-- dump date 20140619_103647 -- class Genbank::misc_feature -- table misc_feature_note -- id note 337191000001 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 337191000002 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 337191000003 P-loop; other site 337191000004 Magnesium ion binding site [ion binding]; other site 337191000005 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 337191000006 nucleotide binding site [chemical binding]; other site 337191000007 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 337191000008 Rubrerythrin [Energy production and conversion]; Region: COG1592 337191000009 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 337191000010 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 337191000011 cofactor binding site; other site 337191000012 DNA binding site [nucleotide binding] 337191000013 substrate interaction site [chemical binding]; other site 337191000014 hypothetical protein; Provisional; Region: PRK00106 337191000015 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 337191000016 generic binding surface I; other site 337191000017 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 337191000018 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 337191000019 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 337191000020 active site 337191000021 putative interdomain interaction site [polypeptide binding]; other site 337191000022 putative metal-binding site [ion binding]; other site 337191000023 putative nucleotide binding site [chemical binding]; other site 337191000024 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 337191000025 domain I; other site 337191000026 DNA binding groove [nucleotide binding] 337191000027 phosphate binding site [ion binding]; other site 337191000028 domain II; other site 337191000029 domain III; other site 337191000030 nucleotide binding site [chemical binding]; other site 337191000031 catalytic site [active] 337191000032 domain IV; other site 337191000033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191000034 non-specific DNA binding site [nucleotide binding]; other site 337191000035 salt bridge; other site 337191000036 sequence-specific DNA binding site [nucleotide binding]; other site 337191000037 DEAD-like helicases superfamily; Region: DEXDc; smart00487 337191000038 Part of AAA domain; Region: AAA_19; pfam13245 337191000039 AAA-like domain; Region: AAA_10; pfam12846 337191000040 MazG family protein; Region: mazG; TIGR00444 337191000041 Actin interacting protein 3; Region: AIP3; smart00806 337191000042 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 337191000043 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 337191000044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 337191000045 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 337191000046 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 337191000047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191000048 Walker A motif; other site 337191000049 ATP binding site [chemical binding]; other site 337191000050 Walker B motif; other site 337191000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191000052 Walker A motif; other site 337191000053 ATP binding site [chemical binding]; other site 337191000054 Walker B motif; other site 337191000055 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 337191000056 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 337191000057 Walker A motif; other site 337191000058 ATP binding site [chemical binding]; other site 337191000059 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 337191000060 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 337191000061 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 337191000062 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 337191000063 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 337191000064 active site region [active] 337191000065 catalytic site [active] 337191000066 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 337191000067 Cutinase; Region: Cutinase; pfam01083 337191000068 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 337191000069 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 337191000070 dimer interface [polypeptide binding]; other site 337191000071 ssDNA binding site [nucleotide binding]; other site 337191000072 tetramer (dimer of dimers) interface [polypeptide binding]; other site 337191000073 recombination factor protein RarA; Reviewed; Region: PRK13342 337191000074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191000075 Walker A motif; other site 337191000076 ATP binding site [chemical binding]; other site 337191000077 Walker B motif; other site 337191000078 arginine finger; other site 337191000079 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 337191000080 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 337191000081 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 337191000082 DNA binding site [nucleotide binding] 337191000083 dimer interface [polypeptide binding]; other site 337191000084 active site 337191000085 Int/Topo IB signature motif; other site 337191000086 putative transposase OrfB; Reviewed; Region: PHA02517 337191000087 HTH-like domain; Region: HTH_21; pfam13276 337191000088 Integrase core domain; Region: rve; pfam00665 337191000089 Integrase core domain; Region: rve_3; pfam13683 337191000090 Transposase; Region: HTH_Tnp_1; pfam01527 337191000091 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 337191000092 conserved FAD binding motif [chemical binding]; other site 337191000093 Integrase core domain; Region: rve; pfam00665 337191000094 AAA domain; Region: AAA_22; pfam13401 337191000095 Bacterial TniB protein; Region: TniB; pfam05621 337191000096 TniQ; Region: TniQ; pfam06527 337191000097 DEAD-like helicases superfamily; Region: DEXDc; smart00487 337191000098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191000099 ATP binding site [chemical binding]; other site 337191000100 putative Mg++ binding site [ion binding]; other site 337191000101 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 337191000102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191000103 nucleotide binding region [chemical binding]; other site 337191000104 ATP-binding site [chemical binding]; other site 337191000105 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 337191000106 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 337191000107 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 337191000108 Methyltransferase domain; Region: Methyltransf_26; pfam13659 337191000109 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 337191000110 Methyltransferase domain; Region: Methyltransf_12; pfam08242 337191000111 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 337191000112 Part of AAA domain; Region: AAA_19; pfam13245 337191000113 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 337191000114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191000115 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 337191000116 Walker A motif; other site 337191000117 ATP binding site [chemical binding]; other site 337191000118 Walker B motif; other site 337191000119 arginine finger; other site 337191000120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191000121 Walker A motif; other site 337191000122 ATP binding site [chemical binding]; other site 337191000123 Walker B motif; other site 337191000124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191000125 Walker A motif; other site 337191000126 ATP binding site [chemical binding]; other site 337191000127 Walker B motif; other site 337191000128 arginine finger; other site 337191000129 Lsr2; Region: Lsr2; pfam11774 337191000130 DEAD-like helicases superfamily; Region: DEXDc; smart00487 337191000131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191000132 ATP binding site [chemical binding]; other site 337191000133 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 337191000134 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 337191000135 catalytic residues [active] 337191000136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 337191000137 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 337191000138 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 337191000139 DHH family; Region: DHH; pfam01368 337191000140 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 337191000141 Cupin domain; Region: Cupin_2; cl17218 337191000142 Transcriptional regulators [Transcription]; Region: FadR; COG2186 337191000143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191000144 DNA-binding site [nucleotide binding]; DNA binding site 337191000145 FCD domain; Region: FCD; pfam07729 337191000146 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191000147 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 337191000148 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 337191000149 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 337191000150 ferredoxin-NADP+ reductase; Region: PLN02852 337191000151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191000152 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 337191000153 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191000154 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 337191000155 Helix-turn-helix domain; Region: HTH_17; pfam12728 337191000156 Fic/DOC family; Region: Fic; cl00960 337191000157 Helicase associated domain; Region: HA; pfam03457 337191000158 Helicase associated domain; Region: HA; pfam03457 337191000159 Helicase associated domain; Region: HA; pfam03457 337191000160 Transposase; Region: DEDD_Tnp_IS110; pfam01548 337191000161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191000162 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191000163 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 337191000164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191000165 Walker A motif; other site 337191000166 ATP binding site [chemical binding]; other site 337191000167 Walker B motif; other site 337191000168 arginine finger; other site 337191000169 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 337191000170 DnaA box-binding interface [nucleotide binding]; other site 337191000171 DNA polymerase III subunit beta; Validated; Region: PRK07761 337191000172 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 337191000173 putative DNA binding surface [nucleotide binding]; other site 337191000174 dimer interface [polypeptide binding]; other site 337191000175 beta-clamp/clamp loader binding surface; other site 337191000176 beta-clamp/translesion DNA polymerase binding surface; other site 337191000177 recombination protein F; Reviewed; Region: recF; PRK00064 337191000178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191000179 Walker A/P-loop; other site 337191000180 ATP binding site [chemical binding]; other site 337191000181 Q-loop/lid; other site 337191000182 ABC transporter signature motif; other site 337191000183 Walker B; other site 337191000184 D-loop; other site 337191000185 H-loop/switch region; other site 337191000186 hypothetical protein; Provisional; Region: PRK03195 337191000187 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 337191000188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191000189 ATP binding site [chemical binding]; other site 337191000190 Mg2+ binding site [ion binding]; other site 337191000191 G-X-G motif; other site 337191000192 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 337191000193 anchoring element; other site 337191000194 dimer interface [polypeptide binding]; other site 337191000195 ATP binding site [chemical binding]; other site 337191000196 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 337191000197 active site 337191000198 metal binding site [ion binding]; metal-binding site 337191000199 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 337191000200 DNA gyrase subunit A; Validated; Region: PRK05560 337191000201 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 337191000202 CAP-like domain; other site 337191000203 active site 337191000204 primary dimer interface [polypeptide binding]; other site 337191000205 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 337191000206 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 337191000207 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 337191000208 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 337191000209 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 337191000210 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 337191000211 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 337191000212 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 337191000213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191000214 non-specific DNA binding site [nucleotide binding]; other site 337191000215 salt bridge; other site 337191000216 sequence-specific DNA binding site [nucleotide binding]; other site 337191000217 Cupin domain; Region: Cupin_2; pfam07883 337191000218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191000219 NAD(P) binding site [chemical binding]; other site 337191000220 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 337191000221 NADP+ binding site [chemical binding]; other site 337191000222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191000223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191000224 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191000225 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191000226 active site 337191000227 ATP binding site [chemical binding]; other site 337191000228 substrate binding site [chemical binding]; other site 337191000229 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 337191000230 substrate binding site [chemical binding]; other site 337191000231 activation loop (A-loop); other site 337191000232 activation loop (A-loop); other site 337191000233 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 337191000234 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191000235 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 337191000236 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 337191000237 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 337191000238 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 337191000239 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 337191000240 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 337191000241 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 337191000242 potential catalytic triad [active] 337191000243 conserved cys residue [active] 337191000244 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 337191000245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191000246 NAD(P) binding site [chemical binding]; other site 337191000247 active site 337191000248 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 337191000249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191000250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191000251 putative substrate translocation pore; other site 337191000252 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 337191000253 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 337191000254 active site 337191000255 Rhomboid family; Region: Rhomboid; pfam01694 337191000256 putative septation inhibitor protein; Reviewed; Region: PRK00159 337191000257 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 337191000258 Glutamine amidotransferase class-I; Region: GATase; pfam00117 337191000259 glutamine binding [chemical binding]; other site 337191000260 catalytic triad [active] 337191000261 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 337191000262 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191000263 active site 337191000264 ATP binding site [chemical binding]; other site 337191000265 substrate binding site [chemical binding]; other site 337191000266 activation loop (A-loop); other site 337191000267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 337191000268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 337191000269 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 337191000270 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 337191000271 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 337191000272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191000273 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191000274 active site 337191000275 ATP binding site [chemical binding]; other site 337191000276 substrate binding site [chemical binding]; other site 337191000277 activation loop (A-loop); other site 337191000278 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 337191000279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 337191000280 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 337191000281 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 337191000282 active site 337191000283 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 337191000284 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 337191000285 phosphopeptide binding site; other site 337191000286 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 337191000287 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 337191000288 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 337191000289 phosphopeptide binding site; other site 337191000290 Domain of unknown function (DUF309); Region: DUF309; pfam03745 337191000291 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 337191000292 Domain of unknown function (DUF385); Region: DUF385; pfam04075 337191000293 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 337191000294 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 337191000295 Protein of unknown function DUF72; Region: DUF72; pfam01904 337191000296 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 337191000297 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 337191000298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191000299 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 337191000300 Walker A motif; other site 337191000301 ATP binding site [chemical binding]; other site 337191000302 Walker B motif; other site 337191000303 arginine finger; other site 337191000304 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 337191000305 TIR domain; Region: TIR_2; pfam13676 337191000306 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191000307 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191000308 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191000309 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 337191000310 catalytic loop [active] 337191000311 iron binding site [ion binding]; other site 337191000312 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 337191000313 FAD binding pocket [chemical binding]; other site 337191000314 FAD binding motif [chemical binding]; other site 337191000315 phosphate binding motif [ion binding]; other site 337191000316 beta-alpha-beta structure motif; other site 337191000317 NAD binding pocket [chemical binding]; other site 337191000318 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191000319 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 337191000320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191000321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 337191000322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191000323 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 337191000324 Na binding site [ion binding]; other site 337191000325 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 337191000326 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 337191000327 classical (c) SDRs; Region: SDR_c; cd05233 337191000328 NAD(P) binding site [chemical binding]; other site 337191000329 active site 337191000330 RibD C-terminal domain; Region: RibD_C; cl17279 337191000331 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 337191000332 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 337191000333 anti sigma factor interaction site; other site 337191000334 regulatory phosphorylation site [posttranslational modification]; other site 337191000335 Secretory lipase; Region: LIP; pfam03583 337191000336 LGFP repeat; Region: LGFP; pfam08310 337191000337 LGFP repeat; Region: LGFP; pfam08310 337191000338 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 337191000339 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191000340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191000341 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 337191000342 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 337191000343 molybdopterin cofactor binding site; other site 337191000344 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 337191000345 molybdopterin cofactor binding site; other site 337191000346 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 337191000347 Fasciclin domain; Region: Fasciclin; pfam02469 337191000348 Protein of unknown function (DUF664); Region: DUF664; pfam04978 337191000349 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 337191000350 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 337191000351 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191000352 acyl-activating enzyme (AAE) consensus motif; other site 337191000353 AMP binding site [chemical binding]; other site 337191000354 active site 337191000355 CoA binding site [chemical binding]; other site 337191000356 GAF domain; Region: GAF_2; pfam13185 337191000357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191000358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191000359 DNA binding residues [nucleotide binding] 337191000360 dimerization interface [polypeptide binding]; other site 337191000361 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 337191000362 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 337191000363 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 337191000364 NAD binding site [chemical binding]; other site 337191000365 catalytic Zn binding site [ion binding]; other site 337191000366 substrate binding site [chemical binding]; other site 337191000367 structural Zn binding site [ion binding]; other site 337191000368 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191000369 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 337191000370 active site 337191000371 catalytic triad [active] 337191000372 oxyanion hole [active] 337191000373 DNA gyrase, A subunit; Region: gyrA; TIGR01063 337191000374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191000375 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191000376 putative substrate translocation pore; other site 337191000377 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 337191000378 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 337191000379 Sulfate transporter family; Region: Sulfate_transp; pfam00916 337191000380 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 337191000381 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 337191000382 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 337191000383 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 337191000384 active site 337191000385 DNA binding site [nucleotide binding] 337191000386 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 337191000387 DNA binding site [nucleotide binding] 337191000388 Anti-sigma-K factor rskA; Region: RskA; pfam10099 337191000389 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 337191000390 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 337191000391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191000392 S-adenosylmethionine binding site [chemical binding]; other site 337191000393 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 337191000394 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 337191000395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191000396 hypothetical protein; Provisional; Region: PRK11770 337191000397 Domain of unknown function (DUF307); Region: DUF307; pfam03733 337191000398 Domain of unknown function (DUF307); Region: DUF307; pfam03733 337191000399 TIGR03086 family protein; Region: TIGR03086 337191000400 Helix-turn-helix domain; Region: HTH_18; pfam12833 337191000401 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 337191000402 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 337191000403 NAD(P) binding site [chemical binding]; other site 337191000404 catalytic residues [active] 337191000405 Protein of unknown function (DUF779); Region: DUF779; pfam05610 337191000406 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 337191000407 G1 box; other site 337191000408 GTP/Mg2+ binding site [chemical binding]; other site 337191000409 G2 box; other site 337191000410 Switch I region; other site 337191000411 G3 box; other site 337191000412 Switch II region; other site 337191000413 G4 box; other site 337191000414 G5 box; other site 337191000415 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 337191000416 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 337191000417 G1 box; other site 337191000418 GTP/Mg2+ binding site [chemical binding]; other site 337191000419 G2 box; other site 337191000420 Switch I region; other site 337191000421 G3 box; other site 337191000422 Switch II region; other site 337191000423 G4 box; other site 337191000424 G5 box; other site 337191000425 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 337191000426 nucleotide binding site [chemical binding]; other site 337191000427 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 337191000428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191000429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 337191000430 dimerization interface [polypeptide binding]; other site 337191000431 DNA binding residues [nucleotide binding] 337191000432 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 337191000433 Histidine kinase; Region: HisKA_3; pfam07730 337191000434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191000435 ATP binding site [chemical binding]; other site 337191000436 Mg2+ binding site [ion binding]; other site 337191000437 G-X-G motif; other site 337191000438 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191000439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191000440 active site 337191000441 phosphorylation site [posttranslational modification] 337191000442 intermolecular recognition site; other site 337191000443 dimerization interface [polypeptide binding]; other site 337191000444 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191000445 DNA binding residues [nucleotide binding] 337191000446 dimerization interface [polypeptide binding]; other site 337191000447 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 337191000448 metal binding site [ion binding]; metal-binding site 337191000449 nucleotidyl binding site; other site 337191000450 Predicted membrane protein [Function unknown]; Region: COG4325 337191000451 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 337191000452 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 337191000453 AAA domain; Region: AAA_22; pfam13401 337191000454 Predicted ATPase [General function prediction only]; Region: COG3899 337191000455 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191000456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191000457 DNA binding residues [nucleotide binding] 337191000458 dimerization interface [polypeptide binding]; other site 337191000459 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 337191000460 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191000461 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191000462 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 337191000463 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 337191000464 active site 337191000465 dimer interface [polypeptide binding]; other site 337191000466 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 337191000467 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 337191000468 active site 337191000469 FMN binding site [chemical binding]; other site 337191000470 substrate binding site [chemical binding]; other site 337191000471 3Fe-4S cluster binding site [ion binding]; other site 337191000472 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 337191000473 domain interface; other site 337191000474 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 337191000475 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 337191000476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191000477 Cutinase; Region: Cutinase; pfam01083 337191000478 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 337191000479 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191000480 hydrophobic ligand binding site; other site 337191000481 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 337191000482 RNA binding surface [nucleotide binding]; other site 337191000483 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 337191000484 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 337191000485 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 337191000486 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 337191000487 dimer interface [polypeptide binding]; other site 337191000488 putative anticodon binding site; other site 337191000489 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 337191000490 motif 1; other site 337191000491 dimer interface [polypeptide binding]; other site 337191000492 active site 337191000493 motif 2; other site 337191000494 motif 3; other site 337191000495 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191000496 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 337191000497 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 337191000498 NAD(P) binding site [chemical binding]; other site 337191000499 catalytic residues [active] 337191000500 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 337191000501 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 337191000502 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 337191000503 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191000504 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191000505 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191000506 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 337191000507 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 337191000508 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 337191000509 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191000510 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 337191000511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191000512 NAD(P) binding site [chemical binding]; other site 337191000513 active site 337191000514 Predicted membrane protein [Function unknown]; Region: COG2119 337191000515 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 337191000516 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 337191000517 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 337191000518 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 337191000519 Walker A/P-loop; other site 337191000520 ATP binding site [chemical binding]; other site 337191000521 Q-loop/lid; other site 337191000522 ABC transporter signature motif; other site 337191000523 Walker B; other site 337191000524 D-loop; other site 337191000525 H-loop/switch region; other site 337191000526 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 337191000527 Walker A/P-loop; other site 337191000528 ATP binding site [chemical binding]; other site 337191000529 Q-loop/lid; other site 337191000530 ABC transporter signature motif; other site 337191000531 Walker B; other site 337191000532 D-loop; other site 337191000533 H-loop/switch region; other site 337191000534 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 337191000535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191000536 Transposase; Region: DEDD_Tnp_IS110; pfam01548 337191000537 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191000538 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 337191000539 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 337191000540 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 337191000541 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 337191000542 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 337191000543 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191000544 active site 337191000545 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 337191000546 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 337191000547 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 337191000548 tandem repeat interface [polypeptide binding]; other site 337191000549 oligomer interface [polypeptide binding]; other site 337191000550 active site residues [active] 337191000551 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 337191000552 active site residue [active] 337191000553 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 337191000554 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 337191000555 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 337191000556 active site 337191000557 catalytic site [active] 337191000558 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 337191000559 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 337191000560 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 337191000561 Ferritin-like domain; Region: Ferritin; pfam00210 337191000562 ferroxidase diiron center [ion binding]; other site 337191000563 Transcriptional regulator [Transcription]; Region: LytR; COG1316 337191000564 amino acid transporter; Region: 2A0306; TIGR00909 337191000565 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 337191000566 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 337191000567 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 337191000568 CAAX protease self-immunity; Region: Abi; pfam02517 337191000569 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 337191000570 prephenate dehydratase; Provisional; Region: PRK11898 337191000571 Prephenate dehydratase; Region: PDT; pfam00800 337191000572 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 337191000573 putative L-Phe binding site [chemical binding]; other site 337191000574 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 337191000575 catalytic core [active] 337191000576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191000577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191000578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 337191000579 dimerization interface [polypeptide binding]; other site 337191000580 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 337191000581 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 337191000582 substrate binding site [chemical binding]; other site 337191000583 THF binding site; other site 337191000584 zinc-binding site [ion binding]; other site 337191000585 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 337191000586 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 337191000587 Septum formation; Region: Septum_form; pfam13845 337191000588 Septum formation; Region: Septum_form; pfam13845 337191000589 PaaX-like protein; Region: PaaX; pfam07848 337191000590 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 337191000591 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 337191000592 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191000593 active site 337191000594 enoyl-CoA hydratase; Provisional; Region: PRK08272 337191000595 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191000596 substrate binding site [chemical binding]; other site 337191000597 oxyanion hole (OAH) forming residues; other site 337191000598 trimer interface [polypeptide binding]; other site 337191000599 Cation efflux family; Region: Cation_efflux; pfam01545 337191000600 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 337191000601 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 337191000602 seryl-tRNA synthetase; Provisional; Region: PRK05431 337191000603 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 337191000604 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 337191000605 dimer interface [polypeptide binding]; other site 337191000606 active site 337191000607 motif 1; other site 337191000608 motif 2; other site 337191000609 motif 3; other site 337191000610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191000611 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 337191000612 putative dimer interface [polypeptide binding]; other site 337191000613 Secretory lipase; Region: LIP; pfam03583 337191000614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191000615 Predicted acetyltransferase [General function prediction only]; Region: COG3153 337191000616 Secretory lipase; Region: LIP; pfam03583 337191000617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191000618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191000619 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 337191000620 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 337191000621 iron-sulfur cluster [ion binding]; other site 337191000622 [2Fe-2S] cluster binding site [ion binding]; other site 337191000623 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191000624 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191000625 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 337191000626 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 337191000627 putative acyl-acceptor binding pocket; other site 337191000628 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 337191000629 putative acyl-acceptor binding pocket; other site 337191000630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191000631 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 337191000632 active site 337191000633 motif I; other site 337191000634 motif II; other site 337191000635 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 337191000636 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 337191000637 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 337191000638 amidase catalytic site [active] 337191000639 Zn binding residues [ion binding]; other site 337191000640 substrate binding site [chemical binding]; other site 337191000641 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 337191000642 Stage II sporulation protein; Region: SpoIID; pfam08486 337191000643 GAF domain; Region: GAF_2; pfam13185 337191000644 ANTAR domain; Region: ANTAR; pfam03861 337191000645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191000646 S-adenosylmethionine binding site [chemical binding]; other site 337191000647 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 337191000648 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191000649 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191000650 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191000651 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191000652 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 337191000653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191000654 UDP-galactopyranose mutase; Region: GLF; pfam03275 337191000655 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 337191000656 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 337191000657 active site 337191000658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191000659 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 337191000660 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 337191000661 active site 337191000662 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 337191000663 putative active site [active] 337191000664 Predicted esterase [General function prediction only]; Region: COG0627 337191000665 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191000666 Putative esterase; Region: Esterase; pfam00756 337191000667 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191000668 LGFP repeat; Region: LGFP; pfam08310 337191000669 Cutinase; Region: Cutinase; pfam01083 337191000670 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 337191000671 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 337191000672 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 337191000673 acyl-activating enzyme (AAE) consensus motif; other site 337191000674 active site 337191000675 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 337191000676 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 337191000677 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 337191000678 active site 337191000679 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 337191000680 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191000681 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 337191000682 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 337191000683 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 337191000684 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 337191000685 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 337191000686 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191000687 acyl-activating enzyme (AAE) consensus motif; other site 337191000688 AMP binding site [chemical binding]; other site 337191000689 active site 337191000690 CoA binding site [chemical binding]; other site 337191000691 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191000692 classical (c) SDRs; Region: SDR_c; cd05233 337191000693 NAD(P) binding site [chemical binding]; other site 337191000694 active site 337191000695 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 337191000696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191000697 putative substrate translocation pore; other site 337191000698 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191000699 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 337191000700 NAD(P) binding site [chemical binding]; other site 337191000701 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191000702 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191000703 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191000704 classical (c) SDRs; Region: SDR_c; cd05233 337191000705 NAD(P) binding site [chemical binding]; other site 337191000706 active site 337191000707 Putative cyclase; Region: Cyclase; pfam04199 337191000708 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191000709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191000710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191000711 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191000712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191000713 putative DNA binding site [nucleotide binding]; other site 337191000714 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191000715 putative Zn2+ binding site [ion binding]; other site 337191000716 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191000717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191000718 NAD(P) binding site [chemical binding]; other site 337191000719 active site 337191000720 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 337191000721 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 337191000722 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 337191000723 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 337191000724 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 337191000725 Ferritin-like domain; Region: Ferritin; pfam00210 337191000726 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 337191000727 dimerization interface [polypeptide binding]; other site 337191000728 DPS ferroxidase diiron center [ion binding]; other site 337191000729 ion pore; other site 337191000730 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 337191000731 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 337191000732 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 337191000733 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 337191000734 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 337191000735 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 337191000736 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 337191000737 trimer interface [polypeptide binding]; other site 337191000738 active site 337191000739 dimer interface [polypeptide binding]; other site 337191000740 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191000741 hydrophobic ligand binding site; other site 337191000742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191000743 dimerization interface [polypeptide binding]; other site 337191000744 putative DNA binding site [nucleotide binding]; other site 337191000745 putative Zn2+ binding site [ion binding]; other site 337191000746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191000747 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191000748 acyl-activating enzyme (AAE) consensus motif; other site 337191000749 AMP binding site [chemical binding]; other site 337191000750 active site 337191000751 CoA binding site [chemical binding]; other site 337191000752 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191000753 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191000754 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191000755 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 337191000756 putative FMN binding site [chemical binding]; other site 337191000757 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 337191000758 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191000759 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 337191000760 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 337191000761 short chain dehydrogenase; Provisional; Region: PRK07904 337191000762 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 337191000763 NAD(P) binding site [chemical binding]; other site 337191000764 active site 337191000765 FAD binding domain; Region: FAD_binding_4; pfam01565 337191000766 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 337191000767 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 337191000768 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 337191000769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191000770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191000771 WHG domain; Region: WHG; pfam13305 337191000772 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 337191000773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191000774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191000775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191000776 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 337191000777 NAD(P) binding site [chemical binding]; other site 337191000778 active site 337191000779 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 337191000780 Transport protein; Region: actII; TIGR00833 337191000781 MMPL family; Region: MMPL; pfam03176 337191000782 MMPL family; Region: MMPL; cl14618 337191000783 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 337191000784 active site 337191000785 metal binding site [ion binding]; metal-binding site 337191000786 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 337191000787 active site 337191000788 dimer interface [polypeptide binding]; other site 337191000789 non-prolyl cis peptide bond; other site 337191000790 insertion regions; other site 337191000791 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 337191000792 homodimer interface [polypeptide binding]; other site 337191000793 substrate-cofactor binding pocket; other site 337191000794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191000795 catalytic residue [active] 337191000796 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191000797 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191000798 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191000799 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 337191000800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191000801 DNA-binding site [nucleotide binding]; DNA binding site 337191000802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191000803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191000804 catalytic residue [active] 337191000805 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 337191000806 active site 337191000807 non-prolyl cis peptide bond; other site 337191000808 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191000809 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 337191000810 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191000811 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 337191000812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191000813 dimer interface [polypeptide binding]; other site 337191000814 conserved gate region; other site 337191000815 putative PBP binding loops; other site 337191000816 ABC-ATPase subunit interface; other site 337191000817 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 337191000818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191000819 dimer interface [polypeptide binding]; other site 337191000820 conserved gate region; other site 337191000821 putative PBP binding loops; other site 337191000822 ABC-ATPase subunit interface; other site 337191000823 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 337191000824 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191000825 Walker A/P-loop; other site 337191000826 ATP binding site [chemical binding]; other site 337191000827 Q-loop/lid; other site 337191000828 ABC transporter signature motif; other site 337191000829 Walker B; other site 337191000830 D-loop; other site 337191000831 H-loop/switch region; other site 337191000832 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191000833 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 337191000834 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191000835 Walker A/P-loop; other site 337191000836 ATP binding site [chemical binding]; other site 337191000837 Q-loop/lid; other site 337191000838 ABC transporter signature motif; other site 337191000839 Walker B; other site 337191000840 D-loop; other site 337191000841 H-loop/switch region; other site 337191000842 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191000843 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 337191000844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191000845 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 337191000846 active site 337191000847 catalytic tetrad [active] 337191000848 Predicted membrane protein [Function unknown]; Region: COG2246 337191000849 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 337191000850 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 337191000851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191000852 dimer interface [polypeptide binding]; other site 337191000853 conserved gate region; other site 337191000854 putative PBP binding loops; other site 337191000855 ABC-ATPase subunit interface; other site 337191000856 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 337191000857 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191000858 Walker A/P-loop; other site 337191000859 ATP binding site [chemical binding]; other site 337191000860 Q-loop/lid; other site 337191000861 ABC transporter signature motif; other site 337191000862 Walker B; other site 337191000863 D-loop; other site 337191000864 H-loop/switch region; other site 337191000865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191000866 Walker A/P-loop; other site 337191000867 ATP binding site [chemical binding]; other site 337191000868 Q-loop/lid; other site 337191000869 ABC transporter signature motif; other site 337191000870 Walker B; other site 337191000871 D-loop; other site 337191000872 H-loop/switch region; other site 337191000873 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191000874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 337191000875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191000876 dimer interface [polypeptide binding]; other site 337191000877 conserved gate region; other site 337191000878 putative PBP binding loops; other site 337191000879 ABC-ATPase subunit interface; other site 337191000880 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191000881 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 337191000882 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 337191000883 Predicted transcriptional regulators [Transcription]; Region: COG1733 337191000884 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 337191000885 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191000886 active site 2 [active] 337191000887 active site 1 [active] 337191000888 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191000889 active site 2 [active] 337191000890 active site 1 [active] 337191000891 putative transporter; Provisional; Region: PRK10504 337191000892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191000893 putative substrate translocation pore; other site 337191000894 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 337191000895 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 337191000896 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191000897 active site 337191000898 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 337191000899 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 337191000900 Walker A/P-loop; other site 337191000901 ATP binding site [chemical binding]; other site 337191000902 Q-loop/lid; other site 337191000903 ABC transporter signature motif; other site 337191000904 Walker B; other site 337191000905 D-loop; other site 337191000906 H-loop/switch region; other site 337191000907 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 337191000908 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 337191000909 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191000910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191000911 catalytic residue [active] 337191000912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191000913 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191000914 putative DNA binding site [nucleotide binding]; other site 337191000915 putative Zn2+ binding site [ion binding]; other site 337191000916 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 337191000917 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 337191000918 NAD(P) binding site [chemical binding]; other site 337191000919 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 337191000920 putative catalytic site [active] 337191000921 putative metal binding site [ion binding]; other site 337191000922 putative phosphate binding site [ion binding]; other site 337191000923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191000924 S-adenosylmethionine binding site [chemical binding]; other site 337191000925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191000926 dimerization interface [polypeptide binding]; other site 337191000927 putative DNA binding site [nucleotide binding]; other site 337191000928 putative Zn2+ binding site [ion binding]; other site 337191000929 SCP-2 sterol transfer family; Region: SCP2; cl01225 337191000930 Acyltransferase family; Region: Acyl_transf_3; cl19154 337191000931 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 337191000932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191000933 Walker A/P-loop; other site 337191000934 ATP binding site [chemical binding]; other site 337191000935 Q-loop/lid; other site 337191000936 ABC transporter signature motif; other site 337191000937 Walker B; other site 337191000938 D-loop; other site 337191000939 H-loop/switch region; other site 337191000940 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 337191000941 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 337191000942 oligomer interface [polypeptide binding]; other site 337191000943 metal binding site [ion binding]; metal-binding site 337191000944 metal binding site [ion binding]; metal-binding site 337191000945 putative Cl binding site [ion binding]; other site 337191000946 aspartate ring; other site 337191000947 basic sphincter; other site 337191000948 hydrophobic gate; other site 337191000949 periplasmic entrance; other site 337191000950 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 337191000951 active site 337191000952 Putative esterase; Region: Esterase; pfam00756 337191000953 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191000954 putative aminotransferase; Provisional; Region: PRK03321 337191000955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191000956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191000957 homodimer interface [polypeptide binding]; other site 337191000958 catalytic residue [active] 337191000959 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 337191000960 Part of AAA domain; Region: AAA_19; pfam13245 337191000961 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 337191000962 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 337191000963 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 337191000964 prephenate dehydrogenase; Validated; Region: PRK08507 337191000965 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 337191000966 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 337191000967 nucleoside/Zn binding site; other site 337191000968 dimer interface [polypeptide binding]; other site 337191000969 catalytic motif [active] 337191000970 CsbD-like; Region: CsbD; cl17424 337191000971 MspA; Region: MspA; pfam09203 337191000972 MspA; Region: MspA; pfam09203 337191000973 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191000974 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 337191000975 DNA binding residues [nucleotide binding] 337191000976 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 337191000977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191000978 acyl-activating enzyme (AAE) consensus motif; other site 337191000979 AMP binding site [chemical binding]; other site 337191000980 active site 337191000981 CoA binding site [chemical binding]; other site 337191000982 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 337191000983 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 337191000984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191000985 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 337191000986 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 337191000987 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 337191000988 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 337191000989 Sulfate transporter family; Region: Sulfate_transp; cl19250 337191000990 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 337191000991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191000992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191000993 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 337191000994 EamA-like transporter family; Region: EamA; pfam00892 337191000995 EamA-like transporter family; Region: EamA; pfam00892 337191000996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191000997 Transposase; Region: DEDD_Tnp_IS110; pfam01548 337191000998 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191000999 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 337191001000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191001001 Coenzyme A binding pocket [chemical binding]; other site 337191001002 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 337191001003 OsmC-like protein; Region: OsmC; pfam02566 337191001004 amphi-Trp domain; Region: amphi-Trp; TIGR04354 337191001005 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 337191001006 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 337191001007 putative active site [active] 337191001008 putative metal binding site [ion binding]; other site 337191001009 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 337191001010 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 337191001011 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 337191001012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191001013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191001014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 337191001015 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191001016 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001017 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 337191001018 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 337191001019 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 337191001020 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 337191001021 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 337191001022 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 337191001023 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 337191001024 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 337191001025 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 337191001026 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 337191001027 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 337191001028 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 337191001029 NADH dehydrogenase subunit G; Validated; Region: PRK07860 337191001030 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191001031 catalytic loop [active] 337191001032 iron binding site [ion binding]; other site 337191001033 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 337191001034 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 337191001035 molybdopterin cofactor binding site; other site 337191001036 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 337191001037 molybdopterin cofactor binding site; other site 337191001038 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 337191001039 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 337191001040 putative dimer interface [polypeptide binding]; other site 337191001041 [2Fe-2S] cluster binding site [ion binding]; other site 337191001042 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 337191001043 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 337191001044 SLBB domain; Region: SLBB; pfam10531 337191001045 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 337191001046 NADH dehydrogenase subunit D; Validated; Region: PRK06075 337191001047 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 337191001048 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 337191001049 NADH dehydrogenase subunit B; Validated; Region: PRK06411 337191001050 NADH dehydrogenase subunit A; Validated; Region: PRK07928 337191001051 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 337191001052 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 337191001053 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 337191001054 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 337191001055 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 337191001056 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 337191001057 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 337191001058 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191001059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191001060 catalytic residue [active] 337191001061 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191001062 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 337191001063 DNA binding residues [nucleotide binding] 337191001064 dimer interface [polypeptide binding]; other site 337191001065 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 337191001066 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 337191001067 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 337191001068 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191001069 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191001070 active site 337191001071 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 337191001072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191001073 NAD(P) binding site [chemical binding]; other site 337191001074 active site 337191001075 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 337191001076 substrate binding site [chemical binding]; other site 337191001077 ATP binding site [chemical binding]; other site 337191001078 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 337191001079 intersubunit interface [polypeptide binding]; other site 337191001080 active site 337191001081 Zn2+ binding site [ion binding]; other site 337191001082 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 337191001083 Domain of unknown function DUF21; Region: DUF21; pfam01595 337191001084 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 337191001085 Transporter associated domain; Region: CorC_HlyC; pfam03471 337191001086 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 337191001087 Domain of unknown function DUF21; Region: DUF21; pfam01595 337191001088 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 337191001089 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 337191001090 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 337191001091 active site 337191001092 nucleotide binding site [chemical binding]; other site 337191001093 HIGH motif; other site 337191001094 KMSKS motif; other site 337191001095 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 337191001096 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 337191001097 active site 337191001098 DNA binding site [nucleotide binding] 337191001099 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 337191001100 DNA binding site [nucleotide binding] 337191001101 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 337191001102 nucleotide binding site [chemical binding]; other site 337191001103 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 337191001104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191001105 NAD(P) binding site [chemical binding]; other site 337191001106 active site 337191001107 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 337191001108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191001109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191001110 homodimer interface [polypeptide binding]; other site 337191001111 catalytic residue [active] 337191001112 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 337191001113 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 337191001114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191001115 Walker A motif; other site 337191001116 ATP binding site [chemical binding]; other site 337191001117 Walker B motif; other site 337191001118 arginine finger; other site 337191001119 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 337191001120 Protein of unknown function (DUF1032); Region: DUF1032; pfam06278 337191001121 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 337191001122 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 337191001123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191001124 S-adenosylmethionine binding site [chemical binding]; other site 337191001125 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 337191001126 FAD binding domain; Region: FAD_binding_4; cl19922 337191001127 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 337191001128 hydrophobic ligand binding site; other site 337191001129 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 337191001130 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 337191001131 active site 337191001132 hypothetical protein; Validated; Region: PRK00153 337191001133 recombination protein RecR; Reviewed; Region: recR; PRK00076 337191001134 RecR protein; Region: RecR; pfam02132 337191001135 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 337191001136 putative active site [active] 337191001137 putative metal-binding site [ion binding]; other site 337191001138 tetramer interface [polypeptide binding]; other site 337191001139 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001140 TAP-like protein; Region: Abhydrolase_4; pfam08386 337191001141 hypothetical protein; Provisional; Region: PRK06547 337191001142 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 337191001143 Fe-S cluster binding site [ion binding]; other site 337191001144 DNA binding site [nucleotide binding] 337191001145 active site 337191001146 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 337191001147 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 337191001148 catalytic triad [active] 337191001149 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 337191001150 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 337191001151 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191001152 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191001153 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 337191001154 EamA-like transporter family; Region: EamA; pfam00892 337191001155 EamA-like transporter family; Region: EamA; pfam00892 337191001156 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 337191001157 catalytic residues [active] 337191001158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191001159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191001160 putative DNA binding site [nucleotide binding]; other site 337191001161 dimerization interface [polypeptide binding]; other site 337191001162 putative Zn2+ binding site [ion binding]; other site 337191001163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 337191001164 dimerization interface [polypeptide binding]; other site 337191001165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191001166 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191001167 active site 337191001168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001170 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 337191001171 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 337191001172 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191001173 dimer interface [polypeptide binding]; other site 337191001174 active site 337191001175 Uncharacterized conserved protein [Function unknown]; Region: COG1359 337191001176 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 337191001177 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191001178 2-isopropylmalate synthase; Validated; Region: PRK03739 337191001179 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 337191001180 active site 337191001181 catalytic residues [active] 337191001182 metal binding site [ion binding]; metal-binding site 337191001183 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 337191001184 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191001185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191001186 putative substrate translocation pore; other site 337191001187 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 337191001188 active site 337191001189 catalytic residues [active] 337191001190 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 337191001191 FMN binding site [chemical binding]; other site 337191001192 dimer interface [polypeptide binding]; other site 337191001193 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 337191001194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191001195 putative substrate translocation pore; other site 337191001196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001198 WHG domain; Region: WHG; pfam13305 337191001199 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 337191001200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 337191001201 Predicted integral membrane protein [Function unknown]; Region: COG5542 337191001202 aspartate kinase; Reviewed; Region: PRK06635 337191001203 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 337191001204 putative nucleotide binding site [chemical binding]; other site 337191001205 putative catalytic residues [active] 337191001206 putative Mg ion binding site [ion binding]; other site 337191001207 putative aspartate binding site [chemical binding]; other site 337191001208 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 337191001209 putative allosteric regulatory site; other site 337191001210 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 337191001211 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 337191001212 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 337191001213 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 337191001214 Transcriptional regulators [Transcription]; Region: FadR; COG2186 337191001215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 337191001216 DNA-binding site [nucleotide binding]; DNA binding site 337191001217 FCD domain; Region: FCD; pfam07729 337191001218 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 337191001219 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 337191001220 ATP-binding site [chemical binding]; other site 337191001221 Gluconate-6-phosphate binding site [chemical binding]; other site 337191001222 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 337191001223 GntP family permease; Region: GntP_permease; pfam02447 337191001224 Secretory lipase; Region: LIP; pfam03583 337191001225 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 337191001226 Ferritin-like domain; Region: Ferritin; pfam00210 337191001227 dimerization interface [polypeptide binding]; other site 337191001228 DPS ferroxidase diiron center [ion binding]; other site 337191001229 ion pore; other site 337191001230 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 337191001231 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 337191001232 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 337191001233 active site 337191001234 metal binding site [ion binding]; metal-binding site 337191001235 dimer interface [polypeptide binding]; other site 337191001236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191001237 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 337191001238 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191001239 active site 337191001240 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 337191001241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191001242 Lipocalin-like domain; Region: Lipocalin_2; cl19222 337191001243 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 337191001244 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 337191001245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191001246 motif II; other site 337191001247 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 337191001248 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 337191001249 putative active site [active] 337191001250 putative metal binding site [ion binding]; other site 337191001251 Transglycosylase; Region: Transgly; pfam00912 337191001252 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 337191001253 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 337191001254 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 337191001255 Transcription factor WhiB; Region: Whib; pfam02467 337191001256 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 337191001257 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191001258 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 337191001259 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 337191001260 P loop; other site 337191001261 Nucleotide binding site [chemical binding]; other site 337191001262 DTAP/Switch II; other site 337191001263 Switch I; other site 337191001264 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 337191001265 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 337191001266 homotrimer interaction site [polypeptide binding]; other site 337191001267 putative active site [active] 337191001268 hypothetical protein; Provisional; Region: PRK10621 337191001269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191001270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191001271 putative substrate translocation pore; other site 337191001272 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 337191001273 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 337191001274 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 337191001275 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191001276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 337191001277 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 337191001278 ligand binding site [chemical binding]; other site 337191001279 flexible hinge region; other site 337191001280 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 337191001281 putative switch regulator; other site 337191001282 non-specific DNA interactions [nucleotide binding]; other site 337191001283 DNA binding site [nucleotide binding] 337191001284 sequence specific DNA binding site [nucleotide binding]; other site 337191001285 putative cAMP binding site [chemical binding]; other site 337191001286 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 337191001287 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 337191001288 minor groove reading motif; other site 337191001289 helix-hairpin-helix signature motif; other site 337191001290 substrate binding pocket [chemical binding]; other site 337191001291 active site 337191001292 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 337191001293 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 337191001294 catalytic residues [active] 337191001295 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 337191001296 putative active site [active] 337191001297 putative CoA binding site [chemical binding]; other site 337191001298 nudix motif; other site 337191001299 metal binding site [ion binding]; metal-binding site 337191001300 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 337191001301 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 337191001302 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191001304 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001305 PGAP1-like protein; Region: PGAP1; pfam07819 337191001306 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001307 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 337191001308 acetyl-CoA synthetase; Provisional; Region: PRK00174 337191001309 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 337191001310 active site 337191001311 CoA binding site [chemical binding]; other site 337191001312 acyl-activating enzyme (AAE) consensus motif; other site 337191001313 AMP binding site [chemical binding]; other site 337191001314 acetate binding site [chemical binding]; other site 337191001315 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 337191001316 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 337191001317 Walker A motif; other site 337191001318 ATP binding site [chemical binding]; other site 337191001319 Walker B motif; other site 337191001320 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 337191001321 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 337191001322 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 337191001323 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 337191001324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191001325 ATP binding site [chemical binding]; other site 337191001326 putative Mg++ binding site [ion binding]; other site 337191001327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191001328 nucleotide binding region [chemical binding]; other site 337191001329 ATP-binding site [chemical binding]; other site 337191001330 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 337191001331 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 337191001332 DNA-binding site [nucleotide binding]; DNA binding site 337191001333 RNA-binding motif; other site 337191001334 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 337191001335 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 337191001336 active site 337191001337 interdomain interaction site; other site 337191001338 putative metal-binding site [ion binding]; other site 337191001339 nucleotide binding site [chemical binding]; other site 337191001340 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 337191001341 domain I; other site 337191001342 DNA binding groove [nucleotide binding] 337191001343 phosphate binding site [ion binding]; other site 337191001344 domain II; other site 337191001345 domain III; other site 337191001346 nucleotide binding site [chemical binding]; other site 337191001347 catalytic site [active] 337191001348 domain IV; other site 337191001349 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 337191001350 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 337191001351 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 337191001352 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 337191001353 dimerization interface [polypeptide binding]; other site 337191001354 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 337191001355 cyclase homology domain; Region: CHD; cd07302 337191001356 nucleotidyl binding site; other site 337191001357 metal binding site [ion binding]; metal-binding site 337191001358 dimer interface [polypeptide binding]; other site 337191001359 DNA polymerase III subunit delta'; Validated; Region: PRK07940 337191001360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191001361 Walker A motif; other site 337191001362 ATP binding site [chemical binding]; other site 337191001363 Walker B motif; other site 337191001364 arginine finger; other site 337191001365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191001366 dimerization interface [polypeptide binding]; other site 337191001367 putative DNA binding site [nucleotide binding]; other site 337191001368 putative Zn2+ binding site [ion binding]; other site 337191001369 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 337191001370 putative hydrophobic ligand binding site [chemical binding]; other site 337191001371 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001372 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191001373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001375 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 337191001376 Lipase (class 2); Region: Lipase_2; pfam01674 337191001377 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191001378 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 337191001379 glycogen branching enzyme; Provisional; Region: PRK12568 337191001380 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 337191001381 aromatic arch; other site 337191001382 DCoH dimer interaction site [polypeptide binding]; other site 337191001383 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 337191001384 DCoH tetramer interaction site [polypeptide binding]; other site 337191001385 substrate binding site [chemical binding]; other site 337191001386 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 337191001387 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 337191001388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 337191001389 DNA-binding site [nucleotide binding]; DNA binding site 337191001390 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 337191001391 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 337191001392 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 337191001393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191001394 motif II; other site 337191001395 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 337191001396 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 337191001397 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 337191001398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191001399 Walker A/P-loop; other site 337191001400 ATP binding site [chemical binding]; other site 337191001401 Q-loop/lid; other site 337191001402 ABC transporter signature motif; other site 337191001403 Walker B; other site 337191001404 D-loop; other site 337191001405 H-loop/switch region; other site 337191001406 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 337191001407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191001408 dimer interface [polypeptide binding]; other site 337191001409 conserved gate region; other site 337191001410 putative PBP binding loops; other site 337191001411 ABC-ATPase subunit interface; other site 337191001412 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 337191001413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191001414 dimer interface [polypeptide binding]; other site 337191001415 conserved gate region; other site 337191001416 putative PBP binding loops; other site 337191001417 ABC-ATPase subunit interface; other site 337191001418 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 337191001419 catalytic Zn binding site [ion binding]; other site 337191001420 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 337191001421 structural Zn binding site [ion binding]; other site 337191001422 tetramer interface [polypeptide binding]; other site 337191001423 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 337191001424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191001425 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 337191001426 Malic enzyme, N-terminal domain; Region: malic; pfam00390 337191001427 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 337191001428 NAD(P) binding pocket [chemical binding]; other site 337191001429 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191001430 DNA-binding site [nucleotide binding]; DNA binding site 337191001431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 337191001432 FCD domain; Region: FCD; pfam07729 337191001433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191001434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191001435 putative substrate translocation pore; other site 337191001436 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 337191001437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191001438 UDP-glucose 4-epimerase; Region: PLN02240 337191001439 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 337191001440 NAD binding site [chemical binding]; other site 337191001441 homodimer interface [polypeptide binding]; other site 337191001442 active site 337191001443 substrate binding site [chemical binding]; other site 337191001444 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 337191001445 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 337191001446 NAD binding site [chemical binding]; other site 337191001447 substrate binding site [chemical binding]; other site 337191001448 homodimer interface [polypeptide binding]; other site 337191001449 active site 337191001450 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 337191001451 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 337191001452 substrate binding site; other site 337191001453 tetramer interface; other site 337191001454 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 337191001455 ABC-2 type transporter; Region: ABC2_membrane; cl17235 337191001456 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 337191001457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191001458 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 337191001459 Walker A/P-loop; other site 337191001460 ATP binding site [chemical binding]; other site 337191001461 Q-loop/lid; other site 337191001462 ABC transporter signature motif; other site 337191001463 Walker B; other site 337191001464 D-loop; other site 337191001465 H-loop/switch region; other site 337191001466 EXLDI protein; Region: EXLDI; TIGR04342 337191001467 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 337191001468 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 337191001469 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 337191001470 Ligand binding site; other site 337191001471 Putative Catalytic site; other site 337191001472 DXD motif; other site 337191001473 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 337191001474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 337191001475 active site 337191001476 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 337191001477 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 337191001478 Zn binding site [ion binding]; other site 337191001479 Predicted membrane protein [Function unknown]; Region: COG2259 337191001480 Clp amino terminal domain; Region: Clp_N; pfam02861 337191001481 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 337191001482 DinB superfamily; Region: DinB_2; pfam12867 337191001483 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 337191001484 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 337191001485 Methyltransferase domain; Region: Methyltransf_25; pfam13649 337191001486 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 337191001487 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 337191001488 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 337191001489 Short C-terminal domain; Region: SHOCT; pfam09851 337191001490 Domain of unknown function (DUF389); Region: DUF389; pfam04087 337191001491 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 337191001492 ThiC-associated domain; Region: ThiC-associated; pfam13667 337191001493 ThiC family; Region: ThiC; pfam01964 337191001494 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 337191001495 dimer interface [polypeptide binding]; other site 337191001496 substrate binding site [chemical binding]; other site 337191001497 ATP binding site [chemical binding]; other site 337191001498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191001499 Coenzyme A binding pocket [chemical binding]; other site 337191001500 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 337191001501 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 337191001502 acyl-activating enzyme (AAE) consensus motif; other site 337191001503 active site 337191001504 AMP binding site [chemical binding]; other site 337191001505 substrate binding site [chemical binding]; other site 337191001506 salicylate synthase MbtI; Reviewed; Region: PRK07912 337191001507 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 337191001508 Phosphopantetheine attachment site; Region: PP-binding; cl09936 337191001509 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191001510 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191001511 active site 337191001512 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191001513 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 337191001514 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 337191001515 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 337191001516 intersubunit interface [polypeptide binding]; other site 337191001517 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 337191001518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191001519 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191001520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191001521 catalytic residue [active] 337191001522 Condensation domain; Region: Condensation; cl19241 337191001523 Penicillin amidase; Region: Penicil_amidase; pfam01804 337191001524 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 337191001525 active site 337191001526 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 337191001527 IucA / IucC family; Region: IucA_IucC; pfam04183 337191001528 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 337191001529 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 337191001530 Phosphopantetheine attachment site; Region: PP-binding; cl09936 337191001531 Phosphopantetheine attachment site; Region: PP-binding; cl09936 337191001532 Condensation domain; Region: Condensation; cl19241 337191001533 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191001534 Nonribosomal peptide synthase; Region: NRPS; pfam08415 337191001535 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191001536 acyl-activating enzyme (AAE) consensus motif; other site 337191001537 AMP binding site [chemical binding]; other site 337191001538 active site 337191001539 CoA binding site [chemical binding]; other site 337191001540 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191001541 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 337191001542 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191001543 acyl-activating enzyme (AAE) consensus motif; other site 337191001544 AMP binding site [chemical binding]; other site 337191001545 active site 337191001546 CoA binding site [chemical binding]; other site 337191001547 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 337191001548 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 337191001549 FAD binding pocket [chemical binding]; other site 337191001550 FAD binding motif [chemical binding]; other site 337191001551 phosphate binding motif [ion binding]; other site 337191001552 NAD binding pocket [chemical binding]; other site 337191001553 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 337191001554 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191001555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191001556 putative DNA binding site [nucleotide binding]; other site 337191001557 putative Zn2+ binding site [ion binding]; other site 337191001558 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 337191001559 putative catalytic site [active] 337191001560 putative phosphate binding site [ion binding]; other site 337191001561 active site 337191001562 metal binding site A [ion binding]; metal-binding site 337191001563 DNA binding site [nucleotide binding] 337191001564 putative AP binding site [nucleotide binding]; other site 337191001565 putative metal binding site B [ion binding]; other site 337191001566 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 337191001567 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 337191001568 active site 337191001569 catalytic residues [active] 337191001570 metal binding site [ion binding]; metal-binding site 337191001571 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001572 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191001573 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 337191001574 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 337191001575 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 337191001576 E-class dimer interface [polypeptide binding]; other site 337191001577 P-class dimer interface [polypeptide binding]; other site 337191001578 active site 337191001579 Cu2+ binding site [ion binding]; other site 337191001580 Zn2+ binding site [ion binding]; other site 337191001581 carboxylate-amine ligase; Provisional; Region: PRK13517 337191001582 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 337191001583 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 337191001584 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 337191001585 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 337191001586 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 337191001587 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 337191001588 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 337191001589 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 337191001590 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 337191001591 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 337191001592 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 337191001593 aldehyde dehydrogenase family 2 member; Region: PLN02466 337191001594 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 337191001595 NAD binding site [chemical binding]; other site 337191001596 catalytic residues [active] 337191001597 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 337191001598 classical (c) SDRs; Region: SDR_c; cd05233 337191001599 NAD(P) binding site [chemical binding]; other site 337191001600 active site 337191001601 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 337191001602 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191001603 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 337191001604 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 337191001605 [2Fe-2S] cluster binding site [ion binding]; other site 337191001606 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 337191001607 putative alpha subunit interface [polypeptide binding]; other site 337191001608 putative active site [active] 337191001609 putative substrate binding site [chemical binding]; other site 337191001610 Fe binding site [ion binding]; other site 337191001611 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 337191001612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191001613 acyl-activating enzyme (AAE) consensus motif; other site 337191001614 AMP binding site [chemical binding]; other site 337191001615 active site 337191001616 CoA binding site [chemical binding]; other site 337191001617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001619 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191001620 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191001621 active site 337191001622 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191001623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191001624 NAD(P) binding site [chemical binding]; other site 337191001625 active site 337191001626 enoyl-CoA hydratase; Provisional; Region: PRK08252 337191001627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191001628 substrate binding site [chemical binding]; other site 337191001629 oxyanion hole (OAH) forming residues; other site 337191001630 trimer interface [polypeptide binding]; other site 337191001631 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191001632 enoyl-CoA hydratase; Provisional; Region: PRK08260 337191001633 substrate binding site [chemical binding]; other site 337191001634 oxyanion hole (OAH) forming residues; other site 337191001635 trimer interface [polypeptide binding]; other site 337191001636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191001637 NAD(P) binding site [chemical binding]; other site 337191001638 active site 337191001639 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 337191001640 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 337191001641 putative NAD(P) binding site [chemical binding]; other site 337191001642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001644 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001646 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 337191001647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191001648 NAD(P) binding site [chemical binding]; other site 337191001649 active site 337191001650 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 337191001651 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 337191001652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191001653 active site 337191001654 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 337191001655 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 337191001656 acyl-activating enzyme (AAE) consensus motif; other site 337191001657 putative AMP binding site [chemical binding]; other site 337191001658 putative active site [active] 337191001659 putative CoA binding site [chemical binding]; other site 337191001660 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191001661 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191001662 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191001663 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191001664 active site 337191001665 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191001666 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191001667 active site 337191001668 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191001669 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 337191001670 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 337191001671 putative FMN binding site [chemical binding]; other site 337191001672 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191001674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001678 enoyl-CoA hydratase; Provisional; Region: PRK08140 337191001679 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191001680 substrate binding site [chemical binding]; other site 337191001681 oxyanion hole (OAH) forming residues; other site 337191001682 trimer interface [polypeptide binding]; other site 337191001683 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 337191001684 NAD(P) binding site [chemical binding]; other site 337191001685 catalytic residues [active] 337191001686 Permease; Region: Permease; pfam02405 337191001687 Permease; Region: Permease; pfam02405 337191001688 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191001689 mce related protein; Region: MCE; pfam02470 337191001690 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191001691 mce related protein; Region: MCE; pfam02470 337191001692 mce related protein; Region: MCE; pfam02470 337191001693 Glucuronate isomerase; Region: UxaC; cl00829 337191001694 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191001695 mce related protein; Region: MCE; pfam02470 337191001696 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191001697 mce related protein; Region: MCE; pfam02470 337191001698 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 337191001699 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 337191001700 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 337191001701 Walker A/P-loop; other site 337191001702 ATP binding site [chemical binding]; other site 337191001703 Q-loop/lid; other site 337191001704 ABC transporter signature motif; other site 337191001705 Walker B; other site 337191001706 D-loop; other site 337191001707 H-loop/switch region; other site 337191001708 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 337191001709 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 337191001710 active site 337191001711 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 337191001712 DUF35 OB-fold domain; Region: DUF35; pfam01796 337191001713 lipid-transfer protein; Provisional; Region: PRK07855 337191001714 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 337191001715 active site 337191001716 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 337191001717 NAD binding site [chemical binding]; other site 337191001718 catalytic residues [active] 337191001719 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191001720 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191001721 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 337191001722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191001723 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191001724 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 337191001725 FMN-binding pocket [chemical binding]; other site 337191001726 flavin binding motif; other site 337191001727 phosphate binding motif [ion binding]; other site 337191001728 beta-alpha-beta structure motif; other site 337191001729 NAD binding pocket [chemical binding]; other site 337191001730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191001731 catalytic loop [active] 337191001732 iron binding site [ion binding]; other site 337191001733 tetracycline repressor protein TetR; Provisional; Region: PRK13756 337191001734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001735 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 337191001736 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191001737 Ligand Binding Site [chemical binding]; other site 337191001738 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191001739 Ligand Binding Site [chemical binding]; other site 337191001740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191001741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191001742 putative substrate translocation pore; other site 337191001743 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 337191001744 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 337191001745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191001746 Walker A motif; other site 337191001747 ATP binding site [chemical binding]; other site 337191001748 Walker B motif; other site 337191001749 arginine finger; other site 337191001750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191001751 Walker A motif; other site 337191001752 ATP binding site [chemical binding]; other site 337191001753 Walker B motif; other site 337191001754 arginine finger; other site 337191001755 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 337191001756 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 337191001757 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 337191001758 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 337191001759 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 337191001760 dimer interface [polypeptide binding]; other site 337191001761 putative functional site; other site 337191001762 putative MPT binding site; other site 337191001763 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 337191001764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191001765 active site 337191001766 motif I; other site 337191001767 motif II; other site 337191001768 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 337191001769 hydrophobic ligand binding site; other site 337191001770 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 337191001771 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 337191001772 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191001773 active site 337191001774 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 337191001775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191001776 active site 337191001777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191001780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191001781 putative substrate translocation pore; other site 337191001782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001784 amidase; Provisional; Region: PRK07869 337191001785 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 337191001786 Na binding site [ion binding]; other site 337191001787 Protein of unknown function, DUF485; Region: DUF485; pfam04341 337191001788 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 337191001789 Na binding site [ion binding]; other site 337191001790 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 337191001791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191001792 active site 337191001793 phosphorylation site [posttranslational modification] 337191001794 intermolecular recognition site; other site 337191001795 dimerization interface [polypeptide binding]; other site 337191001796 LytTr DNA-binding domain; Region: LytTR; smart00850 337191001797 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 337191001798 Histidine kinase; Region: His_kinase; pfam06580 337191001799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191001800 ATP binding site [chemical binding]; other site 337191001801 Mg2+ binding site [ion binding]; other site 337191001802 G-X-G motif; other site 337191001803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191001806 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 337191001807 NAD(P) binding site [chemical binding]; other site 337191001808 active site 337191001809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191001810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191001811 S-adenosylmethionine binding site [chemical binding]; other site 337191001812 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 337191001813 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 337191001814 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 337191001815 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 337191001816 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 337191001817 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191001818 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 337191001819 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 337191001820 ring oligomerisation interface [polypeptide binding]; other site 337191001821 ATP/Mg binding site [chemical binding]; other site 337191001822 stacking interactions; other site 337191001823 hinge regions; other site 337191001824 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191001825 active site 337191001826 metal binding site [ion binding]; metal-binding site 337191001827 Predicted transcriptional regulators [Transcription]; Region: COG1733 337191001828 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 337191001829 catalytic residues [active] 337191001830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191001831 Coenzyme A binding pocket [chemical binding]; other site 337191001832 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191001833 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191001834 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 337191001835 active site 337191001836 non-prolyl cis peptide bond; other site 337191001837 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191001838 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 337191001839 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 337191001840 N-terminal domain interface [polypeptide binding]; other site 337191001841 dimer interface [polypeptide binding]; other site 337191001842 substrate binding pocket (H-site) [chemical binding]; other site 337191001843 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191001844 FAD dependent oxidoreductase; Region: DAO; pfam01266 337191001845 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 337191001846 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191001847 Walker A/P-loop; other site 337191001848 ATP binding site [chemical binding]; other site 337191001849 Q-loop/lid; other site 337191001850 ABC transporter signature motif; other site 337191001851 Walker B; other site 337191001852 D-loop; other site 337191001853 H-loop/switch region; other site 337191001854 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191001855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191001856 Walker A/P-loop; other site 337191001857 ATP binding site [chemical binding]; other site 337191001858 Q-loop/lid; other site 337191001859 ABC transporter signature motif; other site 337191001860 Walker B; other site 337191001861 D-loop; other site 337191001862 H-loop/switch region; other site 337191001863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191001864 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 337191001865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191001866 dimer interface [polypeptide binding]; other site 337191001867 conserved gate region; other site 337191001868 putative PBP binding loops; other site 337191001869 ABC-ATPase subunit interface; other site 337191001870 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 337191001871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191001872 dimer interface [polypeptide binding]; other site 337191001873 conserved gate region; other site 337191001874 putative PBP binding loops; other site 337191001875 ABC-ATPase subunit interface; other site 337191001876 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191001877 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 337191001878 Restriction endonuclease; Region: Mrr_cat; cl19295 337191001879 Putative esterase; Region: Esterase; pfam00756 337191001880 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191001881 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 337191001882 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 337191001883 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 337191001884 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 337191001885 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 337191001886 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 337191001887 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191001888 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 337191001889 CoenzymeA binding site [chemical binding]; other site 337191001890 subunit interaction site [polypeptide binding]; other site 337191001891 PHB binding site; other site 337191001892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001894 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 337191001895 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 337191001896 putative hydrophobic ligand binding site [chemical binding]; other site 337191001897 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 337191001898 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 337191001899 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 337191001900 dimer interface [polypeptide binding]; other site 337191001901 PYR/PP interface [polypeptide binding]; other site 337191001902 TPP binding site [chemical binding]; other site 337191001903 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 337191001904 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 337191001905 TPP-binding site [chemical binding]; other site 337191001906 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 337191001907 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 337191001908 putative metal binding site [ion binding]; other site 337191001909 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 337191001910 putative NEF/HSP70 interaction site [polypeptide binding]; other site 337191001911 nucleotide binding site [chemical binding]; other site 337191001912 SBD interface [polypeptide binding]; other site 337191001913 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 337191001914 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 337191001915 Beta-lactamase; Region: Beta-lactamase; pfam00144 337191001916 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 337191001917 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 337191001918 active site 337191001919 FMN binding site [chemical binding]; other site 337191001920 substrate binding site [chemical binding]; other site 337191001921 putative catalytic residue [active] 337191001922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001924 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 337191001925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191001926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191001927 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 337191001928 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 337191001929 minor groove reading motif; other site 337191001930 helix-hairpin-helix signature motif; other site 337191001931 active site 337191001932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191001933 S-adenosylmethionine binding site [chemical binding]; other site 337191001934 Uncharacterized conserved protein [Function unknown]; Region: COG2128 337191001935 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 337191001936 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 337191001937 putative active site [active] 337191001938 putative catalytic site [active] 337191001939 Secretory lipase; Region: LIP; pfam03583 337191001940 Secretory lipase; Region: LIP; pfam03583 337191001941 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191001942 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191001943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191001944 non-specific DNA binding site [nucleotide binding]; other site 337191001945 salt bridge; other site 337191001946 sequence-specific DNA binding site [nucleotide binding]; other site 337191001947 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 337191001948 Domain of unknown function (DUF955); Region: DUF955; pfam06114 337191001949 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 337191001950 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 337191001951 tetramer interface [polypeptide binding]; other site 337191001952 active site 337191001953 Mg2+/Mn2+ binding site [ion binding]; other site 337191001954 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 337191001955 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 337191001956 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 337191001957 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191001958 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191001959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191001960 non-specific DNA binding site [nucleotide binding]; other site 337191001961 salt bridge; other site 337191001962 sequence-specific DNA binding site [nucleotide binding]; other site 337191001963 Cupin domain; Region: Cupin_2; cl17218 337191001964 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 337191001965 Sulfate transporter family; Region: Sulfate_transp; cl19250 337191001966 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 337191001967 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 337191001968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191001969 NAD(P) binding site [chemical binding]; other site 337191001970 active site 337191001971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191001972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191001973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 337191001974 Protein of unknown function (DUF445); Region: DUF445; pfam04286 337191001975 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191001976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191001977 non-specific DNA binding site [nucleotide binding]; other site 337191001978 salt bridge; other site 337191001979 sequence-specific DNA binding site [nucleotide binding]; other site 337191001980 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 337191001981 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 337191001982 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 337191001983 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191001984 DNA binding residues [nucleotide binding] 337191001985 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191001986 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191001987 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191001988 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 337191001989 FAD binding domain; Region: FAD_binding_4; cl19922 337191001990 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 337191001991 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 337191001992 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 337191001993 Methyltransferase domain; Region: Methyltransf_18; pfam12847 337191001994 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 337191001995 putative active site [active] 337191001996 catalytic triad [active] 337191001997 putative dimer interface [polypeptide binding]; other site 337191001998 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 337191001999 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 337191002000 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 337191002001 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 337191002002 putative active site [active] 337191002003 putative substrate binding site [chemical binding]; other site 337191002004 putative cosubstrate binding site; other site 337191002005 catalytic site [active] 337191002006 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 337191002007 intersubunit interface [polypeptide binding]; other site 337191002008 active site 337191002009 catalytic residue [active] 337191002010 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 337191002011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191002012 S-adenosylmethionine binding site [chemical binding]; other site 337191002013 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191002014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191002015 non-specific DNA binding site [nucleotide binding]; other site 337191002016 salt bridge; other site 337191002017 sequence-specific DNA binding site [nucleotide binding]; other site 337191002018 Cupin domain; Region: Cupin_2; pfam07883 337191002019 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 337191002020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 337191002021 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 337191002022 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 337191002023 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 337191002024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191002025 NAD(P) binding site [chemical binding]; other site 337191002026 active site 337191002027 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 337191002028 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 337191002029 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 337191002030 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 337191002031 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 337191002032 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl19859 337191002033 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 337191002034 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 337191002035 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 337191002036 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 337191002037 active site 337191002038 homotetramer interface [polypeptide binding]; other site 337191002039 Uncharacterized conserved protein [Function unknown]; Region: COG2966 337191002040 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 337191002041 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 337191002042 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 337191002043 homotrimer interaction site [polypeptide binding]; other site 337191002044 putative active site [active] 337191002045 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191002046 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 337191002047 Bacterial transcriptional regulator; Region: IclR; pfam01614 337191002048 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191002049 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 337191002050 Bacterial transcriptional regulator; Region: IclR; pfam01614 337191002051 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 337191002052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 337191002053 Integrase core domain; Region: rve; pfam00665 337191002054 Integrase core domain; Region: rve_3; pfam13683 337191002055 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 337191002056 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 337191002057 DctM-like transporters; Region: DctM; pfam06808 337191002058 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 337191002059 enoyl-CoA hydratase; Provisional; Region: PRK06688 337191002060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191002061 substrate binding site [chemical binding]; other site 337191002062 oxyanion hole (OAH) forming residues; other site 337191002063 trimer interface [polypeptide binding]; other site 337191002064 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 337191002065 homotrimer interaction site [polypeptide binding]; other site 337191002066 putative active site [active] 337191002067 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 337191002068 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 337191002069 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 337191002070 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 337191002071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 337191002072 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 337191002073 active site 337191002074 catalytic tetrad [active] 337191002075 Amidohydrolase; Region: Amidohydro_2; pfam04909 337191002076 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 337191002077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191002078 acyl-activating enzyme (AAE) consensus motif; other site 337191002079 AMP binding site [chemical binding]; other site 337191002080 active site 337191002081 CoA binding site [chemical binding]; other site 337191002082 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 337191002083 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 337191002084 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 337191002085 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 337191002086 Phosphotransferase enzyme family; Region: APH; pfam01636 337191002087 putative active site [active] 337191002088 putative substrate binding site [chemical binding]; other site 337191002089 ATP binding site [chemical binding]; other site 337191002090 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191002091 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 337191002092 FMN-binding pocket [chemical binding]; other site 337191002093 flavin binding motif; other site 337191002094 phosphate binding motif [ion binding]; other site 337191002095 beta-alpha-beta structure motif; other site 337191002096 NAD binding pocket [chemical binding]; other site 337191002097 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191002098 catalytic loop [active] 337191002099 iron binding site [ion binding]; other site 337191002100 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 337191002101 iron-sulfur cluster [ion binding]; other site 337191002102 [2Fe-2S] cluster binding site [ion binding]; other site 337191002103 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191002104 hydrophobic ligand binding site; other site 337191002105 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 337191002106 active site 337191002107 metal binding site [ion binding]; metal-binding site 337191002108 Putative cyclase; Region: Cyclase; pfam04199 337191002109 Putative cyclase; Region: Cyclase; cl00814 337191002110 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 337191002111 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 337191002112 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191002113 acyl-activating enzyme (AAE) consensus motif; other site 337191002114 AMP binding site [chemical binding]; other site 337191002115 active site 337191002116 CoA binding site [chemical binding]; other site 337191002117 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 337191002118 NAD(P) binding site [chemical binding]; other site 337191002119 catalytic residues [active] 337191002120 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191002121 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 337191002122 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 337191002123 catalytic Zn binding site [ion binding]; other site 337191002124 NAD binding site [chemical binding]; other site 337191002125 structural Zn binding site [ion binding]; other site 337191002126 CoA-transferase family III; Region: CoA_transf_3; cl19215 337191002127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002129 active site 337191002130 short chain dehydrogenase; Provisional; Region: PRK06172 337191002131 classical (c) SDRs; Region: SDR_c; cd05233 337191002132 NAD(P) binding site [chemical binding]; other site 337191002133 active site 337191002134 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 337191002135 active site 337191002136 catalytic tetrad [active] 337191002137 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 337191002138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191002139 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 337191002140 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 337191002141 substrate binding pocket [chemical binding]; other site 337191002142 catalytic triad [active] 337191002143 AAA ATPase domain; Region: AAA_16; pfam13191 337191002144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 337191002145 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 337191002146 structural tetrad; other site 337191002147 FOG: WD40 repeat [General function prediction only]; Region: COG2319 337191002148 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 337191002149 structural tetrad; other site 337191002150 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 337191002151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191002152 dimerization interface [polypeptide binding]; other site 337191002153 putative DNA binding site [nucleotide binding]; other site 337191002154 putative Zn2+ binding site [ion binding]; other site 337191002155 arsenical-resistance protein; Region: acr3; TIGR00832 337191002156 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 337191002157 active site 337191002158 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191002159 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 337191002160 putative metal binding site [ion binding]; other site 337191002161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191002162 dimerization interface [polypeptide binding]; other site 337191002163 putative DNA binding site [nucleotide binding]; other site 337191002164 putative Zn2+ binding site [ion binding]; other site 337191002165 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 337191002166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 337191002167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191002168 active site 337191002169 phosphorylation site [posttranslational modification] 337191002170 intermolecular recognition site; other site 337191002171 dimerization interface [polypeptide binding]; other site 337191002172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191002173 DNA binding site [nucleotide binding] 337191002174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 337191002175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 337191002176 dimerization interface [polypeptide binding]; other site 337191002177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191002178 dimer interface [polypeptide binding]; other site 337191002179 phosphorylation site [posttranslational modification] 337191002180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191002181 ATP binding site [chemical binding]; other site 337191002182 Mg2+ binding site [ion binding]; other site 337191002183 G-X-G motif; other site 337191002184 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 337191002185 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 337191002186 nucleotide binding site/active site [active] 337191002187 HIT family signature motif; other site 337191002188 catalytic residue [active] 337191002189 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 337191002190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191002191 ATP binding site [chemical binding]; other site 337191002192 putative Mg++ binding site [ion binding]; other site 337191002193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191002194 nucleotide binding region [chemical binding]; other site 337191002195 ATP-binding site [chemical binding]; other site 337191002196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191002197 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 337191002198 Ligand binding site; other site 337191002199 Ligand binding site; other site 337191002200 Ligand binding site; other site 337191002201 Putative Catalytic site; other site 337191002202 DXD motif; other site 337191002203 GtrA-like protein; Region: GtrA; pfam04138 337191002204 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 337191002205 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 337191002206 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 337191002207 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 337191002208 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 337191002209 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 337191002210 Putative esterase; Region: Esterase; pfam00756 337191002211 S-formylglutathione hydrolase; Region: PLN02442 337191002212 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 337191002213 nucleoside/Zn binding site; other site 337191002214 dimer interface [polypeptide binding]; other site 337191002215 catalytic motif [active] 337191002216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 337191002217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191002218 adenylosuccinate lyase; Region: purB; TIGR00928 337191002219 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 337191002220 tetramer interface [polypeptide binding]; other site 337191002221 Rdx family; Region: Rdx; cl01407 337191002222 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 337191002223 ATP binding site [chemical binding]; other site 337191002224 active site 337191002225 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 337191002226 substrate binding site [chemical binding]; other site 337191002227 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 337191002228 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 337191002229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191002230 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 337191002231 putative substrate translocation pore; other site 337191002232 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191002233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191002234 putative Zn2+ binding site [ion binding]; other site 337191002235 putative DNA binding site [nucleotide binding]; other site 337191002236 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 337191002237 catalytic residues [active] 337191002238 dimer interface [polypeptide binding]; other site 337191002239 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 337191002240 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 337191002241 putative active site [active] 337191002242 catalytic triad [active] 337191002243 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 337191002244 active site 337191002245 metal binding site [ion binding]; metal-binding site 337191002246 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 337191002247 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 337191002248 N-acetyl-D-glucosamine binding site [chemical binding]; other site 337191002249 catalytic residue [active] 337191002250 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 337191002251 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 337191002252 putative dimer interface [polypeptide binding]; other site 337191002253 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 337191002254 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 337191002255 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 337191002256 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191002257 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 337191002258 DNA binding residues [nucleotide binding] 337191002259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191002260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191002261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191002262 choline dehydrogenase; Validated; Region: PRK02106 337191002263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191002264 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191002265 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 337191002266 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 337191002267 NAD(P) binding site [chemical binding]; other site 337191002268 catalytic residues [active] 337191002269 BCCT family transporter; Region: BCCT; cl00569 337191002270 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191002271 active site 337191002272 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191002273 active site 337191002274 Clp protease ATP binding subunit; Region: clpC; CHL00095 337191002275 Clp amino terminal domain; Region: Clp_N; pfam02861 337191002276 Clp amino terminal domain; Region: Clp_N; pfam02861 337191002277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191002278 Walker A motif; other site 337191002279 ATP binding site [chemical binding]; other site 337191002280 Walker B motif; other site 337191002281 arginine finger; other site 337191002282 UvrB/uvrC motif; Region: UVR; pfam02151 337191002283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191002284 Walker A motif; other site 337191002285 ATP binding site [chemical binding]; other site 337191002286 Walker B motif; other site 337191002287 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 337191002288 enoyl-CoA hydratase; Provisional; Region: PRK08260 337191002289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191002290 substrate binding site [chemical binding]; other site 337191002291 oxyanion hole (OAH) forming residues; other site 337191002292 trimer interface [polypeptide binding]; other site 337191002293 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191002294 active site 337191002295 Domain of unknown function (DUF305); Region: DUF305; pfam03713 337191002296 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 337191002297 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 337191002298 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 337191002299 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 337191002300 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 337191002301 H+ Antiporter protein; Region: 2A0121; TIGR00900 337191002302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191002303 putative substrate translocation pore; other site 337191002304 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191002305 active site 2 [active] 337191002306 active site 1 [active] 337191002307 Predicted esterase [General function prediction only]; Region: COG0627 337191002308 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191002309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191002310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191002311 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002312 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 337191002313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002314 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 337191002315 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002316 active site 337191002317 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002321 active site 337191002322 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191002323 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 337191002324 DUF35 OB-fold domain; Region: DUF35; pfam01796 337191002325 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 337191002326 putative active site [active] 337191002327 putative catalytic site [active] 337191002328 lipid-transfer protein; Provisional; Region: PRK07855 337191002329 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 337191002330 active site 337191002331 acyl-CoA synthetase; Validated; Region: PRK07798 337191002332 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191002333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191002334 acyl-activating enzyme (AAE) consensus motif; other site 337191002335 acyl-activating enzyme (AAE) consensus motif; other site 337191002336 AMP binding site [chemical binding]; other site 337191002337 active site 337191002338 CoA binding site [chemical binding]; other site 337191002339 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 337191002340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191002341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191002342 putative substrate translocation pore; other site 337191002343 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 337191002344 transmembrane helices; other site 337191002345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191002346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191002347 putative substrate translocation pore; other site 337191002348 enoyl-CoA hydratase; Region: PLN02864 337191002349 N-terminal half of MaoC dehydratase; Region: MaoC_dehydrat_N; pfam13452 337191002350 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 337191002351 dimer interaction site [polypeptide binding]; other site 337191002352 substrate-binding tunnel; other site 337191002353 active site 337191002354 catalytic site [active] 337191002355 substrate binding site [chemical binding]; other site 337191002356 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 337191002357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191002358 Putative esterase; Region: Esterase; pfam00756 337191002359 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191002360 SnoaL-like domain; Region: SnoaL_2; pfam12680 337191002361 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 337191002362 active site 337191002363 TDP-binding site; other site 337191002364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191002365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191002366 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 337191002367 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002369 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002370 active site 337191002371 enoyl-CoA hydratase; Provisional; Region: PRK05870 337191002372 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191002373 substrate binding site [chemical binding]; other site 337191002374 oxyanion hole (OAH) forming residues; other site 337191002375 trimer interface [polypeptide binding]; other site 337191002376 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 337191002377 acetaldehyde dehydrogenase; Validated; Region: PRK08300 337191002378 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 337191002379 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 337191002380 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 337191002381 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 337191002382 active site 337191002383 catalytic residues [active] 337191002384 metal binding site [ion binding]; metal-binding site 337191002385 DmpG-like communication domain; Region: DmpG_comm; pfam07836 337191002386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191002387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191002388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 337191002389 dimerization interface [polypeptide binding]; other site 337191002390 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 337191002391 gating phenylalanine in ion channel; other site 337191002392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191002393 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 337191002394 putative substrate translocation pore; other site 337191002395 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 337191002396 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 337191002397 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 337191002398 NlpC/P60 family; Region: NLPC_P60; pfam00877 337191002399 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 337191002400 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 337191002401 iron-sulfur cluster [ion binding]; other site 337191002402 [2Fe-2S] cluster binding site [ion binding]; other site 337191002403 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191002404 hydrophobic ligand binding site; other site 337191002405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002406 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 337191002407 Flavin binding site [chemical binding]; other site 337191002408 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 337191002409 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 337191002410 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 337191002411 active site 337191002412 Fe binding site [ion binding]; other site 337191002413 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 337191002414 short chain dehydrogenase; Provisional; Region: PRK07890 337191002415 classical (c) SDRs; Region: SDR_c; cd05233 337191002416 NAD(P) binding site [chemical binding]; other site 337191002417 active site 337191002418 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 337191002419 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 337191002420 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 337191002421 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 337191002422 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191002423 active site 337191002424 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002425 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 337191002426 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002427 active site 337191002428 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002429 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002430 active site 337191002431 enoyl-CoA hydratase; Provisional; Region: PRK08290 337191002432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191002433 substrate binding site [chemical binding]; other site 337191002434 oxyanion hole (OAH) forming residues; other site 337191002435 trimer interface [polypeptide binding]; other site 337191002436 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191002437 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 337191002438 NlpB/DapX lipoprotein; Region: Lipoprotein_18; cl19507 337191002439 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 337191002440 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 337191002441 Active Sites [active] 337191002442 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 337191002443 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 337191002444 CysD dimerization site [polypeptide binding]; other site 337191002445 G1 box; other site 337191002446 putative GEF interaction site [polypeptide binding]; other site 337191002447 GTP/Mg2+ binding site [chemical binding]; other site 337191002448 Switch I region; other site 337191002449 G2 box; other site 337191002450 G3 box; other site 337191002451 Switch II region; other site 337191002452 G4 box; other site 337191002453 G5 box; other site 337191002454 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 337191002455 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 337191002456 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 337191002457 ligand-binding site [chemical binding]; other site 337191002458 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 337191002459 active site 337191002460 transcription termination factor Rho; Provisional; Region: PRK12678 337191002461 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 337191002462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191002463 Walker A motif; other site 337191002464 ATP binding site [chemical binding]; other site 337191002465 Walker B motif; other site 337191002466 arginine finger; other site 337191002467 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 337191002468 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 337191002469 dimerization interface [polypeptide binding]; other site 337191002470 ATP binding site [chemical binding]; other site 337191002471 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 337191002472 dimerization interface [polypeptide binding]; other site 337191002473 ATP binding site [chemical binding]; other site 337191002474 Interferon-induced transmembrane protein; Region: Dispanin; pfam04505 337191002475 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 337191002476 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 337191002477 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 337191002478 active site 337191002479 catalytic site [active] 337191002480 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 337191002481 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 337191002482 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 337191002483 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 337191002484 amidophosphoribosyltransferase; Provisional; Region: PRK07847 337191002485 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 337191002486 active site 337191002487 tetramer interface [polypeptide binding]; other site 337191002488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191002489 active site 337191002490 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 337191002491 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 337191002492 dimerization interface [polypeptide binding]; other site 337191002493 putative ATP binding site [chemical binding]; other site 337191002494 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 337191002495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 337191002496 MOSC domain; Region: MOSC; pfam03473 337191002497 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 337191002498 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 337191002499 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 337191002500 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 337191002501 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 337191002502 homodimer interface [polypeptide binding]; other site 337191002503 substrate-cofactor binding pocket; other site 337191002504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191002505 catalytic residue [active] 337191002506 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 337191002507 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 337191002508 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 337191002509 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 337191002510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191002511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191002512 Walker A/P-loop; other site 337191002513 ATP binding site [chemical binding]; other site 337191002514 Q-loop/lid; other site 337191002515 ABC transporter signature motif; other site 337191002516 Walker B; other site 337191002517 D-loop; other site 337191002518 H-loop/switch region; other site 337191002519 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 337191002520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191002521 Walker A/P-loop; other site 337191002522 ATP binding site [chemical binding]; other site 337191002523 Q-loop/lid; other site 337191002524 ABC transporter signature motif; other site 337191002525 Walker B; other site 337191002526 D-loop; other site 337191002527 H-loop/switch region; other site 337191002528 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 337191002529 NAD binding site [chemical binding]; other site 337191002530 catalytic residues [active] 337191002531 ATP-dependent protease La (LON) domain; Region: LON; cl19481 337191002532 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 337191002533 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191002534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191002535 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 337191002536 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191002537 catalytic site [active] 337191002538 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 337191002539 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 337191002540 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 337191002541 minor groove reading motif; other site 337191002542 helix-hairpin-helix signature motif; other site 337191002543 substrate binding pocket [chemical binding]; other site 337191002544 active site 337191002545 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 337191002546 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 337191002547 active site clefts [active] 337191002548 zinc binding site [ion binding]; other site 337191002549 dimer interface [polypeptide binding]; other site 337191002550 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 337191002551 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 337191002552 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 337191002553 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 337191002554 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191002555 CoenzymeA binding site [chemical binding]; other site 337191002556 subunit interaction site [polypeptide binding]; other site 337191002557 PHB binding site; other site 337191002558 DNA repair protein RadA; Provisional; Region: PRK11823 337191002559 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 337191002560 Walker A motif; other site 337191002561 ATP binding site [chemical binding]; other site 337191002562 Walker B motif; other site 337191002563 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 337191002564 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 337191002565 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 337191002566 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 337191002567 substrate binding site; other site 337191002568 dimer interface; other site 337191002569 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 337191002570 homotrimer interaction site [polypeptide binding]; other site 337191002571 zinc binding site [ion binding]; other site 337191002572 CDP-binding sites; other site 337191002573 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 337191002574 homodimer interface [polypeptide binding]; other site 337191002575 active site 337191002576 TDP-binding site; other site 337191002577 acceptor substrate-binding pocket; other site 337191002578 peptide synthase; Provisional; Region: PRK12467 337191002579 Predicted esterase [General function prediction only]; Region: COG0627 337191002580 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191002581 Condensation domain; Region: Condensation; cl19241 337191002582 Condensation domain; Region: Condensation; cl19241 337191002583 peptide synthase; Provisional; Region: PRK12316 337191002584 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 337191002585 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 337191002586 active site 337191002587 HIGH motif; other site 337191002588 KMSKS motif; other site 337191002589 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 337191002590 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 337191002591 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 337191002592 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 337191002593 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 337191002594 putative active site [active] 337191002595 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 337191002596 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 337191002597 substrate binding pocket [chemical binding]; other site 337191002598 catalytic triad [active] 337191002599 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 337191002600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191002601 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 337191002602 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 337191002603 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 337191002604 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 337191002605 DXD motif; other site 337191002606 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 337191002607 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 337191002608 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 337191002609 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 337191002610 ABC-ATPase subunit interface; other site 337191002611 dimer interface [polypeptide binding]; other site 337191002612 putative PBP binding regions; other site 337191002613 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 337191002614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191002615 Walker A/P-loop; other site 337191002616 ATP binding site [chemical binding]; other site 337191002617 Q-loop/lid; other site 337191002618 ABC transporter signature motif; other site 337191002619 Walker B; other site 337191002620 D-loop; other site 337191002621 H-loop/switch region; other site 337191002622 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 337191002623 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 337191002624 intersubunit interface [polypeptide binding]; other site 337191002625 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 337191002626 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 337191002627 putative ADP-binding pocket [chemical binding]; other site 337191002628 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 337191002629 4-coumarate--CoA ligase; Region: PLN02246 337191002630 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 337191002631 acyl-activating enzyme (AAE) consensus motif; other site 337191002632 active site 337191002633 putative CoA binding site [chemical binding]; other site 337191002634 AMP binding site [chemical binding]; other site 337191002635 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 337191002636 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 337191002637 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 337191002638 catalytic core [active] 337191002639 GCN5-related N-acetyl-transferase; Region: Acetyltransf_CG; pfam14542 337191002640 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 337191002641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191002642 dimer interface [polypeptide binding]; other site 337191002643 phosphorylation site [posttranslational modification] 337191002644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191002645 ATP binding site [chemical binding]; other site 337191002646 Mg2+ binding site [ion binding]; other site 337191002647 G-X-G motif; other site 337191002648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 337191002649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191002650 active site 337191002651 phosphorylation site [posttranslational modification] 337191002652 intermolecular recognition site; other site 337191002653 dimerization interface [polypeptide binding]; other site 337191002654 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191002655 DNA binding site [nucleotide binding] 337191002656 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 337191002657 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 337191002658 African swine fever virus J13L protein; Region: ASFV_J13L; pfam05568 337191002659 Putative integral membrane protein DUF46; Region: DUF46; cl17511 337191002660 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 337191002661 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 337191002662 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 337191002663 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 337191002664 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 337191002665 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 337191002666 DNA binding domain, excisionase family; Region: excise; TIGR01764 337191002667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191002668 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 337191002669 NAD(P) binding site [chemical binding]; other site 337191002670 active site 337191002671 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 337191002672 putative acyl-acceptor binding pocket; other site 337191002673 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 337191002674 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 337191002675 putative NAD(P) binding site [chemical binding]; other site 337191002676 catalytic Zn binding site [ion binding]; other site 337191002677 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191002678 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191002679 active site 337191002680 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 337191002681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191002682 motif II; other site 337191002683 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 337191002684 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 337191002685 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 337191002686 tRNA; other site 337191002687 putative tRNA binding site [nucleotide binding]; other site 337191002688 putative NADP binding site [chemical binding]; other site 337191002689 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 337191002690 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 337191002691 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 337191002692 domain interfaces; other site 337191002693 active site 337191002694 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 337191002695 active site 337191002696 homodimer interface [polypeptide binding]; other site 337191002697 SAM binding site [chemical binding]; other site 337191002698 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 337191002699 active site 337191002700 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 337191002701 dimer interface [polypeptide binding]; other site 337191002702 active site 337191002703 Schiff base residues; other site 337191002704 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 337191002705 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 337191002706 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 337191002707 dimanganese center [ion binding]; other site 337191002708 acyl-coenzyme A oxidase; Region: PLN02526 337191002709 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 337191002710 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191002711 active site 337191002712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191002713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191002714 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191002715 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 337191002716 FAD binding site [chemical binding]; other site 337191002717 homotetramer interface [polypeptide binding]; other site 337191002718 substrate binding pocket [chemical binding]; other site 337191002719 catalytic base [active] 337191002720 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 337191002721 putative active site [active] 337191002722 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 337191002723 tetramerization interface [polypeptide binding]; other site 337191002724 NAD(P) binding site [chemical binding]; other site 337191002725 catalytic residues [active] 337191002726 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 337191002727 active site 337191002728 catalytic triad [active] 337191002729 oxyanion hole [active] 337191002730 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 337191002731 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 337191002732 inhibitor-cofactor binding pocket; inhibition site 337191002733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191002734 catalytic residue [active] 337191002735 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 337191002736 catalytic core [active] 337191002737 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 337191002738 catalytic residues [active] 337191002739 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 337191002740 ResB-like family; Region: ResB; pfam05140 337191002741 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 337191002742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191002743 sequence-specific DNA binding site [nucleotide binding]; other site 337191002744 salt bridge; other site 337191002745 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 337191002746 cysteine synthase; Region: PLN02565 337191002747 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 337191002748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191002749 catalytic residue [active] 337191002750 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 337191002751 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 337191002752 Walker A/P-loop; other site 337191002753 ATP binding site [chemical binding]; other site 337191002754 Q-loop/lid; other site 337191002755 ABC transporter signature motif; other site 337191002756 Walker B; other site 337191002757 D-loop; other site 337191002758 H-loop/switch region; other site 337191002759 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 337191002760 FtsX-like permease family; Region: FtsX; pfam02687 337191002761 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 337191002762 FtsX-like permease family; Region: FtsX; pfam02687 337191002763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 337191002764 DNA binding residues [nucleotide binding] 337191002765 Clp amino terminal domain; Region: Clp_N; pfam02861 337191002766 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 337191002767 putative active site [active] 337191002768 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191002769 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 337191002770 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 337191002771 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191002772 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191002773 Condensation domain; Region: Condensation; cl19241 337191002774 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191002775 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191002776 active site 337191002777 CoA binding site [chemical binding]; other site 337191002778 AMP binding site [chemical binding]; other site 337191002779 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191002780 Condensation domain; Region: Condensation; cl19241 337191002781 peptide synthase; Provisional; Region: PRK12467 337191002782 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191002783 acyl-activating enzyme (AAE) consensus motif; other site 337191002784 AMP binding site [chemical binding]; other site 337191002785 Condensation domain; Region: Condensation; cl19241 337191002786 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191002787 acyl-activating enzyme (AAE) consensus motif; other site 337191002788 AMP binding site [chemical binding]; other site 337191002789 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191002790 Condensation domain; Region: Condensation; cl19241 337191002791 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191002792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191002793 Condensation domain; Region: Condensation; cl19241 337191002794 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191002795 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191002796 AMP binding site [chemical binding]; other site 337191002797 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191002798 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191002799 Low molecular weight phosphatase family; Region: LMWPc; cd00115 337191002800 active site 337191002801 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 337191002802 Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447 337191002803 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191002804 substrate binding site [chemical binding]; other site 337191002805 oxyanion hole (OAH) forming residues; other site 337191002806 trimer interface [polypeptide binding]; other site 337191002807 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191002808 CoenzymeA binding site [chemical binding]; other site 337191002809 subunit interaction site [polypeptide binding]; other site 337191002810 PHB binding site; other site 337191002811 hypothetical protein; Provisional; Region: PRK07877 337191002812 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 337191002813 ATP binding site [chemical binding]; other site 337191002814 substrate interface [chemical binding]; other site 337191002815 Nitroreductase family; Region: Nitroreductase; pfam00881 337191002816 dimer interface [polypeptide binding]; other site 337191002817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 337191002818 metal binding site [ion binding]; metal-binding site 337191002819 active site 337191002820 I-site; other site 337191002821 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 337191002822 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 337191002823 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 337191002824 putative dimer interface [polypeptide binding]; other site 337191002825 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 337191002826 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 337191002827 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 337191002828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191002829 S-adenosylmethionine binding site [chemical binding]; other site 337191002830 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 337191002831 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 337191002832 dimer interface [polypeptide binding]; other site 337191002833 tetramer interface [polypeptide binding]; other site 337191002834 PYR/PP interface [polypeptide binding]; other site 337191002835 TPP binding site [chemical binding]; other site 337191002836 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 337191002837 TPP-binding site; other site 337191002838 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 337191002839 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 337191002840 catalytic triad [active] 337191002841 active site nucleophile [active] 337191002842 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191002843 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 337191002844 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 337191002845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191002846 S-adenosylmethionine binding site [chemical binding]; other site 337191002847 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 337191002848 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 337191002849 substrate binding pocket [chemical binding]; other site 337191002850 chain length determination region; other site 337191002851 substrate-Mg2+ binding site; other site 337191002852 catalytic residues [active] 337191002853 aspartate-rich region 1; other site 337191002854 active site lid residues [active] 337191002855 aspartate-rich region 2; other site 337191002856 heat shock protein HtpX; Provisional; Region: PRK03072 337191002857 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 337191002858 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 337191002859 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 337191002860 active site 337191002861 catalytic site [active] 337191002862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191002863 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191002864 active site 2 [active] 337191002865 active site 1 [active] 337191002866 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 337191002867 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 337191002868 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 337191002869 putative homodimer interface [polypeptide binding]; other site 337191002870 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 337191002871 heterodimer interface [polypeptide binding]; other site 337191002872 homodimer interface [polypeptide binding]; other site 337191002873 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 337191002874 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 337191002875 23S rRNA interface [nucleotide binding]; other site 337191002876 L7/L12 interface [polypeptide binding]; other site 337191002877 putative thiostrepton binding site; other site 337191002878 L25 interface [polypeptide binding]; other site 337191002879 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 337191002880 mRNA/rRNA interface [nucleotide binding]; other site 337191002881 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191002882 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191002883 active site 337191002884 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 337191002885 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 337191002886 intersubunit interface [polypeptide binding]; other site 337191002887 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 337191002888 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 337191002889 Walker A/P-loop; other site 337191002890 ATP binding site [chemical binding]; other site 337191002891 Q-loop/lid; other site 337191002892 ABC transporter signature motif; other site 337191002893 Walker B; other site 337191002894 D-loop; other site 337191002895 H-loop/switch region; other site 337191002896 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 337191002897 ABC-ATPase subunit interface; other site 337191002898 dimer interface [polypeptide binding]; other site 337191002899 putative PBP binding regions; other site 337191002900 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 337191002901 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 337191002902 NAD binding site [chemical binding]; other site 337191002903 dimer interface [polypeptide binding]; other site 337191002904 substrate binding site [chemical binding]; other site 337191002905 tetramer (dimer of dimers) interface [polypeptide binding]; other site 337191002906 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191002907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191002908 Helix-turn-helix domain; Region: HTH_18; pfam12833 337191002909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191002910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 337191002911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191002912 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 337191002913 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 337191002914 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 337191002915 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 337191002916 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 337191002917 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 337191002918 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 337191002919 Na binding site [ion binding]; other site 337191002920 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 337191002921 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 337191002922 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 337191002923 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 337191002924 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 337191002925 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 337191002926 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 337191002927 ligand binding site [chemical binding]; other site 337191002928 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 337191002929 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191002930 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 337191002931 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 337191002932 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 337191002933 23S rRNA interface [nucleotide binding]; other site 337191002934 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 337191002935 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 337191002936 core dimer interface [polypeptide binding]; other site 337191002937 peripheral dimer interface [polypeptide binding]; other site 337191002938 L10 interface [polypeptide binding]; other site 337191002939 L11 interface [polypeptide binding]; other site 337191002940 putative EF-Tu interaction site [polypeptide binding]; other site 337191002941 putative EF-G interaction site [polypeptide binding]; other site 337191002942 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191002943 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 337191002944 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 337191002945 Walker A/P-loop; other site 337191002946 ATP binding site [chemical binding]; other site 337191002947 Q-loop/lid; other site 337191002948 ABC transporter signature motif; other site 337191002949 Walker B; other site 337191002950 D-loop; other site 337191002951 H-loop/switch region; other site 337191002952 Permease; Region: Permease; pfam02405 337191002953 Permease; Region: Permease; pfam02405 337191002954 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191002955 mce related protein; Region: MCE; pfam02470 337191002956 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 337191002957 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191002958 mce related protein; Region: MCE; pfam02470 337191002959 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 337191002960 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191002961 mce related protein; Region: MCE; pfam02470 337191002962 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 337191002963 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191002964 mce related protein; Region: MCE; pfam02470 337191002965 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 337191002966 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191002967 mce related protein; Region: MCE; pfam02470 337191002968 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 337191002969 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191002970 mce related protein; Region: MCE; pfam02470 337191002971 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 337191002972 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 337191002973 RPB12 interaction site [polypeptide binding]; other site 337191002974 RPB1 interaction site [polypeptide binding]; other site 337191002975 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 337191002976 RPB10 interaction site [polypeptide binding]; other site 337191002977 RPB11 interaction site [polypeptide binding]; other site 337191002978 RPB3 interaction site [polypeptide binding]; other site 337191002979 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 337191002980 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 337191002981 beta and beta' interface [polypeptide binding]; other site 337191002982 beta' and sigma factor interface [polypeptide binding]; other site 337191002983 Zn-binding [ion binding]; other site 337191002984 active site region [active] 337191002985 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 337191002986 catalytic site [active] 337191002987 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 337191002988 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 337191002989 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 337191002990 G-loop; other site 337191002991 DNA binding site [nucleotide binding] 337191002992 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 337191002993 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 337191002994 acyl-activating enzyme (AAE) consensus motif; other site 337191002995 putative AMP binding site [chemical binding]; other site 337191002996 putative active site [active] 337191002997 putative CoA binding site [chemical binding]; other site 337191002998 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 337191002999 classical (c) SDRs; Region: SDR_c; cd05233 337191003000 NAD(P) binding site [chemical binding]; other site 337191003001 active site 337191003002 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 337191003003 DinB superfamily; Region: DinB_2; cl19195 337191003004 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 337191003005 NAD binding site [chemical binding]; other site 337191003006 catalytic residues [active] 337191003007 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 337191003008 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 337191003009 glutaminase; Provisional; Region: PRK00971 337191003010 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 337191003011 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 337191003012 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 337191003013 Divergent AAA domain; Region: AAA_4; pfam04326 337191003014 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 337191003015 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191003016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191003017 DNA binding residues [nucleotide binding] 337191003018 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 337191003019 G4 box; other site 337191003020 GTP/Mg2+ binding site [chemical binding]; other site 337191003021 G5 box; other site 337191003022 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 337191003023 G1 box; other site 337191003024 G1 box; other site 337191003025 GTP/Mg2+ binding site [chemical binding]; other site 337191003026 G2 box; other site 337191003027 Switch I region; other site 337191003028 G3 box; other site 337191003029 Switch II region; other site 337191003030 G4 box; other site 337191003031 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 337191003032 G1 box; other site 337191003033 GTP/Mg2+ binding site [chemical binding]; other site 337191003034 G2 box; other site 337191003035 Switch I region; other site 337191003036 G3 box; other site 337191003037 Switch II region; other site 337191003038 G4 box; other site 337191003039 G5 box; other site 337191003040 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 337191003041 nucleotide binding site [chemical binding]; other site 337191003042 putative NEF/HSP70 interaction site [polypeptide binding]; other site 337191003043 SBD interface [polypeptide binding]; other site 337191003044 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 337191003045 lipoyl-biotinyl attachment site [posttranslational modification]; other site 337191003046 DNA polymerase IV; Validated; Region: PRK03352 337191003047 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 337191003048 active site 337191003049 DNA binding site [nucleotide binding] 337191003050 Sulfatase; Region: Sulfatase; cl19157 337191003051 Uncharacterized conserved protein [Function unknown]; Region: COG3375 337191003052 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 337191003053 CopC domain; Region: CopC; pfam04234 337191003054 Copper resistance protein D; Region: CopD; cl00563 337191003055 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191003056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191003057 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 337191003058 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191003059 Transposase; Region: HTH_Tnp_1; cl17663 337191003060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 337191003061 putative transposase OrfB; Reviewed; Region: PHA02517 337191003062 HTH-like domain; Region: HTH_21; pfam13276 337191003063 Integrase core domain; Region: rve; pfam00665 337191003064 Integrase core domain; Region: rve_3; pfam13683 337191003065 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 337191003066 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 337191003067 DXD motif; other site 337191003068 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 337191003069 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 337191003070 Acyltransferase family; Region: Acyl_transf_3; pfam01757 337191003071 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 337191003072 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 337191003073 substrate binding site; other site 337191003074 tetramer interface; other site 337191003075 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 337191003076 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 337191003077 NAD binding site [chemical binding]; other site 337191003078 substrate binding site [chemical binding]; other site 337191003079 homodimer interface [polypeptide binding]; other site 337191003080 active site 337191003081 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 337191003082 CoA binding domain; Region: CoA_binding; cl17356 337191003083 Bacterial sugar transferase; Region: Bac_transf; pfam02397 337191003084 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 337191003085 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 337191003086 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 337191003087 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 337191003088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 337191003089 active site 337191003090 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 337191003091 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 337191003092 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 337191003093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 337191003094 active site 337191003095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191003096 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191003097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191003098 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191003099 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191003100 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191003101 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191003102 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 337191003103 Chain length determinant protein; Region: Wzz; pfam02706 337191003104 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 337191003105 AAA domain; Region: AAA_31; pfam13614 337191003106 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 337191003107 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 337191003108 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 337191003109 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 337191003110 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 337191003111 Acyltransferase family; Region: Acyl_transf_3; pfam01757 337191003112 Chain length determinant protein; Region: Wzz; pfam02706 337191003113 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 337191003114 putative trimer interface [polypeptide binding]; other site 337191003115 putative CoA binding site [chemical binding]; other site 337191003116 Chain length determinant protein; Region: Wzz; pfam02706 337191003117 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; cl10513 337191003118 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 337191003119 active site 337191003120 catalytic triad [active] 337191003121 oxyanion hole [active] 337191003122 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 337191003123 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191003124 active site 337191003125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191003126 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 337191003127 putative ADP-binding pocket [chemical binding]; other site 337191003128 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 337191003129 putative trimer interface [polypeptide binding]; other site 337191003130 putative CoA binding site [chemical binding]; other site 337191003131 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 337191003132 putative glycosyl transferase; Provisional; Region: PRK10307 337191003133 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 337191003134 putative trimer interface [polypeptide binding]; other site 337191003135 putative CoA binding site [chemical binding]; other site 337191003136 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 337191003137 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 337191003138 NADP binding site [chemical binding]; other site 337191003139 active site 337191003140 putative substrate binding site [chemical binding]; other site 337191003141 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 337191003142 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 337191003143 NADP-binding site; other site 337191003144 homotetramer interface [polypeptide binding]; other site 337191003145 substrate binding site [chemical binding]; other site 337191003146 homodimer interface [polypeptide binding]; other site 337191003147 active site 337191003148 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 337191003149 CoA binding domain; Region: CoA_binding; cl17356 337191003150 Bacterial sugar transferase; Region: Bac_transf; pfam02397 337191003151 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 337191003152 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 337191003153 active site 337191003154 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191003155 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191003156 active site 337191003157 PE-PPE domain; Region: PE-PPE; pfam08237 337191003158 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 337191003159 putative active site [active] 337191003160 putative CoA binding site [chemical binding]; other site 337191003161 nudix motif; other site 337191003162 metal binding site [ion binding]; metal-binding site 337191003163 Uncharacterized conserved protein [Function unknown]; Region: COG2353 337191003164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 337191003165 dimerization interface [polypeptide binding]; other site 337191003166 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 337191003167 cyclase homology domain; Region: CHD; cd07302 337191003168 nucleotidyl binding site; other site 337191003169 metal binding site [ion binding]; metal-binding site 337191003170 dimer interface [polypeptide binding]; other site 337191003171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191003172 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 337191003173 NAD(P) binding site [chemical binding]; other site 337191003174 active site 337191003175 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 337191003176 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 337191003177 GIY-YIG motif/motif A; other site 337191003178 putative active site [active] 337191003179 putative metal binding site [ion binding]; other site 337191003180 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 337191003181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191003182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191003183 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 337191003184 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191003185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191003186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191003187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191003188 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191003189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191003190 NAD(P) binding site [chemical binding]; other site 337191003191 active site 337191003192 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 337191003193 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 337191003194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191003195 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191003196 putative substrate translocation pore; other site 337191003197 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 337191003198 TPP-binding site [chemical binding]; other site 337191003199 dimer interface [polypeptide binding]; other site 337191003200 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 337191003201 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 337191003202 PYR/PP interface [polypeptide binding]; other site 337191003203 dimer interface [polypeptide binding]; other site 337191003204 TPP binding site [chemical binding]; other site 337191003205 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 337191003206 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191003207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191003208 DNA-binding site [nucleotide binding]; DNA binding site 337191003209 FCD domain; Region: FCD; pfam07729 337191003210 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 337191003211 aminotransferase; Validated; Region: PRK07777 337191003212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191003213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191003214 homodimer interface [polypeptide binding]; other site 337191003215 catalytic residue [active] 337191003216 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191003217 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191003218 active site 337191003219 ATP binding site [chemical binding]; other site 337191003220 substrate binding site [chemical binding]; other site 337191003221 activation loop (A-loop); other site 337191003222 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 337191003223 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 337191003224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191003225 ATP binding site [chemical binding]; other site 337191003226 putative Mg++ binding site [ion binding]; other site 337191003227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191003228 nucleotide binding region [chemical binding]; other site 337191003229 ATP-binding site [chemical binding]; other site 337191003230 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 337191003231 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 337191003232 WYL domain; Region: WYL; cl14852 337191003233 allantoinase; Region: allantoinase; TIGR03178 337191003234 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191003235 active site 337191003236 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 337191003237 Na binding site [ion binding]; other site 337191003238 putative substrate binding site [chemical binding]; other site 337191003239 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 337191003240 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 337191003241 TIGR03086 family protein; Region: TIGR03086 337191003242 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191003243 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191003244 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 337191003245 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 337191003246 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 337191003247 anti sigma factor interaction site; other site 337191003248 regulatory phosphorylation site [posttranslational modification]; other site 337191003249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191003250 dimerization interface [polypeptide binding]; other site 337191003251 putative DNA binding site [nucleotide binding]; other site 337191003252 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191003253 putative Zn2+ binding site [ion binding]; other site 337191003254 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191003255 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191003256 active site 337191003257 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 337191003258 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 337191003259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191003260 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191003261 putative substrate translocation pore; other site 337191003262 HAMP domain; Region: HAMP; pfam00672 337191003263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 337191003264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191003265 dimer interface [polypeptide binding]; other site 337191003266 phosphorylation site [posttranslational modification] 337191003267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191003268 ATP binding site [chemical binding]; other site 337191003269 Mg2+ binding site [ion binding]; other site 337191003270 G-X-G motif; other site 337191003271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 337191003272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191003273 active site 337191003274 phosphorylation site [posttranslational modification] 337191003275 intermolecular recognition site; other site 337191003276 dimerization interface [polypeptide binding]; other site 337191003277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191003278 DNA binding site [nucleotide binding] 337191003279 hypothetical protein; Provisional; Region: PRK11171 337191003280 Cupin domain; Region: Cupin_2; pfam07883 337191003281 Cupin domain; Region: Cupin_2; cl17218 337191003282 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 337191003283 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 337191003284 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191003285 Bacterial transcriptional regulator; Region: IclR; pfam01614 337191003286 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191003287 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191003288 active site 337191003289 ATP binding site [chemical binding]; other site 337191003290 substrate binding site [chemical binding]; other site 337191003291 activation loop (A-loop); other site 337191003292 Proline-rich; Region: Pro-rich; pfam15240 337191003293 YppG-like protein; Region: YppG; pfam14179 337191003294 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003295 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 337191003296 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003297 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003298 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 337191003299 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003300 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003301 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 337191003302 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191003303 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191003304 active site 337191003305 ATP binding site [chemical binding]; other site 337191003306 substrate binding site [chemical binding]; other site 337191003307 activation loop (A-loop); other site 337191003308 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003309 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003310 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003311 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003312 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003313 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003314 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191003315 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 337191003316 trimer interface [polypeptide binding]; other site 337191003317 dimer interface [polypeptide binding]; other site 337191003318 putative active site [active] 337191003319 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 337191003320 MPT binding site; other site 337191003321 trimer interface [polypeptide binding]; other site 337191003322 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 337191003323 MoaE homodimer interface [polypeptide binding]; other site 337191003324 MoaD interaction [polypeptide binding]; other site 337191003325 active site residues [active] 337191003326 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 337191003327 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 337191003328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191003329 FeS/SAM binding site; other site 337191003330 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 337191003331 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 337191003332 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 337191003333 DNA-binding site [nucleotide binding]; DNA binding site 337191003334 RNA-binding motif; other site 337191003335 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 337191003336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191003337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191003338 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 337191003339 heat shock protein 90; Provisional; Region: PRK05218 337191003340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191003341 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 337191003342 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191003343 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191003344 active site 337191003345 Hemerythrin-like domain; Region: Hr-like; cd12108 337191003346 Fe binding site [ion binding]; other site 337191003347 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 337191003348 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 337191003349 active site 337191003350 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 337191003351 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191003352 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191003353 active site 337191003354 Phosphotransferase enzyme family; Region: APH; pfam01636 337191003355 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 337191003356 putative active site [active] 337191003357 putative substrate binding site [chemical binding]; other site 337191003358 ATP binding site [chemical binding]; other site 337191003359 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 337191003360 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 337191003361 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 337191003362 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 337191003363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191003364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191003365 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 337191003366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191003367 dimer interface [polypeptide binding]; other site 337191003368 conserved gate region; other site 337191003369 putative PBP binding loops; other site 337191003370 ABC-ATPase subunit interface; other site 337191003371 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 337191003372 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 337191003373 Walker A/P-loop; other site 337191003374 ATP binding site [chemical binding]; other site 337191003375 Q-loop/lid; other site 337191003376 ABC transporter signature motif; other site 337191003377 Walker B; other site 337191003378 D-loop; other site 337191003379 H-loop/switch region; other site 337191003380 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 337191003381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 337191003382 substrate binding pocket [chemical binding]; other site 337191003383 membrane-bound complex binding site; other site 337191003384 hinge residues; other site 337191003385 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 337191003386 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 337191003387 Sulfate transporter family; Region: Sulfate_transp; cl19250 337191003388 Sulfate transporter family; Region: Sulfate_transp; cl19250 337191003389 hypothetical protein; Provisional; Region: PRK01346 337191003390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191003391 Coenzyme A binding pocket [chemical binding]; other site 337191003392 Sterol carrier protein domain; Region: SCP2_2; pfam13530 337191003393 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 337191003394 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 337191003395 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 337191003396 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 337191003397 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191003398 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191003399 catalytic residue [active] 337191003400 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 337191003401 citrate synthase 2; Provisional; Region: PRK12350 337191003402 oxalacetate binding site [chemical binding]; other site 337191003403 citrylCoA binding site [chemical binding]; other site 337191003404 coenzyme A binding site [chemical binding]; other site 337191003405 catalytic triad [active] 337191003406 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 337191003407 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 337191003408 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 337191003409 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 337191003410 enterobactin exporter EntS; Provisional; Region: PRK10489 337191003411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191003412 putative substrate translocation pore; other site 337191003413 oxidase reductase; Provisional; Region: PTZ00273 337191003414 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 337191003415 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 337191003416 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 337191003417 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 337191003418 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 337191003419 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 337191003420 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 337191003421 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 337191003422 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 337191003423 putative substrate binding site [chemical binding]; other site 337191003424 putative ATP binding site [chemical binding]; other site 337191003425 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 337191003426 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 337191003427 dimer interface [polypeptide binding]; other site 337191003428 active site 337191003429 citrylCoA binding site [chemical binding]; other site 337191003430 NADH binding [chemical binding]; other site 337191003431 cationic pore residues; other site 337191003432 oxalacetate/citrate binding site [chemical binding]; other site 337191003433 coenzyme A binding site [chemical binding]; other site 337191003434 catalytic triad [active] 337191003435 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 337191003436 DNA photolyase; Region: DNA_photolyase; pfam00875 337191003437 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 337191003438 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 337191003439 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191003440 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191003441 active site 337191003442 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 337191003443 Acyltransferase family; Region: Acyl_transf_3; cl19154 337191003444 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 337191003445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191003446 Walker A/P-loop; other site 337191003447 ATP binding site [chemical binding]; other site 337191003448 Q-loop/lid; other site 337191003449 ABC transporter signature motif; other site 337191003450 Walker B; other site 337191003451 D-loop; other site 337191003452 H-loop/switch region; other site 337191003453 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 337191003454 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 337191003455 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191003456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191003457 salt bridge; other site 337191003458 non-specific DNA binding site [nucleotide binding]; other site 337191003459 sequence-specific DNA binding site [nucleotide binding]; other site 337191003460 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191003461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191003462 enoyl-CoA hydratase; Provisional; Region: PRK07854 337191003463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191003464 substrate binding site [chemical binding]; other site 337191003465 oxyanion hole (OAH) forming residues; other site 337191003466 trimer interface [polypeptide binding]; other site 337191003467 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 337191003468 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 337191003469 XdhC Rossmann domain; Region: XdhC_C; pfam13478 337191003470 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191003471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191003472 dimerization interface [polypeptide binding]; other site 337191003473 putative Zn2+ binding site [ion binding]; other site 337191003474 putative DNA binding site [nucleotide binding]; other site 337191003475 Bacterial transcriptional regulator; Region: IclR; pfam01614 337191003476 BCCT family transporter; Region: BCCT; pfam02028 337191003477 FAD dependent oxidoreductase; Region: DAO; pfam01266 337191003478 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191003479 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 337191003480 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 337191003481 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 337191003482 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 337191003483 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 337191003484 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 337191003485 putative active site [active] 337191003486 putative substrate binding site [chemical binding]; other site 337191003487 putative cosubstrate binding site; other site 337191003488 catalytic site [active] 337191003489 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 337191003490 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 337191003491 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 337191003492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191003493 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 337191003494 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 337191003495 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 337191003496 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 337191003497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191003498 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191003499 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 337191003500 FAD binding pocket [chemical binding]; other site 337191003501 FAD binding motif [chemical binding]; other site 337191003502 phosphate binding motif [ion binding]; other site 337191003503 beta-alpha-beta structure motif; other site 337191003504 NAD binding pocket [chemical binding]; other site 337191003505 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191003506 catalytic loop [active] 337191003507 iron binding site [ion binding]; other site 337191003508 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 337191003509 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 337191003510 [2Fe-2S] cluster binding site [ion binding]; other site 337191003511 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 337191003512 putative alpha subunit interface [polypeptide binding]; other site 337191003513 putative active site [active] 337191003514 putative substrate binding site [chemical binding]; other site 337191003515 Fe binding site [ion binding]; other site 337191003516 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 337191003517 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 337191003518 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 337191003519 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191003520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191003521 DNA-binding site [nucleotide binding]; DNA binding site 337191003522 FCD domain; Region: FCD; pfam07729 337191003523 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 337191003524 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 337191003525 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 337191003526 Walker A/P-loop; other site 337191003527 ATP binding site [chemical binding]; other site 337191003528 Q-loop/lid; other site 337191003529 ABC transporter signature motif; other site 337191003530 Walker B; other site 337191003531 D-loop; other site 337191003532 H-loop/switch region; other site 337191003533 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 337191003534 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 337191003535 TM-ABC transporter signature motif; other site 337191003536 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 337191003537 TM-ABC transporter signature motif; other site 337191003538 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 337191003539 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 337191003540 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 337191003541 nucleoside/Zn binding site; other site 337191003542 dimer interface [polypeptide binding]; other site 337191003543 catalytic motif [active] 337191003544 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 337191003545 FAD binding domain; Region: FAD_binding_4; pfam01565 337191003546 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 337191003547 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 337191003548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 337191003549 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 337191003550 catalytic residue [active] 337191003551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 337191003552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191003553 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 337191003554 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 337191003555 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 337191003556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191003557 motif I; other site 337191003558 motif II; other site 337191003559 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 337191003560 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 337191003561 active site 337191003562 DNA binding site [nucleotide binding] 337191003563 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 337191003564 hydrophobic ligand binding site; other site 337191003565 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 337191003566 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 337191003567 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 337191003568 metal ion-dependent adhesion site (MIDAS); other site 337191003569 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 337191003570 ApbE family; Region: ApbE; pfam02424 337191003571 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 337191003572 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 337191003573 FAD binding pocket [chemical binding]; other site 337191003574 conserved FAD binding motif [chemical binding]; other site 337191003575 phosphate binding motif [ion binding]; other site 337191003576 beta-alpha-beta structure motif; other site 337191003577 NAD binding pocket [chemical binding]; other site 337191003578 Proline dehydrogenase; Region: Pro_dh; pfam01619 337191003579 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 337191003580 NAD(P) binding site [chemical binding]; other site 337191003581 catalytic residues [active] 337191003582 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 337191003583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191003584 NAD(P) binding site [chemical binding]; other site 337191003585 active site 337191003586 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191003587 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 337191003588 DNA binding residues [nucleotide binding] 337191003589 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 337191003590 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 337191003591 Sulfate transporter family; Region: Sulfate_transp; pfam00916 337191003592 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 337191003593 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 337191003594 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 337191003595 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 337191003596 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 337191003597 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 337191003598 hydrophobic ligand binding site; other site 337191003599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191003600 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191003601 putative substrate translocation pore; other site 337191003602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191003603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191003604 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 337191003605 Acyltransferase family; Region: Acyl_transf_3; pfam01757 337191003606 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 337191003607 AAA ATPase domain; Region: AAA_16; pfam13191 337191003608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191003609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191003610 DNA binding residues [nucleotide binding] 337191003611 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 337191003612 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 337191003613 conserved cys residue [active] 337191003614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191003615 short chain dehydrogenase; Provisional; Region: PRK06179 337191003616 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 337191003617 NADP binding site [chemical binding]; other site 337191003618 active site 337191003619 steroid binding site; other site 337191003620 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 337191003621 active site 337191003622 SAM binding site [chemical binding]; other site 337191003623 homodimer interface [polypeptide binding]; other site 337191003624 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 337191003625 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 337191003626 active site 337191003627 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 337191003628 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 337191003629 DNA binding site [nucleotide binding] 337191003630 catalytic residue [active] 337191003631 H2TH interface [polypeptide binding]; other site 337191003632 putative catalytic residues [active] 337191003633 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 337191003634 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 337191003635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191003636 short chain dehydrogenase; Region: adh_short; pfam00106 337191003637 NAD(P) binding site [chemical binding]; other site 337191003638 active site 337191003639 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 337191003640 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 337191003641 active site 337191003642 dimer interface [polypeptide binding]; other site 337191003643 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 337191003644 dimer interface [polypeptide binding]; other site 337191003645 active site 337191003646 Chorismate mutase type II; Region: CM_2; cl00693 337191003647 Restriction endonuclease fold toxin 5; Region: Tox-REase-5; pfam15648 337191003648 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 337191003649 Part of AAA domain; Region: AAA_19; pfam13245 337191003650 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 337191003651 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 337191003652 Peptidase family M23; Region: Peptidase_M23; pfam01551 337191003653 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 337191003654 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 337191003655 CoA-ligase; Region: Ligase_CoA; pfam00549 337191003656 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 337191003657 CoA binding domain; Region: CoA_binding; smart00881 337191003658 CoA-ligase; Region: Ligase_CoA; pfam00549 337191003659 RDD family; Region: RDD; pfam06271 337191003660 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 337191003661 putative hydrophobic ligand binding site [chemical binding]; other site 337191003662 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 337191003663 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 337191003664 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 337191003665 nudix motif; other site 337191003666 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 337191003667 FMN binding site [chemical binding]; other site 337191003668 dimer interface [polypeptide binding]; other site 337191003669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191003670 EBNA-3C; Provisional; Region: PHA03377 337191003671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 337191003672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 337191003673 active site 337191003674 catalytic tetrad [active] 337191003675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191003676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191003677 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 337191003678 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 337191003679 Walker A/P-loop; other site 337191003680 ATP binding site [chemical binding]; other site 337191003681 Q-loop/lid; other site 337191003682 ABC transporter signature motif; other site 337191003683 Walker B; other site 337191003684 D-loop; other site 337191003685 H-loop/switch region; other site 337191003686 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 337191003687 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 337191003688 TM-ABC transporter signature motif; other site 337191003689 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 337191003690 [2Fe-2S] cluster binding site [ion binding]; other site 337191003691 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 337191003692 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 337191003693 ligand binding site [chemical binding]; other site 337191003694 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191003695 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191003696 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 337191003697 iron-sulfur cluster [ion binding]; other site 337191003698 [2Fe-2S] cluster binding site [ion binding]; other site 337191003699 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 337191003700 beta subunit interface [polypeptide binding]; other site 337191003701 alpha subunit interface [polypeptide binding]; other site 337191003702 active site 337191003703 substrate binding site [chemical binding]; other site 337191003704 Fe binding site [ion binding]; other site 337191003705 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 337191003706 inter-subunit interface; other site 337191003707 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 337191003708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191003709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191003710 Reductase C-terminal; Region: Reductase_C; pfam14759 337191003711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191003712 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191003713 GAF domain; Region: GAF_2; pfam13185 337191003714 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191003715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191003716 DNA binding residues [nucleotide binding] 337191003717 dimerization interface [polypeptide binding]; other site 337191003718 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 337191003719 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 337191003720 dimer interface [polypeptide binding]; other site 337191003721 PYR/PP interface [polypeptide binding]; other site 337191003722 TPP binding site [chemical binding]; other site 337191003723 substrate binding site [chemical binding]; other site 337191003724 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 337191003725 TPP-binding site; other site 337191003726 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 337191003727 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 337191003728 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 337191003729 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 337191003730 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 337191003731 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 337191003732 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 337191003733 ATP-grasp domain; Region: ATP-grasp_4; cl17255 337191003734 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 337191003735 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 337191003736 carboxyltransferase (CT) interaction site; other site 337191003737 biotinylation site [posttranslational modification]; other site 337191003738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191003739 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191003740 active site 337191003741 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 337191003742 putative active site [active] 337191003743 putative catalytic site [active] 337191003744 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 337191003745 AMP-binding domain protein; Validated; Region: PRK08315 337191003746 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 337191003747 acyl-activating enzyme (AAE) consensus motif; other site 337191003748 putative AMP binding site [chemical binding]; other site 337191003749 putative active site [active] 337191003750 putative CoA binding site [chemical binding]; other site 337191003751 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 337191003752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191003753 acyl-activating enzyme (AAE) consensus motif; other site 337191003754 AMP binding site [chemical binding]; other site 337191003755 active site 337191003756 CoA binding site [chemical binding]; other site 337191003757 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 337191003758 HB1, ASXL, restriction endonuclease HTH domain; Region: HARE-HTH; cl01319 337191003759 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 337191003760 active site 337191003761 substrate binding site [chemical binding]; other site 337191003762 cosubstrate binding site; other site 337191003763 catalytic site [active] 337191003764 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 337191003765 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 337191003766 purine monophosphate binding site [chemical binding]; other site 337191003767 dimer interface [polypeptide binding]; other site 337191003768 putative catalytic residues [active] 337191003769 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 337191003770 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 337191003771 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191003772 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191003773 active site 337191003774 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 337191003775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191003776 dimer interface [polypeptide binding]; other site 337191003777 conserved gate region; other site 337191003778 putative PBP binding loops; other site 337191003779 ABC-ATPase subunit interface; other site 337191003780 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 337191003781 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 337191003782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 337191003783 substrate binding pocket [chemical binding]; other site 337191003784 membrane-bound complex binding site; other site 337191003785 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 337191003786 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 337191003787 Walker A/P-loop; other site 337191003788 ATP binding site [chemical binding]; other site 337191003789 Q-loop/lid; other site 337191003790 ABC transporter signature motif; other site 337191003791 Walker B; other site 337191003792 D-loop; other site 337191003793 H-loop/switch region; other site 337191003794 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 337191003795 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 337191003796 substrate binding pocket [chemical binding]; other site 337191003797 active site 337191003798 iron coordination sites [ion binding]; other site 337191003799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191003800 dimerization interface [polypeptide binding]; other site 337191003801 putative DNA binding site [nucleotide binding]; other site 337191003802 putative Zn2+ binding site [ion binding]; other site 337191003803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191003804 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191003805 hydrophobic ligand binding site; other site 337191003806 TIGR03086 family protein; Region: TIGR03086 337191003807 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 337191003808 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 337191003809 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 337191003810 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 337191003811 metal ion-dependent adhesion site (MIDAS); other site 337191003812 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 337191003813 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 337191003814 Predicted permeases [General function prediction only]; Region: COG0679 337191003815 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 337191003816 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 337191003817 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 337191003818 Predicted membrane protein [Function unknown]; Region: COG2860 337191003819 UPF0126 domain; Region: UPF0126; pfam03458 337191003820 UPF0126 domain; Region: UPF0126; pfam03458 337191003821 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191003822 short chain dehydrogenase; Provisional; Region: PRK08267 337191003823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191003824 NAD(P) binding site [chemical binding]; other site 337191003825 active site 337191003826 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 337191003827 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 337191003828 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 337191003829 4Fe-4S binding domain; Region: Fer4; pfam00037 337191003830 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 337191003831 ferredoxin-NADP+ reductase; Region: PLN02852 337191003832 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 337191003833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191003834 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 337191003835 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 337191003836 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 337191003837 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 337191003838 iron-sulfur cluster [ion binding]; other site 337191003839 [2Fe-2S] cluster binding site [ion binding]; other site 337191003840 GIY-YIG motif/motif A; other site 337191003841 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 337191003842 active site 337191003843 catalytic site [active] 337191003844 metal binding site [ion binding]; metal-binding site 337191003845 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 337191003846 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 337191003847 [4Fe-4S] binding site [ion binding]; other site 337191003848 molybdopterin cofactor binding site; other site 337191003849 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 337191003850 molybdopterin cofactor binding site; other site 337191003851 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 337191003852 Flavodoxin; Region: Flavodoxin_1; pfam00258 337191003853 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 337191003854 FAD binding pocket [chemical binding]; other site 337191003855 FAD binding motif [chemical binding]; other site 337191003856 catalytic residues [active] 337191003857 NAD binding pocket [chemical binding]; other site 337191003858 phosphate binding motif [ion binding]; other site 337191003859 beta-alpha-beta structure motif; other site 337191003860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 337191003861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191003862 active site 337191003863 phosphorylation site [posttranslational modification] 337191003864 intermolecular recognition site; other site 337191003865 dimerization interface [polypeptide binding]; other site 337191003866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191003867 DNA binding site [nucleotide binding] 337191003868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 337191003869 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 337191003870 dimerization interface [polypeptide binding]; other site 337191003871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191003872 dimer interface [polypeptide binding]; other site 337191003873 phosphorylation site [posttranslational modification] 337191003874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191003875 ATP binding site [chemical binding]; other site 337191003876 Mg2+ binding site [ion binding]; other site 337191003877 G-X-G motif; other site 337191003878 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 337191003879 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 337191003880 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 337191003881 protein binding site [polypeptide binding]; other site 337191003882 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 337191003883 MPT binding site; other site 337191003884 MspA; Region: MspA; pfam09203 337191003885 MspA; Region: MspA; pfam09203 337191003886 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191003887 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191003888 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 337191003889 Walker A/P-loop; other site 337191003890 ATP binding site [chemical binding]; other site 337191003891 Q-loop/lid; other site 337191003892 ABC transporter signature motif; other site 337191003893 Walker B; other site 337191003894 D-loop; other site 337191003895 H-loop/switch region; other site 337191003896 Putative esterase; Region: Esterase; pfam00756 337191003897 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191003898 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191003899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191003900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191003901 Walker A/P-loop; other site 337191003902 ATP binding site [chemical binding]; other site 337191003903 Q-loop/lid; other site 337191003904 ABC transporter signature motif; other site 337191003905 Walker B; other site 337191003906 D-loop; other site 337191003907 H-loop/switch region; other site 337191003908 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191003909 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191003910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191003911 Walker A/P-loop; other site 337191003912 ATP binding site [chemical binding]; other site 337191003913 Q-loop/lid; other site 337191003914 ABC transporter signature motif; other site 337191003915 Walker B; other site 337191003916 D-loop; other site 337191003917 H-loop/switch region; other site 337191003918 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 337191003919 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 337191003920 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 337191003921 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 337191003922 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 337191003923 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 337191003924 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 337191003925 active site 337191003926 tetramer interface; other site 337191003927 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 337191003928 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 337191003929 dimer interface [polypeptide binding]; other site 337191003930 putative functional site; other site 337191003931 putative MPT binding site; other site 337191003932 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 337191003933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191003934 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 337191003935 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 337191003936 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 337191003937 active site 337191003938 catalytic residues [active] 337191003939 DNA binding site [nucleotide binding] 337191003940 Int/Topo IB signature motif; other site 337191003941 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 337191003942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191003943 non-specific DNA binding site [nucleotide binding]; other site 337191003944 salt bridge; other site 337191003945 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191003946 sequence-specific DNA binding site [nucleotide binding]; other site 337191003947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191003948 non-specific DNA binding site [nucleotide binding]; other site 337191003949 salt bridge; other site 337191003950 sequence-specific DNA binding site [nucleotide binding]; other site 337191003951 BRO family, N-terminal domain; Region: Bro-N; pfam02498 337191003952 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 337191003953 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 337191003954 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 337191003955 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 337191003956 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 337191003957 cofactor binding site; other site 337191003958 DNA binding site [nucleotide binding] 337191003959 substrate interaction site [chemical binding]; other site 337191003960 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 337191003961 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 337191003962 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 337191003963 Protein of unknown function (DUF935); Region: DUF935; cl19863 337191003964 Mu-like prophage I protein; Region: Mu-like_Pro; cl19864 337191003965 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 337191003966 Phage-related minor tail protein [Function unknown]; Region: COG5280 337191003967 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 337191003968 Phage-related protein [Function unknown]; Region: COG5412 337191003969 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 337191003970 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 337191003971 TolA protein; Region: tolA_full; TIGR02794 337191003972 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 337191003973 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 337191003974 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 337191003975 active site 337191003976 Cutinase; Region: Cutinase; pfam01083 337191003977 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 337191003978 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 337191003979 active site 337191003980 oxyanion hole [active] 337191003981 catalytic triad [active] 337191003982 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 337191003983 Domain of unknown function (DUF4429); Region: DUF4429; pfam14472 337191003984 Bacterial PH domain; Region: bPH_3; pfam14470 337191003985 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 337191003986 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191003987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191003988 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 337191003989 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 337191003990 AzlC protein; Region: AzlC; pfam03591 337191003991 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191003992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191003993 non-specific DNA binding site [nucleotide binding]; other site 337191003994 salt bridge; other site 337191003995 sequence-specific DNA binding site [nucleotide binding]; other site 337191003996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 337191003997 DEAD-like helicases superfamily; Region: DEXDc; smart00487 337191003998 ATP binding site [chemical binding]; other site 337191003999 putative Mg++ binding site [ion binding]; other site 337191004000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191004001 nucleotide binding region [chemical binding]; other site 337191004002 ATP-binding site [chemical binding]; other site 337191004003 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 337191004004 DinB superfamily; Region: DinB_2; cl19195 337191004005 SCP-2 sterol transfer family; Region: SCP2; cl01225 337191004006 EamA-like transporter family; Region: EamA; pfam00892 337191004007 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 337191004008 EamA-like transporter family; Region: EamA; pfam00892 337191004009 Ferredoxin [Energy production and conversion]; Region: COG1146 337191004010 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 337191004011 4Fe-4S binding domain; Region: Fer4; pfam00037 337191004012 ferredoxin-NADP+ reductase; Region: PLN02852 337191004013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191004014 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 337191004015 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 337191004016 phosphopeptide binding site; other site 337191004017 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 337191004018 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 337191004019 Protein kinase domain; Region: Pkinase; pfam00069 337191004020 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191004021 active site 337191004022 ATP binding site [chemical binding]; other site 337191004023 substrate binding site [chemical binding]; other site 337191004024 activation loop (A-loop); other site 337191004025 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 337191004026 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 337191004027 active site 337191004028 ATP binding site [chemical binding]; other site 337191004029 substrate binding site [chemical binding]; other site 337191004030 activation loop (A-loop); other site 337191004031 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191004032 Ligand Binding Site [chemical binding]; other site 337191004033 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191004034 Ligand Binding Site [chemical binding]; other site 337191004035 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 337191004036 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 337191004037 DNA binding residues [nucleotide binding] 337191004038 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 337191004039 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 337191004040 active site 337191004041 nucleophile elbow; other site 337191004042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191004043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191004044 putative substrate translocation pore; other site 337191004045 arginine deiminase; Provisional; Region: PRK01388 337191004046 Predicted transcriptional regulators [Transcription]; Region: COG1725 337191004047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191004048 DNA-binding site [nucleotide binding]; DNA binding site 337191004049 BCCT family transporter; Region: BCCT; pfam02028 337191004050 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 337191004051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191004052 DNA-binding site [nucleotide binding]; DNA binding site 337191004053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191004054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191004055 homodimer interface [polypeptide binding]; other site 337191004056 catalytic residue [active] 337191004057 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 337191004058 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 337191004059 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 337191004060 putative homodimer interface [polypeptide binding]; other site 337191004061 putative SAM binding site [chemical binding]; other site 337191004062 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 337191004063 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 337191004064 chorismate binding enzyme; Region: Chorismate_bind; cl10555 337191004065 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 337191004066 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 337191004067 active site 337191004068 HIGH motif; other site 337191004069 KMSKS motif; other site 337191004070 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 337191004071 tRNA binding surface [nucleotide binding]; other site 337191004072 anticodon binding site; other site 337191004073 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191004074 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191004075 active site 337191004076 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191004077 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 337191004078 DNA binding residues [nucleotide binding] 337191004079 HEAT repeats; Region: HEAT_2; pfam13646 337191004080 HEAT repeats; Region: HEAT_2; pfam13646 337191004081 HEAT repeats; Region: HEAT_2; pfam13646 337191004082 HEAT repeats; Region: HEAT_2; pfam13646 337191004083 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 337191004084 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 337191004085 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 337191004086 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 337191004087 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 337191004088 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 337191004089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191004090 motif II; other site 337191004091 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 337191004092 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 337191004093 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 337191004094 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 337191004095 active site 337191004096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 337191004097 Domain of unknown function (DUF348); Region: DUF348; pfam03990 337191004098 Domain of unknown function (DUF348); Region: DUF348; pfam03990 337191004099 Domain of unknown function (DUF348); Region: DUF348; pfam03990 337191004100 G5 domain; Region: G5; pfam07501 337191004101 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 337191004102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191004103 S-adenosylmethionine binding site [chemical binding]; other site 337191004104 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191004105 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 337191004106 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 337191004107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191004108 motif II; other site 337191004109 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 337191004110 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 337191004111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191004112 Secretory lipase; Region: LIP; pfam03583 337191004113 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191004114 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 337191004115 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191004116 ABC transporter; Region: ABC_tran_2; pfam12848 337191004117 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191004118 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 337191004119 active site 337191004120 catalytic triad [active] 337191004121 oxyanion hole [active] 337191004122 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191004123 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191004124 active site 337191004125 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191004126 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191004127 active site 337191004128 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 337191004129 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191004130 dimer interface [polypeptide binding]; other site 337191004131 active site 337191004132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191004133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004134 NAD(P) binding site [chemical binding]; other site 337191004135 active site 337191004136 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191004137 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191004138 active site 337191004139 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191004140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004141 NAD(P) binding site [chemical binding]; other site 337191004142 active site 337191004143 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 337191004144 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191004145 dimer interface [polypeptide binding]; other site 337191004146 active site 337191004147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191004148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191004149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 337191004150 dimerization interface [polypeptide binding]; other site 337191004151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191004152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191004153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 337191004154 dimerization interface [polypeptide binding]; other site 337191004155 enoyl-CoA hydratase; Provisional; Region: PRK08252 337191004156 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191004157 substrate binding site [chemical binding]; other site 337191004158 oxyanion hole (OAH) forming residues; other site 337191004159 trimer interface [polypeptide binding]; other site 337191004160 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 337191004161 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 337191004162 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 337191004163 catalytic site [active] 337191004164 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 337191004165 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 337191004166 Walker A/P-loop; other site 337191004167 ATP binding site [chemical binding]; other site 337191004168 Q-loop/lid; other site 337191004169 ABC transporter signature motif; other site 337191004170 Walker B; other site 337191004171 D-loop; other site 337191004172 H-loop/switch region; other site 337191004173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191004174 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 337191004175 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191004176 substrate binding site [chemical binding]; other site 337191004177 oxyanion hole (OAH) forming residues; other site 337191004178 trimer interface [polypeptide binding]; other site 337191004179 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 337191004180 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 337191004181 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 337191004182 G1 box; other site 337191004183 putative GEF interaction site [polypeptide binding]; other site 337191004184 GTP/Mg2+ binding site [chemical binding]; other site 337191004185 Switch I region; other site 337191004186 G2 box; other site 337191004187 G3 box; other site 337191004188 Switch II region; other site 337191004189 G4 box; other site 337191004190 G5 box; other site 337191004191 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 337191004192 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191004193 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 337191004194 putative active site [active] 337191004195 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 337191004196 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 337191004197 dimer interface [polypeptide binding]; other site 337191004198 active site 337191004199 CoA binding pocket [chemical binding]; other site 337191004200 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 337191004201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191004202 Walker A/P-loop; other site 337191004203 ATP binding site [chemical binding]; other site 337191004204 Q-loop/lid; other site 337191004205 ABC transporter signature motif; other site 337191004206 Walker B; other site 337191004207 D-loop; other site 337191004208 H-loop/switch region; other site 337191004209 ABC-2 type transporter; Region: ABC2_membrane; cl17235 337191004210 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191004211 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 337191004212 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 337191004213 dimer interface [polypeptide binding]; other site 337191004214 active site 337191004215 CoA binding pocket [chemical binding]; other site 337191004216 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 337191004217 putative active site [active] 337191004218 catalytic residue [active] 337191004219 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 337191004220 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 337191004221 5S rRNA interface [nucleotide binding]; other site 337191004222 CTC domain interface [polypeptide binding]; other site 337191004223 L16 interface [polypeptide binding]; other site 337191004224 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 337191004225 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 337191004226 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 337191004227 catalytic residues [active] 337191004228 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 337191004229 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 337191004230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191004231 active site 337191004232 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 337191004233 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 337191004234 Substrate binding site; other site 337191004235 Mg++ binding site; other site 337191004236 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 337191004237 active site 337191004238 substrate binding site [chemical binding]; other site 337191004239 CoA binding site [chemical binding]; other site 337191004240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004241 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191004242 NAD(P) binding site [chemical binding]; other site 337191004243 active site 337191004244 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 337191004245 active site 337191004246 non-prolyl cis peptide bond; other site 337191004247 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191004248 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 337191004249 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 337191004250 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 337191004251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191004252 dimer interface [polypeptide binding]; other site 337191004253 conserved gate region; other site 337191004254 putative PBP binding loops; other site 337191004255 ABC-ATPase subunit interface; other site 337191004256 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 337191004257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191004258 Walker A/P-loop; other site 337191004259 ATP binding site [chemical binding]; other site 337191004260 Q-loop/lid; other site 337191004261 ABC transporter signature motif; other site 337191004262 Walker B; other site 337191004263 D-loop; other site 337191004264 H-loop/switch region; other site 337191004265 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 337191004266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191004267 dimer interface [polypeptide binding]; other site 337191004268 conserved gate region; other site 337191004269 putative PBP binding loops; other site 337191004270 ABC-ATPase subunit interface; other site 337191004271 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 337191004272 putative active site [active] 337191004273 redox center [active] 337191004274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191004275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191004276 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 337191004277 putative cation:proton antiport protein; Provisional; Region: PRK10669 337191004278 TrkA-N domain; Region: TrkA_N; pfam02254 337191004279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 337191004280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191004281 Coenzyme A binding pocket [chemical binding]; other site 337191004282 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 337191004283 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 337191004284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191004285 ATP binding site [chemical binding]; other site 337191004286 putative Mg++ binding site [ion binding]; other site 337191004287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191004288 nucleotide binding region [chemical binding]; other site 337191004289 ATP-binding site [chemical binding]; other site 337191004290 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 337191004291 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 337191004292 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 337191004293 homodimer interface [polypeptide binding]; other site 337191004294 metal binding site [ion binding]; metal-binding site 337191004295 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 337191004296 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191004297 active site 337191004298 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 337191004299 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 337191004300 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 337191004301 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 337191004302 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 337191004303 Walker A/P-loop; other site 337191004304 ATP binding site [chemical binding]; other site 337191004305 Q-loop/lid; other site 337191004306 ABC transporter signature motif; other site 337191004307 Walker B; other site 337191004308 D-loop; other site 337191004309 H-loop/switch region; other site 337191004310 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 337191004311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191004312 dimer interface [polypeptide binding]; other site 337191004313 conserved gate region; other site 337191004314 putative PBP binding loops; other site 337191004315 ABC-ATPase subunit interface; other site 337191004316 oxidase reductase; Provisional; Region: PTZ00273 337191004317 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 337191004318 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 337191004319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 337191004320 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191004321 DNA-binding site [nucleotide binding]; DNA binding site 337191004322 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 337191004323 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 337191004324 Sulfatase; Region: Sulfatase; pfam00884 337191004325 C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707 337191004326 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 337191004327 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 337191004328 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 337191004329 Active Sites [active] 337191004330 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 337191004331 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 337191004332 CysD dimerization site [polypeptide binding]; other site 337191004333 G1 box; other site 337191004334 putative GEF interaction site [polypeptide binding]; other site 337191004335 GTP/Mg2+ binding site [chemical binding]; other site 337191004336 Switch I region; other site 337191004337 G2 box; other site 337191004338 G3 box; other site 337191004339 Switch II region; other site 337191004340 G4 box; other site 337191004341 G5 box; other site 337191004342 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 337191004343 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 337191004344 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 337191004345 ligand-binding site [chemical binding]; other site 337191004346 Uncharacterized conserved protein [Function unknown]; Region: COG1262 337191004347 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 337191004348 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 337191004349 N-acetyl-D-glucosamine binding site [chemical binding]; other site 337191004350 enolase; Provisional; Region: eno; PRK00077 337191004351 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 337191004352 dimer interface [polypeptide binding]; other site 337191004353 metal binding site [ion binding]; metal-binding site 337191004354 substrate binding pocket [chemical binding]; other site 337191004355 Septum formation initiator; Region: DivIC; pfam04977 337191004356 Uncharacterized conserved protein [Function unknown]; Region: COG1507 337191004357 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 337191004358 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 337191004359 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 337191004360 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 337191004361 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 337191004362 putative di-iron ligands [ion binding]; other site 337191004363 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 337191004364 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191004365 FAD binding pocket [chemical binding]; other site 337191004366 FAD binding motif [chemical binding]; other site 337191004367 phosphate binding motif [ion binding]; other site 337191004368 beta-alpha-beta structure motif; other site 337191004369 NAD binding pocket [chemical binding]; other site 337191004370 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191004371 catalytic loop [active] 337191004372 iron binding site [ion binding]; other site 337191004373 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 337191004374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191004375 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 337191004376 active site 337191004377 dimer interface [polypeptide binding]; other site 337191004378 non-prolyl cis peptide bond; other site 337191004379 insertion regions; other site 337191004380 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 337191004381 active site 337191004382 dimer interface [polypeptide binding]; other site 337191004383 non-prolyl cis peptide bond; other site 337191004384 insertion regions; other site 337191004385 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 337191004386 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191004387 active site 337191004388 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 337191004389 putative metal binding site [ion binding]; other site 337191004390 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 337191004391 putative metal binding site [ion binding]; other site 337191004392 YibE/F-like protein; Region: YibE_F; pfam07907 337191004393 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 337191004394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191004395 dimer interface [polypeptide binding]; other site 337191004396 conserved gate region; other site 337191004397 putative PBP binding loops; other site 337191004398 ABC-ATPase subunit interface; other site 337191004399 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 337191004400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191004401 Walker A/P-loop; other site 337191004402 ATP binding site [chemical binding]; other site 337191004403 Q-loop/lid; other site 337191004404 ABC transporter signature motif; other site 337191004405 Walker B; other site 337191004406 D-loop; other site 337191004407 H-loop/switch region; other site 337191004408 NIL domain; Region: NIL; cl09633 337191004409 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 337191004410 DinB superfamily; Region: DinB_2; pfam12867 337191004411 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 337191004412 membrane glycoprotein; Provisional; Region: PHA03332 337191004413 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 337191004414 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 337191004415 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191004416 Putative esterase; Region: Esterase; pfam00756 337191004417 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191004418 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191004419 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 337191004420 Predicted esterase [General function prediction only]; Region: COG0627 337191004421 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191004422 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 337191004423 NAD binding site [chemical binding]; other site 337191004424 catalytic residues [active] 337191004425 Uncharacterized conserved protein [Function unknown]; Region: COG1359 337191004426 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 337191004427 MMPL family; Region: MMPL; cl14618 337191004428 MMPL family; Region: MMPL; cl14618 337191004429 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 337191004430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191004431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 337191004432 active site 337191004433 catalytic tetrad [active] 337191004434 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 337191004435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191004436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191004437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191004438 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 337191004439 Ferredoxin [Energy production and conversion]; Region: COG1146 337191004440 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 337191004441 4Fe-4S binding domain; Region: Fer4; pfam00037 337191004442 ferredoxin-NADP+ reductase; Region: PLN02852 337191004443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191004444 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191004445 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 337191004446 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191004447 acyl-activating enzyme (AAE) consensus motif; other site 337191004448 AMP binding site [chemical binding]; other site 337191004449 active site 337191004450 CoA binding site [chemical binding]; other site 337191004451 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 337191004452 NAD(P) binding site [chemical binding]; other site 337191004453 catalytic residues [active] 337191004454 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191004455 classical (c) SDRs; Region: SDR_c; cd05233 337191004456 NAD(P) binding site [chemical binding]; other site 337191004457 active site 337191004458 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 337191004459 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 337191004460 Permease; Region: Permease; pfam02405 337191004461 Permease; Region: Permease; pfam02405 337191004462 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191004463 mce related protein; Region: MCE; pfam02470 337191004464 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191004465 mce related protein; Region: MCE; pfam02470 337191004466 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191004467 mce related protein; Region: MCE; pfam02470 337191004468 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191004469 mce related protein; Region: MCE; pfam02470 337191004470 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191004471 mce related protein; Region: MCE; pfam02470 337191004472 mce related protein; Region: MCE; pfam02470 337191004473 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191004474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 337191004475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191004476 Reductase C-terminal; Region: Reductase_C; pfam14759 337191004477 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 337191004478 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191004479 dimer interface [polypeptide binding]; other site 337191004480 active site 337191004481 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 337191004482 putative active site [active] 337191004483 putative catalytic site [active] 337191004484 enoyl-CoA hydratase; Provisional; Region: PRK08252 337191004485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191004486 substrate binding site [chemical binding]; other site 337191004487 oxyanion hole (OAH) forming residues; other site 337191004488 trimer interface [polypeptide binding]; other site 337191004489 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191004490 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191004491 active site 337191004492 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191004493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004494 NAD(P) binding site [chemical binding]; other site 337191004495 active site 337191004496 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191004497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004498 NAD(P) binding site [chemical binding]; other site 337191004499 active site 337191004500 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191004501 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191004502 active site 337191004503 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 337191004504 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191004505 dimer interface [polypeptide binding]; other site 337191004506 active site 337191004507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004508 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 337191004509 NAD(P) binding site [chemical binding]; other site 337191004510 active site 337191004511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191004512 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 337191004513 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191004514 active site 337191004515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191004516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191004517 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 337191004518 enoyl-CoA hydratase; Provisional; Region: PRK06688 337191004519 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191004520 substrate binding site [chemical binding]; other site 337191004521 oxyanion hole (OAH) forming residues; other site 337191004522 trimer interface [polypeptide binding]; other site 337191004523 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191004524 CoenzymeA binding site [chemical binding]; other site 337191004525 subunit interaction site [polypeptide binding]; other site 337191004526 PHB binding site; other site 337191004527 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 337191004528 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 337191004529 Walker A/P-loop; other site 337191004530 ATP binding site [chemical binding]; other site 337191004531 Q-loop/lid; other site 337191004532 ABC transporter signature motif; other site 337191004533 Walker B; other site 337191004534 D-loop; other site 337191004535 H-loop/switch region; other site 337191004536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191004537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191004538 active site 337191004539 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 337191004540 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 337191004541 acyl-activating enzyme (AAE) consensus motif; other site 337191004542 putative AMP binding site [chemical binding]; other site 337191004543 putative active site [active] 337191004544 putative CoA binding site [chemical binding]; other site 337191004545 enoyl-CoA hydratase; Provisional; Region: PRK08260 337191004546 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191004547 substrate binding site [chemical binding]; other site 337191004548 oxyanion hole (OAH) forming residues; other site 337191004549 trimer interface [polypeptide binding]; other site 337191004550 phosphoenolpyruvate synthase; Validated; Region: PRK06241 337191004551 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 337191004552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004553 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 337191004554 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 337191004555 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 337191004556 Integrase core domain; Region: rve; pfam00665 337191004557 Integrase core domain; Region: rve_3; pfam13683 337191004558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 337191004559 Transposase, Mutator family; Region: Transposase_mut; cl19537 337191004560 Transposase, Mutator family; Region: Transposase_mut; cl19537 337191004561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 337191004562 UDP-glucoronosyl/UDP-glucosyl transferase family protein; Region: PLN02410 337191004563 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 337191004564 Homeodomain-like domain; Region: HTH_23; cl17451 337191004565 Winged helix-turn helix; Region: HTH_29; pfam13551 337191004566 Integrase core domain; Region: rve; pfam00665 337191004567 Integrase core domain; Region: rve_3; pfam13683 337191004568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191004569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191004570 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 337191004571 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191004572 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191004573 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191004574 Transcriptional regulators [Transcription]; Region: PurR; COG1609 337191004575 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 337191004576 DNA binding site [nucleotide binding] 337191004577 domain linker motif; other site 337191004578 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 337191004579 ligand binding site [chemical binding]; other site 337191004580 dimerization interface [polypeptide binding]; other site 337191004581 putative transporter; Provisional; Region: PRK10504 337191004582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191004583 putative substrate translocation pore; other site 337191004584 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 337191004585 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 337191004586 active site 337191004587 substrate binding site [chemical binding]; other site 337191004588 FMN binding site [chemical binding]; other site 337191004589 putative catalytic residues [active] 337191004590 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 337191004591 N- and C-terminal domain interface [polypeptide binding]; other site 337191004592 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 337191004593 active site 337191004594 putative catalytic site [active] 337191004595 metal binding site [ion binding]; metal-binding site 337191004596 ATP binding site [chemical binding]; other site 337191004597 carbohydrate binding site [chemical binding]; other site 337191004598 short chain dehydrogenase; Validated; Region: PRK08324 337191004599 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 337191004600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004601 NAD(P) binding site [chemical binding]; other site 337191004602 active site 337191004603 L-rhamnose isomerase (RhaA); Region: RhaA; cl19165 337191004604 benzoate transport; Region: 2A0115; TIGR00895 337191004605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191004606 putative substrate translocation pore; other site 337191004607 Domain of unknown function (DUF718); Region: DUF718; pfam05336 337191004608 short chain dehydrogenase; Provisional; Region: PRK06181 337191004609 classical (c) SDRs; Region: SDR_c; cd05233 337191004610 NAD(P) binding site [chemical binding]; other site 337191004611 active site 337191004612 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 337191004613 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 337191004614 MMPL family; Region: MMPL; cl14618 337191004615 MMPL family; Region: MMPL; cl14618 337191004616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191004617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191004618 WHG domain; Region: WHG; pfam13305 337191004619 Bax inhibitor 1 like; Region: BaxI_1; cl17691 337191004620 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 337191004621 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191004622 dimer interface [polypeptide binding]; other site 337191004623 active site 337191004624 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 337191004625 active site 337191004626 catalytic triad [active] 337191004627 oxyanion hole [active] 337191004628 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 337191004629 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 337191004630 dimer interface [polypeptide binding]; other site 337191004631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191004632 catalytic residue [active] 337191004633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 337191004634 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 337191004635 homodimer interface [polypeptide binding]; other site 337191004636 substrate-cofactor binding pocket; other site 337191004637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191004638 catalytic residue [active] 337191004639 Methyltransferase domain; Region: Methyltransf_31; pfam13847 337191004640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191004641 S-adenosylmethionine binding site [chemical binding]; other site 337191004642 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 337191004643 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 337191004644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 337191004645 threonine dehydratase; Provisional; Region: PRK08198 337191004646 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 337191004647 tetramer interface [polypeptide binding]; other site 337191004648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191004649 catalytic residue [active] 337191004650 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 337191004651 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 337191004652 DNA binding site [nucleotide binding] 337191004653 Bacterial transcriptional activator domain; Region: BTAD; smart01043 337191004654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191004655 Walker A motif; other site 337191004656 ATP binding site [chemical binding]; other site 337191004657 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191004658 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 337191004659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191004660 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 337191004661 Walker A/P-loop; other site 337191004662 ATP binding site [chemical binding]; other site 337191004663 Q-loop/lid; other site 337191004664 ABC transporter signature motif; other site 337191004665 Walker B; other site 337191004666 D-loop; other site 337191004667 H-loop/switch region; other site 337191004668 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191004669 hydrophobic ligand binding site; other site 337191004670 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 337191004671 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191004672 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 337191004673 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 337191004674 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 337191004675 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 337191004676 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 337191004677 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 337191004678 TspO/MBR family; Region: TspO_MBR; pfam03073 337191004679 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 337191004680 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 337191004681 inhibitor-cofactor binding pocket; inhibition site 337191004682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191004683 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191004684 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 337191004685 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 337191004686 PhoD-like phosphatase; Region: PhoD; pfam09423 337191004687 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 337191004688 putative active site [active] 337191004689 putative metal binding site [ion binding]; other site 337191004690 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 337191004691 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 337191004692 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 337191004693 Haemolysin-III related; Region: HlyIII; cl03831 337191004694 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 337191004695 active site 337191004696 dimer interface [polypeptide binding]; other site 337191004697 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 337191004698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191004699 DNA-binding site [nucleotide binding]; DNA binding site 337191004700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191004701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191004702 homodimer interface [polypeptide binding]; other site 337191004703 catalytic residue [active] 337191004704 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 337191004705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191004706 NAD(P) binding site [chemical binding]; other site 337191004707 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 337191004708 Uncharacterized conserved protein [Function unknown]; Region: COG2128 337191004709 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 337191004710 ATP-binding site [chemical binding]; other site 337191004711 CoA-binding site [chemical binding]; other site 337191004712 Mg2+-binding site [ion binding]; other site 337191004713 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 337191004714 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 337191004715 dimer interface [polypeptide binding]; other site 337191004716 active site 337191004717 glycine-pyridoxal phosphate binding site [chemical binding]; other site 337191004718 folate binding site [chemical binding]; other site 337191004719 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 337191004720 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 337191004721 dinuclear metal binding motif [ion binding]; other site 337191004722 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 337191004723 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 337191004724 putative active site [active] 337191004725 PhoH-like protein; Region: PhoH; pfam02562 337191004726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 337191004727 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191004728 Ligand Binding Site [chemical binding]; other site 337191004729 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191004730 Ligand Binding Site [chemical binding]; other site 337191004731 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191004732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191004733 active site 337191004734 phosphorylation site [posttranslational modification] 337191004735 intermolecular recognition site; other site 337191004736 dimerization interface [polypeptide binding]; other site 337191004737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191004738 DNA binding residues [nucleotide binding] 337191004739 dimerization interface [polypeptide binding]; other site 337191004740 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 337191004741 GAF domain; Region: GAF; pfam01590 337191004742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 337191004743 Histidine kinase; Region: HisKA_3; pfam07730 337191004744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191004745 ATP binding site [chemical binding]; other site 337191004746 Mg2+ binding site [ion binding]; other site 337191004747 G-X-G motif; other site 337191004748 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 337191004749 fumarate hydratase; Reviewed; Region: fumC; PRK00485 337191004750 Class II fumarases; Region: Fumarase_classII; cd01362 337191004751 active site 337191004752 tetramer interface [polypeptide binding]; other site 337191004753 fumarate hydratase; Provisional; Region: PRK15389 337191004754 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 337191004755 Fumarase C-terminus; Region: Fumerase_C; pfam05683 337191004756 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 337191004757 putative active site [active] 337191004758 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 337191004759 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 337191004760 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 337191004761 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 337191004762 generic binding surface II; other site 337191004763 generic binding surface I; other site 337191004764 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 337191004765 Fe-S cluster binding site [ion binding]; other site 337191004766 substrate binding site [chemical binding]; other site 337191004767 catalytic site [active] 337191004768 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 337191004769 Subtilase family; Region: Peptidase_S8; pfam00082 337191004770 active site 337191004771 catalytic residues [active] 337191004772 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 337191004773 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 337191004774 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 337191004775 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 337191004776 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 337191004777 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 337191004778 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 337191004779 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 337191004780 23S rRNA interface [nucleotide binding]; other site 337191004781 L3 interface [polypeptide binding]; other site 337191004782 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 337191004783 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 337191004784 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 337191004785 active site 337191004786 substrate binding site [chemical binding]; other site 337191004787 metal binding site [ion binding]; metal-binding site 337191004788 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 337191004789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191004790 motif II; other site 337191004791 Sporozoite P67 surface antigen; Region: Sporozoite_P67; pfam05642 337191004792 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191004793 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191004794 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 337191004795 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 337191004796 glutaminase active site [active] 337191004797 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 337191004798 dimer interface [polypeptide binding]; other site 337191004799 active site 337191004800 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 337191004801 dimer interface [polypeptide binding]; other site 337191004802 active site 337191004803 Uncharacterized conserved protein [Function unknown]; Region: COG0062 337191004804 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 337191004805 putative substrate binding site [chemical binding]; other site 337191004806 putative ATP binding site [chemical binding]; other site 337191004807 alanine racemase; Reviewed; Region: alr; PRK00053 337191004808 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 337191004809 active site 337191004810 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 337191004811 dimer interface [polypeptide binding]; other site 337191004812 substrate binding site [chemical binding]; other site 337191004813 catalytic residues [active] 337191004814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191004815 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191004816 TAP-like protein; Region: Abhydrolase_4; pfam08386 337191004817 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 337191004818 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 337191004819 Glycoprotease family; Region: Peptidase_M22; pfam00814 337191004820 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 337191004821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191004822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191004823 Coenzyme A binding pocket [chemical binding]; other site 337191004824 UGMP family protein; Validated; Region: PRK09604 337191004825 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 337191004826 oligomerisation interface [polypeptide binding]; other site 337191004827 mobile loop; other site 337191004828 roof hairpin; other site 337191004829 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 337191004830 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 337191004831 ring oligomerisation interface [polypeptide binding]; other site 337191004832 ATP/Mg binding site [chemical binding]; other site 337191004833 stacking interactions; other site 337191004834 hinge regions; other site 337191004835 Transcription factor WhiB; Region: Whib; pfam02467 337191004836 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 337191004837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191004838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191004839 DNA binding residues [nucleotide binding] 337191004840 Vta1 like; Region: DUF605; pfam04652 337191004841 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 337191004842 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 337191004843 active site 337191004844 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 337191004845 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 337191004846 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 337191004847 phosphate binding site [ion binding]; other site 337191004848 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 337191004849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191004850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191004851 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 337191004852 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 337191004853 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 337191004854 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 337191004855 Walker A/P-loop; other site 337191004856 ATP binding site [chemical binding]; other site 337191004857 Q-loop/lid; other site 337191004858 ABC transporter signature motif; other site 337191004859 Walker B; other site 337191004860 D-loop; other site 337191004861 H-loop/switch region; other site 337191004862 BioY family; Region: BioY; pfam02632 337191004863 GMP synthase; Reviewed; Region: guaA; PRK00074 337191004864 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 337191004865 AMP/PPi binding site [chemical binding]; other site 337191004866 candidate oxyanion hole; other site 337191004867 catalytic triad [active] 337191004868 potential glutamine specificity residues [chemical binding]; other site 337191004869 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 337191004870 ATP Binding subdomain [chemical binding]; other site 337191004871 Ligand Binding sites [chemical binding]; other site 337191004872 Dimerization subdomain; other site 337191004873 PspC domain; Region: PspC; pfam04024 337191004874 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 337191004875 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 337191004876 PspC domain; Region: PspC; pfam04024 337191004877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 337191004878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191004879 ATP binding site [chemical binding]; other site 337191004880 Mg2+ binding site [ion binding]; other site 337191004881 G-X-G motif; other site 337191004882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191004883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191004884 active site 337191004885 phosphorylation site [posttranslational modification] 337191004886 intermolecular recognition site; other site 337191004887 dimerization interface [polypeptide binding]; other site 337191004888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191004889 DNA binding residues [nucleotide binding] 337191004890 dimerization interface [polypeptide binding]; other site 337191004891 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191004892 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191004893 active site 337191004894 ATP binding site [chemical binding]; other site 337191004895 substrate binding site [chemical binding]; other site 337191004896 activation loop (A-loop); other site 337191004897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191004898 Radical SAM superfamily; Region: Radical_SAM; pfam04055 337191004899 FeS/SAM binding site; other site 337191004900 DNA Polymerase Y-family; Region: PolY_like; cd03468 337191004901 active site 337191004902 DNA binding site [nucleotide binding] 337191004903 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 337191004904 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 337191004905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 337191004906 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 337191004907 catalytic residue [active] 337191004908 short chain dehydrogenase; Provisional; Region: PRK07201 337191004909 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 337191004910 putative NAD(P) binding site [chemical binding]; other site 337191004911 active site 337191004912 putative substrate binding site [chemical binding]; other site 337191004913 classical (c) SDRs; Region: SDR_c; cd05233 337191004914 NAD(P) binding site [chemical binding]; other site 337191004915 active site 337191004916 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 337191004917 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 337191004918 Soluble P-type ATPase [General function prediction only]; Region: COG4087 337191004919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191004920 dimerization interface [polypeptide binding]; other site 337191004921 putative DNA binding site [nucleotide binding]; other site 337191004922 putative Zn2+ binding site [ion binding]; other site 337191004923 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 337191004924 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 337191004925 active site 337191004926 PHP Thumb interface [polypeptide binding]; other site 337191004927 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 337191004928 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 337191004929 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 337191004930 generic binding surface II; other site 337191004931 generic binding surface I; other site 337191004932 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 337191004933 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 337191004934 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 337191004935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191004936 catalytic residue [active] 337191004937 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 337191004938 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 337191004939 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 337191004940 homodimer interface [polypeptide binding]; other site 337191004941 NADP binding site [chemical binding]; other site 337191004942 substrate binding site [chemical binding]; other site 337191004943 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 337191004944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 337191004945 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 337191004946 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 337191004947 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 337191004948 homodimer interface [polypeptide binding]; other site 337191004949 substrate-cofactor binding pocket; other site 337191004950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191004951 catalytic residue [active] 337191004952 PE-PPE domain; Region: PE-PPE; pfam08237 337191004953 Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208 337191004954 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 337191004955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191004956 putative substrate translocation pore; other site 337191004957 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 337191004958 Ferritin-like domain; Region: Ferritin; pfam00210 337191004959 heme binding site [chemical binding]; other site 337191004960 ferroxidase pore; other site 337191004961 ferroxidase diiron center [ion binding]; other site 337191004962 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 337191004963 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 337191004964 putative catalytic site [active] 337191004965 putative metal binding site [ion binding]; other site 337191004966 putative phosphate binding site [ion binding]; other site 337191004967 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 337191004968 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 337191004969 active site 337191004970 HIGH motif; other site 337191004971 dimer interface [polypeptide binding]; other site 337191004972 KMSKS motif; other site 337191004973 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 337191004974 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 337191004975 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 337191004976 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 337191004977 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 337191004978 catalytic triad [active] 337191004979 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191004980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191004981 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 337191004982 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 337191004983 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 337191004984 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 337191004985 L-aspartate oxidase; Provisional; Region: PRK06175 337191004986 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 337191004987 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 337191004988 putative Iron-sulfur protein interface [polypeptide binding]; other site 337191004989 putative proximal heme binding site [chemical binding]; other site 337191004990 putative SdhC-like subunit interface [polypeptide binding]; other site 337191004991 putative distal heme binding site [chemical binding]; other site 337191004992 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 337191004993 putative Iron-sulfur protein interface [polypeptide binding]; other site 337191004994 putative proximal heme binding site [chemical binding]; other site 337191004995 putative SdhD-like interface [polypeptide binding]; other site 337191004996 putative distal heme binding site [chemical binding]; other site 337191004997 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 337191004998 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 337191004999 active site 337191005000 catalytic motif [active] 337191005001 Zn binding site [ion binding]; other site 337191005002 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 337191005003 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 337191005004 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 337191005005 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 337191005006 adenosine deaminase; Provisional; Region: PRK09358 337191005007 active site 337191005008 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 337191005009 NlpC/P60 family; Region: NLPC_P60; pfam00877 337191005010 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191005011 active site 337191005012 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191005013 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191005014 active site 337191005015 purine nucleoside phosphorylase; Provisional; Region: PRK08202 337191005016 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 337191005017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191005018 substrate binding site [chemical binding]; other site 337191005019 oxyanion hole (OAH) forming residues; other site 337191005020 trimer interface [polypeptide binding]; other site 337191005021 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 337191005022 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 337191005023 metal binding site [ion binding]; metal-binding site 337191005024 putative dimer interface [polypeptide binding]; other site 337191005025 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 337191005026 putative active site pocket [active] 337191005027 dimerization interface [polypeptide binding]; other site 337191005028 putative catalytic residue [active] 337191005029 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 337191005030 hypothetical protein; Provisional; Region: PRK07236 337191005031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191005032 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 337191005033 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 337191005034 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 337191005035 glycerol kinase; Provisional; Region: glpK; PRK00047 337191005036 N- and C-terminal domain interface [polypeptide binding]; other site 337191005037 active site 337191005038 MgATP binding site [chemical binding]; other site 337191005039 catalytic site [active] 337191005040 metal binding site [ion binding]; metal-binding site 337191005041 putative homotetramer interface [polypeptide binding]; other site 337191005042 glycerol binding site [chemical binding]; other site 337191005043 homodimer interface [polypeptide binding]; other site 337191005044 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 337191005045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191005046 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 337191005047 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 337191005048 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 337191005049 putative DNA binding site [nucleotide binding]; other site 337191005050 catalytic residue [active] 337191005051 putative H2TH interface [polypeptide binding]; other site 337191005052 putative catalytic residues [active] 337191005053 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 337191005054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191005055 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 337191005056 ATP binding site [chemical binding]; other site 337191005057 putative Mg++ binding site [ion binding]; other site 337191005058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191005059 nucleotide binding region [chemical binding]; other site 337191005060 ATP-binding site [chemical binding]; other site 337191005061 DEAD/H associated; Region: DEAD_assoc; pfam08494 337191005062 Winged helix DNA-binding domain; Region: HTH_42; cl19833 337191005063 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 337191005064 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 337191005065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191005066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191005067 active site 337191005068 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 337191005069 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 337191005070 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 337191005071 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 337191005072 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 337191005073 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 337191005074 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 337191005075 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 337191005076 FAD binding domain; Region: FAD_binding_4; cl19922 337191005077 4-hydroxybenzoyl-CoA reductase, beta subunit; Region: 4hydrxCoA_B; TIGR03195 337191005078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191005079 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191005080 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 337191005081 active site 337191005082 catalytic triad [active] 337191005083 oxyanion hole [active] 337191005084 pyruvate carboxylase; Reviewed; Region: PRK12999 337191005085 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 337191005086 ATP-grasp domain; Region: ATP-grasp_4; cl17255 337191005087 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 337191005088 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 337191005089 active site 337191005090 catalytic residues [active] 337191005091 metal binding site [ion binding]; metal-binding site 337191005092 homodimer binding site [polypeptide binding]; other site 337191005093 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 337191005094 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 337191005095 carboxyltransferase (CT) interaction site; other site 337191005096 biotinylation site [posttranslational modification]; other site 337191005097 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 337191005098 active site 337191005099 homotetramer interface [polypeptide binding]; other site 337191005100 putative OHCU decarboxylase; Provisional; Region: PRK13798 337191005101 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191005102 active site 337191005103 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 337191005104 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 337191005105 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 337191005106 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 337191005107 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 337191005108 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 337191005109 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 337191005110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191005111 catalytic loop [active] 337191005112 iron binding site [ion binding]; other site 337191005113 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 337191005114 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 337191005115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191005116 Nitronate monooxygenase; Region: NMO; pfam03060 337191005117 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 337191005118 FMN binding site [chemical binding]; other site 337191005119 putative catalytic residue [active] 337191005120 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 337191005121 active site residue [active] 337191005122 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191005123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191005124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 337191005125 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 337191005126 putative active site [active] 337191005127 heme pocket [chemical binding]; other site 337191005128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 337191005129 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 337191005130 putative active site [active] 337191005131 heme pocket [chemical binding]; other site 337191005132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191005133 dimer interface [polypeptide binding]; other site 337191005134 phosphorylation site [posttranslational modification] 337191005135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191005136 ATP binding site [chemical binding]; other site 337191005137 Mg2+ binding site [ion binding]; other site 337191005138 G-X-G motif; other site 337191005139 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191005140 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191005141 active site 337191005142 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 337191005143 [2Fe-2S] cluster binding site [ion binding]; other site 337191005144 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 337191005145 putative alpha subunit interface [polypeptide binding]; other site 337191005146 putative active site [active] 337191005147 putative substrate binding site [chemical binding]; other site 337191005148 Fe binding site [ion binding]; other site 337191005149 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 337191005150 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 337191005151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191005152 NAD(P) binding site [chemical binding]; other site 337191005153 active site 337191005154 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191005155 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 337191005156 FMN-binding pocket [chemical binding]; other site 337191005157 flavin binding motif; other site 337191005158 phosphate binding motif [ion binding]; other site 337191005159 beta-alpha-beta structure motif; other site 337191005160 NAD binding pocket [chemical binding]; other site 337191005161 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191005162 catalytic loop [active] 337191005163 iron binding site [ion binding]; other site 337191005164 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 337191005165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191005166 active site 337191005167 phosphorylation site [posttranslational modification] 337191005168 intermolecular recognition site; other site 337191005169 dimerization interface [polypeptide binding]; other site 337191005170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191005171 DNA binding residues [nucleotide binding] 337191005172 dimerization interface [polypeptide binding]; other site 337191005173 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 337191005174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191005175 D-galactonate transporter; Region: 2A0114; TIGR00893 337191005176 putative substrate translocation pore; other site 337191005177 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 337191005178 SnoaL-like domain; Region: SnoaL_4; pfam13577 337191005179 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191005180 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191005181 active site 337191005182 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 337191005183 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 337191005184 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 337191005185 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 337191005186 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 337191005187 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 337191005188 carboxyltransferase (CT) interaction site; other site 337191005189 biotinylation site [posttranslational modification]; other site 337191005190 Condensation domain; Region: Condensation; cl19241 337191005191 Fe-S metabolizm associated domain; Region: SufE; cl00951 337191005192 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 337191005193 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 337191005194 active site residue [active] 337191005195 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 337191005196 active site residue [active] 337191005197 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 337191005198 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 337191005199 active site 337191005200 dimer interface [polypeptide binding]; other site 337191005201 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 337191005202 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 337191005203 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 337191005204 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 337191005205 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 337191005206 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 337191005207 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 337191005208 Rhomboid family; Region: Rhomboid; cl11446 337191005209 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 337191005210 Bacterial PH domain; Region: bPH_2; pfam03703 337191005211 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 337191005212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191005213 active site 337191005214 phosphorylation site [posttranslational modification] 337191005215 intermolecular recognition site; other site 337191005216 dimerization interface [polypeptide binding]; other site 337191005217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191005218 DNA binding site [nucleotide binding] 337191005219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 337191005220 HAMP domain; Region: HAMP; pfam00672 337191005221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191005222 dimer interface [polypeptide binding]; other site 337191005223 phosphorylation site [posttranslational modification] 337191005224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191005225 ATP binding site [chemical binding]; other site 337191005226 Mg2+ binding site [ion binding]; other site 337191005227 G-X-G motif; other site 337191005228 Predicted membrane protein [Function unknown]; Region: COG2246 337191005229 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 337191005230 ATP-grasp domain; Region: ATP-grasp_4; cl17255 337191005231 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 337191005232 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 337191005233 Domain of unknown function (DUF385); Region: DUF385; cl04387 337191005234 TIGR03089 family protein; Region: TIGR03089 337191005235 Transcriptional regulator [Transcription]; Region: LytR; COG1316 337191005236 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 337191005237 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 337191005238 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 337191005239 NADP binding site [chemical binding]; other site 337191005240 active site 337191005241 putative substrate binding site [chemical binding]; other site 337191005242 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 337191005243 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 337191005244 Probable Catalytic site; other site 337191005245 metal-binding site 337191005246 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 337191005247 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 337191005248 active site 337191005249 Substrate binding site; other site 337191005250 Mg++ binding site; other site 337191005251 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 337191005252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191005253 S-adenosylmethionine binding site [chemical binding]; other site 337191005254 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 337191005255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191005256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191005257 DNA binding residues [nucleotide binding] 337191005258 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 337191005259 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 337191005260 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 337191005261 protein binding site [polypeptide binding]; other site 337191005262 sec-independent translocase; Provisional; Region: PRK03100 337191005263 sec-independent translocase; Provisional; Region: tatB; PRK00404 337191005264 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 337191005265 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 337191005266 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 337191005267 Walker A motif; other site 337191005268 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 337191005269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 337191005270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 337191005271 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 337191005272 PRC-barrel domain; Region: PRC; pfam05239 337191005273 MgtE intracellular N domain; Region: MgtE_N; smart00924 337191005274 FOG: CBS domain [General function prediction only]; Region: COG0517 337191005275 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 337191005276 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 337191005277 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 337191005278 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 337191005279 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 337191005280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191005281 dimer interface [polypeptide binding]; other site 337191005282 conserved gate region; other site 337191005283 putative PBP binding loops; other site 337191005284 ABC-ATPase subunit interface; other site 337191005285 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 337191005286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191005287 dimer interface [polypeptide binding]; other site 337191005288 conserved gate region; other site 337191005289 ABC-ATPase subunit interface; other site 337191005290 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 337191005291 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 337191005292 Walker A/P-loop; other site 337191005293 ATP binding site [chemical binding]; other site 337191005294 Q-loop/lid; other site 337191005295 ABC transporter signature motif; other site 337191005296 Walker B; other site 337191005297 D-loop; other site 337191005298 H-loop/switch region; other site 337191005299 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 337191005300 active site 337191005301 metal binding site [ion binding]; metal-binding site 337191005302 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 337191005303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191005304 S-adenosylmethionine binding site [chemical binding]; other site 337191005305 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 337191005306 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 337191005307 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 337191005308 minor groove reading motif; other site 337191005309 helix-hairpin-helix signature motif; other site 337191005310 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 337191005311 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 337191005312 oligomer interface [polypeptide binding]; other site 337191005313 metal binding site [ion binding]; metal-binding site 337191005314 metal binding site [ion binding]; metal-binding site 337191005315 putative Cl binding site [ion binding]; other site 337191005316 basic sphincter; other site 337191005317 hydrophobic gate; other site 337191005318 periplasmic entrance; other site 337191005319 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 337191005320 hypothetical protein; Provisional; Region: PRK06194 337191005321 classical (c) SDRs; Region: SDR_c; cd05233 337191005322 NAD(P) binding site [chemical binding]; other site 337191005323 active site 337191005324 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191005325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191005326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191005327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191005328 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 337191005329 Condensation domain; Region: Condensation; cl19241 337191005330 Condensation domain; Region: Condensation; cl19241 337191005331 Condensation domain; Region: Condensation; cl19241 337191005332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191005333 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 337191005334 Walker A/P-loop; other site 337191005335 ATP binding site [chemical binding]; other site 337191005336 Q-loop/lid; other site 337191005337 ABC transporter signature motif; other site 337191005338 Walker B; other site 337191005339 D-loop; other site 337191005340 H-loop/switch region; other site 337191005341 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 337191005342 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 337191005343 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191005344 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 337191005345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 337191005346 active site 337191005347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191005348 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 337191005349 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 337191005350 homodimer interface [polypeptide binding]; other site 337191005351 active site 337191005352 TDP-binding site; other site 337191005353 acceptor substrate-binding pocket; other site 337191005354 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 337191005355 homodimer interface [polypeptide binding]; other site 337191005356 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 337191005357 active site 337191005358 TDP-binding site; other site 337191005359 acceptor substrate-binding pocket; other site 337191005360 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191005361 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191005362 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 337191005363 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 337191005364 active site 337191005365 TDP-binding site; other site 337191005366 acceptor substrate-binding pocket; other site 337191005367 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 337191005368 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 337191005369 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 337191005370 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 337191005371 TPP-binding site [chemical binding]; other site 337191005372 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 337191005373 dimer interface [polypeptide binding]; other site 337191005374 PYR/PP interface [polypeptide binding]; other site 337191005375 TPP binding site [chemical binding]; other site 337191005376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191005377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191005378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191005379 Walker A/P-loop; other site 337191005380 ATP binding site [chemical binding]; other site 337191005381 Q-loop/lid; other site 337191005382 ABC transporter signature motif; other site 337191005383 Walker B; other site 337191005384 D-loop; other site 337191005385 H-loop/switch region; other site 337191005386 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191005387 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191005388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191005389 Walker A/P-loop; other site 337191005390 ATP binding site [chemical binding]; other site 337191005391 Q-loop/lid; other site 337191005392 ABC transporter signature motif; other site 337191005393 Walker B; other site 337191005394 D-loop; other site 337191005395 H-loop/switch region; other site 337191005396 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 337191005397 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 337191005398 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 337191005399 putative dimer interface [polypeptide binding]; other site 337191005400 N-terminal domain interface [polypeptide binding]; other site 337191005401 putative substrate binding pocket (H-site) [chemical binding]; other site 337191005402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191005403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191005404 putative substrate translocation pore; other site 337191005405 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 337191005406 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 337191005407 active site 337191005408 metal binding site [ion binding]; metal-binding site 337191005409 DNA binding site [nucleotide binding] 337191005410 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 337191005411 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 337191005412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191005413 Walker A/P-loop; other site 337191005414 ATP binding site [chemical binding]; other site 337191005415 Q-loop/lid; other site 337191005416 Walker B; other site 337191005417 D-loop; other site 337191005418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191005419 ABC transporter signature motif; other site 337191005420 Walker B; other site 337191005421 D-loop; other site 337191005422 H-loop/switch region; other site 337191005423 MspA; Region: MspA; pfam09203 337191005424 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 337191005425 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 337191005426 PA/protease or protease-like domain interface [polypeptide binding]; other site 337191005427 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191005428 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191005429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191005430 Domain of unknown function (DUF305); Region: DUF305; pfam03713 337191005431 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 337191005432 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 337191005433 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 337191005434 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 337191005435 active site 337191005436 HIGH motif; other site 337191005437 KMSK motif region; other site 337191005438 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 337191005439 tRNA binding surface [nucleotide binding]; other site 337191005440 anticodon binding site; other site 337191005441 diaminopimelate decarboxylase; Region: lysA; TIGR01048 337191005442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 337191005443 active site 337191005444 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 337191005445 substrate binding site [chemical binding]; other site 337191005446 catalytic residues [active] 337191005447 dimer interface [polypeptide binding]; other site 337191005448 homoserine dehydrogenase; Provisional; Region: PRK06349 337191005449 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 337191005450 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 337191005451 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 337191005452 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 337191005453 homodimer interface [polypeptide binding]; other site 337191005454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191005455 catalytic residue [active] 337191005456 homoserine kinase; Provisional; Region: PRK01212 337191005457 transcription termination factor Rho; Provisional; Region: PRK12678 337191005458 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 337191005459 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 337191005460 RNA binding site [nucleotide binding]; other site 337191005461 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 337191005462 multimer interface [polypeptide binding]; other site 337191005463 Walker A motif; other site 337191005464 ATP binding site [chemical binding]; other site 337191005465 Walker B motif; other site 337191005466 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 337191005467 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 337191005468 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 337191005469 FAD binding pocket [chemical binding]; other site 337191005470 FAD binding motif [chemical binding]; other site 337191005471 catalytic residues [active] 337191005472 NAD binding pocket [chemical binding]; other site 337191005473 phosphate binding motif [ion binding]; other site 337191005474 beta-alpha-beta structure motif; other site 337191005475 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 337191005476 peptide chain release factor 1; Validated; Region: prfA; PRK00591 337191005477 PCRF domain; Region: PCRF; pfam03462 337191005478 RF-1 domain; Region: RF-1; pfam00472 337191005479 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 337191005480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191005481 S-adenosylmethionine binding site [chemical binding]; other site 337191005482 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 337191005483 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 337191005484 dimer interface [polypeptide binding]; other site 337191005485 active site 337191005486 glycine-pyridoxal phosphate binding site [chemical binding]; other site 337191005487 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 337191005488 folate binding site [chemical binding]; other site 337191005489 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 337191005490 Mg++ binding site [ion binding]; other site 337191005491 putative catalytic motif [active] 337191005492 substrate binding site [chemical binding]; other site 337191005493 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 337191005494 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 337191005495 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 337191005496 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 337191005497 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 337191005498 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 337191005499 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 337191005500 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 337191005501 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 337191005502 beta subunit interaction interface [polypeptide binding]; other site 337191005503 Walker A motif; other site 337191005504 ATP binding site [chemical binding]; other site 337191005505 Walker B motif; other site 337191005506 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 337191005507 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 337191005508 core domain interface [polypeptide binding]; other site 337191005509 delta subunit interface [polypeptide binding]; other site 337191005510 epsilon subunit interface [polypeptide binding]; other site 337191005511 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 337191005512 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 337191005513 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 337191005514 alpha subunit interaction interface [polypeptide binding]; other site 337191005515 Walker A motif; other site 337191005516 ATP binding site [chemical binding]; other site 337191005517 Walker B motif; other site 337191005518 inhibitor binding site; inhibition site 337191005519 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 337191005520 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 337191005521 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 337191005522 gamma subunit interface [polypeptide binding]; other site 337191005523 epsilon subunit interface [polypeptide binding]; other site 337191005524 LBP interface [polypeptide binding]; other site 337191005525 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 337191005526 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 337191005527 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 337191005528 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 337191005529 hinge; other site 337191005530 active site 337191005531 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 337191005532 dimer interface [polypeptide binding]; other site 337191005533 active site 337191005534 metal binding site [ion binding]; metal-binding site 337191005535 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 337191005536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191005537 Walker A motif; other site 337191005538 ATP binding site [chemical binding]; other site 337191005539 Walker B motif; other site 337191005540 arginine finger; other site 337191005541 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 337191005542 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 337191005543 active site 337191005544 NAD binding site [chemical binding]; other site 337191005545 metal binding site [ion binding]; metal-binding site 337191005546 GAF domain; Region: GAF_3; pfam13492 337191005547 Histidine kinase; Region: HisKA_3; pfam07730 337191005548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191005549 ATP binding site [chemical binding]; other site 337191005550 Mg2+ binding site [ion binding]; other site 337191005551 G-X-G motif; other site 337191005552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191005553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191005554 active site 337191005555 phosphorylation site [posttranslational modification] 337191005556 intermolecular recognition site; other site 337191005557 dimerization interface [polypeptide binding]; other site 337191005558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191005559 DNA binding residues [nucleotide binding] 337191005560 dimerization interface [polypeptide binding]; other site 337191005561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191005562 S-adenosylmethionine binding site [chemical binding]; other site 337191005563 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191005564 Ligand Binding Site [chemical binding]; other site 337191005565 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191005566 Ligand Binding Site [chemical binding]; other site 337191005567 glutaminase; Provisional; Region: PRK00971 337191005568 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 337191005569 hypothetical protein; Provisional; Region: PRK03298 337191005570 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 337191005571 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 337191005572 dimer interface [polypeptide binding]; other site 337191005573 substrate binding site [chemical binding]; other site 337191005574 metal binding site [ion binding]; metal-binding site 337191005575 putative acyltransferase; Provisional; Region: PRK05790 337191005576 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191005577 dimer interface [polypeptide binding]; other site 337191005578 active site 337191005579 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 337191005580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191005581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191005582 putative substrate translocation pore; other site 337191005583 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 337191005584 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 337191005585 Tetratricopeptide repeat; Region: TPR_20; pfam14561 337191005586 glycogen branching enzyme; Provisional; Region: PRK05402 337191005587 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 337191005588 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 337191005589 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 337191005590 active site 337191005591 catalytic site [active] 337191005592 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 337191005593 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 337191005594 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 337191005595 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 337191005596 active site 337191005597 catalytic site [active] 337191005598 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 337191005599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 337191005600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191005601 putative Mg++ binding site [ion binding]; other site 337191005602 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 337191005603 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 337191005604 catalytic triad [active] 337191005605 conserved cis-peptide bond; other site 337191005606 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 337191005607 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 337191005608 active site 337191005609 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 337191005610 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 337191005611 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 337191005612 putative active site pocket [active] 337191005613 cleavage site 337191005614 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 337191005615 MPN+ (JAMM) motif; other site 337191005616 Zinc-binding site [ion binding]; other site 337191005617 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 337191005618 MoaE interaction surface [polypeptide binding]; other site 337191005619 MoeB interaction surface [polypeptide binding]; other site 337191005620 thiocarboxylated glycine; other site 337191005621 cysteine synthase; Region: PLN02565 337191005622 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 337191005623 dimer interface [polypeptide binding]; other site 337191005624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191005625 catalytic residue [active] 337191005626 Rhomboid family; Region: Rhomboid; pfam01694 337191005627 glutamate racemase; Provisional; Region: PRK00865 337191005628 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 337191005629 ribonuclease PH; Reviewed; Region: rph; PRK00173 337191005630 Ribonuclease PH; Region: RNase_PH_bact; cd11362 337191005631 hexamer interface [polypeptide binding]; other site 337191005632 active site 337191005633 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 337191005634 active site 337191005635 dimerization interface [polypeptide binding]; other site 337191005636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191005637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191005638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191005639 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 337191005640 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 337191005641 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191005642 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 337191005643 Glucitol operon activator protein (GutM); Region: GutM; cl01890 337191005644 PQQ-like domain; Region: PQQ_2; pfam13360 337191005645 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 337191005646 active site 337191005647 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 337191005648 Lsr2; Region: Lsr2; pfam11774 337191005649 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 337191005650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191005651 S-adenosylmethionine binding site [chemical binding]; other site 337191005652 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191005653 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191005654 catalytic residue [active] 337191005655 OpgC protein; Region: OpgC_C; cl17858 337191005656 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 337191005657 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 337191005658 acyl-activating enzyme (AAE) consensus motif; other site 337191005659 putative AMP binding site [chemical binding]; other site 337191005660 putative active site [active] 337191005661 putative CoA binding site [chemical binding]; other site 337191005662 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 337191005663 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 337191005664 ATP binding site [chemical binding]; other site 337191005665 Mg++ binding site [ion binding]; other site 337191005666 motif III; other site 337191005667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191005668 nucleotide binding region [chemical binding]; other site 337191005669 ATP-binding site [chemical binding]; other site 337191005670 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 337191005671 putative RNA binding site [nucleotide binding]; other site 337191005672 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 337191005673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 337191005674 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 337191005675 AAA domain; Region: AAA_12; pfam13087 337191005676 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 337191005677 putative active site [active] 337191005678 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 337191005679 NAD+ binding site [chemical binding]; other site 337191005680 substrate binding site [chemical binding]; other site 337191005681 Zn binding site [ion binding]; other site 337191005682 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 337191005683 nucleotide binding site/active site [active] 337191005684 HIT family signature motif; other site 337191005685 catalytic residue [active] 337191005686 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 337191005687 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 337191005688 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 337191005689 phosphate binding site [ion binding]; other site 337191005690 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 337191005691 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191005692 active site 2 [active] 337191005693 active site 1 [active] 337191005694 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 337191005695 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 337191005696 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 337191005697 putative NAD(P) binding site [chemical binding]; other site 337191005698 active site 337191005699 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 337191005700 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 337191005701 active site 337191005702 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 337191005703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191005704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191005705 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 337191005706 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 337191005707 catalytic triad [active] 337191005708 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 337191005709 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 337191005710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 337191005711 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 337191005712 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 337191005713 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 337191005714 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 337191005715 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 337191005716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191005717 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 337191005718 DNA binding residues [nucleotide binding] 337191005719 YCII-related domain; Region: YCII; cl00999 337191005720 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 337191005721 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 337191005722 catalytic site [active] 337191005723 putative active site [active] 337191005724 putative substrate binding site [chemical binding]; other site 337191005725 dimer interface [polypeptide binding]; other site 337191005726 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 337191005727 Domain of unknown function DUF87; Region: DUF87; cl19135 337191005728 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 337191005729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191005730 NAD(P) binding site [chemical binding]; other site 337191005731 active site 337191005732 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 337191005733 active site 337191005734 FMN binding site [chemical binding]; other site 337191005735 2,4-decadienoyl-CoA binding site; other site 337191005736 catalytic residue [active] 337191005737 4Fe-4S cluster binding site [ion binding]; other site 337191005738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 337191005739 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191005740 Predicted transcriptional regulators [Transcription]; Region: COG1695 337191005741 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 337191005742 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 337191005743 Sulfate transporter family; Region: Sulfate_transp; cl19250 337191005744 Copper resistance protein D; Region: CopD; cl00563 337191005745 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 337191005746 chorismate mutase; Provisional; Region: PRK09269 337191005747 Chorismate mutase type II; Region: CM_2; cl00693 337191005748 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 337191005749 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 337191005750 dimer interface [polypeptide binding]; other site 337191005751 ssDNA binding site [nucleotide binding]; other site 337191005752 tetramer (dimer of dimers) interface [polypeptide binding]; other site 337191005753 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 337191005754 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 337191005755 anti sigma factor interaction site; other site 337191005756 regulatory phosphorylation site [posttranslational modification]; other site 337191005757 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 337191005758 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 337191005759 DXD motif; other site 337191005760 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 337191005761 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 337191005762 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 337191005763 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 337191005764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191005765 ABC transporter; Region: ABC_tran; pfam00005 337191005766 Walker A/P-loop; other site 337191005767 ATP binding site [chemical binding]; other site 337191005768 Q-loop/lid; other site 337191005769 ABC transporter signature motif; other site 337191005770 ABC transporter; Region: ABC_tran_2; pfam12848 337191005771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191005772 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 337191005773 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 337191005774 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 337191005775 active site 337191005776 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 337191005777 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 337191005778 active site 337191005779 catalytic site [active] 337191005780 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 337191005781 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 337191005782 apolar tunnel; other site 337191005783 heme binding site [chemical binding]; other site 337191005784 dimerization interface [polypeptide binding]; other site 337191005785 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191005786 active site 337191005787 Repair protein; Region: Repair_PSII; cl01535 337191005788 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 337191005789 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 337191005790 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 337191005791 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 337191005792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191005793 ATP binding site [chemical binding]; other site 337191005794 Mg2+ binding site [ion binding]; other site 337191005795 G-X-G motif; other site 337191005796 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 337191005797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191005798 active site 337191005799 phosphorylation site [posttranslational modification] 337191005800 intermolecular recognition site; other site 337191005801 dimerization interface [polypeptide binding]; other site 337191005802 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 337191005803 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 337191005804 Zn binding site [ion binding]; other site 337191005805 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 337191005806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191005807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191005808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191005809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191005810 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 337191005811 catalytic residues [active] 337191005812 Peptidase family M48; Region: Peptidase_M48; cl12018 337191005813 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 337191005814 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 337191005815 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 337191005816 putative DNA binding site [nucleotide binding]; other site 337191005817 catalytic residue [active] 337191005818 putative H2TH interface [polypeptide binding]; other site 337191005819 putative catalytic residues [active] 337191005820 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 337191005821 PE-PPE domain; Region: PE-PPE; pfam08237 337191005822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 337191005823 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 337191005824 trigger factor; Provisional; Region: tig; PRK01490 337191005825 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 337191005826 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 337191005827 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 337191005828 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 337191005829 oligomer interface [polypeptide binding]; other site 337191005830 active site residues [active] 337191005831 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 337191005832 oligomer interface [polypeptide binding]; other site 337191005833 active site residues [active] 337191005834 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 337191005835 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 337191005836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191005837 Walker A motif; other site 337191005838 ATP binding site [chemical binding]; other site 337191005839 Walker B motif; other site 337191005840 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 337191005841 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 337191005842 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 337191005843 putative molybdopterin cofactor binding site [chemical binding]; other site 337191005844 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 337191005845 putative molybdopterin cofactor binding site; other site 337191005846 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 337191005847 GTP binding site; other site 337191005848 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 337191005849 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 337191005850 active site 337191005851 HIGH motif; other site 337191005852 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 337191005853 KMSKS motif; other site 337191005854 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 337191005855 tRNA binding surface [nucleotide binding]; other site 337191005856 anticodon binding site; other site 337191005857 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 337191005858 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 337191005859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 337191005860 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 337191005861 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 337191005862 Nucleoside diphosphate kinase; Region: NDK; pfam00334 337191005863 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 337191005864 active site 337191005865 multimer interface [polypeptide binding]; other site 337191005866 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 337191005867 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 337191005868 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 337191005869 homodimer interface [polypeptide binding]; other site 337191005870 oligonucleotide binding site [chemical binding]; other site 337191005871 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 337191005872 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 337191005873 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 337191005874 GTPase CgtA; Reviewed; Region: obgE; PRK12296 337191005875 GTP1/OBG; Region: GTP1_OBG; pfam01018 337191005876 Obg GTPase; Region: Obg; cd01898 337191005877 G1 box; other site 337191005878 GTP/Mg2+ binding site [chemical binding]; other site 337191005879 Switch I region; other site 337191005880 G2 box; other site 337191005881 G3 box; other site 337191005882 Switch II region; other site 337191005883 G4 box; other site 337191005884 G5 box; other site 337191005885 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 337191005886 gamma-glutamyl kinase; Provisional; Region: PRK05429 337191005887 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 337191005888 nucleotide binding site [chemical binding]; other site 337191005889 homotetrameric interface [polypeptide binding]; other site 337191005890 putative phosphate binding site [ion binding]; other site 337191005891 putative allosteric binding site; other site 337191005892 PUA domain; Region: PUA; pfam01472 337191005893 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 337191005894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191005895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191005896 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191005897 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 337191005898 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 337191005899 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 337191005900 inhibitor-cofactor binding pocket; inhibition site 337191005901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191005902 catalytic residue [active] 337191005903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 337191005904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191005905 Coenzyme A binding pocket [chemical binding]; other site 337191005906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191005907 S-adenosylmethionine binding site [chemical binding]; other site 337191005908 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 337191005909 active site 337191005910 (T/H)XGH motif; other site 337191005911 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 337191005912 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 337191005913 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 337191005914 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 337191005915 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 337191005916 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 337191005917 dimerization interface [polypeptide binding]; other site 337191005918 active site 337191005919 metal binding site [ion binding]; metal-binding site 337191005920 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 337191005921 dsRNA binding site [nucleotide binding]; other site 337191005922 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 337191005923 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 337191005924 DNA binding site [nucleotide binding] 337191005925 catalytic residue [active] 337191005926 H2TH interface [polypeptide binding]; other site 337191005927 putative catalytic residues [active] 337191005928 turnover-facilitating residue; other site 337191005929 intercalation triad [nucleotide binding]; other site 337191005930 8OG recognition residue [nucleotide binding]; other site 337191005931 putative reading head residues; other site 337191005932 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 337191005933 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 337191005934 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 337191005935 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 337191005936 active site 337191005937 AAA domain; Region: AAA_23; pfam13476 337191005938 AAA domain; Region: AAA_21; pfam13304 337191005939 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 337191005940 Acylphosphatase; Region: Acylphosphatase; cl00551 337191005941 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 337191005942 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 337191005943 Walker A/P-loop; other site 337191005944 ATP binding site [chemical binding]; other site 337191005945 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 337191005946 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 337191005947 ABC transporter signature motif; other site 337191005948 Walker B; other site 337191005949 D-loop; other site 337191005950 H-loop/switch region; other site 337191005951 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 337191005952 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 337191005953 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 337191005954 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 337191005955 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 337191005956 PII uridylyl-transferase; Provisional; Region: PRK03381 337191005957 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 337191005958 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 337191005959 HD domain; Region: HD; pfam01966 337191005960 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 337191005961 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 337191005962 signal recognition particle protein; Provisional; Region: PRK10867 337191005963 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 337191005964 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 337191005965 P loop; other site 337191005966 GTP binding site [chemical binding]; other site 337191005967 Signal peptide binding domain; Region: SRP_SPB; pfam02978 337191005968 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191005969 Amidohydrolase; Region: Amidohydro_4; pfam13147 337191005970 active site 337191005971 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 337191005972 ribosomal protein S16; Region: S16; TIGR00002 337191005973 hypothetical protein; Provisional; Region: PRK02821 337191005974 G-X-X-G motif; other site 337191005975 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 337191005976 RimM N-terminal domain; Region: RimM; pfam01782 337191005977 PRC-barrel domain; Region: PRC; pfam05239 337191005978 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 337191005979 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 337191005980 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 337191005981 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 337191005982 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 337191005983 Catalytic site [active] 337191005984 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 337191005985 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 337191005986 RNA/DNA hybrid binding site [nucleotide binding]; other site 337191005987 active site 337191005988 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 337191005989 hypothetical protein; Reviewed; Region: PRK12497 337191005990 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 337191005991 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 337191005992 putative FMN binding site [chemical binding]; other site 337191005993 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 337191005994 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 337191005995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191005996 Walker A motif; other site 337191005997 ATP binding site [chemical binding]; other site 337191005998 Walker B motif; other site 337191005999 arginine finger; other site 337191006000 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 337191006001 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 337191006002 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 337191006003 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 337191006004 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 337191006005 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 337191006006 FAD binding pocket [chemical binding]; other site 337191006007 FAD binding motif [chemical binding]; other site 337191006008 phosphate binding motif [ion binding]; other site 337191006009 NAD binding pocket [chemical binding]; other site 337191006010 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 337191006011 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 337191006012 active site 337191006013 DNA binding site [nucleotide binding] 337191006014 Int/Topo IB signature motif; other site 337191006015 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 337191006016 Peptidase family M23; Region: Peptidase_M23; pfam01551 337191006017 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 337191006018 rRNA interaction site [nucleotide binding]; other site 337191006019 S8 interaction site; other site 337191006020 putative laminin-1 binding site; other site 337191006021 elongation factor Ts; Provisional; Region: tsf; PRK09377 337191006022 UBA/TS-N domain; Region: UBA; pfam00627 337191006023 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191006024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191006025 putative substrate translocation pore; other site 337191006026 Condensation domain; Region: Condensation; cl19241 337191006027 Predicted esterase [General function prediction only]; Region: COG0627 337191006028 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191006029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 337191006030 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 337191006031 putative nucleotide binding site [chemical binding]; other site 337191006032 uridine monophosphate binding site [chemical binding]; other site 337191006033 homohexameric interface [polypeptide binding]; other site 337191006034 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 337191006035 hinge region; other site 337191006036 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 337191006037 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 337191006038 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 337191006039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191006040 FeS/SAM binding site; other site 337191006041 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 337191006042 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 337191006043 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 337191006044 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 337191006045 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 337191006046 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 337191006047 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 337191006048 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 337191006049 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 337191006050 putative substrate binding region [chemical binding]; other site 337191006051 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 337191006052 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 337191006053 Predicted acetyltransferase [General function prediction only]; Region: COG3393 337191006054 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 337191006055 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 337191006056 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 337191006057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 337191006058 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 337191006059 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 337191006060 Walker A/P-loop; other site 337191006061 ATP binding site [chemical binding]; other site 337191006062 Q-loop/lid; other site 337191006063 ABC transporter signature motif; other site 337191006064 Walker B; other site 337191006065 D-loop; other site 337191006066 H-loop/switch region; other site 337191006067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 337191006068 ABC-ATPase subunit interface; other site 337191006069 dimer interface [polypeptide binding]; other site 337191006070 putative PBP binding regions; other site 337191006071 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 337191006072 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 337191006073 intersubunit interface [polypeptide binding]; other site 337191006074 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 337191006075 active site 337191006076 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191006077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191006078 active site 337191006079 ATP binding site [chemical binding]; other site 337191006080 substrate binding site [chemical binding]; other site 337191006081 activation loop (A-loop); other site 337191006082 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191006083 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191006084 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191006085 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191006086 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 337191006087 cobyric acid synthase; Provisional; Region: PRK00784 337191006088 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191006089 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 337191006090 catalytic triad [active] 337191006091 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191006092 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191006093 mycothione reductase; Reviewed; Region: PRK07846 337191006094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191006095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191006096 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 337191006097 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 337191006098 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191006099 malate:quinone oxidoreductase; Validated; Region: PRK05257 337191006100 Predicted dehydrogenase [General function prediction only]; Region: COG0579 337191006101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191006102 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 337191006103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191006104 Walker A motif; other site 337191006105 ATP binding site [chemical binding]; other site 337191006106 Walker B motif; other site 337191006107 arginine finger; other site 337191006108 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 337191006109 metal ion-dependent adhesion site (MIDAS); other site 337191006110 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 337191006111 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 337191006112 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 337191006113 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191006114 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 337191006115 catalytic triad [active] 337191006116 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 337191006117 Histidine kinase; Region: HisKA_3; pfam07730 337191006118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191006119 ATP binding site [chemical binding]; other site 337191006120 Mg2+ binding site [ion binding]; other site 337191006121 G-X-G motif; other site 337191006122 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191006123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191006124 active site 337191006125 phosphorylation site [posttranslational modification] 337191006126 intermolecular recognition site; other site 337191006127 dimerization interface [polypeptide binding]; other site 337191006128 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191006129 DNA binding residues [nucleotide binding] 337191006130 dimerization interface [polypeptide binding]; other site 337191006131 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 337191006132 homodimer interface [polypeptide binding]; other site 337191006133 putative substrate binding pocket [chemical binding]; other site 337191006134 diiron center [ion binding]; other site 337191006135 siroheme synthase; Provisional; Region: cysG; PRK10637 337191006136 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 337191006137 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 337191006138 active site 337191006139 SAM binding site [chemical binding]; other site 337191006140 homodimer interface [polypeptide binding]; other site 337191006141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191006142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191006143 putative substrate translocation pore; other site 337191006144 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 337191006145 hypothetical protein; Validated; Region: PRK02101 337191006146 prolyl-tRNA synthetase; Provisional; Region: PRK09194 337191006147 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 337191006148 dimer interface [polypeptide binding]; other site 337191006149 motif 1; other site 337191006150 active site 337191006151 motif 2; other site 337191006152 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 337191006153 putative deacylase active site [active] 337191006154 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 337191006155 anticodon binding site; other site 337191006156 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 337191006157 dinuclear metal binding motif [ion binding]; other site 337191006158 Sm and related proteins; Region: Sm_like; cl00259 337191006159 heptamer interface [polypeptide binding]; other site 337191006160 Sm1 motif; other site 337191006161 hexamer interface [polypeptide binding]; other site 337191006162 RNA binding site [nucleotide binding]; other site 337191006163 Sm2 motif; other site 337191006164 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 337191006165 NusA N-terminal domain; Region: NusA_N; pfam08529 337191006166 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 337191006167 RNA binding site [nucleotide binding]; other site 337191006168 homodimer interface [polypeptide binding]; other site 337191006169 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 337191006170 G-X-X-G motif; other site 337191006171 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 337191006172 G-X-X-G motif; other site 337191006173 Protein of unknown function (DUF448); Region: DUF448; pfam04296 337191006174 putative RNA binding cleft [nucleotide binding]; other site 337191006175 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 337191006176 translation initiation factor IF-2; Validated; Region: infB; PRK05306 337191006177 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 337191006178 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 337191006179 G1 box; other site 337191006180 putative GEF interaction site [polypeptide binding]; other site 337191006181 GTP/Mg2+ binding site [chemical binding]; other site 337191006182 Switch I region; other site 337191006183 G2 box; other site 337191006184 G3 box; other site 337191006185 Switch II region; other site 337191006186 G4 box; other site 337191006187 G5 box; other site 337191006188 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 337191006189 Translation-initiation factor 2; Region: IF-2; pfam11987 337191006190 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 337191006191 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 337191006192 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 337191006193 DHH family; Region: DHH; pfam01368 337191006194 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 337191006195 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 337191006196 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 337191006197 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 337191006198 active site 337191006199 metal binding site [ion binding]; metal-binding site 337191006200 Replication protein C N-terminal domain; Region: RP-C; pfam03428 337191006201 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 337191006202 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 337191006203 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 337191006204 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 337191006205 RNA binding site [nucleotide binding]; other site 337191006206 active site 337191006207 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 337191006208 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 337191006209 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 337191006210 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 337191006211 FeoA domain; Region: FeoA; pfam04023 337191006212 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 337191006213 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 337191006214 active site 337191006215 Riboflavin kinase; Region: Flavokinase; smart00904 337191006216 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 337191006217 16S/18S rRNA binding site [nucleotide binding]; other site 337191006218 S13e-L30e interaction site [polypeptide binding]; other site 337191006219 25S rRNA binding site [nucleotide binding]; other site 337191006220 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 337191006221 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 337191006222 oligomer interface [polypeptide binding]; other site 337191006223 RNA binding site [nucleotide binding]; other site 337191006224 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 337191006225 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 337191006226 RNase E interface [polypeptide binding]; other site 337191006227 trimer interface [polypeptide binding]; other site 337191006228 active site 337191006229 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 337191006230 putative nucleic acid binding region [nucleotide binding]; other site 337191006231 G-X-X-G motif; other site 337191006232 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 337191006233 RNA binding site [nucleotide binding]; other site 337191006234 domain interface; other site 337191006235 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 337191006236 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 337191006237 metal binding triad; other site 337191006238 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 337191006239 NRDE protein; Region: NRDE; cl01315 337191006240 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 337191006241 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 337191006242 hexamer interface [polypeptide binding]; other site 337191006243 ligand binding site [chemical binding]; other site 337191006244 putative active site [active] 337191006245 NAD(P) binding site [chemical binding]; other site 337191006246 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191006247 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191006248 putative DNA binding site [nucleotide binding]; other site 337191006249 putative Zn2+ binding site [ion binding]; other site 337191006250 AsnC family; Region: AsnC_trans_reg; pfam01037 337191006251 dihydrodipicolinate reductase; Provisional; Region: PRK00048 337191006252 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 337191006253 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 337191006254 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 337191006255 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191006256 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191006257 active site 337191006258 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191006259 active site 337191006260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191006261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191006262 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 337191006263 dimerization interface [polypeptide binding]; other site 337191006264 active site 337191006265 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 337191006266 folate binding site [chemical binding]; other site 337191006267 NADP+ binding site [chemical binding]; other site 337191006268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 337191006269 Eukaryotic phosphomannomutase; Region: PMM; cl17107 337191006270 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 337191006271 PhoD-like phosphatase; Region: PhoD; pfam09423 337191006272 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 337191006273 putative active site [active] 337191006274 putative metal binding site [ion binding]; other site 337191006275 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 337191006276 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 337191006277 dimer interface [polypeptide binding]; other site 337191006278 active site 337191006279 catalytic residue [active] 337191006280 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 337191006281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191006282 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 337191006283 DinB superfamily; Region: DinB_2; cl19195 337191006284 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 337191006285 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 337191006286 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 337191006287 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 337191006288 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 337191006289 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 337191006290 YCII-related domain; Region: YCII; cl00999 337191006291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191006292 Coenzyme A binding pocket [chemical binding]; other site 337191006293 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 337191006294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191006295 non-specific DNA binding site [nucleotide binding]; other site 337191006296 salt bridge; other site 337191006297 sequence-specific DNA binding site [nucleotide binding]; other site 337191006298 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 337191006299 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 337191006300 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191006301 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 337191006302 recombinase A; Provisional; Region: recA; PRK09354 337191006303 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 337191006304 hexamer interface [polypeptide binding]; other site 337191006305 Walker A motif; other site 337191006306 ATP binding site [chemical binding]; other site 337191006307 Walker B motif; other site 337191006308 recombination regulator RecX; Reviewed; Region: recX; PRK00117 337191006309 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 337191006310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191006311 dimer interface [polypeptide binding]; other site 337191006312 conserved gate region; other site 337191006313 putative PBP binding loops; other site 337191006314 ABC-ATPase subunit interface; other site 337191006315 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 337191006316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191006317 dimer interface [polypeptide binding]; other site 337191006318 conserved gate region; other site 337191006319 putative PBP binding loops; other site 337191006320 ABC-ATPase subunit interface; other site 337191006321 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 337191006322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 337191006323 substrate binding pocket [chemical binding]; other site 337191006324 membrane-bound complex binding site; other site 337191006325 hinge residues; other site 337191006326 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 337191006327 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 337191006328 Walker A/P-loop; other site 337191006329 ATP binding site [chemical binding]; other site 337191006330 Q-loop/lid; other site 337191006331 ABC transporter signature motif; other site 337191006332 Walker B; other site 337191006333 D-loop; other site 337191006334 H-loop/switch region; other site 337191006335 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 337191006336 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 337191006337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191006338 FeS/SAM binding site; other site 337191006339 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 337191006340 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 337191006341 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 337191006342 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 337191006343 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 337191006344 active site 337191006345 metal binding site [ion binding]; metal-binding site 337191006346 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 337191006347 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 337191006348 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 337191006349 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 337191006350 GTPases [General function prediction only]; Region: HflX; COG2262 337191006351 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 337191006352 HflX GTPase family; Region: HflX; cd01878 337191006353 G1 box; other site 337191006354 GTP/Mg2+ binding site [chemical binding]; other site 337191006355 Switch I region; other site 337191006356 G2 box; other site 337191006357 G3 box; other site 337191006358 Switch II region; other site 337191006359 G4 box; other site 337191006360 G5 box; other site 337191006361 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 337191006362 dimerization domain swap beta strand [polypeptide binding]; other site 337191006363 regulatory protein interface [polypeptide binding]; other site 337191006364 active site 337191006365 regulatory phosphorylation site [posttranslational modification]; other site 337191006366 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 337191006367 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 337191006368 active site 337191006369 phosphorylation site [posttranslational modification] 337191006370 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 337191006371 active site 337191006372 P-loop; other site 337191006373 phosphorylation site [posttranslational modification] 337191006374 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 337191006375 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 337191006376 putative substrate binding site [chemical binding]; other site 337191006377 putative ATP binding site [chemical binding]; other site 337191006378 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 337191006379 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 337191006380 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 337191006381 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 337191006382 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 337191006383 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 337191006384 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 337191006385 LexA repressor; Validated; Region: PRK00215 337191006386 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 337191006387 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 337191006388 Catalytic site [active] 337191006389 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 337191006390 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 337191006391 C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit; Region: Zn-ribbon; cl02609 337191006392 Zn binding site [ion binding]; other site 337191006393 ATP cone domain; Region: ATP-cone; pfam03477 337191006394 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 337191006395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191006396 ATP binding site [chemical binding]; other site 337191006397 putative Mg++ binding site [ion binding]; other site 337191006398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191006399 nucleotide binding region [chemical binding]; other site 337191006400 ATP-binding site [chemical binding]; other site 337191006401 Helicase associated domain (HA2); Region: HA2; pfam04408 337191006402 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 337191006403 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 337191006404 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 337191006405 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 337191006406 inhibitor-cofactor binding pocket; inhibition site 337191006407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191006408 catalytic residue [active] 337191006409 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 337191006410 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 337191006411 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 337191006412 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 337191006413 dimer interface [polypeptide binding]; other site 337191006414 decamer (pentamer of dimers) interface [polypeptide binding]; other site 337191006415 catalytic triad [active] 337191006416 peroxidatic and resolving cysteines [active] 337191006417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191006418 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 337191006419 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 337191006420 dimerization interface [polypeptide binding]; other site 337191006421 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191006422 ATP binding site [chemical binding]; other site 337191006423 putative Mg++ binding site [ion binding]; other site 337191006424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191006425 nucleotide binding region [chemical binding]; other site 337191006426 ATP-binding site [chemical binding]; other site 337191006427 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 337191006428 PAC2 family; Region: PAC2; pfam09754 337191006429 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 337191006430 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 337191006431 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 337191006432 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 337191006433 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 337191006434 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 337191006435 active site 337191006436 Zn binding site [ion binding]; other site 337191006437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 337191006438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191006439 Coenzyme A binding pocket [chemical binding]; other site 337191006440 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 337191006441 CoA binding domain; Region: CoA_binding_2; pfam13380 337191006442 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 337191006443 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 337191006444 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 337191006445 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 337191006446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191006447 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 337191006448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191006449 DNA binding residues [nucleotide binding] 337191006450 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 337191006451 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 337191006452 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 337191006453 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 337191006454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191006455 ATP binding site [chemical binding]; other site 337191006456 putative Mg++ binding site [ion binding]; other site 337191006457 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 337191006458 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 337191006459 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 337191006460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191006461 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 337191006462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191006463 DNA binding residues [nucleotide binding] 337191006464 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 337191006465 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 337191006466 nucleotide binding site [chemical binding]; other site 337191006467 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 337191006468 active site 337191006469 dimerization interface [polypeptide binding]; other site 337191006470 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 337191006471 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 337191006472 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 337191006473 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 337191006474 trimer interface [polypeptide binding]; other site 337191006475 active site 337191006476 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 337191006477 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191006478 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 337191006479 ssDNA binding site; other site 337191006480 generic binding surface II; other site 337191006481 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 337191006482 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 337191006483 TrkA-N domain; Region: TrkA_N; pfam02254 337191006484 TrkA-C domain; Region: TrkA_C; pfam02080 337191006485 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 337191006486 TrkA-N domain; Region: TrkA_N; pfam02254 337191006487 TrkA-C domain; Region: TrkA_C; pfam02080 337191006488 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 337191006489 TRAM domain; Region: TRAM; pfam01938 337191006490 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 337191006491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 337191006492 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 337191006493 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 337191006494 TPP-binding site; other site 337191006495 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 337191006496 PYR/PP interface [polypeptide binding]; other site 337191006497 dimer interface [polypeptide binding]; other site 337191006498 TPP binding site [chemical binding]; other site 337191006499 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 337191006500 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 337191006501 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 337191006502 hydrophobic ligand binding site; other site 337191006503 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 337191006504 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 337191006505 catalytic site [active] 337191006506 putative active site [active] 337191006507 putative substrate binding site [chemical binding]; other site 337191006508 HRDC domain; Region: HRDC; cl02578 337191006509 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 337191006510 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 337191006511 substrate binding site [chemical binding]; other site 337191006512 active site 337191006513 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 337191006514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191006515 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 337191006516 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 337191006517 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 337191006518 TAP-like protein; Region: Abhydrolase_4; pfam08386 337191006519 hypothetical protein; Provisional; Region: PRK14059 337191006520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 337191006521 Walker A motif; other site 337191006522 ATP binding site [chemical binding]; other site 337191006523 Walker B motif; other site 337191006524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191006525 Walker A motif; other site 337191006526 ATP binding site [chemical binding]; other site 337191006527 Walker B motif; other site 337191006528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191006529 Coenzyme A binding pocket [chemical binding]; other site 337191006530 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 337191006531 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 337191006532 active site residue [active] 337191006533 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 337191006534 active site residue [active] 337191006535 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191006536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191006537 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 337191006538 FMN binding site [chemical binding]; other site 337191006539 dimer interface [polypeptide binding]; other site 337191006540 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 337191006541 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191006542 acyl-activating enzyme (AAE) consensus motif; other site 337191006543 AMP binding site [chemical binding]; other site 337191006544 active site 337191006545 CoA binding site [chemical binding]; other site 337191006546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191006547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191006548 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191006549 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 337191006550 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 337191006551 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 337191006552 active site 337191006553 Int/Topo IB signature motif; other site 337191006554 DNA binding site [nucleotide binding] 337191006555 Phage capsid family; Region: Phage_capsid; pfam05065 337191006556 large tegument protein UL36; Provisional; Region: PHA03247 337191006557 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 337191006558 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 337191006559 synthetase active site [active] 337191006560 NTP binding site [chemical binding]; other site 337191006561 metal binding site [ion binding]; metal-binding site 337191006562 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 337191006563 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 337191006564 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 337191006565 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 337191006566 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 337191006567 active site 337191006568 dimer interface [polypeptide binding]; other site 337191006569 motif 1; other site 337191006570 motif 2; other site 337191006571 motif 3; other site 337191006572 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 337191006573 anticodon binding site; other site 337191006574 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 337191006575 nucleotide binding site/active site [active] 337191006576 HIT family signature motif; other site 337191006577 catalytic residue [active] 337191006578 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 337191006579 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 337191006580 putative acyl-acceptor binding pocket; other site 337191006581 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191006582 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 337191006583 LemA family; Region: LemA; cl00742 337191006584 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 337191006585 active site 337191006586 multimer interface [polypeptide binding]; other site 337191006587 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 337191006588 active site 337191006589 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 337191006590 active site 337191006591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 337191006592 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191006593 DNA binding residues [nucleotide binding] 337191006594 dimerization interface [polypeptide binding]; other site 337191006595 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 337191006596 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 337191006597 active site 337191006598 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 337191006599 catalytic triad [active] 337191006600 dimer interface [polypeptide binding]; other site 337191006601 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 337191006602 predicted active site [active] 337191006603 catalytic triad [active] 337191006604 hypothetical protein; Validated; Region: PRK00110 337191006605 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 337191006606 active site 337191006607 putative DNA-binding cleft [nucleotide binding]; other site 337191006608 dimer interface [polypeptide binding]; other site 337191006609 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 337191006610 RuvA N terminal domain; Region: RuvA_N; pfam01330 337191006611 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 337191006612 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 337191006613 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 337191006614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191006615 Walker A motif; other site 337191006616 ATP binding site [chemical binding]; other site 337191006617 Walker B motif; other site 337191006618 arginine finger; other site 337191006619 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 337191006620 Preprotein translocase subunit; Region: YajC; pfam02699 337191006621 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 337191006622 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 337191006623 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 337191006624 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 337191006625 Protein export membrane protein; Region: SecD_SecF; pfam02355 337191006626 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191006627 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 337191006628 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191006629 active site 337191006630 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 337191006631 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 337191006632 Zn2+ binding site [ion binding]; other site 337191006633 Mg2+ binding site [ion binding]; other site 337191006634 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 337191006635 synthetase active site [active] 337191006636 NTP binding site [chemical binding]; other site 337191006637 metal binding site [ion binding]; metal-binding site 337191006638 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 337191006639 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 337191006640 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 337191006641 active site 337191006642 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 337191006643 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 337191006644 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 337191006645 dimer interface [polypeptide binding]; other site 337191006646 motif 1; other site 337191006647 active site 337191006648 motif 2; other site 337191006649 motif 3; other site 337191006650 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 337191006651 anticodon binding site; other site 337191006652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191006653 short chain dehydrogenase; Provisional; Region: PRK07825 337191006654 classical (c) SDRs; Region: SDR_c; cd05233 337191006655 NAD(P) binding site [chemical binding]; other site 337191006656 active site 337191006657 Bacterial protein of unknown function (DUF885); Region: DUF885; cl19872 337191006658 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 337191006659 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 337191006660 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 337191006661 dimer interface [polypeptide binding]; other site 337191006662 anticodon binding site; other site 337191006663 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 337191006664 homodimer interface [polypeptide binding]; other site 337191006665 motif 1; other site 337191006666 active site 337191006667 motif 2; other site 337191006668 GAD domain; Region: GAD; pfam02938 337191006669 motif 3; other site 337191006670 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 337191006671 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 337191006672 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 337191006673 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 337191006674 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448 337191006675 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl19824 337191006676 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 337191006677 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 337191006678 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 337191006679 Ecdysteroid kinase; Region: EcKinase; cl17738 337191006680 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 337191006681 recombination factor protein RarA; Reviewed; Region: PRK13342 337191006682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191006683 Walker A motif; other site 337191006684 ATP binding site [chemical binding]; other site 337191006685 Walker B motif; other site 337191006686 arginine finger; other site 337191006687 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 337191006688 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 337191006689 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 337191006690 motif 1; other site 337191006691 active site 337191006692 motif 2; other site 337191006693 motif 3; other site 337191006694 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 337191006695 DHHA1 domain; Region: DHHA1; pfam02272 337191006696 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 337191006697 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 337191006698 dimerization interface [polypeptide binding]; other site 337191006699 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 337191006700 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 337191006701 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 337191006702 NAD(P) binding pocket [chemical binding]; other site 337191006703 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 337191006704 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 337191006705 Tetramer interface [polypeptide binding]; other site 337191006706 active site 337191006707 FMN-binding site [chemical binding]; other site 337191006708 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 337191006709 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 337191006710 ADP binding site [chemical binding]; other site 337191006711 magnesium binding site [ion binding]; other site 337191006712 putative shikimate binding site; other site 337191006713 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 337191006714 active site 337191006715 dimer interface [polypeptide binding]; other site 337191006716 metal binding site [ion binding]; metal-binding site 337191006717 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 337191006718 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 337191006719 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 337191006720 active site 337191006721 elongation factor P; Validated; Region: PRK00529 337191006722 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 337191006723 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 337191006724 RNA binding site [nucleotide binding]; other site 337191006725 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 337191006726 RNA binding site [nucleotide binding]; other site 337191006727 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 337191006728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191006729 active site 337191006730 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 337191006731 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 337191006732 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 337191006733 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191006734 dihydroorotase; Validated; Region: pyrC; PRK09357 337191006735 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 337191006736 active site 337191006737 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 337191006738 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 337191006739 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 337191006740 catalytic site [active] 337191006741 subunit interface [polypeptide binding]; other site 337191006742 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 337191006743 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 337191006744 ATP-grasp domain; Region: ATP-grasp_4; cl17255 337191006745 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 337191006746 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 337191006747 ATP-grasp domain; Region: ATP-grasp_4; cl17255 337191006748 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 337191006749 IMP binding site; other site 337191006750 dimer interface [polypeptide binding]; other site 337191006751 interdomain contacts; other site 337191006752 partial ornithine binding site; other site 337191006753 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 337191006754 active site 337191006755 dimer interface [polypeptide binding]; other site 337191006756 Guanylate kinase; Region: Guanylate_kin; pfam00625 337191006757 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 337191006758 catalytic site [active] 337191006759 G-X2-G-X-G-K; other site 337191006760 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 337191006761 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 337191006762 Flavoprotein; Region: Flavoprotein; cl19190 337191006763 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 337191006764 S-adenosylmethionine synthetase; Validated; Region: PRK05250 337191006765 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 337191006766 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 337191006767 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 337191006768 primosome assembly protein PriA; Provisional; Region: PRK14873 337191006769 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 337191006770 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 337191006771 putative active site [active] 337191006772 substrate binding site [chemical binding]; other site 337191006773 putative cosubstrate binding site; other site 337191006774 catalytic site [active] 337191006775 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 337191006776 substrate binding site [chemical binding]; other site 337191006777 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 337191006778 putative RNA binding site [nucleotide binding]; other site 337191006779 16S rRNA methyltransferase B; Provisional; Region: PRK14902 337191006780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191006781 S-adenosylmethionine binding site [chemical binding]; other site 337191006782 RibD C-terminal domain; Region: RibD_C; cl17279 337191006783 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191006784 hydrophobic ligand binding site; other site 337191006785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191006786 putative DNA binding site [nucleotide binding]; other site 337191006787 putative Zn2+ binding site [ion binding]; other site 337191006788 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191006789 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191006790 active site 337191006791 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 337191006792 substrate binding site [chemical binding]; other site 337191006793 hexamer interface [polypeptide binding]; other site 337191006794 metal binding site [ion binding]; metal-binding site 337191006795 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 337191006796 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 337191006797 catalytic motif [active] 337191006798 Zn binding site [ion binding]; other site 337191006799 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 337191006800 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 337191006801 Lumazine binding domain; Region: Lum_binding; pfam00677 337191006802 Lumazine binding domain; Region: Lum_binding; pfam00677 337191006803 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 337191006804 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 337191006805 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 337191006806 dimerization interface [polypeptide binding]; other site 337191006807 active site 337191006808 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 337191006809 homopentamer interface [polypeptide binding]; other site 337191006810 active site 337191006811 Bacterial PH domain; Region: bPH_6; pfam10756 337191006812 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 337191006813 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 337191006814 GIY-YIG motif/motif A; other site 337191006815 active site 337191006816 catalytic site [active] 337191006817 putative DNA binding site [nucleotide binding]; other site 337191006818 metal binding site [ion binding]; metal-binding site 337191006819 UvrB/uvrC motif; Region: UVR; pfam02151 337191006820 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 337191006821 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 337191006822 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 337191006823 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 337191006824 phosphate binding site [ion binding]; other site 337191006825 putative substrate binding pocket [chemical binding]; other site 337191006826 dimer interface [polypeptide binding]; other site 337191006827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 337191006828 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 337191006829 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 337191006830 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 337191006831 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 337191006832 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 337191006833 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 337191006834 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 337191006835 substrate binding site [chemical binding]; other site 337191006836 hinge regions; other site 337191006837 ADP binding site [chemical binding]; other site 337191006838 catalytic site [active] 337191006839 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 337191006840 substrate binding site [chemical binding]; other site 337191006841 dimer interface [polypeptide binding]; other site 337191006842 catalytic triad [active] 337191006843 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 337191006844 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 337191006845 putative active site [active] 337191006846 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 337191006847 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 337191006848 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 337191006849 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 337191006850 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 337191006851 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 337191006852 putative active site [active] 337191006853 catalytic residue [active] 337191006854 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 337191006855 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 337191006856 TPP-binding site [chemical binding]; other site 337191006857 dimer interface [polypeptide binding]; other site 337191006858 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 337191006859 PYR/PP interface [polypeptide binding]; other site 337191006860 dimer interface [polypeptide binding]; other site 337191006861 TPP binding site [chemical binding]; other site 337191006862 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 337191006863 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 337191006864 putative active site [active] 337191006865 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 337191006866 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 337191006867 NADP binding site [chemical binding]; other site 337191006868 dimer interface [polypeptide binding]; other site 337191006869 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 337191006870 ABC-2 type transporter; Region: ABC2_membrane; cl17235 337191006871 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191006872 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 337191006873 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 337191006874 Walker A/P-loop; other site 337191006875 ATP binding site [chemical binding]; other site 337191006876 Q-loop/lid; other site 337191006877 ABC transporter signature motif; other site 337191006878 Walker B; other site 337191006879 D-loop; other site 337191006880 H-loop/switch region; other site 337191006881 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 337191006882 Predicted transcriptional regulator [Transcription]; Region: COG2345 337191006883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191006884 putative DNA binding site [nucleotide binding]; other site 337191006885 putative Zn2+ binding site [ion binding]; other site 337191006886 FeS assembly protein SufB; Region: sufB; TIGR01980 337191006887 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 337191006888 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 337191006889 FeS assembly protein SufD; Region: sufD; TIGR01981 337191006890 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 337191006891 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 337191006892 Walker A/P-loop; other site 337191006893 ATP binding site [chemical binding]; other site 337191006894 Q-loop/lid; other site 337191006895 ABC transporter signature motif; other site 337191006896 Walker B; other site 337191006897 D-loop; other site 337191006898 H-loop/switch region; other site 337191006899 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 337191006900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191006901 catalytic residue [active] 337191006902 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 337191006903 trimerization site [polypeptide binding]; other site 337191006904 active site 337191006905 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 337191006906 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 337191006907 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 337191006908 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 337191006909 oxyanion hole [active] 337191006910 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 337191006911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191006912 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 337191006913 classical (c) SDRs; Region: SDR_c; cd05233 337191006914 NAD(P) binding site [chemical binding]; other site 337191006915 active site 337191006916 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 337191006917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191006918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191006919 putative aminotransferase; Provisional; Region: PRK03321 337191006920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191006921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191006922 homodimer interface [polypeptide binding]; other site 337191006923 catalytic residue [active] 337191006924 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 337191006925 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 337191006926 active site 337191006927 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 337191006928 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 337191006929 PYR/PP interface [polypeptide binding]; other site 337191006930 dimer interface [polypeptide binding]; other site 337191006931 TPP binding site [chemical binding]; other site 337191006932 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 337191006933 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 337191006934 TPP-binding site [chemical binding]; other site 337191006935 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 337191006936 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 337191006937 acyl-activating enzyme (AAE) consensus motif; other site 337191006938 putative AMP binding site [chemical binding]; other site 337191006939 putative active site [active] 337191006940 putative CoA binding site [chemical binding]; other site 337191006941 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 337191006942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191006943 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 337191006944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191006945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191006946 aconitate hydratase; Validated; Region: PRK09277 337191006947 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 337191006948 substrate binding site [chemical binding]; other site 337191006949 ligand binding site [chemical binding]; other site 337191006950 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 337191006951 substrate binding site [chemical binding]; other site 337191006952 Coiled-coil receptor-binding R-domain of colicin E2; Region: E2R135; pfam11570 337191006953 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 337191006954 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 337191006955 NlpC/P60 family; Region: NLPC_P60; pfam00877 337191006956 MoxR-like ATPases [General function prediction only]; Region: COG0714 337191006957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191006958 Walker A motif; other site 337191006959 ATP binding site [chemical binding]; other site 337191006960 Walker B motif; other site 337191006961 arginine finger; other site 337191006962 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 337191006963 Protein of unknown function DUF58; Region: DUF58; pfam01882 337191006964 hypothetical protein; Provisional; Region: PRK13685 337191006965 von Willebrand factor type A domain; Region: VWA_2; pfam13519 337191006966 metal ion-dependent adhesion site (MIDAS); other site 337191006967 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 337191006968 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 337191006969 NAD(P) binding site [chemical binding]; other site 337191006970 homotetramer interface [polypeptide binding]; other site 337191006971 homodimer interface [polypeptide binding]; other site 337191006972 active site 337191006973 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 337191006974 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 337191006975 NAD(P) binding site [chemical binding]; other site 337191006976 active site 337191006977 ferrochelatase; Reviewed; Region: hemH; PRK00035 337191006978 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 337191006979 C-terminal domain interface [polypeptide binding]; other site 337191006980 active site 337191006981 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 337191006982 active site 337191006983 N-terminal domain interface [polypeptide binding]; other site 337191006984 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 337191006985 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 337191006986 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 337191006987 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 337191006988 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 337191006989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 337191006990 Uncharacterized conserved protein [Function unknown]; Region: COG0398 337191006991 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 337191006992 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 337191006993 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 337191006994 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 337191006995 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 337191006996 active site 337191006997 substrate binding site [chemical binding]; other site 337191006998 coenzyme B12 binding site [chemical binding]; other site 337191006999 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 337191007000 B12 binding site [chemical binding]; other site 337191007001 cobalt ligand [ion binding]; other site 337191007002 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 337191007003 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 337191007004 Walker A; other site 337191007005 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 337191007006 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 337191007007 active site 337191007008 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 337191007009 Peptidase family M23; Region: Peptidase_M23; pfam01551 337191007010 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 337191007011 Mechanosensitive ion channel; Region: MS_channel; pfam00924 337191007012 hypothetical protein; Provisional; Region: PRK07906 337191007013 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 337191007014 putative metal binding site [ion binding]; other site 337191007015 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 337191007016 substrate binding site [chemical binding]; other site 337191007017 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 337191007018 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 337191007019 quinone interaction residues [chemical binding]; other site 337191007020 active site 337191007021 catalytic residues [active] 337191007022 FMN binding site [chemical binding]; other site 337191007023 substrate binding site [chemical binding]; other site 337191007024 PQQ-like domain; Region: PQQ_2; pfam13360 337191007025 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 337191007026 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 337191007027 catalytic core [active] 337191007028 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 337191007029 conserved hypothetical protein; Region: TIGR03843 337191007030 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 337191007031 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 337191007032 active site 337191007033 HIGH motif; other site 337191007034 KMSKS motif; other site 337191007035 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 337191007036 tRNA binding surface [nucleotide binding]; other site 337191007037 anticodon binding site; other site 337191007038 PAC2 family; Region: PAC2; pfam09754 337191007039 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 337191007040 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 337191007041 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 337191007042 substrate binding pocket [chemical binding]; other site 337191007043 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 337191007044 B12 binding site [chemical binding]; other site 337191007045 cobalt ligand [ion binding]; other site 337191007046 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 337191007047 enoyl-CoA hydratase; Provisional; Region: PRK08259 337191007048 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191007049 substrate binding site [chemical binding]; other site 337191007050 oxyanion hole (OAH) forming residues; other site 337191007051 trimer interface [polypeptide binding]; other site 337191007052 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 337191007053 DHH family; Region: DHH; pfam01368 337191007054 DHHA2 domain; Region: DHHA2; pfam02833 337191007055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191007056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191007057 putative substrate translocation pore; other site 337191007058 Competence-damaged protein; Region: CinA; pfam02464 337191007059 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191007060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191007061 non-specific DNA binding site [nucleotide binding]; other site 337191007062 salt bridge; other site 337191007063 sequence-specific DNA binding site [nucleotide binding]; other site 337191007064 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 337191007065 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 337191007066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191007067 active site 337191007068 motif I; other site 337191007069 motif II; other site 337191007070 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 337191007071 homodimer interface [polypeptide binding]; other site 337191007072 putative metal binding site [ion binding]; other site 337191007073 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 337191007074 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 337191007075 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 337191007076 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 337191007077 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 337191007078 tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801 337191007079 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 337191007080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191007081 S-adenosylmethionine binding site [chemical binding]; other site 337191007082 proteasome ATPase; Region: pup_AAA; TIGR03689 337191007083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191007084 Walker A motif; other site 337191007085 ATP binding site [chemical binding]; other site 337191007086 Walker B motif; other site 337191007087 arginine finger; other site 337191007088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 337191007089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 337191007090 phosphopeptide binding site; other site 337191007091 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 337191007092 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 337191007093 phosphopeptide binding site; other site 337191007094 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 337191007095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191007096 Walker A/P-loop; other site 337191007097 ATP binding site [chemical binding]; other site 337191007098 Q-loop/lid; other site 337191007099 ABC transporter signature motif; other site 337191007100 Walker B; other site 337191007101 D-loop; other site 337191007102 H-loop/switch region; other site 337191007103 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 337191007104 ABC-2 type transporter; Region: ABC2_membrane; cl17235 337191007105 Domain of unknown function (DUF385); Region: DUF385; cl04387 337191007106 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 337191007107 putative homodimer interface [polypeptide binding]; other site 337191007108 putative active site pocket [active] 337191007109 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 337191007110 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 337191007111 Pup-like protein; Region: Pup; cl05289 337191007112 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 337191007113 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 337191007114 active site 337191007115 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 337191007116 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 337191007117 active site 337191007118 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 337191007119 Predicted transcriptional regulator [Transcription]; Region: COG2378 337191007120 WYL domain; Region: WYL; pfam13280 337191007121 WYL domain; Region: WYL; pfam13280 337191007122 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 337191007123 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 337191007124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191007125 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 337191007126 ATP binding site [chemical binding]; other site 337191007127 putative Mg++ binding site [ion binding]; other site 337191007128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191007129 nucleotide binding region [chemical binding]; other site 337191007130 ATP-binding site [chemical binding]; other site 337191007131 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 337191007132 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 337191007133 5'-3' exonuclease; Region: 53EXOc; smart00475 337191007134 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 337191007135 active site 337191007136 metal binding site 1 [ion binding]; metal-binding site 337191007137 putative 5' ssDNA interaction site; other site 337191007138 metal binding site 3; metal-binding site 337191007139 metal binding site 2 [ion binding]; metal-binding site 337191007140 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 337191007141 putative DNA binding site [nucleotide binding]; other site 337191007142 putative metal binding site [ion binding]; other site 337191007143 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 337191007144 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 337191007145 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 337191007146 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 337191007147 active site 337191007148 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 337191007149 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 337191007150 classical (c) SDRs; Region: SDR_c; cd05233 337191007151 NAD(P) binding site [chemical binding]; other site 337191007152 active site 337191007153 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 337191007154 active site 337191007155 putative homodimer interface [polypeptide binding]; other site 337191007156 SAM binding site [chemical binding]; other site 337191007157 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 337191007158 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 337191007159 active site 337191007160 homodimer interface [polypeptide binding]; other site 337191007161 SAM binding site [chemical binding]; other site 337191007162 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 337191007163 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 337191007164 active site 337191007165 SAM binding site [chemical binding]; other site 337191007166 homodimer interface [polypeptide binding]; other site 337191007167 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 337191007168 active site 337191007169 SAM binding site [chemical binding]; other site 337191007170 homodimer interface [polypeptide binding]; other site 337191007171 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 337191007172 precorrin-3B synthase; Region: CobG; TIGR02435 337191007173 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 337191007174 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 337191007175 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 337191007176 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 337191007177 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 337191007178 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191007179 active site 337191007180 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 337191007181 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 337191007182 putative active site [active] 337191007183 catalytic triad [active] 337191007184 putative dimer interface [polypeptide binding]; other site 337191007185 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 337191007186 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 337191007187 Ligand binding site; other site 337191007188 Putative Catalytic site; other site 337191007189 DXD motif; other site 337191007190 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 337191007191 hypothetical protein; Provisional; Region: PRK14013 337191007192 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 337191007193 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191007194 active site 337191007195 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 337191007196 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 337191007197 FAD dependent oxidoreductase; Region: DAO; pfam01266 337191007198 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 337191007199 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191007200 active site 337191007201 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 337191007202 dimer interface [polypeptide binding]; other site 337191007203 N-terminal domain interface [polypeptide binding]; other site 337191007204 sulfate 1 binding site; other site 337191007205 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 337191007206 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 337191007207 active site 337191007208 substrate binding site [chemical binding]; other site 337191007209 metal binding site [ion binding]; metal-binding site 337191007210 tellurium resistance terB-like protein; Region: terB_like; cl11965 337191007211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191007212 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 337191007213 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 337191007214 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 337191007215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191007216 Walker A/P-loop; other site 337191007217 ATP binding site [chemical binding]; other site 337191007218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191007219 ABC transporter signature motif; other site 337191007220 Walker B; other site 337191007221 D-loop; other site 337191007222 H-loop/switch region; other site 337191007223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191007224 Walker A/P-loop; other site 337191007225 ATP binding site [chemical binding]; other site 337191007226 Q-loop/lid; other site 337191007227 ABC transporter signature motif; other site 337191007228 Walker B; other site 337191007229 D-loop; other site 337191007230 H-loop/switch region; other site 337191007231 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191007232 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191007233 active site 337191007234 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 337191007235 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 337191007236 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 337191007237 putative active site [active] 337191007238 putative NTP binding site [chemical binding]; other site 337191007239 putative nucleic acid binding site [nucleotide binding]; other site 337191007240 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 337191007241 heme-binding site [chemical binding]; other site 337191007242 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 337191007243 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191007244 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 337191007245 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191007246 hydrophobic ligand binding site; other site 337191007247 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191007248 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191007249 SnoaL-like domain; Region: SnoaL_2; pfam12680 337191007250 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 337191007251 EamA-like transporter family; Region: EamA; pfam00892 337191007252 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 337191007253 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 337191007254 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 337191007255 active site 337191007256 catalytic triad [active] 337191007257 dimer interface [polypeptide binding]; other site 337191007258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191007259 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 337191007260 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 337191007261 dimerization interface [polypeptide binding]; other site 337191007262 ATP binding site [chemical binding]; other site 337191007263 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 337191007264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191007265 FeS/SAM binding site; other site 337191007266 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 337191007267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191007268 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 337191007269 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 337191007270 active site 337191007271 catalytic triad [active] 337191007272 dimer interface [polypeptide binding]; other site 337191007273 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 337191007274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191007275 Transposase; Region: DEDD_Tnp_IS110; pfam01548 337191007276 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191007277 ZIP Zinc transporter; Region: Zip; cl00437 337191007278 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 337191007279 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191007280 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191007281 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 337191007282 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 337191007283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 337191007284 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 337191007285 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 337191007286 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 337191007287 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 337191007288 Part of AAA domain; Region: AAA_19; pfam13245 337191007289 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 337191007290 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 337191007291 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 337191007292 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 337191007293 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 337191007294 active site 337191007295 GIY-YIG motif/motif A; other site 337191007296 catalytic site [active] 337191007297 metal binding site [ion binding]; metal-binding site 337191007298 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 337191007299 Part of AAA domain; Region: AAA_19; pfam13245 337191007300 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 337191007301 AAA domain; Region: AAA_12; pfam13087 337191007302 AAA domain; Region: AAA_11; pfam13086 337191007303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191007304 ATP binding site [chemical binding]; other site 337191007305 AAA domain; Region: AAA_12; pfam13087 337191007306 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 337191007307 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 337191007308 putative homodimer interface [polypeptide binding]; other site 337191007309 PLD-like domain; Region: PLDc_2; pfam13091 337191007310 putative active site [active] 337191007311 catalytic site [active] 337191007312 DEAD-like helicases superfamily; Region: DEXDc; smart00487 337191007313 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 337191007314 helicase superfamily c-terminal domain; Region: HELICc; smart00490 337191007315 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 337191007316 additional DNA contacts [nucleotide binding]; other site 337191007317 mismatch recognition site; other site 337191007318 active site 337191007319 zinc binding site [ion binding]; other site 337191007320 DNA intercalation site [nucleotide binding]; other site 337191007321 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 337191007322 PLD-like domain; Region: PLDc_2; pfam13091 337191007323 putative active site [active] 337191007324 catalytic site [active] 337191007325 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 337191007326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191007327 ATP-binding site [chemical binding]; other site 337191007328 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 337191007329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191007330 ATP binding site [chemical binding]; other site 337191007331 putative Mg++ binding site [ion binding]; other site 337191007332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191007333 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 337191007334 nucleotide binding region [chemical binding]; other site 337191007335 ATP-binding site [chemical binding]; other site 337191007336 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 337191007337 cofactor binding site; other site 337191007338 DNA binding site [nucleotide binding] 337191007339 substrate interaction site [chemical binding]; other site 337191007340 HNH endonuclease; Region: HNH_2; pfam13391 337191007341 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 337191007342 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 337191007343 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 337191007344 metal ion-dependent adhesion site (MIDAS); other site 337191007345 SnoaL-like domain; Region: SnoaL_4; pfam13577 337191007346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191007347 S-adenosylmethionine binding site [chemical binding]; other site 337191007348 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 337191007349 putative uracil binding site [chemical binding]; other site 337191007350 putative active site [active] 337191007351 SseB protein N-terminal domain; Region: SseB; pfam07179 337191007352 RAM signalling pathway protein; Region: SOG2; pfam10428 337191007353 Psoriasis susceptibility locus 2; Region: SPR1; pfam15356 337191007354 RHS Repeat; Region: RHS_repeat; pfam05593 337191007355 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 337191007356 RHS Repeat; Region: RHS_repeat; pfam05593 337191007357 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 337191007358 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 337191007359 RHS Repeat; Region: RHS_repeat; pfam05593 337191007360 RHS Repeat; Region: RHS_repeat; pfam05593 337191007361 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 337191007362 HEAT repeats; Region: HEAT_2; pfam13646 337191007363 proline/glycine betaine transporter; Provisional; Region: PRK10642 337191007364 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 337191007365 Peptidase family M23; Region: Peptidase_M23; pfam01551 337191007366 protease3; Provisional; Region: PRK15101 337191007367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191007368 dimerization interface [polypeptide binding]; other site 337191007369 putative DNA binding site [nucleotide binding]; other site 337191007370 putative Zn2+ binding site [ion binding]; other site 337191007371 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 337191007372 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 337191007373 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 337191007374 YCII-related domain; Region: YCII; cl00999 337191007375 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 337191007376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191007377 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 337191007378 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 337191007379 acyl-activating enzyme (AAE) consensus motif; other site 337191007380 putative AMP binding site [chemical binding]; other site 337191007381 putative active site [active] 337191007382 putative CoA binding site [chemical binding]; other site 337191007383 enoyl-CoA hydratase; Provisional; Region: PRK07509 337191007384 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191007385 substrate binding site [chemical binding]; other site 337191007386 oxyanion hole (OAH) forming residues; other site 337191007387 trimer interface [polypeptide binding]; other site 337191007388 UV excision repair protein Rad23; Region: rad23; TIGR00601 337191007389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 337191007390 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 337191007391 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 337191007392 catalytic residues [active] 337191007393 dimer interface [polypeptide binding]; other site 337191007394 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191007395 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 337191007396 FAD binding pocket [chemical binding]; other site 337191007397 FAD binding motif [chemical binding]; other site 337191007398 phosphate binding motif [ion binding]; other site 337191007399 beta-alpha-beta structure motif; other site 337191007400 NAD binding pocket [chemical binding]; other site 337191007401 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 337191007402 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 337191007403 Moco binding site; other site 337191007404 metal coordination site [ion binding]; other site 337191007405 Transcriptional regulator PadR-like family; Region: PadR; cl17335 337191007406 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191007407 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 337191007408 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 337191007409 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 337191007410 Walker A/P-loop; other site 337191007411 ATP binding site [chemical binding]; other site 337191007412 Q-loop/lid; other site 337191007413 ABC transporter signature motif; other site 337191007414 Walker B; other site 337191007415 D-loop; other site 337191007416 H-loop/switch region; other site 337191007417 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 337191007418 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 337191007419 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 337191007420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 337191007421 putative active site [active] 337191007422 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 337191007423 heme pocket [chemical binding]; other site 337191007424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 337191007425 putative active site [active] 337191007426 heme pocket [chemical binding]; other site 337191007427 PAS domain; Region: PAS; smart00091 337191007428 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 337191007429 metal binding site [ion binding]; metal-binding site 337191007430 active site 337191007431 I-site; other site 337191007432 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 337191007433 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 337191007434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191007435 putative substrate translocation pore; other site 337191007436 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 337191007437 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 337191007438 FMN binding site [chemical binding]; other site 337191007439 substrate binding site [chemical binding]; other site 337191007440 putative catalytic residue [active] 337191007441 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 337191007442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191007443 NAD(P) binding site [chemical binding]; other site 337191007444 active site 337191007445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191007446 salt bridge; other site 337191007447 non-specific DNA binding site [nucleotide binding]; other site 337191007448 sequence-specific DNA binding site [nucleotide binding]; other site 337191007449 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191007450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191007451 Predicted membrane protein [Function unknown]; Region: COG2259 337191007452 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 337191007453 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 337191007454 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 337191007455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191007456 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 337191007457 NAD(P) binding site [chemical binding]; other site 337191007458 active site 337191007459 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 337191007460 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 337191007461 Fe-S cluster binding site [ion binding]; other site 337191007462 active site 337191007463 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 337191007464 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 337191007465 NAD binding site [chemical binding]; other site 337191007466 catalytic Zn binding site [ion binding]; other site 337191007467 structural Zn binding site [ion binding]; other site 337191007468 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 337191007469 substrate binding site [chemical binding]; other site 337191007470 dimer interface [polypeptide binding]; other site 337191007471 ATP binding site [chemical binding]; other site 337191007472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191007473 FAD dependent oxidoreductase; Region: DAO; pfam01266 337191007474 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191007475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191007476 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 337191007477 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 337191007478 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 337191007479 conserved cys residue [active] 337191007480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191007481 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 337191007482 catalytic triad [active] 337191007483 conserved cis-peptide bond; other site 337191007484 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 337191007485 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 337191007486 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 337191007487 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 337191007488 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 337191007489 putative acyl-acceptor binding pocket; other site 337191007490 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 337191007491 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 337191007492 NAD binding site [chemical binding]; other site 337191007493 substrate binding site [chemical binding]; other site 337191007494 catalytic Zn binding site [ion binding]; other site 337191007495 structural Zn binding site [ion binding]; other site 337191007496 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 337191007497 hypothetical protein; Validated; Region: PRK00029 337191007498 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 337191007499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191007500 Coenzyme A binding pocket [chemical binding]; other site 337191007501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191007502 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191007503 salt bridge; other site 337191007504 non-specific DNA binding site [nucleotide binding]; other site 337191007505 sequence-specific DNA binding site [nucleotide binding]; other site 337191007506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191007507 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 337191007508 NAD(P) binding site [chemical binding]; other site 337191007509 active site 337191007510 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 337191007511 GTPase RsgA; Reviewed; Region: PRK01889 337191007512 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 337191007513 GTPase/Zn-binding domain interface [polypeptide binding]; other site 337191007514 GTP/Mg2+ binding site [chemical binding]; other site 337191007515 G4 box; other site 337191007516 G5 box; other site 337191007517 G1 box; other site 337191007518 Switch I region; other site 337191007519 G2 box; other site 337191007520 G3 box; other site 337191007521 Switch II region; other site 337191007522 AAA ATPase domain; Region: AAA_16; pfam13191 337191007523 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191007524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191007525 DNA binding residues [nucleotide binding] 337191007526 dimerization interface [polypeptide binding]; other site 337191007527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191007528 S-adenosylmethionine binding site [chemical binding]; other site 337191007529 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191007530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191007531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191007532 Walker A/P-loop; other site 337191007533 ATP binding site [chemical binding]; other site 337191007534 Q-loop/lid; other site 337191007535 ABC transporter signature motif; other site 337191007536 Walker B; other site 337191007537 D-loop; other site 337191007538 H-loop/switch region; other site 337191007539 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 337191007540 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 337191007541 putative NAD(P) binding site [chemical binding]; other site 337191007542 Amidase; Region: Amidase; cl11426 337191007543 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 337191007544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191007545 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 337191007546 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 337191007547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191007548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191007549 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 337191007550 NAD(P) binding site [chemical binding]; other site 337191007551 active site 337191007552 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 337191007553 NAD(P) binding site [chemical binding]; other site 337191007554 catalytic residues [active] 337191007555 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 337191007556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191007557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191007558 WHG domain; Region: WHG; pfam13305 337191007559 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191007560 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191007561 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 337191007562 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 337191007563 potential catalytic triad [active] 337191007564 conserved cys residue [active] 337191007565 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 337191007566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191007567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191007568 DNA binding residues [nucleotide binding] 337191007569 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 337191007570 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191007571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191007572 short chain dehydrogenase; Provisional; Region: PRK06180 337191007573 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 337191007574 NADP binding site [chemical binding]; other site 337191007575 active site 337191007576 steroid binding site; other site 337191007577 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 337191007578 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191007579 DNA binding residues [nucleotide binding] 337191007580 drug binding residues [chemical binding]; other site 337191007581 dimer interface [polypeptide binding]; other site 337191007582 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 337191007583 Domain of unknown function (DUF4436); Region: DUF4436; pfam14494 337191007584 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191007585 pyruvate kinase; Provisional; Region: PRK06247 337191007586 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 337191007587 active site 337191007588 domain interfaces; other site 337191007589 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 337191007590 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191007591 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 337191007592 NAD(P) binding site [chemical binding]; other site 337191007593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 337191007594 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 337191007595 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 337191007596 dimer interface [polypeptide binding]; other site 337191007597 catalytic residue [active] 337191007598 metal binding site [ion binding]; metal-binding site 337191007599 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 337191007600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191007601 DNA-binding site [nucleotide binding]; DNA binding site 337191007602 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 337191007603 Predicted membrane protein [Function unknown]; Region: COG2259 337191007604 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 337191007605 putative hydrophobic ligand binding site [chemical binding]; other site 337191007606 short chain dehydrogenase; Provisional; Region: PRK05866 337191007607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191007608 NAD(P) binding site [chemical binding]; other site 337191007609 active site 337191007610 PE-PPE domain; Region: PE-PPE; pfam08237 337191007611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 337191007612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191007613 Coenzyme A binding pocket [chemical binding]; other site 337191007614 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191007615 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 337191007616 putative DNA binding site [nucleotide binding]; other site 337191007617 putative Zn2+ binding site [ion binding]; other site 337191007618 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 337191007619 MMPL family; Region: MMPL; pfam03176 337191007620 MMPL family; Region: MMPL; cl14618 337191007621 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 337191007622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191007623 Walker A/P-loop; other site 337191007624 ATP binding site [chemical binding]; other site 337191007625 Q-loop/lid; other site 337191007626 ABC transporter signature motif; other site 337191007627 Walker B; other site 337191007628 D-loop; other site 337191007629 H-loop/switch region; other site 337191007630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191007631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191007632 Walker A/P-loop; other site 337191007633 ATP binding site [chemical binding]; other site 337191007634 Q-loop/lid; other site 337191007635 ABC transporter signature motif; other site 337191007636 Walker B; other site 337191007637 D-loop; other site 337191007638 H-loop/switch region; other site 337191007639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 337191007640 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 337191007641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191007642 dimer interface [polypeptide binding]; other site 337191007643 conserved gate region; other site 337191007644 putative PBP binding loops; other site 337191007645 ABC-ATPase subunit interface; other site 337191007646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 337191007647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191007648 dimer interface [polypeptide binding]; other site 337191007649 conserved gate region; other site 337191007650 putative PBP binding loops; other site 337191007651 ABC-ATPase subunit interface; other site 337191007652 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191007653 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 337191007654 hypothetical protein; Provisional; Region: PRK01346 337191007655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191007656 Sterol carrier protein domain; Region: SCP2_2; pfam13530 337191007657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191007658 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 337191007659 active site 337191007660 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191007661 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191007662 Amino acid permease; Region: AA_permease; pfam00324 337191007663 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 337191007664 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 337191007665 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191007666 dimer interface [polypeptide binding]; other site 337191007667 active site 337191007668 Predicted transcriptional regulators [Transcription]; Region: COG1733 337191007669 putative DNA binding site [nucleotide binding]; other site 337191007670 dimerization interface [polypeptide binding]; other site 337191007671 putative Zn2+ binding site [ion binding]; other site 337191007672 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191007673 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 337191007674 NAD(P) binding site [chemical binding]; other site 337191007675 catalytic residues [active] 337191007676 Putative esterase; Region: Esterase; pfam00756 337191007677 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191007678 glutamate dehydrogenase; Provisional; Region: PRK09414 337191007679 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 337191007680 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 337191007681 NAD(P) binding site [chemical binding]; other site 337191007682 A new structural DNA glycosylase; Region: AlkD_like; cd06561 337191007683 active site 337191007684 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 337191007685 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 337191007686 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 337191007687 putative active site [active] 337191007688 putative metal binding site [ion binding]; other site 337191007689 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191007690 active site 337191007691 metal binding site [ion binding]; metal-binding site 337191007692 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 337191007693 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 337191007694 metal binding site 2 [ion binding]; metal-binding site 337191007695 putative DNA binding helix; other site 337191007696 metal binding site 1 [ion binding]; metal-binding site 337191007697 dimer interface [polypeptide binding]; other site 337191007698 structural Zn2+ binding site [ion binding]; other site 337191007699 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 337191007700 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 337191007701 dimer interface [polypeptide binding]; other site 337191007702 active site 337191007703 heme binding site [chemical binding]; other site 337191007704 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 337191007705 hypothetical protein; Validated; Region: PRK07198 337191007706 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 337191007707 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 337191007708 dimerization interface [polypeptide binding]; other site 337191007709 active site 337191007710 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 337191007711 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191007712 active site 337191007713 CAAX protease self-immunity; Region: Abi; pfam02517 337191007714 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 337191007715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191007716 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191007717 NAD(P) binding site [chemical binding]; other site 337191007718 active site 337191007719 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 337191007720 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 337191007721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191007722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191007723 active site 337191007724 phosphorylation site [posttranslational modification] 337191007725 intermolecular recognition site; other site 337191007726 dimerization interface [polypeptide binding]; other site 337191007727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191007728 DNA binding residues [nucleotide binding] 337191007729 dimerization interface [polypeptide binding]; other site 337191007730 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 337191007731 Histidine kinase; Region: HisKA_3; pfam07730 337191007732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191007733 ATP binding site [chemical binding]; other site 337191007734 Mg2+ binding site [ion binding]; other site 337191007735 G-X-G motif; other site 337191007736 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 337191007737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191007738 Walker A/P-loop; other site 337191007739 ATP binding site [chemical binding]; other site 337191007740 Q-loop/lid; other site 337191007741 ABC transporter signature motif; other site 337191007742 Walker B; other site 337191007743 D-loop; other site 337191007744 H-loop/switch region; other site 337191007745 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 337191007746 Predicted membrane protein [Function unknown]; Region: COG4425 337191007747 Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420 337191007748 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 337191007749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 337191007750 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 337191007751 NADP+ binding site [chemical binding]; other site 337191007752 folate binding site [chemical binding]; other site 337191007753 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191007754 CoenzymeA binding site [chemical binding]; other site 337191007755 subunit interaction site [polypeptide binding]; other site 337191007756 PHB binding site; other site 337191007757 enoyl-CoA hydratase; Provisional; Region: PRK06142 337191007758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191007759 substrate binding site [chemical binding]; other site 337191007760 oxyanion hole (OAH) forming residues; other site 337191007761 trimer interface [polypeptide binding]; other site 337191007762 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 337191007763 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 337191007764 nucleotide binding site [chemical binding]; other site 337191007765 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 337191007766 heat shock protein 90; Provisional; Region: PRK05218 337191007767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191007768 ATP binding site [chemical binding]; other site 337191007769 Mg2+ binding site [ion binding]; other site 337191007770 G-X-G motif; other site 337191007771 Hsp90 protein; Region: HSP90; pfam00183 337191007772 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 337191007773 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 337191007774 AAA domain; Region: AAA_30; pfam13604 337191007775 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 337191007776 Part of AAA domain; Region: AAA_19; pfam13245 337191007777 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 337191007778 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 337191007779 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 337191007780 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 337191007781 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 337191007782 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 337191007783 active site 337191007784 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 337191007785 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 337191007786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191007787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191007788 UreD urease accessory protein; Region: UreD; cl00530 337191007789 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191007790 UreF; Region: UreF; cl19817 337191007791 urease subunit alpha; Reviewed; Region: ureC; PRK13206 337191007792 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 337191007793 subunit interactions [polypeptide binding]; other site 337191007794 active site 337191007795 flap region; other site 337191007796 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 337191007797 gamma-beta subunit interface [polypeptide binding]; other site 337191007798 alpha-beta subunit interface [polypeptide binding]; other site 337191007799 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 337191007800 alpha-gamma subunit interface [polypeptide binding]; other site 337191007801 beta-gamma subunit interface [polypeptide binding]; other site 337191007802 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191007803 CoenzymeA binding site [chemical binding]; other site 337191007804 subunit interaction site [polypeptide binding]; other site 337191007805 PHB binding site; other site 337191007806 Penicillinase repressor; Region: Penicillinase_R; cl17580 337191007807 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 337191007808 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 337191007809 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 337191007810 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 337191007811 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 337191007812 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 337191007813 active site 337191007814 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 337191007815 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 337191007816 Domain of unknown function DUF21; Region: DUF21; pfam01595 337191007817 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 337191007818 Transporter associated domain; Region: CorC_HlyC; pfam03471 337191007819 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 337191007820 Domain of unknown function DUF21; Region: DUF21; pfam01595 337191007821 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 337191007822 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 337191007823 active site 337191007824 glycine dehydrogenase; Provisional; Region: PRK05367 337191007825 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 337191007826 tetramer interface [polypeptide binding]; other site 337191007827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191007828 catalytic residue [active] 337191007829 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 337191007830 tetramer interface [polypeptide binding]; other site 337191007831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191007832 catalytic residue [active] 337191007833 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 337191007834 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191007835 DNA binding residues [nucleotide binding] 337191007836 putative dimer interface [polypeptide binding]; other site 337191007837 Bifunctional nuclease; Region: DNase-RNase; pfam02577 337191007838 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 337191007839 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191007840 DNA binding residues [nucleotide binding] 337191007841 dimer interface [polypeptide binding]; other site 337191007842 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 337191007843 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 337191007844 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 337191007845 phosphopeptide binding site; other site 337191007846 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 337191007847 lipoyl attachment site [posttranslational modification]; other site 337191007848 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 337191007849 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 337191007850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191007851 ATP binding site [chemical binding]; other site 337191007852 putative Mg++ binding site [ion binding]; other site 337191007853 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 337191007854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191007855 nucleotide binding region [chemical binding]; other site 337191007856 ATP-binding site [chemical binding]; other site 337191007857 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 337191007858 META domain; Region: META; pfam03724 337191007859 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 337191007860 malate dehydrogenase; Provisional; Region: PRK05442 337191007861 NAD(P) binding site [chemical binding]; other site 337191007862 LDH/MDH dimer interface [polypeptide binding]; other site 337191007863 substrate binding site [chemical binding]; other site 337191007864 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 337191007865 Protein of unknown function (DUF503); Region: DUF503; pfam04456 337191007866 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 337191007867 active site 337191007868 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191007869 active site 337191007870 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 337191007871 DNA binding site [nucleotide binding] 337191007872 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 337191007873 Predicted ATPase [General function prediction only]; Region: COG3899 337191007874 AAA ATPase domain; Region: AAA_16; pfam13191 337191007875 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 337191007876 FAD binding domain; Region: FAD_binding_4; pfam01565 337191007877 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 337191007878 hypothetical protein; Provisional; Region: PRK06184 337191007879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191007880 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 337191007881 Beta-lactamase; Region: Beta-lactamase; pfam00144 337191007882 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 337191007883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191007884 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 337191007885 Walker A/P-loop; other site 337191007886 ATP binding site [chemical binding]; other site 337191007887 Q-loop/lid; other site 337191007888 ABC transporter signature motif; other site 337191007889 Walker B; other site 337191007890 D-loop; other site 337191007891 H-loop/switch region; other site 337191007892 ABC-2 type transporter; Region: ABC2_membrane; cl17235 337191007893 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191007894 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 337191007895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191007896 pyruvate dehydrogenase; Provisional; Region: PRK09124 337191007897 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 337191007898 PYR/PP interface [polypeptide binding]; other site 337191007899 dimer interface [polypeptide binding]; other site 337191007900 tetramer interface [polypeptide binding]; other site 337191007901 TPP binding site [chemical binding]; other site 337191007902 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 337191007903 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 337191007904 TPP-binding site [chemical binding]; other site 337191007905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191007906 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 337191007907 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191007908 active site 2 [active] 337191007909 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191007910 active site 2 [active] 337191007911 active site 1 [active] 337191007912 Domain of unknown function (DUF385); Region: DUF385; pfam04075 337191007913 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 337191007914 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 337191007915 active site 337191007916 DNA binding site [nucleotide binding] 337191007917 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191007918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191007919 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 337191007920 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 337191007921 catalytic residues [active] 337191007922 catalytic nucleophile [active] 337191007923 Presynaptic Site I dimer interface [polypeptide binding]; other site 337191007924 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 337191007925 Synaptic Flat tetramer interface [polypeptide binding]; other site 337191007926 Synaptic Site I dimer interface [polypeptide binding]; other site 337191007927 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 337191007928 DNA-binding interface [nucleotide binding]; DNA binding site 337191007929 Chorismate mutase type II; Region: CM_2; cl00693 337191007930 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 337191007931 Glutamine amidotransferase class-I; Region: GATase; pfam00117 337191007932 glutamine binding [chemical binding]; other site 337191007933 catalytic triad [active] 337191007934 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 337191007935 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 337191007936 chorismate binding enzyme; Region: Chorismate_bind; cl10555 337191007937 prephenate dehydrogenase; Provisional; Region: PRK06444 337191007938 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 337191007939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191007940 Coenzyme A binding pocket [chemical binding]; other site 337191007941 AAA-like domain; Region: AAA_10; pfam12846 337191007942 Zonular occludens toxin (Zot); Region: Zot; cl17485 337191007943 GTP-binding protein Der; Reviewed; Region: PRK03003 337191007944 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 337191007945 G1 box; other site 337191007946 GTP/Mg2+ binding site [chemical binding]; other site 337191007947 Switch I region; other site 337191007948 G2 box; other site 337191007949 Switch II region; other site 337191007950 G3 box; other site 337191007951 G4 box; other site 337191007952 G5 box; other site 337191007953 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 337191007954 G1 box; other site 337191007955 GTP/Mg2+ binding site [chemical binding]; other site 337191007956 Switch I region; other site 337191007957 G2 box; other site 337191007958 G3 box; other site 337191007959 Switch II region; other site 337191007960 G4 box; other site 337191007961 G5 box; other site 337191007962 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 337191007963 cytidylate kinase; Provisional; Region: cmk; PRK00023 337191007964 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 337191007965 CMP-binding site; other site 337191007966 The sites determining sugar specificity; other site 337191007967 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 337191007968 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 337191007969 RNA binding surface [nucleotide binding]; other site 337191007970 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 337191007971 active site 337191007972 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 337191007973 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 337191007974 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 337191007975 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 337191007976 P-loop; other site 337191007977 Magnesium ion binding site [ion binding]; other site 337191007978 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 337191007979 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 337191007980 active site 337191007981 Int/Topo IB signature motif; other site 337191007982 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 337191007983 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 337191007984 dimer interface [polypeptide binding]; other site 337191007985 ADP-ribose binding site [chemical binding]; other site 337191007986 active site 337191007987 nudix motif; other site 337191007988 metal binding site [ion binding]; metal-binding site 337191007989 CTP synthetase; Validated; Region: pyrG; PRK05380 337191007990 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 337191007991 Catalytic site [active] 337191007992 active site 337191007993 UTP binding site [chemical binding]; other site 337191007994 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 337191007995 active site 337191007996 putative oxyanion hole; other site 337191007997 catalytic triad [active] 337191007998 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 337191007999 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 337191008000 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 337191008001 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 337191008002 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 337191008003 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 337191008004 Walker A/P-loop; other site 337191008005 ATP binding site [chemical binding]; other site 337191008006 Q-loop/lid; other site 337191008007 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 337191008008 ABC transporter signature motif; other site 337191008009 Walker B; other site 337191008010 D-loop; other site 337191008011 H-loop/switch region; other site 337191008012 ATP-NAD kinase; Region: NAD_kinase; cl01255 337191008013 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 337191008014 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 337191008015 RNA binding surface [nucleotide binding]; other site 337191008016 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 337191008017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191008018 S-adenosylmethionine binding site [chemical binding]; other site 337191008019 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 337191008020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191008021 active site 337191008022 motif I; other site 337191008023 motif II; other site 337191008024 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 337191008025 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 337191008026 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 337191008027 active site 337191008028 HIGH motif; other site 337191008029 dimer interface [polypeptide binding]; other site 337191008030 KMSKS motif; other site 337191008031 S4 RNA-binding domain; Region: S4; smart00363 337191008032 Trm112p-like protein; Region: Trm112p; cl01066 337191008033 acyl-CoA synthetase; Validated; Region: PRK07868 337191008034 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191008035 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191008036 acyl-activating enzyme (AAE) consensus motif; other site 337191008037 AMP binding site [chemical binding]; other site 337191008038 active site 337191008039 CoA binding site [chemical binding]; other site 337191008040 argininosuccinate lyase; Provisional; Region: PRK00855 337191008041 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 337191008042 active sites [active] 337191008043 tetramer interface [polypeptide binding]; other site 337191008044 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 337191008045 ANP binding site [chemical binding]; other site 337191008046 Substrate Binding Site II [chemical binding]; other site 337191008047 Substrate Binding Site I [chemical binding]; other site 337191008048 arginine repressor; Provisional; Region: PRK03341 337191008049 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 337191008050 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 337191008051 ornithine carbamoyltransferase; Provisional; Region: PRK00779 337191008052 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 337191008053 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 337191008054 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 337191008055 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 337191008056 inhibitor-cofactor binding pocket; inhibition site 337191008057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191008058 catalytic residue [active] 337191008059 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 337191008060 feedback inhibition sensing region; other site 337191008061 homohexameric interface [polypeptide binding]; other site 337191008062 nucleotide binding site [chemical binding]; other site 337191008063 N-acetyl-L-glutamate binding site [chemical binding]; other site 337191008064 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 337191008065 heterotetramer interface [polypeptide binding]; other site 337191008066 active site pocket [active] 337191008067 cleavage site 337191008068 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 337191008069 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 337191008070 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 337191008071 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 337191008072 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 337191008073 putative tRNA-binding site [nucleotide binding]; other site 337191008074 B3/4 domain; Region: B3_4; pfam03483 337191008075 tRNA synthetase B5 domain; Region: B5; smart00874 337191008076 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 337191008077 dimer interface [polypeptide binding]; other site 337191008078 motif 1; other site 337191008079 motif 3; other site 337191008080 motif 2; other site 337191008081 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 337191008082 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 337191008083 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 337191008084 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 337191008085 dimer interface [polypeptide binding]; other site 337191008086 motif 1; other site 337191008087 active site 337191008088 motif 2; other site 337191008089 motif 3; other site 337191008090 Acyltransferase family; Region: Acyl_transf_3; cl19154 337191008091 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 337191008092 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 337191008093 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 337191008094 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 337191008095 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 337191008096 RNA binding site [nucleotide binding]; other site 337191008097 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 337191008098 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 337191008099 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 337191008100 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 337191008101 23S rRNA binding site [nucleotide binding]; other site 337191008102 L21 binding site [polypeptide binding]; other site 337191008103 L13 binding site [polypeptide binding]; other site 337191008104 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 337191008105 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 337191008106 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 337191008107 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 337191008108 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 337191008109 Zn binding site [ion binding]; other site 337191008110 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 337191008111 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 337191008112 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 337191008113 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 337191008114 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 337191008115 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 337191008116 Predicted membrane protein [Function unknown]; Region: COG2259 337191008117 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 337191008118 Part of AAA domain; Region: AAA_19; pfam13245 337191008119 PhoH-like protein; Region: PhoH; cl17668 337191008120 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 337191008121 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191008122 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191008123 acyl-activating enzyme (AAE) consensus motif; other site 337191008124 AMP binding site [chemical binding]; other site 337191008125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008126 Condensation domain; Region: Condensation; pfam00668 337191008127 peptide synthase; Provisional; Region: PRK12467 337191008128 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191008129 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191008130 acyl-activating enzyme (AAE) consensus motif; other site 337191008131 AMP binding site [chemical binding]; other site 337191008132 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008133 Condensation domain; Region: Condensation; cl19241 337191008134 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191008135 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191008136 acyl-activating enzyme (AAE) consensus motif; other site 337191008137 AMP binding site [chemical binding]; other site 337191008138 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008139 Condensation domain; Region: Condensation; cl19241 337191008140 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 337191008141 Condensation domain; Region: Condensation; cl19241 337191008142 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191008143 acyl-activating enzyme (AAE) consensus motif; other site 337191008144 AMP binding site [chemical binding]; other site 337191008145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008146 Condensation domain; Region: Condensation; pfam00668 337191008147 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191008148 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191008149 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191008150 acyl-activating enzyme (AAE) consensus motif; other site 337191008151 AMP binding site [chemical binding]; other site 337191008152 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008153 Condensation domain; Region: Condensation; pfam00668 337191008154 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191008155 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191008156 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191008157 acyl-activating enzyme (AAE) consensus motif; other site 337191008158 AMP binding site [chemical binding]; other site 337191008159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008160 Condensation domain; Region: Condensation; cl19241 337191008161 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191008162 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191008163 CoA binding site [chemical binding]; other site 337191008164 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008165 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191008166 Condensation domain; Region: Condensation; cl19241 337191008167 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191008168 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191008169 acyl-activating enzyme (AAE) consensus motif; other site 337191008170 AMP binding site [chemical binding]; other site 337191008171 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008172 Condensation domain; Region: Condensation; pfam00668 337191008173 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191008174 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191008175 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191008176 acyl-activating enzyme (AAE) consensus motif; other site 337191008177 AMP binding site [chemical binding]; other site 337191008178 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191008179 Condensation domain; Region: Condensation; pfam00668 337191008180 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191008181 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 337191008182 active site 337191008183 catalytic residues [active] 337191008184 metal binding site [ion binding]; metal-binding site 337191008185 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191008186 Ligand Binding Site [chemical binding]; other site 337191008187 excinuclease ABC subunit B; Provisional; Region: PRK05298 337191008188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191008189 ATP binding site [chemical binding]; other site 337191008190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191008191 nucleotide binding region [chemical binding]; other site 337191008192 ATP-binding site [chemical binding]; other site 337191008193 Ultra-violet resistance protein B; Region: UvrB; pfam12344 337191008194 UvrB/uvrC motif; Region: UVR; pfam02151 337191008195 Protein of unknown function (DUF402); Region: DUF402; cl00979 337191008196 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 337191008197 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 337191008198 CoA-binding site [chemical binding]; other site 337191008199 ATP-binding [chemical binding]; other site 337191008200 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 337191008201 classical (c) SDRs; Region: SDR_c; cd05233 337191008202 NAD(P) binding site [chemical binding]; other site 337191008203 active site 337191008204 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191008205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191008206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191008207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191008208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191008209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191008210 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 337191008211 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 337191008212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191008213 ATP binding site [chemical binding]; other site 337191008214 putative Mg++ binding site [ion binding]; other site 337191008215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191008216 nucleotide binding region [chemical binding]; other site 337191008217 ATP-binding site [chemical binding]; other site 337191008218 SWIM zinc finger; Region: SWIM; cl19527 337191008219 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 337191008220 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 337191008221 RNA binding site [nucleotide binding]; other site 337191008222 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 337191008223 RNA binding site [nucleotide binding]; other site 337191008224 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 337191008225 RNA binding site [nucleotide binding]; other site 337191008226 S1 RNA binding domain; Region: S1; pfam00575 337191008227 RNA binding site [nucleotide binding]; other site 337191008228 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 337191008229 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 337191008230 active site 337191008231 catalytic residues [active] 337191008232 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191008233 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191008234 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191008235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191008236 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 337191008237 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 337191008238 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 337191008239 active site 337191008240 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 337191008241 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 337191008242 Ligand binding site; other site 337191008243 Putative Catalytic site; other site 337191008244 DXD motif; other site 337191008245 Putative methyltransferase; Region: Methyltransf_4; cl17290 337191008246 Methyltransferase domain; Region: Methyltransf_31; pfam13847 337191008247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191008248 S-adenosylmethionine binding site [chemical binding]; other site 337191008249 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 337191008250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 337191008251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191008252 S-adenosylmethionine binding site [chemical binding]; other site 337191008253 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 337191008254 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 337191008255 Walker A/P-loop; other site 337191008256 ATP binding site [chemical binding]; other site 337191008257 Q-loop/lid; other site 337191008258 ABC transporter signature motif; other site 337191008259 Walker B; other site 337191008260 D-loop; other site 337191008261 H-loop/switch region; other site 337191008262 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 337191008263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191008264 dimer interface [polypeptide binding]; other site 337191008265 conserved gate region; other site 337191008266 putative PBP binding loops; other site 337191008267 ABC-ATPase subunit interface; other site 337191008268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 337191008269 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 337191008270 substrate binding pocket [chemical binding]; other site 337191008271 membrane-bound complex binding site; other site 337191008272 hinge residues; other site 337191008273 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 337191008274 DNA polymerase I; Provisional; Region: PRK05755 337191008275 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 337191008276 active site 337191008277 metal binding site 1 [ion binding]; metal-binding site 337191008278 putative 5' ssDNA interaction site; other site 337191008279 metal binding site 3; metal-binding site 337191008280 metal binding site 2 [ion binding]; metal-binding site 337191008281 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 337191008282 putative DNA binding site [nucleotide binding]; other site 337191008283 putative metal binding site [ion binding]; other site 337191008284 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 337191008285 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 337191008286 active site 337191008287 DNA binding site [nucleotide binding] 337191008288 catalytic site [active] 337191008289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191008290 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 337191008291 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 337191008292 TM-ABC transporter signature motif; other site 337191008293 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 337191008294 TM-ABC transporter signature motif; other site 337191008295 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 337191008296 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 337191008297 Walker A/P-loop; other site 337191008298 ATP binding site [chemical binding]; other site 337191008299 Q-loop/lid; other site 337191008300 ABC transporter signature motif; other site 337191008301 Walker B; other site 337191008302 D-loop; other site 337191008303 H-loop/switch region; other site 337191008304 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 337191008305 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 337191008306 Walker A/P-loop; other site 337191008307 ATP binding site [chemical binding]; other site 337191008308 Q-loop/lid; other site 337191008309 ABC transporter signature motif; other site 337191008310 Walker B; other site 337191008311 D-loop; other site 337191008312 H-loop/switch region; other site 337191008313 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 337191008314 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 337191008315 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 337191008316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191008317 active site 337191008318 phosphorylation site [posttranslational modification] 337191008319 intermolecular recognition site; other site 337191008320 dimerization interface [polypeptide binding]; other site 337191008321 ANTAR domain; Region: ANTAR; pfam03861 337191008322 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191008323 Amidohydrolase; Region: Amidohydro_2; pfam04909 337191008324 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 337191008325 DUF35 OB-fold domain; Region: DUF35; pfam01796 337191008326 lipid-transfer protein; Provisional; Region: PRK07855 337191008327 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 337191008328 active site 337191008329 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 337191008330 putative ligand binding site [chemical binding]; other site 337191008331 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 337191008332 TM-ABC transporter signature motif; other site 337191008333 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 337191008334 TM-ABC transporter signature motif; other site 337191008335 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 337191008336 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 337191008337 Walker A/P-loop; other site 337191008338 ATP binding site [chemical binding]; other site 337191008339 Q-loop/lid; other site 337191008340 ABC transporter signature motif; other site 337191008341 Walker B; other site 337191008342 D-loop; other site 337191008343 H-loop/switch region; other site 337191008344 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 337191008345 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 337191008346 Walker A/P-loop; other site 337191008347 ATP binding site [chemical binding]; other site 337191008348 Q-loop/lid; other site 337191008349 ABC transporter signature motif; other site 337191008350 Walker B; other site 337191008351 D-loop; other site 337191008352 H-loop/switch region; other site 337191008353 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 337191008354 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 337191008355 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 337191008356 acyl-CoA synthetase; Provisional; Region: PRK13391 337191008357 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191008358 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 337191008359 acyl-activating enzyme (AAE) consensus motif; other site 337191008360 acyl-activating enzyme (AAE) consensus motif; other site 337191008361 putative AMP binding site [chemical binding]; other site 337191008362 putative active site [active] 337191008363 putative CoA binding site [chemical binding]; other site 337191008364 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191008365 acyl-activating enzyme (AAE) consensus motif; other site 337191008366 active site 337191008367 AMP binding site [chemical binding]; other site 337191008368 CoA binding site [chemical binding]; other site 337191008369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191008370 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 337191008371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008372 active site 337191008373 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008374 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 337191008375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008376 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 337191008377 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 337191008378 FMN binding site [chemical binding]; other site 337191008379 substrate binding site [chemical binding]; other site 337191008380 putative catalytic residue [active] 337191008381 enoyl-CoA hydratase; Provisional; Region: PRK06190 337191008382 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191008383 substrate binding site [chemical binding]; other site 337191008384 oxyanion hole (OAH) forming residues; other site 337191008385 trimer interface [polypeptide binding]; other site 337191008386 enoyl-CoA hydratase; Provisional; Region: PRK08252 337191008387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191008388 substrate binding site [chemical binding]; other site 337191008389 oxyanion hole (OAH) forming residues; other site 337191008390 trimer interface [polypeptide binding]; other site 337191008391 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 337191008392 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191008393 dimer interface [polypeptide binding]; other site 337191008394 active site 337191008395 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008396 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008397 active site 337191008398 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191008399 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 337191008400 acyl-activating enzyme (AAE) consensus motif; other site 337191008401 AMP binding site [chemical binding]; other site 337191008402 active site 337191008403 CoA binding site [chemical binding]; other site 337191008404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008406 active site 337191008407 enoyl-CoA hydratase; Provisional; Region: PRK07509 337191008408 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191008409 substrate binding site [chemical binding]; other site 337191008410 oxyanion hole (OAH) forming residues; other site 337191008411 trimer interface [polypeptide binding]; other site 337191008412 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008413 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008414 active site 337191008415 Transcriptional regulators [Transcription]; Region: FadR; COG2186 337191008416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191008417 DNA-binding site [nucleotide binding]; DNA binding site 337191008418 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 337191008419 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 337191008420 active site 337191008421 catalytic site [active] 337191008422 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191008423 active site 2 [active] 337191008424 active site 1 [active] 337191008425 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 337191008426 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191008427 acyl-activating enzyme (AAE) consensus motif; other site 337191008428 AMP binding site [chemical binding]; other site 337191008429 active site 337191008430 CoA binding site [chemical binding]; other site 337191008431 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 337191008432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191008433 NAD(P) binding site [chemical binding]; other site 337191008434 active site 337191008435 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 337191008436 active site 337191008437 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 337191008438 catalytic triad [active] 337191008439 dimer interface [polypeptide binding]; other site 337191008440 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 337191008441 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191008442 active site 2 [active] 337191008443 active site 1 [active] 337191008444 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191008445 active site 2 [active] 337191008446 active site 1 [active] 337191008447 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191008448 active site 337191008449 CoA-transferase family III; Region: CoA_transf_3; cl19215 337191008450 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 337191008451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191008452 substrate binding site [chemical binding]; other site 337191008453 oxyanion hole (OAH) forming residues; other site 337191008454 trimer interface [polypeptide binding]; other site 337191008455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191008456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191008457 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 337191008458 NAD(P) binding site [chemical binding]; other site 337191008459 catalytic residues [active] 337191008460 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 337191008461 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 337191008462 catalytic Zn binding site [ion binding]; other site 337191008463 NAD binding site [chemical binding]; other site 337191008464 structural Zn binding site [ion binding]; other site 337191008465 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 337191008466 CoA binding domain; Region: CoA_binding_2; pfam13380 337191008467 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 337191008468 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 337191008469 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 337191008470 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 337191008471 active site 337191008472 enoyl-CoA hydratase; Provisional; Region: PRK06494 337191008473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191008474 substrate binding site [chemical binding]; other site 337191008475 oxyanion hole (OAH) forming residues; other site 337191008476 trimer interface [polypeptide binding]; other site 337191008477 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 337191008478 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 337191008479 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191008480 classical (c) SDRs; Region: SDR_c; cd05233 337191008481 NAD(P) binding site [chemical binding]; other site 337191008482 active site 337191008483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191008484 Predicted membrane protein [Function unknown]; Region: COG2259 337191008485 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 337191008486 active site 337191008487 substrate binding site [chemical binding]; other site 337191008488 ATP binding site [chemical binding]; other site 337191008489 Phosphotransferase enzyme family; Region: APH; pfam01636 337191008490 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191008491 classical (c) SDRs; Region: SDR_c; cd05233 337191008492 NAD(P) binding site [chemical binding]; other site 337191008493 active site 337191008494 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 337191008495 NAD binding site [chemical binding]; other site 337191008496 catalytic residues [active] 337191008497 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 337191008498 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191008499 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 337191008500 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 337191008501 Walker A/P-loop; other site 337191008502 ATP binding site [chemical binding]; other site 337191008503 Q-loop/lid; other site 337191008504 ABC transporter signature motif; other site 337191008505 Walker B; other site 337191008506 D-loop; other site 337191008507 H-loop/switch region; other site 337191008508 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 337191008509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191008510 Walker A/P-loop; other site 337191008511 ATP binding site [chemical binding]; other site 337191008512 Q-loop/lid; other site 337191008513 ABC transporter signature motif; other site 337191008514 Walker B; other site 337191008515 D-loop; other site 337191008516 H-loop/switch region; other site 337191008517 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 337191008518 TM-ABC transporter signature motif; other site 337191008519 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 337191008520 TM-ABC transporter signature motif; other site 337191008521 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 337191008522 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 337191008523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191008524 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191008525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191008526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191008527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191008528 putative substrate translocation pore; other site 337191008529 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 337191008530 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 337191008531 4Fe-4S binding domain; Region: Fer4; pfam00037 337191008532 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 337191008533 ferredoxin-NADP+ reductase; Region: PLN02852 337191008534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191008535 short chain dehydrogenase; Provisional; Region: PRK08278 337191008536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191008537 NAD(P) binding site [chemical binding]; other site 337191008538 active site 337191008539 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 337191008540 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 337191008541 DctM-like transporters; Region: DctM; pfam06808 337191008542 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 337191008543 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191008544 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191008545 Predicted membrane protein [Function unknown]; Region: COG2259 337191008546 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 337191008547 NAD(P) binding site [chemical binding]; other site 337191008548 catalytic residues [active] 337191008549 Putative cyclase; Region: Cyclase; pfam04199 337191008550 Putative cyclase; Region: Cyclase; cl00814 337191008551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008552 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008553 active site 337191008554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008555 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 337191008556 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 337191008558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191008559 Amidohydrolase; Region: Amidohydro_2; pfam04909 337191008560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191008561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191008562 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191008563 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 337191008564 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 337191008565 NAD binding site [chemical binding]; other site 337191008566 catalytic Zn binding site [ion binding]; other site 337191008567 substrate binding site [chemical binding]; other site 337191008568 structural Zn binding site [ion binding]; other site 337191008569 Putative cyclase; Region: Cyclase; pfam04199 337191008570 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 337191008571 NAD(P) binding site [chemical binding]; other site 337191008572 catalytic residues [active] 337191008573 lipid-transfer protein; Provisional; Region: PRK07855 337191008574 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 337191008575 active site 337191008576 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 337191008577 DUF35 OB-fold domain; Region: DUF35; pfam01796 337191008578 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191008579 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 337191008580 dimer interface [polypeptide binding]; other site 337191008581 active site 337191008582 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191008583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191008584 NAD(P) binding site [chemical binding]; other site 337191008585 active site 337191008586 acyl-CoA synthetase; Validated; Region: PRK08162 337191008587 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 337191008588 acyl-activating enzyme (AAE) consensus motif; other site 337191008589 putative active site [active] 337191008590 AMP binding site [chemical binding]; other site 337191008591 putative CoA binding site [chemical binding]; other site 337191008592 enoyl-CoA hydratase; Provisional; Region: PRK08252 337191008593 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191008594 substrate binding site [chemical binding]; other site 337191008595 oxyanion hole (OAH) forming residues; other site 337191008596 trimer interface [polypeptide binding]; other site 337191008597 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191008598 classical (c) SDRs; Region: SDR_c; cd05233 337191008599 NAD(P) binding site [chemical binding]; other site 337191008600 active site 337191008601 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 337191008602 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 337191008603 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 337191008604 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 337191008605 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 337191008606 active site 337191008607 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191008608 active site 2 [active] 337191008609 active site 1 [active] 337191008610 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191008611 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191008612 active site 2 [active] 337191008613 active site 1 [active] 337191008614 Transcriptional regulators [Transcription]; Region: FadR; COG2186 337191008615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191008616 DNA-binding site [nucleotide binding]; DNA binding site 337191008617 FCD domain; Region: FCD; pfam07729 337191008618 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 337191008619 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 337191008620 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 337191008621 acyl-activating enzyme (AAE) consensus motif; other site 337191008622 putative AMP binding site [chemical binding]; other site 337191008623 putative active site [active] 337191008624 putative CoA binding site [chemical binding]; other site 337191008625 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008626 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 337191008627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008628 active site 337191008629 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 337191008630 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191008631 substrate binding site [chemical binding]; other site 337191008632 oxyanion hole (OAH) forming residues; other site 337191008633 trimer interface [polypeptide binding]; other site 337191008634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008636 active site 337191008637 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191008640 non-specific DNA binding site [nucleotide binding]; other site 337191008641 salt bridge; other site 337191008642 sequence-specific DNA binding site [nucleotide binding]; other site 337191008643 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 337191008644 cofactor binding site; other site 337191008645 DNA binding site [nucleotide binding] 337191008646 substrate interaction site [chemical binding]; other site 337191008647 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191008648 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 337191008649 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 337191008650 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191008651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191008652 salt bridge; other site 337191008653 non-specific DNA binding site [nucleotide binding]; other site 337191008654 sequence-specific DNA binding site [nucleotide binding]; other site 337191008655 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 337191008656 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191008657 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 337191008658 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 337191008659 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 337191008660 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191008661 active site 337191008662 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191008663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191008664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191008665 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191008666 active site 337191008667 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 337191008668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191008669 catalytic loop [active] 337191008670 iron binding site [ion binding]; other site 337191008671 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 337191008672 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 337191008673 L-aspartate oxidase; Provisional; Region: PRK06175 337191008674 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 337191008675 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 337191008676 Pirin-related protein [General function prediction only]; Region: COG1741 337191008677 Pirin; Region: Pirin; pfam02678 337191008678 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 337191008679 amphipathic channel; other site 337191008680 Asn-Pro-Ala signature motifs; other site 337191008681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191008682 Transposase; Region: DEDD_Tnp_IS110; pfam01548 337191008683 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191008684 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 337191008685 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 337191008686 putative ligand binding site [chemical binding]; other site 337191008687 NAD binding site [chemical binding]; other site 337191008688 dimer interface [polypeptide binding]; other site 337191008689 putative catalytic site [active] 337191008690 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 337191008691 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 337191008692 active site 337191008693 tetramer interface [polypeptide binding]; other site 337191008694 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 337191008695 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 337191008696 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191008697 Walker A/P-loop; other site 337191008698 ATP binding site [chemical binding]; other site 337191008699 Q-loop/lid; other site 337191008700 ABC transporter signature motif; other site 337191008701 Walker B; other site 337191008702 D-loop; other site 337191008703 H-loop/switch region; other site 337191008704 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191008705 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 337191008706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191008707 Walker A/P-loop; other site 337191008708 ATP binding site [chemical binding]; other site 337191008709 Q-loop/lid; other site 337191008710 ABC transporter signature motif; other site 337191008711 Walker B; other site 337191008712 D-loop; other site 337191008713 H-loop/switch region; other site 337191008714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191008715 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 337191008716 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 337191008717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191008718 dimer interface [polypeptide binding]; other site 337191008719 conserved gate region; other site 337191008720 putative PBP binding loops; other site 337191008721 ABC-ATPase subunit interface; other site 337191008722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 337191008723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191008724 dimer interface [polypeptide binding]; other site 337191008725 conserved gate region; other site 337191008726 putative PBP binding loops; other site 337191008727 ABC-ATPase subunit interface; other site 337191008728 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191008729 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 337191008730 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 337191008731 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 337191008732 putative ligand binding site [chemical binding]; other site 337191008733 NAD binding site [chemical binding]; other site 337191008734 catalytic site [active] 337191008735 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191008736 Ligand Binding Site [chemical binding]; other site 337191008737 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 337191008738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191008739 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 337191008740 putative dimerization interface [polypeptide binding]; other site 337191008741 putative substrate binding pocket [chemical binding]; other site 337191008742 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 337191008743 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 337191008744 active site 337191008745 tetramer interface [polypeptide binding]; other site 337191008746 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 337191008747 catalytic residue [active] 337191008748 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 337191008749 dimer interface [polypeptide binding]; other site 337191008750 NADP binding site [chemical binding]; other site 337191008751 catalytic residues [active] 337191008752 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191008753 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191008754 active site 337191008755 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 337191008756 Di-iron ligands [ion binding]; other site 337191008757 Transposase, Mutator family; Region: Transposase_mut; cl19537 337191008758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 337191008759 Rubredoxin [Energy production and conversion]; Region: COG1773 337191008760 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 337191008761 iron binding site [ion binding]; other site 337191008762 Rubredoxin [Energy production and conversion]; Region: COG1773 337191008763 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 337191008764 iron binding site [ion binding]; other site 337191008765 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 337191008766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191008767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191008768 Reductase C-terminal; Region: Reductase_C; pfam14759 337191008769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191008770 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 337191008771 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 337191008772 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 337191008773 putative active site [active] 337191008774 putative active site [active] 337191008775 catalytic site [active] 337191008776 catalytic site [active] 337191008777 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 337191008778 putative active site [active] 337191008779 catalytic site [active] 337191008780 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 337191008781 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 337191008782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 337191008783 guanine deaminase; Provisional; Region: PRK09228 337191008784 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191008785 active site 337191008786 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 337191008787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 337191008788 SEC-C motif; Region: SEC-C; cl19389 337191008789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 337191008790 Dodecin; Region: Dodecin; pfam07311 337191008791 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191008792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191008793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191008794 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 337191008795 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 337191008796 Short C-terminal domain; Region: SHOCT; pfam09851 337191008797 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 337191008798 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 337191008799 acyl-activating enzyme (AAE) consensus motif; other site 337191008800 putative AMP binding site [chemical binding]; other site 337191008801 putative active site [active] 337191008802 putative CoA binding site [chemical binding]; other site 337191008803 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 337191008804 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 337191008805 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 337191008806 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 337191008807 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 337191008808 active site 337191008809 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 337191008810 catalytic triad [active] 337191008811 dimer interface [polypeptide binding]; other site 337191008812 pyruvate kinase; Provisional; Region: PRK06247 337191008813 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 337191008814 domain interfaces; other site 337191008815 active site 337191008816 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 337191008817 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 337191008818 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 337191008819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191008820 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 337191008821 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 337191008822 active site 337191008823 dimer interface [polypeptide binding]; other site 337191008824 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 337191008825 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 337191008826 active site 337191008827 FMN binding site [chemical binding]; other site 337191008828 substrate binding site [chemical binding]; other site 337191008829 3Fe-4S cluster binding site [ion binding]; other site 337191008830 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 337191008831 domain interface; other site 337191008832 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 337191008833 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 337191008834 Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string...; Region: H4; cl00074 337191008835 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 337191008836 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 337191008837 substrate binding site [chemical binding]; other site 337191008838 active site 337191008839 catalytic residues [active] 337191008840 heterodimer interface [polypeptide binding]; other site 337191008841 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 337191008842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191008843 catalytic residue [active] 337191008844 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 337191008845 active site 337191008846 ribulose/triose binding site [chemical binding]; other site 337191008847 phosphate binding site [ion binding]; other site 337191008848 substrate (anthranilate) binding pocket [chemical binding]; other site 337191008849 product (indole) binding pocket [chemical binding]; other site 337191008850 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 337191008851 anthranilate synthase component I; Provisional; Region: PRK13571 337191008852 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 337191008853 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 337191008854 Tautomerase enzyme; Region: Tautomerase; pfam01361 337191008855 active site 1 [active] 337191008856 dimer interface [polypeptide binding]; other site 337191008857 hexamer interface [polypeptide binding]; other site 337191008858 active site 2 [active] 337191008859 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 337191008860 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 337191008861 substrate binding site [chemical binding]; other site 337191008862 glutamase interaction surface [polypeptide binding]; other site 337191008863 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 337191008864 active site 337191008865 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 337191008866 catalytic residues [active] 337191008867 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 337191008868 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 337191008869 putative active site [active] 337191008870 oxyanion strand; other site 337191008871 catalytic triad [active] 337191008872 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 337191008873 putative active site pocket [active] 337191008874 4-fold oligomerization interface [polypeptide binding]; other site 337191008875 metal binding residues [ion binding]; metal-binding site 337191008876 3-fold/trimer interface [polypeptide binding]; other site 337191008877 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 337191008878 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191008879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191008880 homodimer interface [polypeptide binding]; other site 337191008881 catalytic residue [active] 337191008882 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 337191008883 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 337191008884 NAD binding site [chemical binding]; other site 337191008885 dimerization interface [polypeptide binding]; other site 337191008886 product binding site; other site 337191008887 substrate binding site [chemical binding]; other site 337191008888 zinc binding site [ion binding]; other site 337191008889 catalytic residues [active] 337191008890 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 337191008891 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 337191008892 dimerization interface [polypeptide binding]; other site 337191008893 active site 337191008894 quinolinate synthetase; Provisional; Region: PRK09375 337191008895 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 337191008896 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191008897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191008898 non-specific DNA binding site [nucleotide binding]; other site 337191008899 salt bridge; other site 337191008900 sequence-specific DNA binding site [nucleotide binding]; other site 337191008901 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 337191008902 active site 337191008903 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 337191008904 nudix motif; other site 337191008905 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 337191008906 biotin synthase; Validated; Region: PRK06256 337191008907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191008908 FeS/SAM binding site; other site 337191008909 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 337191008910 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 337191008911 AAA domain; Region: AAA_26; pfam13500 337191008912 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 337191008913 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 337191008914 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191008915 catalytic residue [active] 337191008916 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 337191008917 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 337191008918 inhibitor-cofactor binding pocket; inhibition site 337191008919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191008920 catalytic residue [active] 337191008921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191008922 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 337191008923 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 337191008924 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 337191008925 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 337191008926 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 337191008927 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 337191008928 active site 337191008929 catalytic site [active] 337191008930 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 337191008931 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 337191008932 active site 337191008933 catalytic site [active] 337191008934 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191008935 mce related protein; Region: MCE; pfam02470 337191008936 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191008937 mce related protein; Region: MCE; pfam02470 337191008938 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191008939 mce related protein; Region: MCE; pfam02470 337191008940 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191008941 mce related protein; Region: MCE; pfam02470 337191008942 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191008943 mce related protein; Region: MCE; pfam02470 337191008944 mce related protein; Region: MCE; pfam02470 337191008945 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 337191008946 Permease; Region: Permease; pfam02405 337191008947 Permease; Region: Permease; pfam02405 337191008948 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 337191008949 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 337191008950 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 337191008951 catalytic site [active] 337191008952 active site 337191008953 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 337191008954 threonine dehydratase; Validated; Region: PRK08639 337191008955 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 337191008956 tetramer interface [polypeptide binding]; other site 337191008957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191008958 catalytic residue [active] 337191008959 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 337191008960 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 337191008961 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 337191008962 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 337191008963 active site 337191008964 PHP Thumb interface [polypeptide binding]; other site 337191008965 metal binding site [ion binding]; metal-binding site 337191008966 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 337191008967 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 337191008968 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 337191008969 generic binding surface II; other site 337191008970 generic binding surface I; other site 337191008971 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191008972 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191008973 active site 337191008974 ATP binding site [chemical binding]; other site 337191008975 substrate binding site [chemical binding]; other site 337191008976 activation loop (A-loop); other site 337191008977 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 337191008978 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 337191008979 active site 337191008980 lipoprotein signal peptidase; Provisional; Region: PRK14764 337191008981 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 337191008982 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 337191008983 active site 337191008984 homotetramer interface [polypeptide binding]; other site 337191008985 homodimer interface [polypeptide binding]; other site 337191008986 DNA polymerase IV; Provisional; Region: PRK03348 337191008987 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 337191008988 active site 337191008989 DNA binding site [nucleotide binding] 337191008990 Domain of unknown function (DUF385); Region: DUF385; cl04387 337191008991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191008992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191008993 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 337191008994 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 337191008995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 337191008996 active site 337191008997 HIGH motif; other site 337191008998 nucleotide binding site [chemical binding]; other site 337191008999 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 337191009000 active site 337191009001 KMSKS motif; other site 337191009002 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 337191009003 tRNA binding surface [nucleotide binding]; other site 337191009004 anticodon binding site; other site 337191009005 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 337191009006 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 337191009007 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 337191009008 Flagellar assembly protein FliH; Region: FliH; cl19405 337191009009 Predicted integral membrane protein [Function unknown]; Region: COG0762 337191009010 Protein of unknown function (DUF552); Region: DUF552; cl00775 337191009011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 337191009012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 337191009013 catalytic residue [active] 337191009014 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 337191009015 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 337191009016 nucleotide binding site [chemical binding]; other site 337191009017 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 337191009018 SulA interaction site; other site 337191009019 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 337191009020 Cell division protein FtsQ; Region: FtsQ; pfam03799 337191009021 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 337191009022 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 337191009023 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 337191009024 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 337191009025 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 337191009026 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 337191009027 active site 337191009028 homodimer interface [polypeptide binding]; other site 337191009029 cell division protein FtsW; Region: ftsW; TIGR02614 337191009030 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 337191009031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 337191009032 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 337191009033 Mg++ binding site [ion binding]; other site 337191009034 putative catalytic motif [active] 337191009035 putative substrate binding site [chemical binding]; other site 337191009036 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 337191009037 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 337191009038 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 337191009039 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 337191009040 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 337191009041 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 337191009042 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 337191009043 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 337191009044 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 337191009045 MraW methylase family; Region: Methyltransf_5; cl17771 337191009046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191009047 S-adenosylmethionine binding site [chemical binding]; other site 337191009048 cell division protein MraZ; Reviewed; Region: PRK00326 337191009049 MraZ protein; Region: MraZ; pfam02381 337191009050 MraZ protein; Region: MraZ; pfam02381 337191009051 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 337191009052 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 337191009053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191009054 Coenzyme A binding pocket [chemical binding]; other site 337191009055 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 337191009056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191009057 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 337191009058 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 337191009059 FAD binding site [chemical binding]; other site 337191009060 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 337191009061 substrate binding pocket [chemical binding]; other site 337191009062 chain length determination region; other site 337191009063 substrate-Mg2+ binding site; other site 337191009064 catalytic residues [active] 337191009065 aspartate-rich region 1; other site 337191009066 active site lid residues [active] 337191009067 aspartate-rich region 2; other site 337191009068 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 337191009069 Helix-turn-helix domain; Region: HTH_17; pfam12728 337191009070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191009071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 337191009072 active site 337191009073 ATP binding site [chemical binding]; other site 337191009074 substrate binding site [chemical binding]; other site 337191009075 activation loop (A-loop); other site 337191009076 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 337191009077 Putative tRNA pseudouridine synthase; Provisional; Region: PLN03078 337191009078 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 337191009079 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 337191009080 active site 337191009081 8-oxo-dGMP binding site [chemical binding]; other site 337191009082 nudix motif; other site 337191009083 metal binding site [ion binding]; metal-binding site 337191009084 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 337191009085 putative acyl-acceptor binding pocket; other site 337191009086 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 337191009087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 337191009088 nucleotide binding site [chemical binding]; other site 337191009089 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 337191009090 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191009091 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 337191009092 putative hydrophobic ligand binding site [chemical binding]; other site 337191009093 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 337191009094 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 337191009095 acyl-activating enzyme (AAE) consensus motif; other site 337191009096 putative AMP binding site [chemical binding]; other site 337191009097 putative active site [active] 337191009098 putative CoA binding site [chemical binding]; other site 337191009099 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 337191009100 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191009101 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 337191009102 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 337191009103 NlpC/P60 family; Region: NLPC_P60; pfam00877 337191009104 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 337191009105 NlpC/P60 family; Region: NLPC_P60; pfam00877 337191009106 hypothetical protein; Validated; Region: PRK07883 337191009107 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 337191009108 active site 337191009109 catalytic site [active] 337191009110 substrate binding site [chemical binding]; other site 337191009111 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 337191009112 GIY-YIG motif/motif A; other site 337191009113 active site 337191009114 catalytic site [active] 337191009115 putative DNA binding site [nucleotide binding]; other site 337191009116 metal binding site [ion binding]; metal-binding site 337191009117 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191009118 AsnC family; Region: AsnC_trans_reg; pfam01037 337191009119 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 337191009120 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 337191009121 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 337191009122 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 337191009123 Subunit I/III interface [polypeptide binding]; other site 337191009124 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 337191009125 Cytochrome c; Region: Cytochrom_C; cl11414 337191009126 Cytochrome c; Region: Cytochrom_C; pfam00034 337191009127 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 337191009128 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 337191009129 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 337191009130 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 337191009131 iron-sulfur cluster [ion binding]; other site 337191009132 [2Fe-2S] cluster binding site [ion binding]; other site 337191009133 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 337191009134 heme bH binding site [chemical binding]; other site 337191009135 Qi binding site; other site 337191009136 intrachain domain interface; other site 337191009137 heme bL binding site [chemical binding]; other site 337191009138 interchain domain interface [polypeptide binding]; other site 337191009139 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 337191009140 Qo binding site; other site 337191009141 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 337191009142 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 337191009143 active site 337191009144 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 337191009145 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 337191009146 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 337191009147 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 337191009148 Cupredoxin superfamily; Region: Cupredoxin; cl19115 337191009149 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 337191009150 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 337191009151 active site 337191009152 dimer interface [polypeptide binding]; other site 337191009153 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 337191009154 Ligand Binding Site [chemical binding]; other site 337191009155 Molecular Tunnel; other site 337191009156 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191009157 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 337191009158 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 337191009159 NAD binding site [chemical binding]; other site 337191009160 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 337191009161 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 337191009162 substrate binding site [chemical binding]; other site 337191009163 ATP binding site [chemical binding]; other site 337191009164 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 337191009165 Glycerate kinase family; Region: Gly_kinase; cl00841 337191009166 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 337191009167 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 337191009168 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 337191009169 putative dimer interface [polypeptide binding]; other site 337191009170 active site pocket [active] 337191009171 putative cataytic base [active] 337191009172 cobalamin synthase; Reviewed; Region: cobS; PRK00235 337191009173 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 337191009174 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 337191009175 homodimer interface [polypeptide binding]; other site 337191009176 substrate-cofactor binding pocket; other site 337191009177 catalytic residue [active] 337191009178 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 337191009179 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 337191009180 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 337191009181 multifunctional aminopeptidase A; Provisional; Region: PRK00913 337191009182 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 337191009183 interface (dimer of trimers) [polypeptide binding]; other site 337191009184 Substrate-binding/catalytic site; other site 337191009185 Zn-binding sites [ion binding]; other site 337191009186 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 337191009187 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 337191009188 E3 interaction surface; other site 337191009189 lipoyl attachment site [posttranslational modification]; other site 337191009190 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 337191009191 E3 interaction surface; other site 337191009192 lipoyl attachment site [posttranslational modification]; other site 337191009193 e3 binding domain; Region: E3_binding; pfam02817 337191009194 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 337191009195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191009196 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 337191009197 NAD(P) binding site [chemical binding]; other site 337191009198 active site 337191009199 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 337191009200 lipoyl synthase; Provisional; Region: PRK05481 337191009201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191009202 FeS/SAM binding site; other site 337191009203 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 337191009204 RDD family; Region: RDD; pfam06271 337191009205 glutamine synthetase, type I; Region: GlnA; TIGR00653 337191009206 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 337191009207 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 337191009208 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 337191009209 heme binding pocket [chemical binding]; other site 337191009210 heme ligand [chemical binding]; other site 337191009211 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 337191009212 putative catalytic site [active] 337191009213 putative metal binding site [ion binding]; other site 337191009214 putative phosphate binding site [ion binding]; other site 337191009215 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 337191009216 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 337191009217 metal binding triad; other site 337191009218 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 337191009219 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 337191009220 metal binding triad; other site 337191009221 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 337191009222 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 337191009223 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 337191009224 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 337191009225 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 337191009226 oligomerization interface [polypeptide binding]; other site 337191009227 active site 337191009228 metal binding site [ion binding]; metal-binding site 337191009229 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191009230 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 337191009231 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 337191009232 putative active site; other site 337191009233 putative metal binding residues [ion binding]; other site 337191009234 signature motif; other site 337191009235 putative triphosphate binding site [ion binding]; other site 337191009236 CHAD domain; Region: CHAD; pfam05235 337191009237 RNB domain; Region: RNB; pfam00773 337191009238 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 337191009239 catalytic core [active] 337191009240 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 337191009241 Putative zinc ribbon domain; Region: DUF164; pfam02591 337191009242 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 337191009243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 337191009244 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 337191009245 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191009246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191009247 homodimer interface [polypeptide binding]; other site 337191009248 catalytic residue [active] 337191009249 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 337191009250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191009251 motif II; other site 337191009252 Low molecular weight phosphatase family; Region: LMWPc; cd00115 337191009253 active site 337191009254 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 337191009255 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 337191009256 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 337191009257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191009258 S-adenosylmethionine binding site [chemical binding]; other site 337191009259 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191009260 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191009261 active site 337191009262 ATP binding site [chemical binding]; other site 337191009263 substrate binding site [chemical binding]; other site 337191009264 activation loop (A-loop); other site 337191009265 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 337191009266 active site 337191009267 Integrase core domain; Region: rve; pfam00665 337191009268 Integrase core domain; Region: rve_3; pfam13683 337191009269 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 337191009270 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 337191009271 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191009272 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191009273 active site 337191009274 ATP binding site [chemical binding]; other site 337191009275 substrate binding site [chemical binding]; other site 337191009276 activation loop (A-loop); other site 337191009277 Predicted transcriptional regulator [Transcription]; Region: COG2378 337191009278 HTH domain; Region: HTH_11; pfam08279 337191009279 WYL domain; Region: WYL; pfam13280 337191009280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191009281 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 337191009282 NAD(P) binding site [chemical binding]; other site 337191009283 active site 337191009284 CAAX protease self-immunity; Region: Abi; pfam02517 337191009285 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 337191009286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191009287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191009288 DNA binding residues [nucleotide binding] 337191009289 Asp23 family; Region: Asp23; pfam03780 337191009290 Asp23 family; Region: Asp23; pfam03780 337191009291 CsbD-like; Region: CsbD; pfam05532 337191009292 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 337191009293 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 337191009294 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 337191009295 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 337191009296 dimer interface [polypeptide binding]; other site 337191009297 catalytic triad [active] 337191009298 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 337191009299 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 337191009300 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 337191009301 dimer interface [polypeptide binding]; other site 337191009302 TPP-binding site [chemical binding]; other site 337191009303 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 337191009304 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 337191009305 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 337191009306 acyl carrier protein; Provisional; Region: acpP; PRK00982 337191009307 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 337191009308 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 337191009309 dimer interface [polypeptide binding]; other site 337191009310 active site 337191009311 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 337191009312 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 337191009313 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 337191009314 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 337191009315 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 337191009316 Beta-lactamase; Region: Beta-lactamase; pfam00144 337191009317 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 337191009318 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 337191009319 NAD binding site [chemical binding]; other site 337191009320 catalytic Zn binding site [ion binding]; other site 337191009321 substrate binding site [chemical binding]; other site 337191009322 structural Zn binding site [ion binding]; other site 337191009323 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 337191009324 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 337191009325 acyl-activating enzyme (AAE) consensus motif; other site 337191009326 putative AMP binding site [chemical binding]; other site 337191009327 putative active site [active] 337191009328 putative CoA binding site [chemical binding]; other site 337191009329 enoyl-CoA hydratase; Provisional; Region: PRK06688 337191009330 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191009331 substrate binding site [chemical binding]; other site 337191009332 oxyanion hole (OAH) forming residues; other site 337191009333 trimer interface [polypeptide binding]; other site 337191009334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191009335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191009336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191009337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191009338 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 337191009339 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 337191009340 tetramer interface [polypeptide binding]; other site 337191009341 active site 337191009342 Mg2+/Mn2+ binding site [ion binding]; other site 337191009343 Integrase core domain; Region: rve; pfam00665 337191009344 Integrase core domain; Region: rve_3; pfam13683 337191009345 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 337191009346 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 337191009347 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 337191009348 NADP binding site [chemical binding]; other site 337191009349 Predicted transcriptional regulators [Transcription]; Region: COG1733 337191009350 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 337191009351 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 337191009352 catalytic triad [active] 337191009353 conserved cis-peptide bond; other site 337191009354 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 337191009355 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 337191009356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191009357 DNA-binding site [nucleotide binding]; DNA binding site 337191009358 FCD domain; Region: FCD; pfam07729 337191009359 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 337191009360 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 337191009361 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 337191009362 active site 337191009363 metal binding site [ion binding]; metal-binding site 337191009364 interdomain interaction site; other site 337191009365 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 337191009366 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 337191009367 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 337191009368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 337191009369 Zn2+ binding site [ion binding]; other site 337191009370 Mg2+ binding site [ion binding]; other site 337191009371 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 337191009372 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 337191009373 RNA-binding motif; other site 337191009374 DNA-binding site [nucleotide binding]; DNA binding site 337191009375 glycyl-tRNA synthetase; Provisional; Region: PRK04173 337191009376 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 337191009377 dimer interface [polypeptide binding]; other site 337191009378 motif 1; other site 337191009379 active site 337191009380 motif 2; other site 337191009381 motif 3; other site 337191009382 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 337191009383 anticodon binding site; other site 337191009384 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 337191009385 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 337191009386 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 337191009387 PA/protease or protease-like domain interface [polypeptide binding]; other site 337191009388 active site 337191009389 metal binding site [ion binding]; metal-binding site 337191009390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191009391 dimerization interface [polypeptide binding]; other site 337191009392 putative DNA binding site [nucleotide binding]; other site 337191009393 putative Zn2+ binding site [ion binding]; other site 337191009394 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 337191009395 metal binding site 2 [ion binding]; metal-binding site 337191009396 putative DNA binding helix; other site 337191009397 metal binding site 1 [ion binding]; metal-binding site 337191009398 dimer interface [polypeptide binding]; other site 337191009399 structural Zn2+ binding site [ion binding]; other site 337191009400 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 337191009401 active site 337191009402 dimer interface [polypeptide binding]; other site 337191009403 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 337191009404 Recombination protein O N terminal; Region: RecO_N; pfam11967 337191009405 Recombination protein O C terminal; Region: RecO_C; pfam02565 337191009406 Pyruvate kinase, barrel domain; Region: PK; cl17342 337191009407 pyruvate kinase; Validated; Region: PRK08187 337191009408 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 337191009409 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 337191009410 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 337191009411 GTPase Era; Reviewed; Region: era; PRK00089 337191009412 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 337191009413 G1 box; other site 337191009414 GTP/Mg2+ binding site [chemical binding]; other site 337191009415 Switch I region; other site 337191009416 G2 box; other site 337191009417 Switch II region; other site 337191009418 G3 box; other site 337191009419 G4 box; other site 337191009420 G5 box; other site 337191009421 KH domain; Region: KH_2; pfam07650 337191009422 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 337191009423 active site 337191009424 Zn binding site [ion binding]; other site 337191009425 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 337191009426 Domain of unknown function DUF21; Region: DUF21; pfam01595 337191009427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 337191009428 Transporter associated domain; Region: CorC_HlyC; smart01091 337191009429 metal-binding heat shock protein; Provisional; Region: PRK00016 337191009430 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 337191009431 PhoH-like protein; Region: PhoH; pfam02562 337191009432 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191009433 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191009434 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 337191009435 chaperone protein DnaJ; Provisional; Region: PRK14278 337191009436 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 337191009437 HSP70 interaction site [polypeptide binding]; other site 337191009438 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 337191009439 Zn binding sites [ion binding]; other site 337191009440 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 337191009441 dimer interface [polypeptide binding]; other site 337191009442 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 337191009443 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 337191009444 HrcA protein C terminal domain; Region: HrcA; pfam01628 337191009445 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 337191009446 coproporphyrinogen III oxidase; Validated; Region: PRK05628 337191009447 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191009448 FeS/SAM binding site; other site 337191009449 HemN C-terminal domain; Region: HemN_C; pfam06969 337191009450 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 337191009451 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 337191009452 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 337191009453 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 337191009454 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 337191009455 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 337191009456 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 337191009457 Active Sites [active] 337191009458 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 337191009459 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 337191009460 Active Sites [active] 337191009461 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 337191009462 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 337191009463 CysD dimerization site [polypeptide binding]; other site 337191009464 G1 box; other site 337191009465 putative GEF interaction site [polypeptide binding]; other site 337191009466 GTP/Mg2+ binding site [chemical binding]; other site 337191009467 Switch I region; other site 337191009468 G2 box; other site 337191009469 G3 box; other site 337191009470 Switch II region; other site 337191009471 G4 box; other site 337191009472 G5 box; other site 337191009473 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 337191009474 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 337191009475 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 337191009476 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 337191009477 putative active site [active] 337191009478 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 337191009479 active site 337191009480 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 337191009481 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 337191009482 dimer interface [polypeptide binding]; other site 337191009483 PYR/PP interface [polypeptide binding]; other site 337191009484 TPP binding site [chemical binding]; other site 337191009485 substrate binding site [chemical binding]; other site 337191009486 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 337191009487 TPP-binding site; other site 337191009488 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 337191009489 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 337191009490 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 337191009491 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 337191009492 substrate binding site [chemical binding]; other site 337191009493 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 337191009494 substrate binding site [chemical binding]; other site 337191009495 ligand binding site [chemical binding]; other site 337191009496 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191009497 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191009498 putative DNA binding site [nucleotide binding]; other site 337191009499 putative Zn2+ binding site [ion binding]; other site 337191009500 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 337191009501 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 337191009502 transmembrane helices; other site 337191009503 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191009504 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 337191009505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191009506 substrate binding site [chemical binding]; other site 337191009507 oxyanion hole (OAH) forming residues; other site 337191009508 trimer interface [polypeptide binding]; other site 337191009509 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191009510 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 337191009511 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191009512 Bacterial transcriptional regulator; Region: IclR; pfam01614 337191009513 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191009514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191009515 putative DNA binding site [nucleotide binding]; other site 337191009516 putative Zn2+ binding site [ion binding]; other site 337191009517 AsnC family; Region: AsnC_trans_reg; pfam01037 337191009518 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 337191009519 GntP family permease; Region: GntP_permease; pfam02447 337191009520 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 337191009521 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 337191009522 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191009523 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191009524 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 337191009525 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191009526 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191009527 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 337191009528 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 337191009529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191009530 active site 337191009531 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 337191009532 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191009533 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191009534 active site 337191009535 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191009536 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191009537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191009538 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191009539 active site 337191009540 CoA binding site [chemical binding]; other site 337191009541 AMP binding site [chemical binding]; other site 337191009542 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 337191009543 Phosphotransferase enzyme family; Region: APH; pfam01636 337191009544 putative active site [active] 337191009545 putative substrate binding site [chemical binding]; other site 337191009546 ATP binding site [chemical binding]; other site 337191009547 acyl-CoA synthetase; Provisional; Region: PRK13391 337191009548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191009549 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 337191009550 acyl-activating enzyme (AAE) consensus motif; other site 337191009551 putative AMP binding site [chemical binding]; other site 337191009552 putative active site [active] 337191009553 putative CoA binding site [chemical binding]; other site 337191009554 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 337191009555 enoyl-CoA hydratase; Provisional; Region: PRK08260 337191009556 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191009557 substrate binding site [chemical binding]; other site 337191009558 oxyanion hole (OAH) forming residues; other site 337191009559 trimer interface [polypeptide binding]; other site 337191009560 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 337191009561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191009562 NAD(P) binding site [chemical binding]; other site 337191009563 active site 337191009564 lipid-transfer protein; Provisional; Region: PRK08256 337191009565 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 337191009566 active site 337191009567 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 337191009568 active site 337191009569 catalytic site [active] 337191009570 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191009571 active site 2 [active] 337191009572 active site 1 [active] 337191009573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191009574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191009575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191009576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191009577 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191009578 classical (c) SDRs; Region: SDR_c; cd05233 337191009579 NAD(P) binding site [chemical binding]; other site 337191009580 active site 337191009581 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 337191009582 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 337191009583 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 337191009584 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 337191009585 active site 337191009586 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 337191009587 active site 337191009588 Fe binding site [ion binding]; other site 337191009589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191009590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191009591 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 337191009592 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 337191009593 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 337191009594 shikimate binding site; other site 337191009595 NAD(P) binding site [chemical binding]; other site 337191009596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191009597 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191009598 putative substrate translocation pore; other site 337191009599 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191009600 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 337191009601 Bacterial transcriptional regulator; Region: IclR; pfam01614 337191009602 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 337191009603 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 337191009604 active site 337191009605 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 337191009606 heterodimer interface [polypeptide binding]; other site 337191009607 active site 337191009608 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 337191009609 tetramer interface [polypeptide binding]; other site 337191009610 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 337191009611 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 337191009612 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 337191009613 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 337191009614 active site 337191009615 Zn binding site [ion binding]; other site 337191009616 GTP-binding protein LepA; Provisional; Region: PRK05433 337191009617 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 337191009618 putative GEF interaction site [polypeptide binding]; other site 337191009619 Switch I region; other site 337191009620 G2 box; other site 337191009621 G3 box; other site 337191009622 Switch II region; other site 337191009623 GTP/Mg2+ binding site [chemical binding]; other site 337191009624 G4 box; other site 337191009625 G5 box; other site 337191009626 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 337191009627 Elongation Factor G, domain II; Region: EFG_II; pfam14492 337191009628 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 337191009629 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 337191009630 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191009631 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191009632 PemK-like protein; Region: PemK; pfam02452 337191009633 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 337191009634 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 337191009635 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 337191009636 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl19824 337191009637 Uncharacterized conserved protein [Function unknown]; Region: COG2308 337191009638 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 337191009639 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 337191009640 hypothetical protein; Reviewed; Region: PRK07914 337191009641 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 337191009642 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 337191009643 Competence protein; Region: Competence; pfam03772 337191009644 SLBB domain; Region: SLBB; pfam10531 337191009645 comEA protein; Region: comE; TIGR01259 337191009646 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 337191009647 EDD domain protein, DegV family; Region: DegV; TIGR00762 337191009648 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 337191009649 active site 337191009650 catalytic triad [active] 337191009651 oxyanion hole [active] 337191009652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 337191009653 catalytic core [active] 337191009654 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 337191009655 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 337191009656 active site 337191009657 (T/H)XGH motif; other site 337191009658 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 337191009659 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 337191009660 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 337191009661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191009662 Walker A motif; other site 337191009663 ATP binding site [chemical binding]; other site 337191009664 Walker B motif; other site 337191009665 arginine finger; other site 337191009666 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 337191009667 putative catalytic cysteine [active] 337191009668 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 337191009669 putative homodimer interface [polypeptide binding]; other site 337191009670 putative homotetramer interface [polypeptide binding]; other site 337191009671 putative allosteric switch controlling residues; other site 337191009672 putative metal binding site [ion binding]; other site 337191009673 putative homodimer-homodimer interface [polypeptide binding]; other site 337191009674 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 337191009675 MMPL family; Region: MMPL; cl14618 337191009676 MMPL family; Region: MMPL; cl14618 337191009677 Domain of unknown function DUF302; Region: DUF302; cl01364 337191009678 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 337191009679 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 337191009680 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 337191009681 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 337191009682 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 337191009683 generic binding surface II; other site 337191009684 ssDNA binding site; other site 337191009685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191009686 ATP binding site [chemical binding]; other site 337191009687 putative Mg++ binding site [ion binding]; other site 337191009688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191009689 nucleotide binding region [chemical binding]; other site 337191009690 ATP-binding site [chemical binding]; other site 337191009691 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 337191009692 DAK2 domain; Region: Dak2; pfam02734 337191009693 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 337191009694 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 337191009695 enoyl-CoA hydratase; Provisional; Region: PRK06688 337191009696 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191009697 substrate binding site [chemical binding]; other site 337191009698 oxyanion hole (OAH) forming residues; other site 337191009699 trimer interface [polypeptide binding]; other site 337191009700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191009701 Transposase; Region: DEDD_Tnp_IS110; pfam01548 337191009702 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191009703 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 337191009704 ligand binding site [chemical binding]; other site 337191009705 active site 337191009706 UGI interface [polypeptide binding]; other site 337191009707 catalytic site [active] 337191009708 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 337191009709 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 337191009710 trimer interface [polypeptide binding]; other site 337191009711 putative metal binding site [ion binding]; other site 337191009712 thiamine monophosphate kinase; Provisional; Region: PRK05731 337191009713 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 337191009714 ATP binding site [chemical binding]; other site 337191009715 dimerization interface [polypeptide binding]; other site 337191009716 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191009717 AsnC family; Region: AsnC_trans_reg; pfam01037 337191009718 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 337191009719 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 337191009720 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 337191009721 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 337191009722 Guanylyl transferase CofC like; Region: CofC; cl17472 337191009723 polyphosphate kinase; Provisional; Region: PRK05443 337191009724 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 337191009725 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 337191009726 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 337191009727 putative domain interface [polypeptide binding]; other site 337191009728 putative active site [active] 337191009729 catalytic site [active] 337191009730 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 337191009731 putative active site [active] 337191009732 catalytic site [active] 337191009733 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 337191009734 active site 337191009735 Ap6A binding site [chemical binding]; other site 337191009736 nudix motif; other site 337191009737 metal binding site [ion binding]; metal-binding site 337191009738 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 337191009739 catalytic core [active] 337191009740 histone-like DNA-binding protein HU; Region: HU; cd13831 337191009741 dimer interface [polypeptide binding]; other site 337191009742 DNA binding site [nucleotide binding] 337191009743 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 337191009744 substrate binding site [chemical binding]; other site 337191009745 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 337191009746 substrate binding site [chemical binding]; other site 337191009747 ligand binding site [chemical binding]; other site 337191009748 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191009749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191009750 putative DNA binding site [nucleotide binding]; other site 337191009751 putative Zn2+ binding site [ion binding]; other site 337191009752 Bacterial transcriptional regulator; Region: IclR; pfam01614 337191009753 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 337191009754 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 337191009755 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 337191009756 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 337191009757 active site 337191009758 HIGH motif; other site 337191009759 KMSKS motif; other site 337191009760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191009761 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 337191009762 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 337191009763 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 337191009764 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 337191009765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191009766 putative substrate translocation pore; other site 337191009767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191009768 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 337191009769 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 337191009770 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 337191009771 ligand binding site [chemical binding]; other site 337191009772 NAD binding site [chemical binding]; other site 337191009773 dimerization interface [polypeptide binding]; other site 337191009774 catalytic site [active] 337191009775 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 337191009776 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 337191009777 Homeodomain-like domain; Region: HTH_23; cl17451 337191009778 Winged helix-turn helix; Region: HTH_29; pfam13551 337191009779 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 337191009780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 337191009781 Integrase core domain; Region: rve; pfam00665 337191009782 Integrase core domain; Region: rve_3; pfam13683 337191009783 ketol-acid reductoisomerase; Provisional; Region: PRK05479 337191009784 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 337191009785 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 337191009786 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 337191009787 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 337191009788 putative valine binding site [chemical binding]; other site 337191009789 dimer interface [polypeptide binding]; other site 337191009790 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 337191009791 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 337191009792 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 337191009793 PYR/PP interface [polypeptide binding]; other site 337191009794 dimer interface [polypeptide binding]; other site 337191009795 TPP binding site [chemical binding]; other site 337191009796 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 337191009797 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 337191009798 TPP-binding site [chemical binding]; other site 337191009799 dimer interface [polypeptide binding]; other site 337191009800 Bacterial PH domain; Region: bPH_6; pfam10756 337191009801 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 337191009802 MgtE intracellular N domain; Region: MgtE_N; smart00924 337191009803 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 337191009804 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 337191009805 Divalent cation transporter; Region: MgtE; pfam01769 337191009806 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 337191009807 Predicted membrane protein [Function unknown]; Region: COG2259 337191009808 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 337191009809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191009810 Transposase; Region: DEDD_Tnp_IS110; pfam01548 337191009811 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191009812 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 337191009813 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 337191009814 GatB domain; Region: GatB_Yqey; smart00845 337191009815 PspC domain; Region: PspC; pfam04024 337191009816 phosphofructokinase; Region: PFK_mixed; TIGR02483 337191009817 active site 337191009818 ADP/pyrophosphate binding site [chemical binding]; other site 337191009819 dimerization interface [polypeptide binding]; other site 337191009820 allosteric effector site; other site 337191009821 fructose-1,6-bisphosphate binding site; other site 337191009822 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191009823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191009824 active site 337191009825 phosphorylation site [posttranslational modification] 337191009826 intermolecular recognition site; other site 337191009827 dimerization interface [polypeptide binding]; other site 337191009828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191009829 DNA binding residues [nucleotide binding] 337191009830 dimerization interface [polypeptide binding]; other site 337191009831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 337191009832 Histidine kinase; Region: HisKA_3; pfam07730 337191009833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191009834 ATP binding site [chemical binding]; other site 337191009835 Mg2+ binding site [ion binding]; other site 337191009836 G-X-G motif; other site 337191009837 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 337191009838 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 337191009839 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 337191009840 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 337191009841 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 337191009842 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 337191009843 putative ADP-ribose binding site [chemical binding]; other site 337191009844 putative active site [active] 337191009845 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 337191009846 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 337191009847 nucleotide binding pocket [chemical binding]; other site 337191009848 K-X-D-G motif; other site 337191009849 catalytic site [active] 337191009850 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 337191009851 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 337191009852 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 337191009853 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 337191009854 Dimer interface [polypeptide binding]; other site 337191009855 BRCT sequence motif; other site 337191009856 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191009857 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191009858 active site 337191009859 YjbR; Region: YjbR; pfam04237 337191009860 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 337191009861 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 337191009862 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 337191009863 Ligand Binding Site [chemical binding]; other site 337191009864 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 337191009865 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191009866 catalytic residue [active] 337191009867 GXWXG protein; Region: GXWXG; pfam14231 337191009868 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 337191009869 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 337191009870 putative acyl-acceptor binding pocket; other site 337191009871 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 337191009872 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 337191009873 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 337191009874 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 337191009875 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 337191009876 Ligand binding site [chemical binding]; other site 337191009877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191009878 Methyltransferase domain; Region: Methyltransf_31; pfam13847 337191009879 S-adenosylmethionine binding site [chemical binding]; other site 337191009880 Uncharacterized conserved protein [Function unknown]; Region: COG1543 337191009881 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 337191009882 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 337191009883 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191009884 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 337191009885 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 337191009886 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 337191009887 trimer interface [polypeptide binding]; other site 337191009888 active site 337191009889 substrate binding site [chemical binding]; other site 337191009890 CoA binding site [chemical binding]; other site 337191009891 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 337191009892 PQQ-like domain; Region: PQQ_2; pfam13360 337191009893 active site 337191009894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191009895 AAA domain; Region: AAA_17; pfam13207 337191009896 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 337191009897 CHAT domain; Region: CHAT; cl19248 337191009898 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 337191009899 active site 337191009900 Int/Topo IB signature motif; other site 337191009901 Methyltransferase domain; Region: Methyltransf_31; pfam13847 337191009902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191009903 S-adenosylmethionine binding site [chemical binding]; other site 337191009904 enoyl-CoA hydratase; Provisional; Region: PRK07657 337191009905 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191009906 substrate binding site [chemical binding]; other site 337191009907 oxyanion hole (OAH) forming residues; other site 337191009908 trimer interface [polypeptide binding]; other site 337191009909 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 337191009910 nucleotide binding site [chemical binding]; other site 337191009911 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191009912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 337191009913 putative DNA binding site [nucleotide binding]; other site 337191009914 putative Zn2+ binding site [ion binding]; other site 337191009915 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 337191009916 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 337191009917 NUDIX domain; Region: NUDIX; pfam00293 337191009918 nudix motif; other site 337191009919 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 337191009920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191009921 Walker A/P-loop; other site 337191009922 ATP binding site [chemical binding]; other site 337191009923 Q-loop/lid; other site 337191009924 ABC transporter signature motif; other site 337191009925 Walker B; other site 337191009926 D-loop; other site 337191009927 H-loop/switch region; other site 337191009928 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191009929 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 337191009930 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 337191009931 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; cl19212 337191009932 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 337191009933 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 337191009934 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 337191009935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191009936 motif II; other site 337191009937 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 337191009938 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 337191009939 D-pathway; other site 337191009940 Putative ubiquinol binding site [chemical binding]; other site 337191009941 Low-spin heme (heme b) binding site [chemical binding]; other site 337191009942 Putative water exit pathway; other site 337191009943 Binuclear center (heme o3/CuB) [ion binding]; other site 337191009944 K-pathway; other site 337191009945 Putative proton exit pathway; other site 337191009946 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 337191009947 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 337191009948 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 337191009949 intersubunit interface [polypeptide binding]; other site 337191009950 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 337191009951 active site clefts [active] 337191009952 zinc binding site [ion binding]; other site 337191009953 dimer interface [polypeptide binding]; other site 337191009954 SNF2 Helicase protein; Region: DUF3670; pfam12419 337191009955 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 337191009956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 337191009957 ATP binding site [chemical binding]; other site 337191009958 putative Mg++ binding site [ion binding]; other site 337191009959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191009960 nucleotide binding region [chemical binding]; other site 337191009961 ATP-binding site [chemical binding]; other site 337191009962 SWIM zinc finger; Region: SWIM; cl19527 337191009963 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 337191009964 dimer interface [polypeptide binding]; other site 337191009965 putative radical transfer pathway; other site 337191009966 diiron center [ion binding]; other site 337191009967 tyrosyl radical; other site 337191009968 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 337191009969 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 337191009970 Class I ribonucleotide reductase; Region: RNR_I; cd01679 337191009971 active site 337191009972 dimer interface [polypeptide binding]; other site 337191009973 catalytic residues [active] 337191009974 effector binding site; other site 337191009975 R2 peptide binding site; other site 337191009976 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 337191009977 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 337191009978 catalytic residues [active] 337191009979 Predicted flavoprotein [General function prediction only]; Region: COG0431 337191009980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191009981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191009982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191009983 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 337191009984 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 337191009985 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 337191009986 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 337191009987 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 337191009988 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 337191009989 Transcription factor WhiB; Region: Whib; pfam02467 337191009990 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 337191009991 dimer interface [polypeptide binding]; other site 337191009992 substrate binding site [chemical binding]; other site 337191009993 phosphate binding site [ion binding]; other site 337191009994 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 337191009995 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 337191009996 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 337191009997 FMN binding site [chemical binding]; other site 337191009998 dimer interface [polypeptide binding]; other site 337191009999 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 337191010000 nudix motif; other site 337191010001 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 337191010002 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 337191010003 oligomer interface; other site 337191010004 ligand binding site; other site 337191010005 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 337191010006 dimer interface [polypeptide binding]; other site 337191010007 N-terminal domain interface [polypeptide binding]; other site 337191010008 sulfate 1 binding site; other site 337191010009 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 337191010010 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 337191010011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 337191010012 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 337191010013 DivIVA domain; Region: DivI1A_domain; TIGR03544 337191010014 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 337191010015 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 337191010016 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 337191010017 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 337191010018 substrate binding pocket [chemical binding]; other site 337191010019 dimer interface [polypeptide binding]; other site 337191010020 inhibitor binding site; inhibition site 337191010021 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 337191010022 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 337191010023 acyl-activating enzyme (AAE) consensus motif; other site 337191010024 putative AMP binding site [chemical binding]; other site 337191010025 putative active site [active] 337191010026 putative CoA binding site [chemical binding]; other site 337191010027 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 337191010028 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 337191010029 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 337191010030 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 337191010031 metal binding site [ion binding]; metal-binding site 337191010032 putative dimer interface [polypeptide binding]; other site 337191010033 Electron transfer DM13; Region: DM13; pfam10517 337191010034 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 337191010035 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 337191010036 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 337191010037 putative trimer interface [polypeptide binding]; other site 337191010038 putative CoA binding site [chemical binding]; other site 337191010039 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 337191010040 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 337191010041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191010042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191010043 homodimer interface [polypeptide binding]; other site 337191010044 catalytic residue [active] 337191010045 Ferredoxin [Energy production and conversion]; Region: COG1146 337191010046 4Fe-4S binding domain; Region: Fer4; pfam00037 337191010047 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 337191010048 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 337191010049 active site residue [active] 337191010050 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Region: F420_cofG; TIGR03550 337191010051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191010052 FeS/SAM binding site; other site 337191010053 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191010054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191010055 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 337191010056 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 337191010057 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191010058 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 337191010059 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 337191010060 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 337191010061 G1 box; other site 337191010062 putative GEF interaction site [polypeptide binding]; other site 337191010063 GTP/Mg2+ binding site [chemical binding]; other site 337191010064 Switch I region; other site 337191010065 G2 box; other site 337191010066 G3 box; other site 337191010067 Switch II region; other site 337191010068 G4 box; other site 337191010069 G5 box; other site 337191010070 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 337191010071 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 337191010072 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 337191010073 EamA-like transporter family; Region: EamA; pfam00892 337191010074 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 337191010075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191010076 Walker A/P-loop; other site 337191010077 ATP binding site [chemical binding]; other site 337191010078 Q-loop/lid; other site 337191010079 ABC transporter signature motif; other site 337191010080 Walker B; other site 337191010081 D-loop; other site 337191010082 H-loop/switch region; other site 337191010083 TOBE domain; Region: TOBE_2; pfam08402 337191010084 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 337191010085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191010086 dimer interface [polypeptide binding]; other site 337191010087 conserved gate region; other site 337191010088 putative PBP binding loops; other site 337191010089 ABC-ATPase subunit interface; other site 337191010090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191010091 dimer interface [polypeptide binding]; other site 337191010092 conserved gate region; other site 337191010093 putative PBP binding loops; other site 337191010094 ABC-ATPase subunit interface; other site 337191010095 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 337191010096 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 337191010097 Secretory lipase; Region: LIP; pfam03583 337191010098 YhhN-like protein; Region: YhhN; pfam07947 337191010099 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 337191010100 catalytic residues [active] 337191010101 catalytic nucleophile [active] 337191010102 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 337191010103 Recombinase; Region: Recombinase; pfam07508 337191010104 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 337191010105 Phage terminase, small subunit; Region: Terminase_4; cl01525 337191010106 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191010107 active site 337191010108 Phage capsid family; Region: Phage_capsid; pfam05065 337191010109 Helix-turn-helix domain; Region: HTH_36; pfam13730 337191010110 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 337191010111 minor groove reading motif; other site 337191010112 helix-hairpin-helix signature motif; other site 337191010113 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191010114 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191010115 active site 337191010116 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191010117 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 337191010118 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 337191010119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191010120 active site 337191010121 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 337191010122 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 337191010123 enoyl-CoA hydratase; Provisional; Region: PRK06494 337191010124 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191010125 substrate binding site [chemical binding]; other site 337191010126 oxyanion hole (OAH) forming residues; other site 337191010127 trimer interface [polypeptide binding]; other site 337191010128 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 337191010129 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 337191010130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191010131 active site 337191010132 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 337191010133 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 337191010134 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191010135 active site 337191010136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191010137 enoyl-CoA hydratase; Validated; Region: PRK08139 337191010138 substrate binding site [chemical binding]; other site 337191010139 oxyanion hole (OAH) forming residues; other site 337191010140 trimer interface [polypeptide binding]; other site 337191010141 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191010142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191010143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191010144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191010145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191010146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191010147 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191010148 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 337191010149 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 337191010150 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 337191010151 Walker A/P-loop; other site 337191010152 ATP binding site [chemical binding]; other site 337191010153 Q-loop/lid; other site 337191010154 ABC transporter signature motif; other site 337191010155 Walker B; other site 337191010156 D-loop; other site 337191010157 H-loop/switch region; other site 337191010158 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 337191010159 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 337191010160 Walker A/P-loop; other site 337191010161 ATP binding site [chemical binding]; other site 337191010162 Q-loop/lid; other site 337191010163 ABC transporter signature motif; other site 337191010164 Walker B; other site 337191010165 D-loop; other site 337191010166 H-loop/switch region; other site 337191010167 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 337191010168 TM-ABC transporter signature motif; other site 337191010169 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 337191010170 TM-ABC transporter signature motif; other site 337191010171 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 337191010172 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 337191010173 putative ligand binding site [chemical binding]; other site 337191010174 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 337191010175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191010176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191010177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191010178 putative substrate translocation pore; other site 337191010179 Uncharacterized conserved protein [Function unknown]; Region: COG2128 337191010180 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 337191010181 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 337191010182 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 337191010183 cyanate hydratase; Validated; Region: PRK02866 337191010184 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 337191010185 oligomer interface [polypeptide binding]; other site 337191010186 active site 337191010187 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 337191010188 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 337191010189 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 337191010190 nucleoside/Zn binding site; other site 337191010191 dimer interface [polypeptide binding]; other site 337191010192 catalytic motif [active] 337191010193 oxidase reductase; Provisional; Region: PTZ00273 337191010194 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 337191010195 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 337191010196 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 337191010197 active site 337191010198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191010199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191010200 Coenzyme A binding pocket [chemical binding]; other site 337191010201 Trypsin; Region: Trypsin; pfam00089 337191010202 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 337191010203 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 337191010204 protein binding site [polypeptide binding]; other site 337191010205 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 337191010206 putative dimer interface [polypeptide binding]; other site 337191010207 methionine sulfoxide reductase A; Provisional; Region: PRK05528 337191010208 GTP-binding protein YchF; Reviewed; Region: PRK09601 337191010209 YchF GTPase; Region: YchF; cd01900 337191010210 G1 box; other site 337191010211 GTP/Mg2+ binding site [chemical binding]; other site 337191010212 Switch I region; other site 337191010213 G2 box; other site 337191010214 Switch II region; other site 337191010215 G3 box; other site 337191010216 G4 box; other site 337191010217 G5 box; other site 337191010218 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 337191010219 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 337191010220 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 337191010221 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 337191010222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191010223 AlkA N-terminal domain; Region: AlkA_N; pfam06029 337191010224 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 337191010225 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 337191010226 minor groove reading motif; other site 337191010227 helix-hairpin-helix signature motif; other site 337191010228 substrate binding pocket [chemical binding]; other site 337191010229 active site 337191010230 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 337191010231 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 337191010232 active site 337191010233 DNA binding site [nucleotide binding] 337191010234 RmuC family; Region: RmuC; pfam02646 337191010235 ribonuclease III; Reviewed; Region: PRK12372 337191010236 nucleosidase; Provisional; Region: PRK05634 337191010237 Fructosamine kinase; Region: Fructosamin_kin; cl17579 337191010238 Phosphotransferase enzyme family; Region: APH; pfam01636 337191010239 short chain dehydrogenase; Provisional; Region: PRK05650 337191010240 classical (c) SDRs; Region: SDR_c; cd05233 337191010241 NAD(P) binding site [chemical binding]; other site 337191010242 active site 337191010243 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 337191010244 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 337191010245 active site 337191010246 metal binding site [ion binding]; metal-binding site 337191010247 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 337191010248 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 337191010249 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 337191010250 hypothetical protein; Validated; Region: PRK01415 337191010251 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 337191010252 active site residue [active] 337191010253 Lsr2; Region: Lsr2; pfam11774 337191010254 hypothetical protein; Provisional; Region: PRK07945 337191010255 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 337191010256 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 337191010257 active site 337191010258 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 337191010259 active site 337191010260 dimer interface [polypeptide binding]; other site 337191010261 non-prolyl cis peptide bond; other site 337191010262 insertion regions; other site 337191010263 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 337191010264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 337191010265 substrate binding pocket [chemical binding]; other site 337191010266 membrane-bound complex binding site; other site 337191010267 hinge residues; other site 337191010268 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 337191010269 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 337191010270 Walker A/P-loop; other site 337191010271 ATP binding site [chemical binding]; other site 337191010272 Q-loop/lid; other site 337191010273 ABC transporter signature motif; other site 337191010274 Walker B; other site 337191010275 D-loop; other site 337191010276 H-loop/switch region; other site 337191010277 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 337191010278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191010279 dimer interface [polypeptide binding]; other site 337191010280 conserved gate region; other site 337191010281 putative PBP binding loops; other site 337191010282 ABC-ATPase subunit interface; other site 337191010283 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 337191010284 Beta-lactamase; Region: Beta-lactamase; pfam00144 337191010285 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 337191010286 putative active site [active] 337191010287 metal binding site [ion binding]; metal-binding site 337191010288 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 337191010289 putative hydrophobic ligand binding site [chemical binding]; other site 337191010290 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191010291 dimerization interface [polypeptide binding]; other site 337191010292 putative DNA binding site [nucleotide binding]; other site 337191010293 putative Zn2+ binding site [ion binding]; other site 337191010294 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191010295 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191010296 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 337191010297 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191010298 ABC transporter; Region: ABC_tran_2; pfam12848 337191010299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 337191010300 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 337191010301 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 337191010302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191010303 Walker A motif; other site 337191010304 ATP binding site [chemical binding]; other site 337191010305 Walker B motif; other site 337191010306 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 337191010307 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 337191010308 metal ion-dependent adhesion site (MIDAS); other site 337191010309 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191010310 active site 337191010311 YppG-like protein; Region: YppG; pfam14179 337191010312 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 337191010313 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191010314 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191010315 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 337191010316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191010317 dimerization interface [polypeptide binding]; other site 337191010318 putative DNA binding site [nucleotide binding]; other site 337191010319 putative Zn2+ binding site [ion binding]; other site 337191010320 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191010321 hydrophobic ligand binding site; other site 337191010322 YCII-related domain; Region: YCII; cl00999 337191010323 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 337191010324 Thioredoxin; Region: Thioredoxin_4; cl17273 337191010325 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 337191010326 catalytic residues [active] 337191010327 phosphoglucomutase; Validated; Region: PRK07564 337191010328 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 337191010329 active site 337191010330 substrate binding site [chemical binding]; other site 337191010331 metal binding site [ion binding]; metal-binding site 337191010332 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191010333 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 337191010334 nucleophilic elbow; other site 337191010335 catalytic triad; other site 337191010336 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 337191010337 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 337191010338 acyl-activating enzyme (AAE) consensus motif; other site 337191010339 putative AMP binding site [chemical binding]; other site 337191010340 putative active site [active] 337191010341 putative CoA binding site [chemical binding]; other site 337191010342 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191010343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 337191010344 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 337191010345 Walker A/P-loop; other site 337191010346 ATP binding site [chemical binding]; other site 337191010347 Q-loop/lid; other site 337191010348 ABC transporter signature motif; other site 337191010349 Walker B; other site 337191010350 D-loop; other site 337191010351 H-loop/switch region; other site 337191010352 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 337191010353 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 337191010354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 337191010355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191010356 S-adenosylmethionine binding site [chemical binding]; other site 337191010357 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 337191010358 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 337191010359 metal binding site [ion binding]; metal-binding site 337191010360 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 337191010361 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 337191010362 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 337191010363 ABC-ATPase subunit interface; other site 337191010364 dimer interface [polypeptide binding]; other site 337191010365 putative PBP binding regions; other site 337191010366 TIR domain; Region: TIR_2; cl17458 337191010367 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 337191010368 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 337191010369 DNA binding site [nucleotide binding] 337191010370 active site 337191010371 Int/Topo IB signature motif; other site 337191010372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191010373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191010374 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 337191010375 SmpB-tmRNA interface; other site 337191010376 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 337191010377 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 337191010378 FtsX-like permease family; Region: FtsX; pfam02687 337191010379 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 337191010380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191010381 Walker A/P-loop; other site 337191010382 ATP binding site [chemical binding]; other site 337191010383 Q-loop/lid; other site 337191010384 ABC transporter signature motif; other site 337191010385 Walker B; other site 337191010386 D-loop; other site 337191010387 H-loop/switch region; other site 337191010388 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 337191010389 Mechanosensitive ion channel; Region: MS_channel; pfam00924 337191010390 peptide chain release factor 2; Validated; Region: prfB; PRK00578 337191010391 This domain is found in peptide chain release factors; Region: PCRF; smart00937 337191010392 RF-1 domain; Region: RF-1; pfam00472 337191010393 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 337191010394 active site 337191010395 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 337191010396 phosphate binding site [ion binding]; other site 337191010397 Domain of unknown function (DUF385); Region: DUF385; cl04387 337191010398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191010399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191010400 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 337191010401 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 337191010402 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191010403 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191010404 active site 337191010405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191010406 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191010407 active site 337191010408 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 337191010409 CrcB-like protein; Region: CRCB; pfam02537 337191010410 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 337191010411 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 337191010412 acyl-activating enzyme (AAE) consensus motif; other site 337191010413 putative AMP binding site [chemical binding]; other site 337191010414 putative active site [active] 337191010415 putative CoA binding site [chemical binding]; other site 337191010416 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 337191010417 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 337191010418 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191010419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 337191010420 Histidine kinase; Region: HisKA_3; pfam07730 337191010421 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191010422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191010423 active site 337191010424 phosphorylation site [posttranslational modification] 337191010425 intermolecular recognition site; other site 337191010426 dimerization interface [polypeptide binding]; other site 337191010427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191010428 DNA binding residues [nucleotide binding] 337191010429 dimerization interface [polypeptide binding]; other site 337191010430 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 337191010431 DNA binding site [nucleotide binding] 337191010432 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191010433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191010434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191010435 hypothetical protein; Validated; Region: PRK00068 337191010436 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 337191010437 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 337191010438 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 337191010439 protein binding site [polypeptide binding]; other site 337191010440 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 337191010441 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 337191010442 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 337191010443 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 337191010444 active site 337191010445 ATP binding site [chemical binding]; other site 337191010446 Transcription factor WhiB; Region: Whib; pfam02467 337191010447 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 337191010448 Part of AAA domain; Region: AAA_19; pfam13245 337191010449 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 337191010450 HRDC domain; Region: HRDC; pfam00570 337191010451 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 337191010452 catalytic residues [active] 337191010453 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 337191010454 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 337191010455 putative NADH binding site [chemical binding]; other site 337191010456 putative active site [active] 337191010457 nudix motif; other site 337191010458 putative metal binding site [ion binding]; other site 337191010459 Ion channel; Region: Ion_trans_2; pfam07885 337191010460 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 337191010461 TrkA-N domain; Region: TrkA_N; pfam02254 337191010462 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 337191010463 Part of AAA domain; Region: AAA_19; pfam13245 337191010464 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 337191010465 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 337191010466 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 337191010467 Part of AAA domain; Region: AAA_19; pfam13245 337191010468 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 337191010469 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191010470 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191010471 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 337191010472 catalytic site [active] 337191010473 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 337191010474 active site 337191010475 DNA binding site [nucleotide binding] 337191010476 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 337191010477 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 337191010478 putative active site [active] 337191010479 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 337191010480 putative active site [active] 337191010481 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 337191010482 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 337191010483 active site 337191010484 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 337191010485 DNA binding site [nucleotide binding] 337191010486 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 337191010487 nitrite reductase subunit NirD; Provisional; Region: PRK14989 337191010488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191010489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191010490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191010491 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 337191010492 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 337191010493 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 337191010494 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 337191010495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191010496 putative substrate translocation pore; other site 337191010497 TIGR02569 family protein; Region: TIGR02569_actnb 337191010498 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 337191010499 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 337191010500 ATP binding site [chemical binding]; other site 337191010501 substrate interface [chemical binding]; other site 337191010502 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 337191010503 active site residue [active] 337191010504 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 337191010505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191010506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191010507 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 337191010508 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 337191010509 dinuclear metal binding motif [ion binding]; other site 337191010510 helicase 45; Provisional; Region: PTZ00424 337191010511 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 337191010512 ATP binding site [chemical binding]; other site 337191010513 Mg++ binding site [ion binding]; other site 337191010514 motif III; other site 337191010515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191010516 nucleotide binding region [chemical binding]; other site 337191010517 ATP-binding site [chemical binding]; other site 337191010518 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 337191010519 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 337191010520 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 337191010521 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191010522 P-loop; other site 337191010523 Magnesium ion binding site [ion binding]; other site 337191010524 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 337191010525 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 337191010526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191010527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191010528 Transcription factor WhiB; Region: Whib; pfam02467 337191010529 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 337191010530 PAS domain S-box; Region: sensory_box; TIGR00229 337191010531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 337191010532 Histidine kinase; Region: HisKA_2; pfam07568 337191010533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191010534 ATP binding site [chemical binding]; other site 337191010535 Mg2+ binding site [ion binding]; other site 337191010536 G-X-G motif; other site 337191010537 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 337191010538 carboxyltransferase (CT) interaction site; other site 337191010539 biotinylation site [posttranslational modification]; other site 337191010540 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 337191010541 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 337191010542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191010543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191010544 DNA binding residues [nucleotide binding] 337191010545 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 337191010546 putative deacylase active site [active] 337191010547 Uncharacterized conserved protein [Function unknown]; Region: COG2135 337191010548 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191010549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191010550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191010551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191010552 putative substrate translocation pore; other site 337191010553 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 337191010554 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 337191010555 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 337191010556 FAD binding domain; Region: FAD_binding_4; pfam01565 337191010557 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 337191010558 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 337191010559 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 337191010560 NAD(P) binding site [chemical binding]; other site 337191010561 putative active site [active] 337191010562 Predicted membrane protein [Function unknown]; Region: COG2261 337191010563 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 337191010564 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 337191010565 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 337191010566 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191010567 P-loop; other site 337191010568 Magnesium ion binding site [ion binding]; other site 337191010569 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 337191010570 hypothetical protein; Provisional; Region: PRK12361 337191010571 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 337191010572 nudix motif; other site 337191010573 aminotransferase; Validated; Region: PRK07337 337191010574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191010575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191010576 homodimer interface [polypeptide binding]; other site 337191010577 catalytic residue [active] 337191010578 Beta-lactamase; Region: Beta-lactamase; pfam00144 337191010579 FAD binding domain; Region: FAD_binding_4; cl19922 337191010580 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 337191010581 GAF domain; Region: GAF; pfam01590 337191010582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191010583 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191010584 DNA binding residues [nucleotide binding] 337191010585 dimerization interface [polypeptide binding]; other site 337191010586 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 337191010587 dimerization interface [polypeptide binding]; other site 337191010588 putative path to active site cavity [active] 337191010589 diiron center [ion binding]; other site 337191010590 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 337191010591 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191010592 catalytic loop [active] 337191010593 iron binding site [ion binding]; other site 337191010594 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 337191010595 FAD binding pocket [chemical binding]; other site 337191010596 conserved FAD binding motif [chemical binding]; other site 337191010597 phosphate binding motif [ion binding]; other site 337191010598 beta-alpha-beta structure motif; other site 337191010599 NAD binding pocket [chemical binding]; other site 337191010600 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 337191010601 dimerization interface [polypeptide binding]; other site 337191010602 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 337191010603 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 337191010604 active site 337191010605 Domain of unknown function DUF59; Region: DUF59; pfam01883 337191010606 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 337191010607 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 337191010608 NAD binding site [chemical binding]; other site 337191010609 substrate binding site [chemical binding]; other site 337191010610 catalytic Zn binding site [ion binding]; other site 337191010611 structural Zn binding site [ion binding]; other site 337191010612 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 337191010613 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 337191010614 ring oligomerisation interface [polypeptide binding]; other site 337191010615 ATP/Mg binding site [chemical binding]; other site 337191010616 stacking interactions; other site 337191010617 hinge regions; other site 337191010618 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 337191010619 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 337191010620 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 337191010621 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 337191010622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191010623 active site 337191010624 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 337191010625 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 337191010626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191010627 NAD(P) binding site [chemical binding]; other site 337191010628 active site 337191010629 Bacterial PH domain; Region: bPH_2; cl01348 337191010630 Predicted membrane protein [Function unknown]; Region: COG3428 337191010631 Bacterial PH domain; Region: bPH_2; pfam03703 337191010632 Bacterial PH domain; Region: bPH_2; cl01348 337191010633 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 337191010634 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 337191010635 Chromate transporter; Region: Chromate_transp; pfam02417 337191010636 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 337191010637 Uncharacterized conserved protein [Function unknown]; Region: COG3349 337191010638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191010639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191010640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191010641 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 337191010642 nudix motif; other site 337191010643 Sulfate transporter family; Region: Sulfate_transp; cl19250 337191010644 xanthine permease; Region: pbuX; TIGR03173 337191010645 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 337191010646 active site 337191010647 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 337191010648 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 337191010649 hinge; other site 337191010650 active site 337191010651 Predicted GTPases [General function prediction only]; Region: COG1162 337191010652 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 337191010653 GTPase/Zn-binding domain interface [polypeptide binding]; other site 337191010654 GTP/Mg2+ binding site [chemical binding]; other site 337191010655 G4 box; other site 337191010656 G5 box; other site 337191010657 G1 box; other site 337191010658 Switch I region; other site 337191010659 G2 box; other site 337191010660 G3 box; other site 337191010661 Switch II region; other site 337191010662 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 337191010663 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 337191010664 putative di-iron ligands [ion binding]; other site 337191010665 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 337191010666 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 337191010667 putative di-iron ligands [ion binding]; other site 337191010668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 337191010669 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 337191010670 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 337191010671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191010672 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 337191010673 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191010674 FAD binding pocket [chemical binding]; other site 337191010675 FAD binding motif [chemical binding]; other site 337191010676 phosphate binding motif [ion binding]; other site 337191010677 beta-alpha-beta structure motif; other site 337191010678 NAD binding pocket [chemical binding]; other site 337191010679 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191010680 catalytic loop [active] 337191010681 iron binding site [ion binding]; other site 337191010682 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191010683 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 337191010684 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 337191010685 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 337191010686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 337191010687 nucleotide binding region [chemical binding]; other site 337191010688 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 337191010689 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 337191010690 30S subunit binding site; other site 337191010691 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 337191010692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191010693 active site 337191010694 lipoprotein LpqB; Provisional; Region: PRK13616 337191010695 Sporulation and spore germination; Region: Germane; pfam10646 337191010696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 337191010697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 337191010698 dimerization interface [polypeptide binding]; other site 337191010699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191010700 dimer interface [polypeptide binding]; other site 337191010701 phosphorylation site [posttranslational modification] 337191010702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191010703 ATP binding site [chemical binding]; other site 337191010704 Mg2+ binding site [ion binding]; other site 337191010705 G-X-G motif; other site 337191010706 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 337191010707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191010708 active site 337191010709 phosphorylation site [posttranslational modification] 337191010710 intermolecular recognition site; other site 337191010711 dimerization interface [polypeptide binding]; other site 337191010712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191010713 DNA binding site [nucleotide binding] 337191010714 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 337191010715 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 337191010716 TMP-binding site; other site 337191010717 ATP-binding site [chemical binding]; other site 337191010718 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 337191010719 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 337191010720 homotetramer interface [polypeptide binding]; other site 337191010721 ligand binding site [chemical binding]; other site 337191010722 catalytic site [active] 337191010723 NAD binding site [chemical binding]; other site 337191010724 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 337191010725 Na2 binding site [ion binding]; other site 337191010726 putative substrate binding site 1 [chemical binding]; other site 337191010727 Na binding site 1 [ion binding]; other site 337191010728 putative substrate binding site 2 [chemical binding]; other site 337191010729 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 337191010730 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 337191010731 EspG family; Region: ESX-1_EspG; pfam14011 337191010732 PPE family; Region: PPE; pfam00823 337191010733 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 337191010734 large tegument protein UL36; Provisional; Region: PHA03247 337191010735 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 337191010736 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 337191010737 VirC1 protein; Region: VirC1; cl17401 337191010738 P-loop; other site 337191010739 Magnesium ion binding site [ion binding]; other site 337191010740 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 337191010741 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191010742 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191010743 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191010744 Arsenite-resistance protein 2; Region: ARS2; pfam04959 337191010745 TM2 domain; Region: TM2; pfam05154 337191010746 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 337191010747 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 337191010748 dimerization interface 3.5A [polypeptide binding]; other site 337191010749 active site 337191010750 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 337191010751 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 337191010752 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 337191010753 alphaNTD - beta interaction site [polypeptide binding]; other site 337191010754 alphaNTD homodimer interface [polypeptide binding]; other site 337191010755 alphaNTD - beta' interaction site [polypeptide binding]; other site 337191010756 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 337191010757 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 337191010758 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 337191010759 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 337191010760 RNA binding surface [nucleotide binding]; other site 337191010761 30S ribosomal protein S11; Validated; Region: PRK05309 337191010762 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 337191010763 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 337191010764 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 337191010765 rRNA binding site [nucleotide binding]; other site 337191010766 predicted 30S ribosome binding site; other site 337191010767 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 337191010768 Predicted membrane protein [Function unknown]; Region: COG1950 337191010769 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 337191010770 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 337191010771 putative active site [active] 337191010772 dimerization interface [polypeptide binding]; other site 337191010773 putative tRNAtyr binding site [nucleotide binding]; other site 337191010774 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 337191010775 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 337191010776 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 337191010777 active site 337191010778 adenylate kinase; Reviewed; Region: adk; PRK00279 337191010779 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 337191010780 AMP-binding site [chemical binding]; other site 337191010781 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 337191010782 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 337191010783 SecY translocase; Region: SecY; pfam00344 337191010784 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 337191010785 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 337191010786 23S rRNA binding site [nucleotide binding]; other site 337191010787 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 337191010788 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 337191010789 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 337191010790 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 337191010791 5S rRNA interface [nucleotide binding]; other site 337191010792 L27 interface [polypeptide binding]; other site 337191010793 23S rRNA interface [nucleotide binding]; other site 337191010794 L5 interface [polypeptide binding]; other site 337191010795 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 337191010796 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 337191010797 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 337191010798 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 337191010799 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 337191010800 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 337191010801 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 337191010802 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 337191010803 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 337191010804 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 337191010805 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191010806 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 337191010807 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 337191010808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191010809 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191010810 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 337191010811 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 337191010812 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 337191010813 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 337191010814 putative ADP-binding pocket [chemical binding]; other site 337191010815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191010816 Secretory lipase; Region: LIP; pfam03583 337191010817 GAF domain; Region: GAF; pfam01590 337191010818 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 337191010819 CoA binding domain; Region: CoA_binding; cl17356 337191010820 Bacterial sugar transferase; Region: Bac_transf; pfam02397 337191010821 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 337191010822 putative metal binding site [ion binding]; other site 337191010823 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 337191010824 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191010825 hydrophobic ligand binding site; other site 337191010826 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 337191010827 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 337191010828 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 337191010829 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 337191010830 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 337191010831 RNA binding site [nucleotide binding]; other site 337191010832 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 337191010833 Condensation domain; Region: Condensation; cl19241 337191010834 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010835 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191010836 acyl-activating enzyme (AAE) consensus motif; other site 337191010837 AMP binding site [chemical binding]; other site 337191010838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010839 Condensation domain; Region: Condensation; pfam00668 337191010840 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191010841 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010842 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010843 acyl-activating enzyme (AAE) consensus motif; other site 337191010844 AMP binding site [chemical binding]; other site 337191010845 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010846 Condensation domain; Region: Condensation; cl19241 337191010847 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191010848 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010849 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010850 acyl-activating enzyme (AAE) consensus motif; other site 337191010851 AMP binding site [chemical binding]; other site 337191010852 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010853 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 337191010854 Condensation domain; Region: Condensation; cl19241 337191010855 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010856 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010857 acyl-activating enzyme (AAE) consensus motif; other site 337191010858 AMP binding site [chemical binding]; other site 337191010859 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010860 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 337191010861 MbtH-like protein; Region: MbtH; pfam03621 337191010862 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 337191010863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191010864 Walker A/P-loop; other site 337191010865 ATP binding site [chemical binding]; other site 337191010866 Q-loop/lid; other site 337191010867 ABC transporter signature motif; other site 337191010868 Walker B; other site 337191010869 D-loop; other site 337191010870 H-loop/switch region; other site 337191010871 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191010872 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 337191010873 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 337191010874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191010875 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191010876 DNA binding residues [nucleotide binding] 337191010877 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 337191010878 Anti-sigma-K factor rskA; Region: RskA; pfam10099 337191010879 Putative esterase; Region: Esterase; pfam00756 337191010880 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191010881 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191010882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191010883 DNA binding residues [nucleotide binding] 337191010884 dimerization interface [polypeptide binding]; other site 337191010885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191010886 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 337191010887 DNA binding residues [nucleotide binding] 337191010888 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 337191010889 Pirin-related protein [General function prediction only]; Region: COG1741 337191010890 Pirin; Region: Pirin; pfam02678 337191010891 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 337191010892 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 337191010893 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 337191010894 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 337191010895 gp32 DNA binding protein like; Region: gp32; cl17537 337191010896 tegument protein VP11/12; Provisional; Region: PHA03321 337191010897 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191010898 MbtH-like protein; Region: MbtH; pfam03621 337191010899 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010900 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191010901 acyl-activating enzyme (AAE) consensus motif; other site 337191010902 AMP binding site [chemical binding]; other site 337191010903 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010904 Condensation domain; Region: Condensation; pfam00668 337191010905 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191010906 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010907 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010908 acyl-activating enzyme (AAE) consensus motif; other site 337191010909 AMP binding site [chemical binding]; other site 337191010910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010911 Condensation domain; Region: Condensation; cl19241 337191010912 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 337191010913 Condensation domain; Region: Condensation; cl19241 337191010914 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191010915 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010916 acyl-activating enzyme (AAE) consensus motif; other site 337191010917 AMP binding site [chemical binding]; other site 337191010918 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010919 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 337191010920 Condensation domain; Region: Condensation; pfam00668 337191010921 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010922 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010923 acyl-activating enzyme (AAE) consensus motif; other site 337191010924 AMP binding site [chemical binding]; other site 337191010925 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010926 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191010927 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010928 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191010929 acyl-activating enzyme (AAE) consensus motif; other site 337191010930 AMP binding site [chemical binding]; other site 337191010931 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010932 peptide synthase; Provisional; Region: PRK12467 337191010933 Condensation domain; Region: Condensation; pfam00668 337191010934 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010935 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010936 acyl-activating enzyme (AAE) consensus motif; other site 337191010937 AMP binding site [chemical binding]; other site 337191010938 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010939 Condensation domain; Region: Condensation; pfam00668 337191010940 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010941 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010942 acyl-activating enzyme (AAE) consensus motif; other site 337191010943 AMP binding site [chemical binding]; other site 337191010944 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010945 Condensation domain; Region: Condensation; cl19241 337191010946 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 337191010947 Condensation domain; Region: Condensation; pfam00668 337191010948 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010949 acyl-activating enzyme (AAE) consensus motif; other site 337191010950 AMP binding site [chemical binding]; other site 337191010951 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010952 peptide synthase; Provisional; Region: PRK12467 337191010953 Condensation domain; Region: Condensation; cl19241 337191010954 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010955 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010956 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191010957 acyl-activating enzyme (AAE) consensus motif; other site 337191010958 acyl-activating enzyme (AAE) consensus motif; other site 337191010959 AMP binding site [chemical binding]; other site 337191010960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010961 Condensation domain; Region: Condensation; cl19241 337191010962 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010963 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010964 acyl-activating enzyme (AAE) consensus motif; other site 337191010965 AMP binding site [chemical binding]; other site 337191010966 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010967 Condensation domain; Region: Condensation; cl19241 337191010968 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 337191010969 Condensation domain; Region: Condensation; pfam00668 337191010970 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010971 acyl-activating enzyme (AAE) consensus motif; other site 337191010972 AMP binding site [chemical binding]; other site 337191010973 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010974 Condensation domain; Region: Condensation; pfam00668 337191010975 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191010976 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010977 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010978 acyl-activating enzyme (AAE) consensus motif; other site 337191010979 AMP binding site [chemical binding]; other site 337191010980 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010981 peptide synthase; Provisional; Region: PRK12467 337191010982 Condensation domain; Region: Condensation; cl19241 337191010983 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010984 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010985 acyl-activating enzyme (AAE) consensus motif; other site 337191010986 AMP binding site [chemical binding]; other site 337191010987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010988 Condensation domain; Region: Condensation; cl19241 337191010989 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191010990 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010991 acyl-activating enzyme (AAE) consensus motif; other site 337191010992 AMP binding site [chemical binding]; other site 337191010993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191010994 Condensation domain; Region: Condensation; cl19241 337191010995 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 337191010996 Condensation domain; Region: Condensation; cl19241 337191010997 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191010998 acyl-activating enzyme (AAE) consensus motif; other site 337191010999 AMP binding site [chemical binding]; other site 337191011000 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011001 Condensation domain; Region: Condensation; pfam00668 337191011002 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191011003 Condensation domain; Region: Condensation; cl19241 337191011004 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191011005 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191011006 acyl-activating enzyme (AAE) consensus motif; other site 337191011007 AMP binding site [chemical binding]; other site 337191011008 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011009 Condensation domain; Region: Condensation; cl19241 337191011010 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191011011 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191011012 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 337191011013 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191011014 acyl-activating enzyme (AAE) consensus motif; other site 337191011015 AMP binding site [chemical binding]; other site 337191011016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011017 Condensation domain; Region: Condensation; pfam00668 337191011018 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191011019 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191011020 ABC-2 type transporter; Region: ABC2_membrane; cl17235 337191011021 ABC-2 type transporter; Region: ABC2_membrane; cl17235 337191011022 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191011023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191011024 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 337191011025 Walker A/P-loop; other site 337191011026 ATP binding site [chemical binding]; other site 337191011027 Q-loop/lid; other site 337191011028 ABC transporter signature motif; other site 337191011029 Walker B; other site 337191011030 D-loop; other site 337191011031 H-loop/switch region; other site 337191011032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191011033 active site 337191011034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191011035 Coenzyme A binding pocket [chemical binding]; other site 337191011036 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 337191011037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191011038 ATP binding site [chemical binding]; other site 337191011039 Mg2+ binding site [ion binding]; other site 337191011040 G-X-G motif; other site 337191011041 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 337191011042 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 337191011043 23S rRNA interface [nucleotide binding]; other site 337191011044 putative translocon interaction site; other site 337191011045 signal recognition particle (SRP54) interaction site; other site 337191011046 L23 interface [polypeptide binding]; other site 337191011047 trigger factor interaction site; other site 337191011048 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 337191011049 23S rRNA interface [nucleotide binding]; other site 337191011050 5S rRNA interface [nucleotide binding]; other site 337191011051 putative antibiotic binding site [chemical binding]; other site 337191011052 L25 interface [polypeptide binding]; other site 337191011053 L27 interface [polypeptide binding]; other site 337191011054 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 337191011055 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 337191011056 G-X-X-G motif; other site 337191011057 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 337191011058 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 337191011059 putative translocon binding site; other site 337191011060 protein-rRNA interface [nucleotide binding]; other site 337191011061 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 337191011062 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 337191011063 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 337191011064 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 337191011065 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 337191011066 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 337191011067 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 337191011068 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 337191011069 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191011070 CoenzymeA binding site [chemical binding]; other site 337191011071 subunit interaction site [polypeptide binding]; other site 337191011072 PHB binding site; other site 337191011073 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 337191011074 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 337191011075 active site 337191011076 dimer interface [polypeptide binding]; other site 337191011077 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 337191011078 Ligand Binding Site [chemical binding]; other site 337191011079 Molecular Tunnel; other site 337191011080 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191011081 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 337191011082 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191011083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191011084 DNA-binding site [nucleotide binding]; DNA binding site 337191011085 FCD domain; Region: FCD; pfam07729 337191011086 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 337191011087 Na binding site [ion binding]; other site 337191011088 putative substrate binding site [chemical binding]; other site 337191011089 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191011090 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191011091 short chain dehydrogenase; Provisional; Region: PRK05650 337191011092 classical (c) SDRs; Region: SDR_c; cd05233 337191011093 NAD(P) binding site [chemical binding]; other site 337191011094 active site 337191011095 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 337191011096 dinuclear metal binding motif [ion binding]; other site 337191011097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191011098 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191011099 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 337191011100 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191011101 DNA binding residues [nucleotide binding] 337191011102 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 337191011103 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 337191011104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191011105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191011106 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 337191011107 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 337191011108 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191011109 active site 337191011110 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 337191011111 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191011112 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191011113 classical (c) SDRs; Region: SDR_c; cd05233 337191011114 NAD(P) binding site [chemical binding]; other site 337191011115 active site 337191011116 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 337191011117 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 337191011118 active site 337191011119 substrate binding site [chemical binding]; other site 337191011120 FMN binding site [chemical binding]; other site 337191011121 putative catalytic residues [active] 337191011122 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 337191011123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 337191011124 FeS/SAM binding site; other site 337191011125 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 337191011126 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 337191011127 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 337191011128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191011129 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 337191011130 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 337191011131 FAD binding pocket [chemical binding]; other site 337191011132 FAD binding motif [chemical binding]; other site 337191011133 phosphate binding motif [ion binding]; other site 337191011134 beta-alpha-beta structure motif; other site 337191011135 NAD(p) ribose binding residues [chemical binding]; other site 337191011136 NAD binding pocket [chemical binding]; other site 337191011137 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 337191011138 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191011139 catalytic loop [active] 337191011140 iron binding site [ion binding]; other site 337191011141 Predicted membrane protein [Function unknown]; Region: COG4270 337191011142 A new structural DNA glycosylase; Region: AlkD_like; cd06561 337191011143 active site 337191011144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 337191011145 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191011146 NAD(P) binding site [chemical binding]; other site 337191011147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191011148 Reductase C-terminal; Region: Reductase_C; pfam14759 337191011149 Src Homology 3 domain superfamily; Region: SH3; cl17036 337191011150 peptide ligand binding site [polypeptide binding]; other site 337191011151 short chain dehydrogenase; Provisional; Region: PRK07825 337191011152 classical (c) SDRs; Region: SDR_c; cd05233 337191011153 NAD(P) binding site [chemical binding]; other site 337191011154 active site 337191011155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191011157 O-succinylbenzoate synthase; Provisional; Region: PRK02901 337191011158 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 337191011159 active site 337191011160 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 337191011161 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191011162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191011163 Predicted esterase [General function prediction only]; Region: COG0627 337191011164 Short C-terminal domain; Region: SHOCT; pfam09851 337191011165 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 337191011166 elongation factor Tu; Reviewed; Region: PRK00049 337191011167 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 337191011168 G1 box; other site 337191011169 GEF interaction site [polypeptide binding]; other site 337191011170 GTP/Mg2+ binding site [chemical binding]; other site 337191011171 Switch I region; other site 337191011172 G2 box; other site 337191011173 G3 box; other site 337191011174 Switch II region; other site 337191011175 G4 box; other site 337191011176 G5 box; other site 337191011177 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 337191011178 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 337191011179 Antibiotic Binding Site [chemical binding]; other site 337191011180 elongation factor G; Reviewed; Region: PRK00007 337191011181 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 337191011182 G1 box; other site 337191011183 putative GEF interaction site [polypeptide binding]; other site 337191011184 GTP/Mg2+ binding site [chemical binding]; other site 337191011185 Switch I region; other site 337191011186 G2 box; other site 337191011187 G3 box; other site 337191011188 Switch II region; other site 337191011189 G4 box; other site 337191011190 G5 box; other site 337191011191 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 337191011192 Elongation Factor G, domain II; Region: EFG_II; pfam14492 337191011193 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 337191011194 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 337191011195 30S ribosomal protein S7; Validated; Region: PRK05302 337191011196 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 337191011197 S17 interaction site [polypeptide binding]; other site 337191011198 S8 interaction site; other site 337191011199 16S rRNA interaction site [nucleotide binding]; other site 337191011200 streptomycin interaction site [chemical binding]; other site 337191011201 23S rRNA interaction site [nucleotide binding]; other site 337191011202 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 337191011203 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 337191011204 active site 337191011205 metal binding site A [ion binding]; metal-binding site 337191011206 DNA binding site [nucleotide binding] 337191011207 putative catalytic site [active] 337191011208 putative phosphate binding site [ion binding]; other site 337191011209 putative AP binding site [nucleotide binding]; other site 337191011210 putative metal binding site B [ion binding]; other site 337191011211 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 337191011212 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 337191011213 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 337191011214 HPP family; Region: HPP; pfam04982 337191011215 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 337191011216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 337191011217 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 337191011218 NAD(P) binding site [chemical binding]; other site 337191011219 catalytic residues [active] 337191011220 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 337191011221 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 337191011222 NAD binding site [chemical binding]; other site 337191011223 catalytic Zn binding site [ion binding]; other site 337191011224 substrate binding site [chemical binding]; other site 337191011225 structural Zn binding site [ion binding]; other site 337191011226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011227 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191011228 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191011229 active site 337191011230 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191011231 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191011232 active site 337191011233 TIGR03084 family protein; Region: TIGR03084 337191011234 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 337191011235 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191011236 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 337191011237 CoenzymeA binding site [chemical binding]; other site 337191011238 subunit interaction site [polypeptide binding]; other site 337191011239 PHB binding site; other site 337191011240 acyl-CoA synthetase; Provisional; Region: PRK13388 337191011241 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191011242 acyl-activating enzyme (AAE) consensus motif; other site 337191011243 AMP binding site [chemical binding]; other site 337191011244 active site 337191011245 CoA binding site [chemical binding]; other site 337191011246 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191011247 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191011248 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191011249 classical (c) SDRs; Region: SDR_c; cd05233 337191011250 NAD(P) binding site [chemical binding]; other site 337191011251 active site 337191011252 Ecdysteroid kinase; Region: EcKinase; cl17738 337191011253 Phosphotransferase enzyme family; Region: APH; pfam01636 337191011254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191011255 NAD(P) binding site [chemical binding]; other site 337191011256 active site 337191011257 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 337191011258 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 337191011259 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191011260 classical (c) SDRs; Region: SDR_c; cd05233 337191011261 NAD(P) binding site [chemical binding]; other site 337191011262 active site 337191011263 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 337191011264 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 337191011265 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191011266 short chain dehydrogenase; Provisional; Region: PRK07775 337191011267 classical (c) SDRs; Region: SDR_c; cd05233 337191011268 NAD(P) binding site [chemical binding]; other site 337191011269 active site 337191011270 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191011271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191011273 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 337191011274 NAD binding site [chemical binding]; other site 337191011275 catalytic residues [active] 337191011276 short chain dehydrogenase; Provisional; Region: PRK07774 337191011277 classical (c) SDRs; Region: SDR_c; cd05233 337191011278 NAD(P) binding site [chemical binding]; other site 337191011279 active site 337191011280 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 337191011281 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 337191011282 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 337191011283 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 337191011284 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 337191011285 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191011286 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191011287 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 337191011288 acyl-CoA synthetase; Provisional; Region: PRK13382 337191011289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191011290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191011291 acyl-activating enzyme (AAE) consensus motif; other site 337191011292 acyl-activating enzyme (AAE) consensus motif; other site 337191011293 AMP binding site [chemical binding]; other site 337191011294 active site 337191011295 CoA binding site [chemical binding]; other site 337191011296 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 337191011297 putative acyl-acceptor binding pocket; other site 337191011298 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191011299 CoenzymeA binding site [chemical binding]; other site 337191011300 subunit interaction site [polypeptide binding]; other site 337191011301 PHB binding site; other site 337191011302 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 337191011303 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191011304 NAD(P) binding site [chemical binding]; other site 337191011305 Amidohydrolase; Region: Amidohydro_4; pfam13147 337191011306 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 337191011307 active site 337191011308 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 337191011309 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 337191011310 Walker A/P-loop; other site 337191011311 ATP binding site [chemical binding]; other site 337191011312 Q-loop/lid; other site 337191011313 ABC transporter signature motif; other site 337191011314 Walker B; other site 337191011315 D-loop; other site 337191011316 H-loop/switch region; other site 337191011317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 337191011318 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 337191011319 substrate binding pocket [chemical binding]; other site 337191011320 membrane-bound complex binding site; other site 337191011321 hinge residues; other site 337191011322 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 337191011323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191011324 dimer interface [polypeptide binding]; other site 337191011325 conserved gate region; other site 337191011326 putative PBP binding loops; other site 337191011327 ABC-ATPase subunit interface; other site 337191011328 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 337191011329 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 337191011330 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 337191011331 NAD(P) binding site [chemical binding]; other site 337191011332 Methyltransferase domain; Region: Methyltransf_24; pfam13578 337191011333 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191011334 classical (c) SDRs; Region: SDR_c; cd05233 337191011335 NAD(P) binding site [chemical binding]; other site 337191011336 active site 337191011337 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191011338 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191011339 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191011340 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 337191011341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191011342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191011344 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 337191011345 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 337191011346 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 337191011347 NMT1/THI5 like; Region: NMT1; pfam09084 337191011348 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 337191011349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191011350 dimer interface [polypeptide binding]; other site 337191011351 conserved gate region; other site 337191011352 putative PBP binding loops; other site 337191011353 ABC-ATPase subunit interface; other site 337191011354 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 337191011355 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 337191011356 Walker A/P-loop; other site 337191011357 ATP binding site [chemical binding]; other site 337191011358 Q-loop/lid; other site 337191011359 ABC transporter signature motif; other site 337191011360 Walker B; other site 337191011361 D-loop; other site 337191011362 H-loop/switch region; other site 337191011363 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 337191011364 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 337191011365 Protein of unknown function, DUF608; Region: DUF608; pfam04685 337191011366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191011367 S-adenosylmethionine binding site [chemical binding]; other site 337191011368 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191011369 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 337191011370 Ferredoxin [Energy production and conversion]; Region: COG1146 337191011371 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 337191011372 4Fe-4S binding domain; Region: Fer4; pfam00037 337191011373 ferredoxin-NADP+ reductase; Region: PLN02852 337191011374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191011375 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191011376 active site 2 [active] 337191011377 active site 1 [active] 337191011378 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191011379 active site 2 [active] 337191011380 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 337191011381 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 337191011382 RNA binding surface [nucleotide binding]; other site 337191011383 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 337191011384 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 337191011385 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 337191011386 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 337191011387 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 337191011388 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 337191011389 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 337191011390 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 337191011391 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 337191011392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191011394 Condensation domain; Region: Condensation; cl19241 337191011395 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191011396 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191011397 acyl-activating enzyme (AAE) consensus motif; other site 337191011398 AMP binding site [chemical binding]; other site 337191011399 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011400 Condensation domain; Region: Condensation; cl19241 337191011401 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 337191011402 Condensation domain; Region: Condensation; pfam00668 337191011403 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191011404 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191011405 acyl-activating enzyme (AAE) consensus motif; other site 337191011406 AMP binding site [chemical binding]; other site 337191011407 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011408 Condensation domain; Region: Condensation; cl19241 337191011409 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191011410 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191011411 acyl-activating enzyme (AAE) consensus motif; other site 337191011412 AMP binding site [chemical binding]; other site 337191011413 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011414 Condensation domain; Region: Condensation; pfam00668 337191011415 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191011416 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191011417 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191011418 acyl-activating enzyme (AAE) consensus motif; other site 337191011419 AMP binding site [chemical binding]; other site 337191011420 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011421 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 337191011422 Condensation domain; Region: Condensation; pfam00668 337191011423 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 337191011424 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191011425 acyl-activating enzyme (AAE) consensus motif; other site 337191011426 AMP binding site [chemical binding]; other site 337191011427 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011428 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 337191011429 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 337191011430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191011432 WHG domain; Region: WHG; pfam13305 337191011433 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191011434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191011435 putative DNA binding site [nucleotide binding]; other site 337191011436 putative Zn2+ binding site [ion binding]; other site 337191011437 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191011438 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 337191011439 putative active site [active] 337191011440 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 337191011441 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 337191011442 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 337191011443 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191011444 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191011445 active site 337191011446 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 337191011447 tetrameric interface [polypeptide binding]; other site 337191011448 NAD binding site [chemical binding]; other site 337191011449 catalytic residues [active] 337191011450 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 337191011451 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 337191011452 catalytic core [active] 337191011453 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 337191011454 homodimer interface [polypeptide binding]; other site 337191011455 NAD binding pocket [chemical binding]; other site 337191011456 ATP binding pocket [chemical binding]; other site 337191011457 Mg binding site [ion binding]; other site 337191011458 active-site loop [active] 337191011459 NAD synthetase; Reviewed; Region: nadE; PRK02628 337191011460 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 337191011461 multimer interface [polypeptide binding]; other site 337191011462 active site 337191011463 catalytic triad [active] 337191011464 protein interface 1 [polypeptide binding]; other site 337191011465 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 337191011466 homodimer interface [polypeptide binding]; other site 337191011467 NAD binding pocket [chemical binding]; other site 337191011468 ATP binding pocket [chemical binding]; other site 337191011469 Mg binding site [ion binding]; other site 337191011470 active-site loop [active] 337191011471 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191011472 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 337191011473 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191011474 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 337191011475 active site 337191011476 ATP binding site [chemical binding]; other site 337191011477 substrate binding site [chemical binding]; other site 337191011478 activation loop (A-loop); other site 337191011479 SnoaL-like domain; Region: SnoaL_4; pfam13577 337191011480 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 337191011481 homodimer interface [polypeptide binding]; other site 337191011482 putative substrate binding pocket [chemical binding]; other site 337191011483 diiron center [ion binding]; other site 337191011484 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 337191011485 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 337191011486 FMN binding site [chemical binding]; other site 337191011487 active site 337191011488 catalytic residues [active] 337191011489 substrate binding site [chemical binding]; other site 337191011490 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 337191011491 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 337191011492 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 337191011493 PhoU domain; Region: PhoU; pfam01895 337191011494 PhoU domain; Region: PhoU; pfam01895 337191011495 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 337191011496 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 337191011497 Walker A/P-loop; other site 337191011498 ATP binding site [chemical binding]; other site 337191011499 Q-loop/lid; other site 337191011500 ABC transporter signature motif; other site 337191011501 Walker B; other site 337191011502 D-loop; other site 337191011503 H-loop/switch region; other site 337191011504 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 337191011505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191011506 dimer interface [polypeptide binding]; other site 337191011507 conserved gate region; other site 337191011508 putative PBP binding loops; other site 337191011509 ABC-ATPase subunit interface; other site 337191011510 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 337191011511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191011512 dimer interface [polypeptide binding]; other site 337191011513 conserved gate region; other site 337191011514 putative PBP binding loops; other site 337191011515 ABC-ATPase subunit interface; other site 337191011516 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 337191011517 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 337191011518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 337191011519 active site 337191011520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191011521 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 337191011522 active site 337191011523 catalytic residues [active] 337191011524 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 337191011525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191011526 active site 337191011527 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 337191011528 Ligand binding site; other site 337191011529 Putative Catalytic site; other site 337191011530 DXD motif; other site 337191011531 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 337191011532 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 337191011533 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 337191011534 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191011535 acyl-activating enzyme (AAE) consensus motif; other site 337191011536 AMP binding site [chemical binding]; other site 337191011537 active site 337191011538 CoA binding site [chemical binding]; other site 337191011539 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191011540 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191011541 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191011542 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 337191011543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191011544 Coenzyme A binding pocket [chemical binding]; other site 337191011545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191011546 Coenzyme A binding pocket [chemical binding]; other site 337191011547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 337191011548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191011549 DNA binding site [nucleotide binding] 337191011550 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 337191011551 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 337191011552 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 337191011553 active site residue [active] 337191011554 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 337191011555 active site residue [active] 337191011556 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 337191011557 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 337191011558 heme-binding site [chemical binding]; other site 337191011559 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 337191011560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 337191011561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 337191011562 motif II; other site 337191011563 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 337191011564 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 337191011565 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191011566 mce related protein; Region: MCE; pfam02470 337191011567 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191011568 mce related protein; Region: MCE; pfam02470 337191011569 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 337191011570 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191011571 mce related protein; Region: MCE; pfam02470 337191011572 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191011573 mce related protein; Region: MCE; pfam02470 337191011574 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191011575 mce related protein; Region: MCE; pfam02470 337191011576 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 337191011577 mce related protein; Region: MCE; pfam02470 337191011578 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 337191011579 Permease; Region: Permease; cl00510 337191011580 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 337191011581 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 337191011582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191011583 NAD(P) binding site [chemical binding]; other site 337191011584 active site 337191011585 Divergent 4Fe-4S mono-cluster; Region: Fer4_19; cl01443 337191011586 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191011587 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191011588 active site 337191011589 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191011590 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 337191011591 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191011592 active site 337191011593 acyl-CoA synthetase; Validated; Region: PRK07867 337191011594 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191011595 acyl-activating enzyme (AAE) consensus motif; other site 337191011596 AMP binding site [chemical binding]; other site 337191011597 active site 337191011598 CoA binding site [chemical binding]; other site 337191011599 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 337191011600 Nitronate monooxygenase; Region: NMO; pfam03060 337191011601 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 337191011602 FMN binding site [chemical binding]; other site 337191011603 substrate binding site [chemical binding]; other site 337191011604 putative catalytic residue [active] 337191011605 acyl-CoA synthetase; Validated; Region: PRK07798 337191011606 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191011607 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 337191011608 acyl-activating enzyme (AAE) consensus motif; other site 337191011609 acyl-activating enzyme (AAE) consensus motif; other site 337191011610 putative AMP binding site [chemical binding]; other site 337191011611 putative active site [active] 337191011612 putative CoA binding site [chemical binding]; other site 337191011613 enoyl-CoA hydratase; Provisional; Region: PRK07799 337191011614 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191011615 substrate binding site [chemical binding]; other site 337191011616 oxyanion hole (OAH) forming residues; other site 337191011617 trimer interface [polypeptide binding]; other site 337191011618 PAS fold; Region: PAS_3; pfam08447 337191011619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 337191011620 putative active site [active] 337191011621 heme pocket [chemical binding]; other site 337191011622 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 337191011623 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191011624 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 337191011625 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 337191011626 DUF35 OB-fold domain; Region: DUF35; pfam01796 337191011627 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 337191011628 DUF35 OB-fold domain; Region: DUF35; pfam01796 337191011629 lipid-transfer protein; Provisional; Region: PRK07937 337191011630 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 337191011631 active site 337191011632 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 337191011633 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 337191011634 active site 337191011635 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 337191011636 Uncharacterized conserved protein [Function unknown]; Region: COG2128 337191011637 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 337191011638 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 337191011639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191011640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191011641 DNA binding residues [nucleotide binding] 337191011642 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 337191011643 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191011644 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 337191011645 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191011646 dimer interface [polypeptide binding]; other site 337191011647 active site 337191011648 Domain of unknown function (DUF385); Region: DUF385; pfam04075 337191011649 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 337191011650 TIGR03086 family protein; Region: TIGR03086 337191011651 HTH domain; Region: HTH_11; pfam08279 337191011652 WYL domain; Region: WYL; pfam13280 337191011653 acyl-CoA synthetase; Validated; Region: PRK06188 337191011654 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 337191011655 acyl-activating enzyme (AAE) consensus motif; other site 337191011656 putative AMP binding site [chemical binding]; other site 337191011657 putative active site [active] 337191011658 putative CoA binding site [chemical binding]; other site 337191011659 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 337191011660 primary dimer interface [polypeptide binding]; other site 337191011661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191011662 Coenzyme A binding pocket [chemical binding]; other site 337191011663 SnoaL-like domain; Region: SnoaL_2; pfam12680 337191011664 short chain dehydrogenase; Provisional; Region: PRK07791 337191011665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191011666 NAD(P) binding site [chemical binding]; other site 337191011667 active site 337191011668 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191011669 classical (c) SDRs; Region: SDR_c; cd05233 337191011670 NAD(P) binding site [chemical binding]; other site 337191011671 active site 337191011672 enoyl-CoA hydratase; Provisional; Region: PRK07938 337191011673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191011674 substrate binding site [chemical binding]; other site 337191011675 oxyanion hole (OAH) forming residues; other site 337191011676 trimer interface [polypeptide binding]; other site 337191011677 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 337191011678 Coenzyme A transferase; Region: CoA_trans; cl17247 337191011679 Nitronate monooxygenase; Region: NMO; pfam03060 337191011680 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 337191011681 FMN binding site [chemical binding]; other site 337191011682 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 337191011683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191011684 Walker A/P-loop; other site 337191011685 ATP binding site [chemical binding]; other site 337191011686 Q-loop/lid; other site 337191011687 ABC transporter signature motif; other site 337191011688 Walker B; other site 337191011689 D-loop; other site 337191011690 H-loop/switch region; other site 337191011691 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191011692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191011693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191011694 Walker A/P-loop; other site 337191011695 ATP binding site [chemical binding]; other site 337191011696 Q-loop/lid; other site 337191011697 ABC transporter signature motif; other site 337191011698 Walker B; other site 337191011699 D-loop; other site 337191011700 H-loop/switch region; other site 337191011701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191011702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191011703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191011704 Walker A/P-loop; other site 337191011705 ATP binding site [chemical binding]; other site 337191011706 Q-loop/lid; other site 337191011707 ABC transporter signature motif; other site 337191011708 Walker B; other site 337191011709 D-loop; other site 337191011710 H-loop/switch region; other site 337191011711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191011713 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 337191011714 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 337191011715 NAD(P) binding site [chemical binding]; other site 337191011716 catalytic residues [active] 337191011717 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 337191011718 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191011719 dimer interface [polypeptide binding]; other site 337191011720 active site 337191011721 short chain dehydrogenase; Provisional; Region: PRK07831 337191011722 classical (c) SDRs; Region: SDR_c; cd05233 337191011723 NAD(P) binding site [chemical binding]; other site 337191011724 active site 337191011725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191011726 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 337191011727 active site 337191011728 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 337191011729 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 337191011730 acyl-activating enzyme (AAE) consensus motif; other site 337191011731 putative AMP binding site [chemical binding]; other site 337191011732 putative active site [active] 337191011733 putative CoA binding site [chemical binding]; other site 337191011734 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191011735 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 337191011736 putative active site [active] 337191011737 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 337191011738 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 337191011739 dimer interface [polypeptide binding]; other site 337191011740 putative anticodon binding site; other site 337191011741 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 337191011742 motif 1; other site 337191011743 dimer interface [polypeptide binding]; other site 337191011744 active site 337191011745 motif 2; other site 337191011746 motif 3; other site 337191011747 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 337191011748 active site residue [active] 337191011749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191011750 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 337191011751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011752 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 337191011753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191011754 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191011755 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191011756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191011758 pantothenate kinase; Reviewed; Region: PRK13318 337191011759 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 337191011760 tetramerization interface [polypeptide binding]; other site 337191011761 active site 337191011762 Pantoate-beta-alanine ligase; Region: PanC; cd00560 337191011763 active site 337191011764 ATP-binding site [chemical binding]; other site 337191011765 pantoate-binding site; other site 337191011766 HXXH motif; other site 337191011767 Uncharacterized conserved protein [Function unknown]; Region: COG5495 337191011768 Rossmann-like domain; Region: Rossmann-like; pfam10727 337191011769 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 337191011770 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191011771 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 337191011772 active site 337191011773 ATP binding site [chemical binding]; other site 337191011774 substrate binding site [chemical binding]; other site 337191011775 activation loop (A-loop); other site 337191011776 Sec24-related protein; Provisional; Region: PTZ00395 337191011777 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 337191011778 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 337191011779 catalytic center binding site [active] 337191011780 ATP binding site [chemical binding]; other site 337191011781 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 337191011782 homooctamer interface [polypeptide binding]; other site 337191011783 active site 337191011784 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 337191011785 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 337191011786 substrate binding pocket [chemical binding]; other site 337191011787 dimer interface [polypeptide binding]; other site 337191011788 inhibitor binding site; inhibition site 337191011789 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 337191011790 active site 337191011791 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 337191011792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191011793 Walker A motif; other site 337191011794 ATP binding site [chemical binding]; other site 337191011795 Walker B motif; other site 337191011796 arginine finger; other site 337191011797 Peptidase family M41; Region: Peptidase_M41; pfam01434 337191011798 Psoriasis susceptibility locus 2; Region: SPR1; pfam15356 337191011799 Junctional protein associated with coronary artery disease; Region: JCAD; pfam15351 337191011800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191011801 active site 337191011802 Phage portal protein; Region: Phage_portal; cl19194 337191011803 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 337191011804 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 337191011805 Ligand Binding Site [chemical binding]; other site 337191011806 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 337191011807 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 337191011808 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 337191011809 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 337191011810 dimer interface [polypeptide binding]; other site 337191011811 substrate binding site [chemical binding]; other site 337191011812 metal binding sites [ion binding]; metal-binding site 337191011813 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191011814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191011815 catalytic residue [active] 337191011816 isochorismate synthase DhbC; Validated; Region: PRK06923 337191011817 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 337191011818 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 337191011819 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 337191011820 homodimer interface [polypeptide binding]; other site 337191011821 substrate-cofactor binding pocket; other site 337191011822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191011823 catalytic residue [active] 337191011824 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 337191011825 active site residue [active] 337191011826 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 337191011827 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 337191011828 intersubunit interface [polypeptide binding]; other site 337191011829 ferredoxin-NADP+ reductase; Region: PLN02852 337191011830 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191011831 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 337191011832 ABC-ATPase subunit interface; other site 337191011833 dimer interface [polypeptide binding]; other site 337191011834 putative PBP binding regions; other site 337191011835 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 337191011836 ABC-ATPase subunit interface; other site 337191011837 dimer interface [polypeptide binding]; other site 337191011838 putative PBP binding regions; other site 337191011839 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 337191011840 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 337191011841 Walker A/P-loop; other site 337191011842 ATP binding site [chemical binding]; other site 337191011843 Q-loop/lid; other site 337191011844 ABC transporter signature motif; other site 337191011845 Walker B; other site 337191011846 D-loop; other site 337191011847 H-loop/switch region; other site 337191011848 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 337191011849 Cl- selectivity filter; other site 337191011850 Cl- binding residues [ion binding]; other site 337191011851 pore gating glutamate residue; other site 337191011852 dimer interface [polypeptide binding]; other site 337191011853 H+/Cl- coupling transport residue; other site 337191011854 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191011855 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 337191011856 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191011857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191011858 AsnC family; Region: AsnC_trans_reg; pfam01037 337191011859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191011860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191011861 putative substrate translocation pore; other site 337191011862 Transcriptional regulator [Transcription]; Region: IclR; COG1414 337191011863 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 337191011864 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 337191011865 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 337191011866 PYR/PP interface [polypeptide binding]; other site 337191011867 dimer interface [polypeptide binding]; other site 337191011868 TPP binding site [chemical binding]; other site 337191011869 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 337191011870 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 337191011871 TPP-binding site; other site 337191011872 dimer interface [polypeptide binding]; other site 337191011873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191011874 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191011875 NAD(P) binding site [chemical binding]; other site 337191011876 active site 337191011877 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191011878 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 337191011879 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 337191011880 acyl-activating enzyme (AAE) consensus motif; other site 337191011881 acyl-activating enzyme (AAE) consensus motif; other site 337191011882 putative AMP binding site [chemical binding]; other site 337191011883 putative active site [active] 337191011884 putative CoA binding site [chemical binding]; other site 337191011885 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 337191011886 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 337191011887 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 337191011888 putative di-iron ligands [ion binding]; other site 337191011889 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 337191011890 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191011891 FAD binding pocket [chemical binding]; other site 337191011892 FAD binding motif [chemical binding]; other site 337191011893 phosphate binding motif [ion binding]; other site 337191011894 beta-alpha-beta structure motif; other site 337191011895 NAD binding pocket [chemical binding]; other site 337191011896 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191011897 catalytic loop [active] 337191011898 iron binding site [ion binding]; other site 337191011899 Protein of unknown function (DUF456); Region: DUF456; pfam04306 337191011900 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 337191011901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191011902 ATP-grasp domain; Region: ATP-grasp; pfam02222 337191011903 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 337191011904 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 337191011905 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 337191011906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 337191011907 dimerization interface [polypeptide binding]; other site 337191011908 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 337191011909 cyclase homology domain; Region: CHD; cd07302 337191011910 nucleotidyl binding site; other site 337191011911 metal binding site [ion binding]; metal-binding site 337191011912 dimer interface [polypeptide binding]; other site 337191011913 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 337191011914 GDP-binding site [chemical binding]; other site 337191011915 ACT binding site; other site 337191011916 IMP binding site; other site 337191011917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191011918 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191011919 putative substrate translocation pore; other site 337191011920 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 337191011921 Predicted membrane protein [Function unknown]; Region: COG4129 337191011922 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 337191011923 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 337191011924 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 337191011925 active site 337191011926 intersubunit interface [polypeptide binding]; other site 337191011927 zinc binding site [ion binding]; other site 337191011928 Na+ binding site [ion binding]; other site 337191011929 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 337191011930 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 337191011931 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 337191011932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191011933 active site 337191011934 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 337191011935 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 337191011936 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 337191011937 NAD binding site [chemical binding]; other site 337191011938 ligand binding site [chemical binding]; other site 337191011939 catalytic site [active] 337191011940 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 337191011941 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191011942 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 337191011943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191011944 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 337191011945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191011946 acyl-activating enzyme (AAE) consensus motif; other site 337191011947 AMP binding site [chemical binding]; other site 337191011948 active site 337191011949 CoA binding site [chemical binding]; other site 337191011950 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 337191011951 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191011952 substrate binding site [chemical binding]; other site 337191011953 oxyanion hole (OAH) forming residues; other site 337191011954 trimer interface [polypeptide binding]; other site 337191011955 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191011956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191011957 NAD(P) binding site [chemical binding]; other site 337191011958 active site 337191011959 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191011960 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191011961 AsnC family; Region: AsnC_trans_reg; pfam01037 337191011962 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 337191011963 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191011964 putative DNA binding site [nucleotide binding]; other site 337191011965 putative Zn2+ binding site [ion binding]; other site 337191011966 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 337191011967 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 337191011968 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 337191011969 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 337191011970 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 337191011971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191011972 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191011973 putative substrate translocation pore; other site 337191011974 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 337191011975 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 337191011976 conserved cys residue [active] 337191011977 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191011978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191011979 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 337191011980 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 337191011981 inhibitor-cofactor binding pocket; inhibition site 337191011982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191011983 catalytic residue [active] 337191011984 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 337191011985 FAD binding domain; Region: FAD_binding_4; pfam01565 337191011986 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 337191011987 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 337191011988 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 337191011989 aldehyde dehydrogenase family 2 member; Region: PLN02466 337191011990 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 337191011991 tetramerization interface [polypeptide binding]; other site 337191011992 NAD(P) binding site [chemical binding]; other site 337191011993 catalytic residues [active] 337191011994 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 337191011995 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 337191011996 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 337191011997 active site 337191011998 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 337191011999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191012000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191012001 homodimer interface [polypeptide binding]; other site 337191012002 catalytic residue [active] 337191012003 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 337191012004 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 337191012005 metal binding site [ion binding]; metal-binding site 337191012006 dimer interface [polypeptide binding]; other site 337191012007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012008 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191012009 putative substrate translocation pore; other site 337191012010 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191012011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191012012 DNA-binding site [nucleotide binding]; DNA binding site 337191012013 FCD domain; Region: FCD; pfam07729 337191012014 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 337191012015 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 337191012016 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 337191012017 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 337191012018 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191012019 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191012020 active site 337191012021 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 337191012022 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 337191012023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191012024 active site 337191012025 phosphorylation site [posttranslational modification] 337191012026 intermolecular recognition site; other site 337191012027 dimerization interface [polypeptide binding]; other site 337191012028 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191012029 DNA binding site [nucleotide binding] 337191012030 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 337191012031 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 337191012032 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 337191012033 Ligand Binding Site [chemical binding]; other site 337191012034 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 337191012035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191012036 dimer interface [polypeptide binding]; other site 337191012037 phosphorylation site [posttranslational modification] 337191012038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191012039 ATP binding site [chemical binding]; other site 337191012040 Mg2+ binding site [ion binding]; other site 337191012041 G-X-G motif; other site 337191012042 K+-transporting ATPase, c chain; Region: KdpC; cl00944 337191012043 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 337191012044 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 337191012045 Soluble P-type ATPase [General function prediction only]; Region: COG4087 337191012046 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 337191012047 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 337191012048 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 337191012049 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 337191012050 RNA polymerase sigma factor; Provisional; Region: PRK12519 337191012051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191012052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191012053 DNA binding residues [nucleotide binding] 337191012054 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 337191012055 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 337191012056 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 337191012057 classical (c) SDRs; Region: SDR_c; cd05233 337191012058 NAD(P) binding site [chemical binding]; other site 337191012059 active site 337191012060 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 337191012061 GIY-YIG motif/motif A; other site 337191012062 active site 337191012063 catalytic site [active] 337191012064 metal binding site [ion binding]; metal-binding site 337191012065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012066 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 337191012067 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 337191012068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012069 putative substrate translocation pore; other site 337191012070 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 337191012071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012072 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191012073 classical (c) SDRs; Region: SDR_c; cd05233 337191012074 NAD(P) binding site [chemical binding]; other site 337191012075 active site 337191012076 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191012077 classical (c) SDRs; Region: SDR_c; cd05233 337191012078 NAD(P) binding site [chemical binding]; other site 337191012079 active site 337191012080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191012081 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 337191012082 Walker A motif; other site 337191012083 ATP binding site [chemical binding]; other site 337191012084 Walker B motif; other site 337191012085 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 337191012086 metal ion-dependent adhesion site (MIDAS); other site 337191012087 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191012088 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191012089 active site 337191012090 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 337191012091 Clp amino terminal domain; Region: Clp_N; pfam02861 337191012092 Clp amino terminal domain; Region: Clp_N; pfam02861 337191012093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191012094 Walker A motif; other site 337191012095 ATP binding site [chemical binding]; other site 337191012096 Walker B motif; other site 337191012097 arginine finger; other site 337191012098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191012099 Walker A motif; other site 337191012100 ATP binding site [chemical binding]; other site 337191012101 Walker B motif; other site 337191012102 arginine finger; other site 337191012103 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 337191012104 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 337191012105 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 337191012106 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 337191012107 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 337191012108 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 337191012109 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191012110 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 337191012111 putative metal binding site [ion binding]; other site 337191012112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 337191012113 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191012114 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 337191012115 putative active site; other site 337191012116 putative triphosphate binding site [ion binding]; other site 337191012117 putative metal binding residues [ion binding]; other site 337191012118 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 337191012119 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 337191012120 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 337191012121 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 337191012122 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 337191012123 Ferritin-like domain; Region: Ferritin; pfam00210 337191012124 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 337191012125 metal binding site 2 [ion binding]; metal-binding site 337191012126 putative DNA binding helix; other site 337191012127 metal binding site 1 [ion binding]; metal-binding site 337191012128 dimer interface [polypeptide binding]; other site 337191012129 structural Zn2+ binding site [ion binding]; other site 337191012130 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 337191012131 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 337191012132 dimer interface [polypeptide binding]; other site 337191012133 active site 337191012134 heme binding site [chemical binding]; other site 337191012135 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 337191012136 Condensation domain; Region: Condensation; cl19241 337191012137 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 337191012138 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191012139 acyl-activating enzyme (AAE) consensus motif; other site 337191012140 AMP binding site [chemical binding]; other site 337191012141 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191012142 Condensation domain; Region: Condensation; cl19241 337191012143 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 337191012144 Putative esterase; Region: Esterase; pfam00756 337191012145 Cupin domain; Region: Cupin_2; cl17218 337191012146 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191012147 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 337191012148 active site 337191012149 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 337191012150 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191012151 FMN-binding pocket [chemical binding]; other site 337191012152 flavin binding motif; other site 337191012153 phosphate binding motif [ion binding]; other site 337191012154 beta-alpha-beta structure motif; other site 337191012155 NAD binding pocket [chemical binding]; other site 337191012156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191012157 catalytic loop [active] 337191012158 iron binding site [ion binding]; other site 337191012159 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 337191012160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191012161 non-specific DNA binding site [nucleotide binding]; other site 337191012162 salt bridge; other site 337191012163 sequence-specific DNA binding site [nucleotide binding]; other site 337191012164 Cupin domain; Region: Cupin_2; pfam07883 337191012165 cytosine deaminase; Provisional; Region: PRK05985 337191012166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191012167 active site 337191012168 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 337191012169 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 337191012170 Walker A/P-loop; other site 337191012171 ATP binding site [chemical binding]; other site 337191012172 Q-loop/lid; other site 337191012173 ABC transporter signature motif; other site 337191012174 Walker B; other site 337191012175 D-loop; other site 337191012176 H-loop/switch region; other site 337191012177 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 337191012178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191012179 dimer interface [polypeptide binding]; other site 337191012180 conserved gate region; other site 337191012181 putative PBP binding loops; other site 337191012182 ABC-ATPase subunit interface; other site 337191012183 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 337191012184 FAD binding domain; Region: FAD_binding_4; pfam01565 337191012185 Creatinine amidohydrolase; Region: Creatininase; pfam02633 337191012186 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 337191012187 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 337191012188 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 337191012189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191012190 active site 337191012191 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 337191012192 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191012193 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191012194 active site 337191012195 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 337191012196 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 337191012197 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 337191012198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012199 putative substrate translocation pore; other site 337191012200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191012201 dimerization interface [polypeptide binding]; other site 337191012202 putative DNA binding site [nucleotide binding]; other site 337191012203 putative Zn2+ binding site [ion binding]; other site 337191012204 SCP-2 sterol transfer family; Region: SCP2; cl01225 337191012205 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191012206 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191012207 active site 337191012208 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191012209 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191012210 active site 337191012211 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 337191012212 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191012213 Walker A/P-loop; other site 337191012214 ATP binding site [chemical binding]; other site 337191012215 Q-loop/lid; other site 337191012216 ABC transporter signature motif; other site 337191012217 Walker B; other site 337191012218 D-loop; other site 337191012219 H-loop/switch region; other site 337191012220 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191012221 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 337191012222 Walker A/P-loop; other site 337191012223 ATP binding site [chemical binding]; other site 337191012224 Q-loop/lid; other site 337191012225 ABC transporter signature motif; other site 337191012226 Walker B; other site 337191012227 D-loop; other site 337191012228 H-loop/switch region; other site 337191012229 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 337191012230 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 337191012231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191012232 dimer interface [polypeptide binding]; other site 337191012233 conserved gate region; other site 337191012234 putative PBP binding loops; other site 337191012235 ABC-ATPase subunit interface; other site 337191012236 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 337191012237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191012238 dimer interface [polypeptide binding]; other site 337191012239 conserved gate region; other site 337191012240 putative PBP binding loops; other site 337191012241 ABC-ATPase subunit interface; other site 337191012242 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191012243 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 337191012244 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 337191012245 Sulfatase; Region: Sulfatase; pfam00884 337191012246 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 337191012247 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 337191012248 active site 337191012249 iron coordination sites [ion binding]; other site 337191012250 substrate binding pocket [chemical binding]; other site 337191012251 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 337191012252 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 337191012253 putative di-iron ligands [ion binding]; other site 337191012254 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 337191012255 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 337191012256 active site residue [active] 337191012257 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 337191012258 active site residue [active] 337191012259 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 337191012260 putative active site [active] 337191012261 putative metal binding site [ion binding]; other site 337191012262 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 337191012263 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 337191012264 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 337191012265 active site 337191012266 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 337191012267 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 337191012268 active site 337191012269 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 337191012270 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191012271 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 337191012272 dimerization interface [polypeptide binding]; other site 337191012273 substrate binding pocket [chemical binding]; other site 337191012274 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 337191012275 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 337191012276 iron-sulfur cluster [ion binding]; other site 337191012277 [2Fe-2S] cluster binding site [ion binding]; other site 337191012278 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 337191012279 putative alpha subunit interface [polypeptide binding]; other site 337191012280 putative active site [active] 337191012281 putative substrate binding site [chemical binding]; other site 337191012282 Fe binding site [ion binding]; other site 337191012283 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 337191012284 inter-subunit interface; other site 337191012285 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 337191012286 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191012287 catalytic loop [active] 337191012288 iron binding site [ion binding]; other site 337191012289 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 337191012290 FAD binding pocket [chemical binding]; other site 337191012291 FAD binding motif [chemical binding]; other site 337191012292 phosphate binding motif [ion binding]; other site 337191012293 beta-alpha-beta structure motif; other site 337191012294 NAD binding pocket [chemical binding]; other site 337191012295 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191012296 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 337191012297 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 337191012298 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 337191012299 putative NAD(P) binding site [chemical binding]; other site 337191012300 active site 337191012301 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 337191012302 G1 box; other site 337191012303 GTP/Mg2+ binding site [chemical binding]; other site 337191012304 G2 box; other site 337191012305 Switch I region; other site 337191012306 G3 box; other site 337191012307 Switch II region; other site 337191012308 G4 box; other site 337191012309 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 337191012310 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 337191012311 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191012312 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 337191012313 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 337191012314 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191012315 dimer interface [polypeptide binding]; other site 337191012316 active site 337191012317 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 337191012318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191012319 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 337191012320 dimerization interface [polypeptide binding]; other site 337191012321 substrate binding pocket [chemical binding]; other site 337191012322 enoyl-CoA hydratase; Provisional; Region: PRK05862 337191012323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191012324 substrate binding site [chemical binding]; other site 337191012325 oxyanion hole (OAH) forming residues; other site 337191012326 trimer interface [polypeptide binding]; other site 337191012327 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 337191012328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191012329 substrate binding site [chemical binding]; other site 337191012330 oxyanion hole (OAH) forming residues; other site 337191012331 trimer interface [polypeptide binding]; other site 337191012332 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 337191012333 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 337191012334 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 337191012335 FAD binding pocket [chemical binding]; other site 337191012336 FAD binding motif [chemical binding]; other site 337191012337 phosphate binding motif [ion binding]; other site 337191012338 NAD binding pocket [chemical binding]; other site 337191012339 Predicted membrane protein [Function unknown]; Region: COG2259 337191012340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191012341 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 337191012342 NAD(P) binding site [chemical binding]; other site 337191012343 active site 337191012344 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191012345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191012346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012347 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191012348 putative substrate translocation pore; other site 337191012349 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 337191012350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191012351 DNA-binding site [nucleotide binding]; DNA binding site 337191012352 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 337191012353 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191012354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191012355 active site 337191012356 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 337191012357 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 337191012358 putative active site [active] 337191012359 putative catalytic site [active] 337191012360 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191012361 active site 2 [active] 337191012362 active site 1 [active] 337191012363 CoA-transferase family III; Region: CoA_transf_3; cl19215 337191012364 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 337191012365 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 337191012366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012367 putative substrate translocation pore; other site 337191012368 Transcriptional regulators [Transcription]; Region: FadR; COG2186 337191012369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191012370 DNA-binding site [nucleotide binding]; DNA binding site 337191012371 FCD domain; Region: FCD; pfam07729 337191012372 Cation efflux family; Region: Cation_efflux; cl00316 337191012373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191012374 putative DNA binding site [nucleotide binding]; other site 337191012375 dimerization interface [polypeptide binding]; other site 337191012376 putative Zn2+ binding site [ion binding]; other site 337191012377 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 337191012378 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 337191012379 intersubunit interface [polypeptide binding]; other site 337191012380 Secretory lipase; Region: LIP; pfam03583 337191012381 oxidoreductase; Provisional; Region: PRK06128 337191012382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191012383 NAD(P) binding site [chemical binding]; other site 337191012384 active site 337191012385 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 337191012386 PAS fold; Region: PAS_3; pfam08447 337191012387 putative active site [active] 337191012388 heme pocket [chemical binding]; other site 337191012389 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 337191012390 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 337191012391 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 337191012392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191012393 putative ADP-binding pocket [chemical binding]; other site 337191012394 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 337191012395 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191012396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 337191012397 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 337191012398 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 337191012399 NAD binding site [chemical binding]; other site 337191012400 catalytic Zn binding site [ion binding]; other site 337191012401 structural Zn binding site [ion binding]; other site 337191012402 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 337191012403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191012404 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 337191012405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191012406 DNA binding residues [nucleotide binding] 337191012407 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366 337191012408 GAF domain; Region: GAF_2; pfam13185 337191012409 ANTAR domain; Region: ANTAR; pfam03861 337191012410 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191012411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191012412 active site 337191012413 Transcriptional regulators [Transcription]; Region: PurR; COG1609 337191012414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 337191012415 DNA binding site [nucleotide binding] 337191012416 domain linker motif; other site 337191012417 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 337191012418 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 337191012419 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 337191012420 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 337191012421 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 337191012422 substrate binding site [chemical binding]; other site 337191012423 ATP binding site [chemical binding]; other site 337191012424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 337191012425 AAA domain; Region: AAA_33; pfam13671 337191012426 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 337191012427 methionine sulfoxide reductase A; Provisional; Region: PRK14054 337191012428 methionine sulfoxide reductase B; Provisional; Region: PRK00222 337191012429 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 337191012430 hydrophobic ligand binding site; other site 337191012431 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 337191012432 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 337191012433 ATP-grasp domain; Region: ATP-grasp_4; cl17255 337191012434 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 337191012435 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 337191012436 carboxyltransferase (CT) interaction site; other site 337191012437 biotinylation site [posttranslational modification]; other site 337191012438 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 337191012439 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191012440 active site 2 [active] 337191012441 active site 1 [active] 337191012442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012444 short chain dehydrogenase; Validated; Region: PRK08264 337191012445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191012446 NAD(P) binding site [chemical binding]; other site 337191012447 active site 337191012448 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191012449 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191012450 TAP-like protein; Region: Abhydrolase_4; pfam08386 337191012451 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 337191012452 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 337191012453 putative NAD(P) binding site [chemical binding]; other site 337191012454 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 337191012455 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191012456 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 337191012457 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 337191012458 heme-binding site [chemical binding]; other site 337191012459 phosphoenolpyruvate synthase; Validated; Region: PRK06241 337191012460 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 337191012461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191012462 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 337191012463 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191012464 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191012465 Proline dehydrogenase; Region: Pro_dh; pfam01619 337191012466 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 337191012467 active site 337191012468 catalytic residues [active] 337191012469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012471 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 337191012472 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191012473 active site 337191012474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191012475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191012476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 337191012477 dimerization interface [polypeptide binding]; other site 337191012478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 337191012479 metal binding site [ion binding]; metal-binding site 337191012480 active site 337191012481 I-site; other site 337191012482 FAD binding domain; Region: FAD_binding_4; pfam01565 337191012483 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 337191012484 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 337191012485 Domain of unknown function (DUF385); Region: DUF385; cl04387 337191012486 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191012487 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191012488 active site 337191012489 ATP binding site [chemical binding]; other site 337191012490 substrate binding site [chemical binding]; other site 337191012491 activation loop (A-loop); other site 337191012492 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 337191012493 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 337191012494 heme-binding site [chemical binding]; other site 337191012495 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 337191012496 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 337191012497 FAD binding pocket [chemical binding]; other site 337191012498 FAD binding motif [chemical binding]; other site 337191012499 phosphate binding motif [ion binding]; other site 337191012500 beta-alpha-beta structure motif; other site 337191012501 NAD binding pocket [chemical binding]; other site 337191012502 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191012503 hydrophobic ligand binding site; other site 337191012504 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191012505 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 337191012506 DNA binding residues [nucleotide binding] 337191012507 putative dimer interface [polypeptide binding]; other site 337191012508 chaperone protein DnaJ; Provisional; Region: PRK14279 337191012509 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 337191012510 HSP70 interaction site [polypeptide binding]; other site 337191012511 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 337191012512 Zn binding sites [ion binding]; other site 337191012513 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 337191012514 dimer interface [polypeptide binding]; other site 337191012515 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 337191012516 dimer interface [polypeptide binding]; other site 337191012517 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 337191012518 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 337191012519 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 337191012520 nucleotide binding site [chemical binding]; other site 337191012521 NEF interaction site [polypeptide binding]; other site 337191012522 SBD interface [polypeptide binding]; other site 337191012523 SKIP/SNW domain; Region: SKIP_SNW; pfam02731 337191012524 PQQ-like domain; Region: PQQ_2; pfam13360 337191012525 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 337191012526 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191012527 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191012528 active site 337191012529 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 337191012530 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 337191012531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 337191012532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191012533 Walker A motif; other site 337191012534 ATP binding site [chemical binding]; other site 337191012535 Walker B motif; other site 337191012536 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 337191012537 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 337191012538 active site 337191012539 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 337191012540 active site 337191012541 Predicted membrane protein [Function unknown]; Region: COG4270 337191012542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191012544 putative substrate translocation pore; other site 337191012545 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191012546 Protein of unknown function (DUF3525); Region: DUF3525; pfam12039 337191012547 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 337191012548 hydrophobic ligand binding site; other site 337191012549 GAF domain; Region: GAF_2; pfam13185 337191012550 ANTAR domain; Region: ANTAR; pfam03861 337191012551 Cutinase; Region: Cutinase; pfam01083 337191012552 Cytochrome P450; Region: p450; cl12078 337191012553 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 337191012554 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 337191012555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012556 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191012557 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191012558 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 337191012559 [2Fe-2S] cluster binding site [ion binding]; other site 337191012560 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 337191012561 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 337191012562 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 337191012563 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 337191012564 putative NAD(P) binding site [chemical binding]; other site 337191012565 active site 337191012566 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 337191012567 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 337191012568 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 337191012569 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 337191012570 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 337191012571 putative active site [active] 337191012572 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191012573 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 337191012574 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 337191012575 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 337191012576 Cysteine-rich domain; Region: CCG; pfam02754 337191012577 Cysteine-rich domain; Region: CCG; pfam02754 337191012578 aminotransferase AlaT; Validated; Region: PRK09265 337191012579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 337191012580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 337191012581 homodimer interface [polypeptide binding]; other site 337191012582 catalytic residue [active] 337191012583 short chain dehydrogenase; Validated; Region: PRK05855 337191012584 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191012585 classical (c) SDRs; Region: SDR_c; cd05233 337191012586 NAD(P) binding site [chemical binding]; other site 337191012587 active site 337191012588 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 337191012589 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191012590 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 337191012591 FMN-binding pocket [chemical binding]; other site 337191012592 flavin binding motif; other site 337191012593 phosphate binding motif [ion binding]; other site 337191012594 beta-alpha-beta structure motif; other site 337191012595 NAD binding pocket [chemical binding]; other site 337191012596 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191012597 catalytic loop [active] 337191012598 iron binding site [ion binding]; other site 337191012599 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 337191012600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012601 putative substrate translocation pore; other site 337191012602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012604 WHG domain; Region: WHG; pfam13305 337191012605 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 337191012606 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 337191012607 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 337191012608 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 337191012609 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 337191012610 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 337191012611 trimer interface [polypeptide binding]; other site 337191012612 active site 337191012613 Integrase core domain; Region: rve; pfam00665 337191012614 Integrase core domain; Region: rve_3; pfam13683 337191012615 lysine transporter; Provisional; Region: PRK10836 337191012616 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191012617 hydrophobic ligand binding site; other site 337191012618 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 337191012619 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 337191012620 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 337191012621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 337191012622 dimerization interface [polypeptide binding]; other site 337191012623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191012624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012626 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 337191012627 Predicted membrane protein [Function unknown]; Region: COG2311 337191012628 Protein of unknown function (DUF418); Region: DUF418; cl12135 337191012629 transcription termination factor Rho; Provisional; Region: PRK12678 337191012630 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 337191012631 MMPL family; Region: MMPL; cl14618 337191012632 MMPL family; Region: MMPL; cl14618 337191012633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012635 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 337191012636 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 337191012637 active site 337191012638 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 337191012639 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 337191012640 TM-ABC transporter signature motif; other site 337191012641 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 337191012642 TM-ABC transporter signature motif; other site 337191012643 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 337191012644 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 337191012645 Walker A/P-loop; other site 337191012646 ATP binding site [chemical binding]; other site 337191012647 Q-loop/lid; other site 337191012648 ABC transporter signature motif; other site 337191012649 Walker B; other site 337191012650 D-loop; other site 337191012651 H-loop/switch region; other site 337191012652 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 337191012653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191012654 Walker A/P-loop; other site 337191012655 ATP binding site [chemical binding]; other site 337191012656 Q-loop/lid; other site 337191012657 ABC transporter signature motif; other site 337191012658 Walker B; other site 337191012659 D-loop; other site 337191012660 H-loop/switch region; other site 337191012661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012663 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 337191012664 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 337191012665 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 337191012666 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 337191012667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012668 putative substrate translocation pore; other site 337191012669 hypothetical protein; Provisional; Region: PRK06849 337191012670 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 337191012671 ATP-grasp domain; Region: ATP-grasp_4; cl17255 337191012672 Predicted DNA-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG1571 337191012673 SnoaL-like domain; Region: SnoaL_4; pfam13577 337191012674 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191012675 active site 337191012676 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 337191012677 AAA domain; Region: AAA_22; pfam13401 337191012678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191012679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191012680 DNA binding residues [nucleotide binding] 337191012681 dimerization interface [polypeptide binding]; other site 337191012682 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 337191012683 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 337191012684 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 337191012685 Walker A/P-loop; other site 337191012686 ATP binding site [chemical binding]; other site 337191012687 Q-loop/lid; other site 337191012688 ABC transporter signature motif; other site 337191012689 Walker B; other site 337191012690 D-loop; other site 337191012691 H-loop/switch region; other site 337191012692 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 337191012693 ThiS interaction site; other site 337191012694 putative active site [active] 337191012695 tetramer interface [polypeptide binding]; other site 337191012696 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 337191012697 thiS-thiF/thiG interaction site; other site 337191012698 FAD dependent oxidoreductase; Region: DAO; pfam01266 337191012699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191012700 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 337191012701 thiamine phosphate binding site [chemical binding]; other site 337191012702 active site 337191012703 pyrophosphate binding site [ion binding]; other site 337191012704 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 337191012705 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 337191012706 nudix motif; other site 337191012707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 337191012708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 337191012709 substrate binding pocket [chemical binding]; other site 337191012710 membrane-bound complex binding site; other site 337191012711 hinge residues; other site 337191012712 Protein kinase domain; Region: Pkinase; pfam00069 337191012713 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191012714 active site 337191012715 ATP binding site [chemical binding]; other site 337191012716 substrate binding site [chemical binding]; other site 337191012717 activation loop (A-loop); other site 337191012718 Tetratricopeptide repeat; Region: TPR_16; pfam13432 337191012719 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191012720 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191012721 active site 337191012722 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 337191012723 phosphate acetyltransferase; Reviewed; Region: PRK05632 337191012724 DRTGG domain; Region: DRTGG; pfam07085 337191012725 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 337191012726 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 337191012727 FAD binding domain; Region: FAD_binding_4; pfam01565 337191012728 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 337191012729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012730 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 337191012731 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 337191012732 EamA-like transporter family; Region: EamA; pfam00892 337191012733 EamA-like transporter family; Region: EamA; pfam00892 337191012734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191012735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191012736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 337191012737 dimerization interface [polypeptide binding]; other site 337191012738 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191012739 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191012740 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191012741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191012742 DNA-binding site [nucleotide binding]; DNA binding site 337191012743 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 337191012744 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 337191012745 Na binding site [ion binding]; other site 337191012746 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 337191012747 catalytic triad [active] 337191012748 conserved cis-peptide bond; other site 337191012749 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191012750 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191012751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191012752 Walker A/P-loop; other site 337191012753 ATP binding site [chemical binding]; other site 337191012754 Q-loop/lid; other site 337191012755 ABC transporter signature motif; other site 337191012756 Walker B; other site 337191012757 D-loop; other site 337191012758 H-loop/switch region; other site 337191012759 Domain of unknown function (DUF202); Region: DUF202; cl09954 337191012760 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 337191012761 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191012762 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191012763 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 337191012764 acyl-activating enzyme (AAE) consensus motif; other site 337191012765 AMP binding site [chemical binding]; other site 337191012766 active site 337191012767 CoA binding site [chemical binding]; other site 337191012768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 337191012769 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 337191012770 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 337191012771 putative trimer interface [polypeptide binding]; other site 337191012772 putative CoA binding site [chemical binding]; other site 337191012773 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 337191012774 putative trimer interface [polypeptide binding]; other site 337191012775 putative CoA binding site [chemical binding]; other site 337191012776 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 337191012777 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 337191012778 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191012779 active site 1 [active] 337191012780 active site 2 [active] 337191012781 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 337191012782 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191012783 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191012784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012786 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 337191012787 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 337191012788 active site 337191012789 catalytic tetrad [active] 337191012790 Domain of unknown function (DUF385); Region: DUF385; pfam04075 337191012791 Homeodomain-like domain; Region: HTH_23; cl17451 337191012792 Winged helix-turn helix; Region: HTH_29; pfam13551 337191012793 Integrase core domain; Region: rve; pfam00665 337191012794 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191012795 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 337191012796 DNA binding residues [nucleotide binding] 337191012797 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 337191012798 beta-clamp/clamp loader binding surface; other site 337191012799 beta-clamp/translesion DNA polymerase binding surface; other site 337191012800 Domain of unknown function (DUF305); Region: DUF305; pfam03713 337191012801 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 337191012802 active site 337191012803 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 337191012804 endonuclease IV; Provisional; Region: PRK01060 337191012805 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 337191012806 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 337191012807 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191012808 active site 337191012809 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 337191012810 U5 snRNP spliceosome subunit [RNA processing and modification]; Region: PRP8; COG5178 337191012811 Glycerate kinase family; Region: Gly_kinase; cl00841 337191012812 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 337191012813 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 337191012814 transmembrane helices; other site 337191012815 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 337191012816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191012817 NAD(P) binding site [chemical binding]; other site 337191012818 active site 337191012819 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 337191012820 VanW like protein; Region: VanW; pfam04294 337191012821 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 337191012822 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191012823 dimer interface [polypeptide binding]; other site 337191012824 active site 337191012825 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 337191012826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191012827 NAD(P) binding site [chemical binding]; other site 337191012828 active site 337191012829 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191012830 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 337191012831 active site 2 [active] 337191012832 active site 1 [active] 337191012833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012835 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 337191012836 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191012837 Ligand Binding Site [chemical binding]; other site 337191012838 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 337191012839 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 337191012840 conserved cys residue [active] 337191012841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191012842 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 337191012843 DJ-1 family protein; Region: not_thiJ; TIGR01383 337191012844 conserved cys residue [active] 337191012845 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 337191012846 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 337191012847 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 337191012848 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 337191012849 putative hydrophobic ligand binding site [chemical binding]; other site 337191012850 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 337191012851 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 337191012852 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 337191012853 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 337191012854 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 337191012855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191012856 S-adenosylmethionine binding site [chemical binding]; other site 337191012857 Integrase core domain; Region: rve; pfam00665 337191012858 Integrase core domain; Region: rve_3; pfam13683 337191012859 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 337191012860 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 337191012861 FtsX-like permease family; Region: FtsX; pfam02687 337191012862 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 337191012863 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 337191012864 FtsX-like permease family; Region: FtsX; pfam02687 337191012865 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 337191012866 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 337191012867 Walker A/P-loop; other site 337191012868 ATP binding site [chemical binding]; other site 337191012869 Q-loop/lid; other site 337191012870 ABC transporter signature motif; other site 337191012871 Walker B; other site 337191012872 D-loop; other site 337191012873 H-loop/switch region; other site 337191012874 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 337191012875 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 337191012876 active site 337191012877 substrate-binding site [chemical binding]; other site 337191012878 metal-binding site [ion binding] 337191012879 GTP binding site [chemical binding]; other site 337191012880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191012881 S-adenosylmethionine binding site [chemical binding]; other site 337191012882 LabA_like proteins; Region: LabA_like; cd06167 337191012883 putative metal binding site [ion binding]; other site 337191012884 MMPL family; Region: MMPL; cl14618 337191012885 Transport protein; Region: actII; TIGR00833 337191012886 MMPL family; Region: MMPL; cl14618 337191012887 RecX family; Region: RecX; cl00936 337191012888 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 337191012889 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 337191012890 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 337191012891 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191012892 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 337191012893 NAD(P) binding site [chemical binding]; other site 337191012894 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 337191012895 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 337191012896 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 337191012897 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 337191012898 dimerization interface [polypeptide binding]; other site 337191012899 active site 337191012900 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 337191012901 pyruvate carboxylase; Reviewed; Region: PRK12999 337191012902 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 337191012903 ATP-grasp domain; Region: ATP-grasp_4; cl17255 337191012904 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 337191012905 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 337191012906 active site 337191012907 catalytic residues [active] 337191012908 metal binding site [ion binding]; metal-binding site 337191012909 homodimer binding site [polypeptide binding]; other site 337191012910 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 337191012911 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 337191012912 carboxyltransferase (CT) interaction site; other site 337191012913 biotinylation site [posttranslational modification]; other site 337191012914 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 337191012915 FMN binding site [chemical binding]; other site 337191012916 dimer interface [polypeptide binding]; other site 337191012917 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191012918 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 337191012919 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 337191012920 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 337191012921 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191012922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191012923 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191012924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191012925 AMP-binding domain protein; Validated; Region: PRK08315 337191012926 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 337191012927 acyl-activating enzyme (AAE) consensus motif; other site 337191012928 putative AMP binding site [chemical binding]; other site 337191012929 putative active site [active] 337191012930 putative CoA binding site [chemical binding]; other site 337191012931 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 337191012932 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 337191012933 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191012934 classical (c) SDRs; Region: SDR_c; cd05233 337191012935 NAD(P) binding site [chemical binding]; other site 337191012936 active site 337191012937 SnoaL-like domain; Region: SnoaL_4; pfam13577 337191012938 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191012939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191012940 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191012941 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 337191012942 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 337191012943 NAD binding site [chemical binding]; other site 337191012944 catalytic residues [active] 337191012945 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 337191012946 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 337191012947 NAD binding site [chemical binding]; other site 337191012948 catalytic Zn binding site [ion binding]; other site 337191012949 substrate binding site [chemical binding]; other site 337191012950 structural Zn binding site [ion binding]; other site 337191012951 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 337191012952 metal binding site [ion binding]; metal-binding site 337191012953 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 337191012954 DUF35 OB-fold domain; Region: DUF35; pfam01796 337191012955 lipid-transfer protein; Provisional; Region: PRK07855 337191012956 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 337191012957 active site 337191012958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191012959 metabolite-proton symporter; Region: 2A0106; TIGR00883 337191012960 putative substrate translocation pore; other site 337191012961 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191012962 enoyl-CoA hydratase; Provisional; Region: PRK07799 337191012963 substrate binding site [chemical binding]; other site 337191012964 oxyanion hole (OAH) forming residues; other site 337191012965 trimer interface [polypeptide binding]; other site 337191012966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191012967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191012968 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 337191012969 classical (c) SDRs; Region: SDR_c; cd05233 337191012970 NAD(P) binding site [chemical binding]; other site 337191012971 active site 337191012972 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 337191012973 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191012974 dimer interface [polypeptide binding]; other site 337191012975 active site 337191012976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 337191012977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191012978 NAD(P) binding site [chemical binding]; other site 337191012979 active site 337191012980 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 337191012981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191012982 NAD(P) binding site [chemical binding]; other site 337191012983 active site 337191012984 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 337191012985 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 337191012986 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191012987 active site 337191012988 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 337191012989 4-coumarate--CoA ligase; Region: PLN02246 337191012990 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191012991 acyl-activating enzyme (AAE) consensus motif; other site 337191012992 AMP binding site [chemical binding]; other site 337191012993 active site 337191012994 CoA binding site [chemical binding]; other site 337191012995 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 337191012996 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 337191012997 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 337191012998 putative active site [active] 337191012999 putative catalytic site [active] 337191013000 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191013001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191013002 active site 337191013003 phosphorylation site [posttranslational modification] 337191013004 intermolecular recognition site; other site 337191013005 dimerization interface [polypeptide binding]; other site 337191013006 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 337191013007 DNA binding residues [nucleotide binding] 337191013008 dimerization interface [polypeptide binding]; other site 337191013009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 337191013010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191013011 ATP binding site [chemical binding]; other site 337191013012 Mg2+ binding site [ion binding]; other site 337191013013 G-X-G motif; other site 337191013014 Domain of unknown function DUF20; Region: UPF0118; pfam01594 337191013015 Predicted integral membrane protein [Function unknown]; Region: COG0392 337191013016 UL14 tegument protein; Provisional; Region: PHA03185 337191013017 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 337191013018 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 337191013019 Pirin; Region: Pirin; pfam02678 337191013020 Pirin-related protein [General function prediction only]; Region: COG1741 337191013021 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191013022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191013023 DNA-binding site [nucleotide binding]; DNA binding site 337191013024 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 337191013025 xanthine permease; Region: pbuX; TIGR03173 337191013026 Sulfate transporter family; Region: Sulfate_transp; cl19250 337191013027 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 337191013028 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 337191013029 catalytic triad [active] 337191013030 conserved cis-peptide bond; other site 337191013031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191013032 allophanate hydrolase; Provisional; Region: PRK08186 337191013033 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 337191013034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191013035 NAD(P) binding site [chemical binding]; other site 337191013036 active site 337191013037 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 337191013038 Transcriptional regulators [Transcription]; Region: FadR; COG2186 337191013039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191013040 DNA-binding site [nucleotide binding]; DNA binding site 337191013041 FCD domain; Region: FCD; pfam07729 337191013042 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 337191013043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013044 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 337191013045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191013046 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 337191013047 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 337191013048 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 337191013049 active site 337191013050 Zn binding site [ion binding]; other site 337191013051 Ion channel; Region: Ion_trans_2; pfam07885 337191013052 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 337191013053 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 337191013054 NAD binding site [chemical binding]; other site 337191013055 catalytic Zn binding site [ion binding]; other site 337191013056 substrate binding site [chemical binding]; other site 337191013057 structural Zn binding site [ion binding]; other site 337191013058 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 337191013059 active site 337191013060 diiron metal binding site [ion binding]; other site 337191013061 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 337191013062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191013063 Walker A/P-loop; other site 337191013064 ATP binding site [chemical binding]; other site 337191013065 Q-loop/lid; other site 337191013066 ABC transporter signature motif; other site 337191013067 Walker B; other site 337191013068 D-loop; other site 337191013069 H-loop/switch region; other site 337191013070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191013071 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 337191013072 Walker A/P-loop; other site 337191013073 ATP binding site [chemical binding]; other site 337191013074 Q-loop/lid; other site 337191013075 ABC transporter signature motif; other site 337191013076 Walker B; other site 337191013077 D-loop; other site 337191013078 H-loop/switch region; other site 337191013079 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 337191013080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191013081 dimer interface [polypeptide binding]; other site 337191013082 conserved gate region; other site 337191013083 putative PBP binding loops; other site 337191013084 ABC-ATPase subunit interface; other site 337191013085 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 337191013086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191013087 dimer interface [polypeptide binding]; other site 337191013088 conserved gate region; other site 337191013089 putative PBP binding loops; other site 337191013090 ABC-ATPase subunit interface; other site 337191013091 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 337191013092 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 337191013093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191013094 dimerization interface [polypeptide binding]; other site 337191013095 putative DNA binding site [nucleotide binding]; other site 337191013096 putative Zn2+ binding site [ion binding]; other site 337191013097 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 337191013098 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191013099 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191013100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191013101 dimerization interface [polypeptide binding]; other site 337191013102 putative Zn2+ binding site [ion binding]; other site 337191013103 putative DNA binding site [nucleotide binding]; other site 337191013104 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 337191013105 NAD(P) binding site [chemical binding]; other site 337191013106 catalytic residues [active] 337191013107 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 337191013108 homotrimer interaction site [polypeptide binding]; other site 337191013109 putative active site [active] 337191013110 Cupin domain; Region: Cupin_2; pfam07883 337191013111 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191013112 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 337191013113 FMN-binding pocket [chemical binding]; other site 337191013114 flavin binding motif; other site 337191013115 phosphate binding motif [ion binding]; other site 337191013116 beta-alpha-beta structure motif; other site 337191013117 NAD binding pocket [chemical binding]; other site 337191013118 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191013119 catalytic loop [active] 337191013120 iron binding site [ion binding]; other site 337191013121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 337191013122 active site 337191013123 metal binding site [ion binding]; metal-binding site 337191013124 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 337191013125 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 337191013126 active site 337191013127 metal binding site [ion binding]; metal-binding site 337191013128 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191013129 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191013130 short chain dehydrogenase; Provisional; Region: PRK12939 337191013131 classical (c) SDRs; Region: SDR_c; cd05233 337191013132 NAD(P) binding site [chemical binding]; other site 337191013133 active site 337191013134 short chain dehydrogenase; Provisional; Region: PRK07062 337191013135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191013136 NAD(P) binding site [chemical binding]; other site 337191013137 active site 337191013138 hypothetical protein; Provisional; Region: PRK07064 337191013139 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 337191013140 PYR/PP interface [polypeptide binding]; other site 337191013141 dimer interface [polypeptide binding]; other site 337191013142 TPP binding site [chemical binding]; other site 337191013143 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 337191013144 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 337191013145 TPP-binding site [chemical binding]; other site 337191013146 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 337191013147 iron-sulfur cluster [ion binding]; other site 337191013148 [2Fe-2S] cluster binding site [ion binding]; other site 337191013149 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 337191013150 hydrophobic ligand binding site; other site 337191013151 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 337191013152 homotrimer interaction site [polypeptide binding]; other site 337191013153 putative active site [active] 337191013154 benzoate transport; Region: 2A0115; TIGR00895 337191013155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191013156 putative substrate translocation pore; other site 337191013157 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u2; cd13438 337191013158 prohibitin homologues; Region: PHB; smart00244 337191013159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191013160 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 337191013161 substrate binding site [chemical binding]; other site 337191013162 oxyanion hole (OAH) forming residues; other site 337191013163 trimer interface [polypeptide binding]; other site 337191013164 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 337191013165 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 337191013166 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 337191013167 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 337191013168 dimer interface [polypeptide binding]; other site 337191013169 active site 337191013170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013174 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 337191013175 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 337191013176 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191013177 active site 337191013178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013180 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 337191013181 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 337191013182 phosphate binding site [ion binding]; other site 337191013183 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 337191013184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013185 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 337191013186 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191013187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191013188 NAD(P) binding site [chemical binding]; other site 337191013189 active site 337191013190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191013191 dimer interface [polypeptide binding]; other site 337191013192 conserved gate region; other site 337191013193 putative PBP binding loops; other site 337191013194 ABC-ATPase subunit interface; other site 337191013195 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 337191013196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191013197 dimer interface [polypeptide binding]; other site 337191013198 conserved gate region; other site 337191013199 putative PBP binding loops; other site 337191013200 ABC-ATPase subunit interface; other site 337191013201 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 337191013202 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 337191013203 Walker A/P-loop; other site 337191013204 ATP binding site [chemical binding]; other site 337191013205 Q-loop/lid; other site 337191013206 ABC transporter signature motif; other site 337191013207 Walker B; other site 337191013208 D-loop; other site 337191013209 H-loop/switch region; other site 337191013210 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191013211 classical (c) SDRs; Region: SDR_c; cd05233 337191013212 NAD(P) binding site [chemical binding]; other site 337191013213 active site 337191013214 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 337191013215 SnoaL-like domain; Region: SnoaL_2; pfam12680 337191013216 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 337191013217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 337191013218 substrate binding site [chemical binding]; other site 337191013219 oxyanion hole (OAH) forming residues; other site 337191013220 trimer interface [polypeptide binding]; other site 337191013221 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 337191013222 DUF35 OB-fold domain; Region: DUF35; pfam01796 337191013223 lipid-transfer protein; Provisional; Region: PRK08256 337191013224 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 337191013225 active site 337191013226 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191013227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191013228 active site 337191013229 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 337191013230 Phosphotransferase enzyme family; Region: APH; pfam01636 337191013231 putative active site [active] 337191013232 putative substrate binding site [chemical binding]; other site 337191013233 ATP binding site [chemical binding]; other site 337191013234 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191013235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191013236 active site 337191013237 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 337191013238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191013239 NAD(P) binding site [chemical binding]; other site 337191013240 active site 337191013241 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 337191013242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191013243 NAD(P) binding site [chemical binding]; other site 337191013244 active site 337191013245 EthD domain; Region: EthD; cl17553 337191013246 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 337191013247 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 337191013248 Prostaglandin dehydrogenases; Region: PGDH; cd05288 337191013249 NAD(P) binding site [chemical binding]; other site 337191013250 substrate binding site [chemical binding]; other site 337191013251 dimer interface [polypeptide binding]; other site 337191013252 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 337191013253 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191013254 NAD(P) binding site [chemical binding]; other site 337191013255 tricarballylate dehydrogenase; Validated; Region: PRK08274 337191013256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013257 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 337191013258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191013259 cyclase homology domain; Region: CHD; cd07302 337191013260 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 337191013261 nucleotidyl binding site; other site 337191013262 metal binding site [ion binding]; metal-binding site 337191013263 dimer interface [polypeptide binding]; other site 337191013264 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 337191013265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191013266 Walker A/P-loop; other site 337191013267 ATP binding site [chemical binding]; other site 337191013268 Q-loop/lid; other site 337191013269 ABC transporter signature motif; other site 337191013270 Walker B; other site 337191013271 D-loop; other site 337191013272 H-loop/switch region; other site 337191013273 TOBE domain; Region: TOBE; cl01440 337191013274 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 337191013275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191013276 dimer interface [polypeptide binding]; other site 337191013277 conserved gate region; other site 337191013278 putative PBP binding loops; other site 337191013279 ABC-ATPase subunit interface; other site 337191013280 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 337191013281 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 337191013282 DNA binding residues [nucleotide binding] 337191013283 TOBE domain; Region: TOBE; cl01440 337191013284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191013285 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 337191013286 Walker A/P-loop; other site 337191013287 ATP binding site [chemical binding]; other site 337191013288 Q-loop/lid; other site 337191013289 ABC transporter signature motif; other site 337191013290 Walker B; other site 337191013291 D-loop; other site 337191013292 H-loop/switch region; other site 337191013293 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 337191013294 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 337191013295 MarR family; Region: MarR_2; pfam12802 337191013296 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 337191013297 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 337191013298 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 337191013299 RNA polymerase factor sigma-70; Validated; Region: PRK08241 337191013300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191013301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191013302 DNA binding residues [nucleotide binding] 337191013303 SnoaL-like domain; Region: SnoaL_4; pfam13577 337191013304 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 337191013305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 337191013306 catalytic core [active] 337191013307 short chain dehydrogenase; Provisional; Region: PRK07454 337191013308 classical (c) SDRs; Region: SDR_c; cd05233 337191013309 NAD(P) binding site [chemical binding]; other site 337191013310 active site 337191013311 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 337191013312 Phosphotransferase enzyme family; Region: APH; pfam01636 337191013313 putative active site [active] 337191013314 putative substrate binding site [chemical binding]; other site 337191013315 ATP binding site [chemical binding]; other site 337191013316 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191013317 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 337191013318 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191013319 active site 337191013320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013323 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 337191013324 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 337191013325 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 337191013326 phosphate binding site [ion binding]; other site 337191013327 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 337191013328 substrate binding pocket [chemical binding]; other site 337191013329 chain length determination region; other site 337191013330 substrate-Mg2+ binding site; other site 337191013331 catalytic residues [active] 337191013332 aspartate-rich region 1; other site 337191013333 active site lid residues [active] 337191013334 aspartate-rich region 2; other site 337191013335 Protein of unknown function (DUF422); Region: DUF422; cl00991 337191013336 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 337191013337 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 337191013338 active site 337191013339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191013340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013341 phytoene desaturase; Region: crtI_fam; TIGR02734 337191013342 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191013343 dimerization interface [polypeptide binding]; other site 337191013344 putative DNA binding site [nucleotide binding]; other site 337191013345 putative Zn2+ binding site [ion binding]; other site 337191013346 arsenical-resistance protein; Region: acr3; TIGR00832 337191013347 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 337191013348 active site 337191013349 Low molecular weight phosphatase family; Region: LMWPc; cd00115 337191013350 active site 337191013351 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 337191013352 Ion channel; Region: Ion_trans_2; pfam07885 337191013353 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 337191013354 TrkA-N domain; Region: TrkA_N; pfam02254 337191013355 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191013356 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191013357 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 337191013358 nucleophilic elbow; other site 337191013359 catalytic triad; other site 337191013360 hypothetical protein; Provisional; Region: PRK06126 337191013361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013362 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 337191013363 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 337191013364 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 337191013365 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 337191013366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 337191013367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191013368 dimer interface [polypeptide binding]; other site 337191013369 conserved gate region; other site 337191013370 putative PBP binding loops; other site 337191013371 ABC-ATPase subunit interface; other site 337191013372 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 337191013373 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 337191013374 Walker A/P-loop; other site 337191013375 ATP binding site [chemical binding]; other site 337191013376 Q-loop/lid; other site 337191013377 ABC transporter signature motif; other site 337191013378 Walker B; other site 337191013379 D-loop; other site 337191013380 H-loop/switch region; other site 337191013381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013382 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 337191013383 short chain dehydrogenase; Provisional; Region: PRK08263 337191013384 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 337191013385 NADP binding site [chemical binding]; other site 337191013386 active site 337191013387 steroid binding site; other site 337191013388 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 337191013389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013391 short chain dehydrogenase; Provisional; Region: PRK06179 337191013392 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 337191013393 NADP binding site [chemical binding]; other site 337191013394 active site 337191013395 steroid binding site; other site 337191013396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191013397 putative substrate translocation pore; other site 337191013398 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 337191013399 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 337191013400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191013401 phytoene desaturase; Region: crtI_fam; TIGR02734 337191013402 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 337191013403 substrate binding pocket [chemical binding]; other site 337191013404 substrate-Mg2+ binding site; other site 337191013405 aspartate-rich region 1; other site 337191013406 aspartate-rich region 2; other site 337191013407 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 337191013408 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 337191013409 active site 337191013410 metal binding site [ion binding]; metal-binding site 337191013411 nudix motif; other site 337191013412 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 337191013413 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 337191013414 Lysine efflux permease [General function prediction only]; Region: COG1279 337191013415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013417 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 337191013418 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 337191013419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191013420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 337191013421 dimerization interface [polypeptide binding]; other site 337191013422 H+ Antiporter protein; Region: 2A0121; TIGR00900 337191013423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191013424 putative substrate translocation pore; other site 337191013425 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 337191013426 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 337191013427 putative DNA binding site [nucleotide binding]; other site 337191013428 putative homodimer interface [polypeptide binding]; other site 337191013429 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 337191013430 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 337191013431 nucleotide binding site [chemical binding]; other site 337191013432 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 337191013433 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 337191013434 active site 337191013435 DNA binding site [nucleotide binding] 337191013436 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 337191013437 DNA binding site [nucleotide binding] 337191013438 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 337191013439 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191013440 short chain dehydrogenase; Provisional; Region: PRK07326 337191013441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191013442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191013443 putative substrate translocation pore; other site 337191013444 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191013445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191013446 putative Zn2+ binding site [ion binding]; other site 337191013447 putative DNA binding site [nucleotide binding]; other site 337191013448 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 337191013449 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 337191013450 active site 337191013451 metal binding site [ion binding]; metal-binding site 337191013452 hexamer interface [polypeptide binding]; other site 337191013453 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 337191013454 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 337191013455 Sulfate transporter family; Region: Sulfate_transp; pfam00916 337191013456 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 337191013457 active site clefts [active] 337191013458 zinc binding site [ion binding]; other site 337191013459 dimer interface [polypeptide binding]; other site 337191013460 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 337191013461 putative active site [active] 337191013462 DoxX-like family; Region: DoxX_2; pfam13564 337191013463 Domain of unknown function (DUF222); Region: DUF222; pfam02720 337191013464 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191013465 active site 337191013466 Domain of unknown function (DUF385); Region: DUF385; cl04387 337191013467 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 337191013468 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 337191013469 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 337191013470 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 337191013471 ligand binding site [chemical binding]; other site 337191013472 homodimer interface [polypeptide binding]; other site 337191013473 NAD(P) binding site [chemical binding]; other site 337191013474 trimer interface B [polypeptide binding]; other site 337191013475 trimer interface A [polypeptide binding]; other site 337191013476 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 337191013477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013478 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 337191013479 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 337191013480 active site 337191013481 catalytic tetrad [active] 337191013482 short chain dehydrogenase; Provisional; Region: PRK06500 337191013483 classical (c) SDRs; Region: SDR_c; cd05233 337191013484 NAD(P) binding site [chemical binding]; other site 337191013485 active site 337191013486 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 337191013487 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 337191013488 Moco binding site; other site 337191013489 metal coordination site [ion binding]; other site 337191013490 hypothetical protein; Validated; Region: PRK07121 337191013491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013492 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 337191013493 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 337191013494 metal-binding site [ion binding] 337191013495 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 337191013496 Soluble P-type ATPase [General function prediction only]; Region: COG4087 337191013497 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 337191013498 metal-binding site [ion binding] 337191013499 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 337191013500 putative homodimer interface [polypeptide binding]; other site 337191013501 putative homotetramer interface [polypeptide binding]; other site 337191013502 putative allosteric switch controlling residues; other site 337191013503 putative metal binding site [ion binding]; other site 337191013504 putative homodimer-homodimer interface [polypeptide binding]; other site 337191013505 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 337191013506 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191013507 L-aspartate oxidase; Provisional; Region: PRK07804 337191013508 L-aspartate oxidase; Provisional; Region: PRK06175 337191013509 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 337191013510 FAD dependent oxidoreductase; Region: DAO; pfam01266 337191013511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013512 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 337191013513 iron-sulfur cluster [ion binding]; other site 337191013514 [2Fe-2S] cluster binding site [ion binding]; other site 337191013515 classical (c) SDRs; Region: SDR_c; cd05233 337191013516 short chain dehydrogenase; Region: adh_short; pfam00106 337191013517 NAD(P) binding site [chemical binding]; other site 337191013518 active site 337191013519 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 337191013520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191013521 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 337191013522 hydrophobic ligand binding site; other site 337191013523 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 337191013524 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 337191013525 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 337191013526 putative NAD(P) binding site [chemical binding]; other site 337191013527 putative substrate binding site [chemical binding]; other site 337191013528 catalytic Zn binding site [ion binding]; other site 337191013529 structural Zn binding site [ion binding]; other site 337191013530 dimer interface [polypeptide binding]; other site 337191013531 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 337191013532 active site 337191013533 ATP binding site [chemical binding]; other site 337191013534 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 337191013535 Predicted esterase [General function prediction only]; Region: COG0627 337191013536 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 337191013537 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 337191013538 Predicted oxidoreductase [General function prediction only]; Region: COG3573 337191013539 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 337191013540 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 337191013541 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 337191013542 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191013543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191013544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191013545 Walker A/P-loop; other site 337191013546 ATP binding site [chemical binding]; other site 337191013547 Q-loop/lid; other site 337191013548 ABC transporter signature motif; other site 337191013549 Walker B; other site 337191013550 D-loop; other site 337191013551 H-loop/switch region; other site 337191013552 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 337191013553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 337191013554 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 337191013555 Walker A/P-loop; other site 337191013556 ATP binding site [chemical binding]; other site 337191013557 Q-loop/lid; other site 337191013558 ABC transporter signature motif; other site 337191013559 Walker B; other site 337191013560 D-loop; other site 337191013561 H-loop/switch region; other site 337191013562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 337191013563 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 337191013564 short chain dehydrogenase; Provisional; Region: PRK07814 337191013565 classical (c) SDRs; Region: SDR_c; cd05233 337191013566 NAD(P) binding site [chemical binding]; other site 337191013567 active site 337191013568 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 337191013569 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 337191013570 putative ligand binding site [chemical binding]; other site 337191013571 putative NAD binding site [chemical binding]; other site 337191013572 catalytic site [active] 337191013573 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 337191013574 RNA/DNA hybrid binding site [nucleotide binding]; other site 337191013575 active site 337191013576 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 337191013577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191013578 S-adenosylmethionine binding site [chemical binding]; other site 337191013579 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 337191013580 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 337191013581 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191013582 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 337191013583 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 337191013584 active site 337191013585 Phosphotransferase enzyme family; Region: APH; pfam01636 337191013586 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 337191013587 putative active site [active] 337191013588 putative substrate binding site [chemical binding]; other site 337191013589 ATP binding site [chemical binding]; other site 337191013590 SnoaL-like domain; Region: SnoaL_2; pfam12680 337191013591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 337191013592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 337191013593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 337191013594 dimerization interface [polypeptide binding]; other site 337191013595 MOSC domain; Region: MOSC; pfam03473 337191013596 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 337191013597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013599 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 337191013600 putative active site [active] 337191013601 putative substrate binding site [chemical binding]; other site 337191013602 ATP binding site [chemical binding]; other site 337191013603 Phosphotransferase enzyme family; Region: APH; pfam01636 337191013604 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 337191013605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191013606 active site 337191013607 phosphorylation site [posttranslational modification] 337191013608 intermolecular recognition site; other site 337191013609 dimerization interface [polypeptide binding]; other site 337191013610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 337191013611 DNA binding site [nucleotide binding] 337191013612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 337191013613 dimerization interface [polypeptide binding]; other site 337191013614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 337191013615 dimer interface [polypeptide binding]; other site 337191013616 phosphorylation site [posttranslational modification] 337191013617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191013618 ATP binding site [chemical binding]; other site 337191013619 Mg2+ binding site [ion binding]; other site 337191013620 G-X-G motif; other site 337191013621 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 337191013622 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 337191013623 intracellular protease, PfpI family; Region: PfpI; TIGR01382 337191013624 proposed catalytic triad [active] 337191013625 conserved cys residue [active] 337191013626 TIGR03086 family protein; Region: TIGR03086 337191013627 Predicted membrane protein [Function unknown]; Region: COG1297 337191013628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013630 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 337191013631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191013632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013633 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 337191013634 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 337191013635 classical (c) SDRs; Region: SDR_c; cd05233 337191013636 NAD(P) binding site [chemical binding]; other site 337191013637 active site 337191013638 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191013639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 337191013640 dimerization interface [polypeptide binding]; other site 337191013641 putative Zn2+ binding site [ion binding]; other site 337191013642 putative DNA binding site [nucleotide binding]; other site 337191013643 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 337191013644 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 337191013645 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 337191013646 tetramer interface [polypeptide binding]; other site 337191013647 heme binding pocket [chemical binding]; other site 337191013648 NADPH binding site [chemical binding]; other site 337191013649 competence damage-inducible protein A; Provisional; Region: PRK00549 337191013650 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 337191013651 putative MPT binding site; other site 337191013652 Competence-damaged protein; Region: CinA; pfam02464 337191013653 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 337191013654 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 337191013655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191013656 S-adenosylmethionine binding site [chemical binding]; other site 337191013657 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 337191013658 AAA domain; Region: AAA_17; cl19128 337191013659 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 337191013660 active site 337191013661 metal binding site [ion binding]; metal-binding site 337191013662 acyl-CoA synthetase; Validated; Region: PRK07788 337191013663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191013664 acyl-activating enzyme (AAE) consensus motif; other site 337191013665 AMP binding site [chemical binding]; other site 337191013666 active site 337191013667 CoA binding site [chemical binding]; other site 337191013668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 337191013669 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 337191013670 Methyltransferase domain; Region: Methyltransf_31; pfam13847 337191013671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191013672 S-adenosylmethionine binding site [chemical binding]; other site 337191013673 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 337191013674 active site 337191013675 catalytic tetrad [active] 337191013676 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 337191013677 Catalytic domain of Protein Kinases; Region: PKc; cd00180 337191013678 active site 337191013679 ATP binding site [chemical binding]; other site 337191013680 substrate binding site [chemical binding]; other site 337191013681 activation loop (A-loop); other site 337191013682 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 337191013683 AAA ATPase domain; Region: AAA_16; pfam13191 337191013684 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 337191013685 DNA-binding site [nucleotide binding]; DNA binding site 337191013686 RNA-binding motif; other site 337191013687 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 337191013688 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 337191013689 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 337191013690 putative acyl-acceptor binding pocket; other site 337191013691 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 337191013692 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 337191013693 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 337191013694 putative acyl-acceptor binding pocket; other site 337191013695 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 337191013696 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 337191013697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 337191013698 Transcriptional regulators [Transcription]; Region: FadR; COG2186 337191013699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191013700 DNA-binding site [nucleotide binding]; DNA binding site 337191013701 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 337191013702 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 337191013703 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191013704 NAD(P) binding site [chemical binding]; other site 337191013705 Predicted membrane protein [Function unknown]; Region: COG1511 337191013706 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191013707 classical (c) SDRs; Region: SDR_c; cd05233 337191013708 NAD(P) binding site [chemical binding]; other site 337191013709 active site 337191013710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013711 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 337191013712 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 337191013713 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 337191013714 Walker A motif; other site 337191013715 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; cl19160 337191013716 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 337191013717 ATP binding site [chemical binding]; other site 337191013718 Walker B motif; other site 337191013719 DNA binding loops [nucleotide binding] 337191013720 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 337191013721 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 337191013722 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 337191013723 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 337191013724 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 337191013725 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 337191013726 dimer interface [polypeptide binding]; other site 337191013727 ssDNA binding site [nucleotide binding]; other site 337191013728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 337191013729 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 337191013730 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 337191013731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 337191013732 Predicted integral membrane protein [Function unknown]; Region: COG5650 337191013733 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 337191013734 Transglycosylase; Region: Transgly; pfam00912 337191013735 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 337191013736 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 337191013737 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 337191013738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013739 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 337191013740 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 337191013741 classical (c) SDRs; Region: SDR_c; cd05233 337191013742 NAD(P) binding site [chemical binding]; other site 337191013743 active site 337191013744 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 337191013745 putative metal binding site [ion binding]; other site 337191013746 hypothetical protein; Provisional; Region: PRK14013 337191013747 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 337191013748 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 337191013749 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 337191013750 RibD C-terminal domain; Region: RibD_C; cl17279 337191013751 C-C_Bond_Lyase of the TIM-Barrel fold; Region: C-C_Bond_Lyase; pfam15617 337191013752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 337191013753 active site 337191013754 TRSP domain C terminus to PRTase_2; Region: TRSP; pfam12500 337191013755 Phosphoribosyl transferase (PRTase); Region: PRTase_1; pfam11202 337191013756 PELOTA RNA binding domain; Region: PELOTA_1; pfam15608 337191013757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 337191013758 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 337191013759 active site 337191013760 phosphorylation site [posttranslational modification] 337191013761 intermolecular recognition site; other site 337191013762 dimerization interface [polypeptide binding]; other site 337191013763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 337191013764 DNA binding residues [nucleotide binding] 337191013765 dimerization interface [polypeptide binding]; other site 337191013766 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 337191013767 acyl-CoA synthetase; Validated; Region: PRK07787 337191013768 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 337191013769 acyl-activating enzyme (AAE) consensus motif; other site 337191013770 AMP binding site [chemical binding]; other site 337191013771 active site 337191013772 CoA binding site [chemical binding]; other site 337191013773 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191013774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191013775 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191013776 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 337191013777 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 337191013778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191013779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 337191013781 Coenzyme A binding pocket [chemical binding]; other site 337191013782 Protein of unknown function (DUF429); Region: DUF429; cl12046 337191013783 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 337191013784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191013785 catalytic residue [active] 337191013786 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 337191013787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 337191013788 active site 337191013789 phosphorylation site [posttranslational modification] 337191013790 intermolecular recognition site; other site 337191013791 dimerization interface [polypeptide binding]; other site 337191013792 Helix-turn-helix domain; Region: HTH_20; pfam12840 337191013793 putative DNA binding site [nucleotide binding]; other site 337191013794 putative Zn2+ binding site [ion binding]; other site 337191013795 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 337191013796 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 337191013797 PAS domain; Region: PAS; smart00091 337191013798 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 337191013799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 337191013800 ATP binding site [chemical binding]; other site 337191013801 Mg2+ binding site [ion binding]; other site 337191013802 G-X-G motif; other site 337191013803 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 337191013804 Citrate transporter; Region: CitMHS; pfam03600 337191013805 DNA polymerase IV; Validated; Region: PRK03858 337191013806 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 337191013807 active site 337191013808 DNA binding site [nucleotide binding] 337191013809 Predicted acyl esterases [General function prediction only]; Region: COG2936 337191013810 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 337191013811 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 337191013812 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 337191013813 substrate binding pocket [chemical binding]; other site 337191013814 catalytic triad [active] 337191013815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191013816 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191013817 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191013818 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191013819 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 337191013820 Helix-turn-helix domain; Region: HTH_31; pfam13560 337191013821 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 337191013822 classical (c) SDRs; Region: SDR_c; cd05233 337191013823 NAD(P) binding site [chemical binding]; other site 337191013824 active site 337191013825 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 337191013826 L-aspartate oxidase; Provisional; Region: PRK06175 337191013827 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 337191013828 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 337191013829 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 337191013830 Walker A/P-loop; other site 337191013831 ATP binding site [chemical binding]; other site 337191013832 Q-loop/lid; other site 337191013833 ABC transporter signature motif; other site 337191013834 Walker B; other site 337191013835 D-loop; other site 337191013836 H-loop/switch region; other site 337191013837 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 337191013838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 337191013839 dimer interface [polypeptide binding]; other site 337191013840 conserved gate region; other site 337191013841 putative PBP binding loops; other site 337191013842 ABC-ATPase subunit interface; other site 337191013843 NMT1-like family; Region: NMT1_2; cl17432 337191013844 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 337191013845 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 337191013846 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 337191013847 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 337191013848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191013849 DNA-binding site [nucleotide binding]; DNA binding site 337191013850 UTRA domain; Region: UTRA; pfam07702 337191013851 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 337191013852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191013853 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 337191013854 Helix-turn-helix domain; Region: HTH_18; pfam12833 337191013855 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191013856 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 337191013857 NAD(P) binding site [chemical binding]; other site 337191013858 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191013859 Probable pheophorbidase; Region: PLN02965; cl17657 337191013860 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 337191013861 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191013862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191013863 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 337191013864 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 337191013865 NAD(P) binding site [chemical binding]; other site 337191013866 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 337191013867 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 337191013868 molybdopterin cofactor binding site; other site 337191013869 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 337191013870 molybdopterin cofactor binding site; other site 337191013871 Ferredoxin [Energy production and conversion]; Region: COG1146 337191013872 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 337191013873 ferredoxin-NADP+ reductase; Region: PLN02852 337191013874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 337191013875 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 337191013876 dimanganese center [ion binding]; other site 337191013877 PGAP1-like protein; Region: PGAP1; pfam07819 337191013878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191013879 S-adenosylmethionine binding site [chemical binding]; other site 337191013880 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 337191013881 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 337191013882 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 337191013883 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 337191013884 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 337191013885 Transcriptional regulators [Transcription]; Region: MarR; COG1846 337191013886 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 337191013887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191013888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191013889 putative substrate translocation pore; other site 337191013890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191013891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191013892 non-specific DNA binding site [nucleotide binding]; other site 337191013893 salt bridge; other site 337191013894 sequence-specific DNA binding site [nucleotide binding]; other site 337191013895 Cupin domain; Region: Cupin_2; cl17218 337191013896 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 337191013897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191013898 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 337191013899 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 337191013900 active site 337191013901 FMN binding site [chemical binding]; other site 337191013902 substrate binding site [chemical binding]; other site 337191013903 3Fe-4S cluster binding site [ion binding]; other site 337191013904 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 337191013905 domain_subunit interface; other site 337191013906 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 337191013907 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 337191013908 active site 337191013909 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 337191013910 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 337191013911 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 337191013912 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 337191013913 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 337191013914 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191013915 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 337191013916 FMN-binding pocket [chemical binding]; other site 337191013917 flavin binding motif; other site 337191013918 phosphate binding motif [ion binding]; other site 337191013919 beta-alpha-beta structure motif; other site 337191013920 NAD binding pocket [chemical binding]; other site 337191013921 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191013922 catalytic loop [active] 337191013923 iron binding site [ion binding]; other site 337191013924 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 337191013925 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 337191013926 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 337191013927 FMN-binding pocket [chemical binding]; other site 337191013928 flavin binding motif; other site 337191013929 phosphate binding motif [ion binding]; other site 337191013930 beta-alpha-beta structure motif; other site 337191013931 NAD binding pocket [chemical binding]; other site 337191013932 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191013933 catalytic loop [active] 337191013934 iron binding site [ion binding]; other site 337191013935 Cupin domain; Region: Cupin_2; cl17218 337191013936 Transcription factor WhiB; Region: Whib; pfam02467 337191013937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191013938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191013939 putative substrate translocation pore; other site 337191013940 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 337191013941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191013942 Uncharacterized conserved protein [Function unknown]; Region: COG5361 337191013943 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 337191013944 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 337191013945 Domain of unknown function (DUF202); Region: DUF202; cl09954 337191013946 Domain of unknown function (DUF202); Region: DUF202; cl09954 337191013947 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 337191013948 Uncharacterized conserved protein [Function unknown]; Region: COG5361 337191013949 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 337191013950 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 337191013951 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 337191013952 short chain dehydrogenase; Provisional; Region: PRK08219 337191013953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 337191013954 NAD(P) binding site [chemical binding]; other site 337191013955 active site 337191013956 Uncharacterized conserved protein [Function unknown]; Region: COG5361 337191013957 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 337191013958 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 337191013959 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 337191013960 Transposase, Mutator family; Region: Transposase_mut; cl19537 337191013961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 337191013962 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 337191013963 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 337191013964 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 337191013965 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 337191013966 MoxR-like ATPases [General function prediction only]; Region: COG0714 337191013967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191013968 Walker A motif; other site 337191013969 ATP binding site [chemical binding]; other site 337191013970 Walker B motif; other site 337191013971 arginine finger; other site 337191013972 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 337191013973 Protein of unknown function DUF58; Region: DUF58; pfam01882 337191013974 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 337191013975 homotrimer interaction site [polypeptide binding]; other site 337191013976 putative active site [active] 337191013977 Predicted transcriptional regulators [Transcription]; Region: COG1733 337191013978 aconitate hydratase; Provisional; Region: acnA; PRK12881 337191013979 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 337191013980 substrate binding site [chemical binding]; other site 337191013981 ligand binding site [chemical binding]; other site 337191013982 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 337191013983 substrate binding site [chemical binding]; other site 337191013984 Transcriptional regulators [Transcription]; Region: GntR; COG1802 337191013985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 337191013986 DNA-binding site [nucleotide binding]; DNA binding site 337191013987 FCD domain; Region: FCD; pfam07729 337191013988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 337191013989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191013990 Ligand Binding Site [chemical binding]; other site 337191013991 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 337191013992 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 337191013993 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 337191013994 Predicted membrane protein [Function unknown]; Region: COG4270 337191013995 Integral membrane protein DUF95; Region: DUF95; pfam01944 337191013996 RDD family; Region: RDD; pfam06271 337191013997 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 337191013998 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 337191013999 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 337191014000 metal binding site [ion binding]; metal-binding site 337191014001 putative dimer interface [polypeptide binding]; other site 337191014002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 337191014003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191014004 active site 337191014005 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 337191014006 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 337191014007 active site 337191014008 HIGH motif; other site 337191014009 nucleotide binding site [chemical binding]; other site 337191014010 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 337191014011 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 337191014012 active site 337191014013 KMSKS motif; other site 337191014014 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 337191014015 tRNA binding surface [nucleotide binding]; other site 337191014016 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 337191014017 SdpI/YhfL protein family; Region: SdpI; pfam13630 337191014018 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 337191014019 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 337191014020 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 337191014021 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 337191014022 cyclase homology domain; Region: CHD; cd07302 337191014023 nucleotidyl binding site; other site 337191014024 metal binding site [ion binding]; metal-binding site 337191014025 dimer interface [polypeptide binding]; other site 337191014026 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 337191014027 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 337191014028 hypothetical protein; Validated; Region: PRK00228 337191014029 H+ Antiporter protein; Region: 2A0121; TIGR00900 337191014030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 337191014031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 337191014032 catalytic residue [active] 337191014033 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 337191014034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191014035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191014036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191014037 diacylglycerol kinase; Reviewed; Region: PRK11914 337191014038 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 337191014039 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 337191014040 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 337191014041 active site 337191014042 NTP binding site [chemical binding]; other site 337191014043 metal binding triad [ion binding]; metal-binding site 337191014044 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 337191014045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 337191014046 Zn2+ binding site [ion binding]; other site 337191014047 Mg2+ binding site [ion binding]; other site 337191014048 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 337191014049 active site 337191014050 Ap6A binding site [chemical binding]; other site 337191014051 nudix motif; other site 337191014052 metal binding site [ion binding]; metal-binding site 337191014053 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 337191014054 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 337191014055 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 337191014056 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 337191014057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191014058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191014059 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 337191014060 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 337191014061 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 337191014062 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 337191014063 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 337191014064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191014065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191014066 DNA binding residues [nucleotide binding] 337191014067 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 337191014068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191014069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191014070 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 337191014071 catalytic residues [active] 337191014072 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 337191014073 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 337191014074 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 337191014075 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 337191014076 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 337191014077 active site 337191014078 metal binding site [ion binding]; metal-binding site 337191014079 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 337191014080 ParB-like nuclease domain; Region: ParBc; pfam02195 337191014081 KorB domain; Region: KorB; pfam08535 337191014082 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 337191014083 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 337191014084 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191014085 P-loop; other site 337191014086 Magnesium ion binding site [ion binding]; other site 337191014087 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 337191014088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191014089 S-adenosylmethionine binding site [chemical binding]; other site 337191014090 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 337191014091 G-X-X-G motif; other site 337191014092 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 337191014093 RxxxH motif; other site 337191014094 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 337191014095 Haemolytic domain; Region: Haemolytic; pfam01809 337191014096 Ribonuclease P; Region: Ribonuclease_P; cl00457 337191014097 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 337191014098 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 337191014099 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 337191014100 P-loop; other site 337191014101 Magnesium ion binding site [ion binding]; other site 337191014102 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 337191014103 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 337191014104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 337191014105 Walker A/P-loop; other site 337191014106 ATP binding site [chemical binding]; other site 337191014107 Q-loop/lid; other site 337191014108 Cadherin repeat-like domain; Region: CA_like; cl15786 337191014109 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 337191014110 Fic/DOC family; Region: Fic; cl00960 337191014111 Protein of unknown function DUF262; Region: DUF262; pfam03235 337191014112 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 337191014113 active site 337191014114 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 337191014115 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 337191014116 LGFP repeat; Region: LGFP; pfam08310 337191014117 LGFP repeat; Region: LGFP; pfam08310 337191014118 LGFP repeat; Region: LGFP; pfam08310 337191014119 ParB-like nuclease domain; Region: ParB; smart00470 337191014120 Transposase; Region: DEDD_Tnp_IS110; pfam01548 337191014121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191014122 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191014123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 337191014124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 337191014125 putative substrate translocation pore; other site 337191014126 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 337191014127 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 337191014128 Sulfate transporter family; Region: Sulfate_transp; pfam00916 337191014129 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 337191014130 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 337191014131 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 337191014132 DNA binding residues [nucleotide binding] 337191014133 CrcB-like protein; Region: CRCB; pfam02537 337191014134 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 337191014135 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 337191014136 Ligand Binding Site [chemical binding]; other site 337191014137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191014138 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191014139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191014140 dimerization interface [polypeptide binding]; other site 337191014141 putative DNA binding site [nucleotide binding]; other site 337191014142 putative Zn2+ binding site [ion binding]; other site 337191014143 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 337191014144 putative metal binding site [ion binding]; other site 337191014145 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 337191014146 active site 337191014147 Low molecular weight phosphatase family; Region: LMWPc; cd00115 337191014148 active site 337191014149 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 337191014150 active site 337191014151 arsenical-resistance protein; Region: acr3; TIGR00832 337191014152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 337191014153 dimerization interface [polypeptide binding]; other site 337191014154 putative DNA binding site [nucleotide binding]; other site 337191014155 putative Zn2+ binding site [ion binding]; other site 337191014156 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 337191014157 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 337191014158 catalytic residues [active] 337191014159 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 337191014160 Fic/DOC family; Region: Fic; cl00960 337191014161 SIR2-like domain; Region: SIR2_2; pfam13289 337191014162 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 337191014163 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 337191014164 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 337191014165 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 337191014166 Walker A motif; other site 337191014167 ATP binding site [chemical binding]; other site 337191014168 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 337191014169 Walker B motif; other site 337191014170 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 337191014171 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 337191014172 Peptidase family M23; Region: Peptidase_M23; pfam01551 337191014173 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 337191014174 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 337191014175 N-acetyl-D-glucosamine binding site [chemical binding]; other site 337191014176 catalytic residue [active] 337191014177 AAA-like domain; Region: AAA_10; pfam12846 337191014178 Transcriptional regulator; Region: Transcrip_reg; cl00361 337191014179 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 337191014180 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 337191014181 Cutinase; Region: Cutinase; pfam01083 337191014182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191014183 non-specific DNA binding site [nucleotide binding]; other site 337191014184 salt bridge; other site 337191014185 sequence-specific DNA binding site [nucleotide binding]; other site 337191014186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191014187 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191014188 non-specific DNA binding site [nucleotide binding]; other site 337191014189 salt bridge; other site 337191014190 sequence-specific DNA binding site [nucleotide binding]; other site 337191014191 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 337191014192 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 337191014193 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 337191014194 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 337191014195 P-loop; other site 337191014196 Magnesium ion binding site [ion binding]; other site 337191014197 Cutinase; Region: Cutinase; pfam01083 337191014198 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; pfam05433 337191014199 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 337191014200 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Region: AceE; COG2609 337191014201 AAA-like domain; Region: AAA_10; pfam12846 337191014202 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 337191014203 Peptidase family M23; Region: Peptidase_M23; pfam01551 337191014204 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 337191014205 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 337191014206 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 337191014207 N-acetyl-D-glucosamine binding site [chemical binding]; other site 337191014208 catalytic residue [active] 337191014209 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 337191014210 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 337191014211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 337191014212 S-adenosylmethionine binding site [chemical binding]; other site 337191014213 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 337191014214 DEAD-like helicases superfamily; Region: DEXDc; smart00487 337191014215 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 337191014216 helicase superfamily c-terminal domain; Region: HELICc; smart00490 337191014217 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 337191014218 Integrase core domain; Region: rve; pfam00665 337191014219 Abi-like protein; Region: Abi_2; cl01988 337191014220 TrwC relaxase; Region: TrwC; pfam08751 337191014221 AAA domain; Region: AAA_30; pfam13604 337191014222 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 337191014223 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 337191014224 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 337191014225 Catalytic site; other site 337191014226 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 337191014227 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 337191014228 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 337191014229 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 337191014230 catalytic residues [active] 337191014231 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191014232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191014233 non-specific DNA binding site [nucleotide binding]; other site 337191014234 salt bridge; other site 337191014235 sequence-specific DNA binding site [nucleotide binding]; other site 337191014236 Nuclease-related domain; Region: NERD; pfam08378 337191014237 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 337191014238 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191014239 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 337191014240 cofactor binding site; other site 337191014241 DNA binding site [nucleotide binding] 337191014242 substrate interaction site [chemical binding]; other site 337191014243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191014244 non-specific DNA binding site [nucleotide binding]; other site 337191014245 salt bridge; other site 337191014246 sequence-specific DNA binding site [nucleotide binding]; other site 337191014247 Microtubule associated protein (MAP65/ASE1 family); Region: MAP65_ASE1; pfam03999 337191014248 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191014249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191014250 non-specific DNA binding site [nucleotide binding]; other site 337191014251 salt bridge; other site 337191014252 sequence-specific DNA binding site [nucleotide binding]; other site 337191014253 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 337191014254 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 337191014255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 337191014256 non-specific DNA binding site [nucleotide binding]; other site 337191014257 salt bridge; other site 337191014258 sequence-specific DNA binding site [nucleotide binding]; other site 337191014259 AAA domain; Region: AAA_23; pfam13476 337191014260 Walker A/P-loop; other site 337191014261 Walker A/P-loop; other site 337191014262 ATP binding site [chemical binding]; other site 337191014263 ATP binding site [chemical binding]; other site 337191014264 Q-loop/lid; other site 337191014265 ATP binding site [chemical binding]; other site 337191014266 Q-loop/lid; other site 337191014267 AAA domain; Region: AAA_21; pfam13304 337191014268 Walker B; other site 337191014269 D-loop; other site 337191014270 H-loop/switch region; other site 337191014271 Bacterial PH domain; Region: bPH_3; pfam14470 337191014272 Short C-terminal domain; Region: SHOCT; pfam09851 337191014273 Transposase, Mutator family; Region: Transposase_mut; cl19537 337191014274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 337191014275 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 337191014276 hypothetical protein; Provisional; Region: PRK10236 337191014277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl18948 337191014278 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 337191014279 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014280 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 337191014281 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014282 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014283 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014284 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 337191014285 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014286 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014287 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014288 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014289 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 337191014290 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014291 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 337191014292 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 337191014293 Transposase; Region: HTH_Tnp_1; cl17663 337191014294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 337191014295 putative transposase OrfB; Reviewed; Region: PHA02517 337191014296 HTH-like domain; Region: HTH_21; pfam13276 337191014297 Integrase core domain; Region: rve; pfam00665 337191014298 Integrase core domain; Region: rve_3; pfam13683 337191014299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 337191014300 active site 337191014301 MMPL family; Region: MMPL; cl14618 337191014302 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191014303 CoenzymeA binding site [chemical binding]; other site 337191014304 subunit interaction site [polypeptide binding]; other site 337191014305 PHB binding site; other site 337191014306 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 337191014307 Helix-turn-helix domain; Region: HTH_18; pfam12833 337191014308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 337191014309 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191014310 catalytic loop [active] 337191014311 iron binding site [ion binding]; other site 337191014312 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 337191014313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 337191014314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 337191014315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 337191014316 Reductase C-terminal; Region: Reductase_C; pfam14759 337191014317 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 337191014318 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 337191014319 NlpC/p60-like transpeptidase; Region: Transpep_BrtH; pfam14399 337191014320 putative active site [active] 337191014321 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 337191014322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 337191014323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 337191014324 Transposase, Mutator family; Region: Transposase_mut; cl19537 337191014325 Integrase core domain; Region: rve_3; cl15866 337191014326 HTH-like domain; Region: HTH_21; pfam13276 337191014327 Integrase core domain; Region: rve; pfam00665 337191014328 Transposase; Region: HTH_Tnp_1; cl17663 337191014329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 337191014330 Transport protein; Region: actII; TIGR00833 337191014331 MMPL family; Region: MMPL; pfam03176 337191014332 MMPL family; Region: MMPL; pfam03176 337191014333 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 337191014334 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 337191014335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 337191014336 short chain dehydrogenase; Provisional; Region: PRK06181 337191014337 classical (c) SDRs; Region: SDR_c; cd05233 337191014338 NAD(P) binding site [chemical binding]; other site 337191014339 active site 337191014340 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 337191014341 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 337191014342 FAD binding pocket [chemical binding]; other site 337191014343 FAD binding motif [chemical binding]; other site 337191014344 phosphate binding motif [ion binding]; other site 337191014345 beta-alpha-beta structure motif; other site 337191014346 NAD(p) ribose binding residues [chemical binding]; other site 337191014347 NAD binding pocket [chemical binding]; other site 337191014348 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 337191014349 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 337191014350 catalytic loop [active] 337191014351 iron binding site [ion binding]; other site 337191014352 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 337191014353 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191014354 Putative lysophospholipase; Region: Hydrolase_4; cl19140 337191014355 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 337191014356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191014357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191014358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 337191014359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 337191014360 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 337191014361 MMPL family; Region: MMPL; pfam03176 337191014362 MMPL family; Region: MMPL; cl14618 337191014363 Transposase, Mutator family; Region: Transposase_mut; cl19537 337191014364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 337191014365 transposase; Provisional; Region: PRK06526 337191014366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 337191014367 Walker A motif; other site 337191014368 ATP binding site [chemical binding]; other site 337191014369 Walker B motif; other site 337191014370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 337191014371 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 337191014372 DNA-binding interface [nucleotide binding]; DNA binding site 337191014373 Integrase core domain; Region: rve; pfam00665 337191014374 Transposase; Region: HTH_Tnp_1; cl17663 337191014375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 337191014376 HTH-like domain; Region: HTH_21; pfam13276 337191014377 Integrase core domain; Region: rve; pfam00665 337191014378 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 337191014379 Helix-turn-helix domain; Region: HTH_38; pfam13936 337191014380 Integrase core domain; Region: rve; pfam00665 337191014381 Integrase core domain; Region: rve_3; cl15866 337191014382 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 337191014383 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 337191014384 dimer interface [polypeptide binding]; other site 337191014385 acyl-activating enzyme (AAE) consensus motif; other site 337191014386 putative active site [active] 337191014387 AMP binding site [chemical binding]; other site 337191014388 putative CoA binding site [chemical binding]; other site 337191014389 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191014390 mce related protein; Region: MCE; pfam02470 337191014391 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191014392 mce related protein; Region: MCE; pfam02470 337191014393 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191014394 mce related protein; Region: MCE; pfam02470 337191014395 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191014396 mce related protein; Region: MCE; pfam02470 337191014397 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 337191014398 mce related protein; Region: MCE; pfam02470 337191014399 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 337191014400 mce related protein; Region: MCE; pfam02470 337191014401 Permease; Region: Permease; pfam02405 337191014402 Permease; Region: Permease; pfam02405 337191014403 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 337191014404 CoenzymeA binding site [chemical binding]; other site 337191014405 subunit interaction site [polypeptide binding]; other site 337191014406 PHB binding site; other site 337191014407 Transposase; Region: HTH_Tnp_1; cl17663 337191014408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 337191014409 putative transposase OrfB; Reviewed; Region: PHA02517 337191014410 HTH-like domain; Region: HTH_21; pfam13276 337191014411 Integrase core domain; Region: rve; pfam00665 337191014412 Integrase core domain; Region: rve_3; pfam13683 337191014413 Helicase associated domain; Region: HA; pfam03457 337191014414 Helicase associated domain; Region: HA; pfam03457 337191014415 Helicase associated domain; Region: HA; pfam03457 337191014416 Helicase associated domain; Region: HA; pfam03457 337191014417 Helicase associated domain; Region: HA; pfam03457 337191014418 Helicase associated domain; Region: HA; pfam03457 337191014419 Helicase associated domain; Region: HA; pfam03457 337191014420 Helicase associated domain; Region: HA; pfam03457 337191014421 Helicase associated domain; Region: HA; pfam03457 337191014422 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 337191014423 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 337191014424 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 337191014425 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 337191014426 active site 337191014427 DNA binding site [nucleotide binding] 337191014428 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 337191014429 DNA binding site [nucleotide binding] 337191014430 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 337191014431 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191014432 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 337191014433 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; cl19880 337191014434 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 337191014435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 337191014436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 337191014437 DNA binding residues [nucleotide binding] 337191014438 MspA; Region: MspA; pfam09203 337191014439 MspA; Region: MspA; pfam09203 337191014440 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 337191014441 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 337191014442 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 337191014443 nucleotide binding site [chemical binding]; other site 337191014444 putative NEF/HSP70 interaction site [polypeptide binding]; other site 337191014445 SBD interface [polypeptide binding]; other site 337191014446 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 337191014447 G1 box; other site 337191014448 GTP/Mg2+ binding site [chemical binding]; other site 337191014449 G2 box; other site 337191014450 Switch I region; other site 337191014451 G3 box; other site 337191014452 Switch II region; other site 337191014453 G4 box; other site 337191014454 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 337191014455 G1 box; other site 337191014456 GTP/Mg2+ binding site [chemical binding]; other site 337191014457 G2 box; other site 337191014458 Switch I region; other site 337191014459 G3 box; other site 337191014460 Switch II region; other site 337191014461 G4 box; other site 337191014462 G5 box; other site 337191014463 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 337191014464 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525 337191014465 nucleotide binding site [chemical binding]; other site 337191014466 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320