pfam02754 272568002055 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 272568002056 FAD binding domain; Region: FAD_binding_4; pfam01565 272568002057 FAD binding domain; Region: FAD_binding_4; pfam01565 272568002058 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 272568002059 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 272568002060 Cysteine-rich domain; Region: CCG; pfam02754 272568002061 Cysteine-rich domain; Region: CCG; pfam02754 272568002062 chaperone protein DnaJ; Provisional; Region: PRK14299 272568002063 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272568002064 HSP70 interaction site [polypeptide binding]; other site 272568002065 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272568002066 substrate binding site [polypeptide binding]; other site 272568002067 dimer interface [polypeptide binding]; other site 272568002068 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272568002069 DNA binding residues [nucleotide binding] 272568002070 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 272568002071 DNA photolyase; Region: DNA_photolyase; pfam00875 272568002072 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568002073 Winged helix-turn helix; Region: HTH_29; pfam13551 272568002074 Homeodomain-like domain; Region: HTH_32; pfam13565 272568002075 Winged helix-turn helix; Region: HTH_33; pfam13592 272568002076 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 272568002078 Winged helix-turn helix; Region: HTH_29; pfam13551 272568002079 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568002080 Integrase core domain; Region: rve; pfam00665 272568002081 Integrase core domain; Region: rve_3; pfam13683 272568002082 Phosphotransferase enzyme family; Region: APH; pfam01636 272568002083 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 272568002084 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568002085 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568002086 Fusaric acid resistance protein family; Region: FUSC; pfam04632 272568002087 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 272568002088 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272568002089 active site 272568002090 metal binding site [ion binding]; metal-binding site 272568002091 DNA binding site [nucleotide binding] 272568002092 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272568002093 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272568002094 MPT binding site; other site 272568002095 trimer interface [polypeptide binding]; other site 272568002096 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272568002097 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 272568002098 conserved cys residue [active] 272568002099 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 272568002100 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 272568002101 catalytic residue [active] 272568002102 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 272568002103 catalytic residues [active] 272568002104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568002105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568002106 peroxiredoxin; Region: AhpC; TIGR03137 272568002107 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272568002108 dimer interface [polypeptide binding]; other site 272568002109 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272568002110 catalytic triad [active] 272568002111 peroxidatic and resolving cysteines [active] 272568002112 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 272568002113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568002114 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 272568002115 dimerization interface [polypeptide binding]; other site 272568002116 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272568002117 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272568002118 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 272568002119 GTP cyclohydrolase I; Provisional; Region: PLN03044 272568002120 active site 272568002121 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 272568002122 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272568002123 homodimer interface [polypeptide binding]; other site 272568002124 substrate-cofactor binding pocket; other site 272568002125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568002126 catalytic residue [active] 272568002127 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 272568002128 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568002129 active site 272568002130 Purine nucleoside permease (NUP); Region: NUP; pfam06516 272568002131 Protein of unknown function (DUF330); Region: DUF330; pfam03886 272568002132 mce related protein; Region: MCE; pfam02470 272568002133 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272568002134 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 272568002135 Walker A/P-loop; other site 272568002136 ATP binding site [chemical binding]; other site 272568002137 Q-loop/lid; other site 272568002138 ABC transporter signature motif; other site 272568002139 Walker B; other site 272568002140 D-loop; other site 272568002141 H-loop/switch region; other site 272568002142 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272568002143 Permease; Region: Permease; pfam02405 272568002144 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272568002145 Biofilm formation and stress response factor; Region: BsmA; pfam10014 272568002146 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272568002147 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272568002148 RDD family; Region: RDD; pfam06271 272568002149 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272568002150 heterotetramer interface [polypeptide binding]; other site 272568002151 active site pocket [active] 272568002152 cleavage site 272568002153 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272568002154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272568002155 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568002156 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568002157 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272568002158 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272568002159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 272568002160 nucleotide binding region [chemical binding]; other site 272568002161 ATP-binding site [chemical binding]; other site 272568002162 SEC-C motif; Region: SEC-C; pfam02810 272568002163 hypothetical protein; Validated; Region: PRK00110 272568002164 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272568002165 active site 272568002166 putative DNA-binding cleft [nucleotide binding]; other site 272568002167 dimer interface [polypeptide binding]; other site 272568002168 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272568002169 RuvA N terminal domain; Region: RuvA_N; pfam01330 272568002170 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272568002171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568002172 Walker A motif; other site 272568002173 ATP binding site [chemical binding]; other site 272568002174 Walker B motif; other site 272568002175 arginine finger; other site 272568002176 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272568002177 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272568002178 active site 272568002179 TolQ protein; Region: tolQ; TIGR02796 272568002180 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272568002181 TolR protein; Region: tolR; TIGR02801 272568002182 translocation protein TolB; Provisional; Region: tolB; PRK05137 272568002183 TolB amino-terminal domain; Region: TolB_N; pfam04052 272568002184 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272568002185 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272568002186 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272568002187 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272568002188 ligand binding site [chemical binding]; other site 272568002189 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 272568002190 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272568002191 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272568002192 Ligand Binding Site [chemical binding]; other site 272568002193 FtsH Extracellular; Region: FtsH_ext; pfam06480 272568002194 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272568002195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568002196 Walker A motif; other site 272568002197 ATP binding site [chemical binding]; other site 272568002198 Walker B motif; other site 272568002199 arginine finger; other site 272568002200 Peptidase family M41; Region: Peptidase_M41; pfam01434 272568002201 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272568002202 dihydropteroate synthase; Region: DHPS; TIGR01496 272568002203 substrate binding pocket [chemical binding]; other site 272568002204 dimer interface [polypeptide binding]; other site 272568002205 inhibitor binding site; inhibition site 272568002206 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 272568002207 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272568002208 active site 272568002209 substrate binding site [chemical binding]; other site 272568002210 metal binding site [ion binding]; metal-binding site 272568002211 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272568002212 dimer interface [polypeptide binding]; other site 272568002213 substrate binding site [chemical binding]; other site 272568002214 ATP binding site [chemical binding]; other site 272568002215 Response regulator receiver domain; Region: Response_reg; pfam00072 272568002216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568002217 active site 272568002218 phosphorylation site [posttranslational modification] 272568002219 intermolecular recognition site; other site 272568002220 dimerization interface [polypeptide binding]; other site 272568002221 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 272568002222 aldehyde dehydrogenase family 7 member; Region: PLN02315 272568002223 tetrameric interface [polypeptide binding]; other site 272568002224 NAD binding site [chemical binding]; other site 272568002225 catalytic residues [active] 272568002226 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 272568002227 nucleotide binding site [chemical binding]; other site 272568002228 putative NEF/HSP70 interaction site [polypeptide binding]; other site 272568002229 SBD interface [polypeptide binding]; other site 272568002230 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 272568002231 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272568002232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272568002233 Coenzyme A binding pocket [chemical binding]; other site 272568002234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272568002235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272568002236 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 272568002237 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 272568002238 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272568002239 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272568002240 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272568002241 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272568002242 Ferritin-like domain; Region: Ferritin; pfam00210 272568002243 dimerization interface [polypeptide binding]; other site 272568002244 DPS ferroxidase diiron center [ion binding]; other site 272568002245 ion pore; other site 272568002246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272568002247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568002248 putative substrate translocation pore; other site 272568002249 POT family; Region: PTR2; cl17359 272568002250 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272568002251 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272568002252 active site 272568002253 DNA polymerase IV; Validated; Region: PRK02406 272568002254 DNA binding site [nucleotide binding] 272568002255 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272568002256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568002257 active site 272568002258 phosphorylation site [posttranslational modification] 272568002259 intermolecular recognition site; other site 272568002260 dimerization interface [polypeptide binding]; other site 272568002261 PAS domain S-box; Region: sensory_box; TIGR00229 272568002262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568002263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568002264 metal binding site [ion binding]; metal-binding site 272568002265 active site 272568002266 I-site; other site 272568002267 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568002268 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272568002269 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272568002270 NAD binding site [chemical binding]; other site 272568002271 homodimer interface [polypeptide binding]; other site 272568002272 active site 272568002273 substrate binding site [chemical binding]; other site 272568002274 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 272568002275 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272568002276 Substrate binding site; other site 272568002277 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 272568002278 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272568002279 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272568002280 putative acyl-acceptor binding pocket; other site 272568002281 CHRD domain; Region: CHRD; pfam07452 272568002282 cobalamin synthase; Reviewed; Region: cobS; PRK00235 272568002283 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 272568002284 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272568002285 putative dimer interface [polypeptide binding]; other site 272568002286 active site pocket [active] 272568002287 putative cataytic base [active] 272568002288 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 272568002289 homotrimer interface [polypeptide binding]; other site 272568002290 Walker A motif; other site 272568002291 GTP binding site [chemical binding]; other site 272568002292 Walker B motif; other site 272568002293 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568002294 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568002295 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568002296 putative effector binding pocket; other site 272568002297 dimerization interface [polypeptide binding]; other site 272568002298 Pirin-related protein [General function prediction only]; Region: COG1741 272568002299 Pirin; Region: Pirin; pfam02678 272568002300 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272568002301 Class II fumarases; Region: Fumarase_classII; cd01362 272568002302 active site 272568002303 tetramer interface [polypeptide binding]; other site 272568002304 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 272568002305 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 272568002306 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272568002307 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568002308 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568002309 Cytochrome c; Region: Cytochrom_C; pfam00034 272568002310 Domain of unknown function (DUF336); Region: DUF336; pfam03928 272568002311 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 272568002312 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 272568002313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568002314 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272568002315 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568002316 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568002317 Cytochrome c; Region: Cytochrom_C; pfam00034 272568002318 Major royal jelly protein; Region: MRJP; pfam03022 272568002319 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 272568002320 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 272568002321 quinone interaction residues [chemical binding]; other site 272568002322 active site 272568002323 catalytic residues [active] 272568002324 FMN binding site [chemical binding]; other site 272568002325 substrate binding site [chemical binding]; other site 272568002326 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 272568002327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568002328 active site 272568002329 motif I; other site 272568002330 motif II; other site 272568002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568002332 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 272568002333 VacJ like lipoprotein; Region: VacJ; cl01073 272568002334 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272568002335 active site 272568002336 catalytic residues [active] 272568002337 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 272568002338 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 272568002339 MOSC domain; Region: MOSC; pfam03473 272568002340 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 272568002341 Stringent starvation protein B; Region: SspB; pfam04386 272568002342 fumarate hydratase; Provisional; Region: PRK15389 272568002343 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 272568002344 Fumarase C-terminus; Region: Fumerase_C; pfam05683 272568002345 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 272568002346 dimer interface [polypeptide binding]; other site 272568002347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568002348 metal binding site [ion binding]; metal-binding site 272568002349 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 272568002350 amphipathic channel; other site 272568002351 Asn-Pro-Ala signature motifs; other site 272568002352 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568002353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568002354 metal binding site [ion binding]; metal-binding site 272568002355 active site 272568002356 I-site; other site 272568002357 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272568002358 substrate binding site [chemical binding]; other site 272568002359 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 272568002360 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272568002361 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272568002362 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272568002363 epoxyqueuosine reductase; Region: TIGR00276 272568002364 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 272568002365 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 272568002366 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 272568002367 putative metal binding site [ion binding]; other site 272568002368 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272568002369 Domain of unknown function DUF59; Region: DUF59; pfam01883 272568002370 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 272568002371 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272568002372 Walker A motif; other site 272568002373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272568002374 OpgC protein; Region: OpgC_C; pfam10129 272568002375 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272568002376 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272568002377 active site 272568002378 catalytic triad [active] 272568002379 oxyanion hole [active] 272568002380 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272568002381 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272568002382 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272568002383 protein binding site [polypeptide binding]; other site 272568002384 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272568002385 protein binding site [polypeptide binding]; other site 272568002386 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272568002387 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272568002388 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272568002389 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272568002390 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 272568002391 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 272568002392 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 272568002393 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 272568002394 Ligand binding site; other site 272568002395 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 272568002396 DXD motif; other site 272568002397 Predicted transcriptional regulators [Transcription]; Region: COG1695 272568002398 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272568002399 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 272568002400 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 272568002401 FAD binding pocket [chemical binding]; other site 272568002402 FAD binding motif [chemical binding]; other site 272568002403 phosphate binding motif [ion binding]; other site 272568002404 NAD binding pocket [chemical binding]; other site 272568002405 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 272568002406 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 272568002407 putative deacylase active site [active] 272568002408 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272568002409 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272568002410 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272568002411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568002412 NAD(P) binding site [chemical binding]; other site 272568002413 active site 272568002414 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272568002415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272568002416 ATP binding site [chemical binding]; other site 272568002417 putative Mg++ binding site [ion binding]; other site 272568002418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568002419 nucleotide binding region [chemical binding]; other site 272568002420 ATP-binding site [chemical binding]; other site 272568002421 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 272568002422 RNA binding site [nucleotide binding]; other site 272568002423 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272568002424 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 272568002425 putative NAD(P) binding site [chemical binding]; other site 272568002426 putative substrate binding site [chemical binding]; other site 272568002427 catalytic Zn binding site [ion binding]; other site 272568002428 structural Zn binding site [ion binding]; other site 272568002429 isocitrate dehydrogenase; Validated; Region: PRK08299 272568002430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 272568002431 SnoaL-like domain; Region: SnoaL_2; pfam12680 272568002432 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272568002433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 272568002434 Protein of unknown function, DUF482; Region: DUF482; pfam04339 272568002435 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 272568002436 homotrimer interaction site [polypeptide binding]; other site 272568002437 putative active site [active] 272568002438 TSCPD domain; Region: TSCPD; pfam12637 272568002439 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 272568002440 mce related protein; Region: MCE; pfam02470 272568002441 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272568002442 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 272568002443 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 272568002444 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 272568002445 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 272568002446 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 272568002447 active site 272568002448 homotetramer interface [polypeptide binding]; other site 272568002449 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 272568002450 NAD synthetase; Reviewed; Region: nadE; PRK02628 272568002451 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 272568002452 multimer interface [polypeptide binding]; other site 272568002453 active site 272568002454 catalytic triad [active] 272568002455 protein interface 1 [polypeptide binding]; other site 272568002456 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272568002457 homodimer interface [polypeptide binding]; other site 272568002458 NAD binding pocket [chemical binding]; other site 272568002459 ATP binding pocket [chemical binding]; other site 272568002460 Mg binding site [ion binding]; other site 272568002461 active-site loop [active] 272568002462 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568002463 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568002464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272568002465 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272568002466 active site 272568002467 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568002468 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568002469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568002470 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 272568002471 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272568002472 IHF dimer interface [polypeptide binding]; other site 272568002473 IHF - DNA interface [nucleotide binding]; other site 272568002474 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272568002475 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 272568002476 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 272568002477 Membrane fusogenic activity; Region: BMFP; pfam04380 272568002478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568002479 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 272568002480 NAD(P) binding site [chemical binding]; other site 272568002481 active site 272568002482 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 272568002483 Uncharacterized conserved protein [Function unknown]; Region: COG1565 272568002484 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272568002485 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 272568002486 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272568002487 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272568002488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272568002489 active site 272568002490 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272568002491 catalytic core [active] 272568002492 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 272568002493 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272568002494 5S rRNA interface [nucleotide binding]; other site 272568002495 CTC domain interface [polypeptide binding]; other site 272568002496 L16 interface [polypeptide binding]; other site 272568002497 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272568002498 putative active site [active] 272568002499 catalytic residue [active] 272568002500 GTP-binding protein YchF; Reviewed; Region: PRK09601 272568002501 YchF GTPase; Region: YchF; cd01900 272568002502 G1 box; other site 272568002503 GTP/Mg2+ binding site [chemical binding]; other site 272568002504 Switch I region; other site 272568002505 G2 box; other site 272568002506 Switch II region; other site 272568002507 G3 box; other site 272568002508 G4 box; other site 272568002509 G5 box; other site 272568002510 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272568002511 similar to gamma-glutamyl phosphate reductase; contains a frameshift 272568002512 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272568002513 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272568002514 active site 272568002515 (T/H)XGH motif; other site 272568002516 Oligomerisation domain; Region: Oligomerisation; pfam02410 272568002517 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272568002518 CHAP domain; Region: CHAP; cl17642 272568002519 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 272568002520 homotrimer interaction site [polypeptide binding]; other site 272568002521 putative active site [active] 272568002523 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 272568002524 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 272568002525 XdhC Rossmann domain; Region: XdhC_C; pfam13478 272568002526 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272568002527 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 272568002528 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272568002529 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272568002530 nucleophile elbow; other site 272568002531 Patatin phospholipase; Region: DUF3734; pfam12536 272568002532 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272568002533 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272568002534 catalytic residues [active] 272568002535 catalytic nucleophile [active] 272568002536 Recombinase; Region: Recombinase; pfam07508 272568002537 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272568002538 ParB-like nuclease domain; Region: ParBc; pfam02195 272568002539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568002540 Integrase core domain; Region: rve_3; pfam13683 272568002542 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272568002543 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 272568002544 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272568002545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568002546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568002547 dimerization interface [polypeptide binding]; other site 272568002548 SIR2-like domain; Region: SIR2_2; pfam13289 272568002549 Domain of unknown function DUF87; Region: DUF87; pfam01935 272568002550 AAA-like domain; Region: AAA_10; pfam12846 272568002551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272568002552 active site 272568002553 ATP binding site [chemical binding]; other site 272568002554 substrate binding site [chemical binding]; other site 272568002555 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272568002556 substrate binding site [chemical binding]; other site 272568002557 activation loop (A-loop); other site 272568002558 activation loop (A-loop); other site 272568002559 Transposase; Region: HTH_Tnp_1; pfam01527 272568002560 putative transposase OrfB; Reviewed; Region: PHA02517 272568002561 HTH-like domain; Region: HTH_21; pfam13276 272568002562 Integrase core domain; Region: rve; pfam00665 272568002563 Integrase core domain; Region: rve_3; pfam13683 272568002564 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272568002565 AAA domain; Region: AAA_30; pfam13604 272568002566 Family description; Region: UvrD_C_2; pfam13538 272568002567 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272568002568 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272568002569 catalytic residues [active] 272568002570 catalytic nucleophile [active] 272568002571 Recombinase; Region: Recombinase; pfam07508 272568002572 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272568002573 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 272568002574 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 272568002575 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 272568002576 ADP-ribose binding site [chemical binding]; other site 272568002577 Uncharacterized conserved protein [Function unknown]; Region: COG3465 272568002578 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568002579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568002580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 272568002581 Homeodomain-like domain; Region: HTH_23; pfam13384 272568002582 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 272568002583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568002584 Integrase core domain; Region: rve; pfam00665 272568002585 transposase; Provisional; Region: PRK06526 272568002586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568002587 Walker A motif; other site 272568002588 ATP binding site [chemical binding]; other site 272568002589 Walker B motif; other site 272568002590 Winged helix-turn helix; Region: HTH_29; pfam13551 272568002591 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568002592 Integrase core domain; Region: rve; pfam00665 272568002593 Integrase core domain; Region: rve_3; pfam13683 272568002594 HTH-like domain; Region: HTH_21; pfam13276 272568002595 Integrase core domain; Region: rve; pfam00665 272568002596 Integrase core domain; Region: rve_3; pfam13683 272568002597 Transposase; Region: HTH_Tnp_1; pfam01527 272568002598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272568002599 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568002600 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568002601 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568002602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568002603 Winged helix-turn helix; Region: HTH_29; pfam13551 272568002604 Integrase core domain; Region: rve; pfam00665 272568002605 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568002606 putative DNA binding site [nucleotide binding]; other site 272568002607 putative Zn2+ binding site [ion binding]; other site 272568002608 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272568002609 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272568002610 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272568002611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568002612 Integrase core domain; Region: rve; pfam00665 272568002613 transposase/IS protein; Provisional; Region: PRK09183 272568002614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568002615 Walker A motif; other site 272568002616 ATP binding site [chemical binding]; other site 272568002617 Walker B motif; other site 272568002618 arginine finger; other site 272568002619 Predicted transcriptional regulators [Transcription]; Region: COG1733 272568002620 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272568002621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568002622 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568002623 putative substrate translocation pore; other site 272568002624 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272568002625 dimer interface [polypeptide binding]; other site 272568002626 FMN binding site [chemical binding]; other site 272568002627 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272568002628 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272568002629 Pirin-related protein [General function prediction only]; Region: COG1741 272568002630 Pirin; Region: Pirin; pfam02678 272568002631 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568002632 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272568002633 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568002634 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568002635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568002636 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272568002637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568002638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568002639 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 272568002640 putative substrate binding pocket [chemical binding]; other site 272568002641 putative dimerization interface [polypeptide binding]; other site 272568002642 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272568002643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568002644 DNA-binding site [nucleotide binding]; DNA binding site 272568002645 FCD domain; Region: FCD; pfam07729 272568002646 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568002647 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 272568002648 putative C-terminal domain interface [polypeptide binding]; other site 272568002649 putative GSH binding site (G-site) [chemical binding]; other site 272568002650 putative dimer interface [polypeptide binding]; other site 272568002651 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 272568002652 putative N-terminal domain interface [polypeptide binding]; other site 272568002653 putative dimer interface [polypeptide binding]; other site 272568002654 putative substrate binding pocket (H-site) [chemical binding]; other site 272568002655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568002656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568002657 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568002658 putative effector binding pocket; other site 272568002659 dimerization interface [polypeptide binding]; other site 272568002660 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272568002661 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272568002662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568002663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568002664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568002665 dimerization interface [polypeptide binding]; other site 272568002666 Winged helix-turn helix; Region: HTH_29; pfam13551 272568002667 Integrase core domain; Region: rve; pfam00665 272568002668 Integrase core domain; Region: rve_3; pfam13683 272568002669 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 272568002670 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272568002671 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272568002672 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 272568002673 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272568002674 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 272568002675 VirB7 interaction site; other site 272568002676 conjugal transfer protein TrbF; Provisional; Region: PRK13872 272568002677 conjugal transfer protein TrbL; Provisional; Region: PRK13875 272568002678 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 272568002679 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 272568002680 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 272568002681 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 272568002682 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 272568002683 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272568002684 Walker A motif; other site 272568002685 ATP binding site [chemical binding]; other site 272568002686 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 272568002687 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 272568002688 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 272568002689 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 272568002690 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 272568002691 ATP binding site [chemical binding]; other site 272568002692 Walker A motif; other site 272568002693 hexamer interface [polypeptide binding]; other site 272568002694 Walker B motif; other site 272568002695 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272568002696 IHF dimer interface [polypeptide binding]; other site 272568002697 IHF - DNA interface [nucleotide binding]; other site 272568002698 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 272568002699 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 272568002700 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272568002701 Walker A motif; other site 272568002702 ATP binding site [chemical binding]; other site 272568002703 Walker B motif; other site 272568002704 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 272568002705 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 272568002706 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 272568002707 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 272568002708 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 272568002710 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272568002711 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272568002712 DHH family; Region: DHH; pfam01368 272568002713 DHHA1 domain; Region: DHHA1; pfam02272 272568002714 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272568002715 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 272568002716 putative active site [active] 272568002717 homoserine dehydrogenase; Provisional; Region: PRK06349 272568002718 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272568002719 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272568002720 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 272568002721 aminotransferase; Validated; Region: PRK09148 272568002722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568002723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568002724 homodimer interface [polypeptide binding]; other site 272568002725 catalytic residue [active] 272568002726 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272568002727 Clp protease; Region: CLP_protease; pfam00574 272568002728 oligomer interface [polypeptide binding]; other site 272568002729 active site residues [active] 272568002730 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 272568002731 dinuclear metal binding motif [ion binding]; other site 272568002732 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 272568002733 putative transposase OrfB; Reviewed; Region: PHA02517 272568002734 HTH-like domain; Region: HTH_21; pfam13276 272568002735 Integrase core domain; Region: rve; pfam00665 272568002736 Integrase core domain; Region: rve_3; cl15866 272568002737 YfdX protein; Region: YfdX; pfam10938 272568002738 hypothetical protein; Provisional; Region: PRK10316 272568002739 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 272568002740 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 272568002741 Na binding site [ion binding]; other site 272568002742 putative substrate binding site [chemical binding]; other site 272568002743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272568002746 Transposase; Region: HTH_Tnp_1; pfam01527 272568002747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272568002749 Peptidase family M23; Region: Peptidase_M23; pfam01551 272568002750 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272568002751 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272568002752 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272568002753 Presynaptic Site I dimer interface [polypeptide binding]; other site 272568002754 catalytic residues [active] 272568002755 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272568002756 Synaptic Flat tetramer interface [polypeptide binding]; other site 272568002757 Synaptic Site I dimer interface [polypeptide binding]; other site 272568002758 DNA binding site [nucleotide binding] 272568002759 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 272568002760 DNA-binding interface [nucleotide binding]; DNA binding site 272568002761 Transposase; Region: HTH_Tnp_1; pfam01527 272568002762 HTH-like domain; Region: HTH_21; pfam13276 272568002763 Integrase core domain; Region: rve; pfam00665 272568002766 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 272568002767 putative transposase OrfB; Reviewed; Region: PHA02517 272568002768 Integrase core domain; Region: rve; pfam00665 272568002769 Integrase core domain; Region: rve_3; cl15866 272568002770 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272568002771 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272568002772 putative dimer interface [polypeptide binding]; other site 272568002773 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 272568002774 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272568002777 Winged helix-turn helix; Region: HTH_29; pfam13551 272568002778 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568002779 Homeodomain-like domain; Region: HTH_32; pfam13565 272568002780 Transposase; Region: HTH_Tnp_1; pfam01527 272568002781 HTH-like domain; Region: HTH_21; pfam13276 272568002782 Integrase core domain; Region: rve; pfam00665 272568002783 Integrase core domain; Region: rve_3; pfam13683 272568002784 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568002785 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272568002786 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568002787 catalytic residue [active] 272568002793 Winged helix-turn helix; Region: HTH_29; pfam13551 272568002794 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568002795 Integrase core domain; Region: rve; pfam00665 272568002796 Integrase core domain; Region: rve_3; pfam13683 272568002800 putative transposase OrfB; Reviewed; Region: PHA02517 272568002801 HTH-like domain; Region: HTH_21; pfam13276 272568002802 Integrase core domain; Region: rve; pfam00665 272568002803 Integrase core domain; Region: rve_3; cl15866 272568002804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272568002805 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568002806 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568002807 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568002808 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568002810 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 272568002811 VirB7 interaction site; other site 272568002812 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272568002813 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 272568002814 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568002815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568002816 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272568002817 dimerization interface [polypeptide binding]; other site 272568002818 substrate binding pocket [chemical binding]; other site 272568002819 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568002820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568002821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568002822 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272568002823 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568002824 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568002825 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272568002826 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272568002827 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 272568002828 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272568002829 dimer interface [polypeptide binding]; other site 272568002830 active site 272568002831 Predicted transcriptional regulators [Transcription]; Region: COG1733 272568002832 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272568002833 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272568002834 classical (c) SDRs; Region: SDR_c; cd05233 272568002835 NAD(P) binding site [chemical binding]; other site 272568002836 active site 272568002837 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272568002838 DNA binding residues [nucleotide binding] 272568002839 HTH-like domain; Region: HTH_21; pfam13276 272568002840 Integrase core domain; Region: rve; pfam00665 272568002841 Integrase core domain; Region: rve_3; pfam13683 272568002842 Transposase; Region: HTH_Tnp_1; pfam01527 272568002846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568002847 Predicted transcriptional regulators [Transcription]; Region: COG1733 272568002848 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272568002849 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 272568002850 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272568002851 NADP binding site [chemical binding]; other site 272568002855 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568002856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568002857 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272568002858 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568002859 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272568002860 Protein export membrane protein; Region: SecD_SecF; cl14618 272568002861 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 272568002862 Na binding site [ion binding]; other site 272568002863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568002864 short chain dehydrogenase; Provisional; Region: PRK07024 272568002865 NAD(P) binding site [chemical binding]; other site 272568002866 active site 272568002867 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272568002868 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272568002869 catalytic site [active] 272568002870 G-X2-G-X-G-K; other site 272568002871 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 272568002872 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 272568002873 putative ribose interaction site [chemical binding]; other site 272568002874 putative ADP binding site [chemical binding]; other site 272568002875 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 272568002876 active site 272568002877 HIGH motif; other site 272568002878 nucleotide binding site [chemical binding]; other site 272568002879 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 272568002880 dimerization interface [polypeptide binding]; other site 272568002881 putative active cleft [active] 272568002882 replicative DNA helicase; Provisional; Region: PRK09165 272568002883 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272568002884 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272568002885 Walker A motif; other site 272568002886 ATP binding site [chemical binding]; other site 272568002887 Walker B motif; other site 272568002888 DNA binding loops [nucleotide binding] 272568002889 Uncharacterized conserved protein [Function unknown]; Region: COG1739 272568002890 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272568002891 DNA repair protein RadA; Provisional; Region: PRK11823 272568002892 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272568002893 Walker A motif/ATP binding site; other site 272568002894 ATP binding site [chemical binding]; other site 272568002895 Walker B motif; other site 272568002896 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272568002897 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272568002898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568002899 Walker A/P-loop; other site 272568002900 ATP binding site [chemical binding]; other site 272568002901 Q-loop/lid; other site 272568002902 ABC transporter signature motif; other site 272568002903 Walker B; other site 272568002904 D-loop; other site 272568002905 H-loop/switch region; other site 272568002906 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272568002907 Permease; Region: Permease; pfam02405 272568002908 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 272568002909 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272568002910 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272568002911 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272568002912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568002913 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 272568002914 putative substrate translocation pore; other site 272568002915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568002916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568002917 WHG domain; Region: WHG; pfam13305 272568002918 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 272568002919 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 272568002920 putative molybdopterin cofactor binding site [chemical binding]; other site 272568002921 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 272568002922 putative molybdopterin cofactor binding site; other site 272568002923 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 272568002924 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 272568002925 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 272568002926 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272568002927 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272568002928 MMPL family; Region: MMPL; pfam03176 272568002929 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 272568002930 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272568002931 homopentamer interface [polypeptide binding]; other site 272568002932 active site 272568002933 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272568002934 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 272568002935 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272568002936 dimerization interface [polypeptide binding]; other site 272568002937 active site 272568002938 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272568002939 Lumazine binding domain; Region: Lum_binding; pfam00677 272568002940 Lumazine binding domain; Region: Lum_binding; pfam00677 272568002941 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272568002942 catalytic motif [active] 272568002943 Zn binding site [ion binding]; other site 272568002944 RibD C-terminal domain; Region: RibD_C; cl17279 272568002945 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 272568002946 Na binding site [ion binding]; other site 272568002947 Beta-lactamase; Region: Beta-lactamase; pfam00144 272568002948 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272568002949 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272568002950 CoenzymeA binding site [chemical binding]; other site 272568002951 subunit interaction site [polypeptide binding]; other site 272568002952 PHB binding site; other site 272568002953 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272568002954 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 272568002955 active site 272568002956 catalytic residues [active] 272568002957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568002958 D-galactonate transporter; Region: 2A0114; TIGR00893 272568002959 putative substrate translocation pore; other site 272568002960 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272568002961 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568002962 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 272568002963 active site 272568002964 Zn binding site [ion binding]; other site 272568002965 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272568002966 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272568002967 active site 272568002968 metal binding site [ion binding]; metal-binding site 272568002969 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272568002970 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272568002971 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 272568002972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272568002973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272568002974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272568002975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568002976 PAS domain; Region: PAS_9; pfam13426 272568002977 putative active site [active] 272568002978 heme pocket [chemical binding]; other site 272568002979 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568002980 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568002981 metal binding site [ion binding]; metal-binding site 272568002982 active site 272568002983 I-site; other site 272568002984 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568002985 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 272568002986 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 272568002987 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 272568002988 putative active site [active] 272568002989 putative substrate binding site [chemical binding]; other site 272568002990 putative cosubstrate binding site; other site 272568002991 catalytic site [active] 272568002992 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 272568002993 NMT1/THI5 like; Region: NMT1; pfam09084 272568002994 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272568002995 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272568002996 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272568002997 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272568002998 Ligand binding site; other site 272568002999 Putative Catalytic site; other site 272568003000 DXD motif; other site 272568003001 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 272568003002 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 272568003003 ATP synthase subunit C; Region: ATP-synt_C; cl00466 272568003004 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272568003005 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 272568003006 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272568003007 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272568003008 purine monophosphate binding site [chemical binding]; other site 272568003009 dimer interface [polypeptide binding]; other site 272568003010 putative catalytic residues [active] 272568003011 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272568003012 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272568003013 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272568003014 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 272568003015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568003016 catalytic residue [active] 272568003017 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 272568003018 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272568003019 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272568003020 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272568003021 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272568003022 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272568003023 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272568003024 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272568003025 dimerization domain swap beta strand [polypeptide binding]; other site 272568003026 regulatory protein interface [polypeptide binding]; other site 272568003027 active site 272568003028 regulatory phosphorylation site [posttranslational modification]; other site 272568003029 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272568003030 active pocket/dimerization site; other site 272568003031 active site 272568003032 phosphorylation site [posttranslational modification] 272568003033 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 272568003034 shikimate kinase; Reviewed; Region: aroK; PRK00131 272568003035 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272568003036 Hpr binding site; other site 272568003037 active site 272568003038 homohexamer subunit interaction site [polypeptide binding]; other site 272568003039 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 272568003040 homotrimer interaction site [polypeptide binding]; other site 272568003041 putative active site [active] 272568003042 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272568003043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568003044 Walker A/P-loop; other site 272568003045 ATP binding site [chemical binding]; other site 272568003046 Q-loop/lid; other site 272568003047 ABC transporter signature motif; other site 272568003048 Walker B; other site 272568003049 D-loop; other site 272568003050 H-loop/switch region; other site 272568003051 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272568003052 Histidine kinase; Region: HisKA_3; pfam07730 272568003053 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 272568003054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272568003055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568003056 active site 272568003057 phosphorylation site [posttranslational modification] 272568003058 intermolecular recognition site; other site 272568003059 dimerization interface [polypeptide binding]; other site 272568003060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272568003061 DNA binding residues [nucleotide binding] 272568003062 dimerization interface [polypeptide binding]; other site 272568003063 hypothetical protein; Provisional; Region: PRK02853 272568003064 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272568003065 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 272568003066 putative ligand binding site [chemical binding]; other site 272568003067 NAD binding site [chemical binding]; other site 272568003068 catalytic site [active] 272568003069 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 272568003070 metabolite-proton symporter; Region: 2A0106; TIGR00883 272568003071 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272568003072 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272568003073 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272568003074 hypothetical protein; Provisional; Region: PRK02487 272568003075 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 272568003076 putative NAD(P) binding site [chemical binding]; other site 272568003077 catalytic Zn binding site [ion binding]; other site 272568003078 Protein of unknown function (DUF2501); Region: DUF2501; pfam10696 272568003079 YGGT family; Region: YGGT; pfam02325 272568003080 hypothetical protein; Provisional; Region: PRK09272 272568003081 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 272568003082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 272568003083 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 272568003084 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 272568003085 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272568003086 active site 272568003087 catalytic residues [active] 272568003088 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 272568003089 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272568003090 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 272568003091 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272568003092 substrate binding site [chemical binding]; other site 272568003093 active site 272568003094 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 272568003095 Maf-like protein; Provisional; Region: PRK14361 272568003096 putative active site [active] 272568003097 FtsX-like permease family; Region: FtsX; pfam02687 272568003098 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 272568003099 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272568003100 Walker A/P-loop; other site 272568003101 ATP binding site [chemical binding]; other site 272568003102 Q-loop/lid; other site 272568003103 ABC transporter signature motif; other site 272568003104 Walker B; other site 272568003105 D-loop; other site 272568003106 H-loop/switch region; other site 272568003107 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 272568003108 active site 272568003109 catalytic triad [active] 272568003110 oxyanion hole [active] 272568003111 switch loop; other site 272568003112 Predicted membrane protein [Function unknown]; Region: COG2259 272568003113 Winged helix-turn helix; Region: HTH_29; pfam13551 272568003114 Integrase core domain; Region: rve; pfam00665 272568003115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568003116 Integrase core domain; Region: rve_3; pfam13683 272568003117 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568003118 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568003119 N-terminal plug; other site 272568003120 ligand-binding site [chemical binding]; other site 272568003121 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272568003122 ParB-like nuclease domain; Region: ParB; smart00470 272568003123 KorB domain; Region: KorB; pfam08535 272568003124 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272568003125 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272568003126 P-loop; other site 272568003127 Magnesium ion binding site [ion binding]; other site 272568003128 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272568003129 Magnesium ion binding site [ion binding]; other site 272568003130 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272568003131 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 272568003132 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272568003133 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272568003134 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272568003135 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272568003136 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272568003137 G1 box; other site 272568003138 GTP/Mg2+ binding site [chemical binding]; other site 272568003139 Switch I region; other site 272568003140 G2 box; other site 272568003141 Switch II region; other site 272568003142 G3 box; other site 272568003143 G4 box; other site 272568003144 G5 box; other site 272568003145 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272568003146 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 272568003147 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272568003148 DNA binding site [nucleotide binding] 272568003149 active site 272568003150 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 272568003151 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 272568003152 NADP binding site [chemical binding]; other site 272568003153 dimer interface [polypeptide binding]; other site 272568003154 short chain dehydrogenase; Provisional; Region: PRK06197 272568003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568003156 NAD(P) binding site [chemical binding]; other site 272568003157 active site 272568003158 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272568003159 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272568003160 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 272568003161 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272568003162 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 272568003163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568003164 active site 272568003165 phosphorylation site [posttranslational modification] 272568003166 intermolecular recognition site; other site 272568003167 dimerization interface [polypeptide binding]; other site 272568003168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272568003169 DNA binding residues [nucleotide binding] 272568003170 dimerization interface [polypeptide binding]; other site 272568003171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568003172 dimer interface [polypeptide binding]; other site 272568003173 phosphorylation site [posttranslational modification] 272568003174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568003175 ATP binding site [chemical binding]; other site 272568003176 Mg2+ binding site [ion binding]; other site 272568003177 G-X-G motif; other site 272568003178 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 272568003179 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568003180 N-terminal plug; other site 272568003181 ligand-binding site [chemical binding]; other site 272568003182 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 272568003183 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272568003184 Sel1-like repeats; Region: SEL1; smart00671 272568003185 Sel1-like repeats; Region: SEL1; smart00671 272568003186 Sel1-like repeats; Region: SEL1; smart00671 272568003187 beta-ketothiolase; Provisional; Region: PRK09051 272568003188 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272568003189 dimer interface [polypeptide binding]; other site 272568003190 active site 272568003191 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272568003192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568003193 putative substrate translocation pore; other site 272568003194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568003195 hypothetical protein; Validated; Region: PRK00029 272568003196 Uncharacterized conserved protein [Function unknown]; Region: COG0397 272568003197 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 272568003198 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272568003199 substrate binding site [chemical binding]; other site 272568003200 oxyanion hole (OAH) forming residues; other site 272568003201 trimer interface [polypeptide binding]; other site 272568003202 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 272568003203 Flavin Reductases; Region: FlaRed; cl00801 272568003204 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272568003205 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272568003206 ABC-ATPase subunit interface; other site 272568003207 dimer interface [polypeptide binding]; other site 272568003208 putative PBP binding regions; other site 272568003209 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272568003210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568003211 Walker A/P-loop; other site 272568003212 ATP binding site [chemical binding]; other site 272568003213 Q-loop/lid; other site 272568003214 ABC transporter signature motif; other site 272568003215 Walker B; other site 272568003216 D-loop; other site 272568003217 H-loop/switch region; other site 272568003218 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272568003219 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 272568003220 intersubunit interface [polypeptide binding]; other site 272568003221 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272568003222 metal binding site 2 [ion binding]; metal-binding site 272568003223 putative DNA binding helix; other site 272568003224 metal binding site 1 [ion binding]; metal-binding site 272568003225 dimer interface [polypeptide binding]; other site 272568003226 structural Zn2+ binding site [ion binding]; other site 272568003227 L-asparaginase II; Region: Asparaginase_II; pfam06089 272568003228 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 272568003229 active site 272568003230 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272568003231 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272568003232 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272568003233 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272568003234 substrate binding site [chemical binding]; other site 272568003235 active site 272568003236 catalytic residues [active] 272568003237 heterodimer interface [polypeptide binding]; other site 272568003238 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 272568003239 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272568003240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568003241 catalytic residue [active] 272568003242 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 272568003243 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272568003244 Cl binding site [ion binding]; other site 272568003245 oligomer interface [polypeptide binding]; other site 272568003246 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272568003247 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 272568003248 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272568003249 RNA binding site [nucleotide binding]; other site 272568003250 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272568003251 multimer interface [polypeptide binding]; other site 272568003252 Walker A motif; other site 272568003253 ATP binding site [chemical binding]; other site 272568003254 Walker B motif; other site 272568003255 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 272568003256 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272568003257 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272568003258 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272568003259 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272568003260 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272568003261 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272568003262 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272568003263 chaperone protein DnaJ; Provisional; Region: PRK10767 272568003264 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272568003265 HSP70 interaction site [polypeptide binding]; other site 272568003266 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272568003267 Zn binding sites [ion binding]; other site 272568003268 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272568003269 dimer interface [polypeptide binding]; other site 272568003270 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272568003271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272568003272 nucleotide binding site [chemical binding]; other site 272568003273 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 272568003274 heat shock protein GrpE; Provisional; Region: PRK14141 272568003275 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272568003276 dimer interface [polypeptide binding]; other site 272568003277 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272568003278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568003279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568003280 active site 272568003281 phosphorylation site [posttranslational modification] 272568003282 intermolecular recognition site; other site 272568003283 dimerization interface [polypeptide binding]; other site 272568003284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568003285 DNA binding site [nucleotide binding] 272568003286 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 272568003287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272568003288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272568003289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568003290 dimer interface [polypeptide binding]; other site 272568003291 phosphorylation site [posttranslational modification] 272568003292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568003293 ATP binding site [chemical binding]; other site 272568003294 Mg2+ binding site [ion binding]; other site 272568003295 G-X-G motif; other site 272568003296 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272568003297 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568003298 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 272568003299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568003300 FeS/SAM binding site; other site 272568003301 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272568003302 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 272568003303 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 272568003304 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 272568003305 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 272568003306 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 272568003307 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272568003308 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272568003309 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272568003310 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272568003311 ligand binding site [chemical binding]; other site 272568003312 flexible hinge region; other site 272568003313 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272568003314 putative switch regulator; other site 272568003315 non-specific DNA interactions [nucleotide binding]; other site 272568003316 DNA binding site [nucleotide binding] 272568003317 sequence specific DNA binding site [nucleotide binding]; other site 272568003318 putative cAMP binding site [chemical binding]; other site 272568003319 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 272568003320 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 272568003321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 272568003322 FeS/SAM binding site; other site 272568003323 HemN C-terminal domain; Region: HemN_C; pfam06969 272568003324 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 272568003325 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 272568003326 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272568003327 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 272568003328 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272568003329 Ligand binding site [chemical binding]; other site 272568003330 Electron transfer flavoprotein domain; Region: ETF; pfam01012 272568003331 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272568003332 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 272568003333 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272568003334 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272568003335 putative efflux protein, MATE family; Region: matE; TIGR00797 272568003336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568003337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568003338 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 272568003339 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568003340 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272568003341 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568003342 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 272568003343 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272568003344 NAD binding site [chemical binding]; other site 272568003345 catalytic residues [active] 272568003346 substrate binding site [chemical binding]; other site 272568003347 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 272568003348 pyruvate kinase; Provisional; Region: PRK06247 272568003349 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272568003350 domain interfaces; other site 272568003351 active site 272568003352 Bacterial SH3 domain; Region: SH3_4; pfam06347 272568003353 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 272568003354 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272568003355 ATP binding site [chemical binding]; other site 272568003356 substrate interface [chemical binding]; other site 272568003357 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 272568003358 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 272568003359 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272568003360 active site 272568003361 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272568003362 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272568003363 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272568003364 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272568003365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272568003366 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272568003367 RNA binding surface [nucleotide binding]; other site 272568003368 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272568003369 pseudouridine synthase; Region: TIGR00093 272568003370 active site 272568003371 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 272568003372 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272568003373 catalytic triad [active] 272568003374 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272568003375 nucleoside/Zn binding site; other site 272568003376 dimer interface [polypeptide binding]; other site 272568003377 catalytic motif [active] 272568003378 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272568003379 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272568003380 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272568003381 protein binding site [polypeptide binding]; other site 272568003382 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272568003383 protein binding site [polypeptide binding]; other site 272568003384 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568003385 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 272568003386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568003387 catalytic residue [active] 272568003388 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 272568003389 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272568003390 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272568003391 homodimer interface [polypeptide binding]; other site 272568003392 NADP binding site [chemical binding]; other site 272568003393 substrate binding site [chemical binding]; other site 272568003394 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 272568003395 FAD binding site [chemical binding]; other site 272568003396 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 272568003397 Zn binding site [ion binding]; other site 272568003398 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272568003399 dimer interface [polypeptide binding]; other site 272568003400 ADP-ribose binding site [chemical binding]; other site 272568003401 active site 272568003402 nudix motif; other site 272568003403 metal binding site [ion binding]; metal-binding site 272568003404 major facilitator superfamily transporter; Provisional; Region: PRK05122 272568003405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568003406 putative substrate translocation pore; other site 272568003407 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 272568003408 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 272568003409 Winged helix-turn helix; Region: HTH_29; pfam13551 272568003410 Winged helix-turn helix; Region: HTH_33; pfam13592 272568003411 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568003412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568003413 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568003414 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568003415 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568003416 Protein of unknown function (DUF563); Region: DUF563; pfam04577 272568003417 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 272568003418 Na binding site [ion binding]; other site 272568003419 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 272568003420 pyruvate phosphate dikinase; Provisional; Region: PRK09279 272568003421 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272568003422 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272568003423 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272568003424 PEP synthetase regulatory protein; Provisional; Region: PRK05339 272568003425 ferrochelatase; Reviewed; Region: hemH; PRK00035 272568003426 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272568003427 C-terminal domain interface [polypeptide binding]; other site 272568003428 active site 272568003429 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272568003430 active site 272568003431 N-terminal domain interface [polypeptide binding]; other site 272568003432 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272568003433 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272568003434 minor groove reading motif; other site 272568003435 helix-hairpin-helix signature motif; other site 272568003436 substrate binding pocket [chemical binding]; other site 272568003437 active site 272568003438 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 272568003439 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272568003440 DNA binding and oxoG recognition site [nucleotide binding] 272568003441 Protein of unknown function (DUF721); Region: DUF721; pfam05258 272568003442 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272568003443 active site 272568003444 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272568003445 active site 272568003446 dimer interface [polypeptide binding]; other site 272568003447 hypothetical protein; Validated; Region: PRK09104 272568003448 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 272568003449 metal binding site [ion binding]; metal-binding site 272568003450 putative dimer interface [polypeptide binding]; other site 272568003451 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 272568003452 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 272568003453 active site 272568003454 hydrophilic channel; other site 272568003455 dimerization interface [polypeptide binding]; other site 272568003456 catalytic residues [active] 272568003457 active site lid [active] 272568003458 protease TldD; Provisional; Region: tldD; PRK10735 272568003459 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 272568003460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568003461 N-terminal plug; other site 272568003462 ligand-binding site [chemical binding]; other site 272568003463 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272568003464 Sel1-like repeats; Region: SEL1; smart00671 272568003465 Trehalase; Region: Trehalase; cl17346 272568003466 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 272568003467 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 272568003468 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272568003469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568003470 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 272568003471 putative substrate translocation pore; other site 272568003472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272568003473 active site 272568003474 Fusaric acid resistance protein family; Region: FUSC; pfam04632 272568003475 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272568003476 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272568003477 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272568003478 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272568003479 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272568003480 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272568003481 carboxyltransferase (CT) interaction site; other site 272568003482 biotinylation site [posttranslational modification]; other site 272568003483 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272568003484 Dehydroquinase class II; Region: DHquinase_II; pfam01220 272568003485 trimer interface [polypeptide binding]; other site 272568003486 active site 272568003487 dimer interface [polypeptide binding]; other site 272568003488 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272568003489 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272568003490 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 272568003491 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 272568003492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 272568003493 dimer interface [polypeptide binding]; other site 272568003494 active site 272568003495 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272568003496 catalytic residues [active] 272568003497 substrate binding site [chemical binding]; other site 272568003498 CcmB protein; Region: CcmB; cl17444 272568003499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568003500 ABC transporter; Region: ABC_tran; pfam00005 272568003501 Q-loop/lid; other site 272568003502 ABC transporter signature motif; other site 272568003503 Walker B; other site 272568003504 D-loop; other site 272568003505 H-loop/switch region; other site 272568003506 aconitate hydratase; Validated; Region: PRK09277 272568003507 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272568003508 substrate binding site [chemical binding]; other site 272568003509 ligand binding site [chemical binding]; other site 272568003510 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272568003511 substrate binding site [chemical binding]; other site 272568003512 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272568003513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568003514 Walker A/P-loop; other site 272568003515 ATP binding site [chemical binding]; other site 272568003516 Q-loop/lid; other site 272568003517 ABC transporter signature motif; other site 272568003518 Walker B; other site 272568003519 D-loop; other site 272568003520 H-loop/switch region; other site 272568003521 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272568003522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272568003523 substrate binding pocket [chemical binding]; other site 272568003524 membrane-bound complex binding site; other site 272568003525 hinge residues; other site 272568003526 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272568003527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568003528 dimer interface [polypeptide binding]; other site 272568003529 conserved gate region; other site 272568003530 putative PBP binding loops; other site 272568003531 ABC-ATPase subunit interface; other site 272568003532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568003533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568003534 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568003535 putative effector binding pocket; other site 272568003536 dimerization interface [polypeptide binding]; other site 272568003537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568003538 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272568003539 Walker A motif; other site 272568003540 ATP binding site [chemical binding]; other site 272568003541 Walker B motif; other site 272568003542 arginine finger; other site 272568003543 ribosome maturation protein RimP; Reviewed; Region: PRK00092 272568003544 Sm and related proteins; Region: Sm_like; cl00259 272568003545 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272568003546 putative oligomer interface [polypeptide binding]; other site 272568003547 putative RNA binding site [nucleotide binding]; other site 272568003548 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 272568003549 NusA N-terminal domain; Region: NusA_N; pfam08529 272568003550 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272568003551 RNA binding site [nucleotide binding]; other site 272568003552 homodimer interface [polypeptide binding]; other site 272568003553 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272568003554 G-X-X-G motif; other site 272568003555 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272568003556 G-X-X-G motif; other site 272568003557 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 272568003558 hypothetical protein; Provisional; Region: PRK09190 272568003559 Protein of unknown function (DUF448); Region: DUF448; pfam04296 272568003560 putative RNA binding cleft [nucleotide binding]; other site 272568003561 Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358 272568003562 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 272568003563 translation initiation factor IF-2; Region: IF-2; TIGR00487 272568003564 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272568003565 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272568003566 G1 box; other site 272568003567 putative GEF interaction site [polypeptide binding]; other site 272568003568 GTP/Mg2+ binding site [chemical binding]; other site 272568003569 Switch I region; other site 272568003570 G2 box; other site 272568003571 G3 box; other site 272568003572 Switch II region; other site 272568003573 G4 box; other site 272568003574 G5 box; other site 272568003575 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272568003576 Translation-initiation factor 2; Region: IF-2; pfam11987 272568003577 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272568003578 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272568003579 mce related protein; Region: MCE; pfam02470 272568003580 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 272568003581 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272568003582 RNA binding site [nucleotide binding]; other site 272568003583 active site 272568003584 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272568003585 16S/18S rRNA binding site [nucleotide binding]; other site 272568003586 S13e-L30e interaction site [polypeptide binding]; other site 272568003587 25S rRNA binding site [nucleotide binding]; other site 272568003588 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272568003589 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272568003590 RNase E interface [polypeptide binding]; other site 272568003591 trimer interface [polypeptide binding]; other site 272568003592 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272568003593 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272568003594 RNase E interface [polypeptide binding]; other site 272568003595 trimer interface [polypeptide binding]; other site 272568003596 active site 272568003597 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272568003598 putative nucleic acid binding region [nucleotide binding]; other site 272568003599 G-X-X-G motif; other site 272568003600 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272568003601 RNA binding site [nucleotide binding]; other site 272568003602 domain interface; other site 272568003603 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272568003604 FMN binding site [chemical binding]; other site 272568003605 substrate binding site [chemical binding]; other site 272568003606 putative catalytic residue [active] 272568003607 Cupin domain; Region: Cupin_2; pfam07883 272568003608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568003609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568003610 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568003611 putative effector binding pocket; other site 272568003612 dimerization interface [polypeptide binding]; other site 272568003613 Aspartyl protease; Region: Asp_protease_2; pfam13650 272568003614 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272568003615 protein binding site [polypeptide binding]; other site 272568003616 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272568003617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272568003618 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272568003619 active site 272568003620 dimerization interface [polypeptide binding]; other site 272568003621 ribonuclease PH; Reviewed; Region: rph; PRK00173 272568003622 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272568003623 hexamer interface [polypeptide binding]; other site 272568003624 active site 272568003625 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272568003626 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568003627 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568003628 active site 272568003629 catalytic tetrad [active] 272568003630 Transglycosylase; Region: Transgly; pfam00912 272568003631 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272568003632 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272568003633 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 272568003634 RF-1 domain; Region: RF-1; pfam00472 272568003635 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 272568003636 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 272568003637 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 272568003638 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272568003639 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272568003640 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 272568003641 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568003642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568003643 active site 272568003644 phosphorylation site [posttranslational modification] 272568003645 intermolecular recognition site; other site 272568003646 dimerization interface [polypeptide binding]; other site 272568003647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 272568003648 DNA binding site [nucleotide binding] 272568003649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272568003650 dimerization interface [polypeptide binding]; other site 272568003651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568003652 ATP binding site [chemical binding]; other site 272568003653 Mg2+ binding site [ion binding]; other site 272568003654 G-X-G motif; other site 272568003655 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 272568003656 active site 272568003657 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 272568003658 Trp docking motif [polypeptide binding]; other site 272568003659 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 272568003660 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 272568003661 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 272568003662 putative FMN binding site [chemical binding]; other site 272568003663 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272568003664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272568003665 Coenzyme A binding pocket [chemical binding]; other site 272568003666 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 272568003667 CPxP motif; other site 272568003668 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272568003669 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272568003670 metal binding site 2 [ion binding]; metal-binding site 272568003671 putative DNA binding helix; other site 272568003672 metal binding site 1 [ion binding]; metal-binding site 272568003673 dimer interface [polypeptide binding]; other site 272568003674 structural Zn2+ binding site [ion binding]; other site 272568003675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 272568003676 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 272568003677 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272568003678 putative active site [active] 272568003679 catalytic triad [active] 272568003680 putative dimer interface [polypeptide binding]; other site 272568003681 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272568003682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568003683 non-specific DNA binding site [nucleotide binding]; other site 272568003684 salt bridge; other site 272568003685 sequence-specific DNA binding site [nucleotide binding]; other site 272568003686 Putative phosphatase (DUF442); Region: DUF442; cl17385 272568003687 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 272568003688 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272568003689 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 272568003690 L-aspartate oxidase; Provisional; Region: PRK06175 272568003691 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272568003692 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 272568003693 putative SdhC subunit interface [polypeptide binding]; other site 272568003694 putative proximal heme binding site [chemical binding]; other site 272568003695 putative Iron-sulfur protein interface [polypeptide binding]; other site 272568003696 putative proximal quinone binding site; other site 272568003697 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 272568003698 Iron-sulfur protein interface; other site 272568003699 proximal quinone binding site [chemical binding]; other site 272568003700 SdhD (CybS) interface [polypeptide binding]; other site 272568003701 proximal heme binding site [chemical binding]; other site 272568003702 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272568003703 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272568003704 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 272568003705 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272568003706 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272568003707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568003708 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568003709 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272568003710 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 272568003711 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 272568003712 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272568003713 Predicted ATPase [General function prediction only]; Region: COG1485 272568003714 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 272568003715 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272568003716 TPP-binding site [chemical binding]; other site 272568003717 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272568003718 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 272568003719 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272568003720 E3 interaction surface; other site 272568003721 lipoyl attachment site [posttranslational modification]; other site 272568003722 e3 binding domain; Region: E3_binding; pfam02817 272568003723 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272568003724 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272568003725 E3 interaction surface; other site 272568003726 lipoyl attachment site [posttranslational modification]; other site 272568003727 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 272568003728 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272568003729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568003730 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272568003731 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272568003732 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272568003733 catalytic triad [active] 272568003734 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568003735 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568003736 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568003737 catalytic residue [active] 272568003738 Sporulation related domain; Region: SPOR; pfam05036 272568003739 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 272568003740 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 272568003741 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 272568003742 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272568003743 oligomer interface [polypeptide binding]; other site 272568003744 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272568003745 nucleoside/Zn binding site; other site 272568003746 dimer interface [polypeptide binding]; other site 272568003747 catalytic motif [active] 272568003748 xanthine permease; Region: pbuX; TIGR03173 272568003749 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 272568003750 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 272568003751 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 272568003752 homotetramer interface [polypeptide binding]; other site 272568003753 ligand binding site [chemical binding]; other site 272568003754 catalytic site [active] 272568003755 NAD binding site [chemical binding]; other site 272568003756 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 272568003757 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 272568003758 active site 272568003759 dimer interface [polypeptide binding]; other site 272568003760 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272568003761 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272568003762 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568003763 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568003764 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272568003765 RNA binding site [nucleotide binding]; other site 272568003766 Maf-like protein; Region: Maf; pfam02545 272568003767 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272568003768 active site 272568003769 dimer interface [polypeptide binding]; other site 272568003770 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272568003771 rRNA binding site [nucleotide binding]; other site 272568003772 predicted 30S ribosome binding site; other site 272568003773 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272568003774 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272568003775 NAD binding site [chemical binding]; other site 272568003776 dimerization interface [polypeptide binding]; other site 272568003777 product binding site; other site 272568003778 substrate binding site [chemical binding]; other site 272568003779 zinc binding site [ion binding]; other site 272568003780 catalytic residues [active] 272568003781 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 272568003782 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 272568003783 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272568003784 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272568003785 hinge; other site 272568003786 active site 272568003787 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272568003788 trimer interface [polypeptide binding]; other site 272568003789 active site 272568003790 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 272568003791 putative ADP-binding pocket [chemical binding]; other site 272568003792 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568003793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568003794 binding surface 272568003795 TPR motif; other site 272568003796 Tetratricopeptide repeat; Region: TPR_9; pfam13371 272568003797 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 272568003798 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 272568003799 putative active site [active] 272568003800 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272568003801 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272568003802 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272568003803 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272568003804 active site 272568003805 dimer interface [polypeptide binding]; other site 272568003806 motif 1; other site 272568003807 motif 2; other site 272568003808 motif 3; other site 272568003809 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272568003810 anticodon binding site; other site 272568003811 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272568003812 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272568003813 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272568003814 Predicted acetyltransferase [General function prediction only]; Region: COG3393 272568003815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272568003816 Coenzyme A binding pocket [chemical binding]; other site 272568003817 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 272568003818 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 272568003819 Protein of unknown function (DUF541); Region: SIMPL; cl01077 272568003820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272568003821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272568003822 dimerization interface [polypeptide binding]; other site 272568003823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568003824 dimer interface [polypeptide binding]; other site 272568003825 phosphorylation site [posttranslational modification] 272568003826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568003827 ATP binding site [chemical binding]; other site 272568003828 Mg2+ binding site [ion binding]; other site 272568003829 G-X-G motif; other site 272568003830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568003831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568003832 active site 272568003833 phosphorylation site [posttranslational modification] 272568003834 intermolecular recognition site; other site 272568003835 dimerization interface [polypeptide binding]; other site 272568003836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568003837 DNA binding site [nucleotide binding] 272568003838 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272568003839 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272568003840 protein binding site [polypeptide binding]; other site 272568003841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272568003842 ATP binding site [chemical binding]; other site 272568003843 putative Mg++ binding site [ion binding]; other site 272568003844 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 272568003845 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 272568003846 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272568003847 DsbD alpha interface [polypeptide binding]; other site 272568003848 catalytic residues [active] 272568003849 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272568003850 dimerization interface [polypeptide binding]; other site 272568003851 domain crossover interface; other site 272568003852 redox-dependent activation switch; other site 272568003853 ornithine carbamoyltransferase; Provisional; Region: PRK00779 272568003854 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272568003855 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272568003856 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 272568003857 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272568003858 inhibitor-cofactor binding pocket; inhibition site 272568003859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568003860 catalytic residue [active] 272568003861 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 272568003862 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272568003863 Peptidase family M1; Region: Peptidase_M1; pfam01433 272568003864 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 272568003865 Zn binding site [ion binding]; other site 272568003866 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 272568003867 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568003868 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568003869 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568003870 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568003871 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568003872 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272568003873 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 272568003874 putative ligand binding site [chemical binding]; other site 272568003875 NAD binding site [chemical binding]; other site 272568003876 dimerization interface [polypeptide binding]; other site 272568003877 catalytic site [active] 272568003878 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272568003879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568003880 Walker A/P-loop; other site 272568003881 ATP binding site [chemical binding]; other site 272568003882 Q-loop/lid; other site 272568003883 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568003884 ABC transporter signature motif; other site 272568003885 Walker B; other site 272568003886 D-loop; other site 272568003887 ABC transporter; Region: ABC_tran_2; pfam12848 272568003888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568003889 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 272568003890 EamA-like transporter family; Region: EamA; pfam00892 272568003891 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 272568003892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568003893 Mg2+ binding site [ion binding]; other site 272568003894 G-X-G motif; other site 272568003895 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272568003896 anchoring element; other site 272568003897 dimer interface [polypeptide binding]; other site 272568003898 ATP binding site [chemical binding]; other site 272568003899 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272568003900 active site 272568003901 putative metal-binding site [ion binding]; other site 272568003902 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272568003903 Transcriptional regulator; Region: Rrf2; pfam02082 272568003904 Predicted transcriptional regulator [Transcription]; Region: COG1959 272568003905 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272568003906 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272568003907 dimer interface [polypeptide binding]; other site 272568003908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568003909 catalytic residue [active] 272568003910 YceI-like domain; Region: YceI; pfam04264 272568003911 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 272568003912 Uncharacterized conserved protein [Function unknown]; Region: COG2353 272568003913 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 272568003914 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272568003915 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272568003916 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 272568003917 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272568003918 putative ligand binding site [chemical binding]; other site 272568003919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272568003920 nucleotide binding site [chemical binding]; other site 272568003921 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272568003922 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272568003923 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272568003924 Uncharacterized conserved protein [Function unknown]; Region: COG3347 272568003925 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 272568003926 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272568003927 nucleotide binding site [chemical binding]; other site 272568003928 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 272568003929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568003930 active site 272568003931 motif I; other site 272568003932 motif II; other site 272568003933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568003934 motif II; other site 272568003935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568003936 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568003937 TM-ABC transporter signature motif; other site 272568003938 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568003939 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568003940 TM-ABC transporter signature motif; other site 272568003941 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272568003942 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272568003943 Walker A/P-loop; other site 272568003944 ATP binding site [chemical binding]; other site 272568003945 Q-loop/lid; other site 272568003946 ABC transporter signature motif; other site 272568003947 Walker B; other site 272568003948 D-loop; other site 272568003949 H-loop/switch region; other site 272568003950 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272568003951 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 272568003952 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 272568003953 ligand binding site [chemical binding]; other site 272568003954 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 272568003955 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272568003956 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 272568003957 PAS domain; Region: PAS_9; pfam13426 272568003958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568003959 putative active site [active] 272568003960 heme pocket [chemical binding]; other site 272568003961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568003962 PAS domain; Region: PAS_9; pfam13426 272568003963 putative active site [active] 272568003964 heme pocket [chemical binding]; other site 272568003965 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272568003966 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568003967 dimer interface [polypeptide binding]; other site 272568003968 putative CheW interface [polypeptide binding]; other site 272568003969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568003970 binding surface 272568003971 TPR motif; other site 272568003972 TPR repeat; Region: TPR_11; pfam13414 272568003973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568003974 TPR motif; other site 272568003975 binding surface 272568003976 TPR repeat; Region: TPR_11; pfam13414 272568003977 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 272568003978 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568003979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568003980 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272568003981 dimerization interface [polypeptide binding]; other site 272568003982 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 272568003983 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272568003984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272568003985 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 272568003986 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 272568003987 homodimer interface [polypeptide binding]; other site 272568003988 active site 272568003989 FMN binding site [chemical binding]; other site 272568003990 substrate binding site [chemical binding]; other site 272568003991 4Fe-4S binding domain; Region: Fer4; cl02805 272568003992 4Fe-4S binding domain; Region: Fer4; pfam00037 272568003993 Protein required for attachment to host cells; Region: Host_attach; pfam10116 272568003994 FOG: CBS domain [General function prediction only]; Region: COG0517 272568003995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 272568003996 BON domain; Region: BON; pfam04972 272568003997 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 272568003998 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272568003999 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272568004000 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272568004001 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 272568004002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568004003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568004004 putative substrate translocation pore; other site 272568004005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272568004006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568004007 dimer interface [polypeptide binding]; other site 272568004008 phosphorylation site [posttranslational modification] 272568004009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568004010 ATP binding site [chemical binding]; other site 272568004011 Mg2+ binding site [ion binding]; other site 272568004012 G-X-G motif; other site 272568004013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568004014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004015 active site 272568004016 phosphorylation site [posttranslational modification] 272568004017 intermolecular recognition site; other site 272568004018 dimerization interface [polypeptide binding]; other site 272568004019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568004020 DNA binding site [nucleotide binding] 272568004021 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272568004022 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272568004023 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568004024 Outer membrane efflux protein; Region: OEP; pfam02321 272568004025 Outer membrane efflux protein; Region: OEP; pfam02321 272568004026 GTP-binding protein LepA; Provisional; Region: PRK05433 272568004027 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272568004028 G1 box; other site 272568004029 putative GEF interaction site [polypeptide binding]; other site 272568004030 GTP/Mg2+ binding site [chemical binding]; other site 272568004031 Switch I region; other site 272568004032 G2 box; other site 272568004033 G3 box; other site 272568004034 Switch II region; other site 272568004035 G4 box; other site 272568004036 G5 box; other site 272568004037 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272568004038 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272568004039 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272568004041 Tellurite resistance protein TerB; Region: TerB; cl17311 272568004042 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 272568004043 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272568004044 proposed catalytic triad [active] 272568004045 conserved cys residue [active] 272568004046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568004047 D-galactonate transporter; Region: 2A0114; TIGR00893 272568004048 putative substrate translocation pore; other site 272568004049 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272568004050 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272568004051 NAD(P) binding site [chemical binding]; other site 272568004052 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568004053 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568004054 TM-ABC transporter signature motif; other site 272568004055 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272568004056 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272568004057 NAD(P) binding site [chemical binding]; other site 272568004058 catalytic residues [active] 272568004059 choline dehydrogenase; Validated; Region: PRK02106 272568004060 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272568004061 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 272568004062 Coenzyme A transferase; Region: CoA_trans; smart00882 272568004063 Coenzyme A transferase; Region: CoA_trans; cl17247 272568004064 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272568004065 MULE transposase domain; Region: MULE; pfam10551 272568004069 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568004070 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004071 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568004073 Transposase domain (DUF772); Region: DUF772; pfam05598 272568004074 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004075 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568004076 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 272568004077 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 272568004078 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568004079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568004080 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272568004081 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 272568004082 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 272568004083 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568004084 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004085 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272568004086 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568004087 putative transposase OrfB; Reviewed; Region: PHA02517 272568004088 HTH-like domain; Region: HTH_21; pfam13276 272568004089 Integrase core domain; Region: rve; pfam00665 272568004090 Integrase core domain; Region: rve_3; pfam13683 272568004091 Transposase; Region: HTH_Tnp_1; pfam01527 272568004092 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568004093 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004094 Winged helix-turn helix; Region: HTH_29; pfam13551 272568004095 Homeodomain-like domain; Region: HTH_32; pfam13565 272568004096 Winged helix-turn helix; Region: HTH_33; pfam13592 272568004097 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568004098 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004099 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568004100 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568004101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568004102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272568004103 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568004104 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 272568004105 potassium uptake protein; Region: kup; TIGR00794 272568004106 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 272568004107 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272568004108 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272568004109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272568004110 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272568004111 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 272568004112 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 272568004113 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 272568004114 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 272568004115 Ligand Binding Site [chemical binding]; other site 272568004116 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272568004117 GAF domain; Region: GAF_3; pfam13492 272568004118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568004119 dimer interface [polypeptide binding]; other site 272568004120 phosphorylation site [posttranslational modification] 272568004121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568004122 ATP binding site [chemical binding]; other site 272568004123 Mg2+ binding site [ion binding]; other site 272568004124 G-X-G motif; other site 272568004125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568004126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004127 active site 272568004128 phosphorylation site [posttranslational modification] 272568004129 intermolecular recognition site; other site 272568004130 dimerization interface [polypeptide binding]; other site 272568004131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568004132 DNA binding site [nucleotide binding] 272568004134 Winged helix-turn helix; Region: HTH_29; pfam13551 272568004135 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568004136 Integrase core domain; Region: rve; pfam00665 272568004137 Integrase core domain; Region: rve_3; pfam13683 272568004138 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568004139 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004140 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568004143 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568004144 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004145 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568004147 Winged helix-turn helix; Region: HTH_29; pfam13551 272568004148 Integrase core domain; Region: rve; pfam00665 272568004149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568004150 Integrase core domain; Region: rve_3; pfam13683 272568004151 Part of AAA domain; Region: AAA_19; pfam13245 272568004152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568004153 Walker A motif; other site 272568004154 ATP binding site [chemical binding]; other site 272568004155 Walker B motif; other site 272568004156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568004157 Helix-turn-helix domain; Region: HTH_38; pfam13936 272568004158 Integrase core domain; Region: rve; pfam00665 272568004159 Winged helix-turn helix; Region: HTH_29; pfam13551 272568004160 Winged helix-turn helix; Region: HTH_33; pfam13592 272568004161 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568004162 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004163 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568004164 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272568004165 TrwC relaxase; Region: TrwC; pfam08751 272568004166 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 272568004167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568004168 Integrase core domain; Region: rve; pfam00665 272568004169 transposase/IS protein; Provisional; Region: PRK09183 272568004170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568004171 Walker A motif; other site 272568004172 ATP binding site [chemical binding]; other site 272568004173 Walker B motif; other site 272568004174 arginine finger; other site 272568004176 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568004177 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568004178 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568004179 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272568004180 active site 272568004181 Int/Topo IB signature motif; other site 272568004182 DNA binding site [nucleotide binding] 272568004183 Protein of unknown function DUF45; Region: DUF45; pfam01863 272568004184 hypothetical protein; Provisional; Region: PRK05170 272568004185 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272568004186 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272568004187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568004188 Walker A/P-loop; other site 272568004189 ATP binding site [chemical binding]; other site 272568004190 Q-loop/lid; other site 272568004191 ABC transporter signature motif; other site 272568004192 Walker B; other site 272568004193 D-loop; other site 272568004194 H-loop/switch region; other site 272568004195 TOBE domain; Region: TOBE_2; pfam08402 272568004196 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 272568004197 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 272568004198 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272568004199 MarR family; Region: MarR_2; pfam12802 272568004200 Fusaric acid resistance protein family; Region: FUSC; pfam04632 272568004201 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272568004202 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 272568004203 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272568004204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568004205 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568004206 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568004207 Protein of unknown function (DUF563); Region: DUF563; pfam04577 272568004208 Protein of unknown function (DUF563); Region: DUF563; pfam04577 272568004209 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 272568004210 Probable Catalytic site; other site 272568004211 metal-binding site 272568004212 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272568004213 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272568004214 Probable Catalytic site; other site 272568004215 metal-binding site 272568004216 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 272568004217 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272568004218 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 272568004219 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 272568004220 PA/protease or protease-like domain interface [polypeptide binding]; other site 272568004221 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 272568004222 metal binding site [ion binding]; metal-binding site 272568004223 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568004224 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272568004225 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568004226 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568004227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568004228 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568004229 putative substrate translocation pore; other site 272568004230 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272568004231 putative phosphoketolase; Provisional; Region: PRK05261 272568004232 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 272568004233 TPP-binding site; other site 272568004234 XFP C-terminal domain; Region: XFP_C; pfam09363 272568004235 Acetokinase family; Region: Acetate_kinase; cl17229 272568004236 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272568004237 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 272568004238 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 272568004239 Active site cavity [active] 272568004240 catalytic acid [active] 272568004241 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 272568004242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568004243 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 272568004244 active site lid residues [active] 272568004245 substrate binding pocket [chemical binding]; other site 272568004246 catalytic residues [active] 272568004247 substrate-Mg2+ binding site; other site 272568004248 aspartate-rich region 1; other site 272568004249 aspartate-rich region 2; other site 272568004250 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 272568004251 active site lid residues [active] 272568004252 substrate binding pocket [chemical binding]; other site 272568004253 catalytic residues [active] 272568004254 substrate-Mg2+ binding site; other site 272568004255 aspartate-rich region 1; other site 272568004256 aspartate-rich region 2; other site 272568004257 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 272568004258 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 272568004259 active site 272568004260 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 272568004261 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 272568004262 putative NADP binding site [chemical binding]; other site 272568004263 putative substrate binding site [chemical binding]; other site 272568004264 active site 272568004265 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 272568004266 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 272568004267 prephenate dehydrogenase; Validated; Region: PRK08507 272568004268 malate dehydrogenase; Provisional; Region: PRK13529 272568004269 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272568004270 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 272568004271 NAD(P) binding site [chemical binding]; other site 272568004272 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272568004273 catalytic core [active] 272568004274 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272568004275 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272568004276 substrate binding site; other site 272568004277 tetramer interface; other site 272568004278 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568004279 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568004280 N-terminal plug; other site 272568004281 ligand-binding site [chemical binding]; other site 272568004282 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 272568004284 Winged helix-turn helix; Region: HTH_29; pfam13551 272568004285 Homeodomain-like domain; Region: HTH_32; pfam13565 272568004286 Winged helix-turn helix; Region: HTH_33; pfam13592 272568004287 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568004288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568004289 LysR family transcriptional regulator; Provisional; Region: PRK14997 272568004290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568004291 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568004292 putative effector binding pocket; other site 272568004293 dimerization interface [polypeptide binding]; other site 272568004294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568004295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568004296 active site 272568004297 catalytic tetrad [active] 272568004298 Domain of unknown function (DUF336); Region: DUF336; cl01249 272568004299 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272568004300 Clp amino terminal domain; Region: Clp_N; pfam02861 272568004301 Clp amino terminal domain; Region: Clp_N; pfam02861 272568004302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568004303 Walker A motif; other site 272568004304 ATP binding site [chemical binding]; other site 272568004305 Walker B motif; other site 272568004306 arginine finger; other site 272568004307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568004308 Walker A motif; other site 272568004309 ATP binding site [chemical binding]; other site 272568004310 Walker B motif; other site 272568004311 arginine finger; other site 272568004312 Uncharacterized conserved protein [Function unknown]; Region: COG3334 272568004313 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 272568004314 FHIPEP family; Region: FHIPEP; pfam00771 272568004315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568004316 TPR motif; other site 272568004317 TPR repeat; Region: TPR_11; pfam13414 272568004318 binding surface 272568004319 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568004320 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272568004321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568004322 TPR motif; other site 272568004323 TPR repeat; Region: TPR_11; pfam13414 272568004324 binding surface 272568004325 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568004326 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568004327 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568004328 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 272568004329 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 272568004330 Rod binding protein; Region: Rod-binding; pfam10135 272568004331 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 272568004332 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 272568004333 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 272568004334 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 272568004335 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272568004336 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 272568004337 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272568004338 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272568004339 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 272568004340 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 272568004341 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 272568004342 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 272568004343 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 272568004344 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 272568004345 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272568004346 Cache domain; Region: Cache_1; pfam02743 272568004347 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272568004348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568004349 dimer interface [polypeptide binding]; other site 272568004350 putative CheW interface [polypeptide binding]; other site 272568004351 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 272568004352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004353 active site 272568004354 phosphorylation site [posttranslational modification] 272568004355 intermolecular recognition site; other site 272568004356 dimerization interface [polypeptide binding]; other site 272568004357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568004358 DNA binding site [nucleotide binding] 272568004359 Flagellar protein FlaF; Region: FlaF; cl11454 272568004360 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 272568004361 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 272568004362 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272568004363 Walker A motif; other site 272568004364 ATP binding site [chemical binding]; other site 272568004365 Walker B motif; other site 272568004366 flagellar motor protein MotB; Validated; Region: motB; PRK09041 272568004367 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272568004368 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272568004369 ligand binding site [chemical binding]; other site 272568004370 flagellar motor protein MotA; Validated; Region: PRK09110 272568004371 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 272568004372 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272568004373 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 272568004374 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 272568004375 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 272568004376 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272568004377 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 272568004378 FliG C-terminal domain; Region: FliG_C; pfam01706 272568004379 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 272568004380 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 272568004381 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 272568004382 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272568004383 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568004384 dimer interface [polypeptide binding]; other site 272568004385 putative CheW interface [polypeptide binding]; other site 272568004386 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366 272568004387 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272568004388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004389 active site 272568004390 phosphorylation site [posttranslational modification] 272568004391 intermolecular recognition site; other site 272568004392 dimerization interface [polypeptide binding]; other site 272568004393 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272568004394 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272568004395 putative binding surface; other site 272568004396 active site 272568004397 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272568004398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568004399 ATP binding site [chemical binding]; other site 272568004400 Mg2+ binding site [ion binding]; other site 272568004401 G-X-G motif; other site 272568004402 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 272568004403 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272568004404 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272568004405 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 272568004406 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272568004407 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 272568004408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004409 active site 272568004410 phosphorylation site [posttranslational modification] 272568004411 intermolecular recognition site; other site 272568004412 dimerization interface [polypeptide binding]; other site 272568004413 CheB methylesterase; Region: CheB_methylest; pfam01339 272568004414 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 272568004415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004416 active site 272568004417 phosphorylation site [posttranslational modification] 272568004418 intermolecular recognition site; other site 272568004419 dimerization interface [polypeptide binding]; other site 272568004420 CheD chemotactic sensory transduction; Region: CheD; cl00810 272568004421 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 272568004422 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 272568004423 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 272568004424 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272568004425 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 272568004426 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 272568004427 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272568004428 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272568004429 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 272568004430 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272568004431 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 272568004432 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 272568004433 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272568004434 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 272568004435 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272568004436 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 272568004437 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272568004438 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 272568004439 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 272568004440 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 272568004441 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 272568004442 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272568004443 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 272568004444 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 272568004445 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272568004446 Type IV pili component [Cell motility and secretion]; Region: COG5461 272568004447 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 272568004448 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 272568004449 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272568004450 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 272568004451 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 272568004452 ATP binding site [chemical binding]; other site 272568004453 Walker A motif; other site 272568004454 hexamer interface [polypeptide binding]; other site 272568004455 Walker B motif; other site 272568004456 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 272568004457 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272568004458 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 272568004459 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272568004460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568004461 TPR motif; other site 272568004462 TPR repeat; Region: TPR_11; pfam13414 272568004463 binding surface 272568004464 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 272568004465 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 272568004466 hypothetical protein; Provisional; Region: PRK07208 272568004467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272568004468 UDP-galactopyranose mutase; Region: GLF; pfam03275 272568004469 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 272568004470 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272568004471 active site 272568004472 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 272568004473 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272568004474 E3 interaction surface; other site 272568004475 lipoyl attachment site [posttranslational modification]; other site 272568004476 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272568004477 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272568004478 catalytic site [active] 272568004479 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272568004480 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272568004481 alpha subunit interface [polypeptide binding]; other site 272568004482 TPP binding site [chemical binding]; other site 272568004483 heterodimer interface [polypeptide binding]; other site 272568004484 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272568004485 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 272568004486 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272568004487 tetramer interface [polypeptide binding]; other site 272568004488 TPP-binding site [chemical binding]; other site 272568004489 heterodimer interface [polypeptide binding]; other site 272568004490 phosphorylation loop region [posttranslational modification] 272568004491 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 272568004492 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272568004493 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272568004494 ATP-grasp domain; Region: ATP-grasp; pfam02222 272568004495 AIR carboxylase; Region: AIRC; pfam00731 272568004496 Protein of unknown function (DUF465); Region: DUF465; pfam04325 272568004497 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 272568004498 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272568004499 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272568004500 putative dimer interface [polypeptide binding]; other site 272568004501 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 272568004502 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 272568004503 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272568004504 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 272568004505 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 272568004506 active site 272568004507 putative substrate binding pocket [chemical binding]; other site 272568004508 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272568004509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568004510 NAD(P) binding site [chemical binding]; other site 272568004511 active site 272568004512 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272568004513 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 272568004514 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272568004515 Protein export membrane protein; Region: SecD_SecF; pfam02355 272568004516 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272568004517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568004518 FeS/SAM binding site; other site 272568004519 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272568004520 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272568004521 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 272568004522 aromatic arch; other site 272568004523 DCoH dimer interaction site [polypeptide binding]; other site 272568004524 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 272568004525 DCoH tetramer interaction site [polypeptide binding]; other site 272568004526 substrate binding site [chemical binding]; other site 272568004527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568004528 ABC transporter ATPase component; Reviewed; Region: PRK11147 272568004529 ABC transporter; Region: ABC_tran_2; pfam12848 272568004530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568004531 two-component response regulator; Provisional; Region: PRK09191 272568004532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004533 active site 272568004534 phosphorylation site [posttranslational modification] 272568004535 intermolecular recognition site; other site 272568004536 dimerization interface [polypeptide binding]; other site 272568004537 Winged helix-turn helix; Region: HTH_29; pfam13551 272568004538 Integrase core domain; Region: rve; pfam00665 272568004539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568004540 Integrase core domain; Region: rve_3; pfam13683 272568004541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272568004542 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272568004543 RNA polymerase sigma factor; Provisional; Region: PRK12547 272568004544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272568004545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272568004546 DNA binding residues [nucleotide binding] 272568004547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272568004548 Histidine kinase; Region: HisKA_2; pfam07568 272568004549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568004550 ATP binding site [chemical binding]; other site 272568004551 Mg2+ binding site [ion binding]; other site 272568004552 G-X-G motif; other site 272568004553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568004554 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 272568004555 Walker A/P-loop; other site 272568004556 ATP binding site [chemical binding]; other site 272568004557 Q-loop/lid; other site 272568004558 ABC transporter signature motif; other site 272568004559 Walker B; other site 272568004560 D-loop; other site 272568004561 H-loop/switch region; other site 272568004562 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272568004563 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272568004564 Walker A/P-loop; other site 272568004565 ATP binding site [chemical binding]; other site 272568004566 Q-loop/lid; other site 272568004567 ABC transporter signature motif; other site 272568004568 Walker B; other site 272568004569 D-loop; other site 272568004570 H-loop/switch region; other site 272568004571 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 272568004572 ligand binding site [chemical binding]; other site 272568004573 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 272568004574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272568004575 ATP binding site [chemical binding]; other site 272568004576 putative Mg++ binding site [ion binding]; other site 272568004577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568004578 nucleotide binding region [chemical binding]; other site 272568004579 ATP-binding site [chemical binding]; other site 272568004580 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272568004581 HRDC domain; Region: HRDC; pfam00570 272568004582 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272568004583 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 272568004584 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272568004585 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 272568004586 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272568004587 amphipathic channel; other site 272568004588 Asn-Pro-Ala signature motifs; other site 272568004589 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 272568004590 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272568004591 N- and C-terminal domain interface [polypeptide binding]; other site 272568004592 active site 272568004593 MgATP binding site [chemical binding]; other site 272568004594 catalytic site [active] 272568004595 metal binding site [ion binding]; metal-binding site 272568004596 glycerol binding site [chemical binding]; other site 272568004597 homotetramer interface [polypeptide binding]; other site 272568004598 homodimer interface [polypeptide binding]; other site 272568004599 FBP binding site [chemical binding]; other site 272568004600 protein IIAGlc interface [polypeptide binding]; other site 272568004601 Protein of unknown function (DUF461); Region: DUF461; pfam04314 272568004602 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272568004603 ATP cone domain; Region: ATP-cone; pfam03477 272568004604 transcription antitermination factor NusB; Region: nusB; TIGR01951 272568004605 putative RNA binding site [nucleotide binding]; other site 272568004606 thiamine monophosphate kinase; Provisional; Region: PRK05731 272568004607 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 272568004608 ATP binding site [chemical binding]; other site 272568004609 dimerization interface [polypeptide binding]; other site 272568004610 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272568004611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568004612 NAD(P) binding site [chemical binding]; other site 272568004613 active site 272568004614 glucokinase, proteobacterial type; Region: glk; TIGR00749 272568004615 Glucokinase; Region: Glucokinase; pfam02685 272568004616 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 272568004617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272568004618 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272568004619 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272568004620 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272568004621 active site 272568004622 HIGH motif; other site 272568004623 nucleotide binding site [chemical binding]; other site 272568004624 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272568004625 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272568004626 active site 272568004627 KMSKS motif; other site 272568004628 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272568004629 tRNA binding surface [nucleotide binding]; other site 272568004630 anticodon binding site; other site 272568004631 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272568004632 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272568004633 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272568004634 Walker A/P-loop; other site 272568004635 ATP binding site [chemical binding]; other site 272568004636 ABC transporter; Region: ABC_tran; pfam00005 272568004637 Q-loop/lid; other site 272568004638 ABC transporter signature motif; other site 272568004639 Walker B; other site 272568004640 D-loop; other site 272568004641 H-loop/switch region; other site 272568004642 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 272568004643 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 272568004644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568004645 dimer interface [polypeptide binding]; other site 272568004646 conserved gate region; other site 272568004647 putative PBP binding loops; other site 272568004648 ABC-ATPase subunit interface; other site 272568004649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568004650 dimer interface [polypeptide binding]; other site 272568004651 conserved gate region; other site 272568004652 ABC-ATPase subunit interface; other site 272568004653 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272568004654 Flavoprotein; Region: Flavoprotein; pfam02441 272568004655 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 272568004656 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272568004657 trimer interface [polypeptide binding]; other site 272568004658 active site 272568004659 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272568004660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568004661 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272568004662 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272568004663 DNA binding site [nucleotide binding] 272568004664 catalytic residue [active] 272568004665 H2TH interface [polypeptide binding]; other site 272568004666 putative catalytic residues [active] 272568004667 turnover-facilitating residue; other site 272568004668 intercalation triad [nucleotide binding]; other site 272568004669 8OG recognition residue [nucleotide binding]; other site 272568004670 putative reading head residues; other site 272568004671 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272568004672 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272568004673 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 272568004674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568004675 Walker A motif; other site 272568004676 ATP binding site [chemical binding]; other site 272568004677 Walker B motif; other site 272568004678 arginine finger; other site 272568004679 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272568004680 DnaA box-binding interface [nucleotide binding]; other site 272568004681 DNA polymerase III subunit beta; Validated; Region: PRK05643 272568004682 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272568004683 putative DNA binding surface [nucleotide binding]; other site 272568004684 dimer interface [polypeptide binding]; other site 272568004685 beta-clamp/clamp loader binding surface; other site 272568004686 beta-clamp/translesion DNA polymerase binding surface; other site 272568004687 recombination protein F; Reviewed; Region: recF; PRK00064 272568004688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568004689 Walker A/P-loop; other site 272568004690 ATP binding site [chemical binding]; other site 272568004691 Q-loop/lid; other site 272568004692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568004693 ABC transporter signature motif; other site 272568004694 Walker B; other site 272568004695 D-loop; other site 272568004696 H-loop/switch region; other site 272568004697 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 272568004698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568004699 ATP binding site [chemical binding]; other site 272568004700 Mg2+ binding site [ion binding]; other site 272568004701 G-X-G motif; other site 272568004702 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272568004703 anchoring element; other site 272568004704 dimer interface [polypeptide binding]; other site 272568004705 ATP binding site [chemical binding]; other site 272568004706 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272568004707 active site 272568004708 putative metal-binding site [ion binding]; other site 272568004709 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272568004710 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 272568004711 phosphoglycolate phosphatase; Provisional; Region: PRK13222 272568004712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568004713 motif II; other site 272568004714 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 272568004715 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272568004716 Substrate binding site; other site 272568004717 Mg++ binding site; other site 272568004718 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272568004719 active site 272568004720 substrate binding site [chemical binding]; other site 272568004721 CoA binding site [chemical binding]; other site 272568004722 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272568004723 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272568004724 glutaminase active site [active] 272568004725 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272568004726 dimer interface [polypeptide binding]; other site 272568004727 active site 272568004728 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272568004729 dimer interface [polypeptide binding]; other site 272568004730 active site 272568004731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568004732 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 272568004733 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 272568004734 thiS-thiF/thiG interaction site; other site 272568004735 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 272568004736 ThiS interaction site; other site 272568004737 putative active site [active] 272568004738 tetramer interface [polypeptide binding]; other site 272568004739 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272568004740 thiamine phosphate binding site [chemical binding]; other site 272568004741 active site 272568004742 pyrophosphate binding site [ion binding]; other site 272568004743 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 272568004744 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272568004745 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272568004746 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272568004747 ligand binding site [chemical binding]; other site 272568004748 flexible hinge region; other site 272568004749 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 272568004750 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272568004751 catalytic loop [active] 272568004752 iron binding site [ion binding]; other site 272568004753 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272568004754 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272568004755 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272568004756 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272568004757 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272568004758 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272568004759 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568004760 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568004761 Cytochrome c; Region: Cytochrom_C; pfam00034 272568004762 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272568004763 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272568004764 amino acid transporter; Region: 2A0306; TIGR00909 272568004765 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 272568004766 active site 272568004767 oxyanion hole [active] 272568004768 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272568004769 mce related protein; Region: MCE; pfam02470 272568004770 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272568004771 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272568004772 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272568004773 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568004774 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568004775 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272568004776 Sporulation related domain; Region: SPOR; pfam05036 272568004777 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272568004778 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272568004779 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272568004780 thymidylate kinase; Validated; Region: tmk; PRK00698 272568004781 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272568004782 TMP-binding site; other site 272568004783 ATP-binding site [chemical binding]; other site 272568004784 DNA polymerase III subunit delta'; Validated; Region: PRK07471 272568004785 AAA ATPase domain; Region: AAA_16; pfam13191 272568004786 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272568004787 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 272568004788 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272568004789 active site 272568004790 HIGH motif; other site 272568004791 KMSKS motif; other site 272568004792 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272568004793 tRNA binding surface [nucleotide binding]; other site 272568004794 anticodon binding site; other site 272568004795 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272568004796 active site 272568004797 putative hydrolase; Provisional; Region: PRK02113 272568004798 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272568004799 PrkA family serine protein kinase; Provisional; Region: PRK15455 272568004800 AAA ATPase domain; Region: AAA_16; pfam13191 272568004801 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 272568004802 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272568004803 metal ion-dependent adhesion site (MIDAS); other site 272568004804 SpoVR family protein; Provisional; Region: PRK11767 272568004805 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 272568004806 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 272568004807 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 272568004808 Cytochrome c; Region: Cytochrom_C; pfam00034 272568004809 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 272568004810 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272568004811 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272568004812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272568004813 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272568004814 active site 272568004815 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 272568004816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568004817 S-adenosylmethionine binding site [chemical binding]; other site 272568004818 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272568004819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 272568004820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568004821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004822 active site 272568004823 phosphorylation site [posttranslational modification] 272568004824 intermolecular recognition site; other site 272568004825 dimerization interface [polypeptide binding]; other site 272568004826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568004827 DNA binding site [nucleotide binding] 272568004828 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272568004829 putative catalytic site [active] 272568004830 putative phosphate binding site [ion binding]; other site 272568004831 active site 272568004832 metal binding site A [ion binding]; metal-binding site 272568004833 DNA binding site [nucleotide binding] 272568004834 putative AP binding site [nucleotide binding]; other site 272568004835 putative metal binding site B [ion binding]; other site 272568004836 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272568004837 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272568004838 GIY-YIG motif/motif A; other site 272568004839 active site 272568004840 catalytic site [active] 272568004841 putative DNA binding site [nucleotide binding]; other site 272568004842 metal binding site [ion binding]; metal-binding site 272568004843 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272568004844 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272568004845 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 272568004846 MoaE interaction surface [polypeptide binding]; other site 272568004847 MoeB interaction surface [polypeptide binding]; other site 272568004848 thiocarboxylated glycine; other site 272568004849 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 272568004850 MoaE homodimer interface [polypeptide binding]; other site 272568004851 MoaD interaction [polypeptide binding]; other site 272568004852 active site residues [active] 272568004853 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 272568004854 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272568004855 active site 272568004856 dimer interface [polypeptide binding]; other site 272568004857 catalytic residues [active] 272568004858 effector binding site; other site 272568004859 R2 peptide binding site; other site 272568004860 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272568004861 dimer interface [polypeptide binding]; other site 272568004862 putative radical transfer pathway; other site 272568004863 diiron center [ion binding]; other site 272568004864 tyrosyl radical; other site 272568004865 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272568004866 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272568004867 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272568004868 substrate binding pocket [chemical binding]; other site 272568004869 chain length determination region; other site 272568004870 substrate-Mg2+ binding site; other site 272568004871 catalytic residues [active] 272568004872 aspartate-rich region 1; other site 272568004873 active site lid residues [active] 272568004874 aspartate-rich region 2; other site 272568004875 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272568004876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272568004877 active site 272568004878 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 272568004879 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272568004880 dimer interface [polypeptide binding]; other site 272568004881 active site 272568004882 citrylCoA binding site [chemical binding]; other site 272568004883 NADH binding [chemical binding]; other site 272568004884 cationic pore residues; other site 272568004885 oxalacetate/citrate binding site [chemical binding]; other site 272568004886 coenzyme A binding site [chemical binding]; other site 272568004887 catalytic triad [active] 272568004888 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272568004889 catalytic core [active] 272568004890 chorismate mutase; Provisional; Region: PRK09239 272568004891 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272568004892 active site 272568004893 metal binding site [ion binding]; metal-binding site 272568004894 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 272568004895 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 272568004896 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 272568004897 AAA domain; Region: AAA_23; pfam13476 272568004898 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272568004899 Walker A/P-loop; other site 272568004900 ATP binding site [chemical binding]; other site 272568004901 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272568004902 ABC transporter signature motif; other site 272568004903 Walker B; other site 272568004904 D-loop; other site 272568004905 H-loop/switch region; other site 272568004906 Thioredoxin; Region: Thioredoxin_4; pfam13462 272568004907 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272568004908 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 272568004909 Sodium Bile acid symporter family; Region: SBF; cl17470 272568004910 FOG: CBS domain [General function prediction only]; Region: COG0517 272568004911 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272568004912 Transporter associated domain; Region: CorC_HlyC; smart01091 272568004913 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 272568004914 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272568004915 PhoH-like protein; Region: PhoH; pfam02562 272568004916 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 272568004917 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272568004918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568004919 FeS/SAM binding site; other site 272568004920 TRAM domain; Region: TRAM; cl01282 272568004921 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272568004922 Surface antigen; Region: Bac_surface_Ag; pfam01103 272568004923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 272568004924 Family of unknown function (DUF490); Region: DUF490; pfam04357 272568004925 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272568004926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568004927 TPR motif; other site 272568004928 binding surface 272568004929 TPR repeat; Region: TPR_11; pfam13414 272568004930 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272568004931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568004932 active site 272568004933 phosphorylation site [posttranslational modification] 272568004934 intermolecular recognition site; other site 272568004935 dimerization interface [polypeptide binding]; other site 272568004936 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 272568004937 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 272568004938 Predicted membrane protein [Function unknown]; Region: COG4125 272568004939 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 272568004940 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 272568004941 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 272568004942 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 272568004943 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 272568004944 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 272568004945 substrate binding site [chemical binding]; other site 272568004946 catalytic Zn binding site [ion binding]; other site 272568004947 NAD binding site [chemical binding]; other site 272568004948 structural Zn binding site [ion binding]; other site 272568004949 dimer interface [polypeptide binding]; other site 272568004950 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 272568004951 S-formylglutathione hydrolase; Region: PLN02442 272568004952 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 272568004953 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272568004954 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272568004955 active site 272568004956 HIGH motif; other site 272568004957 dimer interface [polypeptide binding]; other site 272568004958 KMSKS motif; other site 272568004959 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272568004960 argininosuccinate synthase; Provisional; Region: PRK13820 272568004961 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272568004962 ANP binding site [chemical binding]; other site 272568004963 Substrate Binding Site II [chemical binding]; other site 272568004964 Substrate Binding Site I [chemical binding]; other site 272568004965 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 272568004966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568004967 FeS/SAM binding site; other site 272568004968 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272568004969 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272568004970 RNA binding surface [nucleotide binding]; other site 272568004971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568004972 S-adenosylmethionine binding site [chemical binding]; other site 272568004973 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 272568004974 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272568004975 TPP-binding site; other site 272568004976 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272568004977 PYR/PP interface [polypeptide binding]; other site 272568004978 dimer interface [polypeptide binding]; other site 272568004979 TPP binding site [chemical binding]; other site 272568004980 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272568004981 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272568004982 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272568004983 substrate binding pocket [chemical binding]; other site 272568004984 chain length determination region; other site 272568004985 substrate-Mg2+ binding site; other site 272568004986 catalytic residues [active] 272568004987 aspartate-rich region 1; other site 272568004988 active site lid residues [active] 272568004989 aspartate-rich region 2; other site 272568004990 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272568004991 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 272568004992 CPxP motif; other site 272568004993 fructokinase; Reviewed; Region: PRK09557 272568004994 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272568004995 nucleotide binding site [chemical binding]; other site 272568004996 Acetokinase family; Region: Acetate_kinase; cl17229 272568004997 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 272568004998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568004999 S-adenosylmethionine binding site [chemical binding]; other site 272568005000 exopolyphosphatase; Region: exo_poly_only; TIGR03706 272568005001 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 272568005002 MASE1; Region: MASE1; cl17823 272568005003 PAS fold; Region: PAS; pfam00989 272568005004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568005005 putative active site [active] 272568005006 heme pocket [chemical binding]; other site 272568005007 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568005008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568005009 metal binding site [ion binding]; metal-binding site 272568005010 active site 272568005011 I-site; other site 272568005012 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 272568005013 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 272568005014 ligand binding site [chemical binding]; other site 272568005015 NAD binding site [chemical binding]; other site 272568005016 tetramer interface [polypeptide binding]; other site 272568005017 catalytic site [active] 272568005018 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 272568005019 L-serine binding site [chemical binding]; other site 272568005020 ACT domain interface; other site 272568005021 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272568005022 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 272568005023 active site 272568005024 Cytochrome c; Region: Cytochrom_C; cl11414 272568005025 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272568005026 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 272568005027 active site 272568005028 prephenate dehydratase; Provisional; Region: PRK11899 272568005029 Prephenate dehydratase; Region: PDT; pfam00800 272568005030 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272568005031 putative L-Phe binding site [chemical binding]; other site 272568005032 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 272568005033 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272568005034 dimer interface [polypeptide binding]; other site 272568005035 active site 272568005036 catalytic residue [active] 272568005037 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272568005038 SmpB-tmRNA interface; other site 272568005039 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272568005040 DNA-binding site [nucleotide binding]; DNA binding site 272568005041 RNA-binding motif; other site 272568005042 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272568005043 DNA-binding site [nucleotide binding]; DNA binding site 272568005044 RNA-binding motif; other site 272568005045 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 272568005046 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272568005047 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272568005048 generic binding surface II; other site 272568005049 ssDNA binding site; other site 272568005050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272568005051 ATP binding site [chemical binding]; other site 272568005052 putative Mg++ binding site [ion binding]; other site 272568005053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568005054 nucleotide binding region [chemical binding]; other site 272568005055 ATP-binding site [chemical binding]; other site 272568005056 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 272568005057 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272568005058 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272568005059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272568005060 ATP binding site [chemical binding]; other site 272568005061 putative Mg++ binding site [ion binding]; other site 272568005062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568005063 nucleotide binding region [chemical binding]; other site 272568005064 ATP-binding site [chemical binding]; other site 272568005065 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272568005066 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272568005067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568005068 NAD(P) binding site [chemical binding]; other site 272568005069 active site 272568005070 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 272568005071 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 272568005072 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272568005073 tyrosine decarboxylase; Region: PLN02880 272568005074 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568005075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568005076 catalytic residue [active] 272568005077 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 272568005078 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 272568005079 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 272568005080 metal ion-dependent adhesion site (MIDAS); other site 272568005081 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 272568005082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272568005083 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272568005084 HSP70 interaction site [polypeptide binding]; other site 272568005085 BolA-like protein; Region: BolA; pfam01722 272568005086 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 272568005087 lipoate-protein ligase B; Provisional; Region: PRK14341 272568005088 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272568005089 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272568005090 active site 272568005091 tetramer interface; other site 272568005092 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 272568005093 active site 272568005094 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272568005095 substrate binding site [chemical binding]; other site 272568005096 metal binding site [ion binding]; metal-binding site 272568005097 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 272568005098 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 272568005099 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568005100 FeS/SAM binding site; other site 272568005101 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272568005102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568005103 S-adenosylmethionine binding site [chemical binding]; other site 272568005104 comF family protein; Region: comF; TIGR00201 272568005105 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272568005106 active site 272568005107 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 272568005108 GSH binding site [chemical binding]; other site 272568005109 catalytic residues [active] 272568005110 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 272568005111 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 272568005112 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 272568005113 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 272568005114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568005115 S-adenosylmethionine binding site [chemical binding]; other site 272568005116 aspartate kinase; Reviewed; Region: PRK06635 272568005117 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 272568005118 putative nucleotide binding site [chemical binding]; other site 272568005119 putative catalytic residues [active] 272568005120 putative Mg ion binding site [ion binding]; other site 272568005121 putative aspartate binding site [chemical binding]; other site 272568005122 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 272568005123 putative allosteric regulatory site; other site 272568005124 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 272568005125 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 272568005126 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272568005127 FMN binding site [chemical binding]; other site 272568005128 substrate binding site [chemical binding]; other site 272568005129 putative catalytic residue [active] 272568005130 Helix-turn-helix domain; Region: HTH_25; pfam13413 272568005131 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 272568005132 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272568005133 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272568005134 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272568005135 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272568005136 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272568005137 dimer interface [polypeptide binding]; other site 272568005138 motif 1; other site 272568005139 active site 272568005140 motif 2; other site 272568005141 motif 3; other site 272568005142 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272568005143 anticodon binding site; other site 272568005144 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272568005145 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272568005146 RF-1 domain; Region: RF-1; pfam00472 272568005147 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272568005148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568005149 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 272568005150 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272568005151 inhibitor-cofactor binding pocket; inhibition site 272568005152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568005153 catalytic residue [active] 272568005154 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 272568005155 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272568005156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568005157 catalytic residue [active] 272568005158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272568005159 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 272568005160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568005161 S-adenosylmethionine binding site [chemical binding]; other site 272568005162 AAA domain; Region: AAA_26; pfam13500 272568005163 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 272568005164 LexA repressor; Validated; Region: PRK00215 272568005165 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 272568005166 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272568005167 Catalytic site [active] 272568005168 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272568005169 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272568005170 dimer interface [polypeptide binding]; other site 272568005171 putative functional site; other site 272568005172 putative MPT binding site; other site 272568005173 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272568005174 Septum formation initiator; Region: DivIC; cl17659 272568005175 enolase; Provisional; Region: eno; PRK00077 272568005176 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272568005177 dimer interface [polypeptide binding]; other site 272568005178 metal binding site [ion binding]; metal-binding site 272568005179 substrate binding pocket [chemical binding]; other site 272568005180 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 272568005181 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272568005182 CTP synthetase; Validated; Region: pyrG; PRK05380 272568005183 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272568005184 Catalytic site [active] 272568005185 active site 272568005186 UTP binding site [chemical binding]; other site 272568005187 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272568005188 active site 272568005189 putative oxyanion hole; other site 272568005190 catalytic triad [active] 272568005191 triosephosphate isomerase; Provisional; Region: PRK14565 272568005192 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272568005193 substrate binding site [chemical binding]; other site 272568005194 dimer interface [polypeptide binding]; other site 272568005195 catalytic triad [active] 272568005196 SurA N-terminal domain; Region: SurA_N_3; cl07813 272568005197 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 272568005198 anthranilate synthase component I; Provisional; Region: PRK13573 272568005199 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272568005200 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272568005201 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272568005202 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272568005203 glutamine binding [chemical binding]; other site 272568005204 catalytic triad [active] 272568005205 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272568005206 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272568005207 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272568005208 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272568005209 active site 272568005210 ribulose/triose binding site [chemical binding]; other site 272568005211 phosphate binding site [ion binding]; other site 272568005212 substrate (anthranilate) binding pocket [chemical binding]; other site 272568005213 product (indole) binding pocket [chemical binding]; other site 272568005214 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 272568005215 trimer interface [polypeptide binding]; other site 272568005216 dimer interface [polypeptide binding]; other site 272568005217 putative active site [active] 272568005218 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 272568005219 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272568005220 tetramer interface [polypeptide binding]; other site 272568005221 TPP-binding site [chemical binding]; other site 272568005222 heterodimer interface [polypeptide binding]; other site 272568005223 phosphorylation loop region [posttranslational modification] 272568005224 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 272568005225 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272568005226 E3 interaction surface; other site 272568005227 lipoyl attachment site [posttranslational modification]; other site 272568005228 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272568005229 alpha subunit interface [polypeptide binding]; other site 272568005230 TPP binding site [chemical binding]; other site 272568005231 heterodimer interface [polypeptide binding]; other site 272568005232 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272568005233 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272568005234 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 272568005235 E3 interaction surface; other site 272568005236 lipoyl attachment site [posttranslational modification]; other site 272568005237 e3 binding domain; Region: E3_binding; pfam02817 272568005238 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272568005239 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272568005240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568005241 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272568005242 lipoyl synthase; Provisional; Region: PRK05481 272568005243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568005244 FeS/SAM binding site; other site 272568005245 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 272568005246 putative coenzyme Q binding site [chemical binding]; other site 272568005247 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 272568005248 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 272568005249 heme-binding site [chemical binding]; other site 272568005250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272568005251 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272568005252 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568005253 dimer interface [polypeptide binding]; other site 272568005254 putative CheW interface [polypeptide binding]; other site 272568005255 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272568005256 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568005257 N-terminal plug; other site 272568005258 ligand-binding site [chemical binding]; other site 272568005259 Competence-damaged protein; Region: CinA; pfam02464 272568005260 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 272568005261 tetramer interfaces [polypeptide binding]; other site 272568005262 binuclear metal-binding site [ion binding]; other site 272568005263 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568005264 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568005265 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568005266 catalytic residue [active] 272568005267 Integral membrane protein TerC family; Region: TerC; cl10468 272568005268 adenylosuccinate lyase; Provisional; Region: PRK07492 272568005269 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272568005270 tetramer interface [polypeptide binding]; other site 272568005271 active site 272568005272 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 272568005273 NRDE protein; Region: NRDE; cl01315 272568005274 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 272568005275 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272568005276 ATP binding site [chemical binding]; other site 272568005277 active site 272568005278 substrate binding site [chemical binding]; other site 272568005279 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 272568005280 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 272568005281 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272568005282 conserved cys residue [active] 272568005283 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272568005284 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272568005285 dimerization interface [polypeptide binding]; other site 272568005286 ATP binding site [chemical binding]; other site 272568005287 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272568005288 dimerization interface [polypeptide binding]; other site 272568005289 ATP binding site [chemical binding]; other site 272568005290 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 272568005291 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 272568005292 putative GSH binding site [chemical binding]; other site 272568005293 catalytic residues [active] 272568005294 hypothetical protein; Reviewed; Region: PRK12497 272568005295 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 272568005296 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 272568005297 putative active site [active] 272568005298 catalytic site [active] 272568005299 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 272568005300 putative active site [active] 272568005301 catalytic site [active] 272568005302 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272568005303 putative catalytic site [active] 272568005304 putative metal binding site [ion binding]; other site 272568005305 putative phosphate binding site [ion binding]; other site 272568005306 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272568005307 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272568005308 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272568005309 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272568005310 active site residue [active] 272568005311 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272568005312 active site residue [active] 272568005313 cystathionine beta-lyase; Provisional; Region: PRK05967 272568005314 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568005315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568005316 catalytic residue [active] 272568005317 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272568005318 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272568005319 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272568005320 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 272568005321 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 272568005322 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272568005323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568005324 non-specific DNA binding site [nucleotide binding]; other site 272568005325 salt bridge; other site 272568005326 sequence-specific DNA binding site [nucleotide binding]; other site 272568005327 NmrA-like family; Region: NmrA; pfam05368 272568005328 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 272568005329 NADP binding site [chemical binding]; other site 272568005330 active site 272568005331 regulatory binding site [polypeptide binding]; other site 272568005332 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 272568005333 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 272568005334 Predicted transcriptional regulators [Transcription]; Region: COG1695 272568005335 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272568005336 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 272568005337 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 272568005338 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 272568005339 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 272568005340 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272568005341 Winged helix-turn helix; Region: HTH_29; pfam13551 272568005342 Integrase core domain; Region: rve; pfam00665 272568005343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568005344 Integrase core domain; Region: rve_3; pfam13683 272568005345 Autotransporter beta-domain; Region: Autotransporter; smart00869 272568005346 Survival protein SurE; Region: SurE; cl00448 272568005347 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272568005348 MPN+ (JAMM) motif; other site 272568005349 Zinc-binding site [ion binding]; other site 272568005350 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272568005351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568005352 motif II; other site 272568005353 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 272568005354 RadC-like JAB domain; Region: RadC; pfam04002 272568005355 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272568005356 Part of AAA domain; Region: AAA_19; pfam13245 272568005357 Family description; Region: UvrD_C_2; pfam13538 272568005358 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272568005359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568005360 S-adenosylmethionine binding site [chemical binding]; other site 272568005361 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272568005362 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272568005363 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 272568005364 active site 272568005365 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 272568005366 isocitrate dehydrogenase; Validated; Region: PRK06451 272568005367 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 272568005368 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 272568005369 active site 272568005370 homotetramer interface [polypeptide binding]; other site 272568005371 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 272568005372 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 272568005373 active site 272568005374 catalytic site [active] 272568005375 tetramer interface [polypeptide binding]; other site 272568005376 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272568005377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568005378 catalytic residue [active] 272568005379 allantoate amidohydrolase; Reviewed; Region: PRK09290 272568005380 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272568005381 active site 272568005382 metal binding site [ion binding]; metal-binding site 272568005383 dimer interface [polypeptide binding]; other site 272568005384 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272568005385 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 272568005386 amidase; Provisional; Region: PRK09201 272568005387 Amidase; Region: Amidase; pfam01425 272568005388 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 272568005389 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 272568005390 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 272568005391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568005392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568005393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568005394 dimerization interface [polypeptide binding]; other site 272568005395 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 272568005396 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 272568005397 XdhC Rossmann domain; Region: XdhC_C; pfam13478 272568005398 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 272568005399 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272568005400 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272568005401 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 272568005402 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272568005403 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 272568005404 phenylhydantoinase; Validated; Region: PRK08323 272568005405 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 272568005406 tetramer interface [polypeptide binding]; other site 272568005407 active site 272568005408 allantoate amidohydrolase; Reviewed; Region: PRK09290 272568005409 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272568005410 active site 272568005411 metal binding site [ion binding]; metal-binding site 272568005412 dimer interface [polypeptide binding]; other site 272568005413 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 272568005414 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272568005415 inhibitor-cofactor binding pocket; inhibition site 272568005416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568005417 catalytic residue [active] 272568005418 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 272568005419 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 272568005420 Na binding site [ion binding]; other site 272568005421 putative substrate binding site [chemical binding]; other site 272568005422 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 272568005423 exopolyphosphatase; Region: exo_poly_only; TIGR03706 272568005424 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 272568005425 polyphosphate kinase; Provisional; Region: PRK05443 272568005426 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272568005427 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272568005428 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 272568005429 putative domain interface [polypeptide binding]; other site 272568005430 putative active site [active] 272568005431 catalytic site [active] 272568005432 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 272568005433 putative domain interface [polypeptide binding]; other site 272568005434 putative active site [active] 272568005435 catalytic site [active] 272568005436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272568005437 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 272568005438 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272568005439 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272568005440 dimerization interface [polypeptide binding]; other site 272568005441 putative ATP binding site [chemical binding]; other site 272568005442 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 272568005443 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272568005444 active site 272568005445 substrate binding site [chemical binding]; other site 272568005446 cosubstrate binding site; other site 272568005447 catalytic site [active] 272568005448 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272568005449 active site 272568005450 multimer interface [polypeptide binding]; other site 272568005451 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272568005452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568005453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568005454 ABC transporter; Region: ABC_tran_2; pfam12848 272568005455 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568005456 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272568005457 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 272568005458 multidrug resistance protein MdtN; Provisional; Region: PRK10476 272568005459 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568005460 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568005461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272568005462 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272568005463 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 272568005464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568005465 active site 272568005466 motif I; other site 272568005467 motif II; other site 272568005468 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272568005469 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272568005470 inhibitor-cofactor binding pocket; inhibition site 272568005471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568005472 catalytic residue [active] 272568005473 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 272568005474 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 272568005475 NAD(P) binding site [chemical binding]; other site 272568005476 homodimer interface [polypeptide binding]; other site 272568005477 substrate binding site [chemical binding]; other site 272568005478 active site 272568005479 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272568005480 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 272568005481 Mg++ binding site [ion binding]; other site 272568005482 putative catalytic motif [active] 272568005483 putative substrate binding site [chemical binding]; other site 272568005484 MarR family; Region: MarR; pfam01047 272568005485 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272568005486 interface (dimer of trimers) [polypeptide binding]; other site 272568005487 Substrate-binding/catalytic site; other site 272568005488 Zn-binding sites [ion binding]; other site 272568005489 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272568005490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568005491 nucleotide binding region [chemical binding]; other site 272568005492 ATP-binding site [chemical binding]; other site 272568005493 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272568005494 RNA binding surface [nucleotide binding]; other site 272568005495 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272568005496 4Fe-4S binding domain; Region: Fer4; cl02805 272568005497 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 272568005498 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 272568005499 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 272568005500 Subunit I/III interface [polypeptide binding]; other site 272568005501 Subunit III/IV interface [polypeptide binding]; other site 272568005502 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272568005503 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272568005504 D-pathway; other site 272568005505 Putative ubiquinol binding site [chemical binding]; other site 272568005506 Low-spin heme (heme b) binding site [chemical binding]; other site 272568005507 Putative water exit pathway; other site 272568005508 Binuclear center (heme o3/CuB) [ion binding]; other site 272568005509 K-pathway; other site 272568005510 Putative proton exit pathway; other site 272568005511 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 272568005512 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272568005513 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 272568005514 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 272568005515 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272568005516 Winged helix-turn helix; Region: HTH_29; pfam13551 272568005517 Integrase core domain; Region: rve; pfam00665 272568005518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568005519 Integrase core domain; Region: rve_3; pfam13683 272568005520 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 272568005521 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272568005522 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 272568005523 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 272568005524 Trp docking motif [polypeptide binding]; other site 272568005525 cytochrome domain interface [polypeptide binding]; other site 272568005526 active site 272568005527 Cytochrome c; Region: Cytochrom_C; pfam00034 272568005528 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568005529 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568005530 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272568005531 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 272568005532 NAD-dependent deacetylase; Provisional; Region: PRK00481 272568005533 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 272568005534 putative uracil binding site [chemical binding]; other site 272568005535 putative active site [active] 272568005536 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 272568005537 Predicted integral membrane protein [Function unknown]; Region: COG0392 272568005538 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 272568005539 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 272568005540 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272568005541 active site 272568005542 nucleotide binding site [chemical binding]; other site 272568005543 HIGH motif; other site 272568005544 KMSKS motif; other site 272568005545 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272568005546 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272568005547 DNA-binding site [nucleotide binding]; DNA binding site 272568005548 RNA-binding motif; other site 272568005549 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272568005550 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272568005551 ring oligomerisation interface [polypeptide binding]; other site 272568005552 ATP/Mg binding site [chemical binding]; other site 272568005553 stacking interactions; other site 272568005554 hinge regions; other site 272568005555 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272568005556 oligomerisation interface [polypeptide binding]; other site 272568005557 mobile loop; other site 272568005558 roof hairpin; other site 272568005559 Usg-like family; Region: Usg; cl11567 272568005560 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 272568005561 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272568005562 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 272568005563 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 272568005564 Cytochrome c; Region: Cytochrom_C; cl11414 272568005565 cytochrome b; Provisional; Region: CYTB; MTH00145 272568005566 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 272568005567 Qi binding site; other site 272568005568 intrachain domain interface; other site 272568005569 interchain domain interface [polypeptide binding]; other site 272568005570 heme bH binding site [chemical binding]; other site 272568005571 heme bL binding site [chemical binding]; other site 272568005572 Qo binding site; other site 272568005573 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 272568005574 interchain domain interface [polypeptide binding]; other site 272568005575 intrachain domain interface; other site 272568005576 Qi binding site; other site 272568005577 Qo binding site; other site 272568005578 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 272568005579 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 272568005580 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272568005581 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272568005582 Walker A/P-loop; other site 272568005583 ATP binding site [chemical binding]; other site 272568005584 Q-loop/lid; other site 272568005585 ABC transporter signature motif; other site 272568005586 Walker B; other site 272568005587 D-loop; other site 272568005588 H-loop/switch region; other site 272568005589 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 272568005590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272568005591 ABC-ATPase subunit interface; other site 272568005592 dimer interface [polypeptide binding]; other site 272568005593 putative PBP binding regions; other site 272568005594 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 272568005595 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 272568005596 putative ligand binding residues [chemical binding]; other site 272568005597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 272568005598 Smr domain; Region: Smr; pfam01713 272568005599 Haem-binding domain; Region: Haem_bd; pfam14376 272568005600 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 272568005601 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272568005602 DNA methylase; Region: N6_N4_Mtase; pfam01555 272568005603 MltA specific insert domain; Region: MltA; smart00925 272568005604 3D domain; Region: 3D; pfam06725 272568005605 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 272568005606 preprotein translocase subunit SecB; Validated; Region: PRK05751 272568005607 SecA binding site; other site 272568005608 Preprotein binding site; other site 272568005609 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272568005610 active site 272568005611 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272568005612 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 272568005613 domain interfaces; other site 272568005614 active site 272568005615 UGMP family protein; Validated; Region: PRK09604 272568005616 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272568005617 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 272568005618 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272568005619 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272568005620 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272568005621 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 272568005622 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 272568005623 Nucleoside recognition; Region: Gate; pfam07670 272568005624 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 272568005625 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272568005626 catalytic residues [active] 272568005627 dimer interface [polypeptide binding]; other site 272568005628 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272568005629 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272568005630 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272568005631 MutS domain I; Region: MutS_I; pfam01624 272568005632 MutS domain II; Region: MutS_II; pfam05188 272568005633 MutS domain III; Region: MutS_III; pfam05192 272568005634 MutS domain V; Region: MutS_V; pfam00488 272568005635 Walker A/P-loop; other site 272568005636 ATP binding site [chemical binding]; other site 272568005637 Q-loop/lid; other site 272568005638 ABC transporter signature motif; other site 272568005639 Walker B; other site 272568005640 D-loop; other site 272568005641 H-loop/switch region; other site 272568005642 PII uridylyl-transferase; Provisional; Region: PRK05092 272568005643 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272568005644 metal binding triad; other site 272568005645 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272568005646 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 272568005647 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 272568005648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568005649 binding surface 272568005650 TPR motif; other site 272568005651 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568005652 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 272568005653 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 272568005654 active site 272568005655 Zn binding site [ion binding]; other site 272568005656 Hint domain; Region: Hint_2; pfam13403 272568005657 Major royal jelly protein; Region: MRJP; pfam03022 272568005658 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 272568005659 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 272568005660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568005661 catalytic residue [active] 272568005662 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272568005663 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272568005664 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272568005665 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272568005666 Tim44-like domain; Region: Tim44; pfam04280 272568005667 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568005668 Winged helix-turn helix; Region: HTH_29; pfam13551 272568005669 Homeodomain-like domain; Region: HTH_32; pfam13565 272568005670 Winged helix-turn helix; Region: HTH_33; pfam13592 272568005671 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 272568005672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568005673 Walker A motif; other site 272568005674 ATP binding site [chemical binding]; other site 272568005675 Walker B motif; other site 272568005676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568005677 Integrase core domain; Region: rve; pfam00665 272568005678 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 272568005679 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 272568005680 UbiA prenyltransferase family; Region: UbiA; pfam01040 272568005681 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 272568005682 Low-spin heme binding site [chemical binding]; other site 272568005683 D-pathway; other site 272568005684 Binuclear center (active site) [active] 272568005685 K-pathway; other site 272568005686 Putative proton exit pathway; other site 272568005687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568005688 S-adenosylmethionine binding site [chemical binding]; other site 272568005689 glutathione synthetase; Provisional; Region: PRK05246 272568005690 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 272568005691 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 272568005692 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 272568005693 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272568005694 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272568005695 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 272568005696 active site 272568005697 catalytic residues [active] 272568005698 excinuclease ABC subunit B; Provisional; Region: PRK05298 272568005699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272568005700 ATP binding site [chemical binding]; other site 272568005701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568005702 nucleotide binding region [chemical binding]; other site 272568005703 ATP-binding site [chemical binding]; other site 272568005704 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272568005705 exodeoxyribonuclease X; Provisional; Region: PRK07983 272568005706 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272568005707 active site 272568005708 catalytic site [active] 272568005709 substrate binding site [chemical binding]; other site 272568005710 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272568005711 ABC1 family; Region: ABC1; cl17513 272568005712 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272568005713 active site 272568005714 ATP binding site [chemical binding]; other site 272568005715 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 272568005716 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 272568005717 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 272568005718 active site 272568005719 Zn binding site [ion binding]; other site 272568005720 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272568005721 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272568005722 active site 272568005723 dimer interface [polypeptide binding]; other site 272568005724 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272568005725 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272568005726 active site 272568005727 FMN binding site [chemical binding]; other site 272568005728 substrate binding site [chemical binding]; other site 272568005729 3Fe-4S cluster binding site [ion binding]; other site 272568005730 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272568005731 domain interface; other site 272568005732 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 272568005733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568005734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568005735 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 272568005736 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272568005737 putative NAD(P) binding site [chemical binding]; other site 272568005738 active site 272568005739 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272568005740 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272568005741 catalytic site [active] 272568005742 putative active site [active] 272568005743 putative substrate binding site [chemical binding]; other site 272568005744 KpsF/GutQ family protein; Region: kpsF; TIGR00393 272568005745 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272568005746 putative active site [active] 272568005747 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 272568005748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 272568005749 OstA-like protein; Region: OstA; cl00844 272568005750 OstA-like protein; Region: OstA; cl00844 272568005751 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 272568005752 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 272568005753 Walker A/P-loop; other site 272568005754 ATP binding site [chemical binding]; other site 272568005755 Q-loop/lid; other site 272568005756 ABC transporter signature motif; other site 272568005757 Walker B; other site 272568005758 D-loop; other site 272568005759 H-loop/switch region; other site 272568005760 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 272568005761 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272568005762 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272568005763 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272568005764 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272568005765 30S subunit binding site; other site 272568005766 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 272568005767 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272568005768 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272568005769 putative dimer interface [polypeptide binding]; other site 272568005770 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 272568005771 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 272568005772 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 272568005773 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 272568005774 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272568005775 active site 272568005776 catalytic residues [active] 272568005777 metal binding site [ion binding]; metal-binding site 272568005778 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272568005779 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272568005780 putative active site [active] 272568005781 substrate binding site [chemical binding]; other site 272568005782 putative cosubstrate binding site; other site 272568005783 catalytic site [active] 272568005784 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272568005785 substrate binding site [chemical binding]; other site 272568005786 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272568005787 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272568005788 dimerization interface 3.5A [polypeptide binding]; other site 272568005789 active site 272568005790 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 272568005791 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 272568005792 metal binding site [ion binding]; metal-binding site 272568005793 dimer interface [polypeptide binding]; other site 272568005794 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 272568005795 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272568005796 trimer interface [polypeptide binding]; other site 272568005797 active site 272568005798 substrate binding site [chemical binding]; other site 272568005799 CoA binding site [chemical binding]; other site 272568005800 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272568005801 feedback inhibition sensing region; other site 272568005802 homohexameric interface [polypeptide binding]; other site 272568005803 nucleotide binding site [chemical binding]; other site 272568005804 N-acetyl-L-glutamate binding site [chemical binding]; other site 272568005805 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272568005806 G1 box; other site 272568005807 GTP/Mg2+ binding site [chemical binding]; other site 272568005808 Switch I region; other site 272568005809 G2 box; other site 272568005810 G3 box; other site 272568005811 Switch II region; other site 272568005812 G4 box; other site 272568005813 G5 box; other site 272568005814 membrane protein insertase; Provisional; Region: PRK01318 272568005815 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272568005816 Ribonuclease P; Region: Ribonuclease_P; pfam00825 272568005817 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272568005818 dimer interface [polypeptide binding]; other site 272568005819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568005820 active site 272568005821 metal binding site [ion binding]; metal-binding site 272568005822 glutathione binding site [chemical binding]; other site 272568005823 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 272568005824 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 272568005825 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272568005826 active site 272568005827 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272568005828 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272568005829 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272568005830 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272568005831 trimer interface [polypeptide binding]; other site 272568005832 active site 272568005833 UDP-GlcNAc binding site [chemical binding]; other site 272568005834 lipid binding site [chemical binding]; lipid-binding site 272568005835 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 272568005836 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 272568005837 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272568005838 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272568005839 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272568005840 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272568005841 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272568005842 Surface antigen; Region: Bac_surface_Ag; pfam01103 272568005843 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 272568005844 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272568005845 active site 272568005846 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272568005847 protein binding site [polypeptide binding]; other site 272568005848 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272568005849 putative substrate binding region [chemical binding]; other site 272568005850 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272568005851 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272568005852 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272568005853 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272568005854 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 272568005855 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272568005856 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 272568005857 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 272568005858 catalytic residue [active] 272568005859 putative FPP diphosphate binding site; other site 272568005860 putative FPP binding hydrophobic cleft; other site 272568005861 dimer interface [polypeptide binding]; other site 272568005862 putative IPP diphosphate binding site; other site 272568005863 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272568005864 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272568005865 hinge region; other site 272568005866 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272568005867 putative nucleotide binding site [chemical binding]; other site 272568005868 uridine monophosphate binding site [chemical binding]; other site 272568005869 homohexameric interface [polypeptide binding]; other site 272568005870 GTPase Era; Reviewed; Region: era; PRK00089 272568005871 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272568005872 G1 box; other site 272568005873 GTP/Mg2+ binding site [chemical binding]; other site 272568005874 Switch I region; other site 272568005875 G2 box; other site 272568005876 Switch II region; other site 272568005877 G3 box; other site 272568005878 G4 box; other site 272568005879 G5 box; other site 272568005880 KH domain; Region: KH_2; pfam07650 272568005881 G-X-X-G motif; other site 272568005882 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 272568005883 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272568005884 dimerization interface [polypeptide binding]; other site 272568005885 active site 272568005886 metal binding site [ion binding]; metal-binding site 272568005887 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272568005888 dsRNA binding site [nucleotide binding]; other site 272568005889 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272568005890 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272568005891 Catalytic site [active] 272568005892 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272568005893 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272568005894 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272568005895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272568005896 Zn2+ binding site [ion binding]; other site 272568005897 Mg2+ binding site [ion binding]; other site 272568005898 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272568005899 synthetase active site [active] 272568005900 NTP binding site [chemical binding]; other site 272568005901 metal binding site [ion binding]; metal-binding site 272568005902 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272568005903 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272568005904 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272568005905 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272568005906 catalytic center binding site [active] 272568005907 ATP binding site [chemical binding]; other site 272568005908 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272568005909 LabA_like proteins; Region: LabA; cd10911 272568005910 putative metal binding site [ion binding]; other site 272568005911 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 272568005912 Fe-S cluster binding site [ion binding]; other site 272568005913 DNA binding site [nucleotide binding] 272568005914 active site 272568005915 malate:quinone oxidoreductase; Validated; Region: PRK05257 272568005916 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 272568005917 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 272568005918 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 272568005919 TMAO/DMSO reductase; Reviewed; Region: PRK05363 272568005920 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272568005921 Moco binding site; other site 272568005922 metal coordination site [ion binding]; other site 272568005923 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272568005924 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272568005925 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 272568005926 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272568005927 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272568005928 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272568005929 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272568005930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568005931 putative substrate translocation pore; other site 272568005932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568005933 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 272568005934 classical (c) SDRs; Region: SDR_c; cd05233 272568005935 NAD(P) binding site [chemical binding]; other site 272568005936 active site 272568005937 galactonate dehydratase; Provisional; Region: PRK14017 272568005938 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 272568005939 putative active site pocket [active] 272568005940 putative metal binding site [ion binding]; other site 272568005941 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 272568005942 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272568005943 active site 272568005944 intersubunit interface [polypeptide binding]; other site 272568005945 catalytic residue [active] 272568005946 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 272568005947 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 272568005948 Transcriptional regulator [Transcription]; Region: IclR; COG1414 272568005949 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 272568005950 Bacterial transcriptional regulator; Region: IclR; pfam01614 272568005951 Preprotein translocase subunit; Region: YajC; pfam02699 272568005952 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 272568005953 Protein of unknown function (DUF815); Region: DUF815; pfam05673 272568005954 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272568005955 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272568005956 [2Fe-2S] cluster binding site [ion binding]; other site 272568005957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272568005958 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272568005959 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 272568005960 active site 272568005961 8-oxo-dGMP binding site [chemical binding]; other site 272568005962 nudix motif; other site 272568005963 metal binding site [ion binding]; metal-binding site 272568005964 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 272568005965 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 272568005966 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272568005967 putative MPT binding site; other site 272568005968 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272568005969 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 272568005970 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 272568005971 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272568005972 active site 272568005973 DNA binding site [nucleotide binding] 272568005974 Int/Topo IB signature motif; other site 272568005975 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272568005976 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 272568005977 ADP binding site [chemical binding]; other site 272568005978 magnesium binding site [ion binding]; other site 272568005979 putative shikimate binding site; other site 272568005980 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272568005981 active site 272568005982 dimer interface [polypeptide binding]; other site 272568005983 metal binding site [ion binding]; metal-binding site 272568005984 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272568005985 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272568005986 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272568005987 ligand binding site [chemical binding]; other site 272568005988 Putative transcription activator [Transcription]; Region: TenA; COG0819 272568005989 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272568005990 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272568005991 motif 1; other site 272568005992 active site 272568005993 motif 2; other site 272568005994 motif 3; other site 272568005995 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272568005996 DHHA1 domain; Region: DHHA1; pfam02272 272568005997 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 272568005998 active site clefts [active] 272568005999 zinc binding site [ion binding]; other site 272568006000 dimer interface [polypeptide binding]; other site 272568006001 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272568006002 putative catalytic site [active] 272568006003 putative metal binding site [ion binding]; other site 272568006004 putative phosphate binding site [ion binding]; other site 272568006005 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568006006 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568006007 active site 272568006008 catalytic tetrad [active] 272568006009 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272568006010 nudix motif; other site 272568006011 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 272568006012 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 272568006013 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272568006014 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272568006015 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272568006016 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272568006017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272568006018 RNA binding surface [nucleotide binding]; other site 272568006019 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 272568006020 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272568006021 G1 box; other site 272568006022 GTP/Mg2+ binding site [chemical binding]; other site 272568006023 G2 box; other site 272568006024 Switch I region; other site 272568006025 G3 box; other site 272568006026 Switch II region; other site 272568006027 G4 box; other site 272568006028 G5 box; other site 272568006029 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272568006030 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 272568006031 cation binding site [ion binding]; other site 272568006032 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272568006033 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272568006034 active site 272568006035 HIGH motif; other site 272568006036 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272568006037 KMSKS motif; other site 272568006038 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272568006039 tRNA binding surface [nucleotide binding]; other site 272568006040 anticodon binding site; other site 272568006041 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 272568006042 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272568006043 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 272568006044 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 272568006045 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 272568006046 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 272568006047 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 272568006048 CT1975-like protein; Region: Cas_CT1975; pfam09344 272568006049 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 272568006050 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 272568006051 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 272568006052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272568006053 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 272568006054 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 272568006055 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272568006056 active site 272568006057 HIGH motif; other site 272568006058 nucleotide binding site [chemical binding]; other site 272568006059 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272568006060 active site 272568006061 KMSKS motif; other site 272568006062 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 272568006063 active site 272568006064 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 272568006065 glutathione reductase; Validated; Region: PRK06116 272568006066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568006067 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272568006068 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272568006069 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 272568006070 FAD binding pocket [chemical binding]; other site 272568006071 FAD binding motif [chemical binding]; other site 272568006072 phosphate binding motif [ion binding]; other site 272568006073 beta-alpha-beta structure motif; other site 272568006074 NAD binding pocket [chemical binding]; other site 272568006075 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272568006076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272568006077 ATP binding site [chemical binding]; other site 272568006078 putative Mg++ binding site [ion binding]; other site 272568006079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568006080 nucleotide binding region [chemical binding]; other site 272568006081 ATP-binding site [chemical binding]; other site 272568006082 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 272568006083 seryl-tRNA synthetase; Provisional; Region: PRK05431 272568006084 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272568006085 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272568006086 dimer interface [polypeptide binding]; other site 272568006087 active site 272568006088 motif 1; other site 272568006089 motif 2; other site 272568006090 motif 3; other site 272568006091 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 272568006092 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 272568006093 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 272568006094 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 272568006095 Sporulation related domain; Region: SPOR; pfam05036 272568006096 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272568006097 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 272568006098 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272568006099 active site 272568006100 HIGH motif; other site 272568006101 nucleotide binding site [chemical binding]; other site 272568006102 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272568006103 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272568006104 KMSK motif region; other site 272568006105 tRNA binding surface [nucleotide binding]; other site 272568006106 DALR anticodon binding domain; Region: DALR_1; smart00836 272568006107 anticodon binding site; other site 272568006108 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 272568006109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272568006110 Zn2+ binding site [ion binding]; other site 272568006111 Mg2+ binding site [ion binding]; other site 272568006112 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272568006113 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 272568006114 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272568006115 putative catalytic site [active] 272568006116 putative phosphate binding site [ion binding]; other site 272568006117 active site 272568006118 metal binding site A [ion binding]; metal-binding site 272568006119 DNA binding site [nucleotide binding] 272568006120 putative AP binding site [nucleotide binding]; other site 272568006121 putative metal binding site B [ion binding]; other site 272568006122 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272568006123 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 272568006124 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272568006125 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272568006126 dimer interface [polypeptide binding]; other site 272568006127 anticodon binding site; other site 272568006128 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272568006129 homodimer interface [polypeptide binding]; other site 272568006130 motif 1; other site 272568006131 active site 272568006132 motif 2; other site 272568006133 GAD domain; Region: GAD; pfam02938 272568006134 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272568006135 active site 272568006136 motif 3; other site 272568006137 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 272568006138 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 272568006139 heat shock protein 90; Provisional; Region: PRK05218 272568006140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568006141 ATP binding site [chemical binding]; other site 272568006142 Mg2+ binding site [ion binding]; other site 272568006143 G-X-G motif; other site 272568006144 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 272568006145 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 272568006146 nudix motif; other site 272568006147 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 272568006148 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272568006149 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 272568006150 heme-binding site [chemical binding]; other site 272568006151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568006152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568006153 metal binding site [ion binding]; metal-binding site 272568006154 active site 272568006155 I-site; other site 272568006156 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 272568006157 Peptidase family M50; Region: Peptidase_M50; pfam02163 272568006158 active site 272568006159 putative substrate binding region [chemical binding]; other site 272568006160 FOG: CBS domain [General function prediction only]; Region: COG0517 272568006161 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272568006162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568006163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568006164 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 272568006165 putative substrate binding pocket [chemical binding]; other site 272568006166 putative dimerization interface [polypeptide binding]; other site 272568006167 MobA/MobL family; Region: MobA_MobL; pfam03389 272568006168 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272568006169 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272568006170 catalytic residues [active] 272568006171 catalytic nucleophile [active] 272568006172 Presynaptic Site I dimer interface [polypeptide binding]; other site 272568006173 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272568006174 Synaptic Flat tetramer interface [polypeptide binding]; other site 272568006175 Synaptic Site I dimer interface [polypeptide binding]; other site 272568006176 DNA binding site [nucleotide binding] 272568006177 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272568006178 DNA-binding interface [nucleotide binding]; DNA binding site 272568006179 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272568006180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568006181 non-specific DNA binding site [nucleotide binding]; other site 272568006182 salt bridge; other site 272568006183 sequence-specific DNA binding site [nucleotide binding]; other site 272568006184 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272568006185 Helix-turn-helix domain; Region: HTH_17; pfam12728 272568006186 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272568006187 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272568006188 active site 272568006189 DNA binding site [nucleotide binding] 272568006190 Int/Topo IB signature motif; other site 272568006191 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272568006192 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272568006193 RNA binding surface [nucleotide binding]; other site 272568006194 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272568006195 active site 272568006196 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 272568006197 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272568006198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272568006199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272568006200 DNA binding residues [nucleotide binding] 272568006201 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272568006202 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272568006203 GDP-binding site [chemical binding]; other site 272568006204 ACT binding site; other site 272568006205 IMP binding site; other site 272568006206 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 272568006207 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272568006208 dimer interface [polypeptide binding]; other site 272568006209 motif 1; other site 272568006210 active site 272568006211 motif 2; other site 272568006212 motif 3; other site 272568006213 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 272568006214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568006215 catalytic residue [active] 272568006216 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 272568006217 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272568006218 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 272568006219 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 272568006220 homodimer interface [polypeptide binding]; other site 272568006221 metal binding site [ion binding]; metal-binding site 272568006222 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 272568006223 homodimer interface [polypeptide binding]; other site 272568006224 active site 272568006225 putative chemical substrate binding site [chemical binding]; other site 272568006226 metal binding site [ion binding]; metal-binding site 272568006227 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 272568006228 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272568006229 active site 272568006230 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272568006231 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272568006232 HflX GTPase family; Region: HflX; cd01878 272568006233 G1 box; other site 272568006234 GTP/Mg2+ binding site [chemical binding]; other site 272568006235 Switch I region; other site 272568006236 G2 box; other site 272568006237 G3 box; other site 272568006238 Switch II region; other site 272568006239 G4 box; other site 272568006240 G5 box; other site 272568006241 bacterial Hfq-like; Region: Hfq; cd01716 272568006242 hexamer interface [polypeptide binding]; other site 272568006243 Sm1 motif; other site 272568006244 RNA binding site [nucleotide binding]; other site 272568006245 Sm2 motif; other site 272568006246 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272568006247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568006248 active site 272568006249 phosphorylation site [posttranslational modification] 272568006250 intermolecular recognition site; other site 272568006251 dimerization interface [polypeptide binding]; other site 272568006252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568006253 Walker A motif; other site 272568006254 ATP binding site [chemical binding]; other site 272568006255 Walker B motif; other site 272568006256 arginine finger; other site 272568006257 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272568006258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272568006259 dimerization interface [polypeptide binding]; other site 272568006260 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272568006261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568006262 dimer interface [polypeptide binding]; other site 272568006263 phosphorylation site [posttranslational modification] 272568006264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568006265 ATP binding site [chemical binding]; other site 272568006266 Mg2+ binding site [ion binding]; other site 272568006267 G-X-G motif; other site 272568006268 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 272568006269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568006270 active site 272568006271 phosphorylation site [posttranslational modification] 272568006272 intermolecular recognition site; other site 272568006273 dimerization interface [polypeptide binding]; other site 272568006274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568006275 Walker A motif; other site 272568006276 ATP binding site [chemical binding]; other site 272568006277 Walker B motif; other site 272568006278 arginine finger; other site 272568006279 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 272568006280 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272568006281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568006282 putative active site [active] 272568006283 heme pocket [chemical binding]; other site 272568006284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568006285 dimer interface [polypeptide binding]; other site 272568006286 phosphorylation site [posttranslational modification] 272568006287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568006288 ATP binding site [chemical binding]; other site 272568006289 Mg2+ binding site [ion binding]; other site 272568006290 G-X-G motif; other site 272568006291 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272568006292 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272568006293 FMN binding site [chemical binding]; other site 272568006294 active site 272568006295 catalytic residues [active] 272568006296 substrate binding site [chemical binding]; other site 272568006297 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 272568006298 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272568006299 substrate binding site; other site 272568006300 dimer interface; other site 272568006301 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272568006302 homotrimer interaction site [polypeptide binding]; other site 272568006303 zinc binding site [ion binding]; other site 272568006304 CDP-binding sites; other site 272568006305 Winged helix-turn helix; Region: HTH_29; pfam13551 272568006306 Integrase core domain; Region: rve; pfam00665 272568006307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568006308 Integrase core domain; Region: rve_3; pfam13683 272568006309 ATP12 chaperone protein; Region: ATP12; pfam07542 272568006310 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272568006311 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272568006312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272568006313 RNA binding surface [nucleotide binding]; other site 272568006314 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272568006315 active site 272568006316 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272568006317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568006318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568006319 metal binding site [ion binding]; metal-binding site 272568006320 active site 272568006321 I-site; other site 272568006322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568006324 recombination factor protein RarA; Reviewed; Region: PRK13342 272568006325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568006326 Walker A motif; other site 272568006327 ATP binding site [chemical binding]; other site 272568006328 Walker B motif; other site 272568006329 arginine finger; other site 272568006330 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272568006331 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 272568006332 short chain dehydrogenase; Provisional; Region: PRK07454 272568006333 NADP binding site [chemical binding]; other site 272568006334 substrate binding site [chemical binding]; other site 272568006335 active site 272568006336 HI0933-like protein; Region: HI0933_like; pfam03486 272568006337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568006338 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 272568006339 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568006340 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272568006341 C-terminal domain interface [polypeptide binding]; other site 272568006342 GSH binding site (G-site) [chemical binding]; other site 272568006343 dimer interface [polypeptide binding]; other site 272568006344 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 272568006345 N-terminal domain interface [polypeptide binding]; other site 272568006346 dimer interface [polypeptide binding]; other site 272568006347 substrate binding pocket (H-site) [chemical binding]; other site 272568006348 septum formation inhibitor; Reviewed; Region: minC; PRK05177 272568006349 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272568006350 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 272568006351 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 272568006352 Switch I; other site 272568006353 Switch II; other site 272568006354 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 272568006355 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272568006356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568006357 DNA-binding site [nucleotide binding]; DNA binding site 272568006358 FCD domain; Region: FCD; pfam07729 272568006359 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272568006360 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272568006361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568006362 Walker A/P-loop; other site 272568006363 ATP binding site [chemical binding]; other site 272568006364 Q-loop/lid; other site 272568006365 ABC transporter signature motif; other site 272568006366 Walker B; other site 272568006367 D-loop; other site 272568006368 H-loop/switch region; other site 272568006369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568006370 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 272568006371 putative ADP-binding pocket [chemical binding]; other site 272568006372 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272568006373 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 272568006374 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272568006375 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272568006376 Probable Catalytic site; other site 272568006377 metal-binding site 272568006378 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 272568006379 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 272568006380 pantothenate kinase; Provisional; Region: PRK05439 272568006381 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272568006382 ATP-binding site [chemical binding]; other site 272568006383 CoA-binding site [chemical binding]; other site 272568006384 Mg2+-binding site [ion binding]; other site 272568006385 recombinase A; Provisional; Region: recA; PRK09354 272568006386 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272568006387 hexamer interface [polypeptide binding]; other site 272568006388 Walker A motif; other site 272568006389 ATP binding site [chemical binding]; other site 272568006390 Walker B motif; other site 272568006391 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 272568006392 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568006393 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272568006394 5-aminolevulinate synthase; Validated; Region: PRK09064 272568006395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568006396 catalytic residue [active] 272568006397 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272568006398 TPP-binding site [chemical binding]; other site 272568006399 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272568006400 PYR/PP interface [polypeptide binding]; other site 272568006401 dimer interface [polypeptide binding]; other site 272568006402 TPP binding site [chemical binding]; other site 272568006403 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272568006404 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272568006405 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272568006406 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272568006407 Phosphoglycerate kinase; Region: PGK; pfam00162 272568006408 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272568006409 substrate binding site [chemical binding]; other site 272568006410 hinge regions; other site 272568006411 ADP binding site [chemical binding]; other site 272568006412 catalytic site [active] 272568006413 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272568006414 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272568006415 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272568006416 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 272568006417 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272568006418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568006419 FeS/SAM binding site; other site 272568006420 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272568006421 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272568006422 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272568006423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568006424 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272568006425 dimer interface [polypeptide binding]; other site 272568006426 active site 272568006427 metal binding site [ion binding]; metal-binding site 272568006428 glutathione binding site [chemical binding]; other site 272568006429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272568006430 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272568006431 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272568006432 Walker A/P-loop; other site 272568006433 ATP binding site [chemical binding]; other site 272568006434 Q-loop/lid; other site 272568006435 ABC transporter signature motif; other site 272568006436 Walker B; other site 272568006437 D-loop; other site 272568006438 H-loop/switch region; other site 272568006439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 272568006440 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272568006441 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272568006442 putative PBP binding regions; other site 272568006443 ABC-ATPase subunit interface; other site 272568006444 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272568006445 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272568006446 intersubunit interface [polypeptide binding]; other site 272568006447 glycine dehydrogenase; Provisional; Region: PRK05367 272568006448 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568006449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568006450 catalytic residue [active] 272568006451 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272568006452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568006453 tetramer interface [polypeptide binding]; other site 272568006454 catalytic residue [active] 272568006455 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272568006456 lipoyl attachment site [posttranslational modification]; other site 272568006457 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 272568006458 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272568006459 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 272568006460 spermidine synthase; Provisional; Region: PRK00811 272568006461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568006462 S-adenosylmethionine binding site [chemical binding]; other site 272568006463 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 272568006464 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272568006465 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272568006466 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272568006467 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272568006468 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272568006469 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272568006470 dimer interface [polypeptide binding]; other site 272568006471 ssDNA binding site [nucleotide binding]; other site 272568006472 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272568006473 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272568006474 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272568006475 CAP-like domain; other site 272568006476 active site 272568006477 primary dimer interface [polypeptide binding]; other site 272568006478 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272568006479 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272568006480 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272568006481 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272568006482 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272568006483 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 272568006484 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272568006485 active site 272568006486 (T/H)XGH motif; other site 272568006487 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272568006488 active site 272568006489 HAMP domain; Region: HAMP; pfam00672 272568006490 dimerization interface [polypeptide binding]; other site 272568006491 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272568006492 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568006493 dimer interface [polypeptide binding]; other site 272568006494 putative CheW interface [polypeptide binding]; other site 272568006495 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272568006496 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272568006497 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 272568006498 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272568006499 dimer interface [polypeptide binding]; other site 272568006500 motif 1; other site 272568006501 active site 272568006502 motif 2; other site 272568006503 motif 3; other site 272568006504 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272568006505 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272568006506 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272568006507 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272568006508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272568006509 rod shape-determining protein MreC; Provisional; Region: PRK13922 272568006510 Protein of unknown function (DUF972); Region: DUF972; pfam06156 272568006511 rod shape-determining protein MreC; Region: MreC; pfam04085 272568006512 rod shape-determining protein MreB; Provisional; Region: PRK13927 272568006513 MreB and similar proteins; Region: MreB_like; cd10225 272568006514 nucleotide binding site [chemical binding]; other site 272568006515 Mg binding site [ion binding]; other site 272568006516 putative protofilament interaction site [polypeptide binding]; other site 272568006517 RodZ interaction site [polypeptide binding]; other site 272568006518 2-isopropylmalate synthase; Validated; Region: PRK00915 272568006519 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 272568006520 active site 272568006521 catalytic residues [active] 272568006522 metal binding site [ion binding]; metal-binding site 272568006523 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272568006524 Chloramphenicol phosphotransferase-like protein; Region: CPT; pfam07931 272568006525 P-loop motif; other site 272568006526 ATP binding site [chemical binding]; other site 272568006527 Chloramphenicol (Cm) binding site [chemical binding]; other site 272568006528 catalytic residue [active] 272568006529 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272568006530 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272568006531 active site 272568006532 metal binding site [ion binding]; metal-binding site 272568006533 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272568006534 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272568006535 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272568006536 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272568006537 HAMP domain; Region: HAMP; pfam00672 272568006538 dimerization interface [polypeptide binding]; other site 272568006539 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272568006540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568006541 dimer interface [polypeptide binding]; other site 272568006542 putative CheW interface [polypeptide binding]; other site 272568006543 Domain of unknown function DUF87; Region: DUF87; pfam01935 272568006544 HerA helicase [Replication, recombination, and repair]; Region: COG0433 272568006545 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 272568006546 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568006547 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 272568006548 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568006549 active site 272568006550 serine acetyltransferase; Provisional; Region: cysE; PRK11132 272568006551 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 272568006552 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272568006553 trimer interface [polypeptide binding]; other site 272568006554 active site 272568006555 substrate binding site [chemical binding]; other site 272568006556 CoA binding site [chemical binding]; other site 272568006557 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 272568006558 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272568006559 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272568006560 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272568006561 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272568006562 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 272568006563 catalytic motif [active] 272568006564 Catalytic residue [active] 272568006565 Aspartyl protease; Region: Asp_protease_2; pfam13650 272568006566 inhibitor binding site; inhibition site 272568006567 catalytic motif [active] 272568006568 Catalytic residue [active] 272568006569 Active site flap [active] 272568006570 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 272568006571 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272568006572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272568006573 active site 272568006574 DNA binding site [nucleotide binding] 272568006575 Int/Topo IB signature motif; other site 272568006576 primosome assembly protein PriA; Validated; Region: PRK05580 272568006577 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272568006578 ATP binding site [chemical binding]; other site 272568006579 putative Mg++ binding site [ion binding]; other site 272568006580 hydroperoxidase II; Provisional; Region: katE; PRK11249 272568006581 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 272568006582 heme binding pocket [chemical binding]; other site 272568006583 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 272568006584 domain interactions; other site 272568006585 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 272568006586 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272568006587 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272568006588 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 272568006589 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 272568006590 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272568006591 putative ion selectivity filter; other site 272568006592 putative pore gating glutamate residue; other site 272568006593 putative H+/Cl- coupling transport residue; other site 272568006594 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272568006595 Cytochrome P450; Region: p450; pfam00067 272568006596 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272568006597 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272568006598 structural tetrad; other site 272568006599 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272568006600 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 272568006601 P-loop, Walker A motif; other site 272568006602 Base recognition motif; other site 272568006603 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272568006604 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272568006605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568006606 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 272568006607 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568006608 putative C-terminal domain interface [polypeptide binding]; other site 272568006609 putative GSH binding site (G-site) [chemical binding]; other site 272568006610 putative dimer interface [polypeptide binding]; other site 272568006611 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 272568006612 putative N-terminal domain interface [polypeptide binding]; other site 272568006613 putative dimer interface [polypeptide binding]; other site 272568006614 putative substrate binding pocket (H-site) [chemical binding]; other site 272568006615 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272568006616 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272568006617 Ligand Binding Site [chemical binding]; other site 272568006618 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272568006619 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272568006620 catalytic loop [active] 272568006621 iron binding site [ion binding]; other site 272568006622 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272568006623 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 272568006624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568006625 catalytic residue [active] 272568006626 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568006627 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568006628 catalytic residue [active] 272568006629 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568006630 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 272568006631 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272568006632 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272568006633 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272568006634 active site 272568006635 HIGH motif; other site 272568006636 dimer interface [polypeptide binding]; other site 272568006637 KMSKS motif; other site 272568006638 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 272568006639 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 272568006640 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272568006641 iron-sulfur cluster [ion binding]; other site 272568006642 [2Fe-2S] cluster binding site [ion binding]; other site 272568006643 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 272568006644 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 272568006645 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568006646 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 272568006647 putative ADP-binding pocket [chemical binding]; other site 272568006648 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 272568006649 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272568006650 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272568006651 substrate binding site [chemical binding]; other site 272568006652 hexamer interface [polypeptide binding]; other site 272568006653 metal binding site [ion binding]; metal-binding site 272568006654 NusB family; Region: NusB; pfam01029 272568006655 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 272568006656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568006657 S-adenosylmethionine binding site [chemical binding]; other site 272568006658 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272568006659 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272568006660 catalytic residue [active] 272568006661 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 272568006662 potassium uptake protein; Region: kup; TIGR00794 272568006663 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 272568006664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568006665 FeS/SAM binding site; other site 272568006666 HemN C-terminal domain; Region: HemN_C; pfam06969 272568006667 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 272568006668 active site 272568006669 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 272568006670 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568006671 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568006672 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568006673 catalytic residue [active] 272568006674 Sporulation related domain; Region: SPOR; pfam05036 272568006675 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 272568006676 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 272568006677 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 272568006678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568006679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568006680 putative substrate translocation pore; other site 272568006681 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 272568006682 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272568006683 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272568006684 HIGH motif; other site 272568006685 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272568006686 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272568006687 active site 272568006688 KMSKS motif; other site 272568006689 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272568006690 tRNA binding surface [nucleotide binding]; other site 272568006691 Lipopolysaccharide-assembly; Region: LptE; pfam04390 272568006692 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 272568006693 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272568006694 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272568006695 active site 272568006696 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272568006697 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272568006698 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 272568006699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568006700 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 272568006701 Enoylreductase; Region: PKS_ER; smart00829 272568006702 NAD(P) binding site [chemical binding]; other site 272568006703 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 272568006704 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 272568006705 NADP binding site [chemical binding]; other site 272568006706 active site 272568006707 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272568006708 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272568006709 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272568006710 substrate-cofactor binding pocket; other site 272568006711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568006712 catalytic residue [active] 272568006713 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 272568006714 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 272568006715 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272568006716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568006717 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 272568006718 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272568006719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568006720 Sulfatase; Region: Sulfatase; cl17466 272568006721 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 272568006722 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 272568006723 TPR repeat; Region: TPR_11; pfam13414 272568006724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568006725 binding surface 272568006726 TPR motif; other site 272568006727 TPR repeat; Region: TPR_11; pfam13414 272568006728 GSCFA family; Region: GSCFA; pfam08885 272568006729 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568006730 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568006731 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272568006732 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272568006733 Walker A/P-loop; other site 272568006734 ATP binding site [chemical binding]; other site 272568006735 Q-loop/lid; other site 272568006736 ABC transporter signature motif; other site 272568006737 Walker B; other site 272568006738 D-loop; other site 272568006739 H-loop/switch region; other site 272568006740 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272568006741 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 272568006742 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272568006743 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568006744 polysaccharide export protein Wza; Provisional; Region: PRK15078 272568006745 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272568006746 Inward rectifier potassium channel; Region: IRK; pfam01007 272568006747 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 272568006748 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568006749 putative metal binding site [ion binding]; other site 272568006750 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 272568006751 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 272568006752 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272568006753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568006754 putative DNA binding site [nucleotide binding]; other site 272568006755 putative Zn2+ binding site [ion binding]; other site 272568006756 AsnC family; Region: AsnC_trans_reg; pfam01037 272568006757 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 272568006758 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272568006759 active site 272568006760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272568006761 dimer interface [polypeptide binding]; other site 272568006762 substrate binding site [chemical binding]; other site 272568006763 catalytic residues [active] 272568006764 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 272568006765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272568006766 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272568006767 transposase/IS protein; Provisional; Region: PRK09183 272568006768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568006769 Walker A motif; other site 272568006770 ATP binding site [chemical binding]; other site 272568006771 Walker B motif; other site 272568006772 arginine finger; other site 272568006773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568006774 Integrase core domain; Region: rve; pfam00665 272568006775 Winged helix-turn helix; Region: HTH_29; pfam13551 272568006776 Integrase core domain; Region: rve; pfam00665 272568006777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568006778 Integrase core domain; Region: rve_3; pfam13683 272568006779 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 272568006780 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 272568006781 tetramer interface [polypeptide binding]; other site 272568006782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568006783 catalytic residue [active] 272568006784 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272568006785 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272568006786 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272568006787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568006788 DNA-binding site [nucleotide binding]; DNA binding site 272568006789 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568006790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568006791 homodimer interface [polypeptide binding]; other site 272568006792 catalytic residue [active] 272568006793 Predicted membrane protein [Function unknown]; Region: COG2860 272568006794 UPF0126 domain; Region: UPF0126; pfam03458 272568006795 UPF0126 domain; Region: UPF0126; pfam03458 272568006796 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 272568006797 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 272568006798 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 272568006799 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 272568006800 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272568006801 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 272568006802 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568006803 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272568006804 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568006805 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272568006806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568006807 Walker A/P-loop; other site 272568006808 ATP binding site [chemical binding]; other site 272568006809 Q-loop/lid; other site 272568006810 ABC transporter signature motif; other site 272568006811 Walker B; other site 272568006812 D-loop; other site 272568006813 H-loop/switch region; other site 272568006814 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272568006815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568006816 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568006817 TM-ABC transporter signature motif; other site 272568006818 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 272568006819 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272568006820 putative ligand binding site [chemical binding]; other site 272568006821 Winged helix-turn helix; Region: HTH_29; pfam13551 272568006822 Integrase core domain; Region: rve; pfam00665 272568006823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568006824 Integrase core domain; Region: rve_3; pfam13683 272568006825 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272568006826 acetyl-CoA synthetase; Provisional; Region: PRK00174 272568006827 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272568006828 acyl-activating enzyme (AAE) consensus motif; other site 272568006829 AMP binding site [chemical binding]; other site 272568006830 active site 272568006831 CoA binding site [chemical binding]; other site 272568006832 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272568006833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568006834 sequence-specific DNA binding site [nucleotide binding]; other site 272568006835 salt bridge; other site 272568006836 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 272568006837 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272568006838 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 272568006839 isocitrate lyase; Provisional; Region: PRK15063 272568006840 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272568006841 tetramer interface [polypeptide binding]; other site 272568006842 active site 272568006843 Mg2+/Mn2+ binding site [ion binding]; other site 272568006844 malate synthase G; Provisional; Region: PRK02999 272568006845 active site 272568006846 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 272568006847 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 272568006848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 272568006849 Walker A/P-loop; other site 272568006850 ATP binding site [chemical binding]; other site 272568006851 Q-loop/lid; other site 272568006852 ABC transporter signature motif; other site 272568006853 Walker B; other site 272568006854 D-loop; other site 272568006855 H-loop/switch region; other site 272568006856 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 272568006857 homotrimer interaction site [polypeptide binding]; other site 272568006858 putative active site [active] 272568006859 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272568006860 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568006861 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 272568006862 FOG: CBS domain [General function prediction only]; Region: COG0517 272568006863 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272568006864 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 272568006865 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272568006866 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 272568006867 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272568006868 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 272568006869 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272568006870 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272568006871 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 272568006872 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 272568006873 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272568006874 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272568006875 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 272568006876 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 272568006877 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272568006878 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 272568006879 catalytic loop [active] 272568006880 iron binding site [ion binding]; other site 272568006881 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 272568006882 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 272568006883 [4Fe-4S] binding site [ion binding]; other site 272568006884 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 272568006885 molybdopterin cofactor binding site; other site 272568006886 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 272568006887 SLBB domain; Region: SLBB; pfam10531 272568006888 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 272568006889 NADH dehydrogenase subunit E; Validated; Region: PRK07539 272568006890 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272568006891 putative dimer interface [polypeptide binding]; other site 272568006892 [2Fe-2S] cluster binding site [ion binding]; other site 272568006893 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 272568006894 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 272568006895 NADH dehydrogenase subunit D; Validated; Region: PRK06075 272568006896 NADH dehydrogenase subunit B; Validated; Region: PRK06411 272568006897 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 272568006898 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 272568006899 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272568006900 putative metal binding site [ion binding]; other site 272568006901 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272568006902 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 272568006903 NAD binding site [chemical binding]; other site 272568006904 substrate binding site [chemical binding]; other site 272568006905 catalytic Zn binding site [ion binding]; other site 272568006906 tetramer interface [polypeptide binding]; other site 272568006907 structural Zn binding site [ion binding]; other site 272568006908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568006909 DNA-binding site [nucleotide binding]; DNA binding site 272568006910 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 272568006911 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272568006912 Phosphoesterase family; Region: Phosphoesterase; pfam04185 272568006913 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 272568006914 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 272568006915 Phosphoesterase family; Region: Phosphoesterase; pfam04185 272568006916 Phosphoesterase family; Region: Phosphoesterase; pfam04185 272568006917 Domain of unknown function (DUF756); Region: DUF756; pfam05506 272568006918 Domain of unknown function (DUF756); Region: DUF756; pfam05506 272568006919 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 272568006920 homotrimer interaction site [polypeptide binding]; other site 272568006921 putative active site [active] 272568006922 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272568006923 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272568006924 homodimer interface [polypeptide binding]; other site 272568006925 substrate-cofactor binding pocket; other site 272568006926 catalytic residue [active] 272568006927 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272568006928 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272568006929 tetramerization interface [polypeptide binding]; other site 272568006930 NAD(P) binding site [chemical binding]; other site 272568006931 catalytic residues [active] 272568006932 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 272568006933 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 272568006934 NADP binding site [chemical binding]; other site 272568006935 dimer interface [polypeptide binding]; other site 272568006936 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272568006937 active site 272568006938 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272568006939 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568006940 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 272568006941 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 272568006942 putative ADP-binding pocket [chemical binding]; other site 272568006943 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 272568006944 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272568006945 SLBB domain; Region: SLBB; pfam10531 272568006946 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 272568006947 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 272568006948 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272568006949 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272568006950 Chain length determinant protein; Region: Wzz; cl15801 272568006951 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272568006952 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272568006953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568006954 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568006955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568006956 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272568006957 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272568006958 active site 272568006959 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272568006960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272568006961 active site 272568006962 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272568006963 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 272568006964 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272568006965 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272568006966 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272568006967 catalytic triad [active] 272568006968 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272568006969 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272568006970 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 272568006971 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272568006972 tetramer interface [polypeptide binding]; other site 272568006973 TPP-binding site [chemical binding]; other site 272568006974 heterodimer interface [polypeptide binding]; other site 272568006975 phosphorylation loop region [posttranslational modification] 272568006976 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272568006977 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272568006978 alpha subunit interface [polypeptide binding]; other site 272568006979 TPP binding site [chemical binding]; other site 272568006980 heterodimer interface [polypeptide binding]; other site 272568006981 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272568006982 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272568006983 E3 interaction surface; other site 272568006984 lipoyl attachment site [posttranslational modification]; other site 272568006985 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 272568006986 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 272568006987 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 272568006988 hypothetical protein; Validated; Region: PRK08238 272568006989 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272568006990 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 272568006991 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 272568006992 Na binding site [ion binding]; other site 272568006993 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 272568006994 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272568006995 active site 272568006996 ADP-ribose binding site [chemical binding]; other site 272568006997 dimer interface [polypeptide binding]; other site 272568006998 nudix motif; other site 272568006999 metal binding site [ion binding]; metal-binding site 272568007000 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 272568007001 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568007002 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 272568007003 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272568007004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007005 NAD(P) binding site [chemical binding]; other site 272568007006 active site 272568007007 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 272568007008 Amidinotransferase; Region: Amidinotransf; pfam02274 272568007009 metabolite-proton symporter; Region: 2A0106; TIGR00883 272568007010 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 272568007011 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568007012 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 272568007013 active site 272568007014 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 272568007015 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272568007016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568007017 putative substrate translocation pore; other site 272568007018 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568007019 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 272568007020 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272568007021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272568007022 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272568007023 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 272568007024 putative NAD(P) binding site [chemical binding]; other site 272568007025 putative substrate binding site [chemical binding]; other site 272568007026 catalytic Zn binding site [ion binding]; other site 272568007027 structural Zn binding site [ion binding]; other site 272568007028 dimer interface [polypeptide binding]; other site 272568007029 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 272568007030 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 272568007031 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568007032 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568007033 TM-ABC transporter signature motif; other site 272568007034 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 272568007035 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272568007036 Walker A/P-loop; other site 272568007037 ATP binding site [chemical binding]; other site 272568007038 Q-loop/lid; other site 272568007039 ABC transporter signature motif; other site 272568007040 Walker B; other site 272568007041 D-loop; other site 272568007042 H-loop/switch region; other site 272568007043 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272568007044 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 272568007045 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 272568007046 putative ligand binding site [chemical binding]; other site 272568007047 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 272568007048 colanic acid exporter; Provisional; Region: PRK10459 272568007049 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272568007050 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272568007051 active site 272568007052 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272568007053 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272568007054 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 272568007055 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 272568007056 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 272568007057 putative ADP-binding pocket [chemical binding]; other site 272568007058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568007059 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272568007060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272568007061 active site 272568007062 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 272568007063 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272568007064 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272568007065 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272568007066 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 272568007067 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272568007068 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 272568007069 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 272568007070 Chain length determinant protein; Region: Wzz; pfam02706 272568007071 AAA domain; Region: AAA_31; pfam13614 272568007072 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272568007073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568007074 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272568007075 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 272568007076 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272568007077 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 272568007078 SLBB domain; Region: SLBB; pfam10531 272568007079 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 272568007080 Alpha 1,4-glycosyltransferase conserved region; Region: Gb3_synth; pfam04572 272568007081 General stress protein [General function prediction only]; Region: GsiB; COG3729 272568007082 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272568007083 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272568007084 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 272568007085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272568007086 active site 272568007087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568007088 S-adenosylmethionine binding site [chemical binding]; other site 272568007089 H+ Antiporter protein; Region: 2A0121; TIGR00900 272568007090 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568007091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568007092 metal binding site [ion binding]; metal-binding site 272568007093 active site 272568007094 I-site; other site 272568007095 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568007096 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 272568007097 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 272568007098 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 272568007099 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568007100 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568007101 metal binding site [ion binding]; metal-binding site 272568007102 active site 272568007103 I-site; other site 272568007104 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568007105 PRC-barrel domain; Region: PRC; pfam05239 272568007106 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272568007107 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 272568007108 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 272568007109 THF binding site; other site 272568007110 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272568007111 substrate binding site [chemical binding]; other site 272568007112 THF binding site; other site 272568007113 zinc-binding site [ion binding]; other site 272568007114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568007115 dimerization interface [polypeptide binding]; other site 272568007116 putative DNA binding site [nucleotide binding]; other site 272568007117 putative Zn2+ binding site [ion binding]; other site 272568007118 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272568007119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568007120 S-adenosylmethionine binding site [chemical binding]; other site 272568007121 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272568007122 FAD binding site [chemical binding]; other site 272568007123 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 272568007124 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272568007125 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272568007126 DNA binding site [nucleotide binding] 272568007127 domain linker motif; other site 272568007128 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 272568007129 putative dimerization interface [polypeptide binding]; other site 272568007130 putative ligand binding site [chemical binding]; other site 272568007131 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568007132 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272568007133 active site 272568007134 putative cation:proton antiport protein; Provisional; Region: PRK10669 272568007135 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272568007136 TrkA-N domain; Region: TrkA_N; pfam02254 272568007137 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 272568007138 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 272568007139 active site 272568007140 Zn binding site [ion binding]; other site 272568007141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007142 short chain dehydrogenase; Validated; Region: PRK07069 272568007143 NAD(P) binding site [chemical binding]; other site 272568007144 active site 272568007146 Winged helix-turn helix; Region: HTH_29; pfam13551 272568007147 Integrase core domain; Region: rve; pfam00665 272568007148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568007149 Integrase core domain; Region: rve_3; pfam13683 272568007150 Winged helix-turn helix; Region: HTH_29; pfam13551 272568007151 Winged helix-turn helix; Region: HTH_33; pfam13592 272568007152 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272568007153 IHF dimer interface [polypeptide binding]; other site 272568007154 IHF - DNA interface [nucleotide binding]; other site 272568007155 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272568007156 GAF domain; Region: GAF_2; pfam13185 272568007157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568007158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568007159 metal binding site [ion binding]; metal-binding site 272568007160 active site 272568007161 I-site; other site 272568007162 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272568007163 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272568007164 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272568007165 Cytochrome P450; Region: p450; cl12078 272568007166 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272568007167 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 272568007168 Subunit I/III interface [polypeptide binding]; other site 272568007169 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 272568007170 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272568007171 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 272568007172 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272568007174 Winged helix-turn helix; Region: HTH_29; pfam13551 272568007175 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568007176 Integrase core domain; Region: rve; pfam00665 272568007177 Integrase core domain; Region: rve_3; pfam13683 272568007178 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 272568007179 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272568007180 ParB-like nuclease domain; Region: ParB; smart00470 272568007181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568007182 salt bridge; other site 272568007183 non-specific DNA binding site [nucleotide binding]; other site 272568007184 sequence-specific DNA binding site [nucleotide binding]; other site 272568007185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568007186 Integrase core domain; Region: rve; pfam00665 272568007187 transposase/IS protein; Provisional; Region: PRK09183 272568007188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568007189 Walker A motif; other site 272568007190 ATP binding site [chemical binding]; other site 272568007191 Walker B motif; other site 272568007192 arginine finger; other site 272568007193 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 272568007194 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 272568007195 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 272568007196 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568007197 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272568007198 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 272568007199 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 272568007200 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272568007201 molybdopterin cofactor binding site; other site 272568007202 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 272568007203 4Fe-4S binding domain; Region: Fer4; cl02805 272568007204 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 272568007205 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 272568007206 heme-binding residues [chemical binding]; other site 272568007207 Cache domain; Region: Cache_1; pfam02743 272568007208 HAMP domain; Region: HAMP; pfam00672 272568007209 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272568007210 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568007211 dimer interface [polypeptide binding]; other site 272568007212 putative CheW interface [polypeptide binding]; other site 272568007213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007214 acetoin reductases; Region: 23BDH; TIGR02415 272568007215 NAD(P) binding site [chemical binding]; other site 272568007216 active site 272568007217 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272568007218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272568007219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007220 NAD(P) binding site [chemical binding]; other site 272568007221 active site 272568007222 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 272568007223 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272568007224 putative ligand binding site [chemical binding]; other site 272568007225 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568007226 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568007227 TM-ABC transporter signature motif; other site 272568007228 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272568007229 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272568007230 Walker A/P-loop; other site 272568007231 ATP binding site [chemical binding]; other site 272568007232 Q-loop/lid; other site 272568007233 ABC transporter signature motif; other site 272568007234 Walker B; other site 272568007235 D-loop; other site 272568007236 H-loop/switch region; other site 272568007237 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272568007238 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 272568007239 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272568007240 putative ligand binding site [chemical binding]; other site 272568007241 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 272568007242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568007243 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568007244 TM-ABC transporter signature motif; other site 272568007245 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 272568007246 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272568007247 Walker A/P-loop; other site 272568007248 ATP binding site [chemical binding]; other site 272568007249 Q-loop/lid; other site 272568007250 ABC transporter signature motif; other site 272568007251 Walker B; other site 272568007252 D-loop; other site 272568007253 H-loop/switch region; other site 272568007254 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 272568007255 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 272568007256 N- and C-terminal domain interface [polypeptide binding]; other site 272568007257 active site 272568007258 MgATP binding site [chemical binding]; other site 272568007259 catalytic site [active] 272568007260 metal binding site [ion binding]; metal-binding site 272568007261 carbohydrate binding site [chemical binding]; other site 272568007262 putative homodimer interface [polypeptide binding]; other site 272568007263 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272568007264 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272568007265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272568007266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568007267 putative PBP binding loops; other site 272568007268 ABC-ATPase subunit interface; other site 272568007269 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272568007270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568007271 dimer interface [polypeptide binding]; other site 272568007272 conserved gate region; other site 272568007273 putative PBP binding loops; other site 272568007274 ABC-ATPase subunit interface; other site 272568007275 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272568007276 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272568007277 Walker A/P-loop; other site 272568007278 ATP binding site [chemical binding]; other site 272568007279 Q-loop/lid; other site 272568007280 ABC transporter signature motif; other site 272568007281 Walker B; other site 272568007282 D-loop; other site 272568007283 H-loop/switch region; other site 272568007284 TOBE domain; Region: TOBE_2; pfam08402 272568007285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007286 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272568007287 NAD(P) binding site [chemical binding]; other site 272568007288 active site 272568007289 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 272568007290 N- and C-terminal domain interface [polypeptide binding]; other site 272568007291 D-xylulose kinase; Region: XylB; TIGR01312 272568007292 active site 272568007293 MgATP binding site [chemical binding]; other site 272568007294 catalytic site [active] 272568007295 metal binding site [ion binding]; metal-binding site 272568007296 xylulose binding site [chemical binding]; other site 272568007297 homodimer interface [polypeptide binding]; other site 272568007298 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272568007299 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568007300 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568007301 TM-ABC transporter signature motif; other site 272568007302 short chain dehydrogenase; Provisional; Region: PRK07454 272568007303 classical (c) SDRs; Region: SDR_c; cd05233 272568007304 NAD(P) binding site [chemical binding]; other site 272568007305 active site 272568007306 NMT1-like family; Region: NMT1_2; pfam13379 272568007307 NMT1/THI5 like; Region: NMT1; pfam09084 272568007308 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272568007309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568007310 putative PBP binding loops; other site 272568007311 dimer interface [polypeptide binding]; other site 272568007312 ABC-ATPase subunit interface; other site 272568007313 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272568007314 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272568007315 Walker A/P-loop; other site 272568007316 ATP binding site [chemical binding]; other site 272568007317 Q-loop/lid; other site 272568007318 ABC transporter signature motif; other site 272568007319 Walker B; other site 272568007320 D-loop; other site 272568007321 H-loop/switch region; other site 272568007322 serine acetyltransferase; Provisional; Region: cysE; PRK11132 272568007323 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 272568007324 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272568007325 trimer interface [polypeptide binding]; other site 272568007326 active site 272568007327 substrate binding site [chemical binding]; other site 272568007328 CoA binding site [chemical binding]; other site 272568007329 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272568007330 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272568007331 ring oligomerisation interface [polypeptide binding]; other site 272568007332 ATP/Mg binding site [chemical binding]; other site 272568007333 stacking interactions; other site 272568007334 hinge regions; other site 272568007335 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272568007336 oligomerisation interface [polypeptide binding]; other site 272568007337 mobile loop; other site 272568007338 roof hairpin; other site 272568007339 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 272568007340 dimer interface [polypeptide binding]; other site 272568007341 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272568007342 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272568007343 catalytic triad [active] 272568007344 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568007345 Serine hydrolase; Region: Ser_hydrolase; pfam06821 272568007346 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272568007347 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272568007348 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272568007349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568007350 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 272568007351 Walker A/P-loop; other site 272568007352 ATP binding site [chemical binding]; other site 272568007353 Q-loop/lid; other site 272568007354 ABC transporter signature motif; other site 272568007355 Walker B; other site 272568007356 D-loop; other site 272568007357 H-loop/switch region; other site 272568007358 NIL domain; Region: NIL; pfam09383 272568007359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568007360 dimer interface [polypeptide binding]; other site 272568007361 ABC-ATPase subunit interface; other site 272568007362 putative PBP binding loops; other site 272568007363 L-fucose isomerase; Provisional; Region: fucI; PRK10991 272568007364 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 272568007365 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272568007366 trimer interface [polypeptide binding]; other site 272568007367 substrate binding site [chemical binding]; other site 272568007368 Mn binding site [ion binding]; other site 272568007369 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272568007370 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 272568007371 putative ligand binding site [chemical binding]; other site 272568007372 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568007373 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568007374 TM-ABC transporter signature motif; other site 272568007375 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272568007376 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272568007377 Walker A/P-loop; other site 272568007378 ATP binding site [chemical binding]; other site 272568007379 Q-loop/lid; other site 272568007380 ABC transporter signature motif; other site 272568007381 Walker B; other site 272568007382 D-loop; other site 272568007383 H-loop/switch region; other site 272568007384 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272568007385 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 272568007386 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272568007387 DNA binding site [nucleotide binding] 272568007388 domain linker motif; other site 272568007389 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272568007390 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 272568007391 Amidohydrolase; Region: Amidohydro_2; pfam04909 272568007392 active site 272568007393 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 272568007394 short chain dehydrogenase; Provisional; Region: PRK08628 272568007395 classical (c) SDRs; Region: SDR_c; cd05233 272568007396 NAD(P) binding site [chemical binding]; other site 272568007397 active site 272568007398 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272568007399 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 272568007400 putative active site pocket [active] 272568007401 metal binding site [ion binding]; metal-binding site 272568007402 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272568007403 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272568007404 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272568007405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007406 NAD(P) binding site [chemical binding]; other site 272568007407 active site 272568007408 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272568007409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568007410 DNA-binding site [nucleotide binding]; DNA binding site 272568007411 FCD domain; Region: FCD; pfam07729 272568007412 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272568007413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568007414 putative DNA binding site [nucleotide binding]; other site 272568007415 putative Zn2+ binding site [ion binding]; other site 272568007416 AsnC family; Region: AsnC_trans_reg; pfam01037 272568007417 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 272568007418 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 272568007419 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 272568007420 Glutamate binding site [chemical binding]; other site 272568007421 NAD binding site [chemical binding]; other site 272568007422 catalytic residues [active] 272568007423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568007424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568007425 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272568007426 putative effector binding pocket; other site 272568007427 putative dimerization interface [polypeptide binding]; other site 272568007428 short chain dehydrogenase; Provisional; Region: PRK12937 272568007429 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 272568007430 NADP binding site [chemical binding]; other site 272568007431 homodimer interface [polypeptide binding]; other site 272568007432 active site 272568007433 substrate binding site [chemical binding]; other site 272568007435 MAPEG family; Region: MAPEG; cl09190 272568007436 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 272568007437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272568007438 ATP binding site [chemical binding]; other site 272568007439 putative Mg++ binding site [ion binding]; other site 272568007440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568007441 nucleotide binding region [chemical binding]; other site 272568007442 ATP-binding site [chemical binding]; other site 272568007443 DEAD/H associated; Region: DEAD_assoc; pfam08494 272568007444 classical (c) SDRs; Region: SDR_c; cd05233 272568007445 NAD(P) binding site [chemical binding]; other site 272568007446 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272568007447 active site 272568007448 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272568007449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007450 NAD(P) binding site [chemical binding]; other site 272568007451 active site 272568007452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007453 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272568007454 NAD(P) binding site [chemical binding]; other site 272568007455 active site 272568007456 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272568007457 iron-sulfur cluster [ion binding]; other site 272568007458 [2Fe-2S] cluster binding site [ion binding]; other site 272568007459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272568007460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568007461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568007462 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 272568007463 Ferritin-like domain; Region: Ferritin; pfam00210 272568007464 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272568007465 dinuclear metal binding motif [ion binding]; other site 272568007466 Winged helix-turn helix; Region: HTH_29; pfam13551 272568007467 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568007468 Integrase core domain; Region: rve; pfam00665 272568007469 Integrase core domain; Region: rve_3; pfam13683 272568007470 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272568007471 MULE transposase domain; Region: MULE; pfam10551 272568007472 Protein of unknown function DUF72; Region: DUF72; pfam01904 272568007473 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272568007474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568007475 DNA-binding site [nucleotide binding]; DNA binding site 272568007476 UTRA domain; Region: UTRA; pfam07702 272568007477 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 272568007478 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272568007479 ligand binding site [chemical binding]; other site 272568007480 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272568007481 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272568007482 Walker A/P-loop; other site 272568007483 ATP binding site [chemical binding]; other site 272568007484 Q-loop/lid; other site 272568007485 ABC transporter signature motif; other site 272568007486 Walker B; other site 272568007487 D-loop; other site 272568007488 H-loop/switch region; other site 272568007489 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272568007490 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272568007491 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568007492 TM-ABC transporter signature motif; other site 272568007493 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272568007494 TM-ABC transporter signature motif; other site 272568007495 Isochorismatase family; Region: Isochorismatase; pfam00857 272568007496 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272568007497 catalytic triad [active] 272568007498 conserved cis-peptide bond; other site 272568007499 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 272568007500 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272568007501 substrate binding site [chemical binding]; other site 272568007502 ATP binding site [chemical binding]; other site 272568007503 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272568007504 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272568007505 hypothetical protein; Provisional; Region: PRK02947 272568007506 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272568007507 putative active site [active] 272568007508 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272568007509 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272568007510 tetramerization interface [polypeptide binding]; other site 272568007511 NAD(P) binding site [chemical binding]; other site 272568007512 catalytic residues [active] 272568007513 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568007514 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568007515 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272568007516 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568007517 catalytic residue [active] 272568007518 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568007519 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568007520 N-terminal plug; other site 272568007521 ligand-binding site [chemical binding]; other site 272568007522 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 272568007523 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 272568007524 putative metal binding site [ion binding]; other site 272568007525 transposase/IS protein; Provisional; Region: PRK09183 272568007526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568007527 Walker A motif; other site 272568007528 ATP binding site [chemical binding]; other site 272568007529 Walker B motif; other site 272568007530 arginine finger; other site 272568007531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568007532 Integrase core domain; Region: rve; pfam00665 272568007534 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272568007535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568007536 Walker A/P-loop; other site 272568007537 ATP binding site [chemical binding]; other site 272568007538 Q-loop/lid; other site 272568007539 ABC transporter signature motif; other site 272568007540 Walker B; other site 272568007541 D-loop; other site 272568007542 H-loop/switch region; other site 272568007543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568007544 putative PBP binding loops; other site 272568007545 dimer interface [polypeptide binding]; other site 272568007546 ABC-ATPase subunit interface; other site 272568007547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272568007548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568007549 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568007550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568007551 dimer interface [polypeptide binding]; other site 272568007552 conserved gate region; other site 272568007553 putative PBP binding loops; other site 272568007554 ABC-ATPase subunit interface; other site 272568007555 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272568007556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272568007557 substrate binding pocket [chemical binding]; other site 272568007558 membrane-bound complex binding site; other site 272568007559 hinge residues; other site 272568007560 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 272568007561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272568007562 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272568007563 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272568007564 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272568007565 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 272568007566 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 272568007567 inhibitor site; inhibition site 272568007568 active site 272568007569 dimer interface [polypeptide binding]; other site 272568007570 catalytic residue [active] 272568007571 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272568007572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568007573 DNA-binding site [nucleotide binding]; DNA binding site 272568007574 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272568007575 phenylhydantoinase; Validated; Region: PRK08323 272568007576 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 272568007577 tetramer interface [polypeptide binding]; other site 272568007578 active site 272568007579 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568007580 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568007581 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568007582 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568007583 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568007584 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568007585 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568007586 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 272568007587 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 272568007589 Transposase; Region: HTH_Tnp_1; pfam01527 272568007590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568007591 short chain dehydrogenase; Provisional; Region: PRK07041 272568007592 NAD(P) binding site [chemical binding]; other site 272568007593 active site 272568007594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568007595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568007596 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568007597 putative effector binding pocket; other site 272568007598 dimerization interface [polypeptide binding]; other site 272568007599 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272568007600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568007601 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272568007602 dimerization interface [polypeptide binding]; other site 272568007603 substrate binding pocket [chemical binding]; other site 272568007604 short chain dehydrogenase; Provisional; Region: PRK08339 272568007605 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 272568007606 putative NAD(P) binding site [chemical binding]; other site 272568007607 putative active site [active] 272568007608 hypothetical protein; Validated; Region: PRK07586 272568007609 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272568007610 PYR/PP interface [polypeptide binding]; other site 272568007611 dimer interface [polypeptide binding]; other site 272568007612 TPP binding site [chemical binding]; other site 272568007613 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 272568007614 TPP-binding site [chemical binding]; other site 272568007615 dimer interface [polypeptide binding]; other site 272568007616 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 272568007617 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 272568007618 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272568007619 potential catalytic triad [active] 272568007620 conserved cys residue [active] 272568007621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568007622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568007623 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272568007624 dimerization interface [polypeptide binding]; other site 272568007625 substrate binding pocket [chemical binding]; other site 272568007626 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 272568007627 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272568007628 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 272568007629 VirB7 interaction site; other site 272568007630 conjugal transfer protein TrbF; Provisional; Region: PRK13872 272568007632 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 272568007633 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 272568007634 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 272568007635 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 272568007636 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 272568007637 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 272568007638 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 272568007639 ATP binding site [chemical binding]; other site 272568007640 Walker A motif; other site 272568007641 hexamer interface [polypeptide binding]; other site 272568007642 Walker B motif; other site 272568007643 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 272568007644 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272568007645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272568007646 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568007647 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568007648 active site 272568007649 catalytic tetrad [active] 272568007650 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 272568007651 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272568007652 Walker A motif; other site 272568007653 ATP binding site [chemical binding]; other site 272568007654 Walker B motif; other site 272568007655 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272568007656 putative active site pocket [active] 272568007657 dimerization interface [polypeptide binding]; other site 272568007658 putative catalytic residue [active] 272568007659 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 272568007660 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 272568007662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 272568007663 Homeodomain-like domain; Region: HTH_23; cl17451 272568007664 Homeodomain-like domain; Region: HTH_32; pfam13565 272568007665 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568007666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568007667 Winged helix-turn helix; Region: HTH_29; pfam13551 272568007668 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568007669 Integrase core domain; Region: rve; pfam00665 272568007670 Integrase core domain; Region: rve_3; pfam13683 272568007671 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 272568007672 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 272568007673 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272568007674 Moco binding site; other site 272568007675 metal coordination site [ion binding]; other site 272568007676 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 272568007677 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 272568007678 SelR domain; Region: SelR; pfam01641 272568007679 methionine sulfoxide reductase A; Provisional; Region: PRK13014 272568007680 RNA polymerase sigma factor; Provisional; Region: PRK12512 272568007681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272568007682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272568007683 DNA binding residues [nucleotide binding] 272568007684 putative S-transferase; Provisional; Region: PRK11752 272568007685 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272568007686 C-terminal domain interface [polypeptide binding]; other site 272568007687 GSH binding site (G-site) [chemical binding]; other site 272568007688 dimer interface [polypeptide binding]; other site 272568007689 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 272568007690 dimer interface [polypeptide binding]; other site 272568007691 N-terminal domain interface [polypeptide binding]; other site 272568007692 active site 272568007693 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568007694 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272568007695 C-terminal domain interface [polypeptide binding]; other site 272568007696 GSH binding site (G-site) [chemical binding]; other site 272568007697 dimer interface [polypeptide binding]; other site 272568007698 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272568007699 N-terminal domain interface [polypeptide binding]; other site 272568007700 dimer interface [polypeptide binding]; other site 272568007701 substrate binding pocket (H-site) [chemical binding]; other site 272568007702 classical (c) SDRs; Region: SDR_c; cd05233 272568007703 NAD(P) binding site [chemical binding]; other site 272568007704 active site 272568007705 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 272568007706 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 272568007707 putative catalytic residues [active] 272568007708 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272568007709 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 272568007710 FMN binding site [chemical binding]; other site 272568007711 active site 272568007712 substrate binding site [chemical binding]; other site 272568007713 catalytic residue [active] 272568007714 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568007715 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272568007716 C-terminal domain interface [polypeptide binding]; other site 272568007717 GSH binding site (G-site) [chemical binding]; other site 272568007718 dimer interface [polypeptide binding]; other site 272568007719 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 272568007720 dimer interface [polypeptide binding]; other site 272568007721 N-terminal domain interface [polypeptide binding]; other site 272568007722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568007723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568007724 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568007725 putative effector binding pocket; other site 272568007726 dimerization interface [polypeptide binding]; other site 272568007727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568007728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568007729 AhpC/TSA family; Region: AhpC-TSA; pfam00578 272568007730 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272568007731 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272568007732 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272568007733 MULE transposase domain; Region: MULE; pfam10551 272568007734 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272568007735 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272568007736 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272568007737 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272568007738 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272568007739 Cl- selectivity filter; other site 272568007740 Cl- binding residues [ion binding]; other site 272568007741 pore gating glutamate residue; other site 272568007742 dimer interface [polypeptide binding]; other site 272568007743 H+/Cl- coupling transport residue; other site 272568007744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568007745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568007746 oxidoreductase; Provisional; Region: PRK06196 272568007747 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 272568007748 putative NAD(P) binding site [chemical binding]; other site 272568007749 active site 272568007750 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272568007751 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272568007752 putative active site [active] 272568007753 putative metal binding site [ion binding]; other site 272568007754 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 272568007755 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272568007756 short chain dehydrogenase; Provisional; Region: PRK06500 272568007757 classical (c) SDRs; Region: SDR_c; cd05233 272568007758 NAD(P) binding site [chemical binding]; other site 272568007759 active site 272568007760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568007761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568007762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568007763 dimerization interface [polypeptide binding]; other site 272568007764 Toprim domain; Region: Toprim_3; pfam13362 272568007767 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568007768 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568007769 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568007770 catalytic residue [active] 272568007771 Protein of unknown function (DUF736); Region: DUF736; pfam05284 272568007772 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 272568007773 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 272568007774 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 272568007775 Replication initiator protein A; Region: RPA; pfam10134 272568007776 Helix-turn-helix domain; Region: HTH_17; pfam12728 272568007777 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 272568007778 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272568007779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568007780 non-specific DNA binding site [nucleotide binding]; other site 272568007781 salt bridge; other site 272568007782 sequence-specific DNA binding site [nucleotide binding]; other site 272568007783 Protein of unknown function (DUF736); Region: DUF736; pfam05284 272568007784 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 272568007785 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 272568007786 Toprim domain; Region: Toprim_3; pfam13362 272568007787 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272568007788 IHF - DNA interface [nucleotide binding]; other site 272568007789 IHF dimer interface [polypeptide binding]; other site 272568007790 ParB-like nuclease domain; Region: ParB; smart00470 272568007791 AAA domain; Region: AAA_21; pfam13304 272568007792 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272568007793 AAA domain; Region: AAA_30; pfam13604 272568007794 Family description; Region: UvrD_C_2; pfam13538 272568007795 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272568007796 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272568007797 catalytic residues [active] 272568007798 catalytic nucleophile [active] 272568007799 Recombinase; Region: Recombinase; pfam07508 272568007800 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272568007801 DDE superfamily endonuclease; Region: DDE_5; cl17874 272568007802 Winged helix-turn helix; Region: HTH_29; pfam13551 272568007803 Helix-turn-helix domain; Region: HTH_28; pfam13518 272568007804 Integrase core domain; Region: rve; pfam00665 272568007805 Integrase core domain; Region: rve_3; pfam13683 272568007806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 272568007807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568007808 ABC transporter signature motif; other site 272568007809 Walker B; other site 272568007810 D-loop; other site 272568007811 H-loop/switch region; other site 272568007812 Transposase; Region: HTH_Tnp_1; cl17663 272568007814 LabA_like proteins; Region: LabA_like; cd06167 272568007815 putative metal binding site [ion binding]; other site 272568007816 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272568007817 Condensation domain; Region: Condensation; pfam00668 272568007818 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272568007819 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272568007820 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272568007821 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272568007822 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 272568007823 acyl-activating enzyme (AAE) consensus motif; other site 272568007824 AMP binding site [chemical binding]; other site 272568007825 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272568007826 Condensation domain; Region: Condensation; pfam00668 272568007827 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272568007828 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272568007829 acyl-activating enzyme (AAE) consensus motif; other site 272568007830 AMP binding site [chemical binding]; other site 272568007831 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 272568007832 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272568007833 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272568007834 acyl-activating enzyme (AAE) consensus motif; other site 272568007835 AMP binding site [chemical binding]; other site 272568007836 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272568007837 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 272568007838 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 272568007839 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272568007840 acyl-activating enzyme (AAE) consensus motif; other site 272568007841 AMP binding site [chemical binding]; other site 272568007842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272568007843 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 272568007844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568007845 H+ Antiporter protein; Region: 2A0121; TIGR00900 272568007846 putative substrate translocation pore; other site 272568007847 Autoinducer synthetase; Region: Autoind_synth; cl17404 272568007848 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272568007849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272568007850 DNA binding residues [nucleotide binding] 272568007851 dimerization interface [polypeptide binding]; other site 272568007852 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272568007853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272568007854 DNA binding residues [nucleotide binding] 272568007855 dimerization interface [polypeptide binding]; other site 272568007856 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272568007857 DNA-binding interface [nucleotide binding]; DNA binding site 272568007858 putative transposase OrfB; Reviewed; Region: PHA02517 272568007859 HTH-like domain; Region: HTH_21; pfam13276 272568007860 Integrase core domain; Region: rve; pfam00665 272568007861 Integrase core domain; Region: rve_3; pfam13683 272568007862 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568007863 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568007864 active site 272568007865 catalytic tetrad [active] 272568007866 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 272568007867 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272568007868 NAD(P) binding site [chemical binding]; other site 272568007869 active site 272568007870 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 272568007871 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272568007872 potential catalytic triad [active] 272568007873 conserved cys residue [active] 272568007874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568007875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568007876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272568007877 dimerization interface [polypeptide binding]; other site 272568007878 Domain of unknown function (DUF336); Region: DUF336; pfam03928 272568007879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568007880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568007881 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 272568007882 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272568007883 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568007884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568007885 putative substrate translocation pore; other site 272568007886 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568007887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568007888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568007889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272568007890 dimerization interface [polypeptide binding]; other site 272568007891 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568007892 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568007893 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568007894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568007895 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272568007896 dimer interface [polypeptide binding]; other site 272568007897 active site 272568007898 metal binding site [ion binding]; metal-binding site 272568007899 glutathione binding site [chemical binding]; other site 272568007900 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272568007901 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272568007902 conserved cys residue [active] 272568007903 Transposase; Region: HTH_Tnp_1; pfam01527 272568007904 putative transposase OrfB; Reviewed; Region: PHA02517 272568007905 HTH-like domain; Region: HTH_21; pfam13276 272568007906 Integrase core domain; Region: rve; pfam00665 272568007907 Integrase core domain; Region: rve_3; pfam13683 272568007908 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 272568007909 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 272568007910 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 272568007911 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272568007912 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272568007913 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272568007914 catalytic residue [active] 272568007915 Protein of unknown function (DUF736); Region: DUF736; pfam05284 272568007916 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 272568007917 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 272568007918 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 272568007919 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272568007920 DNA methylase; Region: N6_N4_Mtase; pfam01555 272568007921 Replication initiator protein A; Region: RPA; cl17860 272568007922 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 272568007923 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 272568007924 Uncharacterized conserved protein [Function unknown]; Region: COG5489 272568007925 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 272568007926 Toprim domain; Region: Toprim_3; pfam13362 272568007927 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272568007928 IHF - DNA interface [nucleotide binding]; other site 272568007929 IHF dimer interface [polypeptide binding]; other site 272568007930 ParB-like nuclease domain; Region: ParB; smart00470 272568007931 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272568007932 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568007933 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568007934 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 272568007935 putative dimer interface [polypeptide binding]; other site 272568007936 putative N-terminal domain interface [polypeptide binding]; other site 272568007937 putative substrate binding pocket (H-site) [chemical binding]; other site 272568007938 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 272568007939 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 272568007940 putative active site [active] 272568007941 putative PHP Thumb interface [polypeptide binding]; other site 272568007942 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272568007943 generic binding surface I; other site 272568007944 generic binding surface II; other site 272568007945 DNA Polymerase Y-family; Region: PolY_like; cd03468 272568007946 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272568007947 DNA binding site [nucleotide binding] 272568007948 Uncharacterized conserved protein [Function unknown]; Region: COG4544 272568007949 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272568007950 Part of AAA domain; Region: AAA_19; pfam13245 272568007951 Family description; Region: UvrD_C_2; pfam13538 272568007952 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 272568007953 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 272568007954 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 272568007955 ATP binding site [chemical binding]; other site 272568007956 substrate interface [chemical binding]; other site 272568007957 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 272568007958 metal binding triad [ion binding]; metal-binding site 272568007959 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 272568007960 active site 272568007961 nucleophile elbow; other site 272568007962 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 272568007963 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272568007964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568007965 non-specific DNA binding site [nucleotide binding]; other site 272568007966 salt bridge; other site 272568007967 sequence-specific DNA binding site [nucleotide binding]; other site 272568007968 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272568007969 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272568007970 active site 272568007971 substrate binding site [chemical binding]; other site 272568007972 catalytic site [active] 272568007973 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 272568007974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568007975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568007976 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 272568007977 Winged helix-turn helix; Region: HTH_29; pfam13551 272568007978 Winged helix-turn helix; Region: HTH_33; pfam13592 272568007980 Winged helix-turn helix; Region: HTH_29; pfam13551 272568007981 Integrase core domain; Region: rve; pfam00665 272568007982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568007983 Integrase core domain; Region: rve_3; pfam13683 272568007984 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 272568007985 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272568007986 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 272568007987 VirB7 interaction site; other site 272568007988 conjugal transfer protein TrbF; Provisional; Region: PRK13872 272568007989 conjugal transfer protein TrbL; Provisional; Region: PRK13875 272568007990 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 272568007991 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 272568007992 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 272568007993 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 272568007994 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 272568007995 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 272568007996 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 272568007997 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 272568007998 ATP binding site [chemical binding]; other site 272568007999 Walker A motif; other site 272568008000 hexamer interface [polypeptide binding]; other site 272568008001 Walker B motif; other site 272568008002 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272568008003 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 272568008004 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272568008005 Walker A motif; other site 272568008006 ATP binding site [chemical binding]; other site 272568008007 Walker B motif; other site 272568008008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568008009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568008010 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272568008011 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272568008012 catalytic residues [active] 272568008013 catalytic nucleophile [active] 272568008014 Recombinase; Region: Recombinase; pfam07508 272568008015 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272568008016 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272568008017 acyl-CoA synthetase; Validated; Region: PRK09192 272568008018 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272568008019 acyl-activating enzyme (AAE) consensus motif; other site 272568008020 active site 272568008021 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272568008022 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272568008023 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272568008024 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568008025 catalytic residue [active] 272568008026 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272568008027 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272568008028 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272568008029 active site 272568008030 metal binding site [ion binding]; metal-binding site 272568008031 Predicted permeases [General function prediction only]; Region: COG0795 272568008032 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272568008033 Predicted permeases [General function prediction only]; Region: COG0795 272568008034 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272568008035 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 272568008036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272568008037 active site 272568008038 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568008039 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 272568008040 putative ADP-binding pocket [chemical binding]; other site 272568008041 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 272568008042 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272568008043 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 272568008044 active site 272568008045 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 272568008046 putative amphipathic alpha helix; other site 272568008047 YceG-like family; Region: YceG; pfam02618 272568008048 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272568008049 dimerization interface [polypeptide binding]; other site 272568008050 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 272568008051 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272568008052 dimer interface [polypeptide binding]; other site 272568008053 active site 272568008054 acyl carrier protein; Provisional; Region: acpP; PRK00982 272568008055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568008056 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 272568008057 NAD(P) binding site [chemical binding]; other site 272568008058 active site 272568008059 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272568008060 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272568008061 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272568008062 putative active site [active] 272568008063 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272568008064 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 272568008065 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272568008066 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272568008067 active site 272568008068 Zn binding site [ion binding]; other site 272568008069 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 272568008070 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272568008071 dinuclear metal binding motif [ion binding]; other site 272568008072 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 272568008073 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272568008074 CoA-ligase; Region: Ligase_CoA; pfam00549 272568008075 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272568008076 CoA binding domain; Region: CoA_binding; pfam02629 272568008077 CoA-ligase; Region: Ligase_CoA; pfam00549 272568008078 biotin synthase; Region: bioB; TIGR00433 272568008079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568008080 FeS/SAM binding site; other site 272568008081 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 272568008082 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 272568008083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568008084 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 272568008085 Ligand Binding Site [chemical binding]; other site 272568008086 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 272568008087 active site 272568008088 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272568008089 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272568008090 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272568008091 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272568008092 mce related protein; Region: MCE; pfam02470 272568008093 Permease; Region: Permease; pfam02405 272568008094 Cache domain; Region: Cache_1; pfam02743 272568008095 cyclase homology domain; Region: CHD; cd07302 272568008096 nucleotidyl binding site; other site 272568008097 metal binding site [ion binding]; metal-binding site 272568008098 dimer interface [polypeptide binding]; other site 272568008099 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 272568008100 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 272568008101 active site 272568008102 catalytic site [active] 272568008103 substrate binding site [chemical binding]; other site 272568008104 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272568008105 dephospho-CoA kinase; Region: TIGR00152 272568008106 CoA-binding site [chemical binding]; other site 272568008107 ATP-binding [chemical binding]; other site 272568008108 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272568008109 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272568008110 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272568008111 shikimate binding site; other site 272568008112 NAD(P) binding site [chemical binding]; other site 272568008113 N-formylglutamate amidohydrolase; Region: FGase; cl01522 272568008114 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272568008115 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272568008116 catalytic residues [active] 272568008117 argininosuccinate lyase; Provisional; Region: PRK00855 272568008118 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272568008119 active sites [active] 272568008120 tetramer interface [polypeptide binding]; other site 272568008121 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272568008122 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 272568008123 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272568008124 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272568008125 active site 272568008126 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272568008127 substrate binding site [chemical binding]; other site 272568008128 catalytic residues [active] 272568008129 dimer interface [polypeptide binding]; other site 272568008130 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272568008131 active site 272568008132 catalytic motif [active] 272568008133 Zn binding site [ion binding]; other site 272568008134 O-Antigen ligase; Region: Wzy_C; pfam04932 272568008135 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272568008136 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272568008137 GatB domain; Region: GatB_Yqey; smart00845 272568008138 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272568008139 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272568008140 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272568008141 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 272568008142 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 272568008143 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 272568008145 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568008146 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272568008147 NAD(P) binding pocket [chemical binding]; other site 272568008148 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 272568008149 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568008150 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568008151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568008152 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272568008153 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272568008154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272568008155 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272568008156 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568008157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272568008158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272568008159 binding surface 272568008160 TPR motif; other site 272568008161 TPR repeat; Region: TPR_11; pfam13414 272568008162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272568008163 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272568008164 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 272568008165 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 272568008166 helicase 45; Provisional; Region: PTZ00424 272568008167 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272568008168 ATP binding site [chemical binding]; other site 272568008169 Mg++ binding site [ion binding]; other site 272568008170 motif III; other site 272568008171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568008172 nucleotide binding region [chemical binding]; other site 272568008173 ATP-binding site [chemical binding]; other site 272568008174 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 272568008175 putative active site [active] 272568008176 Zn binding site [ion binding]; other site 272568008177 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 272568008178 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 272568008179 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272568008180 NAD(P) binding site [chemical binding]; other site 272568008181 catalytic residues [active] 272568008182 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272568008183 classical (c) SDRs; Region: SDR_c; cd05233 272568008184 NAD(P) binding site [chemical binding]; other site 272568008185 active site 272568008186 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 272568008187 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272568008188 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272568008189 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272568008190 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272568008191 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272568008192 acyl-activating enzyme (AAE) consensus motif; other site 272568008193 acyl-activating enzyme (AAE) consensus motif; other site 272568008194 AMP binding site [chemical binding]; other site 272568008195 active site 272568008196 CoA binding site [chemical binding]; other site 272568008197 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272568008198 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 272568008199 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 272568008200 putative trimer interface [polypeptide binding]; other site 272568008201 putative CoA binding site [chemical binding]; other site 272568008202 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 272568008203 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272568008204 PYR/PP interface [polypeptide binding]; other site 272568008205 dimer interface [polypeptide binding]; other site 272568008206 TPP binding site [chemical binding]; other site 272568008207 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272568008208 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272568008209 TPP-binding site [chemical binding]; other site 272568008210 dimer interface [polypeptide binding]; other site 272568008211 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272568008212 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272568008213 dimer interface [polypeptide binding]; other site 272568008214 active site 272568008215 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272568008216 folate binding site [chemical binding]; other site 272568008217 amino acid transporter; Region: 2A0306; TIGR00909 272568008218 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272568008219 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 272568008220 dimer interface [polypeptide binding]; other site 272568008221 allosteric magnesium binding site [ion binding]; other site 272568008222 active site 272568008223 aspartate-rich active site metal binding site; other site 272568008224 Schiff base residues; other site 272568008225 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 272568008226 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 272568008227 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 272568008228 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272568008229 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272568008230 CAP-like domain; other site 272568008231 active site 272568008232 primary dimer interface [polypeptide binding]; other site 272568008233 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272568008234 Recombination protein O N terminal; Region: RecO_N; pfam11967 272568008235 Recombination protein O C terminal; Region: RecO_C; pfam02565 272568008236 elongation factor Ts; Provisional; Region: tsf; PRK09377 272568008237 UBA/TS-N domain; Region: UBA; pfam00627 272568008238 Elongation factor TS; Region: EF_TS; pfam00889 272568008239 Elongation factor TS; Region: EF_TS; pfam00889 272568008240 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272568008241 rRNA interaction site [nucleotide binding]; other site 272568008242 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272568008243 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 272568008244 putative active site [active] 272568008245 putative PHP Thumb interface [polypeptide binding]; other site 272568008246 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272568008247 generic binding surface II; other site 272568008248 generic binding surface I; other site 272568008249 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272568008250 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272568008251 Walker A/P-loop; other site 272568008252 ATP binding site [chemical binding]; other site 272568008253 Q-loop/lid; other site 272568008254 ABC transporter signature motif; other site 272568008255 Walker B; other site 272568008256 D-loop; other site 272568008257 H-loop/switch region; other site 272568008258 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 272568008259 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272568008260 FtsX-like permease family; Region: FtsX; pfam02687 272568008261 prolyl-tRNA synthetase; Provisional; Region: PRK12325 272568008262 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272568008263 dimer interface [polypeptide binding]; other site 272568008264 motif 1; other site 272568008265 active site 272568008266 motif 2; other site 272568008267 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272568008268 motif 3; other site 272568008269 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272568008270 anticodon binding site; other site 272568008271 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272568008272 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272568008273 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272568008274 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272568008275 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272568008276 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272568008277 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 272568008278 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272568008279 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 272568008280 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272568008281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272568008282 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 272568008283 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 272568008284 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 272568008285 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 272568008286 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 272568008287 4Fe-4S binding domain; Region: Fer4; cl02805 272568008288 4Fe-4S binding domain; Region: Fer4; pfam00037 272568008289 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 272568008290 NADH dehydrogenase subunit G; Validated; Region: PRK09130 272568008291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272568008292 catalytic loop [active] 272568008293 iron binding site [ion binding]; other site 272568008294 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272568008295 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 272568008296 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 272568008297 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 272568008298 SLBB domain; Region: SLBB; pfam10531 272568008299 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 272568008300 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 272568008301 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272568008302 putative dimer interface [polypeptide binding]; other site 272568008303 [2Fe-2S] cluster binding site [ion binding]; other site 272568008304 NADH dehydrogenase subunit D; Validated; Region: PRK06075 272568008305 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 272568008306 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 272568008307 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 272568008308 NADH dehydrogenase subunit B; Validated; Region: PRK06411 272568008309 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 272568008310 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272568008311 IHF - DNA interface [nucleotide binding]; other site 272568008312 IHF dimer interface [polypeptide binding]; other site 272568008313 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272568008314 Found in ATP-dependent protease La (LON); Region: LON; smart00464 272568008315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568008316 Walker A motif; other site 272568008317 ATP binding site [chemical binding]; other site 272568008318 Walker B motif; other site 272568008319 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272568008320 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272568008321 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272568008322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568008323 Walker A motif; other site 272568008324 ATP binding site [chemical binding]; other site 272568008325 Walker B motif; other site 272568008326 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272568008327 Clp protease; Region: CLP_protease; pfam00574 272568008328 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272568008329 oligomer interface [polypeptide binding]; other site 272568008330 active site residues [active] 272568008331 trigger factor; Provisional; Region: tig; PRK01490 272568008332 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272568008333 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272568008334 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 272568008335 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272568008336 putative ATP binding site [chemical binding]; other site 272568008337 putative substrate binding site [chemical binding]; other site 272568008338 Predicted integral membrane protein [Function unknown]; Region: COG5615 272568008339 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 272568008340 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272568008341 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272568008342 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272568008343 ATP binding site [chemical binding]; other site 272568008344 Mg++ binding site [ion binding]; other site 272568008345 motif III; other site 272568008346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568008347 nucleotide binding region [chemical binding]; other site 272568008348 ATP-binding site [chemical binding]; other site 272568008349 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272568008350 TRAM domain; Region: TRAM; cl01282 272568008351 Predicted methyltransferase [General function prediction only]; Region: COG4798 272568008352 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 272568008353 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 272568008354 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272568008355 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272568008356 trimerization site [polypeptide binding]; other site 272568008357 active site 272568008358 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272568008359 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272568008360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272568008361 catalytic residue [active] 272568008362 FeS assembly protein SufD; Region: sufD; TIGR01981 272568008363 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272568008364 FeS assembly ATPase SufC; Region: sufC; TIGR01978 272568008365 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272568008366 Walker A/P-loop; other site 272568008367 ATP binding site [chemical binding]; other site 272568008368 Q-loop/lid; other site 272568008369 ABC transporter signature motif; other site 272568008370 Walker B; other site 272568008371 D-loop; other site 272568008372 H-loop/switch region; other site 272568008373 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 272568008374 putative ABC transporter; Region: ycf24; CHL00085 272568008375 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 272568008376 Transcriptional regulator; Region: Rrf2; pfam02082 272568008377 Protein of unknown function (DUF445); Region: DUF445; pfam04286 272568008378 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 272568008379 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272568008380 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 272568008381 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 272568008382 elongation factor G; Reviewed; Region: PRK12739 272568008383 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272568008384 G1 box; other site 272568008385 putative GEF interaction site [polypeptide binding]; other site 272568008386 GTP/Mg2+ binding site [chemical binding]; other site 272568008387 Switch I region; other site 272568008388 G2 box; other site 272568008389 G3 box; other site 272568008390 Switch II region; other site 272568008391 G4 box; other site 272568008392 G5 box; other site 272568008393 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272568008394 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272568008395 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272568008396 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272568008397 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272568008398 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272568008399 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 272568008400 Walker A/P-loop; other site 272568008401 ATP binding site [chemical binding]; other site 272568008402 Q-loop/lid; other site 272568008403 ABC transporter signature motif; other site 272568008404 Walker B; other site 272568008405 D-loop; other site 272568008406 H-loop/switch region; other site 272568008407 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272568008408 nudix motif; other site 272568008409 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 272568008410 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 272568008411 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272568008412 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272568008413 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 272568008414 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272568008415 DNA binding residues [nucleotide binding] 272568008416 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272568008417 IHF dimer interface [polypeptide binding]; other site 272568008418 IHF - DNA interface [nucleotide binding]; other site 272568008419 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272568008420 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272568008421 dimer interface [polypeptide binding]; other site 272568008422 active site 272568008423 CoA binding pocket [chemical binding]; other site 272568008424 putative phosphate acyltransferase; Provisional; Region: PRK05331 272568008425 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 272568008426 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 272568008427 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 272568008428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272568008429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568008430 ATP binding site [chemical binding]; other site 272568008431 Mg2+ binding site [ion binding]; other site 272568008432 G-X-G motif; other site 272568008433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568008434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568008435 active site 272568008436 phosphorylation site [posttranslational modification] 272568008437 intermolecular recognition site; other site 272568008438 dimerization interface [polypeptide binding]; other site 272568008439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568008440 DNA binding site [nucleotide binding] 272568008441 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272568008442 MarR family; Region: MarR_2; pfam12802 272568008443 COQ9; Region: COQ9; pfam08511 272568008444 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272568008445 active site 272568008446 catalytic residues [active] 272568008447 metal binding site [ion binding]; metal-binding site 272568008448 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272568008449 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272568008450 tartrate dehydrogenase; Region: TTC; TIGR02089 272568008451 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 272568008452 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272568008453 substrate binding site [chemical binding]; other site 272568008454 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 272568008455 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272568008456 substrate binding site [chemical binding]; other site 272568008457 ligand binding site [chemical binding]; other site 272568008458 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272568008459 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272568008460 RimM N-terminal domain; Region: RimM; pfam01782 272568008461 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 272568008462 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272568008463 signal recognition particle protein; Provisional; Region: PRK10867 272568008464 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272568008465 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272568008466 P loop; other site 272568008467 GTP binding site [chemical binding]; other site 272568008468 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272568008469 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 272568008470 dimer interface [polypeptide binding]; other site 272568008471 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272568008472 PhoU domain; Region: PhoU; pfam01895 272568008473 PhoU domain; Region: PhoU; pfam01895 272568008474 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 272568008475 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272568008476 Walker A/P-loop; other site 272568008477 ATP binding site [chemical binding]; other site 272568008478 Q-loop/lid; other site 272568008479 ABC transporter signature motif; other site 272568008480 Walker B; other site 272568008481 D-loop; other site 272568008482 H-loop/switch region; other site 272568008483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568008484 dimer interface [polypeptide binding]; other site 272568008485 conserved gate region; other site 272568008486 putative PBP binding loops; other site 272568008487 ABC-ATPase subunit interface; other site 272568008488 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 272568008489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568008490 dimer interface [polypeptide binding]; other site 272568008491 conserved gate region; other site 272568008492 putative PBP binding loops; other site 272568008493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272568008494 ABC-ATPase subunit interface; other site 272568008496 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272568008497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568008498 Walker A/P-loop; other site 272568008499 ATP binding site [chemical binding]; other site 272568008500 Q-loop/lid; other site 272568008501 ABC transporter signature motif; other site 272568008502 Walker B; other site 272568008503 D-loop; other site 272568008504 H-loop/switch region; other site 272568008505 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 272568008506 RNA/DNA hybrid binding site [nucleotide binding]; other site 272568008507 active site 272568008508 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 272568008509 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 272568008510 putative active site [active] 272568008511 putative substrate binding site [chemical binding]; other site 272568008512 ATP binding site [chemical binding]; other site 272568008513 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 272568008514 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 272568008515 Predicted membrane protein [Function unknown]; Region: COG1297 272568008516 putative oligopeptide transporter, OPT family; Region: TIGR00733 272568008517 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272568008518 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 272568008519 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272568008520 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 272568008521 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 272568008522 active site 272568008523 Zn binding site [ion binding]; other site 272568008524 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272568008525 catalytic residues [active] 272568008526 Winged helix-turn helix; Region: HTH_29; pfam13551 272568008527 Integrase core domain; Region: rve; pfam00665 272568008528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568008529 Integrase core domain; Region: rve_3; pfam13683 272568008530 FtsJ-like methyltransferase; Region: FtsJ; cl17430 272568008531 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 272568008532 TAP-like protein; Region: Abhydrolase_4; pfam08386 272568008533 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 272568008534 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 272568008535 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 272568008536 AAA domain; Region: AAA_33; pfam13671 272568008537 ATP-binding site [chemical binding]; other site 272568008538 Gluconate-6-phosphate binding site [chemical binding]; other site 272568008539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568008540 putative substrate translocation pore; other site 272568008541 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 272568008542 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 272568008543 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272568008544 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272568008545 Walker A/P-loop; other site 272568008546 ATP binding site [chemical binding]; other site 272568008547 Q-loop/lid; other site 272568008548 ABC transporter signature motif; other site 272568008549 Walker B; other site 272568008550 D-loop; other site 272568008551 H-loop/switch region; other site 272568008552 aspartate aminotransferase; Provisional; Region: PRK05764 272568008553 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568008554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568008555 homodimer interface [polypeptide binding]; other site 272568008556 catalytic residue [active] 272568008557 aspartate aminotransferase; Provisional; Region: PRK05764 272568008558 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568008559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568008560 homodimer interface [polypeptide binding]; other site 272568008561 catalytic residue [active] 272568008562 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 272568008563 active site 272568008564 HIGH motif; other site 272568008565 nucleotide binding site [chemical binding]; other site 272568008566 active site 272568008567 KMSKS motif; other site 272568008568 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272568008569 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272568008570 active site 272568008571 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 272568008572 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 272568008573 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 272568008574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272568008575 FeS/SAM binding site; other site 272568008576 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272568008577 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272568008578 metal-binding site [ion binding] 272568008579 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272568008580 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272568008581 metal-binding site [ion binding] 272568008582 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272568008583 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272568008584 metal-binding site [ion binding] 272568008585 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 272568008586 ArsC family; Region: ArsC; pfam03960 272568008587 putative catalytic residues [active] 272568008588 phosphoglucomutase; Validated; Region: PRK07564 272568008589 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 272568008590 active site 272568008591 substrate binding site [chemical binding]; other site 272568008592 metal binding site [ion binding]; metal-binding site 272568008593 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 272568008594 catalytic nucleophile [active] 272568008595 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272568008596 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 272568008597 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272568008598 active site 272568008599 substrate binding site [chemical binding]; other site 272568008600 metal binding site [ion binding]; metal-binding site 272568008601 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272568008602 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 272568008603 inhibitor binding site; inhibition site 272568008604 catalytic Zn binding site [ion binding]; other site 272568008605 structural Zn binding site [ion binding]; other site 272568008606 NADP binding site [chemical binding]; other site 272568008607 tetramer interface [polypeptide binding]; other site 272568008608 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272568008609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272568008610 Integrase core domain; Region: rve; pfam00665 272568008611 transposase/IS protein; Provisional; Region: PRK09183 272568008612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568008613 Walker A motif; other site 272568008614 ATP binding site [chemical binding]; other site 272568008615 Walker B motif; other site 272568008616 arginine finger; other site 272568008617 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 272568008618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272568008619 GMP synthase; Reviewed; Region: guaA; PRK00074 272568008620 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272568008621 AMP/PPi binding site [chemical binding]; other site 272568008622 candidate oxyanion hole; other site 272568008623 catalytic triad [active] 272568008624 potential glutamine specificity residues [chemical binding]; other site 272568008625 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272568008626 ATP Binding subdomain [chemical binding]; other site 272568008627 Ligand Binding sites [chemical binding]; other site 272568008628 Dimerization subdomain; other site 272568008629 Predicted acyl esterases [General function prediction only]; Region: COG2936 272568008630 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272568008631 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 272568008632 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 272568008633 nudix motif; other site 272568008634 Response regulator receiver domain; Region: Response_reg; pfam00072 272568008635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568008636 active site 272568008637 phosphorylation site [posttranslational modification] 272568008638 intermolecular recognition site; other site 272568008639 dimerization interface [polypeptide binding]; other site 272568008640 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 272568008641 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 272568008642 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 272568008643 Ligand binding site; other site 272568008644 Putative Catalytic site; other site 272568008645 DXD motif; other site 272568008646 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272568008647 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 272568008648 AsnC family; Region: AsnC_trans_reg; pfam01037 272568008649 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272568008650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568008651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272568008652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568008653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568008654 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568008655 putative effector binding pocket; other site 272568008656 dimerization interface [polypeptide binding]; other site 272568008657 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272568008658 IHF dimer interface [polypeptide binding]; other site 272568008659 IHF - DNA interface [nucleotide binding]; other site 272568008660 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272568008661 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 272568008662 tandem repeat interface [polypeptide binding]; other site 272568008663 oligomer interface [polypeptide binding]; other site 272568008664 active site residues [active] 272568008665 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 272568008666 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272568008667 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272568008668 substrate binding site [chemical binding]; other site 272568008669 dimer interface [polypeptide binding]; other site 272568008670 ATP binding site [chemical binding]; other site 272568008671 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272568008672 C-terminal domain interface [polypeptide binding]; other site 272568008673 GSH binding site (G-site) [chemical binding]; other site 272568008674 dimer interface [polypeptide binding]; other site 272568008675 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272568008676 N-terminal domain interface [polypeptide binding]; other site 272568008677 dimer interface [polypeptide binding]; other site 272568008678 substrate binding pocket (H-site) [chemical binding]; other site 272568008679 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 272568008680 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272568008681 Fe-S cluster binding site [ion binding]; other site 272568008682 active site 272568008683 Fusaric acid resistance protein family; Region: FUSC; pfam04632 272568008684 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272568008685 guanine deaminase; Provisional; Region: PRK09228 272568008686 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 272568008687 active site 272568008688 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568008689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568008690 metal binding site [ion binding]; metal-binding site 272568008691 active site 272568008692 I-site; other site 272568008693 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568008694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568008695 active site 272568008696 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 272568008697 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272568008698 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272568008699 GTPase CgtA; Reviewed; Region: obgE; PRK12299 272568008700 GTP1/OBG; Region: GTP1_OBG; pfam01018 272568008701 Obg GTPase; Region: Obg; cd01898 272568008702 G1 box; other site 272568008703 GTP/Mg2+ binding site [chemical binding]; other site 272568008704 Switch I region; other site 272568008705 G2 box; other site 272568008706 G3 box; other site 272568008707 Switch II region; other site 272568008708 G4 box; other site 272568008709 G5 box; other site 272568008710 gamma-glutamyl kinase; Provisional; Region: PRK05429 272568008711 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272568008712 nucleotide binding site [chemical binding]; other site 272568008713 homotetrameric interface [polypeptide binding]; other site 272568008714 putative phosphate binding site [ion binding]; other site 272568008715 putative allosteric binding site; other site 272568008716 PUA domain; Region: PUA; pfam01472 272568008717 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 272568008718 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272568008719 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272568008720 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272568008721 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 272568008722 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 272568008723 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 272568008724 [2Fe-2S] cluster binding site [ion binding]; other site 272568008725 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272568008726 cell division protein MraZ; Reviewed; Region: PRK00326 272568008727 MraZ protein; Region: MraZ; pfam02381 272568008728 MraW methylase family; Region: Methyltransf_5; cl17771 272568008729 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 272568008730 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 272568008731 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272568008732 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272568008733 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272568008734 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272568008735 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272568008736 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272568008737 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272568008738 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 272568008739 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272568008740 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272568008741 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 272568008742 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272568008743 Mg++ binding site [ion binding]; other site 272568008744 putative catalytic motif [active] 272568008745 putative substrate binding site [chemical binding]; other site 272568008746 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 272568008747 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272568008748 cell division protein FtsW; Region: ftsW; TIGR02614 272568008749 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272568008750 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272568008751 active site 272568008752 homodimer interface [polypeptide binding]; other site 272568008753 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272568008754 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272568008755 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272568008756 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272568008757 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272568008758 FAD binding domain; Region: FAD_binding_4; pfam01565 272568008759 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272568008760 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 272568008761 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272568008762 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272568008763 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272568008764 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272568008765 Cell division protein FtsQ; Region: FtsQ; pfam03799 272568008766 Cell division protein FtsA; Region: FtsA; smart00842 272568008767 cell division protein FtsA; Region: ftsA; TIGR01174 272568008768 Cell division protein FtsA; Region: FtsA; pfam14450 272568008769 cell division protein FtsZ; Validated; Region: PRK09330 272568008770 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272568008771 nucleotide binding site [chemical binding]; other site 272568008772 SulA interaction site; other site 272568008773 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 272568008774 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 272568008775 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 272568008776 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272568008777 Walker A/P-loop; other site 272568008778 ATP binding site [chemical binding]; other site 272568008779 Q-loop/lid; other site 272568008780 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272568008781 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272568008782 ABC transporter signature motif; other site 272568008783 Walker B; other site 272568008784 D-loop; other site 272568008785 H-loop/switch region; other site 272568008786 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272568008787 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272568008788 nucleotide binding pocket [chemical binding]; other site 272568008789 K-X-D-G motif; other site 272568008790 catalytic site [active] 272568008791 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272568008792 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272568008793 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272568008794 Dimer interface [polypeptide binding]; other site 272568008795 BRCT sequence motif; other site 272568008796 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272568008797 Domain of unknown function DUF21; Region: DUF21; pfam01595 272568008798 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272568008799 Transporter associated domain; Region: CorC_HlyC; smart01091 272568008800 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272568008801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568008802 NAD(P) binding site [chemical binding]; other site 272568008803 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272568008804 Predicted transcriptional regulator [Transcription]; Region: COG1959 272568008805 Transcriptional regulator; Region: Rrf2; pfam02082 272568008806 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568008807 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568008808 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272568008809 N-terminal domain interface [polypeptide binding]; other site 272568008810 dimer interface [polypeptide binding]; other site 272568008811 substrate binding pocket (H-site) [chemical binding]; other site 272568008812 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272568008813 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272568008814 [2Fe-2S] cluster binding site [ion binding]; other site 272568008815 Isochorismatase family; Region: Isochorismatase; pfam00857 272568008816 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 272568008817 metal binding site [ion binding]; metal-binding site 272568008818 catalytic triad [active] 272568008819 conserved cis-peptide bond; other site 272568008820 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 272568008821 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 272568008822 putative ligand binding site [chemical binding]; other site 272568008823 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272568008824 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272568008825 Walker A/P-loop; other site 272568008826 ATP binding site [chemical binding]; other site 272568008827 Q-loop/lid; other site 272568008828 ABC transporter signature motif; other site 272568008829 Walker B; other site 272568008830 D-loop; other site 272568008831 H-loop/switch region; other site 272568008832 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272568008833 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568008834 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272568008835 TM-ABC transporter signature motif; other site 272568008836 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 272568008837 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568008838 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272568008839 TM-ABC transporter signature motif; other site 272568008840 TM-ABC transporter signature motif; other site 272568008841 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272568008842 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272568008843 hydrophobic ligand binding site; other site 272568008844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 272568008845 NMT1/THI5 like; Region: NMT1; pfam09084 272568008846 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 272568008847 H+ Antiporter protein; Region: 2A0121; TIGR00900 272568008848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568008849 putative substrate translocation pore; other site 272568008850 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 272568008851 dimer interface [polypeptide binding]; other site 272568008852 putative tRNA-binding site [nucleotide binding]; other site 272568008853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272568008854 active site 272568008855 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 272568008856 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272568008857 putative active site [active] 272568008858 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 272568008859 polyol permease family; Region: 2A0118; TIGR00897 272568008860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568008861 putative substrate translocation pore; other site 272568008862 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272568008863 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272568008864 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272568008865 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272568008866 Walker A/P-loop; other site 272568008867 ATP binding site [chemical binding]; other site 272568008868 Q-loop/lid; other site 272568008869 ABC transporter signature motif; other site 272568008870 Walker B; other site 272568008871 D-loop; other site 272568008872 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272568008873 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272568008874 ATP binding site [chemical binding]; other site 272568008875 Mg++ binding site [ion binding]; other site 272568008876 motif III; other site 272568008877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568008878 nucleotide binding region [chemical binding]; other site 272568008879 ATP-binding site [chemical binding]; other site 272568008880 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272568008881 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272568008882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568008883 S-adenosylmethionine binding site [chemical binding]; other site 272568008884 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 272568008885 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 272568008886 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 272568008887 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 272568008888 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272568008889 Tetramer interface [polypeptide binding]; other site 272568008890 active site 272568008891 FMN-binding site [chemical binding]; other site 272568008892 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 272568008893 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272568008894 NAD binding site [chemical binding]; other site 272568008895 homotetramer interface [polypeptide binding]; other site 272568008896 homodimer interface [polypeptide binding]; other site 272568008897 substrate binding site [chemical binding]; other site 272568008898 active site 272568008899 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 272568008900 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272568008901 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 272568008902 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272568008903 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272568008904 Ligand Binding Site [chemical binding]; other site 272568008905 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 272568008906 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272568008907 Active Sites [active] 272568008908 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 272568008909 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272568008910 Active Sites [active] 272568008911 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272568008912 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 272568008913 G1 box; other site 272568008914 GTP/Mg2+ binding site [chemical binding]; other site 272568008915 G2 box; other site 272568008916 Switch I region; other site 272568008917 G3 box; other site 272568008918 Switch II region; other site 272568008919 G4 box; other site 272568008920 G5 box; other site 272568008921 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 272568008922 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 272568008923 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 272568008924 ligand-binding site [chemical binding]; other site 272568008925 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 272568008926 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 272568008927 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272568008928 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272568008929 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 272568008930 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 272568008931 putative acyl-acceptor binding pocket; other site 272568008932 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 272568008933 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 272568008934 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 272568008935 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 272568008936 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272568008937 putative acyl-acceptor binding pocket; other site 272568008938 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272568008939 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272568008940 Predicted methyltransferases [General function prediction only]; Region: COG0313 272568008941 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272568008942 putative SAM binding site [chemical binding]; other site 272568008943 putative homodimer interface [polypeptide binding]; other site 272568008944 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 272568008945 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 272568008946 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 272568008947 diiron binding motif [ion binding]; other site 272568008948 Uncharacterized conserved protein [Function unknown]; Region: COG1633 272568008949 CCC1-related protein family; Region: CCC1_like_1; cd02437 272568008950 glutamate--cysteine ligase; Region: PLN02611 272568008951 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 272568008952 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 272568008953 UbiA prenyltransferase family; Region: UbiA; pfam01040 272568008954 Predicted methyltransferase [General function prediction only]; Region: COG3897 272568008955 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272568008956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568008957 putative substrate translocation pore; other site 272568008958 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272568008959 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272568008960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568008961 putative substrate translocation pore; other site 272568008962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568008963 GntP family permease; Region: GntP_permease; pfam02447 272568008964 fructuronate transporter; Provisional; Region: PRK10034; cl15264 272568008965 GTP-binding protein Der; Reviewed; Region: PRK00093 272568008966 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272568008967 G1 box; other site 272568008968 GTP/Mg2+ binding site [chemical binding]; other site 272568008969 Switch I region; other site 272568008970 G2 box; other site 272568008971 Switch II region; other site 272568008972 G3 box; other site 272568008973 G4 box; other site 272568008974 G5 box; other site 272568008975 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272568008976 G1 box; other site 272568008977 GTP/Mg2+ binding site [chemical binding]; other site 272568008978 Switch I region; other site 272568008979 G2 box; other site 272568008980 G3 box; other site 272568008981 Switch II region; other site 272568008982 G4 box; other site 272568008983 G5 box; other site 272568008984 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 272568008985 Trp docking motif [polypeptide binding]; other site 272568008986 active site 272568008987 PQQ-like domain; Region: PQQ_2; pfam13360 272568008988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 272568008989 dihydroorotase; Validated; Region: PRK09060 272568008990 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272568008991 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 272568008992 active site 272568008993 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 272568008994 putative ADP-binding pocket [chemical binding]; other site 272568008995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568008996 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 272568008997 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 272568008998 putative active site [active] 272568008999 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 272568009000 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272568009001 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272568009002 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 272568009003 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272568009004 classical (c) SDRs; Region: SDR_c; cd05233 272568009005 NAD(P) binding site [chemical binding]; other site 272568009006 active site 272568009007 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 272568009008 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272568009009 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272568009010 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272568009011 putative tRNA-binding site [nucleotide binding]; other site 272568009012 B3/4 domain; Region: B3_4; pfam03483 272568009013 tRNA synthetase B5 domain; Region: B5; smart00874 272568009014 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272568009015 dimer interface [polypeptide binding]; other site 272568009016 motif 1; other site 272568009017 motif 3; other site 272568009018 motif 2; other site 272568009019 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 272568009020 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272568009021 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272568009022 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272568009023 dimer interface [polypeptide binding]; other site 272568009024 motif 1; other site 272568009025 active site 272568009026 motif 2; other site 272568009027 motif 3; other site 272568009028 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272568009029 23S rRNA binding site [nucleotide binding]; other site 272568009030 L21 binding site [polypeptide binding]; other site 272568009031 L13 binding site [polypeptide binding]; other site 272568009032 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272568009033 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272568009034 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272568009035 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272568009036 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 272568009037 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 272568009038 Trp docking motif [polypeptide binding]; other site 272568009039 putative active site [active] 272568009040 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272568009041 Cytochrome c; Region: Cytochrom_C; pfam00034 272568009042 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 272568009043 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272568009044 catalytic loop [active] 272568009045 iron binding site [ion binding]; other site 272568009046 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 272568009047 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 272568009048 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 272568009049 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272568009050 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 272568009051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568009052 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568009053 putative substrate translocation pore; other site 272568009054 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 272568009055 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272568009056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568009057 Walker A motif; other site 272568009058 ATP binding site [chemical binding]; other site 272568009059 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 272568009060 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272568009061 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 272568009062 active site 272568009063 HslU subunit interaction site [polypeptide binding]; other site 272568009064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568009065 active site 272568009066 phosphorylation site [posttranslational modification] 272568009067 intermolecular recognition site; other site 272568009068 dimerization interface [polypeptide binding]; other site 272568009069 PAS fold; Region: PAS_4; pfam08448 272568009070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568009071 dimer interface [polypeptide binding]; other site 272568009072 phosphorylation site [posttranslational modification] 272568009073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568009074 ATP binding site [chemical binding]; other site 272568009075 Mg2+ binding site [ion binding]; other site 272568009076 G-X-G motif; other site 272568009077 Response regulator receiver domain; Region: Response_reg; pfam00072 272568009078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568009079 active site 272568009080 phosphorylation site [posttranslational modification] 272568009081 intermolecular recognition site; other site 272568009082 dimerization interface [polypeptide binding]; other site 272568009083 Response regulator receiver domain; Region: Response_reg; pfam00072 272568009084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568009085 active site 272568009086 phosphorylation site [posttranslational modification] 272568009087 intermolecular recognition site; other site 272568009088 dimerization interface [polypeptide binding]; other site 272568009089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272568009090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568009091 dimer interface [polypeptide binding]; other site 272568009092 phosphorylation site [posttranslational modification] 272568009093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568009094 ATP binding site [chemical binding]; other site 272568009095 Mg2+ binding site [ion binding]; other site 272568009096 G-X-G motif; other site 272568009097 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 272568009098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568009099 active site 272568009100 phosphorylation site [posttranslational modification] 272568009101 intermolecular recognition site; other site 272568009102 dimerization interface [polypeptide binding]; other site 272568009103 CheB methylesterase; Region: CheB_methylest; pfam01339 272568009104 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272568009105 putative binding surface; other site 272568009106 active site 272568009107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568009108 ATP binding site [chemical binding]; other site 272568009109 Mg2+ binding site [ion binding]; other site 272568009110 G-X-G motif; other site 272568009111 Response regulator receiver domain; Region: Response_reg; pfam00072 272568009112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568009113 active site 272568009114 phosphorylation site [posttranslational modification] 272568009115 intermolecular recognition site; other site 272568009116 dimerization interface [polypeptide binding]; other site 272568009117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272568009118 dimerization interface [polypeptide binding]; other site 272568009119 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272568009120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272568009121 dimer interface [polypeptide binding]; other site 272568009122 putative CheW interface [polypeptide binding]; other site 272568009123 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 272568009124 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272568009125 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272568009126 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 272568009127 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272568009128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568009129 Walker A/P-loop; other site 272568009130 ATP binding site [chemical binding]; other site 272568009131 Q-loop/lid; other site 272568009132 ABC transporter signature motif; other site 272568009133 Walker B; other site 272568009134 D-loop; other site 272568009135 H-loop/switch region; other site 272568009136 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272568009137 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272568009138 putative active site [active] 272568009139 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272568009140 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272568009141 putative acyl-acceptor binding pocket; other site 272568009142 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 272568009143 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 272568009144 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 272568009145 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 272568009146 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 272568009147 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 272568009148 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 272568009149 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272568009150 NAD(P) binding site [chemical binding]; other site 272568009151 homotetramer interface [polypeptide binding]; other site 272568009152 homodimer interface [polypeptide binding]; other site 272568009153 active site 272568009154 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 272568009155 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272568009156 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272568009157 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 272568009158 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 272568009159 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272568009160 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 272568009161 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 272568009162 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 272568009163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568009164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568009165 active site 272568009166 catalytic tetrad [active] 272568009167 DNA polymerase III subunit chi; Validated; Region: PRK05728 272568009168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272568009169 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568009170 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568009171 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272568009172 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272568009173 interface (dimer of trimers) [polypeptide binding]; other site 272568009174 Substrate-binding/catalytic site; other site 272568009175 Zn-binding sites [ion binding]; other site 272568009176 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272568009177 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272568009178 active site 272568009179 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272568009180 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272568009181 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272568009182 FAD binding domain; Region: FAD_binding_4; pfam01565 272568009183 Predicted permeases [General function prediction only]; Region: COG0795 272568009184 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272568009185 Predicted permeases [General function prediction only]; Region: COG0795 272568009186 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272568009187 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 272568009188 OstA-like protein; Region: OstA; cl00844 272568009189 Organic solvent tolerance protein; Region: OstA_C; pfam04453 272568009190 SurA N-terminal domain; Region: SurA_N; pfam09312 272568009191 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272568009192 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272568009193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568009194 S-adenosylmethionine binding site [chemical binding]; other site 272568009195 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272568009196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272568009197 S-adenosylmethionine binding site [chemical binding]; other site 272568009198 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272568009199 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272568009200 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272568009201 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272568009202 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272568009203 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 272568009204 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272568009205 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272568009206 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 272568009207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272568009208 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272568009209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272568009210 DNA binding residues [nucleotide binding] 272568009211 DNA primase; Validated; Region: dnaG; PRK05667 272568009212 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272568009213 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272568009214 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272568009215 active site 272568009216 metal binding site [ion binding]; metal-binding site 272568009217 interdomain interaction site; other site 272568009218 Yqey-like protein; Region: YqeY; cl17540 272568009219 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 272568009220 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272568009221 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272568009222 catalytic site [active] 272568009223 subunit interface [polypeptide binding]; other site 272568009224 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272568009225 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272568009226 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272568009227 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 272568009228 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272568009229 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272568009230 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272568009231 IMP binding site; other site 272568009232 dimer interface [polypeptide binding]; other site 272568009233 partial ornithine binding site; other site 272568009234 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272568009235 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272568009236 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272568009237 threonine dehydratase; Provisional; Region: PRK07334 272568009238 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272568009239 tetramer interface [polypeptide binding]; other site 272568009240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568009241 catalytic residue [active] 272568009242 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 272568009243 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 272568009244 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272568009245 oligomeric interface; other site 272568009246 putative active site [active] 272568009247 homodimer interface [polypeptide binding]; other site 272568009248 Dodecin; Region: Dodecin; pfam07311 272568009249 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272568009250 active site 272568009251 SelR domain; Region: SelR; pfam01641 272568009252 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272568009253 phosphoglyceromutase; Provisional; Region: PRK05434 272568009254 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 272568009255 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272568009256 Peptidase family M23; Region: Peptidase_M23; pfam01551 272568009257 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272568009258 C-terminal peptidase (prc); Region: prc; TIGR00225 272568009259 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272568009260 protein binding site [polypeptide binding]; other site 272568009261 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272568009262 Catalytic dyad [active] 272568009263 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272568009264 putative active site [active] 272568009265 Ap4A binding site [chemical binding]; other site 272568009266 nudix motif; other site 272568009267 putative metal binding site [ion binding]; other site 272568009268 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 272568009269 nudix motif; other site 272568009270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568009271 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568009272 putative substrate translocation pore; other site 272568009273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568009274 HlyD family secretion protein; Region: HlyD; pfam00529 272568009275 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568009276 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568009277 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272568009278 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272568009279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568009280 Walker A/P-loop; other site 272568009281 ATP binding site [chemical binding]; other site 272568009282 Q-loop/lid; other site 272568009283 ABC transporter signature motif; other site 272568009284 Walker B; other site 272568009285 D-loop; other site 272568009286 H-loop/switch region; other site 272568009287 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272568009288 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272568009289 active site 272568009290 NTP binding site [chemical binding]; other site 272568009291 metal binding triad [ion binding]; metal-binding site 272568009292 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272568009293 Pleckstrin homology-like domain; Region: PH-like; cl17171 272568009294 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 272568009295 MoxR-like ATPases [General function prediction only]; Region: COG0714 272568009296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272568009297 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272568009298 Protein of unknown function DUF58; Region: DUF58; pfam01882 272568009299 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272568009300 conserved cys residue [active] 272568009301 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 272568009302 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 272568009303 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272568009304 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272568009305 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272568009306 DNA methylase; Region: N6_N4_Mtase; pfam01555 272568009307 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272568009308 RNA/DNA hybrid binding site [nucleotide binding]; other site 272568009309 active site 272568009310 CsbD-like; Region: CsbD; pfam05532 272568009311 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 272568009312 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272568009313 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568009314 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568009315 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 272568009316 Protein export membrane protein; Region: SecD_SecF; cl14618 272568009317 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 272568009318 Protein export membrane protein; Region: SecD_SecF; cl14618 272568009319 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568009320 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 272568009321 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272568009322 Ligand binding site; other site 272568009323 Putative Catalytic site; other site 272568009324 DXD motif; other site 272568009325 Methyltransferase domain; Region: Methyltransf_24; pfam13578 272568009326 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 272568009327 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 272568009328 Probable Catalytic site; other site 272568009329 metal-binding site 272568009330 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272568009331 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272568009332 Probable Catalytic site; other site 272568009333 metal-binding site 272568009334 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 272568009335 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272568009336 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 272568009337 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 272568009338 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 272568009339 Ligand binding site; other site 272568009340 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272568009341 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272568009342 NADP binding site [chemical binding]; other site 272568009343 active site 272568009344 putative substrate binding site [chemical binding]; other site 272568009345 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272568009346 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272568009347 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272568009348 substrate binding site; other site 272568009349 tetramer interface; other site 272568009350 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272568009351 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272568009352 NAD binding site [chemical binding]; other site 272568009353 substrate binding site [chemical binding]; other site 272568009354 homodimer interface [polypeptide binding]; other site 272568009355 active site 272568009356 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272568009357 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272568009358 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272568009359 alphaNTD - beta interaction site [polypeptide binding]; other site 272568009360 alphaNTD homodimer interface [polypeptide binding]; other site 272568009361 alphaNTD - beta' interaction site [polypeptide binding]; other site 272568009362 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272568009363 30S ribosomal protein S11; Validated; Region: PRK05309 272568009364 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 272568009365 30S ribosomal protein S13; Region: bact_S13; TIGR03631 272568009366 adenylate kinase; Reviewed; Region: adk; PRK00279 272568009367 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272568009368 AMP-binding site [chemical binding]; other site 272568009369 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272568009370 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272568009371 SecY translocase; Region: SecY; pfam00344 272568009372 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272568009373 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272568009374 23S rRNA binding site [nucleotide binding]; other site 272568009375 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272568009376 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272568009377 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272568009378 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272568009379 5S rRNA interface [nucleotide binding]; other site 272568009380 L5 interface [polypeptide binding]; other site 272568009381 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272568009382 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272568009383 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272568009384 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272568009385 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 272568009386 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272568009387 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272568009388 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272568009389 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272568009390 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272568009391 RNA binding site [nucleotide binding]; other site 272568009392 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272568009393 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272568009394 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272568009395 23S rRNA interface [nucleotide binding]; other site 272568009396 putative translocon interaction site; other site 272568009397 signal recognition particle (SRP54) interaction site; other site 272568009398 L23 interface [polypeptide binding]; other site 272568009399 trigger factor interaction site; other site 272568009400 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272568009401 23S rRNA interface [nucleotide binding]; other site 272568009402 5S rRNA interface [nucleotide binding]; other site 272568009403 putative antibiotic binding site [chemical binding]; other site 272568009404 L25 interface [polypeptide binding]; other site 272568009405 L27 interface [polypeptide binding]; other site 272568009406 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272568009407 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272568009408 G-X-X-G motif; other site 272568009409 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272568009410 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272568009411 putative translocon binding site; other site 272568009412 protein-rRNA interface [nucleotide binding]; other site 272568009413 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272568009414 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272568009415 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272568009416 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272568009417 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272568009418 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272568009419 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272568009420 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272568009421 elongation factor Tu; Reviewed; Region: PRK00049 272568009422 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272568009423 G1 box; other site 272568009424 GEF interaction site [polypeptide binding]; other site 272568009425 GTP/Mg2+ binding site [chemical binding]; other site 272568009426 Switch I region; other site 272568009427 G2 box; other site 272568009428 G3 box; other site 272568009429 Switch II region; other site 272568009430 G4 box; other site 272568009431 G5 box; other site 272568009432 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272568009433 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272568009434 Antibiotic Binding Site [chemical binding]; other site 272568009435 30S ribosomal protein S7; Validated; Region: PRK05302 272568009436 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272568009437 S17 interaction site [polypeptide binding]; other site 272568009438 S8 interaction site; other site 272568009439 16S rRNA interaction site [nucleotide binding]; other site 272568009440 streptomycin interaction site [chemical binding]; other site 272568009441 23S rRNA interaction site [nucleotide binding]; other site 272568009442 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272568009443 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272568009444 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 272568009445 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 272568009446 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272568009447 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272568009448 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272568009449 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 272568009450 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272568009451 DNA binding site [nucleotide binding] 272568009452 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272568009453 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272568009454 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272568009455 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272568009456 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272568009457 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 272568009458 RPB12 interaction site [polypeptide binding]; other site 272568009459 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272568009460 RPB1 interaction site [polypeptide binding]; other site 272568009461 RPB11 interaction site [polypeptide binding]; other site 272568009462 RPB10 interaction site [polypeptide binding]; other site 272568009463 RPB3 interaction site [polypeptide binding]; other site 272568009464 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272568009465 L11 interface [polypeptide binding]; other site 272568009466 putative EF-Tu interaction site [polypeptide binding]; other site 272568009467 putative EF-G interaction site [polypeptide binding]; other site 272568009468 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272568009469 23S rRNA interface [nucleotide binding]; other site 272568009470 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272568009471 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272568009472 mRNA/rRNA interface [nucleotide binding]; other site 272568009473 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272568009474 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272568009475 23S rRNA interface [nucleotide binding]; other site 272568009476 L7/L12 interface [polypeptide binding]; other site 272568009477 putative thiostrepton binding site; other site 272568009478 L25 interface [polypeptide binding]; other site 272568009479 Winged helix-turn helix; Region: HTH_33; pfam13592 272568009480 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568009481 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272568009482 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568009483 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568009484 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272568009485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272568009486 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272568009487 dimerization interface [polypeptide binding]; other site 272568009488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568009489 ATP binding site [chemical binding]; other site 272568009490 Mg2+ binding site [ion binding]; other site 272568009491 G-X-G motif; other site 272568009492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272568009493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568009494 active site 272568009495 phosphorylation site [posttranslational modification] 272568009496 intermolecular recognition site; other site 272568009497 dimerization interface [polypeptide binding]; other site 272568009498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568009499 DNA binding site [nucleotide binding] 272568009500 RmuC family; Region: RmuC; pfam02646 272568009501 Protein of unknown function; Region: DUF3971; pfam13116 272568009502 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272568009503 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 272568009504 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272568009505 metal binding triad; other site 272568009506 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272568009507 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272568009508 metal binding triad; other site 272568009509 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272568009510 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272568009511 catalytic triad [active] 272568009512 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 272568009513 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 272568009514 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 272568009515 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 272568009516 dimerization interface [polypeptide binding]; other site 272568009517 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 272568009518 ligand binding site [chemical binding]; other site 272568009519 NADP binding site [chemical binding]; other site 272568009520 catalytic site [active] 272568009521 EcsC protein family; Region: EcsC; pfam12787 272568009522 EVE domain; Region: EVE; pfam01878 272568009523 YciI-like protein; Reviewed; Region: PRK12863 272568009524 heme exporter protein CcmC; Region: ccmC; TIGR01191 272568009525 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 272568009526 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 272568009527 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568009528 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272568009529 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 272568009530 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 272568009531 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 272568009532 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 272568009533 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 272568009534 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 272568009535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 272568009536 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 272568009537 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272568009538 Beta-lactamase; Region: Beta-lactamase; pfam00144 272568009539 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272568009540 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272568009541 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272568009542 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272568009543 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272568009546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272568009547 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568009548 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568009549 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272568009550 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272568009551 active site 272568009552 catalytic tetrad [active] 272568009553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272568009554 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272568009555 putative substrate translocation pore; other site 272568009556 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568009557 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568009558 N-terminal plug; other site 272568009559 ligand-binding site [chemical binding]; other site 272568009560 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 272568009561 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 272568009562 active site 272568009563 iron coordination sites [ion binding]; other site 272568009564 substrate binding pocket [chemical binding]; other site 272568009565 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 272568009566 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272568009567 RNA binding site [nucleotide binding]; other site 272568009568 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272568009569 RNA binding site [nucleotide binding]; other site 272568009570 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272568009571 RNA binding site [nucleotide binding]; other site 272568009572 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 272568009573 RNA binding site [nucleotide binding]; other site 272568009574 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 272568009575 RNA binding site [nucleotide binding]; other site 272568009576 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 272568009577 RNA binding site [nucleotide binding]; other site 272568009578 cytidylate kinase; Provisional; Region: cmk; PRK00023 272568009579 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272568009580 CMP-binding site; other site 272568009581 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272568009582 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272568009583 hinge; other site 272568009584 active site 272568009585 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 272568009586 TIGR02300 family protein; Region: FYDLN_acid 272568009587 Dihydroneopterin aldolase; Region: FolB; smart00905 272568009588 active site 272568009589 short chain dehydrogenase; Provisional; Region: PRK09134 272568009590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568009591 NAD(P) binding site [chemical binding]; other site 272568009592 active site 272568009593 recombination protein RecR; Reviewed; Region: recR; PRK00076 272568009594 RecR protein; Region: RecR; pfam02132 272568009595 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272568009596 putative active site [active] 272568009597 putative metal-binding site [ion binding]; other site 272568009598 tetramer interface [polypeptide binding]; other site 272568009599 hypothetical protein; Validated; Region: PRK00153 272568009600 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 272568009601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568009602 Walker A motif; other site 272568009603 ATP binding site [chemical binding]; other site 272568009604 Walker B motif; other site 272568009605 arginine finger; other site 272568009606 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272568009607 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 272568009608 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 272568009609 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 272568009610 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 272568009611 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 272568009612 putative NADH binding site [chemical binding]; other site 272568009613 putative active site [active] 272568009614 nudix motif; other site 272568009615 putative metal binding site [ion binding]; other site 272568009616 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272568009617 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 272568009618 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272568009619 active site 272568009620 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272568009621 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272568009622 Uncharacterized conserved protein [Function unknown]; Region: COG2127 272568009623 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 272568009624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568009625 Walker A motif; other site 272568009626 ATP binding site [chemical binding]; other site 272568009627 Walker B motif; other site 272568009628 arginine finger; other site 272568009629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568009630 Walker A motif; other site 272568009631 ATP binding site [chemical binding]; other site 272568009632 Walker B motif; other site 272568009633 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272568009634 Predicted membrane protein [Function unknown]; Region: COG2259 272568009635 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272568009636 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272568009637 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272568009638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568009639 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272568009640 NAD(P) binding site [chemical binding]; other site 272568009641 active site 272568009642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568009643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568009644 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 272568009645 putative effector binding pocket; other site 272568009646 putative dimerization interface [polypeptide binding]; other site 272568009647 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 272568009648 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 272568009649 malonic semialdehyde reductase; Provisional; Region: PRK10538 272568009650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568009651 NAD(P) binding site [chemical binding]; other site 272568009652 active site 272568009653 hypothetical protein; Validated; Region: PRK00228 272568009654 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272568009655 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272568009656 ligand binding site [chemical binding]; other site 272568009657 flexible hinge region; other site 272568009658 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272568009659 putative switch regulator; other site 272568009660 non-specific DNA interactions [nucleotide binding]; other site 272568009661 DNA binding site [nucleotide binding] 272568009662 sequence specific DNA binding site [nucleotide binding]; other site 272568009663 putative cAMP binding site [chemical binding]; other site 272568009664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272568009665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272568009666 Coenzyme A binding pocket [chemical binding]; other site 272568009667 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 272568009668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568009669 Walker A/P-loop; other site 272568009670 ATP binding site [chemical binding]; other site 272568009671 Q-loop/lid; other site 272568009672 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568009673 ABC transporter; Region: ABC_tran_2; pfam12848 272568009674 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272568009675 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272568009676 dimer interface [polypeptide binding]; other site 272568009677 substrate binding site [chemical binding]; other site 272568009678 metal binding sites [ion binding]; metal-binding site 272568009679 hypothetical protein; Provisional; Region: PRK02237 272568009680 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272568009681 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 272568009682 putative ADP-binding pocket [chemical binding]; other site 272568009683 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272568009684 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272568009685 Sel1-like repeats; Region: SEL1; smart00671 272568009686 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272568009687 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272568009688 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272568009689 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568009690 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568009691 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 272568009692 putative active site [active] 272568009693 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272568009694 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272568009695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568009696 Walker A/P-loop; other site 272568009697 ATP binding site [chemical binding]; other site 272568009698 Q-loop/lid; other site 272568009699 ABC transporter signature motif; other site 272568009700 Walker B; other site 272568009701 D-loop; other site 272568009702 H-loop/switch region; other site 272568009703 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 272568009704 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 272568009705 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 272568009706 substrate binding pocket [chemical binding]; other site 272568009707 dimer interface [polypeptide binding]; other site 272568009708 inhibitor binding site; inhibition site 272568009709 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 272568009710 B12 binding site [chemical binding]; other site 272568009711 cobalt ligand [ion binding]; other site 272568009712 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 272568009713 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 272568009714 metal binding site [ion binding]; metal-binding site 272568009715 Colicin V production protein; Region: Colicin_V; pfam02674 272568009716 amidophosphoribosyltransferase; Provisional; Region: PRK09123 272568009717 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272568009718 active site 272568009719 tetramer interface [polypeptide binding]; other site 272568009720 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272568009721 active site 272568009722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568009723 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 272568009724 NAD(P) binding site [chemical binding]; other site 272568009725 active site 272568009726 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 272568009727 putative deacylase active site [active] 272568009728 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 272568009729 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 272568009730 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272568009731 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 272568009732 MgtC family; Region: MgtC; pfam02308 272568009733 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272568009734 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272568009735 Catalytic site [active] 272568009736 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272568009737 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272568009738 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 272568009739 BA14K-like protein; Region: BA14K; pfam07886 272568009740 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272568009741 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272568009742 generic binding surface II; other site 272568009743 generic binding surface I; other site 272568009744 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272568009745 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272568009746 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272568009747 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272568009748 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 272568009749 dinuclear metal binding motif [ion binding]; other site 272568009750 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272568009751 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272568009752 NAD binding site [chemical binding]; other site 272568009753 catalytic Zn binding site [ion binding]; other site 272568009754 structural Zn binding site [ion binding]; other site 272568009755 short chain dehydrogenase; Provisional; Region: PRK05876 272568009756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568009757 NAD(P) binding site [chemical binding]; other site 272568009758 active site 272568009759 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 272568009760 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272568009761 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 272568009762 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272568009763 DXD motif; other site 272568009764 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 272568009765 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 272568009766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272568009767 Walker A/P-loop; other site 272568009768 ATP binding site [chemical binding]; other site 272568009769 Q-loop/lid; other site 272568009770 ABC transporter signature motif; other site 272568009771 Walker B; other site 272568009772 D-loop; other site 272568009773 H-loop/switch region; other site 272568009774 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272568009775 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272568009776 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 272568009777 Walker A/P-loop; other site 272568009778 ATP binding site [chemical binding]; other site 272568009779 Q-loop/lid; other site 272568009780 ABC transporter signature motif; other site 272568009781 Walker B; other site 272568009782 D-loop; other site 272568009783 H-loop/switch region; other site 272568009784 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272568009785 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272568009786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568009787 dimer interface [polypeptide binding]; other site 272568009788 conserved gate region; other site 272568009789 putative PBP binding loops; other site 272568009790 ABC-ATPase subunit interface; other site 272568009791 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272568009792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568009793 dimer interface [polypeptide binding]; other site 272568009794 conserved gate region; other site 272568009795 ABC-ATPase subunit interface; other site 272568009796 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 272568009797 peptide binding site [polypeptide binding]; other site 272568009798 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 272568009799 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272568009800 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272568009801 Cu(I) binding site [ion binding]; other site 272568009802 DNA polymerase I; Provisional; Region: PRK05755 272568009803 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272568009804 active site 272568009805 metal binding site 1 [ion binding]; metal-binding site 272568009806 putative 5' ssDNA interaction site; other site 272568009807 metal binding site 3; metal-binding site 272568009808 metal binding site 2 [ion binding]; metal-binding site 272568009809 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272568009810 putative DNA binding site [nucleotide binding]; other site 272568009811 putative metal binding site [ion binding]; other site 272568009812 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 272568009813 active site 272568009814 catalytic site [active] 272568009815 substrate binding site [chemical binding]; other site 272568009816 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272568009817 active site 272568009818 DNA binding site [nucleotide binding] 272568009819 catalytic site [active] 272568009820 Zinc-finger domain; Region: zf-CHCC; pfam10276 272568009821 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272568009822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272568009823 Entericidin EcnA/B family; Region: Entericidin; cl02322 272568009824 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 272568009825 Bacterial SH3 domain; Region: SH3_3; pfam08239 272568009826 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 272568009827 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 272568009828 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 272568009829 Winged helix-turn helix; Region: HTH_29; pfam13551 272568009830 Integrase core domain; Region: rve; pfam00665 272568009831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568009832 Integrase core domain; Region: rve_3; pfam13683 272568009833 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 272568009834 Phage protein GP46; Region: GP46; pfam07409 272568009835 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 272568009836 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 272568009837 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 272568009838 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 272568009839 Protein of unknown function (DUF497); Region: DUF497; cl01108 272568009840 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 272568009842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568009843 Walker A motif; other site 272568009844 ATP binding site [chemical binding]; other site 272568009845 Walker B motif; other site 272568009846 arginine finger; other site 272568009848 integrase; Provisional; Region: PRK09692 272568009849 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272568009850 active site 272568009851 Int/Topo IB signature motif; other site 272568009852 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272568009853 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272568009854 active site 272568009855 Int/Topo IB signature motif; other site 272568009856 non-specific DNA binding site [nucleotide binding]; other site 272568009857 salt bridge; other site 272568009858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 272568009859 sequence-specific DNA binding site [nucleotide binding]; other site 272568009860 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 272568009861 DNA-binding interface [nucleotide binding]; DNA binding site 272568009862 hypothetical protein; Validated; Region: PRK07078 272568009863 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 272568009864 active site 272568009865 metal binding site [ion binding]; metal-binding site 272568009866 interdomain interaction site; other site 272568009867 Domain of unknown function (DUF927); Region: DUF927; pfam06048 272568009868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568009869 salt bridge; other site 272568009870 non-specific DNA binding site [nucleotide binding]; other site 272568009871 sequence-specific DNA binding site [nucleotide binding]; other site 272568009872 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272568009873 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272568009874 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272568009875 catalytic residues [active] 272568009876 catalytic nucleophile [active] 272568009877 Presynaptic Site I dimer interface [polypeptide binding]; other site 272568009878 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272568009879 Synaptic Flat tetramer interface [polypeptide binding]; other site 272568009880 Synaptic Site I dimer interface [polypeptide binding]; other site 272568009881 DNA binding site [nucleotide binding] 272568009882 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272568009883 DNA-binding interface [nucleotide binding]; DNA binding site 272568009884 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272568009885 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272568009886 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272568009887 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272568009888 amidase; Provisional; Region: PRK08137 272568009889 Amidase; Region: Amidase; cl11426 272568009890 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272568009891 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272568009892 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 272568009893 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 272568009894 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272568009895 Moco binding site; other site 272568009896 metal coordination site [ion binding]; other site 272568009897 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 272568009898 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 272568009899 SelR domain; Region: SelR; pfam01641 272568009900 methionine sulfoxide reductase A; Provisional; Region: PRK13014 272568009904 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 272568009905 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 272568009906 tetramer interface [polypeptide binding]; other site 272568009907 active site 272568009908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568009909 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568009910 Homeodomain-like domain; Region: HTH_23; pfam13384 272568009911 Winged helix-turn helix; Region: HTH_29; pfam13551 272568009912 Homeodomain-like domain; Region: HTH_32; pfam13565 272568009914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568009915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568009916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272568009917 dimerization interface [polypeptide binding]; other site 272568009918 cytosine deaminase; Provisional; Region: PRK05985 272568009919 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 272568009920 active site 272568009921 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568009922 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272568009923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 272568009924 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 272568009925 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272568009926 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272568009927 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272568009928 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272568009929 FOG: CBS domain [General function prediction only]; Region: COG0517 272568009930 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 272568009931 BON domain; Region: BON; pfam04972 272568009932 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272568009933 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272568009934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568009935 PAS fold; Region: PAS_3; pfam08447 272568009936 putative active site [active] 272568009937 heme pocket [chemical binding]; other site 272568009938 PAS fold; Region: PAS_3; pfam08447 272568009939 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568009940 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568009941 metal binding site [ion binding]; metal-binding site 272568009942 active site 272568009943 I-site; other site 272568009944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272568009945 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272568009946 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272568009947 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272568009948 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 272568009949 Cupin domain; Region: Cupin_2; cl17218 272568009950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568009951 putative DNA binding site [nucleotide binding]; other site 272568009952 putative Zn2+ binding site [ion binding]; other site 272568009953 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272568009954 ArsC family; Region: ArsC; pfam03960 272568009955 catalytic residues [active] 272568009956 arsenical pump membrane protein; Provisional; Region: PRK15445 272568009957 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272568009958 transmembrane helices; other site 272568009959 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 272568009960 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 272568009961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272568009962 motif II; other site 272568009963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 272568009964 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 272568009965 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 272568009966 hypothetical protein; Provisional; Region: PRK09256 272568009967 Predicted transcriptional regulator [Transcription]; Region: COG2932 272568009968 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272568009969 Catalytic site [active] 272568009970 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 272568009971 hypothetical protein; Validated; Region: PRK07078 272568009972 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 272568009973 Winged helix-turn helix; Region: HTH_29; pfam13551 272568009974 Integrase core domain; Region: rve; pfam00665 272568009975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568009976 Integrase core domain; Region: rve_3; pfam13683 272568009977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568009978 PAS domain; Region: PAS_9; pfam13426 272568009979 putative active site [active] 272568009980 heme pocket [chemical binding]; other site 272568009981 PAS fold; Region: PAS_7; pfam12860 272568009982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568009983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568009984 metal binding site [ion binding]; metal-binding site 272568009985 active site 272568009986 I-site; other site 272568009987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568009988 Phage terminase large subunit; Region: Terminase_3; cl12054 272568009989 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272568009990 oligomerisation interface [polypeptide binding]; other site 272568009991 mobile loop; other site 272568009992 roof hairpin; other site 272568009993 hypothetical protein; Provisional; Region: PRK10316 272568009994 Phage Tail Collar Domain; Region: Collar; pfam07484 272568009995 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 272568009996 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 272568009997 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 272568009998 heme binding site [chemical binding]; other site 272568009999 ferroxidase pore; other site 272568010000 ferroxidase diiron center [ion binding]; other site 272568010001 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 272568010002 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272568010003 ATP binding site [chemical binding]; other site 272568010004 Mg++ binding site [ion binding]; other site 272568010005 motif III; other site 272568010006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272568010007 nucleotide binding region [chemical binding]; other site 272568010008 ATP-binding site [chemical binding]; other site 272568010009 Winged helix-turn helix; Region: HTH_29; pfam13551 272568010010 Integrase core domain; Region: rve; pfam00665 272568010011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568010012 Integrase core domain; Region: rve_3; pfam13683 272568010013 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568010014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568010015 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568010016 NACHT domain; Region: NACHT; pfam05729 272568010017 Winged helix-turn helix; Region: HTH_29; pfam13551 272568010018 Integrase core domain; Region: rve; pfam00665 272568010019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568010020 Integrase core domain; Region: rve_3; pfam13683 272568010021 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272568010022 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272568010023 putative active site [active] 272568010024 putative metal binding site [ion binding]; other site 272568010025 GAF domain; Region: GAF_2; pfam13185 272568010026 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568010027 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568010028 metal binding site [ion binding]; metal-binding site 272568010029 active site 272568010030 I-site; other site 272568010031 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568010032 GAF domain; Region: GAF; pfam01590 272568010033 GAF domain; Region: GAF_2; pfam13185 272568010034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272568010035 putative active site [active] 272568010036 heme pocket [chemical binding]; other site 272568010037 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568010038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568010039 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568010040 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 272568010041 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272568010042 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 272568010043 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 272568010044 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568010045 N-terminal plug; other site 272568010046 ligand-binding site [chemical binding]; other site 272568010047 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568010048 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568010049 N-terminal plug; other site 272568010050 ligand-binding site [chemical binding]; other site 272568010051 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 272568010052 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272568010053 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272568010054 N-terminal plug; other site 272568010055 ligand-binding site [chemical binding]; other site 272568010056 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272568010057 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272568010058 FtsX-like permease family; Region: FtsX; pfam02687 272568010059 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272568010060 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272568010061 FtsX-like permease family; Region: FtsX; pfam02687 272568010062 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272568010063 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272568010064 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272568010065 FtsX-like permease family; Region: FtsX; pfam02687 272568010066 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272568010067 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272568010068 Walker A/P-loop; other site 272568010069 ATP binding site [chemical binding]; other site 272568010070 Q-loop/lid; other site 272568010071 ABC transporter signature motif; other site 272568010072 Walker B; other site 272568010073 D-loop; other site 272568010074 H-loop/switch region; other site 272568010075 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272568010076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568010077 active site 272568010078 phosphorylation site [posttranslational modification] 272568010079 intermolecular recognition site; other site 272568010080 dimerization interface [polypeptide binding]; other site 272568010081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568010082 Walker A motif; other site 272568010083 ATP binding site [chemical binding]; other site 272568010084 Walker B motif; other site 272568010085 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272568010086 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272568010087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568010088 ATP binding site [chemical binding]; other site 272568010089 Mg2+ binding site [ion binding]; other site 272568010090 G-X-G motif; other site 272568010091 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272568010092 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272568010093 Walker A/P-loop; other site 272568010094 ATP binding site [chemical binding]; other site 272568010095 Q-loop/lid; other site 272568010096 ABC transporter signature motif; other site 272568010097 Walker B; other site 272568010098 D-loop; other site 272568010099 H-loop/switch region; other site 272568010100 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272568010101 Winged helix-turn helix; Region: HTH_29; pfam13551 272568010102 Integrase core domain; Region: rve; pfam00665 272568010103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568010104 Integrase core domain; Region: rve_3; pfam13683 272568010105 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568010106 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568010107 TM-ABC transporter signature motif; other site 272568010108 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272568010109 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272568010110 TM-ABC transporter signature motif; other site 272568010111 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 272568010112 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 272568010113 ligand binding site [chemical binding]; other site 272568010114 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272568010115 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272568010116 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272568010117 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272568010118 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 272568010119 dimer interface [polypeptide binding]; other site 272568010120 substrate binding site [chemical binding]; other site 272568010121 short chain dehydrogenase; Provisional; Region: PRK06125 272568010122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568010123 NAD(P) binding site [chemical binding]; other site 272568010124 active site 272568010125 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272568010126 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272568010127 DNA binding site [nucleotide binding] 272568010128 domain linker motif; other site 272568010129 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 272568010130 putative dimerization interface [polypeptide binding]; other site 272568010131 putative ligand binding site [chemical binding]; other site 272568010132 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 272568010133 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272568010134 substrate binding [chemical binding]; other site 272568010135 active site 272568010136 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272568010137 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272568010138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272568010139 DNA-binding site [nucleotide binding]; DNA binding site 272568010140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272568010141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272568010142 homodimer interface [polypeptide binding]; other site 272568010143 catalytic residue [active] 272568010144 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 272568010145 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272568010146 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 272568010147 putative active site [active] 272568010148 catalytic triad [active] 272568010149 putative dimer interface [polypeptide binding]; other site 272568010150 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 272568010151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272568010152 Coenzyme A binding pocket [chemical binding]; other site 272568010153 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 272568010154 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 272568010155 dimerization interface [polypeptide binding]; other site 272568010156 putative ATP binding site [chemical binding]; other site 272568010157 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 272568010158 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272568010159 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 272568010160 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 272568010161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272568010162 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 272568010163 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272568010164 acyl-activating enzyme (AAE) consensus motif; other site 272568010165 AMP binding site [chemical binding]; other site 272568010166 active site 272568010167 CoA binding site [chemical binding]; other site 272568010168 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568010169 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272568010170 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272568010171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272568010172 dimerization interface [polypeptide binding]; other site 272568010173 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 272568010174 putative active cleft [active] 272568010175 short chain dehydrogenase; Provisional; Region: PRK06701 272568010176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568010177 NAD(P) binding site [chemical binding]; other site 272568010178 active site 272568010179 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 272568010180 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 272568010181 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 272568010182 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 272568010183 putative active site [active] 272568010184 catalytic site [active] 272568010185 putative metal binding site [ion binding]; other site 272568010186 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568010187 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568010188 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272568010189 MarR family; Region: MarR_2; cl17246 272568010190 Fusaric acid resistance protein family; Region: FUSC; pfam04632 272568010191 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272568010192 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272568010193 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568010194 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568010195 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568010196 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272568010197 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 272568010198 putative Cl- selectivity filter; other site 272568010199 putative pore gating glutamate residue; other site 272568010200 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272568010201 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 272568010202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568010203 ATP binding site [chemical binding]; other site 272568010204 Walker A/P-loop; other site 272568010205 Q-loop/lid; other site 272568010206 ABC transporter signature motif; other site 272568010207 Walker B; other site 272568010208 D-loop; other site 272568010209 H-loop/switch region; other site 272568010210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568010211 Walker A/P-loop; other site 272568010212 ATP binding site [chemical binding]; other site 272568010213 Q-loop/lid; other site 272568010214 ABC transporter signature motif; other site 272568010215 Walker B; other site 272568010216 D-loop; other site 272568010217 H-loop/switch region; other site 272568010218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272568010219 Ligand Binding Site [chemical binding]; other site 272568010220 CrcB-like protein; Region: CRCB; cl09114 272568010221 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272568010222 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272568010223 Predicted transcriptional regulators [Transcription]; Region: COG1733 272568010224 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272568010225 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272568010226 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272568010227 DNA binding site [nucleotide binding] 272568010228 substrate interaction site [chemical binding]; other site 272568010229 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272568010230 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 272568010231 ATP binding site [chemical binding]; other site 272568010232 Mg2+ binding site [ion binding]; other site 272568010233 G-X-G motif; other site 272568010234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272568010235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568010236 ATP binding site [chemical binding]; other site 272568010237 G-X-G motif; other site 272568010238 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 272568010239 additional DNA contacts [nucleotide binding]; other site 272568010240 mismatch recognition site; other site 272568010241 active site 272568010242 zinc binding site [ion binding]; other site 272568010243 DNA intercalation site [nucleotide binding]; other site 272568010244 Transposase domain (DUF772); Region: DUF772; pfam05598 272568010245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568010246 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272568010247 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568010248 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568010249 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568010250 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 272568010251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568010252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568010253 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272568010254 putative effector binding pocket; other site 272568010255 putative dimerization interface [polypeptide binding]; other site 272568010256 short chain dehydrogenase; Provisional; Region: PRK12744 272568010257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272568010258 NAD(P) binding site [chemical binding]; other site 272568010259 active site 272568010260 putative proline-specific permease; Provisional; Region: proY; PRK10580 272568010261 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272568010262 active site 272568010263 oligomerization interface [polypeptide binding]; other site 272568010264 metal binding site [ion binding]; metal-binding site 272568010265 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 272568010266 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272568010267 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272568010268 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272568010269 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 272568010270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272568010271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272568010272 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 272568010273 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568010274 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 272568010275 YcfA-like protein; Region: YcfA; pfam07927 272568010276 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 272568010277 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 272568010278 Integrase core domain; Region: rve; pfam00665 272568010279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272568010280 Integrase core domain; Region: rve_3; pfam13683 272568010281 Winged helix-turn helix; Region: HTH_29; pfam13551 272568010282 Winged helix-turn helix; Region: HTH_33; pfam13592 272568010283 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568010284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568010286 transposase/IS protein; Provisional; Region: PRK09183 272568010287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272568010288 Walker A motif; other site 272568010289 ATP binding site [chemical binding]; other site 272568010290 Walker B motif; other site 272568010291 arginine finger; other site 272568010292 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272568010293 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272568010294 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272568010295 POT family; Region: PTR2; cl17359 272568010296 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272568010297 DNA-binding site [nucleotide binding]; DNA binding site 272568010298 RNA-binding motif; other site 272568010299 PAS domain; Region: PAS_9; pfam13426 272568010300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568010301 putative active site [active] 272568010302 heme pocket [chemical binding]; other site 272568010303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272568010304 PAS domain; Region: PAS_9; pfam13426 272568010305 putative active site [active] 272568010306 heme pocket [chemical binding]; other site 272568010307 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272568010308 GAF domain; Region: GAF; cl17456 272568010309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568010310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568010311 metal binding site [ion binding]; metal-binding site 272568010312 active site 272568010313 I-site; other site 272568010314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272568010315 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 272568010316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568010317 dimer interface [polypeptide binding]; other site 272568010318 conserved gate region; other site 272568010319 putative PBP binding loops; other site 272568010320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272568010321 ABC-ATPase subunit interface; other site 272568010322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568010323 dimer interface [polypeptide binding]; other site 272568010324 conserved gate region; other site 272568010325 putative PBP binding loops; other site 272568010326 ABC-ATPase subunit interface; other site 272568010327 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 272568010328 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272568010329 Walker A/P-loop; other site 272568010330 ATP binding site [chemical binding]; other site 272568010331 Q-loop/lid; other site 272568010332 ABC transporter signature motif; other site 272568010333 Walker B; other site 272568010334 D-loop; other site 272568010335 H-loop/switch region; other site 272568010336 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272568010337 PhoU domain; Region: PhoU; pfam01895 272568010338 PhoU domain; Region: PhoU; pfam01895 272568010339 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 272568010340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272568010341 active site 272568010342 phosphorylation site [posttranslational modification] 272568010343 intermolecular recognition site; other site 272568010344 dimerization interface [polypeptide binding]; other site 272568010345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272568010346 DNA binding site [nucleotide binding] 272568010347 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272568010348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272568010349 dimer interface [polypeptide binding]; other site 272568010350 phosphorylation site [posttranslational modification] 272568010351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272568010352 ATP binding site [chemical binding]; other site 272568010353 Mg2+ binding site [ion binding]; other site 272568010354 G-X-G motif; other site 272568010355 PBP superfamily domain; Region: PBP_like_2; cl17296 272568010356 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 272568010357 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568010358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568010359 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568010360 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272568010361 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272568010362 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 272568010363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272568010364 sequence-specific DNA binding site [nucleotide binding]; other site 272568010365 salt bridge; other site 272568010366 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 272568010367 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568010368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568010369 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568010370 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272568010371 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272568010372 Walker A/P-loop; other site 272568010373 ATP binding site [chemical binding]; other site 272568010374 Q-loop/lid; other site 272568010375 ABC transporter signature motif; other site 272568010376 Walker B; other site 272568010377 D-loop; other site 272568010378 H-loop/switch region; other site 272568010379 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272568010380 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272568010381 substrate binding pocket [chemical binding]; other site 272568010382 membrane-bound complex binding site; other site 272568010383 hinge residues; other site 272568010384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272568010385 dimer interface [polypeptide binding]; other site 272568010386 conserved gate region; other site 272568010387 putative PBP binding loops; other site 272568010388 ABC-ATPase subunit interface; other site 272568010389 aldolase II superfamily protein; Provisional; Region: PRK07044 272568010390 intersubunit interface [polypeptide binding]; other site 272568010391 active site 272568010392 Zn2+ binding site [ion binding]; other site 272568010393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272568010394 dimerization interface [polypeptide binding]; other site 272568010395 putative DNA binding site [nucleotide binding]; other site 272568010396 putative Zn2+ binding site [ion binding]; other site 272568010397 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272568010398 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272568010399 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272568010400 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272568010401 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 272568010402 FOG: CBS domain [General function prediction only]; Region: COG0517 272568010403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 272568010404 Erythromycin esterase; Region: Erythro_esteras; pfam05139 272568010405 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 272568010406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272568010407 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568010408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272568010409 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272568010410 Q-loop/lid; other site 272568010411 ABC transporter signature motif; other site 272568010412 Walker B; other site 272568010413 D-loop; other site 272568010414 H-loop/switch region; other site 272568010415 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272568010416 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568010417 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272568010418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272568010419 metal binding site [ion binding]; metal-binding site 272568010420 active site 272568010421 I-site; other site 272568010422 Predicted acetyltransferase [General function prediction only]; Region: COG2388 272568010423 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 272568010424 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272568010425 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 272568010426 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272568010427 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272568010428 HlyD family secretion protein; Region: HlyD_3; pfam13437 272568010429 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272568010430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272568010431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272568010432 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272568010433 putative effector binding pocket; other site 272568010434 dimerization interface [polypeptide binding]; other site 272568010435 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272568010436 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272568010437 C-terminal domain interface [polypeptide binding]; other site 272568010438 GSH binding site (G-site) [chemical binding]; other site 272568010439 dimer interface [polypeptide binding]; other site 272568010441 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272568010442 ParA-like protein; Provisional; Region: PHA02518 272568010443 P-loop; other site 272568010444 Magnesium ion binding site [ion binding]; other site 272568010445 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272568010446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 272568010447 Homeodomain-like domain; Region: HTH_23; pfam13384 272568010448 Winged helix-turn helix; Region: HTH_29; pfam13551 272568010449 Homeodomain-like domain; Region: HTH_32; pfam13565 272568010450 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272568010451 DNA binding site [nucleotide binding] 272568010452 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272568010453 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568010454 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272568010455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272568010456 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272568010457 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751