-- dump date   	20140619_103555
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
526226000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
526226000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
526226000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226000004	Walker A motif; other site
526226000005	ATP binding site [chemical binding]; other site
526226000006	Walker B motif; other site
526226000007	arginine finger; other site
526226000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
526226000009	DnaA box-binding interface [nucleotide binding]; other site
526226000010	DNA polymerase III subunit beta; Validated; Region: PRK07761
526226000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
526226000012	putative DNA binding surface [nucleotide binding]; other site
526226000013	dimer interface [polypeptide binding]; other site
526226000014	beta-clamp/clamp loader binding surface; other site
526226000015	beta-clamp/translesion DNA polymerase binding surface; other site
526226000016	recombination protein F; Reviewed; Region: recF; PRK00064
526226000017	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
526226000018	Walker A/P-loop; other site
526226000019	ATP binding site [chemical binding]; other site
526226000020	Q-loop/lid; other site
526226000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226000022	ABC transporter signature motif; other site
526226000023	Walker B; other site
526226000024	D-loop; other site
526226000025	H-loop/switch region; other site
526226000026	hypothetical protein; Provisional; Region: PRK03195
526226000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
526226000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226000029	ATP binding site [chemical binding]; other site
526226000030	Mg2+ binding site [ion binding]; other site
526226000031	G-X-G motif; other site
526226000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
526226000033	anchoring element; other site
526226000034	dimer interface [polypeptide binding]; other site
526226000035	ATP binding site [chemical binding]; other site
526226000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
526226000037	active site
526226000038	putative metal-binding site [ion binding]; other site
526226000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
526226000040	DNA gyrase subunit A; Validated; Region: PRK05560
526226000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
526226000042	CAP-like domain; other site
526226000043	active site
526226000044	primary dimer interface [polypeptide binding]; other site
526226000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526226000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526226000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526226000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526226000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526226000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
526226000051	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
526226000052	Winged helix-turn helix; Region: HTH_29; pfam13551
526226000053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
526226000054	Integrase core domain; Region: rve; pfam00665
526226000055	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
526226000056	Transposase; Region: DDE_Tnp_ISL3; pfam01610
526226000057	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
526226000058	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
526226000059	active site
526226000060	Rhomboid family; Region: Rhomboid; pfam01694
526226000061	putative septation inhibitor protein; Reviewed; Region: PRK00159
526226000062	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
526226000063	Glutamine amidotransferase class-I; Region: GATase; pfam00117
526226000064	glutamine binding [chemical binding]; other site
526226000065	catalytic triad [active]
526226000066	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526226000067	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226000068	active site
526226000069	ATP binding site [chemical binding]; other site
526226000070	substrate binding site [chemical binding]; other site
526226000071	activation loop (A-loop); other site
526226000072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
526226000073	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526226000074	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526226000075	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526226000076	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
526226000077	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526226000078	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226000079	active site
526226000080	ATP binding site [chemical binding]; other site
526226000081	substrate binding site [chemical binding]; other site
526226000082	activation loop (A-loop); other site
526226000083	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
526226000084	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
526226000085	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
526226000086	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
526226000087	Protein phosphatase 2C; Region: PP2C; pfam00481
526226000088	active site
526226000089	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526226000090	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526226000091	phosphopeptide binding site; other site
526226000092	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
526226000093	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526226000094	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526226000095	phosphopeptide binding site; other site
526226000096	Abortive infection C-terminus; Region: Abi_C; pfam14355
526226000097	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
526226000098	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
526226000099	PLD-like domain; Region: PLDc_2; pfam13091
526226000100	putative homodimer interface [polypeptide binding]; other site
526226000101	putative active site [active]
526226000102	catalytic site [active]
526226000103	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526226000104	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226000105	ATP binding site [chemical binding]; other site
526226000106	putative Mg++ binding site [ion binding]; other site
526226000107	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226000108	ATP-binding site [chemical binding]; other site
526226000109	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
526226000110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
526226000111	Transposase; Region: DDE_Tnp_ISL3; pfam01610
526226000112	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
526226000113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
526226000114	Nitronate monooxygenase; Region: NMO; pfam03060
526226000115	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
526226000116	FMN binding site [chemical binding]; other site
526226000117	substrate binding site [chemical binding]; other site
526226000118	putative catalytic residue [active]
526226000119	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526226000120	Beta-lactamase; Region: Beta-lactamase; pfam00144
526226000121	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
526226000122	Domain of unknown function (DUF385); Region: DUF385; pfam04075
526226000123	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
526226000124	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226000125	acyl-activating enzyme (AAE) consensus motif; other site
526226000126	AMP binding site [chemical binding]; other site
526226000127	active site
526226000128	CoA binding site [chemical binding]; other site
526226000129	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
526226000130	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226000131	acyl-activating enzyme (AAE) consensus motif; other site
526226000132	AMP binding site [chemical binding]; other site
526226000133	active site
526226000134	CoA binding site [chemical binding]; other site
526226000135	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
526226000136	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
526226000137	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526226000138	Walker A/P-loop; other site
526226000139	ATP binding site [chemical binding]; other site
526226000140	Q-loop/lid; other site
526226000141	ABC transporter signature motif; other site
526226000142	Walker B; other site
526226000143	D-loop; other site
526226000144	H-loop/switch region; other site
526226000145	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526226000146	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526226000147	Walker A/P-loop; other site
526226000148	ATP binding site [chemical binding]; other site
526226000149	Q-loop/lid; other site
526226000150	ABC transporter signature motif; other site
526226000151	Walker B; other site
526226000152	D-loop; other site
526226000153	H-loop/switch region; other site
526226000154	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
526226000155	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226000156	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226000157	active site
526226000158	Methyltransferase domain; Region: Methyltransf_23; pfam13489
526226000159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226000160	S-adenosylmethionine binding site [chemical binding]; other site
526226000161	classical (c) SDRs; Region: SDR_c; cd05233
526226000162	NAD(P) binding site [chemical binding]; other site
526226000163	active site
526226000164	RibD C-terminal domain; Region: RibD_C; cl17279
526226000165	AAA ATPase domain; Region: AAA_16; pfam13191
526226000166	AAA domain; Region: AAA_22; pfam13401
526226000167	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226000168	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226000169	DNA binding residues [nucleotide binding]
526226000170	dimerization interface [polypeptide binding]; other site
526226000171	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226000172	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226000173	cytoskeletal protein RodZ; Provisional; Region: PRK10856
526226000174	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226000175	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226000176	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
526226000177	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
526226000178	Fasciclin domain; Region: Fasciclin; pfam02469
526226000179	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
526226000180	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
526226000181	Moco binding site; other site
526226000182	metal coordination site [ion binding]; other site
526226000183	dimerization interface [polypeptide binding]; other site
526226000184	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
526226000185	glutaminase; Provisional; Region: PRK00971
526226000186	Protein of unknown function (DUF664); Region: DUF664; pfam04978
526226000187	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
526226000188	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
526226000189	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226000190	acyl-activating enzyme (AAE) consensus motif; other site
526226000191	AMP binding site [chemical binding]; other site
526226000192	active site
526226000193	CoA binding site [chemical binding]; other site
526226000194	GAF domain; Region: GAF; cl17456
526226000195	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226000196	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226000197	DNA binding residues [nucleotide binding]
526226000198	dimerization interface [polypeptide binding]; other site
526226000199	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
526226000200	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
526226000201	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226000202	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226000203	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526226000204	Beta-lactamase; Region: Beta-lactamase; pfam00144
526226000205	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226000206	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226000207	DNA binding residues [nucleotide binding]
526226000208	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
526226000209	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
526226000210	NAD binding site [chemical binding]; other site
526226000211	catalytic Zn binding site [ion binding]; other site
526226000212	substrate binding site [chemical binding]; other site
526226000213	structural Zn binding site [ion binding]; other site
526226000214	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526226000215	Predicted membrane protein [Function unknown]; Region: COG2259
526226000216	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
526226000217	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
526226000218	Sulfate transporter family; Region: Sulfate_transp; pfam00916
526226000219	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
526226000220	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
526226000221	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
526226000222	active site
526226000223	DNA binding site [nucleotide binding]
526226000224	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
526226000225	DNA binding site [nucleotide binding]
526226000226	Anti-sigma-K factor rskA; Region: RskA; pfam10099
526226000227	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
526226000228	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226000229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226000230	DNA binding residues [nucleotide binding]
526226000231	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
526226000232	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
526226000233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226000234	S-adenosylmethionine binding site [chemical binding]; other site
526226000235	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
526226000236	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
526226000237	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226000238	hydroxyglutarate oxidase; Provisional; Region: PRK11728
526226000239	hypothetical protein; Provisional; Region: PRK11770
526226000240	Domain of unknown function (DUF307); Region: DUF307; pfam03733
526226000241	Domain of unknown function (DUF307); Region: DUF307; pfam03733
526226000242	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526226000243	TIGR03086 family protein; Region: TIGR03086
526226000244	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526226000245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226000246	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
526226000247	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
526226000248	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526226000249	NAD(P) binding site [chemical binding]; other site
526226000250	catalytic residues [active]
526226000251	Protein of unknown function (DUF779); Region: DUF779; pfam05610
526226000252	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
526226000253	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
526226000254	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
526226000255	active site
526226000256	TDP-binding site; other site
526226000257	acceptor substrate-binding pocket; other site
526226000258	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
526226000259	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
526226000260	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
526226000261	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
526226000262	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
526226000263	active site
526226000264	dimer interface [polypeptide binding]; other site
526226000265	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
526226000266	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
526226000267	active site
526226000268	FMN binding site [chemical binding]; other site
526226000269	substrate binding site [chemical binding]; other site
526226000270	3Fe-4S cluster binding site [ion binding]; other site
526226000271	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
526226000272	domain interface; other site
526226000273	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
526226000274	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226000275	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
526226000276	putative hydrophobic ligand binding site [chemical binding]; other site
526226000277	Cutinase; Region: Cutinase; pfam01083
526226000278	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526226000279	RNA binding surface [nucleotide binding]; other site
526226000280	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
526226000281	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
526226000282	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
526226000283	dimer interface [polypeptide binding]; other site
526226000284	putative anticodon binding site; other site
526226000285	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526226000286	motif 1; other site
526226000287	dimer interface [polypeptide binding]; other site
526226000288	active site
526226000289	motif 2; other site
526226000290	motif 3; other site
526226000291	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226000292	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
526226000293	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
526226000294	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
526226000295	NAD(P) binding site [chemical binding]; other site
526226000296	catalytic residues [active]
526226000297	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
526226000298	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
526226000299	putative active site [active]
526226000300	putative metal binding site [ion binding]; other site
526226000301	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
526226000302	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
526226000303	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
526226000304	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
526226000305	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
526226000306	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
526226000307	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
526226000308	Helix-turn-helix domain; Region: HTH_18; pfam12833
526226000309	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226000310	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226000311	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
526226000312	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
526226000313	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226000314	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226000315	NAD(P) binding site [chemical binding]; other site
526226000316	active site
526226000317	Predicted membrane protein [Function unknown]; Region: COG2119
526226000318	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
526226000319	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
526226000320	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526226000321	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
526226000322	Walker A/P-loop; other site
526226000323	ATP binding site [chemical binding]; other site
526226000324	Q-loop/lid; other site
526226000325	ABC transporter signature motif; other site
526226000326	Walker B; other site
526226000327	D-loop; other site
526226000328	H-loop/switch region; other site
526226000329	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526226000330	Walker A/P-loop; other site
526226000331	ATP binding site [chemical binding]; other site
526226000332	Q-loop/lid; other site
526226000333	ABC transporter signature motif; other site
526226000334	Walker B; other site
526226000335	D-loop; other site
526226000336	H-loop/switch region; other site
526226000337	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
526226000338	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
526226000339	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
526226000340	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
526226000341	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
526226000342	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
526226000343	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
526226000344	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
526226000345	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
526226000346	tandem repeat interface [polypeptide binding]; other site
526226000347	oligomer interface [polypeptide binding]; other site
526226000348	active site residues [active]
526226000349	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
526226000350	active site residue [active]
526226000351	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
526226000352	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
526226000353	putative active site [active]
526226000354	catalytic site [active]
526226000355	putative metal binding site [ion binding]; other site
526226000356	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
526226000357	Ferritin-like domain; Region: Ferritin; pfam00210
526226000358	ferroxidase diiron center [ion binding]; other site
526226000359	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
526226000360	CAAX protease self-immunity; Region: Abi; pfam02517
526226000361	prephenate dehydratase; Provisional; Region: PRK11898
526226000362	Prephenate dehydratase; Region: PDT; pfam00800
526226000363	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
526226000364	putative L-Phe binding site [chemical binding]; other site
526226000365	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226000366	catalytic core [active]
526226000367	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
526226000368	Septum formation; Region: Septum_form; pfam13845
526226000369	Septum formation; Region: Septum_form; pfam13845
526226000370	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
526226000371	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
526226000372	seryl-tRNA synthetase; Provisional; Region: PRK05431
526226000373	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
526226000374	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
526226000375	dimer interface [polypeptide binding]; other site
526226000376	active site
526226000377	motif 1; other site
526226000378	motif 2; other site
526226000379	motif 3; other site
526226000380	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226000381	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226000382	active site
526226000383	Histidine kinase; Region: HisKA_3; pfam07730
526226000384	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526226000385	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226000386	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226000387	DNA binding residues [nucleotide binding]
526226000388	dimerization interface [polypeptide binding]; other site
526226000389	Secretory lipase; Region: LIP; pfam03583
526226000390	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226000391	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226000392	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526226000393	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
526226000394	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
526226000395	iron-sulfur cluster [ion binding]; other site
526226000396	[2Fe-2S] cluster binding site [ion binding]; other site
526226000397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226000398	NAD(P) binding site [chemical binding]; other site
526226000399	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526226000400	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526226000401	putative acyl-acceptor binding pocket; other site
526226000402	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526226000403	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526226000404	putative acyl-acceptor binding pocket; other site
526226000405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226000406	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526226000407	active site
526226000408	motif I; other site
526226000409	motif II; other site
526226000410	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
526226000411	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
526226000412	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
526226000413	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
526226000414	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
526226000415	amidase catalytic site [active]
526226000416	Zn binding residues [ion binding]; other site
526226000417	substrate binding site [chemical binding]; other site
526226000418	Stage II sporulation protein; Region: SpoIID; pfam08486
526226000419	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
526226000420	LGFP repeat; Region: LGFP; pfam08310
526226000421	GAF domain; Region: GAF; cl17456
526226000422	ANTAR domain; Region: ANTAR; pfam03861
526226000423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226000424	S-adenosylmethionine binding site [chemical binding]; other site
526226000425	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
526226000426	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226000427	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226000428	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526226000429	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
526226000430	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226000431	UDP-galactopyranose mutase; Region: GLF; pfam03275
526226000432	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526226000433	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526226000434	active site
526226000435	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526226000436	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
526226000437	Predicted esterase [General function prediction only]; Region: COG0627
526226000438	Putative esterase; Region: Esterase; pfam00756
526226000439	LGFP repeat; Region: LGFP; pfam08310
526226000440	Cutinase; Region: Cutinase; pfam01083
526226000441	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
526226000442	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226000443	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
526226000444	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
526226000445	acyl-activating enzyme (AAE) consensus motif; other site
526226000446	active site
526226000447	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
526226000448	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
526226000449	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
526226000450	active site
526226000451	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
526226000452	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
526226000453	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
526226000454	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
526226000455	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
526226000456	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
526226000457	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526226000458	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
526226000459	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
526226000460	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
526226000461	dimerization interface [polypeptide binding]; other site
526226000462	DPS ferroxidase diiron center [ion binding]; other site
526226000463	ion pore; other site
526226000464	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
526226000465	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226000466	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
526226000467	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
526226000468	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
526226000469	Transcriptional regulator [Transcription]; Region: IclR; COG1414
526226000470	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
526226000471	Bacterial transcriptional regulator; Region: IclR; pfam01614
526226000472	Transcriptional regulator [Transcription]; Region: IclR; COG1414
526226000473	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226000474	putative DNA binding site [nucleotide binding]; other site
526226000475	putative Zn2+ binding site [ion binding]; other site
526226000476	Bacterial transcriptional regulator; Region: IclR; pfam01614
526226000477	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
526226000478	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
526226000479	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526226000480	active site 1 [active]
526226000481	dimer interface [polypeptide binding]; other site
526226000482	hexamer interface [polypeptide binding]; other site
526226000483	active site 2 [active]
526226000484	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
526226000485	conserved cys residue [active]
526226000486	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526226000487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226000488	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226000489	Cytochrome P450; Region: p450; cl12078
526226000490	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
526226000491	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226000492	catalytic loop [active]
526226000493	iron binding site [ion binding]; other site
526226000494	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
526226000495	FAD binding pocket [chemical binding]; other site
526226000496	FAD binding motif [chemical binding]; other site
526226000497	phosphate binding motif [ion binding]; other site
526226000498	beta-alpha-beta structure motif; other site
526226000499	NAD binding pocket [chemical binding]; other site
526226000500	EthD domain; Region: EthD; cl17553
526226000501	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526226000502	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526226000503	active site 1 [active]
526226000504	dimer interface [polypeptide binding]; other site
526226000505	hexamer interface [polypeptide binding]; other site
526226000506	active site 2 [active]
526226000507	short chain dehydrogenase; Provisional; Region: PRK12829
526226000508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226000509	NAD(P) binding site [chemical binding]; other site
526226000510	active site
526226000511	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526226000512	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
526226000513	NAD binding site [chemical binding]; other site
526226000514	catalytic residues [active]
526226000515	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
526226000516	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
526226000517	active site
526226000518	catalytic residues [active]
526226000519	metal binding site [ion binding]; metal-binding site
526226000520	DmpG-like communication domain; Region: DmpG_comm; pfam07836
526226000521	acetaldehyde dehydrogenase; Validated; Region: PRK08300
526226000522	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
526226000523	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
526226000524	N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013
526226000525	tetramer interface [polypeptide binding]; other site
526226000526	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
526226000527	C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014
526226000528	tetramer interface [polypeptide binding]; other site
526226000529	active site
526226000530	metal binding site [ion binding]; metal-binding site
526226000531	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
526226000532	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
526226000533	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
526226000534	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
526226000535	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
526226000536	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
526226000537	Dehydroquinase class II; Region: DHquinase_II; pfam01220
526226000538	active site
526226000539	trimer interface [polypeptide binding]; other site
526226000540	dimer interface [polypeptide binding]; other site
526226000541	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226000542	hydrophobic ligand binding site; other site
526226000543	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226000544	dimerization interface [polypeptide binding]; other site
526226000545	putative DNA binding site [nucleotide binding]; other site
526226000546	putative Zn2+ binding site [ion binding]; other site
526226000547	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526226000548	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
526226000549	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
526226000550	short chain dehydrogenase; Provisional; Region: PRK07904
526226000551	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
526226000552	NAD(P) binding site [chemical binding]; other site
526226000553	active site
526226000554	FAD binding domain; Region: FAD_binding_4; pfam01565
526226000555	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526226000556	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
526226000557	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
526226000558	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526226000559	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226000560	DNA-binding site [nucleotide binding]; DNA binding site
526226000561	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
526226000562	oxidase reductase; Provisional; Region: PTZ00273
526226000563	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
526226000564	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
526226000565	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
526226000566	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226000567	Walker A/P-loop; other site
526226000568	ATP binding site [chemical binding]; other site
526226000569	Q-loop/lid; other site
526226000570	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526226000571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226000572	dimer interface [polypeptide binding]; other site
526226000573	conserved gate region; other site
526226000574	putative PBP binding loops; other site
526226000575	ABC-ATPase subunit interface; other site
526226000576	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
526226000577	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
526226000578	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
526226000579	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
526226000580	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226000581	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526226000582	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526226000583	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526226000584	active site
526226000585	catalytic tetrad [active]
526226000586	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226000587	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226000588	active site
526226000589	Predicted membrane protein [Function unknown]; Region: COG2246
526226000590	GtrA-like protein; Region: GtrA; pfam04138
526226000591	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
526226000592	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226000593	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
526226000594	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
526226000595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226000596	dimer interface [polypeptide binding]; other site
526226000597	conserved gate region; other site
526226000598	putative PBP binding loops; other site
526226000599	ABC-ATPase subunit interface; other site
526226000600	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
526226000601	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526226000602	Walker A/P-loop; other site
526226000603	ATP binding site [chemical binding]; other site
526226000604	Q-loop/lid; other site
526226000605	ABC transporter signature motif; other site
526226000606	Walker B; other site
526226000607	D-loop; other site
526226000608	H-loop/switch region; other site
526226000609	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526226000610	Walker A/P-loop; other site
526226000611	ATP binding site [chemical binding]; other site
526226000612	Q-loop/lid; other site
526226000613	ABC transporter signature motif; other site
526226000614	Walker B; other site
526226000615	D-loop; other site
526226000616	H-loop/switch region; other site
526226000617	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526226000618	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
526226000619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226000620	dimer interface [polypeptide binding]; other site
526226000621	conserved gate region; other site
526226000622	putative PBP binding loops; other site
526226000623	ABC-ATPase subunit interface; other site
526226000624	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
526226000625	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526226000626	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226000627	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
526226000628	Predicted transcriptional regulators [Transcription]; Region: COG1733
526226000629	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526226000630	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526226000631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226000632	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
526226000633	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526226000634	active site
526226000635	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
526226000636	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
526226000637	Walker A/P-loop; other site
526226000638	ATP binding site [chemical binding]; other site
526226000639	Q-loop/lid; other site
526226000640	ABC transporter signature motif; other site
526226000641	Walker B; other site
526226000642	D-loop; other site
526226000643	H-loop/switch region; other site
526226000644	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
526226000645	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526226000646	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
526226000647	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
526226000648	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526226000649	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226000650	catalytic residue [active]
526226000651	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226000652	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226000653	putative DNA binding site [nucleotide binding]; other site
526226000654	putative Zn2+ binding site [ion binding]; other site
526226000655	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
526226000656	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526226000657	NAD(P) binding site [chemical binding]; other site
526226000658	Response regulator receiver domain; Region: Response_reg; pfam00072
526226000659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226000660	active site
526226000661	phosphorylation site [posttranslational modification]
526226000662	intermolecular recognition site; other site
526226000663	dimerization interface [polypeptide binding]; other site
526226000664	Histidine kinase; Region: HisKA_3; pfam07730
526226000665	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526226000666	ATP binding site [chemical binding]; other site
526226000667	Mg2+ binding site [ion binding]; other site
526226000668	G-X-G motif; other site
526226000669	RibD C-terminal domain; Region: RibD_C; cl17279
526226000670	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
526226000671	putative hydrophobic ligand binding site [chemical binding]; other site
526226000672	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226000673	dimerization interface [polypeptide binding]; other site
526226000674	putative DNA binding site [nucleotide binding]; other site
526226000675	putative Zn2+ binding site [ion binding]; other site
526226000676	Protein of unknown function (DUF2781); Region: DUF2781; pfam10914
526226000677	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
526226000678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226000679	putative substrate translocation pore; other site
526226000680	YceI-like domain; Region: YceI; smart00867
526226000681	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
526226000682	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
526226000683	active site
526226000684	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
526226000685	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
526226000686	oligomer interface [polypeptide binding]; other site
526226000687	metal binding site [ion binding]; metal-binding site
526226000688	metal binding site [ion binding]; metal-binding site
526226000689	putative Cl binding site [ion binding]; other site
526226000690	aspartate ring; other site
526226000691	basic sphincter; other site
526226000692	hydrophobic gate; other site
526226000693	periplasmic entrance; other site
526226000694	Acyltransferase family; Region: Acyl_transf_3; pfam01757
526226000695	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
526226000696	active site
526226000697	Putative esterase; Region: Esterase; pfam00756
526226000698	S-formylglutathione hydrolase; Region: PLN02442
526226000699	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
526226000700	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226000701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226000702	homodimer interface [polypeptide binding]; other site
526226000703	catalytic residue [active]
526226000704	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
526226000705	amphipathic channel; other site
526226000706	Asn-Pro-Ala signature motifs; other site
526226000707	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
526226000708	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
526226000709	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
526226000710	prephenate dehydrogenase; Validated; Region: PRK08507
526226000711	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
526226000712	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
526226000713	nucleoside/Zn binding site; other site
526226000714	dimer interface [polypeptide binding]; other site
526226000715	catalytic motif [active]
526226000716	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226000717	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
526226000718	active site
526226000719	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
526226000720	active site
526226000721	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
526226000722	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
526226000723	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226000724	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526226000725	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526226000726	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
526226000727	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
526226000728	FAD binding pocket [chemical binding]; other site
526226000729	FAD binding motif [chemical binding]; other site
526226000730	phosphate binding motif [ion binding]; other site
526226000731	beta-alpha-beta structure motif; other site
526226000732	NAD(p) ribose binding residues [chemical binding]; other site
526226000733	NAD binding pocket [chemical binding]; other site
526226000734	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
526226000735	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226000736	catalytic loop [active]
526226000737	iron binding site [ion binding]; other site
526226000738	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526226000739	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
526226000740	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
526226000741	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
526226000742	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
526226000743	dimer interface [polypeptide binding]; other site
526226000744	acyl-activating enzyme (AAE) consensus motif; other site
526226000745	putative active site [active]
526226000746	AMP binding site [chemical binding]; other site
526226000747	putative CoA binding site [chemical binding]; other site
526226000748	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
526226000749	putative uracil binding site [chemical binding]; other site
526226000750	putative active site [active]
526226000751	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
526226000752	Nuclease-related domain; Region: NERD; pfam08378
526226000753	Family description; Region: UvrD_C_2; pfam13538
526226000754	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
526226000755	Divergent AAA domain; Region: AAA_4; pfam04326
526226000756	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
526226000757	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226000758	putative DNA binding site [nucleotide binding]; other site
526226000759	putative Zn2+ binding site [ion binding]; other site
526226000760	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
526226000761	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
526226000762	putative active site [active]
526226000763	Family description; Region: UvrD_C_2; pfam13538
526226000764	helicase superfamily c-terminal domain; Region: HELICc; smart00490
526226000765	ATP-binding site [chemical binding]; other site
526226000766	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
526226000767	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526226000768	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226000769	ATP binding site [chemical binding]; other site
526226000770	putative Mg++ binding site [ion binding]; other site
526226000771	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226000772	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
526226000773	nucleotide binding region [chemical binding]; other site
526226000774	ATP-binding site [chemical binding]; other site
526226000775	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
526226000776	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
526226000777	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226000778	ATP binding site [chemical binding]; other site
526226000779	putative Mg++ binding site [ion binding]; other site
526226000780	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226000781	ATP-binding site [chemical binding]; other site
526226000782	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
526226000783	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
526226000784	Family description; Region: UvrD_C_2; pfam13538
526226000785	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
526226000786	Part of AAA domain; Region: AAA_19; pfam13245
526226000787	Family description; Region: UvrD_C_2; pfam13538
526226000788	Uncharacterized conserved protein [Function unknown]; Region: COG1479
526226000789	Protein of unknown function DUF262; Region: DUF262; pfam03235
526226000790	Protein of unknown function DUF262; Region: DUF262; pfam03235
526226000791	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
526226000792	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
526226000793	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226000794	ATP binding site [chemical binding]; other site
526226000795	putative Mg++ binding site [ion binding]; other site
526226000796	Winged helix-turn helix; Region: HTH_29; pfam13551
526226000797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
526226000798	Integrase core domain; Region: rve; pfam00665
526226000799	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
526226000800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226000801	Walker A motif; other site
526226000802	ATP binding site [chemical binding]; other site
526226000803	Walker B motif; other site
526226000804	arginine finger; other site
526226000805	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
526226000806	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526226000807	cofactor binding site; other site
526226000808	DNA binding site [nucleotide binding]
526226000809	substrate interaction site [chemical binding]; other site
526226000810	putative transposase OrfB; Reviewed; Region: PHA02517
526226000811	HTH-like domain; Region: HTH_21; pfam13276
526226000812	Integrase core domain; Region: rve; pfam00665
526226000813	Integrase core domain; Region: rve_3; pfam13683
526226000814	Transposase; Region: HTH_Tnp_1; cl17663
526226000815	Transposase; Region: HTH_Tnp_1; cl17663
526226000816	putative transposase OrfB; Reviewed; Region: PHA02517
526226000817	HTH-like domain; Region: HTH_21; pfam13276
526226000818	Integrase core domain; Region: rve; pfam00665
526226000819	Integrase core domain; Region: rve_3; pfam13683
526226000820	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
526226000821	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
526226000822	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
526226000823	Transposase; Region: DDE_Tnp_ISL3; pfam01610
526226000824	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
526226000825	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226000826	ATP binding site [chemical binding]; other site
526226000827	putative Mg++ binding site [ion binding]; other site
526226000828	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226000829	nucleotide binding region [chemical binding]; other site
526226000830	ATP-binding site [chemical binding]; other site
526226000831	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
526226000832	active site
526226000833	SnoaL-like domain; Region: SnoaL_4; pfam13577
526226000834	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
526226000835	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226000836	Coenzyme A binding pocket [chemical binding]; other site
526226000837	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
526226000838	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
526226000839	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526226000840	PYR/PP interface [polypeptide binding]; other site
526226000841	dimer interface [polypeptide binding]; other site
526226000842	TPP binding site [chemical binding]; other site
526226000843	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526226000844	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
526226000845	TPP-binding site [chemical binding]; other site
526226000846	putative transposase OrfB; Reviewed; Region: PHA02517
526226000847	HTH-like domain; Region: HTH_21; pfam13276
526226000848	Integrase core domain; Region: rve; pfam00665
526226000849	Integrase core domain; Region: rve_3; pfam13683
526226000850	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
526226000851	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
526226000852	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526226000853	metal ion-dependent adhesion site (MIDAS); other site
526226000854	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526226000855	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
526226000856	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
526226000857	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
526226000858	active site
526226000859	catalytic site [active]
526226000860	YCII-related domain; Region: YCII; cl00999
526226000861	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
526226000862	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526226000863	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
526226000864	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526226000865	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
526226000866	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
526226000867	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526226000868	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
526226000869	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
526226000870	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
526226000871	4Fe-4S binding domain; Region: Fer4; pfam00037
526226000872	4Fe-4S binding domain; Region: Fer4; pfam00037
526226000873	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
526226000874	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
526226000875	NADH dehydrogenase subunit G; Validated; Region: PRK07860
526226000876	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226000877	catalytic loop [active]
526226000878	iron binding site [ion binding]; other site
526226000879	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
526226000880	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526226000881	molybdopterin cofactor binding site; other site
526226000882	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
526226000883	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
526226000884	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
526226000885	putative dimer interface [polypeptide binding]; other site
526226000886	[2Fe-2S] cluster binding site [ion binding]; other site
526226000887	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
526226000888	SLBB domain; Region: SLBB; pfam10531
526226000889	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
526226000890	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
526226000891	NADH dehydrogenase subunit D; Validated; Region: PRK06075
526226000892	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
526226000893	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
526226000894	NADH dehydrogenase subunit B; Validated; Region: PRK06411
526226000895	NADH dehydrogenase subunit A; Validated; Region: PRK07928
526226000896	Proteins of 100 residues with WXG; Region: WXG100; cl02005
526226000897	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
526226000898	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226000899	hydrophobic ligand binding site; other site
526226000900	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
526226000901	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
526226000902	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
526226000903	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
526226000904	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526226000905	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526226000906	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526226000907	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526226000908	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
526226000909	DNA binding residues [nucleotide binding]
526226000910	dimer interface [polypeptide binding]; other site
526226000911	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
526226000912	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
526226000913	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
526226000914	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526226000915	Domain of unknown function DUF21; Region: DUF21; pfam01595
526226000916	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526226000917	Transporter associated domain; Region: CorC_HlyC; pfam03471
526226000918	Domain of unknown function DUF21; Region: DUF21; pfam01595
526226000919	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526226000920	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
526226000921	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
526226000922	active site
526226000923	HIGH motif; other site
526226000924	nucleotide binding site [chemical binding]; other site
526226000925	active site
526226000926	KMSKS motif; other site
526226000927	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
526226000928	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
526226000929	active site
526226000930	DNA binding site [nucleotide binding]
526226000931	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
526226000932	DNA binding site [nucleotide binding]
526226000933	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
526226000934	nucleotide binding site [chemical binding]; other site
526226000935	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
526226000936	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
526226000937	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
526226000938	Htaa; Region: HtaA; pfam04213
526226000939	NmrA-like family; Region: NmrA; pfam05368
526226000940	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
526226000941	NADP binding site [chemical binding]; other site
526226000942	active site
526226000943	regulatory binding site [polypeptide binding]; other site
526226000944	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526226000945	Fic/DOC family; Region: Fic; cl00960
526226000946	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
526226000947	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226000948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226000949	homodimer interface [polypeptide binding]; other site
526226000950	catalytic residue [active]
526226000951	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
526226000952	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226000953	Walker A motif; other site
526226000954	ATP binding site [chemical binding]; other site
526226000955	Walker B motif; other site
526226000956	arginine finger; other site
526226000957	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
526226000958	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
526226000959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226000960	S-adenosylmethionine binding site [chemical binding]; other site
526226000961	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526226000962	FAD binding domain; Region: FAD_binding_4; pfam01565
526226000963	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
526226000964	hydrophobic ligand binding site; other site
526226000965	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
526226000966	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
526226000967	active site
526226000968	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226000969	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526226000970	active site
526226000971	metal binding site [ion binding]; metal-binding site
526226000972	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526226000973	active site
526226000974	RibD C-terminal domain; Region: RibD_C; cl17279
526226000975	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
526226000976	recombination protein RecR; Reviewed; Region: recR; PRK00076
526226000977	RecR protein; Region: RecR; pfam02132
526226000978	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
526226000979	putative active site [active]
526226000980	putative metal-binding site [ion binding]; other site
526226000981	tetramer interface [polypeptide binding]; other site
526226000982	TAP-like protein; Region: Abhydrolase_4; pfam08386
526226000983	hypothetical protein; Provisional; Region: PRK06547
526226000984	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
526226000985	Fe-S cluster binding site [ion binding]; other site
526226000986	DNA binding site [nucleotide binding]
526226000987	active site
526226000988	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
526226000989	catalytic triad [active]
526226000990	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526226000991	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
526226000992	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
526226000993	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
526226000994	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
526226000995	EamA-like transporter family; Region: EamA; pfam00892
526226000996	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
526226000997	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
526226000998	active site
526226000999	tetramer interface [polypeptide binding]; other site
526226001000	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
526226001001	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
526226001002	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226001003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226001004	Coenzyme A binding pocket [chemical binding]; other site
526226001005	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526226001006	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226001007	putative DNA binding site [nucleotide binding]; other site
526226001008	dimerization interface [polypeptide binding]; other site
526226001009	putative Zn2+ binding site [ion binding]; other site
526226001010	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
526226001011	putative dimerization interface [polypeptide binding]; other site
526226001012	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226001013	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226001014	active site
526226001015	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226001016	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226001017	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
526226001018	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
526226001019	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226001020	dimer interface [polypeptide binding]; other site
526226001021	active site
526226001022	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
526226001023	2-isopropylmalate synthase; Validated; Region: PRK03739
526226001024	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
526226001025	active site
526226001026	catalytic residues [active]
526226001027	metal binding site [ion binding]; metal-binding site
526226001028	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
526226001029	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
526226001030	FMN binding site [chemical binding]; other site
526226001031	dimer interface [polypeptide binding]; other site
526226001032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226001033	putative substrate translocation pore; other site
526226001034	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226001035	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226001036	aspartate kinase; Reviewed; Region: PRK06635
526226001037	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
526226001038	putative nucleotide binding site [chemical binding]; other site
526226001039	putative catalytic residues [active]
526226001040	putative Mg ion binding site [ion binding]; other site
526226001041	putative aspartate binding site [chemical binding]; other site
526226001042	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
526226001043	putative allosteric regulatory site; other site
526226001044	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
526226001045	putative allosteric regulatory residue; other site
526226001046	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
526226001047	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
526226001048	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
526226001049	active site
526226001050	catalytic site [active]
526226001051	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226001052	active site 2 [active]
526226001053	active site 1 [active]
526226001054	Secretory lipase; Region: LIP; pfam03583
526226001055	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
526226001056	metal binding site 2 [ion binding]; metal-binding site
526226001057	putative DNA binding helix; other site
526226001058	metal binding site 1 [ion binding]; metal-binding site
526226001059	dimer interface [polypeptide binding]; other site
526226001060	structural Zn2+ binding site [ion binding]; other site
526226001061	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
526226001062	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
526226001063	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
526226001064	dimerization interface [polypeptide binding]; other site
526226001065	DPS ferroxidase diiron center [ion binding]; other site
526226001066	ion pore; other site
526226001067	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
526226001068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
526226001069	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
526226001070	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226001071	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226001072	DNA binding residues [nucleotide binding]
526226001073	dimerization interface [polypeptide binding]; other site
526226001074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226001075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226001076	hypothetical protein; Provisional; Region: PRK07907
526226001077	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
526226001078	active site
526226001079	metal binding site [ion binding]; metal-binding site
526226001080	dimer interface [polypeptide binding]; other site
526226001081	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226001082	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226001083	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
526226001084	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526226001085	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
526226001086	active site
526226001087	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
526226001088	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526226001089	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226001090	substrate binding site [chemical binding]; other site
526226001091	oxyanion hole (OAH) forming residues; other site
526226001092	trimer interface [polypeptide binding]; other site
526226001093	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
526226001094	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226001095	motif I; other site
526226001096	motif II; other site
526226001097	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
526226001098	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526226001099	putative active site [active]
526226001100	putative metal binding site [ion binding]; other site
526226001101	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
526226001102	Transglycosylase; Region: Transgly; pfam00912
526226001103	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526226001104	Transcription factor WhiB; Region: Whib; pfam02467
526226001105	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
526226001106	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
526226001107	DTAP/Switch II; other site
526226001108	Switch I; other site
526226001109	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
526226001110	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
526226001111	DTAP/Switch II; other site
526226001112	Switch I; other site
526226001113	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
526226001114	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
526226001115	homotrimer interaction site [polypeptide binding]; other site
526226001116	putative active site [active]
526226001117	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
526226001118	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
526226001119	conserved cys residue [active]
526226001120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226001121	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226001122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226001123	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226001124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
526226001125	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
526226001126	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526226001127	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526226001128	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526226001129	ligand binding site [chemical binding]; other site
526226001130	flexible hinge region; other site
526226001131	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
526226001132	putative switch regulator; other site
526226001133	non-specific DNA interactions [nucleotide binding]; other site
526226001134	DNA binding site [nucleotide binding]
526226001135	sequence specific DNA binding site [nucleotide binding]; other site
526226001136	putative cAMP binding site [chemical binding]; other site
526226001137	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
526226001138	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526226001139	minor groove reading motif; other site
526226001140	helix-hairpin-helix signature motif; other site
526226001141	substrate binding pocket [chemical binding]; other site
526226001142	active site
526226001143	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
526226001144	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526226001145	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526226001146	catalytic residues [active]
526226001147	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
526226001148	putative active site [active]
526226001149	putative CoA binding site [chemical binding]; other site
526226001150	nudix motif; other site
526226001151	metal binding site [ion binding]; metal-binding site
526226001152	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
526226001153	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526226001154	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226001155	PGAP1-like protein; Region: PGAP1; pfam07819
526226001156	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
526226001157	acetyl-CoA synthetase; Provisional; Region: PRK00174
526226001158	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
526226001159	active site
526226001160	CoA binding site [chemical binding]; other site
526226001161	acyl-activating enzyme (AAE) consensus motif; other site
526226001162	AMP binding site [chemical binding]; other site
526226001163	acetate binding site [chemical binding]; other site
526226001164	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
526226001165	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226001166	motif II; other site
526226001167	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
526226001168	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
526226001169	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
526226001170	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
526226001171	ATP binding site [chemical binding]; other site
526226001172	Walker A motif; other site
526226001173	hexamer interface [polypeptide binding]; other site
526226001174	Walker B motif; other site
526226001175	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
526226001176	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526226001177	DNA-binding site [nucleotide binding]; DNA binding site
526226001178	RNA-binding motif; other site
526226001179	VRR-NUC domain; Region: VRR_NUC; pfam08774
526226001180	Antirestriction protein (ArdA); Region: ArdA; cl01953
526226001181	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
526226001182	additional DNA contacts [nucleotide binding]; other site
526226001183	mismatch recognition site; other site
526226001184	active site
526226001185	zinc binding site [ion binding]; other site
526226001186	DNA intercalation site [nucleotide binding]; other site
526226001187	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526226001188	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
526226001189	cofactor binding site; other site
526226001190	DNA binding site [nucleotide binding]
526226001191	substrate interaction site [chemical binding]; other site
526226001192	Catalytic GIY-YIG domain of type II restriction enzyme R.Cfr42I and similar proteins; Region: GIY-YIG_RE_Cfr42I; cd10453
526226001193	GIY-YIG motif/motif A; other site
526226001194	putative active site [active]
526226001195	putative metal binding site [ion binding]; other site
526226001196	Catalytic GIY-YIG domain of type II restriction endonucleases R.Eco29kI, R.Cfr42I, and similar proteins; Region: GIY-YIG_RE_Eco29kI_like; cd10435
526226001197	GIY-YIG motif/motif A; other site
526226001198	active site
526226001199	DNA binding site [nucleotide binding]
526226001200	homodimer interface [polypeptide binding]; other site
526226001201	putative metal binding site [ion binding]; other site
526226001202	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526226001203	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
526226001204	catalytic residues [active]
526226001205	catalytic nucleophile [active]
526226001206	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
526226001207	DNA-binding interface [nucleotide binding]; DNA binding site
526226001208	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226001209	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226001210	salt bridge; other site
526226001211	non-specific DNA binding site [nucleotide binding]; other site
526226001212	sequence-specific DNA binding site [nucleotide binding]; other site
526226001213	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526226001214	Walker A motif; other site
526226001215	ATP binding site [chemical binding]; other site
526226001216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
526226001217	Transposase; Region: DDE_Tnp_ISL3; pfam01610
526226001218	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
526226001219	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
526226001220	catalytic residues [active]
526226001221	D5 N terminal like; Region: D5_N; smart00885
526226001222	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
526226001223	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
526226001224	Helix-turn-helix domain; Region: HTH_17; cl17695
526226001225	Helix-turn-helix domain; Region: HTH_17; cl17695
526226001226	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526226001227	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
526226001228	catalytic residues [active]
526226001229	catalytic nucleophile [active]
526226001230	Recombinase; Region: Recombinase; pfam07508
526226001231	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
526226001232	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
526226001233	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
526226001234	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226001235	ATP binding site [chemical binding]; other site
526226001236	putative Mg++ binding site [ion binding]; other site
526226001237	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226001238	nucleotide binding region [chemical binding]; other site
526226001239	ATP-binding site [chemical binding]; other site
526226001240	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
526226001241	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526226001242	DNA-binding site [nucleotide binding]; DNA binding site
526226001243	RNA-binding motif; other site
526226001244	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
526226001245	DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051
526226001246	active site
526226001247	interdomain interaction site; other site
526226001248	putative metal-binding site [ion binding]; other site
526226001249	nucleotide binding site [chemical binding]; other site
526226001250	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
526226001251	domain I; other site
526226001252	DNA binding groove [nucleotide binding]
526226001253	phosphate binding site [ion binding]; other site
526226001254	domain II; other site
526226001255	domain III; other site
526226001256	nucleotide binding site [chemical binding]; other site
526226001257	catalytic site [active]
526226001258	domain IV; other site
526226001259	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
526226001260	Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754
526226001261	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
526226001262	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
526226001263	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526226001264	dimerization interface [polypeptide binding]; other site
526226001265	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526226001266	cyclase homology domain; Region: CHD; cd07302
526226001267	nucleotidyl binding site; other site
526226001268	metal binding site [ion binding]; metal-binding site
526226001269	dimer interface [polypeptide binding]; other site
526226001270	DNA polymerase III subunit delta'; Validated; Region: PRK07940
526226001271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
526226001272	DNA polymerase III subunit delta'; Validated; Region: PRK08485
526226001273	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526226001274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226001275	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
526226001276	putative dimerization interface [polypeptide binding]; other site
526226001277	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
526226001278	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
526226001279	NAD binding site [chemical binding]; other site
526226001280	substrate binding site [chemical binding]; other site
526226001281	catalytic Zn binding site [ion binding]; other site
526226001282	tetramer interface [polypeptide binding]; other site
526226001283	structural Zn binding site [ion binding]; other site
526226001284	Lipase (class 2); Region: Lipase_2; pfam01674
526226001285	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226001286	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226001287	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
526226001288	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226001289	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526226001290	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226001291	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
526226001292	aromatic arch; other site
526226001293	DCoH dimer interaction site [polypeptide binding]; other site
526226001294	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
526226001295	DCoH tetramer interaction site [polypeptide binding]; other site
526226001296	substrate binding site [chemical binding]; other site
526226001297	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
526226001298	Malic enzyme, N-terminal domain; Region: malic; pfam00390
526226001299	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
526226001300	putative NAD(P) binding site [chemical binding]; other site
526226001301	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
526226001302	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226001303	DNA-binding site [nucleotide binding]; DNA binding site
526226001304	FCD domain; Region: FCD; cl11656
526226001305	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
526226001306	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
526226001307	UDP-glucose 4-epimerase; Region: PLN02240
526226001308	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
526226001309	NAD binding site [chemical binding]; other site
526226001310	homodimer interface [polypeptide binding]; other site
526226001311	active site
526226001312	substrate binding site [chemical binding]; other site
526226001313	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226001314	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226001315	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526226001316	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
526226001317	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
526226001318	NAD binding site [chemical binding]; other site
526226001319	substrate binding site [chemical binding]; other site
526226001320	homodimer interface [polypeptide binding]; other site
526226001321	active site
526226001322	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
526226001323	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
526226001324	substrate binding site; other site
526226001325	tetramer interface; other site
526226001326	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
526226001327	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
526226001328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226001329	Walker A/P-loop; other site
526226001330	ATP binding site [chemical binding]; other site
526226001331	Q-loop/lid; other site
526226001332	ABC transporter signature motif; other site
526226001333	Walker B; other site
526226001334	D-loop; other site
526226001335	H-loop/switch region; other site
526226001336	EXLDI protein; Region: EXLDI; TIGR04342
526226001337	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
526226001338	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526226001339	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
526226001340	Ligand binding site; other site
526226001341	Putative Catalytic site; other site
526226001342	DXD motif; other site
526226001343	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526226001344	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526226001345	active site
526226001346	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
526226001347	Peptidase family M1; Region: Peptidase_M1; pfam01433
526226001348	Zn binding site [ion binding]; other site
526226001349	Predicted membrane protein [Function unknown]; Region: COG2259
526226001350	Translocation protein Sec62; Region: Sec62; cl02170
526226001351	Clp amino terminal domain; Region: Clp_N; pfam02861
526226001352	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
526226001353	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
526226001354	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
526226001355	Methyltransferase domain; Region: Methyltransf_25; pfam13649
526226001356	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
526226001357	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
526226001358	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
526226001359	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
526226001360	Short C-terminal domain; Region: SHOCT; pfam09851
526226001361	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
526226001362	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226001363	active site
526226001364	motif I; other site
526226001365	motif II; other site
526226001366	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226001367	motif II; other site
526226001368	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
526226001369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226001370	putative PBP binding loops; other site
526226001371	ABC-ATPase subunit interface; other site
526226001372	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
526226001373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226001374	dimer interface [polypeptide binding]; other site
526226001375	conserved gate region; other site
526226001376	putative PBP binding loops; other site
526226001377	ABC-ATPase subunit interface; other site
526226001378	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
526226001379	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526226001380	Walker A/P-loop; other site
526226001381	ATP binding site [chemical binding]; other site
526226001382	Q-loop/lid; other site
526226001383	ABC transporter signature motif; other site
526226001384	Walker B; other site
526226001385	D-loop; other site
526226001386	H-loop/switch region; other site
526226001387	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526226001388	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
526226001389	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526226001390	Walker A/P-loop; other site
526226001391	ATP binding site [chemical binding]; other site
526226001392	Q-loop/lid; other site
526226001393	ABC transporter signature motif; other site
526226001394	Walker B; other site
526226001395	D-loop; other site
526226001396	H-loop/switch region; other site
526226001397	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
526226001398	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
526226001399	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526226001400	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
526226001401	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
526226001402	acyl-activating enzyme (AAE) consensus motif; other site
526226001403	active site
526226001404	AMP binding site [chemical binding]; other site
526226001405	substrate binding site [chemical binding]; other site
526226001406	salicylate synthase MbtI; Reviewed; Region: PRK07912
526226001407	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
526226001408	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
526226001409	Condensation domain; Region: Condensation; pfam00668
526226001410	Nonribosomal peptide synthase; Region: NRPS; pfam08415
526226001411	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
526226001412	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226001413	acyl-activating enzyme (AAE) consensus motif; other site
526226001414	AMP binding site [chemical binding]; other site
526226001415	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226001416	Homeodomain-like domain; Region: HTH_23; pfam13384
526226001417	Winged helix-turn helix; Region: HTH_29; pfam13551
526226001418	Homeodomain-like domain; Region: HTH_32; pfam13565
526226001419	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226001420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226001421	Condensation domain; Region: Condensation; pfam00668
526226001422	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226001423	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226001424	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226001425	acyl-activating enzyme (AAE) consensus motif; other site
526226001426	AMP binding site [chemical binding]; other site
526226001427	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226001428	Condensation domain; Region: Condensation; pfam00668
526226001429	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226001430	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226001431	Phosphopantetheine attachment site; Region: PP-binding; cl09936
526226001432	Uncharacterized conserved protein [Function unknown]; Region: COG3391
526226001433	Predicted transcriptional regulators [Transcription]; Region: COG1733
526226001434	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
526226001435	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
526226001436	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
526226001437	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
526226001438	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
526226001439	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
526226001440	NADP binding site [chemical binding]; other site
526226001441	active site
526226001442	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226001443	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
526226001444	Methyltransferase domain; Region: Methyltransf_12; pfam08242
526226001445	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
526226001446	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
526226001447	Condensation domain; Region: Condensation; pfam00668
526226001448	Chloramphenicol acetyltransferase; Region: CAT; cl02008
526226001449	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226001450	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226001451	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226001452	acyl-activating enzyme (AAE) consensus motif; other site
526226001453	AMP binding site [chemical binding]; other site
526226001454	Condensation domain; Region: Condensation; pfam00668
526226001455	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
526226001456	Condensation domain; Region: Condensation; pfam00668
526226001457	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226001458	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226001459	acyl-activating enzyme (AAE) consensus motif; other site
526226001460	AMP binding site [chemical binding]; other site
526226001461	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226001462	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
526226001463	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
526226001464	active site
526226001465	substrate binding site [chemical binding]; other site
526226001466	cosubstrate binding site; other site
526226001467	catalytic site [active]
526226001468	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
526226001469	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226001470	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
526226001471	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
526226001472	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
526226001473	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
526226001474	active site
526226001475	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
526226001476	putative FMN binding site [chemical binding]; other site
526226001477	NADPH bind site [chemical binding]; other site
526226001478	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
526226001479	Isochorismatase family; Region: Isochorismatase; pfam00857
526226001480	catalytic triad [active]
526226001481	conserved cis-peptide bond; other site
526226001482	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
526226001483	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526226001484	intersubunit interface [polypeptide binding]; other site
526226001485	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
526226001486	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
526226001487	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
526226001488	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226001489	acyl-activating enzyme (AAE) consensus motif; other site
526226001490	AMP binding site [chemical binding]; other site
526226001491	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226001492	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
526226001493	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
526226001494	acyl-activating enzyme (AAE) consensus motif; other site
526226001495	active site
526226001496	AMP binding site [chemical binding]; other site
526226001497	substrate binding site [chemical binding]; other site
526226001498	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226001499	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
526226001500	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526226001501	dimer interface [polypeptide binding]; other site
526226001502	putative PBP binding regions; other site
526226001503	ABC-ATPase subunit  interface; other site
526226001504	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
526226001505	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526226001506	ABC-ATPase subunit  interface; other site
526226001507	dimer interface [polypeptide binding]; other site
526226001508	putative PBP binding regions; other site
526226001509	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526226001510	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
526226001511	Walker A/P-loop; other site
526226001512	ATP binding site [chemical binding]; other site
526226001513	Q-loop/lid; other site
526226001514	ABC transporter signature motif; other site
526226001515	Walker B; other site
526226001516	D-loop; other site
526226001517	H-loop/switch region; other site
526226001518	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526226001519	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
526226001520	metal binding site [ion binding]; metal-binding site
526226001521	putative dimer interface [polypeptide binding]; other site
526226001522	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
526226001523	dimer interface [polypeptide binding]; other site
526226001524	substrate binding site [chemical binding]; other site
526226001525	ATP binding site [chemical binding]; other site
526226001526	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
526226001527	ThiC-associated domain; Region: ThiC-associated; pfam13667
526226001528	ThiC family; Region: ThiC; pfam01964
526226001529	Predicted acetyltransferase [General function prediction only]; Region: COG2388
526226001530	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
526226001531	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
526226001532	FAD binding pocket [chemical binding]; other site
526226001533	FAD binding motif [chemical binding]; other site
526226001534	phosphate binding motif [ion binding]; other site
526226001535	NAD binding pocket [chemical binding]; other site
526226001536	ABC-2 type transporter; Region: ABC2_membrane; cl17235
526226001537	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
526226001538	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526226001539	ABC-2 type transporter; Region: ABC2_membrane; cl17235
526226001540	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
526226001541	putative catalytic site [active]
526226001542	putative phosphate binding site [ion binding]; other site
526226001543	active site
526226001544	metal binding site A [ion binding]; metal-binding site
526226001545	DNA binding site [nucleotide binding]
526226001546	putative AP binding site [nucleotide binding]; other site
526226001547	putative metal binding site B [ion binding]; other site
526226001548	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
526226001549	RNAase interaction site [polypeptide binding]; other site
526226001550	ribonuclease; Region: Ribonuclease; pfam00545
526226001551	active site
526226001552	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526226001553	Coenzyme A binding pocket [chemical binding]; other site
526226001554	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
526226001555	active site
526226001556	catalytic residues [active]
526226001557	metal binding site [ion binding]; metal-binding site
526226001558	Lipase (class 2); Region: Lipase_2; pfam01674
526226001559	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
526226001560	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526226001561	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
526226001562	E-class dimer interface [polypeptide binding]; other site
526226001563	P-class dimer interface [polypeptide binding]; other site
526226001564	active site
526226001565	Cu2+ binding site [ion binding]; other site
526226001566	Zn2+ binding site [ion binding]; other site
526226001567	carboxylate-amine ligase; Provisional; Region: PRK13517
526226001568	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
526226001569	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
526226001570	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
526226001571	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
526226001572	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
526226001573	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526226001574	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
526226001575	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
526226001576	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
526226001577	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
526226001578	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
526226001579	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
526226001580	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
526226001581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226001582	Walker A motif; other site
526226001583	ATP binding site [chemical binding]; other site
526226001584	Walker B motif; other site
526226001585	arginine finger; other site
526226001586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226001587	Walker A motif; other site
526226001588	ATP binding site [chemical binding]; other site
526226001589	Walker B motif; other site
526226001590	arginine finger; other site
526226001591	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
526226001592	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
526226001593	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
526226001594	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
526226001595	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
526226001596	dimer interface [polypeptide binding]; other site
526226001597	putative functional site; other site
526226001598	putative MPT binding site; other site
526226001599	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
526226001600	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226001601	active site
526226001602	motif I; other site
526226001603	motif II; other site
526226001604	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226001605	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
526226001606	hydrophobic ligand binding site; other site
526226001607	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
526226001608	Predicted transcriptional regulator [Transcription]; Region: COG2378
526226001609	HTH domain; Region: HTH_11; pfam08279
526226001610	WYL domain; Region: WYL; pfam13280
526226001611	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526226001612	homotrimer interaction site [polypeptide binding]; other site
526226001613	putative active site [active]
526226001614	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226001615	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
526226001616	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
526226001617	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226001618	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
526226001619	active site
526226001620	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
526226001621	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226001622	active site
526226001623	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226001624	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226001625	amidase; Provisional; Region: PRK07869
526226001626	Amidase; Region: Amidase; cl11426
526226001627	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
526226001628	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
526226001629	Na binding site [ion binding]; other site
526226001630	Protein of unknown function, DUF485; Region: DUF485; pfam04341
526226001631	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526226001632	putative active site [active]
526226001633	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
526226001634	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
526226001635	Na binding site [ion binding]; other site
526226001636	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
526226001637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226001638	active site
526226001639	phosphorylation site [posttranslational modification]
526226001640	intermolecular recognition site; other site
526226001641	dimerization interface [polypeptide binding]; other site
526226001642	LytTr DNA-binding domain; Region: LytTR; smart00850
526226001643	Histidine kinase; Region: His_kinase; pfam06580
526226001644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226001645	ATP binding site [chemical binding]; other site
526226001646	Mg2+ binding site [ion binding]; other site
526226001647	G-X-G motif; other site
526226001648	spermidine synthase; Provisional; Region: PRK03612
526226001649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226001650	S-adenosylmethionine binding site [chemical binding]; other site
526226001651	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
526226001652	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
526226001653	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
526226001654	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
526226001655	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
526226001656	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
526226001657	ring oligomerisation interface [polypeptide binding]; other site
526226001658	ATP/Mg binding site [chemical binding]; other site
526226001659	stacking interactions; other site
526226001660	hinge regions; other site
526226001661	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
526226001662	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526226001663	intersubunit interface [polypeptide binding]; other site
526226001664	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
526226001665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226001666	Transposase; Region: HTH_Tnp_1; cl17663
526226001667	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226001668	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226001669	salt bridge; other site
526226001670	non-specific DNA binding site [nucleotide binding]; other site
526226001671	sequence-specific DNA binding site [nucleotide binding]; other site
526226001672	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
526226001673	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
526226001674	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
526226001675	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
526226001676	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226001677	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526226001678	active site
526226001679	ATP binding site [chemical binding]; other site
526226001680	substrate binding site [chemical binding]; other site
526226001681	activation loop (A-loop); other site
526226001682	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
526226001683	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526226001684	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526226001685	active site
526226001686	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
526226001687	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226001688	putative ADP-binding pocket [chemical binding]; other site
526226001689	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226001690	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526226001691	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526226001692	CoenzymeA binding site [chemical binding]; other site
526226001693	subunit interaction site [polypeptide binding]; other site
526226001694	PHB binding site; other site
526226001695	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226001696	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226001697	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
526226001698	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
526226001699	putative hydrophobic ligand binding site [chemical binding]; other site
526226001700	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
526226001701	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
526226001702	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
526226001703	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526226001704	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526226001705	Beta-lactamase; Region: Beta-lactamase; pfam00144
526226001706	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
526226001707	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
526226001708	Helix-turn-helix domain; Region: HTH_38; pfam13936
526226001709	Integrase core domain; Region: rve; pfam00665
526226001710	putative transposase OrfB; Reviewed; Region: PHA02517
526226001711	HTH-like domain; Region: HTH_21; pfam13276
526226001712	Integrase core domain; Region: rve; pfam00665
526226001713	Integrase core domain; Region: rve_3; pfam13683
526226001714	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
526226001715	Transposase; Region: DDE_Tnp_ISL3; pfam01610
526226001716	Transposase; Region: HTH_Tnp_1; cl17663
526226001717	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226001718	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226001719	active site
526226001720	putative transposase OrfB; Reviewed; Region: PHA02517
526226001721	HTH-like domain; Region: HTH_21; pfam13276
526226001722	Integrase core domain; Region: rve; pfam00665
526226001723	Integrase core domain; Region: rve_3; pfam13683
526226001724	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
526226001725	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
526226001726	active site
526226001727	FMN binding site [chemical binding]; other site
526226001728	substrate binding site [chemical binding]; other site
526226001729	putative catalytic residue [active]
526226001730	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226001731	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226001732	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
526226001733	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226001734	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526226001735	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
526226001736	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
526226001737	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
526226001738	minor groove reading motif; other site
526226001739	helix-hairpin-helix signature motif; other site
526226001740	active site
526226001741	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
526226001742	DNA binding site [nucleotide binding]
526226001743	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
526226001744	AAA ATPase domain; Region: AAA_16; pfam13191
526226001745	Predicted ATPase [General function prediction only]; Region: COG3899
526226001746	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526226001747	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226001748	Walker A/P-loop; other site
526226001749	ATP binding site [chemical binding]; other site
526226001750	Q-loop/lid; other site
526226001751	ABC transporter signature motif; other site
526226001752	Walker B; other site
526226001753	D-loop; other site
526226001754	H-loop/switch region; other site
526226001755	FaeA-like protein; Region: FaeA; pfam04703
526226001756	Methyltransferase domain; Region: Methyltransf_11; pfam08241
526226001757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526226001758	Methyltransferase domain; Region: Methyltransf_23; pfam13489
526226001759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226001760	S-adenosylmethionine binding site [chemical binding]; other site
526226001761	Uncharacterized conserved protein [Function unknown]; Region: COG2128
526226001762	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
526226001763	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
526226001764	putative active site [active]
526226001765	putative catalytic site [active]
526226001766	Secretory lipase; Region: LIP; pfam03583
526226001767	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226001768	Secretory lipase; Region: LIP; pfam03583
526226001769	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226001770	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226001771	non-specific DNA binding site [nucleotide binding]; other site
526226001772	salt bridge; other site
526226001773	sequence-specific DNA binding site [nucleotide binding]; other site
526226001774	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
526226001775	Domain of unknown function (DUF955); Region: DUF955; pfam06114
526226001776	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
526226001777	isocitrate lyase; Provisional; Region: PRK15063
526226001778	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
526226001779	tetramer interface [polypeptide binding]; other site
526226001780	active site
526226001781	Mg2+/Mn2+ binding site [ion binding]; other site
526226001782	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
526226001783	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
526226001784	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
526226001785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226001786	sequence-specific DNA binding site [nucleotide binding]; other site
526226001787	salt bridge; other site
526226001788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226001789	S-adenosylmethionine binding site [chemical binding]; other site
526226001790	Benzoate membrane transport protein; Region: BenE; pfam03594
526226001791	benzoate transporter; Region: benE; TIGR00843
526226001792	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
526226001793	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226001794	short chain dehydrogenase; Provisional; Region: PRK08303
526226001795	NAD(P) binding site [chemical binding]; other site
526226001796	active site
526226001797	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226001798	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226001799	Predicted membrane protein [Function unknown]; Region: COG2733
526226001800	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226001801	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226001802	non-specific DNA binding site [nucleotide binding]; other site
526226001803	salt bridge; other site
526226001804	sequence-specific DNA binding site [nucleotide binding]; other site
526226001805	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
526226001806	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
526226001807	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526226001808	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526226001809	DNA binding residues [nucleotide binding]
526226001810	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226001811	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226001812	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526226001813	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
526226001814	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
526226001815	FAD binding domain; Region: FAD_binding_4; pfam01565
526226001816	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
526226001817	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
526226001818	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
526226001819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526226001820	Predicted amidohydrolase [General function prediction only]; Region: COG0388
526226001821	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
526226001822	putative active site [active]
526226001823	catalytic triad [active]
526226001824	putative dimer interface [polypeptide binding]; other site
526226001825	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526226001826	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
526226001827	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
526226001828	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
526226001829	putative active site [active]
526226001830	putative substrate binding site [chemical binding]; other site
526226001831	putative cosubstrate binding site; other site
526226001832	catalytic site [active]
526226001833	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
526226001834	intersubunit interface [polypeptide binding]; other site
526226001835	active site
526226001836	catalytic residue [active]
526226001837	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226001838	dimerization interface [polypeptide binding]; other site
526226001839	putative DNA binding site [nucleotide binding]; other site
526226001840	putative Zn2+ binding site [ion binding]; other site
526226001841	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
526226001842	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226001843	putative metal binding site [ion binding]; other site
526226001844	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526226001845	Low molecular weight phosphatase family; Region: LMWPc; cl00105
526226001846	active site
526226001847	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526226001848	Low molecular weight phosphatase family; Region: LMWPc; cd00115
526226001849	active site
526226001850	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526226001851	Low molecular weight phosphatase family; Region: LMWPc; cl00105
526226001852	active site
526226001853	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
526226001854	arsenical-resistance protein; Region: acr3; TIGR00832
526226001855	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226001856	dimerization interface [polypeptide binding]; other site
526226001857	putative DNA binding site [nucleotide binding]; other site
526226001858	putative Zn2+ binding site [ion binding]; other site
526226001859	Helix-turn-helix domain; Region: HTH_28; pfam13518
526226001860	Winged helix-turn helix; Region: HTH_29; pfam13551
526226001861	Integrase core domain; Region: rve; pfam00665
526226001862	DDE domain; Region: DDE_Tnp_IS240; pfam13610
526226001863	Integrase core domain; Region: rve_3; pfam13683
526226001864	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226001865	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
526226001866	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
526226001867	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226001868	non-specific DNA binding site [nucleotide binding]; other site
526226001869	salt bridge; other site
526226001870	sequence-specific DNA binding site [nucleotide binding]; other site
526226001871	Cupin domain; Region: Cupin_2; pfam07883
526226001872	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
526226001873	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
526226001874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
526226001875	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526226001876	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226001877	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
526226001878	NAD(P) binding site [chemical binding]; other site
526226001879	active site
526226001880	MarR family; Region: MarR_2; pfam12802
526226001881	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526226001882	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526226001883	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
526226001884	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
526226001885	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
526226001886	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
526226001887	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
526226001888	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
526226001889	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
526226001890	active site
526226001891	homotetramer interface [polypeptide binding]; other site
526226001892	Uncharacterized conserved protein [Function unknown]; Region: COG2966
526226001893	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
526226001894	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
526226001895	Uncharacterized conserved protein [Function unknown]; Region: COG1262
526226001896	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
526226001897	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
526226001898	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
526226001899	substrate binding pocket [chemical binding]; other site
526226001900	catalytic triad [active]
526226001901	Secretory lipase; Region: LIP; pfam03583
526226001902	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
526226001903	FOG: WD40 repeat [General function prediction only]; Region: COG2319
526226001904	Transposase; Region: HTH_Tnp_1; cl17663
526226001905	putative transposase OrfB; Reviewed; Region: PHA02517
526226001906	HTH-like domain; Region: HTH_21; pfam13276
526226001907	Integrase core domain; Region: rve; pfam00665
526226001908	Integrase core domain; Region: rve_3; pfam13683
526226001909	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526226001910	homotrimer interaction site [polypeptide binding]; other site
526226001911	putative active site [active]
526226001912	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
526226001913	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226001914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226001915	active site
526226001916	phosphorylation site [posttranslational modification]
526226001917	intermolecular recognition site; other site
526226001918	dimerization interface [polypeptide binding]; other site
526226001919	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226001920	DNA binding site [nucleotide binding]
526226001921	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
526226001922	dimerization interface [polypeptide binding]; other site
526226001923	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226001924	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226001925	dimer interface [polypeptide binding]; other site
526226001926	phosphorylation site [posttranslational modification]
526226001927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226001928	ATP binding site [chemical binding]; other site
526226001929	Mg2+ binding site [ion binding]; other site
526226001930	G-X-G motif; other site
526226001931	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
526226001932	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
526226001933	nucleotide binding site/active site [active]
526226001934	HIT family signature motif; other site
526226001935	catalytic residue [active]
526226001936	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
526226001937	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226001938	ATP binding site [chemical binding]; other site
526226001939	putative Mg++ binding site [ion binding]; other site
526226001940	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226001941	nucleotide binding region [chemical binding]; other site
526226001942	ATP-binding site [chemical binding]; other site
526226001943	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526226001944	active site
526226001945	Predicted membrane protein [Function unknown]; Region: COG2246
526226001946	GtrA-like protein; Region: GtrA; pfam04138
526226001947	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
526226001948	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
526226001949	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
526226001950	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
526226001951	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
526226001952	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
526226001953	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
526226001954	Putative esterase; Region: Esterase; pfam00756
526226001955	Domain of unknown function DUF302; Region: DUF302; cl01364
526226001956	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
526226001957	putative homodimer interface [polypeptide binding]; other site
526226001958	putative homotetramer interface [polypeptide binding]; other site
526226001959	putative allosteric switch controlling residues; other site
526226001960	putative metal binding site [ion binding]; other site
526226001961	putative homodimer-homodimer interface [polypeptide binding]; other site
526226001962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
526226001963	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
526226001964	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
526226001965	tetramer interface [polypeptide binding]; other site
526226001966	Rdx family; Region: Rdx; cl01407
526226001967	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
526226001968	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
526226001969	ATP binding site [chemical binding]; other site
526226001970	active site
526226001971	substrate binding site [chemical binding]; other site
526226001972	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
526226001973	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526226001974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226001975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226001976	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226001977	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
526226001978	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
526226001979	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
526226001980	catalytic residues [active]
526226001981	dimer interface [polypeptide binding]; other site
526226001982	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
526226001983	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
526226001984	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
526226001985	putative active site [active]
526226001986	catalytic triad [active]
526226001987	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
526226001988	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
526226001989	active site
526226001990	metal binding site [ion binding]; metal-binding site
526226001991	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
526226001992	N-acetyl-D-glucosamine binding site [chemical binding]; other site
526226001993	Cupin; Region: Cupin_6; pfam12852
526226001994	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226001995	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526226001996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226001997	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
526226001998	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
526226001999	putative dimer interface [polypeptide binding]; other site
526226002000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226002001	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526226002002	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
526226002003	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226002004	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226002005	DNA binding residues [nucleotide binding]
526226002006	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
526226002007	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526226002008	NAD(P) binding site [chemical binding]; other site
526226002009	catalytic residues [active]
526226002010	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226002011	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226002012	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002013	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226002014	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526226002015	active site
526226002016	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526226002017	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226002018	active site
526226002019	Clp protease ATP binding subunit; Region: clpC; CHL00095
526226002020	Clp amino terminal domain; Region: Clp_N; pfam02861
526226002021	Clp amino terminal domain; Region: Clp_N; pfam02861
526226002022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226002023	Walker A motif; other site
526226002024	ATP binding site [chemical binding]; other site
526226002025	Walker B motif; other site
526226002026	arginine finger; other site
526226002027	UvrB/uvrC motif; Region: UVR; pfam02151
526226002028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226002029	Walker A motif; other site
526226002030	ATP binding site [chemical binding]; other site
526226002031	Walker B motif; other site
526226002032	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
526226002033	enoyl-CoA hydratase; Provisional; Region: PRK08260
526226002034	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226002035	substrate binding site [chemical binding]; other site
526226002036	oxyanion hole (OAH) forming residues; other site
526226002037	trimer interface [polypeptide binding]; other site
526226002038	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
526226002039	active site
526226002040	catalytic triad [active]
526226002041	oxyanion hole [active]
526226002042	Acyltransferase family; Region: Acyl_transf_3; pfam01757
526226002043	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
526226002044	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226002045	active site
526226002046	Domain of unknown function (DUF305); Region: DUF305; pfam03713
526226002047	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
526226002048	hydrophobic ligand binding site; other site
526226002049	Transmembrane secretion effector; Region: MFS_3; pfam05977
526226002050	PAS fold; Region: PAS_3; pfam08447
526226002051	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
526226002052	putative active site [active]
526226002053	heme pocket [chemical binding]; other site
526226002054	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
526226002055	TIGR03086 family protein; Region: TIGR03086
526226002056	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526226002057	Predicted transcriptional regulator [Transcription]; Region: COG2378
526226002058	HTH domain; Region: HTH_11; pfam08279
526226002059	WYL domain; Region: WYL; pfam13280
526226002060	Putative esterase; Region: Esterase; pfam00756
526226002061	S-formylglutathione hydrolase; Region: PLN02442
526226002062	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226002063	active site 2 [active]
526226002064	active site 1 [active]
526226002065	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
526226002066	metal ion-dependent adhesion site (MIDAS); other site
526226002067	MoxR-like ATPases [General function prediction only]; Region: COG0714
526226002068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226002069	Walker A motif; other site
526226002070	ATP binding site [chemical binding]; other site
526226002071	Walker B motif; other site
526226002072	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
526226002073	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226002074	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002075	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226002076	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002077	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002078	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002079	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002080	active site
526226002081	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002082	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226002083	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002084	active site
526226002085	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002086	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002087	active site
526226002088	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226002089	active site 1 [active]
526226002090	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
526226002091	DUF35 OB-fold domain; Region: DUF35; pfam01796
526226002092	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
526226002093	putative active site [active]
526226002094	putative catalytic site [active]
526226002095	lipid-transfer protein; Provisional; Region: PRK07855
526226002096	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
526226002097	active site
526226002098	acyl-CoA synthetase; Validated; Region: PRK07798
526226002099	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226002100	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226002101	active site
526226002102	CoA binding site [chemical binding]; other site
526226002103	AMP binding site [chemical binding]; other site
526226002104	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
526226002105	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
526226002106	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
526226002107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226002108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226002109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002110	enoyl-CoA hydratase; Region: PLN02864
526226002111	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
526226002112	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
526226002113	dimer interaction site [polypeptide binding]; other site
526226002114	substrate-binding tunnel; other site
526226002115	active site
526226002116	catalytic site [active]
526226002117	substrate binding site [chemical binding]; other site
526226002118	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
526226002119	L-aspartate oxidase; Provisional; Region: PRK06175
526226002120	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
526226002121	Transposase; Region: HTH_Tnp_1; pfam01527
526226002122	HTH-like domain; Region: HTH_21; pfam13276
526226002123	Integrase core domain; Region: rve; pfam00665
526226002124	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526226002125	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
526226002126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226002127	putative substrate translocation pore; other site
526226002128	Transcriptional regulators [Transcription]; Region: FadR; COG2186
526226002129	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226002130	DNA-binding site [nucleotide binding]; DNA binding site
526226002131	FCD domain; Region: FCD; pfam07729
526226002132	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226002133	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
526226002134	DNA-binding site [nucleotide binding]; DNA binding site
526226002135	FCD domain; Region: FCD; pfam07729
526226002136	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526226002137	CoA-transferase family III; Region: CoA_transf_3; pfam02515
526226002138	Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441
526226002139	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002140	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002141	active site
526226002142	enoyl-CoA hydratase; Provisional; Region: PRK05870
526226002143	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226002144	substrate binding site [chemical binding]; other site
526226002145	oxyanion hole (OAH) forming residues; other site
526226002146	trimer interface [polypeptide binding]; other site
526226002147	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
526226002148	acetaldehyde dehydrogenase; Validated; Region: PRK08300
526226002149	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
526226002150	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
526226002151	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
526226002152	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
526226002153	active site
526226002154	catalytic residues [active]
526226002155	metal binding site [ion binding]; metal-binding site
526226002156	DmpG-like communication domain; Region: DmpG_comm; pfam07836
526226002157	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
526226002158	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226002159	dimer interface [polypeptide binding]; other site
526226002160	active site
526226002161	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526226002162	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226002163	substrate binding site [chemical binding]; other site
526226002164	oxyanion hole (OAH) forming residues; other site
526226002165	trimer interface [polypeptide binding]; other site
526226002166	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
526226002167	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
526226002168	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226002169	TIGR03086 family protein; Region: TIGR03086
526226002170	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526226002171	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526226002172	NlpC/P60 family; Region: NLPC_P60; pfam00877
526226002173	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
526226002174	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
526226002175	iron-sulfur cluster [ion binding]; other site
526226002176	[2Fe-2S] cluster binding site [ion binding]; other site
526226002177	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226002178	hydrophobic ligand binding site; other site
526226002179	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002180	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
526226002181	Flavin binding site [chemical binding]; other site
526226002182	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
526226002183	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
526226002184	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
526226002185	active site
526226002186	Fe binding site [ion binding]; other site
526226002187	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
526226002188	short chain dehydrogenase; Provisional; Region: PRK07890
526226002189	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226002190	NAD(P) binding site [chemical binding]; other site
526226002191	active site
526226002192	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
526226002193	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002194	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
526226002195	active site
526226002196	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226002197	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002198	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002199	active site
526226002200	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002201	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002202	active site
526226002203	enoyl-CoA hydratase; Provisional; Region: PRK08290
526226002204	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226002205	substrate binding site [chemical binding]; other site
526226002206	oxyanion hole (OAH) forming residues; other site
526226002207	trimer interface [polypeptide binding]; other site
526226002208	Transcriptional regulator [Transcription]; Region: IclR; COG1414
526226002209	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
526226002210	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
526226002211	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
526226002212	Active Sites [active]
526226002213	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
526226002214	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
526226002215	CysD dimerization site [polypeptide binding]; other site
526226002216	G1 box; other site
526226002217	putative GEF interaction site [polypeptide binding]; other site
526226002218	GTP/Mg2+ binding site [chemical binding]; other site
526226002219	Switch I region; other site
526226002220	G2 box; other site
526226002221	G3 box; other site
526226002222	Switch II region; other site
526226002223	G4 box; other site
526226002224	G5 box; other site
526226002225	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
526226002226	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
526226002227	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
526226002228	ligand-binding site [chemical binding]; other site
526226002229	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
526226002230	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
526226002231	active site
526226002232	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
526226002233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226002234	Walker A motif; other site
526226002235	ATP binding site [chemical binding]; other site
526226002236	Walker B motif; other site
526226002237	arginine finger; other site
526226002238	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
526226002239	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
526226002240	dimerization interface [polypeptide binding]; other site
526226002241	ATP binding site [chemical binding]; other site
526226002242	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
526226002243	dimerization interface [polypeptide binding]; other site
526226002244	ATP binding site [chemical binding]; other site
526226002245	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
526226002246	active site
526226002247	catalytic site [active]
526226002248	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
526226002249	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
526226002250	amidophosphoribosyltransferase; Provisional; Region: PRK07847
526226002251	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
526226002252	active site
526226002253	tetramer interface [polypeptide binding]; other site
526226002254	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226002255	active site
526226002256	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
526226002257	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
526226002258	dimerization interface [polypeptide binding]; other site
526226002259	putative ATP binding site [chemical binding]; other site
526226002260	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
526226002261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
526226002262	MOSC domain; Region: MOSC; pfam03473
526226002263	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
526226002264	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
526226002265	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
526226002266	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
526226002267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226002268	catalytic residue [active]
526226002269	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
526226002270	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
526226002271	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
526226002272	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526226002273	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
526226002274	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
526226002275	Walker A/P-loop; other site
526226002276	ATP binding site [chemical binding]; other site
526226002277	Q-loop/lid; other site
526226002278	ABC transporter signature motif; other site
526226002279	Walker B; other site
526226002280	D-loop; other site
526226002281	H-loop/switch region; other site
526226002282	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
526226002283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226002284	Q-loop/lid; other site
526226002285	ABC transporter signature motif; other site
526226002286	Walker B; other site
526226002287	D-loop; other site
526226002288	H-loop/switch region; other site
526226002289	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
526226002290	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526226002291	NAD binding site [chemical binding]; other site
526226002292	catalytic residues [active]
526226002293	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
526226002294	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
526226002295	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226002296	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526226002297	catalytic site [active]
526226002298	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
526226002299	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526226002300	endonuclease III; Region: ENDO3c; smart00478
526226002301	minor groove reading motif; other site
526226002302	helix-hairpin-helix signature motif; other site
526226002303	substrate binding pocket [chemical binding]; other site
526226002304	active site
526226002305	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
526226002306	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
526226002307	active site clefts [active]
526226002308	zinc binding site [ion binding]; other site
526226002309	dimer interface [polypeptide binding]; other site
526226002310	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
526226002311	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
526226002312	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
526226002313	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526226002314	CoenzymeA binding site [chemical binding]; other site
526226002315	subunit interaction site [polypeptide binding]; other site
526226002316	PHB binding site; other site
526226002317	DNA repair protein RadA; Provisional; Region: PRK11823
526226002318	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526226002319	Walker A motif; other site
526226002320	ATP binding site [chemical binding]; other site
526226002321	Walker B motif; other site
526226002322	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
526226002323	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
526226002324	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
526226002325	substrate binding site; other site
526226002326	dimer interface; other site
526226002327	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
526226002328	homotrimer interaction site [polypeptide binding]; other site
526226002329	zinc binding site [ion binding]; other site
526226002330	CDP-binding sites; other site
526226002331	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
526226002332	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
526226002333	active site
526226002334	HIGH motif; other site
526226002335	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
526226002336	KMSKS motif; other site
526226002337	This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
526226002338	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
526226002339	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
526226002340	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526226002341	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
526226002342	putative active site [active]
526226002343	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
526226002344	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
526226002345	substrate binding pocket [chemical binding]; other site
526226002346	catalytic triad [active]
526226002347	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226002348	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
526226002349	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526226002350	DXD motif; other site
526226002351	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
526226002352	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
526226002353	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
526226002354	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
526226002355	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
526226002356	putative PBP binding regions; other site
526226002357	ABC-ATPase subunit  interface; other site
526226002358	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
526226002359	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
526226002360	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526226002361	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
526226002362	intersubunit interface [polypeptide binding]; other site
526226002363	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226002364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002365	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226002366	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
526226002367	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
526226002368	putative ADP-binding pocket [chemical binding]; other site
526226002369	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
526226002370	4-coumarate--CoA ligase; Region: PLN02246
526226002371	4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904
526226002372	acyl-activating enzyme (AAE) consensus motif; other site
526226002373	active site
526226002374	putative CoA binding site [chemical binding]; other site
526226002375	AMP binding site [chemical binding]; other site
526226002376	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
526226002377	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226002378	catalytic core [active]
526226002379	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226002380	Predicted acetyltransferase [General function prediction only]; Region: COG2388
526226002381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226002382	dimer interface [polypeptide binding]; other site
526226002383	phosphorylation site [posttranslational modification]
526226002384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226002385	ATP binding site [chemical binding]; other site
526226002386	G-X-G motif; other site
526226002387	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226002388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226002389	active site
526226002390	phosphorylation site [posttranslational modification]
526226002391	intermolecular recognition site; other site
526226002392	dimerization interface [polypeptide binding]; other site
526226002393	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226002394	DNA binding site [nucleotide binding]
526226002395	exopolyphosphatase; Region: exo_poly_only; TIGR03706
526226002396	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
526226002397	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
526226002398	Protein of unknown function (DUF805); Region: DUF805; pfam05656
526226002399	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526226002400	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
526226002401	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226002402	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526226002403	active site 2 [active]
526226002404	active site 1 [active]
526226002405	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
526226002406	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
526226002407	DNA binding domain, excisionase family; Region: excise; TIGR01764
526226002408	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
526226002409	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
526226002410	putative NAD(P) binding site [chemical binding]; other site
526226002411	active site
526226002412	putative substrate binding site [chemical binding]; other site
526226002413	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526226002414	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
526226002415	putative acyl-acceptor binding pocket; other site
526226002416	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526226002417	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
526226002418	putative NAD(P) binding site [chemical binding]; other site
526226002419	catalytic Zn binding site [ion binding]; other site
526226002420	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
526226002421	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
526226002422	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226002423	motif II; other site
526226002424	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
526226002425	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
526226002426	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
526226002427	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
526226002428	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
526226002429	tRNA; other site
526226002430	putative tRNA binding site [nucleotide binding]; other site
526226002431	putative NADP binding site [chemical binding]; other site
526226002432	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
526226002433	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
526226002434	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
526226002435	domain interfaces; other site
526226002436	active site
526226002437	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
526226002438	active site
526226002439	homodimer interface [polypeptide binding]; other site
526226002440	SAM binding site [chemical binding]; other site
526226002441	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
526226002442	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
526226002443	active site
526226002444	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
526226002445	dimer interface [polypeptide binding]; other site
526226002446	active site
526226002447	Schiff base residues; other site
526226002448	acyl-CoA oxidase; Region: PLN02312
526226002449	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226002450	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002451	active site
526226002452	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226002453	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002454	YcxB-like protein; Region: YcxB; pfam14317
526226002455	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002456	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
526226002457	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002458	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
526226002459	FAD binding site [chemical binding]; other site
526226002460	homotetramer interface [polypeptide binding]; other site
526226002461	substrate binding pocket [chemical binding]; other site
526226002462	catalytic base [active]
526226002463	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526226002464	putative active site [active]
526226002465	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
526226002466	active site
526226002467	catalytic triad [active]
526226002468	oxyanion hole [active]
526226002469	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
526226002470	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526226002471	inhibitor-cofactor binding pocket; inhibition site
526226002472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226002473	catalytic residue [active]
526226002474	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226002475	catalytic core [active]
526226002476	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526226002477	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526226002478	catalytic residues [active]
526226002479	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
526226002480	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
526226002481	ResB-like family; Region: ResB; pfam05140
526226002482	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
526226002483	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
526226002484	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226002485	salt bridge; other site
526226002486	non-specific DNA binding site [nucleotide binding]; other site
526226002487	sequence-specific DNA binding site [nucleotide binding]; other site
526226002488	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
526226002489	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526226002490	DNA binding residues [nucleotide binding]
526226002491	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
526226002492	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
526226002493	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
526226002494	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226002495	catalytic residue [active]
526226002496	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
526226002497	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
526226002498	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
526226002499	UbiA prenyltransferase family; Region: UbiA; pfam01040
526226002500	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
526226002501	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226002502	acyl-activating enzyme (AAE) consensus motif; other site
526226002503	AMP binding site [chemical binding]; other site
526226002504	active site
526226002505	CoA binding site [chemical binding]; other site
526226002506	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
526226002507	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
526226002508	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
526226002509	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
526226002510	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226002511	Lsr2; Region: Lsr2; pfam11774
526226002512	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
526226002513	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226002514	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
526226002515	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
526226002516	Bacterial sugar transferase; Region: Bac_transf; pfam02397
526226002517	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
526226002518	Secretory lipase; Region: LIP; pfam03583
526226002519	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
526226002520	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
526226002521	trimer interface [polypeptide binding]; other site
526226002522	active site
526226002523	substrate binding site [chemical binding]; other site
526226002524	CoA binding site [chemical binding]; other site
526226002525	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
526226002526	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
526226002527	putative active site [active]
526226002528	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226002529	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226002530	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526226002531	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226002532	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526226002533	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526226002534	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526226002535	Probable Catalytic site; other site
526226002536	metal-binding site
526226002537	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226002538	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226002539	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
526226002540	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
526226002541	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
526226002542	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
526226002543	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
526226002544	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
526226002545	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
526226002546	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
526226002547	acyl carrier protein; Provisional; Region: PRK07081
526226002548	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002549	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002550	active site
526226002551	hypothetical protein; Validated; Region: PRK07080
526226002552	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226002553	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
526226002554	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
526226002555	metal binding site [ion binding]; metal-binding site
526226002556	active site
526226002557	I-site; other site
526226002558	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
526226002559	ATP binding site [chemical binding]; other site
526226002560	substrate interface [chemical binding]; other site
526226002561	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
526226002562	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
526226002563	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226002564	substrate binding site [chemical binding]; other site
526226002565	oxyanion hole (OAH) forming residues; other site
526226002566	trimer interface [polypeptide binding]; other site
526226002567	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526226002568	CoenzymeA binding site [chemical binding]; other site
526226002569	subunit interaction site [polypeptide binding]; other site
526226002570	PHB binding site; other site
526226002571	Uncharacterized conserved protein [Function unknown]; Region: COG3268
526226002572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226002573	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
526226002574	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
526226002575	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526226002576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226002577	S-adenosylmethionine binding site [chemical binding]; other site
526226002578	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
526226002579	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
526226002580	dimer interface [polypeptide binding]; other site
526226002581	tetramer interface [polypeptide binding]; other site
526226002582	PYR/PP interface [polypeptide binding]; other site
526226002583	TPP binding site [chemical binding]; other site
526226002584	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
526226002585	TPP-binding site; other site
526226002586	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
526226002587	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
526226002588	conserved cys residue [active]
526226002589	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226002590	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
526226002591	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
526226002592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226002593	S-adenosylmethionine binding site [chemical binding]; other site
526226002594	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
526226002595	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
526226002596	conserved cys residue [active]
526226002597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226002598	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526226002599	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
526226002600	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
526226002601	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
526226002602	substrate binding pocket [chemical binding]; other site
526226002603	chain length determination region; other site
526226002604	substrate-Mg2+ binding site; other site
526226002605	catalytic residues [active]
526226002606	aspartate-rich region 1; other site
526226002607	active site lid residues [active]
526226002608	aspartate-rich region 2; other site
526226002609	heat shock protein HtpX; Provisional; Region: PRK03072
526226002610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
526226002611	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
526226002612	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
526226002613	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
526226002614	active site
526226002615	catalytic site [active]
526226002616	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226002617	active site 2 [active]
526226002618	active site 1 [active]
526226002619	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526226002620	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226002621	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226002622	active site
526226002623	ATP binding site [chemical binding]; other site
526226002624	substrate binding site [chemical binding]; other site
526226002625	activation loop (A-loop); other site
526226002626	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
526226002627	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
526226002628	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
526226002629	putative homodimer interface [polypeptide binding]; other site
526226002630	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
526226002631	heterodimer interface [polypeptide binding]; other site
526226002632	homodimer interface [polypeptide binding]; other site
526226002633	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
526226002634	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
526226002635	23S rRNA interface [nucleotide binding]; other site
526226002636	L7/L12 interface [polypeptide binding]; other site
526226002637	putative thiostrepton binding site; other site
526226002638	L25 interface [polypeptide binding]; other site
526226002639	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
526226002640	mRNA/rRNA interface [nucleotide binding]; other site
526226002641	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
526226002642	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
526226002643	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
526226002644	NAD(P) binding site [chemical binding]; other site
526226002645	LDH/MDH dimer interface [polypeptide binding]; other site
526226002646	substrate binding site [chemical binding]; other site
526226002647	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
526226002648	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
526226002649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226002650	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226002651	putative substrate translocation pore; other site
526226002652	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
526226002653	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
526226002654	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226002655	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
526226002656	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526226002657	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
526226002658	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
526226002659	23S rRNA interface [nucleotide binding]; other site
526226002660	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
526226002661	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
526226002662	L11 interface [polypeptide binding]; other site
526226002663	putative EF-Tu interaction site [polypeptide binding]; other site
526226002664	putative EF-G interaction site [polypeptide binding]; other site
526226002665	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
526226002666	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
526226002667	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
526226002668	Walker A/P-loop; other site
526226002669	ATP binding site [chemical binding]; other site
526226002670	Q-loop/lid; other site
526226002671	ABC transporter signature motif; other site
526226002672	Walker B; other site
526226002673	D-loop; other site
526226002674	H-loop/switch region; other site
526226002675	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
526226002676	Permease; Region: Permease; pfam02405
526226002677	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
526226002678	Permease; Region: Permease; pfam02405
526226002679	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226002680	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
526226002681	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
526226002682	mce related protein; Region: MCE; pfam02470
526226002683	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226002684	mce related protein; Region: MCE; pfam02470
526226002685	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226002686	mce related protein; Region: MCE; pfam02470
526226002687	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226002688	mce related protein; Region: MCE; pfam02470
526226002689	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
526226002690	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226002691	mce related protein; Region: MCE; pfam02470
526226002692	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
526226002693	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
526226002694	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
526226002695	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
526226002696	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
526226002697	RPB10 interaction site [polypeptide binding]; other site
526226002698	RPB1 interaction site [polypeptide binding]; other site
526226002699	RPB11 interaction site [polypeptide binding]; other site
526226002700	RPB3 interaction site [polypeptide binding]; other site
526226002701	RPB12 interaction site [polypeptide binding]; other site
526226002702	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
526226002703	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
526226002704	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
526226002705	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
526226002706	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
526226002707	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
526226002708	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
526226002709	G-loop; other site
526226002710	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
526226002711	DNA binding site [nucleotide binding]
526226002712	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
526226002713	MarR family; Region: MarR_2; pfam12802
526226002714	Epoxide hydrolase N terminus; Region: EHN; pfam06441
526226002715	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226002716	CoA-transferase family III; Region: CoA_transf_3; pfam02515
526226002717	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526226002718	Divergent AAA domain; Region: AAA_4; pfam04326
526226002719	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
526226002720	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226002721	Dynamin family; Region: Dynamin_N; pfam00350
526226002722	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
526226002723	G3 box; other site
526226002724	Switch II region; other site
526226002725	GTP/Mg2+ binding site [chemical binding]; other site
526226002726	G4 box; other site
526226002727	G5 box; other site
526226002728	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
526226002729	nucleotide binding site [chemical binding]; other site
526226002730	putative NEF/HSP70 interaction site [polypeptide binding]; other site
526226002731	SBD interface [polypeptide binding]; other site
526226002732	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526226002733	E3 interaction surface; other site
526226002734	lipoyl attachment site [posttranslational modification]; other site
526226002735	DNA polymerase IV; Validated; Region: PRK03352
526226002736	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
526226002737	active site
526226002738	DNA binding site [nucleotide binding]
526226002739	Lipase (class 2); Region: Lipase_2; pfam01674
526226002740	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
526226002741	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
526226002742	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
526226002743	active site
526226002744	octamer interface [polypeptide binding]; other site
526226002745	Uncharacterized conserved protein [Function unknown]; Region: COG3375
526226002746	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
526226002747	CopC domain; Region: CopC; pfam04234
526226002748	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
526226002749	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
526226002750	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
526226002751	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; cl17241
526226002752	putative transposase OrfB; Reviewed; Region: PHA02517
526226002753	HTH-like domain; Region: HTH_21; pfam13276
526226002754	Integrase core domain; Region: rve; pfam00665
526226002755	Integrase core domain; Region: rve_3; pfam13683
526226002756	Transposase; Region: HTH_Tnp_1; cl17663
526226002757	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
526226002758	putative transposase OrfB; Reviewed; Region: PHA02517
526226002759	HTH-like domain; Region: HTH_21; pfam13276
526226002760	Integrase core domain; Region: rve; pfam00665
526226002761	Integrase core domain; Region: rve_3; pfam13683
526226002762	Transposase; Region: HTH_Tnp_1; cl17663
526226002763	Transposase [DNA replication, recombination, and repair]; Region: COG5421
526226002764	Helix-turn-helix domain; Region: HTH_17; pfam12728
526226002765	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226002766	non-specific DNA binding site [nucleotide binding]; other site
526226002767	salt bridge; other site
526226002768	sequence-specific DNA binding site [nucleotide binding]; other site
526226002769	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226002770	CoA binding site [chemical binding]; other site
526226002771	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
526226002772	Int/Topo IB signature motif; other site
526226002773	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
526226002774	putative active site [active]
526226002775	putative CoA binding site [chemical binding]; other site
526226002776	nudix motif; other site
526226002777	metal binding site [ion binding]; metal-binding site
526226002778	Uncharacterized conserved protein [Function unknown]; Region: COG2353
526226002779	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526226002780	dimerization interface [polypeptide binding]; other site
526226002781	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526226002782	cyclase homology domain; Region: CHD; cd07302
526226002783	nucleotidyl binding site; other site
526226002784	metal binding site [ion binding]; metal-binding site
526226002785	dimer interface [polypeptide binding]; other site
526226002786	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
526226002787	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
526226002788	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526226002789	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226002790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226002791	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002792	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
526226002793	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226002794	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
526226002795	aminotransferase; Validated; Region: PRK07777
526226002796	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226002797	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226002798	homodimer interface [polypeptide binding]; other site
526226002799	catalytic residue [active]
526226002800	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226002801	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226002802	active site
526226002803	ATP binding site [chemical binding]; other site
526226002804	substrate binding site [chemical binding]; other site
526226002805	activation loop (A-loop); other site
526226002806	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
526226002807	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
526226002808	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226002809	nucleotide binding region [chemical binding]; other site
526226002810	ATP-binding site [chemical binding]; other site
526226002811	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526226002812	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526226002813	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226002814	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002815	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226002816	mce related protein; Region: MCE; pfam02470
526226002817	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226002818	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226002819	mce related protein; Region: MCE; pfam02470
526226002820	Permease; Region: Permease; pfam02405
526226002821	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
526226002822	WYL domain; Region: WYL; pfam13280
526226002823	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
526226002824	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
526226002825	catalytic residues [active]
526226002826	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
526226002827	trimer interface [polypeptide binding]; other site
526226002828	dimer interface [polypeptide binding]; other site
526226002829	putative active site [active]
526226002830	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
526226002831	MPT binding site; other site
526226002832	trimer interface [polypeptide binding]; other site
526226002833	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
526226002834	MoaD interaction [polypeptide binding]; other site
526226002835	active site residues [active]
526226002836	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
526226002837	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
526226002838	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226002839	FeS/SAM binding site; other site
526226002840	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
526226002841	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
526226002842	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526226002843	DNA-binding site [nucleotide binding]; DNA binding site
526226002844	RNA-binding motif; other site
526226002845	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
526226002846	H+ Antiporter protein; Region: 2A0121; TIGR00900
526226002847	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
526226002848	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002849	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002850	active site
526226002851	Hemerythrin-like domain; Region: Hr-like; cd12108
526226002852	Fe binding site [ion binding]; other site
526226002853	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
526226002854	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
526226002855	active site
526226002856	PQQ-like domain; Region: PQQ_2; pfam13360
526226002857	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226002858	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226002859	active site
526226002860	Phosphotransferase enzyme family; Region: APH; pfam01636
526226002861	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
526226002862	putative active site [active]
526226002863	putative substrate binding site [chemical binding]; other site
526226002864	ATP binding site [chemical binding]; other site
526226002865	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
526226002866	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226002867	MarR family; Region: MarR; pfam01047
526226002868	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
526226002869	hypothetical protein; Provisional; Region: PRK01346
526226002870	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
526226002871	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526226002872	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
526226002873	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526226002874	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226002875	catalytic residue [active]
526226002876	citrate synthase 2; Provisional; Region: PRK12350
526226002877	Citrate synthase; Region: Citrate_synt; pfam00285
526226002878	oxalacetate binding site [chemical binding]; other site
526226002879	citrylCoA binding site [chemical binding]; other site
526226002880	coenzyme A binding site [chemical binding]; other site
526226002881	catalytic triad [active]
526226002882	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
526226002883	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
526226002884	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
526226002885	H+ Antiporter protein; Region: 2A0121; TIGR00900
526226002886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226002887	putative substrate translocation pore; other site
526226002888	oxidase reductase; Provisional; Region: PTZ00273
526226002889	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
526226002890	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
526226002891	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526226002892	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
526226002893	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
526226002894	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
526226002895	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526226002896	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
526226002897	putative substrate binding site [chemical binding]; other site
526226002898	putative ATP binding site [chemical binding]; other site
526226002899	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
526226002900	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
526226002901	dimer interface [polypeptide binding]; other site
526226002902	active site
526226002903	citrylCoA binding site [chemical binding]; other site
526226002904	NADH binding [chemical binding]; other site
526226002905	cationic pore residues; other site
526226002906	oxalacetate/citrate binding site [chemical binding]; other site
526226002907	coenzyme A binding site [chemical binding]; other site
526226002908	catalytic triad [active]
526226002909	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
526226002910	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
526226002911	DNA photolyase; Region: DNA_photolyase; pfam00875
526226002912	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
526226002913	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
526226002914	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226002915	Walker A/P-loop; other site
526226002916	ATP binding site [chemical binding]; other site
526226002917	Q-loop/lid; other site
526226002918	ABC transporter signature motif; other site
526226002919	Walker B; other site
526226002920	D-loop; other site
526226002921	H-loop/switch region; other site
526226002922	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
526226002923	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226002924	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226002925	non-specific DNA binding site [nucleotide binding]; other site
526226002926	salt bridge; other site
526226002927	sequence-specific DNA binding site [nucleotide binding]; other site
526226002928	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226002929	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226002930	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526226002931	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226002932	substrate binding site [chemical binding]; other site
526226002933	oxyanion hole (OAH) forming residues; other site
526226002934	trimer interface [polypeptide binding]; other site
526226002935	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
526226002936	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
526226002937	FAD binding domain; Region: FAD_binding_4; pfam01565
526226002938	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
526226002939	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
526226002940	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
526226002941	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526226002942	catalytic residue [active]
526226002943	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226002944	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226002945	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526226002946	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
526226002947	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
526226002948	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226002949	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226002950	motif II; other site
526226002951	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
526226002952	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
526226002953	active site
526226002954	DNA binding site [nucleotide binding]
526226002955	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
526226002956	hydrophobic ligand binding site; other site
526226002957	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
526226002958	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526226002959	metal ion-dependent adhesion site (MIDAS); other site
526226002960	ApbE family; Region: ApbE; pfam02424
526226002961	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
526226002962	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
526226002963	FAD binding pocket [chemical binding]; other site
526226002964	conserved FAD binding motif [chemical binding]; other site
526226002965	phosphate binding motif [ion binding]; other site
526226002966	beta-alpha-beta structure motif; other site
526226002967	NAD binding pocket [chemical binding]; other site
526226002968	MOSC domain; Region: MOSC; pfam03473
526226002969	Proline dehydrogenase; Region: Pro_dh; cl03282
526226002970	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
526226002971	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
526226002972	NAD(P) binding site [chemical binding]; other site
526226002973	catalytic residues [active]
526226002974	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
526226002975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226002976	dimer interface [polypeptide binding]; other site
526226002977	conserved gate region; other site
526226002978	ABC-ATPase subunit interface; other site
526226002979	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
526226002980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226002981	dimer interface [polypeptide binding]; other site
526226002982	conserved gate region; other site
526226002983	putative PBP binding loops; other site
526226002984	ABC-ATPase subunit interface; other site
526226002985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226002986	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
526226002987	Walker A/P-loop; other site
526226002988	ATP binding site [chemical binding]; other site
526226002989	Q-loop/lid; other site
526226002990	ABC transporter signature motif; other site
526226002991	Walker B; other site
526226002992	D-loop; other site
526226002993	H-loop/switch region; other site
526226002994	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
526226002995	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226002996	motif II; other site
526226002997	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
526226002998	hydroxyglutarate oxidase; Provisional; Region: PRK11728
526226002999	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
526226003000	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526226003001	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226003002	DNA-binding site [nucleotide binding]; DNA binding site
526226003003	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
526226003004	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526226003005	Homeodomain-like domain; Region: HTH_23; pfam13384
526226003006	Winged helix-turn helix; Region: HTH_29; pfam13551
526226003007	Homeodomain-like domain; Region: HTH_32; pfam13565
526226003008	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226003009	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226003010	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
526226003011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226003012	Walker A motif; other site
526226003013	ATP binding site [chemical binding]; other site
526226003014	Walker B motif; other site
526226003015	arginine finger; other site
526226003016	Winged helix-turn helix; Region: HTH_29; pfam13551
526226003017	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
526226003018	Integrase core domain; Region: rve; pfam00665
526226003019	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
526226003020	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
526226003021	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
526226003022	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
526226003023	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226003024	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
526226003025	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
526226003026	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
526226003027	hydrophobic ligand binding site; other site
526226003028	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226003029	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226003030	Acyltransferase family; Region: Acyl_transf_3; pfam01757
526226003031	short chain dehydrogenase; Provisional; Region: PRK06179
526226003032	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
526226003033	NADP binding site [chemical binding]; other site
526226003034	active site
526226003035	steroid binding site; other site
526226003036	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
526226003037	active site
526226003038	SAM binding site [chemical binding]; other site
526226003039	homodimer interface [polypeptide binding]; other site
526226003040	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
526226003041	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
526226003042	active site
526226003043	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
526226003044	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
526226003045	putative DNA binding site [nucleotide binding]; other site
526226003046	catalytic residue [active]
526226003047	putative H2TH interface [polypeptide binding]; other site
526226003048	putative catalytic residues [active]
526226003049	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526226003050	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
526226003051	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226003052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226003053	active site
526226003054	phosphorylation site [posttranslational modification]
526226003055	intermolecular recognition site; other site
526226003056	dimerization interface [polypeptide binding]; other site
526226003057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226003058	DNA binding site [nucleotide binding]
526226003059	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226003060	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526226003061	dimerization interface [polypeptide binding]; other site
526226003062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226003063	dimer interface [polypeptide binding]; other site
526226003064	phosphorylation site [posttranslational modification]
526226003065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226003066	ATP binding site [chemical binding]; other site
526226003067	Mg2+ binding site [ion binding]; other site
526226003068	G-X-G motif; other site
526226003069	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
526226003070	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526226003071	PYR/PP interface [polypeptide binding]; other site
526226003072	dimer interface [polypeptide binding]; other site
526226003073	TPP binding site [chemical binding]; other site
526226003074	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526226003075	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
526226003076	TPP-binding site [chemical binding]; other site
526226003077	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
526226003078	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
526226003079	active site
526226003080	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
526226003081	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226003082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226003083	homodimer interface [polypeptide binding]; other site
526226003084	catalytic residue [active]
526226003085	short chain dehydrogenase; Provisional; Region: PRK08251
526226003086	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226003087	NAD(P) binding site [chemical binding]; other site
526226003088	active site
526226003089	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
526226003090	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
526226003091	active site
526226003092	dimer interface [polypeptide binding]; other site
526226003093	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
526226003094	dimer interface [polypeptide binding]; other site
526226003095	active site
526226003096	hypothetical protein; Provisional; Region: PRK07857
526226003097	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
526226003098	Part of AAA domain; Region: AAA_19; pfam13245
526226003099	Family description; Region: UvrD_C_2; pfam13538
526226003100	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226003101	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226003102	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
526226003103	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
526226003104	CoA-ligase; Region: Ligase_CoA; pfam00549
526226003105	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
526226003106	CoA binding domain; Region: CoA_binding; smart00881
526226003107	CoA-ligase; Region: Ligase_CoA; pfam00549
526226003108	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526226003109	E3 interaction surface; other site
526226003110	lipoyl attachment site [posttranslational modification]; other site
526226003111	RDD family; Region: RDD; pfam06271
526226003112	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
526226003113	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526226003114	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526226003115	nudix motif; other site
526226003116	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
526226003117	FMN binding site [chemical binding]; other site
526226003118	dimer interface [polypeptide binding]; other site
526226003119	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226003120	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226003121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526226003122	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
526226003123	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
526226003124	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
526226003125	dimer interface [polypeptide binding]; other site
526226003126	PYR/PP interface [polypeptide binding]; other site
526226003127	TPP binding site [chemical binding]; other site
526226003128	substrate binding site [chemical binding]; other site
526226003129	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
526226003130	TPP-binding site [chemical binding]; other site
526226003131	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
526226003132	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
526226003133	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
526226003134	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526226003135	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
526226003136	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
526226003137	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526226003138	carboxyltransferase (CT) interaction site; other site
526226003139	biotinylation site [posttranslational modification]; other site
526226003140	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226003141	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226003142	active site
526226003143	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
526226003144	putative active site [active]
526226003145	putative catalytic site [active]
526226003146	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
526226003147	AMP-binding domain protein; Validated; Region: PRK08315
526226003148	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226003149	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
526226003150	acyl-activating enzyme (AAE) consensus motif; other site
526226003151	putative AMP binding site [chemical binding]; other site
526226003152	putative active site [active]
526226003153	putative CoA binding site [chemical binding]; other site
526226003154	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
526226003155	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226003156	acyl-activating enzyme (AAE) consensus motif; other site
526226003157	AMP binding site [chemical binding]; other site
526226003158	active site
526226003159	CoA binding site [chemical binding]; other site
526226003160	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
526226003161	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
526226003162	active site
526226003163	substrate binding site [chemical binding]; other site
526226003164	cosubstrate binding site; other site
526226003165	catalytic site [active]
526226003166	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
526226003167	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
526226003168	purine monophosphate binding site [chemical binding]; other site
526226003169	dimer interface [polypeptide binding]; other site
526226003170	putative catalytic residues [active]
526226003171	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
526226003172	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
526226003173	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526226003174	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
526226003175	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
526226003176	active site
526226003177	non-prolyl cis peptide bond; other site
526226003178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
526226003179	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526226003180	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
526226003181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526226003182	substrate binding pocket [chemical binding]; other site
526226003183	membrane-bound complex binding site; other site
526226003184	hinge residues; other site
526226003185	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
526226003186	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
526226003187	Walker A/P-loop; other site
526226003188	ATP binding site [chemical binding]; other site
526226003189	Q-loop/lid; other site
526226003190	ABC transporter signature motif; other site
526226003191	Walker B; other site
526226003192	D-loop; other site
526226003193	H-loop/switch region; other site
526226003194	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
526226003195	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
526226003196	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
526226003197	putative hydrophobic ligand binding site [chemical binding]; other site
526226003198	TIGR03086 family protein; Region: TIGR03086
526226003199	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526226003200	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
526226003201	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
526226003202	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
526226003203	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
526226003204	metal ion-dependent adhesion site (MIDAS); other site
526226003205	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
526226003206	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
526226003207	Predicted permeases [General function prediction only]; Region: COG0679
526226003208	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
526226003209	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
526226003210	Predicted membrane protein [Function unknown]; Region: COG2860
526226003211	UPF0126 domain; Region: UPF0126; pfam03458
526226003212	UPF0126 domain; Region: UPF0126; pfam03458
526226003213	short chain dehydrogenase; Provisional; Region: PRK08267
526226003214	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226003215	NAD(P) binding site [chemical binding]; other site
526226003216	active site
526226003217	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
526226003218	ferredoxin-NADP+ reductase; Region: PLN02852
526226003219	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
526226003220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226003221	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
526226003222	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526226003223	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
526226003224	iron-sulfur cluster [ion binding]; other site
526226003225	[2Fe-2S] cluster binding site [ion binding]; other site
526226003226	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
526226003227	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
526226003228	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
526226003229	[4Fe-4S] binding site [ion binding]; other site
526226003230	molybdopterin cofactor binding site; other site
526226003231	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
526226003232	molybdopterin cofactor binding site; other site
526226003233	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
526226003234	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526226003235	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
526226003236	FAD binding pocket [chemical binding]; other site
526226003237	FAD binding motif [chemical binding]; other site
526226003238	catalytic residues [active]
526226003239	NAD binding pocket [chemical binding]; other site
526226003240	phosphate binding motif [ion binding]; other site
526226003241	beta-alpha-beta structure motif; other site
526226003242	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226003243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226003244	active site
526226003245	phosphorylation site [posttranslational modification]
526226003246	intermolecular recognition site; other site
526226003247	dimerization interface [polypeptide binding]; other site
526226003248	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226003249	DNA binding site [nucleotide binding]
526226003250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226003251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526226003252	dimerization interface [polypeptide binding]; other site
526226003253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226003254	dimer interface [polypeptide binding]; other site
526226003255	phosphorylation site [posttranslational modification]
526226003256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226003257	ATP binding site [chemical binding]; other site
526226003258	Mg2+ binding site [ion binding]; other site
526226003259	G-X-G motif; other site
526226003260	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
526226003261	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526226003262	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526226003263	protein binding site [polypeptide binding]; other site
526226003264	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
526226003265	MPT binding site; other site
526226003266	trimer interface [polypeptide binding]; other site
526226003267	MspA; Region: MspA; pfam09203
526226003268	MspA; Region: MspA; pfam09203
526226003269	putative transposase OrfB; Reviewed; Region: PHA02517
526226003270	HTH-like domain; Region: HTH_21; pfam13276
526226003271	Integrase core domain; Region: rve; pfam00665
526226003272	Integrase core domain; Region: rve_3; pfam13683
526226003273	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526226003274	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526226003275	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226003276	Walker A/P-loop; other site
526226003277	ATP binding site [chemical binding]; other site
526226003278	Q-loop/lid; other site
526226003279	ABC transporter signature motif; other site
526226003280	Walker B; other site
526226003281	D-loop; other site
526226003282	H-loop/switch region; other site
526226003283	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
526226003284	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
526226003285	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
526226003286	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
526226003287	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
526226003288	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
526226003289	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
526226003290	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
526226003291	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
526226003292	active site
526226003293	tetramer interface; other site
526226003294	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
526226003295	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
526226003296	dimer interface [polypeptide binding]; other site
526226003297	putative functional site; other site
526226003298	putative MPT binding site; other site
526226003299	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526226003300	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
526226003301	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526226003302	integrase; Provisional; Region: int; PHA02601
526226003303	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226003304	active site
526226003305	Int/Topo IB signature motif; other site
526226003306	DNA binding site [nucleotide binding]
526226003307	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526226003308	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
526226003309	catalytic residues [active]
526226003310	catalytic nucleophile [active]
526226003311	Recombinase; Region: Recombinase; pfam07508
526226003312	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
526226003313	DNA-binding interface [nucleotide binding]; DNA binding site
526226003314	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
526226003315	Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327
526226003316	Helix-turn-helix domain; Region: HTH_36; pfam13730
526226003317	Helix-turn-helix domain; Region: HTH_17; cl17695
526226003318	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526226003319	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
526226003320	catalytic residues [active]
526226003321	catalytic nucleophile [active]
526226003322	Recombinase; Region: Recombinase; pfam07508
526226003323	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
526226003324	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226003325	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226003326	salt bridge; other site
526226003327	non-specific DNA binding site [nucleotide binding]; other site
526226003328	sequence-specific DNA binding site [nucleotide binding]; other site
526226003329	Antirestriction protein (ArdA); Region: ArdA; pfam07275
526226003330	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
526226003331	DNA methylase; Region: N6_N4_Mtase; pfam01555
526226003332	Replication-relaxation; Region: Replic_Relax; pfam13814
526226003333	AAA-like domain; Region: AAA_10; pfam12846
526226003334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226003335	Walker A/P-loop; other site
526226003336	ATP binding site [chemical binding]; other site
526226003337	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
526226003338	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226003339	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526226003340	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226003341	non-specific DNA binding site [nucleotide binding]; other site
526226003342	salt bridge; other site
526226003343	sequence-specific DNA binding site [nucleotide binding]; other site
526226003344	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
526226003345	additional DNA contacts [nucleotide binding]; other site
526226003346	mismatch recognition site; other site
526226003347	active site
526226003348	zinc binding site [ion binding]; other site
526226003349	DNA intercalation site [nucleotide binding]; other site
526226003350	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
526226003351	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526226003352	cofactor binding site; other site
526226003353	DNA binding site [nucleotide binding]
526226003354	substrate interaction site [chemical binding]; other site
526226003355	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226003356	AAA domain; Region: AAA_21; pfam13304
526226003357	Walker A/P-loop; other site
526226003358	ATP binding site [chemical binding]; other site
526226003359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
526226003360	Walker B; other site
526226003361	D-loop; other site
526226003362	H-loop/switch region; other site
526226003363	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
526226003364	DNA-binding interface [nucleotide binding]; DNA binding site
526226003365	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
526226003366	beta-galactosidase; Region: BGL; TIGR03356
526226003367	AzlC protein; Region: AzlC; pfam03591
526226003368	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226003369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226003370	non-specific DNA binding site [nucleotide binding]; other site
526226003371	salt bridge; other site
526226003372	sequence-specific DNA binding site [nucleotide binding]; other site
526226003373	helicase 45; Provisional; Region: PTZ00424
526226003374	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
526226003375	ATP binding site [chemical binding]; other site
526226003376	Mg++ binding site [ion binding]; other site
526226003377	motif III; other site
526226003378	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226003379	nucleotide binding region [chemical binding]; other site
526226003380	ATP-binding site [chemical binding]; other site
526226003381	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526226003382	30S ribosomal protein S18; Provisional; Region: PRK13401
526226003383	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
526226003384	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
526226003385	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
526226003386	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
526226003387	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
526226003388	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526226003389	phosphopeptide binding site; other site
526226003390	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
526226003391	Protein kinase domain; Region: Pkinase; pfam00069
526226003392	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226003393	active site
526226003394	ATP binding site [chemical binding]; other site
526226003395	substrate binding site [chemical binding]; other site
526226003396	activation loop (A-loop); other site
526226003397	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226003398	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226003399	active site
526226003400	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
526226003401	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226003402	active site
526226003403	ATP binding site [chemical binding]; other site
526226003404	substrate binding site [chemical binding]; other site
526226003405	activation loop (A-loop); other site
526226003406	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226003407	Ligand Binding Site [chemical binding]; other site
526226003408	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226003409	Ligand Binding Site [chemical binding]; other site
526226003410	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526226003411	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
526226003412	DNA binding residues [nucleotide binding]
526226003413	hypothetical protein; Provisional; Region: PRK10279
526226003414	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
526226003415	active site
526226003416	nucleophile elbow; other site
526226003417	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
526226003418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226003419	putative substrate translocation pore; other site
526226003420	arginine deiminase; Provisional; Region: PRK01388
526226003421	Predicted transcriptional regulators [Transcription]; Region: COG1725
526226003422	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226003423	DNA-binding site [nucleotide binding]; DNA binding site
526226003424	BCCT family transporter; Region: BCCT; pfam02028
526226003425	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
526226003426	Predicted methyltransferases [General function prediction only]; Region: COG0313
526226003427	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
526226003428	putative SAM binding site [chemical binding]; other site
526226003429	putative homodimer interface [polypeptide binding]; other site
526226003430	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
526226003431	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
526226003432	chorismate binding enzyme; Region: Chorismate_bind; cl10555
526226003433	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
526226003434	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
526226003435	active site
526226003436	HIGH motif; other site
526226003437	KMSKS motif; other site
526226003438	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
526226003439	tRNA binding surface [nucleotide binding]; other site
526226003440	anticodon binding site; other site
526226003441	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526226003442	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
526226003443	DNA binding residues [nucleotide binding]
526226003444	putative dimer interface [polypeptide binding]; other site
526226003445	HEAT repeats; Region: HEAT_2; pfam13646
526226003446	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
526226003447	HEAT repeats; Region: HEAT_2; pfam13646
526226003448	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
526226003449	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
526226003450	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
526226003451	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
526226003452	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
526226003453	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226003454	motif II; other site
526226003455	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526226003456	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226003457	DNA-binding site [nucleotide binding]; DNA binding site
526226003458	FCD domain; Region: FCD; pfam07729
526226003459	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
526226003460	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526226003461	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226003462	Transposase; Region: HTH_Tnp_1; cl17663
526226003463	putative transposase OrfB; Reviewed; Region: PHA02517
526226003464	HTH-like domain; Region: HTH_21; pfam13276
526226003465	Integrase core domain; Region: rve; pfam00665
526226003466	Integrase core domain; Region: rve_3; pfam13683
526226003467	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
526226003468	mce related protein; Region: MCE; pfam02470
526226003469	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226003470	mce related protein; Region: MCE; pfam02470
526226003471	mce related protein; Region: MCE; pfam02470
526226003472	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226003473	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226003474	mce related protein; Region: MCE; pfam02470
526226003475	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226003476	mce related protein; Region: MCE; pfam02470
526226003477	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
526226003478	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
526226003479	Permease; Region: Permease; pfam02405
526226003480	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
526226003481	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
526226003482	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
526226003483	active site
526226003484	Domain of unknown function (DUF348); Region: DUF348; pfam03990
526226003485	Domain of unknown function (DUF348); Region: DUF348; pfam03990
526226003486	Domain of unknown function (DUF348); Region: DUF348; pfam03990
526226003487	G5 domain; Region: G5; pfam07501
526226003488	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
526226003489	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
526226003490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226003491	S-adenosylmethionine binding site [chemical binding]; other site
526226003492	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226003493	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526226003494	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
526226003495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226003496	motif II; other site
526226003497	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
526226003498	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
526226003499	putative molybdopterin cofactor binding site [chemical binding]; other site
526226003500	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
526226003501	putative molybdopterin cofactor binding site; other site
526226003502	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
526226003503	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
526226003504	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
526226003505	active site
526226003506	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
526226003507	Secretory lipase; Region: LIP; pfam03583
526226003508	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526226003509	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226003510	ABC transporter; Region: ABC_tran_2; pfam12848
526226003511	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226003512	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
526226003513	active site
526226003514	catalytic triad [active]
526226003515	oxyanion hole [active]
526226003516	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226003517	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226003518	active site
526226003519	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
526226003520	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226003521	dimer interface [polypeptide binding]; other site
526226003522	active site
526226003523	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226003524	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526226003525	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526226003526	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226003527	Walker A/P-loop; other site
526226003528	ATP binding site [chemical binding]; other site
526226003529	Q-loop/lid; other site
526226003530	ABC transporter signature motif; other site
526226003531	Walker B; other site
526226003532	D-loop; other site
526226003533	H-loop/switch region; other site
526226003534	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226003535	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
526226003536	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226003537	substrate binding site [chemical binding]; other site
526226003538	oxyanion hole (OAH) forming residues; other site
526226003539	trimer interface [polypeptide binding]; other site
526226003540	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
526226003541	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
526226003542	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
526226003543	G1 box; other site
526226003544	putative GEF interaction site [polypeptide binding]; other site
526226003545	GTP/Mg2+ binding site [chemical binding]; other site
526226003546	Switch I region; other site
526226003547	G2 box; other site
526226003548	G3 box; other site
526226003549	Switch II region; other site
526226003550	G4 box; other site
526226003551	G5 box; other site
526226003552	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
526226003553	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
526226003554	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
526226003555	dimer interface [polypeptide binding]; other site
526226003556	active site
526226003557	CoA binding pocket [chemical binding]; other site
526226003558	Predicted transcriptional regulators [Transcription]; Region: COG1695
526226003559	Transcriptional regulator PadR-like family; Region: PadR; cl17335
526226003560	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
526226003561	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226003562	Walker A/P-loop; other site
526226003563	ATP binding site [chemical binding]; other site
526226003564	Q-loop/lid; other site
526226003565	ABC transporter signature motif; other site
526226003566	Walker B; other site
526226003567	D-loop; other site
526226003568	H-loop/switch region; other site
526226003569	ABC-2 type transporter; Region: ABC2_membrane; cl17235
526226003570	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526226003571	PQQ-like domain; Region: PQQ_2; pfam13360
526226003572	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
526226003573	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
526226003574	dimer interface [polypeptide binding]; other site
526226003575	active site
526226003576	CoA binding pocket [chemical binding]; other site
526226003577	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
526226003578	TrkA-C domain; Region: TrkA_C; pfam02080
526226003579	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
526226003580	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
526226003581	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
526226003582	putative active site [active]
526226003583	catalytic residue [active]
526226003584	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
526226003585	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
526226003586	5S rRNA interface [nucleotide binding]; other site
526226003587	CTC domain interface [polypeptide binding]; other site
526226003588	L16 interface [polypeptide binding]; other site
526226003589	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
526226003590	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
526226003591	TM2 domain; Region: TM2; pfam05154
526226003592	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
526226003593	ArsC family; Region: ArsC; pfam03960
526226003594	catalytic residues [active]
526226003595	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
526226003596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226003597	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
526226003598	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
526226003599	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
526226003600	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226003601	active site
526226003602	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
526226003603	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
526226003604	Substrate binding site; other site
526226003605	Mg++ binding site; other site
526226003606	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
526226003607	active site
526226003608	substrate binding site [chemical binding]; other site
526226003609	CoA binding site [chemical binding]; other site
526226003610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226003611	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526226003612	NAD(P) binding site [chemical binding]; other site
526226003613	active site
526226003614	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
526226003615	putative active site [active]
526226003616	redox center [active]
526226003617	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
526226003618	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
526226003619	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
526226003620	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226003621	ABC-ATPase subunit interface; other site
526226003622	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
526226003623	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
526226003624	Walker A/P-loop; other site
526226003625	ATP binding site [chemical binding]; other site
526226003626	Q-loop/lid; other site
526226003627	ABC transporter signature motif; other site
526226003628	Walker B; other site
526226003629	D-loop; other site
526226003630	H-loop/switch region; other site
526226003631	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
526226003632	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
526226003633	SnoaL-like domain; Region: SnoaL_4; pfam13577
526226003634	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226003635	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226003636	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
526226003637	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
526226003638	putative active site [active]
526226003639	metal binding site [ion binding]; metal-binding site
526226003640	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
526226003641	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
526226003642	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226003643	ATP binding site [chemical binding]; other site
526226003644	putative Mg++ binding site [ion binding]; other site
526226003645	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226003646	nucleotide binding region [chemical binding]; other site
526226003647	ATP-binding site [chemical binding]; other site
526226003648	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
526226003649	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
526226003650	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
526226003651	homodimer interface [polypeptide binding]; other site
526226003652	metal binding site [ion binding]; metal-binding site
526226003653	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
526226003654	Sulfatase; Region: Sulfatase; cl17466
526226003655	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
526226003656	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
526226003657	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
526226003658	Active Sites [active]
526226003659	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
526226003660	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
526226003661	CysD dimerization site [polypeptide binding]; other site
526226003662	G1 box; other site
526226003663	putative GEF interaction site [polypeptide binding]; other site
526226003664	GTP/Mg2+ binding site [chemical binding]; other site
526226003665	Switch I region; other site
526226003666	G2 box; other site
526226003667	G3 box; other site
526226003668	Switch II region; other site
526226003669	G4 box; other site
526226003670	G5 box; other site
526226003671	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
526226003672	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
526226003673	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
526226003674	ligand-binding site [chemical binding]; other site
526226003675	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
526226003676	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
526226003677	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
526226003678	Imelysin; Region: Peptidase_M75; pfam09375
526226003679	Iron permease FTR1 family; Region: FTR1; cl00475
526226003680	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
526226003681	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
526226003682	N-acetyl-D-glucosamine binding site [chemical binding]; other site
526226003683	enolase; Provisional; Region: eno; PRK00077
526226003684	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
526226003685	dimer interface [polypeptide binding]; other site
526226003686	metal binding site [ion binding]; metal-binding site
526226003687	substrate binding pocket [chemical binding]; other site
526226003688	Uncharacterized conserved protein [Function unknown]; Region: COG1507
526226003689	exopolyphosphatase; Region: exo_poly_only; TIGR03706
526226003690	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
526226003691	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
526226003692	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
526226003693	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
526226003694	putative di-iron ligands [ion binding]; other site
526226003695	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
526226003696	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526226003697	FAD binding pocket [chemical binding]; other site
526226003698	FAD binding motif [chemical binding]; other site
526226003699	phosphate binding motif [ion binding]; other site
526226003700	beta-alpha-beta structure motif; other site
526226003701	NAD binding pocket [chemical binding]; other site
526226003702	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226003703	catalytic loop [active]
526226003704	iron binding site [ion binding]; other site
526226003705	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
526226003706	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226003707	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
526226003708	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
526226003709	active site
526226003710	dimer interface [polypeptide binding]; other site
526226003711	non-prolyl cis peptide bond; other site
526226003712	insertion regions; other site
526226003713	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
526226003714	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
526226003715	active site
526226003716	dimer interface [polypeptide binding]; other site
526226003717	non-prolyl cis peptide bond; other site
526226003718	insertion regions; other site
526226003719	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
526226003720	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226003721	active site
526226003722	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226003723	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226003724	active site
526226003725	ATP binding site [chemical binding]; other site
526226003726	substrate binding site [chemical binding]; other site
526226003727	activation loop (A-loop); other site
526226003728	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713
526226003729	active site
526226003730	metal binding site [ion binding]; metal-binding site
526226003731	YibE/F-like protein; Region: YibE_F; pfam07907
526226003732	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
526226003733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226003734	dimer interface [polypeptide binding]; other site
526226003735	conserved gate region; other site
526226003736	ABC-ATPase subunit interface; other site
526226003737	Transposase, Mutator family; Region: Transposase_mut; pfam00872
526226003738	MULE transposase domain; Region: MULE; pfam10551
526226003739	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
526226003740	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226003741	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226003742	Protein of unknown function (DUF664); Region: DUF664; pfam04978
526226003743	DinB superfamily; Region: DinB_2; pfam12867
526226003744	Cation efflux family; Region: Cation_efflux; cl00316
526226003745	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
526226003746	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226003747	Pirin-related protein [General function prediction only]; Region: COG1741
526226003748	Pirin; Region: Pirin; pfam02678
526226003749	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
526226003750	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226003751	Predicted esterase [General function prediction only]; Region: COG0627
526226003752	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
526226003753	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526226003754	NAD binding site [chemical binding]; other site
526226003755	catalytic residues [active]
526226003756	Uncharacterized conserved protein [Function unknown]; Region: COG1359
526226003757	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
526226003758	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
526226003759	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226003760	short chain dehydrogenase; Provisional; Region: PRK07825
526226003761	classical (c) SDRs; Region: SDR_c; cd05233
526226003762	NAD(P) binding site [chemical binding]; other site
526226003763	active site
526226003764	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
526226003765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226003766	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226003767	putative substrate translocation pore; other site
526226003768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226003769	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
526226003770	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226003771	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226003772	WHG domain; Region: WHG; pfam13305
526226003773	Bax inhibitor 1 like; Region: BaxI_1; cl17691
526226003774	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
526226003775	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226003776	dimer interface [polypeptide binding]; other site
526226003777	active site
526226003778	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
526226003779	active site
526226003780	catalytic triad [active]
526226003781	oxyanion hole [active]
526226003782	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
526226003783	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526226003784	dimer interface [polypeptide binding]; other site
526226003785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226003786	catalytic residue [active]
526226003787	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
526226003788	cystathionine gamma-synthase; Provisional; Region: PRK07811
526226003789	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
526226003790	homodimer interface [polypeptide binding]; other site
526226003791	substrate-cofactor binding pocket; other site
526226003792	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226003793	catalytic residue [active]
526226003794	threonine dehydratase; Provisional; Region: PRK08198
526226003795	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
526226003796	tetramer interface [polypeptide binding]; other site
526226003797	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226003798	catalytic residue [active]
526226003799	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
526226003800	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226003801	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
526226003802	AAA ATPase domain; Region: AAA_16; pfam13191
526226003803	NB-ARC domain; Region: NB-ARC; pfam00931
526226003804	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526226003805	ABC-2 type transporter; Region: ABC2_membrane; cl17235
526226003806	Transposase, Mutator family; Region: Transposase_mut; pfam00872
526226003807	MULE transposase domain; Region: MULE; pfam10551
526226003808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
526226003809	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
526226003810	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
526226003811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
526226003812	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
526226003813	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
526226003814	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
526226003815	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
526226003816	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
526226003817	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526226003818	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226003819	ATP binding site [chemical binding]; other site
526226003820	putative Mg++ binding site [ion binding]; other site
526226003821	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
526226003822	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
526226003823	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
526226003824	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
526226003825	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
526226003826	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
526226003827	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
526226003828	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
526226003829	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
526226003830	catalytic residues [active]
526226003831	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226003832	catalytic core [active]
526226003833	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
526226003834	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
526226003835	Amidinotransferase; Region: Amidinotransf; pfam02274
526226003836	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
526226003837	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526226003838	inhibitor-cofactor binding pocket; inhibition site
526226003839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226003840	catalytic residue [active]
526226003841	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
526226003842	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
526226003843	AsnC family; Region: AsnC_trans_reg; pfam01037
526226003844	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
526226003845	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
526226003846	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
526226003847	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
526226003848	oligomer interface [polypeptide binding]; other site
526226003849	active site residues [active]
526226003850	ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512
526226003851	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
526226003852	oligomer interface [polypeptide binding]; other site
526226003853	active site residues [active]
526226003854	PhoD-like phosphatase; Region: PhoD; pfam09423
526226003855	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
526226003856	putative active site [active]
526226003857	putative metal binding site [ion binding]; other site
526226003858	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
526226003859	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
526226003860	putative ligand binding residues [chemical binding]; other site
526226003861	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
526226003862	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526226003863	ABC-ATPase subunit  interface; other site
526226003864	dimer interface [polypeptide binding]; other site
526226003865	putative PBP binding regions; other site
526226003866	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526226003867	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
526226003868	Walker A/P-loop; other site
526226003869	ATP binding site [chemical binding]; other site
526226003870	Q-loop/lid; other site
526226003871	ABC transporter signature motif; other site
526226003872	Walker B; other site
526226003873	D-loop; other site
526226003874	H-loop/switch region; other site
526226003875	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
526226003876	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
526226003877	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
526226003878	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
526226003879	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
526226003880	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
526226003881	catalytic residue [active]
526226003882	putative FPP diphosphate  binding site; other site
526226003883	putative FPP binding hydrophobic cleft; other site
526226003884	dimer interface [polypeptide binding]; other site
526226003885	putative IPP diphosphate binding site; other site
526226003886	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226003887	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
526226003888	DNA-binding site [nucleotide binding]; DNA binding site
526226003889	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226003890	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226003891	homodimer interface [polypeptide binding]; other site
526226003892	catalytic residue [active]
526226003893	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226003894	NADH(P)-binding; Region: NAD_binding_10; pfam13460
526226003895	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
526226003896	Uncharacterized conserved protein [Function unknown]; Region: COG2128
526226003897	pantothenate kinase; Provisional; Region: PRK05439
526226003898	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
526226003899	ATP-binding site [chemical binding]; other site
526226003900	CoA-binding site [chemical binding]; other site
526226003901	Mg2+-binding site [ion binding]; other site
526226003902	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
526226003903	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
526226003904	dimer interface [polypeptide binding]; other site
526226003905	active site
526226003906	glycine-pyridoxal phosphate binding site [chemical binding]; other site
526226003907	folate binding site [chemical binding]; other site
526226003908	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
526226003909	dinuclear metal binding motif [ion binding]; other site
526226003910	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
526226003911	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
526226003912	putative active site [active]
526226003913	PhoH-like protein; Region: PhoH; pfam02562
526226003914	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226003915	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226003916	active site
526226003917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
526226003918	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
526226003919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226003920	S-adenosylmethionine binding site [chemical binding]; other site
526226003921	fumarate hydratase; Reviewed; Region: fumC; PRK00485
526226003922	Class II fumarases; Region: Fumarase_classII; cd01362
526226003923	active site
526226003924	tetramer interface [polypeptide binding]; other site
526226003925	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526226003926	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226003927	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
526226003928	putative dimerization interface [polypeptide binding]; other site
526226003929	SnoaL-like domain; Region: SnoaL_2; pfam12680
526226003930	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
526226003931	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
526226003932	putative active site [active]
526226003933	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
526226003934	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
526226003935	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
526226003936	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
526226003937	generic binding surface II; other site
526226003938	generic binding surface I; other site
526226003939	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
526226003940	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
526226003941	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
526226003942	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
526226003943	active site
526226003944	catalytic residues [active]
526226003945	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
526226003946	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
526226003947	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
526226003948	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
526226003949	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
526226003950	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
526226003951	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
526226003952	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
526226003953	23S rRNA interface [nucleotide binding]; other site
526226003954	L3 interface [polypeptide binding]; other site
526226003955	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
526226003956	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
526226003957	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
526226003958	active site
526226003959	substrate binding site [chemical binding]; other site
526226003960	metal binding site [ion binding]; metal-binding site
526226003961	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
526226003962	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226003963	motif II; other site
526226003964	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526226003965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226003966	NAD(P) binding site [chemical binding]; other site
526226003967	active site
526226003968	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226003969	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226003970	active site
526226003971	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
526226003972	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
526226003973	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
526226003974	dimerization interface [polypeptide binding]; other site
526226003975	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
526226003976	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
526226003977	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
526226003978	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
526226003979	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226003980	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
526226003981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226003982	NAD(P) binding site [chemical binding]; other site
526226003983	active site
526226003984	Uncharacterized conserved protein [Function unknown]; Region: COG3391
526226003985	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
526226003986	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
526226003987	glutaminase active site [active]
526226003988	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
526226003989	dimer interface [polypeptide binding]; other site
526226003990	active site
526226003991	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
526226003992	dimer interface [polypeptide binding]; other site
526226003993	active site
526226003994	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
526226003995	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
526226003996	putative substrate binding site [chemical binding]; other site
526226003997	putative ATP binding site [chemical binding]; other site
526226003998	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
526226003999	alanine racemase; Reviewed; Region: alr; PRK00053
526226004000	active site
526226004001	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526226004002	dimer interface [polypeptide binding]; other site
526226004003	substrate binding site [chemical binding]; other site
526226004004	catalytic residues [active]
526226004005	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226004006	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226004007	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
526226004008	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
526226004009	Glycoprotease family; Region: Peptidase_M22; pfam00814
526226004010	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
526226004011	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226004012	Coenzyme A binding pocket [chemical binding]; other site
526226004013	UGMP family protein; Validated; Region: PRK09604
526226004014	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226004015	MarR family; Region: MarR; pfam01047
526226004016	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526226004017	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226004018	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
526226004019	oligomerisation interface [polypeptide binding]; other site
526226004020	mobile loop; other site
526226004021	roof hairpin; other site
526226004022	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
526226004023	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
526226004024	ring oligomerisation interface [polypeptide binding]; other site
526226004025	ATP/Mg binding site [chemical binding]; other site
526226004026	stacking interactions; other site
526226004027	hinge regions; other site
526226004028	Transcription factor WhiB; Region: Whib; pfam02467
526226004029	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
526226004030	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226004031	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226004032	DNA binding residues [nucleotide binding]
526226004033	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
526226004034	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526226004035	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
526226004036	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
526226004037	active site
526226004038	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
526226004039	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526226004040	phosphate binding site [ion binding]; other site
526226004041	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
526226004042	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226004043	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526226004044	Cobalt transport protein; Region: CbiQ; cl00463
526226004045	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526226004046	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
526226004047	Walker A/P-loop; other site
526226004048	ATP binding site [chemical binding]; other site
526226004049	Q-loop/lid; other site
526226004050	ABC transporter signature motif; other site
526226004051	Walker B; other site
526226004052	D-loop; other site
526226004053	BioY family; Region: BioY; pfam02632
526226004054	GMP synthase; Reviewed; Region: guaA; PRK00074
526226004055	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
526226004056	AMP/PPi binding site [chemical binding]; other site
526226004057	candidate oxyanion hole; other site
526226004058	catalytic triad [active]
526226004059	potential glutamine specificity residues [chemical binding]; other site
526226004060	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
526226004061	ATP Binding subdomain [chemical binding]; other site
526226004062	Ligand Binding sites [chemical binding]; other site
526226004063	Dimerization subdomain; other site
526226004064	PspC domain; Region: PspC; cl00864
526226004065	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
526226004066	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526226004067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
526226004068	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226004069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226004070	active site
526226004071	phosphorylation site [posttranslational modification]
526226004072	intermolecular recognition site; other site
526226004073	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226004074	dimerization interface [polypeptide binding]; other site
526226004075	DNA binding residues [nucleotide binding]
526226004076	putative transposase OrfB; Reviewed; Region: PHA02517
526226004077	HTH-like domain; Region: HTH_21; pfam13276
526226004078	Integrase core domain; Region: rve; pfam00665
526226004079	Integrase core domain; Region: rve_3; pfam13683
526226004080	Transposase; Region: HTH_Tnp_1; cl17663
526226004081	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226004082	Transposase, Mutator family; Region: Transposase_mut; pfam00872
526226004083	MULE transposase domain; Region: MULE; pfam10551
526226004084	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226004085	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226004086	active site
526226004087	ATP binding site [chemical binding]; other site
526226004088	substrate binding site [chemical binding]; other site
526226004089	activation loop (A-loop); other site
526226004090	Radical SAM superfamily; Region: Radical_SAM; pfam04055
526226004091	DNA Polymerase Y-family; Region: PolY_like; cd03468
526226004092	active site
526226004093	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
526226004094	DNA binding site [nucleotide binding]
526226004095	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
526226004096	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
526226004097	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526226004098	catalytic residue [active]
526226004099	short chain dehydrogenase; Provisional; Region: PRK07201
526226004100	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
526226004101	putative NAD(P) binding site [chemical binding]; other site
526226004102	active site
526226004103	putative substrate binding site [chemical binding]; other site
526226004104	classical (c) SDRs; Region: SDR_c; cd05233
526226004105	NAD(P) binding site [chemical binding]; other site
526226004106	active site
526226004107	Protein of unknown function (DUF664); Region: DUF664; pfam04978
526226004108	DinB superfamily; Region: DinB_2; pfam12867
526226004109	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
526226004110	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
526226004111	active site
526226004112	PHP Thumb interface [polypeptide binding]; other site
526226004113	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
526226004114	generic binding surface II; other site
526226004115	generic binding surface I; other site
526226004116	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
526226004117	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
526226004118	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
526226004119	serine racemase; Region: PLN02970
526226004120	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226004121	catalytic residue [active]
526226004122	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
526226004123	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
526226004124	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
526226004125	homodimer interface [polypeptide binding]; other site
526226004126	NADP binding site [chemical binding]; other site
526226004127	substrate binding site [chemical binding]; other site
526226004128	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
526226004129	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
526226004130	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
526226004131	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
526226004132	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
526226004133	homodimer interface [polypeptide binding]; other site
526226004134	substrate-cofactor binding pocket; other site
526226004135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226004136	catalytic residue [active]
526226004137	PE-PPE domain; Region: PE-PPE; pfam08237
526226004138	Cutinase; Region: Cutinase; pfam01083
526226004139	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
526226004140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226004141	putative substrate translocation pore; other site
526226004142	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
526226004143	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
526226004144	heme binding site [chemical binding]; other site
526226004145	ferroxidase pore; other site
526226004146	ferroxidase diiron center [ion binding]; other site
526226004147	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
526226004148	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526226004149	putative catalytic site [active]
526226004150	putative metal binding site [ion binding]; other site
526226004151	putative phosphate binding site [ion binding]; other site
526226004152	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
526226004153	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
526226004154	active site
526226004155	HIGH motif; other site
526226004156	dimer interface [polypeptide binding]; other site
526226004157	KMSKS motif; other site
526226004158	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
526226004159	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
526226004160	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
526226004161	hypothetical protein; Provisional; Region: PRK06541
526226004162	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526226004163	inhibitor-cofactor binding pocket; inhibition site
526226004164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226004165	catalytic residue [active]
526226004166	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
526226004167	putative active site [active]
526226004168	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
526226004169	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
526226004170	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
526226004171	L-aspartate oxidase; Provisional; Region: PRK06175
526226004172	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
526226004173	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
526226004174	putative Iron-sulfur protein interface [polypeptide binding]; other site
526226004175	putative proximal heme binding site [chemical binding]; other site
526226004176	putative SdhC-like subunit interface [polypeptide binding]; other site
526226004177	putative distal heme binding site [chemical binding]; other site
526226004178	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
526226004179	putative Iron-sulfur protein interface [polypeptide binding]; other site
526226004180	putative proximal heme binding site [chemical binding]; other site
526226004181	putative SdhD-like interface [polypeptide binding]; other site
526226004182	putative distal heme binding site [chemical binding]; other site
526226004183	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
526226004184	active site
526226004185	catalytic motif [active]
526226004186	Zn binding site [ion binding]; other site
526226004187	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
526226004188	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
526226004189	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
526226004190	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
526226004191	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
526226004192	adenosine deaminase; Provisional; Region: PRK09358
526226004193	active site
526226004194	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526226004195	NlpC/P60 family; Region: NLPC_P60; pfam00877
526226004196	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226004197	active site
526226004198	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526226004199	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226004200	Walker A/P-loop; other site
526226004201	ATP binding site [chemical binding]; other site
526226004202	Q-loop/lid; other site
526226004203	ABC transporter signature motif; other site
526226004204	Walker B; other site
526226004205	D-loop; other site
526226004206	H-loop/switch region; other site
526226004207	purine nucleoside phosphorylase; Provisional; Region: PRK08202
526226004208	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226004209	substrate binding site [chemical binding]; other site
526226004210	oxyanion hole (OAH) forming residues; other site
526226004211	trimer interface [polypeptide binding]; other site
526226004212	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
526226004213	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
526226004214	metal binding site [ion binding]; metal-binding site
526226004215	putative dimer interface [polypeptide binding]; other site
526226004216	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
526226004217	putative active site pocket [active]
526226004218	dimerization interface [polypeptide binding]; other site
526226004219	putative catalytic residue [active]
526226004220	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
526226004221	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226004222	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526226004223	Transposase [DNA replication, recombination, and repair]; Region: COG5421
526226004224	glycerol kinase; Provisional; Region: glpK; PRK00047
526226004225	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
526226004226	N- and C-terminal domain interface [polypeptide binding]; other site
526226004227	active site
526226004228	MgATP binding site [chemical binding]; other site
526226004229	catalytic site [active]
526226004230	metal binding site [ion binding]; metal-binding site
526226004231	putative homotetramer interface [polypeptide binding]; other site
526226004232	glycerol binding site [chemical binding]; other site
526226004233	homodimer interface [polypeptide binding]; other site
526226004234	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
526226004235	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
526226004236	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
526226004237	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
526226004238	putative DNA binding site [nucleotide binding]; other site
526226004239	catalytic residue [active]
526226004240	putative H2TH interface [polypeptide binding]; other site
526226004241	putative catalytic residues [active]
526226004242	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526226004243	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226004244	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
526226004245	ATP binding site [chemical binding]; other site
526226004246	putative Mg++ binding site [ion binding]; other site
526226004247	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226004248	nucleotide binding region [chemical binding]; other site
526226004249	ATP-binding site [chemical binding]; other site
526226004250	DEAD/H associated; Region: DEAD_assoc; pfam08494
526226004251	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
526226004252	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
526226004253	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
526226004254	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226004255	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226004256	active site
526226004257	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
526226004258	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
526226004259	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526226004260	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526226004261	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
526226004262	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526226004263	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526226004264	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
526226004265	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
526226004266	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
526226004267	active site
526226004268	putative substrate binding pocket [chemical binding]; other site
526226004269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226004270	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526226004271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226004272	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226004273	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226004274	non-specific DNA binding site [nucleotide binding]; other site
526226004275	salt bridge; other site
526226004276	sequence-specific DNA binding site [nucleotide binding]; other site
526226004277	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
526226004278	Domain of unknown function (DUF955); Region: DUF955; pfam06114
526226004279	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
526226004280	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
526226004281	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
526226004282	tetramer interface [polypeptide binding]; other site
526226004283	active site
526226004284	Mg2+/Mn2+ binding site [ion binding]; other site
526226004285	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
526226004286	oxalacetate binding site [chemical binding]; other site
526226004287	citrylCoA binding site [chemical binding]; other site
526226004288	coenzyme A binding site [chemical binding]; other site
526226004289	catalytic triad [active]
526226004290	pyruvate carboxylase; Reviewed; Region: PRK12999
526226004291	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526226004292	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526226004293	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
526226004294	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
526226004295	active site
526226004296	catalytic residues [active]
526226004297	metal binding site [ion binding]; metal-binding site
526226004298	homodimer binding site [polypeptide binding]; other site
526226004299	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526226004300	carboxyltransferase (CT) interaction site; other site
526226004301	biotinylation site [posttranslational modification]; other site
526226004302	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
526226004303	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
526226004304	active site
526226004305	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
526226004306	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
526226004307	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
526226004308	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226004309	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526226004310	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226004311	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
526226004312	active site
526226004313	homotetramer interface [polypeptide binding]; other site
526226004314	putative OHCU decarboxylase; Provisional; Region: PRK13798
526226004315	xanthine permease; Region: pbuX; TIGR03173
526226004316	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
526226004317	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
526226004318	Ligand binding site; other site
526226004319	metal-binding site
526226004320	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226004321	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226004322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226004323	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226004324	putative substrate translocation pore; other site
526226004325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226004326	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
526226004327	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526226004328	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
526226004329	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
526226004330	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526226004331	carboxyltransferase (CT) interaction site; other site
526226004332	biotinylation site [posttranslational modification]; other site
526226004333	Condensation domain; Region: Condensation; pfam00668
526226004334	Fe-S metabolism associated domain; Region: SufE; cl00951
526226004335	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
526226004336	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
526226004337	active site residue [active]
526226004338	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
526226004339	active site residue [active]
526226004340	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
526226004341	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
526226004342	Maf-like protein; Region: Maf; pfam02545
526226004343	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
526226004344	active site
526226004345	dimer interface [polypeptide binding]; other site
526226004346	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
526226004347	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
526226004348	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
526226004349	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526226004350	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
526226004351	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
526226004352	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
526226004353	Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712
526226004354	Bacterial PH domain; Region: DUF304; pfam03703
526226004355	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226004356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226004357	active site
526226004358	phosphorylation site [posttranslational modification]
526226004359	intermolecular recognition site; other site
526226004360	dimerization interface [polypeptide binding]; other site
526226004361	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226004362	DNA binding site [nucleotide binding]
526226004363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226004364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
526226004365	dimer interface [polypeptide binding]; other site
526226004366	phosphorylation site [posttranslational modification]
526226004367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226004368	ATP binding site [chemical binding]; other site
526226004369	Mg2+ binding site [ion binding]; other site
526226004370	G-X-G motif; other site
526226004371	Predicted membrane protein [Function unknown]; Region: COG2246
526226004372	GtrA-like protein; Region: GtrA; pfam04138
526226004373	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
526226004374	ATP-grasp domain; Region: ATP-grasp; pfam02222
526226004375	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
526226004376	Homeodomain-like domain; Region: HTH_23; pfam13384
526226004377	Winged helix-turn helix; Region: HTH_29; pfam13551
526226004378	Homeodomain-like domain; Region: HTH_32; pfam13565
526226004379	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226004380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226004381	Domain of unknown function (DUF385); Region: DUF385; cl04387
526226004382	TIGR03089 family protein; Region: TIGR03089
526226004383	Transcriptional regulator [Transcription]; Region: LytR; COG1316
526226004384	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526226004385	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
526226004386	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
526226004387	NADP binding site [chemical binding]; other site
526226004388	active site
526226004389	putative substrate binding site [chemical binding]; other site
526226004390	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526226004391	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526226004392	Probable Catalytic site; other site
526226004393	metal-binding site
526226004394	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
526226004395	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
526226004396	active site
526226004397	Substrate binding site; other site
526226004398	Mg++ binding site; other site
526226004399	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
526226004400	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
526226004401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226004402	S-adenosylmethionine binding site [chemical binding]; other site
526226004403	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
526226004404	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226004405	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226004406	DNA binding residues [nucleotide binding]
526226004407	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526226004408	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526226004409	protein binding site [polypeptide binding]; other site
526226004410	sec-independent translocase; Provisional; Region: tatB; PRK00182
526226004411	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
526226004412	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
526226004413	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
526226004414	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
526226004415	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
526226004416	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
526226004417	N-acetyl-D-glucosamine binding site [chemical binding]; other site
526226004418	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
526226004419	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
526226004420	PRC-barrel domain; Region: PRC; pfam05239
526226004421	MgtE intracellular N domain; Region: MgtE_N; smart00924
526226004422	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
526226004423	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
526226004424	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
526226004425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226004426	dimer interface [polypeptide binding]; other site
526226004427	conserved gate region; other site
526226004428	putative PBP binding loops; other site
526226004429	ABC-ATPase subunit interface; other site
526226004430	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
526226004431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226004432	dimer interface [polypeptide binding]; other site
526226004433	conserved gate region; other site
526226004434	putative PBP binding loops; other site
526226004435	ABC-ATPase subunit interface; other site
526226004436	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
526226004437	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
526226004438	Walker A/P-loop; other site
526226004439	ATP binding site [chemical binding]; other site
526226004440	Q-loop/lid; other site
526226004441	ABC transporter signature motif; other site
526226004442	Walker B; other site
526226004443	D-loop; other site
526226004444	H-loop/switch region; other site
526226004445	TOBE domain; Region: TOBE; pfam03459
526226004446	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526226004447	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526226004448	active site
526226004449	metal binding site [ion binding]; metal-binding site
526226004450	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
526226004451	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
526226004452	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
526226004453	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
526226004454	oligomer interface [polypeptide binding]; other site
526226004455	metal binding site [ion binding]; metal-binding site
526226004456	metal binding site [ion binding]; metal-binding site
526226004457	putative Cl binding site [ion binding]; other site
526226004458	basic sphincter; other site
526226004459	hydrophobic gate; other site
526226004460	periplasmic entrance; other site
526226004461	MarC family integral membrane protein; Region: MarC; cl00919
526226004462	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
526226004463	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
526226004464	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
526226004465	short chain dehydrogenase; Provisional; Region: PRK07832
526226004466	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226004467	NAD(P) binding site [chemical binding]; other site
526226004468	active site
526226004469	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226004470	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226004471	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
526226004472	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226004473	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
526226004474	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
526226004475	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
526226004476	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
526226004477	TPP-binding site [chemical binding]; other site
526226004478	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
526226004479	dimer interface [polypeptide binding]; other site
526226004480	PYR/PP interface [polypeptide binding]; other site
526226004481	TPP binding site [chemical binding]; other site
526226004482	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526226004483	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526226004484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226004485	Walker A/P-loop; other site
526226004486	ATP binding site [chemical binding]; other site
526226004487	Q-loop/lid; other site
526226004488	ABC transporter signature motif; other site
526226004489	Walker B; other site
526226004490	D-loop; other site
526226004491	H-loop/switch region; other site
526226004492	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526226004493	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526226004494	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226004495	Walker A/P-loop; other site
526226004496	ATP binding site [chemical binding]; other site
526226004497	Q-loop/lid; other site
526226004498	ABC transporter signature motif; other site
526226004499	Walker B; other site
526226004500	D-loop; other site
526226004501	H-loop/switch region; other site
526226004502	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
526226004503	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
526226004504	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
526226004505	putative dimer interface [polypeptide binding]; other site
526226004506	N-terminal domain interface [polypeptide binding]; other site
526226004507	putative substrate binding pocket (H-site) [chemical binding]; other site
526226004508	Predicted transcriptional regulators [Transcription]; Region: COG1695
526226004509	Transcriptional regulator PadR-like family; Region: PadR; cl17335
526226004510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226004511	putative substrate translocation pore; other site
526226004512	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226004513	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
526226004514	active site
526226004515	metal binding site [ion binding]; metal-binding site
526226004516	DNA binding site [nucleotide binding]
526226004517	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
526226004518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226004519	AAA domain; Region: AAA_23; pfam13476
526226004520	Walker A/P-loop; other site
526226004521	ATP binding site [chemical binding]; other site
526226004522	Q-loop/lid; other site
526226004523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226004524	ABC transporter signature motif; other site
526226004525	Walker B; other site
526226004526	D-loop; other site
526226004527	H-loop/switch region; other site
526226004528	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
526226004529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226004530	Walker A motif; other site
526226004531	ATP binding site [chemical binding]; other site
526226004532	Walker B motif; other site
526226004533	arginine finger; other site
526226004534	Winged helix-turn helix; Region: HTH_29; pfam13551
526226004535	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
526226004536	Integrase core domain; Region: rve; pfam00665
526226004537	putative transposase OrfB; Reviewed; Region: PHA02517
526226004538	HTH-like domain; Region: HTH_21; pfam13276
526226004539	Integrase core domain; Region: rve; pfam00665
526226004540	Integrase core domain; Region: rve_3; pfam13683
526226004541	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226004542	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226004543	active site
526226004544	Domain of unknown function (DUF305); Region: DUF305; pfam03713
526226004545	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
526226004546	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
526226004547	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
526226004548	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
526226004549	active site
526226004550	HIGH motif; other site
526226004551	KMSK motif region; other site
526226004552	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
526226004553	tRNA binding surface [nucleotide binding]; other site
526226004554	anticodon binding site; other site
526226004555	diaminopimelate decarboxylase; Region: lysA; TIGR01048
526226004556	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
526226004557	active site
526226004558	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526226004559	substrate binding site [chemical binding]; other site
526226004560	catalytic residues [active]
526226004561	dimer interface [polypeptide binding]; other site
526226004562	homoserine dehydrogenase; Provisional; Region: PRK06349
526226004563	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
526226004564	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
526226004565	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
526226004566	threonine synthase; Reviewed; Region: PRK06721
526226004567	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
526226004568	homodimer interface [polypeptide binding]; other site
526226004569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226004570	catalytic residue [active]
526226004571	homoserine kinase; Provisional; Region: PRK01212
526226004572	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
526226004573	transcription termination factor Rho; Provisional; Region: PRK12608
526226004574	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526226004575	RNA binding site [nucleotide binding]; other site
526226004576	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
526226004577	multimer interface [polypeptide binding]; other site
526226004578	Walker A motif; other site
526226004579	ATP binding site [chemical binding]; other site
526226004580	Walker B motif; other site
526226004581	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
526226004582	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
526226004583	Flavodoxin; Region: Flavodoxin_1; pfam00258
526226004584	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
526226004585	FAD binding pocket [chemical binding]; other site
526226004586	FAD binding motif [chemical binding]; other site
526226004587	catalytic residues [active]
526226004588	NAD binding pocket [chemical binding]; other site
526226004589	phosphate binding motif [ion binding]; other site
526226004590	beta-alpha-beta structure motif; other site
526226004591	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
526226004592	peptide chain release factor 1; Validated; Region: prfA; PRK00591
526226004593	This domain is found in peptide chain release factors; Region: PCRF; smart00937
526226004594	RF-1 domain; Region: RF-1; pfam00472
526226004595	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
526226004596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226004597	S-adenosylmethionine binding site [chemical binding]; other site
526226004598	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
526226004599	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526226004600	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
526226004601	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226004602	catalytic residue [active]
526226004603	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
526226004604	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
526226004605	Mg++ binding site [ion binding]; other site
526226004606	putative catalytic motif [active]
526226004607	substrate binding site [chemical binding]; other site
526226004608	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
526226004609	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
526226004610	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
526226004611	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
526226004612	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
526226004613	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
526226004614	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
526226004615	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
526226004616	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
526226004617	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
526226004618	beta subunit interaction interface [polypeptide binding]; other site
526226004619	Walker A motif; other site
526226004620	ATP binding site [chemical binding]; other site
526226004621	Walker B motif; other site
526226004622	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
526226004623	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
526226004624	core domain interface [polypeptide binding]; other site
526226004625	delta subunit interface [polypeptide binding]; other site
526226004626	epsilon subunit interface [polypeptide binding]; other site
526226004627	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
526226004628	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
526226004629	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
526226004630	alpha subunit interaction interface [polypeptide binding]; other site
526226004631	Walker A motif; other site
526226004632	ATP binding site [chemical binding]; other site
526226004633	Walker B motif; other site
526226004634	inhibitor binding site; inhibition site
526226004635	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
526226004636	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
526226004637	gamma subunit interface [polypeptide binding]; other site
526226004638	LBP interface [polypeptide binding]; other site
526226004639	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
526226004640	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
526226004641	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
526226004642	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
526226004643	hinge; other site
526226004644	active site
526226004645	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226004646	dimerization interface [polypeptide binding]; other site
526226004647	putative DNA binding site [nucleotide binding]; other site
526226004648	putative Zn2+ binding site [ion binding]; other site
526226004649	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310
526226004650	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
526226004651	PDGLE domain; Region: PDGLE; pfam13190
526226004652	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
526226004653	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
526226004654	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
526226004655	Walker A/P-loop; other site
526226004656	ATP binding site [chemical binding]; other site
526226004657	Q-loop/lid; other site
526226004658	ABC transporter signature motif; other site
526226004659	Walker B; other site
526226004660	D-loop; other site
526226004661	H-loop/switch region; other site
526226004662	NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266
526226004663	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
526226004664	active site
526226004665	NAD binding site [chemical binding]; other site
526226004666	metal binding site [ion binding]; metal-binding site
526226004667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226004668	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
526226004669	Walker A motif; other site
526226004670	ATP binding site [chemical binding]; other site
526226004671	Walker B motif; other site
526226004672	arginine finger; other site
526226004673	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
526226004674	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
526226004675	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
526226004676	active site
526226004677	NAD binding site [chemical binding]; other site
526226004678	metal binding site [ion binding]; metal-binding site
526226004679	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526226004680	Histidine kinase; Region: HisKA_3; pfam07730
526226004681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226004682	ATP binding site [chemical binding]; other site
526226004683	Mg2+ binding site [ion binding]; other site
526226004684	G-X-G motif; other site
526226004685	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226004686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226004687	active site
526226004688	phosphorylation site [posttranslational modification]
526226004689	intermolecular recognition site; other site
526226004690	dimerization interface [polypeptide binding]; other site
526226004691	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226004692	DNA binding residues [nucleotide binding]
526226004693	dimerization interface [polypeptide binding]; other site
526226004694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226004695	S-adenosylmethionine binding site [chemical binding]; other site
526226004696	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226004697	Ligand Binding Site [chemical binding]; other site
526226004698	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226004699	Ligand Binding Site [chemical binding]; other site
526226004700	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
526226004701	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
526226004702	putative ligand binding site [chemical binding]; other site
526226004703	MarR family; Region: MarR_2; cl17246
526226004704	MoxR-like ATPases [General function prediction only]; Region: COG0714
526226004705	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226004706	Walker A motif; other site
526226004707	ATP binding site [chemical binding]; other site
526226004708	Walker B motif; other site
526226004709	arginine finger; other site
526226004710	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
526226004711	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
526226004712	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
526226004713	multimer interface [polypeptide binding]; other site
526226004714	active site
526226004715	catalytic triad [active]
526226004716	dimer interface [polypeptide binding]; other site
526226004717	SnoaL-like domain; Region: SnoaL_2; pfam12680
526226004718	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226004719	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226004720	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
526226004721	glutaminase; Provisional; Region: PRK00971
526226004722	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
526226004723	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
526226004724	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
526226004725	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
526226004726	homodimer interface [polypeptide binding]; other site
526226004727	putative substrate binding pocket [chemical binding]; other site
526226004728	diiron center [ion binding]; other site
526226004729	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
526226004730	hypothetical protein; Provisional; Region: PRK03298
526226004731	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
526226004732	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226004733	dimer interface [polypeptide binding]; other site
526226004734	substrate binding site [chemical binding]; other site
526226004735	metal binding site [ion binding]; metal-binding site
526226004736	putative acyltransferase; Provisional; Region: PRK05790
526226004737	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226004738	dimer interface [polypeptide binding]; other site
526226004739	active site
526226004740	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
526226004741	Domain of unknown function DUF77; Region: DUF77; pfam01910
526226004742	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
526226004743	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
526226004744	glycogen branching enzyme; Provisional; Region: PRK05402
526226004745	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
526226004746	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
526226004747	active site
526226004748	catalytic site [active]
526226004749	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
526226004750	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
526226004751	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
526226004752	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
526226004753	active site
526226004754	catalytic site [active]
526226004755	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
526226004756	DEAD/DEAH box helicase; Region: DEAD; pfam00270
526226004757	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226004758	putative Mg++ binding site [ion binding]; other site
526226004759	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
526226004760	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
526226004761	Isochorismatase family; Region: Isochorismatase; pfam00857
526226004762	catalytic triad [active]
526226004763	conserved cis-peptide bond; other site
526226004764	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
526226004765	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
526226004766	active site
526226004767	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
526226004768	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
526226004769	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
526226004770	putative active site pocket [active]
526226004771	cleavage site
526226004772	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526226004773	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
526226004774	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
526226004775	MPN+ (JAMM) motif; other site
526226004776	Zinc-binding site [ion binding]; other site
526226004777	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
526226004778	MoaE interaction surface [polypeptide binding]; other site
526226004779	MoeB interaction surface [polypeptide binding]; other site
526226004780	thiocarboxylated glycine; other site
526226004781	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
526226004782	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526226004783	dimer interface [polypeptide binding]; other site
526226004784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226004785	catalytic residue [active]
526226004786	Rhomboid family; Region: Rhomboid; pfam01694
526226004787	glutamate racemase; Provisional; Region: PRK00865
526226004788	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
526226004789	ribonuclease PH; Reviewed; Region: rph; PRK00173
526226004790	Ribonuclease PH; Region: RNase_PH_bact; cd11362
526226004791	hexamer interface [polypeptide binding]; other site
526226004792	active site
526226004793	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
526226004794	active site
526226004795	dimerization interface [polypeptide binding]; other site
526226004796	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226004797	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
526226004798	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
526226004799	Glucitol operon activator protein (GutM); Region: GutM; cl01890
526226004800	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526226004801	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526226004802	DNA interaction; other site
526226004803	Metal-binding active site; metal-binding site
526226004804	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
526226004805	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526226004806	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226004807	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526226004808	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526226004809	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226004810	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526226004811	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526226004812	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526226004813	DNA binding site [nucleotide binding]
526226004814	domain linker motif; other site
526226004815	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526226004816	dimerization interface [polypeptide binding]; other site
526226004817	ligand binding site [chemical binding]; other site
526226004818	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
526226004819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226004820	S-adenosylmethionine binding site [chemical binding]; other site
526226004821	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
526226004822	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526226004823	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226004824	catalytic residue [active]
526226004825	OpgC protein; Region: OpgC_C; cl17858
526226004826	Acyltransferase family; Region: Acyl_transf_3; pfam01757
526226004827	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
526226004828	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
526226004829	acyl-activating enzyme (AAE) consensus motif; other site
526226004830	putative AMP binding site [chemical binding]; other site
526226004831	putative active site [active]
526226004832	putative CoA binding site [chemical binding]; other site
526226004833	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
526226004834	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
526226004835	ATP binding site [chemical binding]; other site
526226004836	Mg++ binding site [ion binding]; other site
526226004837	motif III; other site
526226004838	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226004839	nucleotide binding region [chemical binding]; other site
526226004840	ATP-binding site [chemical binding]; other site
526226004841	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
526226004842	putative RNA binding site [nucleotide binding]; other site
526226004843	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
526226004844	Part of AAA domain; Region: AAA_19; pfam13245
526226004845	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
526226004846	AAA domain; Region: AAA_12; pfam13087
526226004847	NAD-dependent deacetylase; Provisional; Region: PRK00481
526226004848	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
526226004849	NAD+ binding site [chemical binding]; other site
526226004850	substrate binding site [chemical binding]; other site
526226004851	Zn binding site [ion binding]; other site
526226004852	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
526226004853	HIT family signature motif; other site
526226004854	catalytic residue [active]
526226004855	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
526226004856	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
526226004857	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
526226004858	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226004859	active site 2 [active]
526226004860	active site 1 [active]
526226004861	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
526226004862	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
526226004863	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
526226004864	putative NAD(P) binding site [chemical binding]; other site
526226004865	active site
526226004866	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
526226004867	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
526226004868	active site
526226004869	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
526226004870	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226004871	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226004872	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
526226004873	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
526226004874	catalytic triad [active]
526226004875	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
526226004876	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
526226004877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
526226004878	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
526226004879	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526226004880	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
526226004881	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
526226004882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
526226004883	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526226004884	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226004885	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226004886	active site
526226004887	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
526226004888	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
526226004889	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226004890	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226004891	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
526226004892	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226004893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
526226004894	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226004895	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
526226004896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226004897	putative substrate translocation pore; other site
526226004898	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
526226004899	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226004900	DNA binding residues [nucleotide binding]
526226004901	YCII-related domain; Region: YCII; cl00999
526226004902	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
526226004903	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
526226004904	catalytic site [active]
526226004905	putative active site [active]
526226004906	putative substrate binding site [chemical binding]; other site
526226004907	dimer interface [polypeptide binding]; other site
526226004908	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
526226004909	Domain of unknown function DUF87; Region: DUF87; pfam01935
526226004910	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
526226004911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226004912	NAD(P) binding site [chemical binding]; other site
526226004913	active site
526226004914	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
526226004915	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
526226004916	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
526226004917	active site
526226004918	FMN binding site [chemical binding]; other site
526226004919	2,4-decadienoyl-CoA binding site; other site
526226004920	catalytic residue [active]
526226004921	4Fe-4S cluster binding site [ion binding]; other site
526226004922	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
526226004923	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226004924	Predicted transcriptional regulators [Transcription]; Region: COG1695
526226004925	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
526226004926	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
526226004927	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
526226004928	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
526226004929	heme-binding site [chemical binding]; other site
526226004930	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
526226004931	FAD binding pocket [chemical binding]; other site
526226004932	FAD binding motif [chemical binding]; other site
526226004933	phosphate binding motif [ion binding]; other site
526226004934	beta-alpha-beta structure motif; other site
526226004935	NAD binding pocket [chemical binding]; other site
526226004936	Predicted transcriptional regulator [Transcription]; Region: COG1959
526226004937	Transcriptional regulator; Region: Rrf2; cl17282
526226004938	MgtE intracellular N domain; Region: MgtE_N; cl15244
526226004939	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
526226004940	Copper resistance protein D; Region: CopD; cl00563
526226004941	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
526226004942	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
526226004943	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526226004944	dimer interface [polypeptide binding]; other site
526226004945	ssDNA binding site [nucleotide binding]; other site
526226004946	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526226004947	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
526226004948	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226004949	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226004950	ABC transporter; Region: ABC_tran_2; pfam12848
526226004951	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226004952	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
526226004953	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
526226004954	active site
526226004955	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
526226004956	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
526226004957	active site
526226004958	catalytic site [active]
526226004959	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
526226004960	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
526226004961	apolar tunnel; other site
526226004962	heme binding site [chemical binding]; other site
526226004963	dimerization interface [polypeptide binding]; other site
526226004964	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
526226004965	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226004966	active site
526226004967	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
526226004968	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
526226004969	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
526226004970	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226004971	ATP binding site [chemical binding]; other site
526226004972	Mg2+ binding site [ion binding]; other site
526226004973	G-X-G motif; other site
526226004974	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
526226004975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226004976	active site
526226004977	phosphorylation site [posttranslational modification]
526226004978	intermolecular recognition site; other site
526226004979	dimerization interface [polypeptide binding]; other site
526226004980	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
526226004981	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
526226004982	Zn binding site [ion binding]; other site
526226004983	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
526226004984	catalytic residues [active]
526226004985	Peptidase family M48; Region: Peptidase_M48; pfam01435
526226004986	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
526226004987	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
526226004988	DNA binding site [nucleotide binding]
526226004989	catalytic residue [active]
526226004990	H2TH interface [polypeptide binding]; other site
526226004991	putative catalytic residues [active]
526226004992	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
526226004993	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526226004994	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
526226004995	PE-PPE domain; Region: PE-PPE; pfam08237
526226004996	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526226004997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
526226004998	Secretory lipase; Region: LIP; pfam03583
526226004999	trigger factor; Provisional; Region: tig; PRK01490
526226005000	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
526226005001	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
526226005002	Clp protease; Region: CLP_protease; pfam00574
526226005003	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
526226005004	oligomer interface [polypeptide binding]; other site
526226005005	active site residues [active]
526226005006	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
526226005007	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
526226005008	oligomer interface [polypeptide binding]; other site
526226005009	active site residues [active]
526226005010	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
526226005011	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
526226005012	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226005013	Walker A motif; other site
526226005014	ATP binding site [chemical binding]; other site
526226005015	Walker B motif; other site
526226005016	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
526226005017	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
526226005018	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
526226005019	GTP binding site; other site
526226005020	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
526226005021	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526226005022	active site
526226005023	HIGH motif; other site
526226005024	nucleotide binding site [chemical binding]; other site
526226005025	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
526226005026	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
526226005027	active site
526226005028	KMSKS motif; other site
526226005029	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
526226005030	tRNA binding surface [nucleotide binding]; other site
526226005031	anticodon binding site; other site
526226005032	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
526226005033	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
526226005034	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526226005035	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526226005036	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
526226005037	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
526226005038	active site
526226005039	multimer interface [polypeptide binding]; other site
526226005040	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
526226005041	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
526226005042	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
526226005043	homodimer interface [polypeptide binding]; other site
526226005044	oligonucleotide binding site [chemical binding]; other site
526226005045	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
526226005046	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
526226005047	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
526226005048	GTPase CgtA; Reviewed; Region: obgE; PRK12296
526226005049	GTP1/OBG; Region: GTP1_OBG; pfam01018
526226005050	Obg GTPase; Region: Obg; cd01898
526226005051	G1 box; other site
526226005052	GTP/Mg2+ binding site [chemical binding]; other site
526226005053	Switch I region; other site
526226005054	G2 box; other site
526226005055	G3 box; other site
526226005056	Switch II region; other site
526226005057	G4 box; other site
526226005058	G5 box; other site
526226005059	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
526226005060	gamma-glutamyl kinase; Provisional; Region: PRK05429
526226005061	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
526226005062	nucleotide binding site [chemical binding]; other site
526226005063	substrate binding site [chemical binding]; other site
526226005064	PUA domain; Region: PUA; pfam01472
526226005065	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
526226005066	NAD-dependent deacetylase; Provisional; Region: PRK00481
526226005067	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
526226005068	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
526226005069	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526226005070	inhibitor-cofactor binding pocket; inhibition site
526226005071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226005072	catalytic residue [active]
526226005073	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226005074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226005075	Coenzyme A binding pocket [chemical binding]; other site
526226005076	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
526226005077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226005078	S-adenosylmethionine binding site [chemical binding]; other site
526226005079	Nitronate monooxygenase; Region: NMO; pfam03060
526226005080	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
526226005081	FMN binding site [chemical binding]; other site
526226005082	substrate binding site [chemical binding]; other site
526226005083	putative catalytic residue [active]
526226005084	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
526226005085	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
526226005086	active site
526226005087	(T/H)XGH motif; other site
526226005088	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
526226005089	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
526226005090	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
526226005091	ribonuclease III; Reviewed; Region: rnc; PRK00102
526226005092	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
526226005093	dimerization interface [polypeptide binding]; other site
526226005094	active site
526226005095	metal binding site [ion binding]; metal-binding site
526226005096	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
526226005097	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
526226005098	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
526226005099	DNA binding site [nucleotide binding]
526226005100	catalytic residue [active]
526226005101	H2TH interface [polypeptide binding]; other site
526226005102	putative catalytic residues [active]
526226005103	turnover-facilitating residue; other site
526226005104	intercalation triad [nucleotide binding]; other site
526226005105	8OG recognition residue [nucleotide binding]; other site
526226005106	putative reading head residues; other site
526226005107	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
526226005108	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
526226005109	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
526226005110	acylphosphatase; Provisional; Region: PRK14422
526226005111	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
526226005112	AAA domain; Region: AAA_23; pfam13476
526226005113	Walker A/P-loop; other site
526226005114	ATP binding site [chemical binding]; other site
526226005115	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
526226005116	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
526226005117	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
526226005118	ABC transporter signature motif; other site
526226005119	Walker B; other site
526226005120	D-loop; other site
526226005121	H-loop/switch region; other site
526226005122	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
526226005123	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
526226005124	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526226005125	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
526226005126	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
526226005127	Nitrogen regulatory protein P-II; Region: P-II; smart00938
526226005128	PII uridylyl-transferase; Provisional; Region: PRK03381
526226005129	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
526226005130	metal binding triad; other site
526226005131	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
526226005132	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
526226005133	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
526226005134	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
526226005135	signal recognition particle protein; Provisional; Region: PRK10867
526226005136	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
526226005137	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
526226005138	P loop; other site
526226005139	GTP binding site [chemical binding]; other site
526226005140	Signal peptide binding domain; Region: SRP_SPB; pfam02978
526226005141	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526226005142	Amidohydrolase; Region: Amidohydro_4; pfam13147
526226005143	active site
526226005144	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
526226005145	hypothetical protein; Provisional; Region: PRK02821
526226005146	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
526226005147	G-X-X-G motif; other site
526226005148	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
526226005149	RimM N-terminal domain; Region: RimM; pfam01782
526226005150	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
526226005151	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
526226005152	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
526226005153	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
526226005154	Catalytic site [active]
526226005155	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
526226005156	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
526226005157	RNA/DNA hybrid binding site [nucleotide binding]; other site
526226005158	active site
526226005159	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
526226005160	Amino acid permease; Region: AA_permease_2; pfam13520
526226005161	hypothetical protein; Reviewed; Region: PRK12497
526226005162	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
526226005163	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
526226005164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226005165	Walker A motif; other site
526226005166	ATP binding site [chemical binding]; other site
526226005167	Walker B motif; other site
526226005168	arginine finger; other site
526226005169	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
526226005170	DNA protecting protein DprA; Region: dprA; TIGR00732
526226005171	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
526226005172	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226005173	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226005174	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
526226005175	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
526226005176	FAD binding pocket [chemical binding]; other site
526226005177	FAD binding motif [chemical binding]; other site
526226005178	phosphate binding motif [ion binding]; other site
526226005179	NAD binding pocket [chemical binding]; other site
526226005180	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
526226005181	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226005182	active site
526226005183	DNA binding site [nucleotide binding]
526226005184	Int/Topo IB signature motif; other site
526226005185	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226005186	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
526226005187	rRNA interaction site [nucleotide binding]; other site
526226005188	S8 interaction site; other site
526226005189	putative laminin-1 binding site; other site
526226005190	elongation factor Ts; Provisional; Region: tsf; PRK09377
526226005191	UBA/TS-N domain; Region: UBA; pfam00627
526226005192	Elongation factor TS; Region: EF_TS; pfam00889
526226005193	Elongation factor TS; Region: EF_TS; pfam00889
526226005194	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
526226005195	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526226005196	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
526226005197	putative nucleotide binding site [chemical binding]; other site
526226005198	uridine monophosphate binding site [chemical binding]; other site
526226005199	homohexameric interface [polypeptide binding]; other site
526226005200	ribosome recycling factor; Reviewed; Region: frr; PRK00083
526226005201	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
526226005202	hinge region; other site
526226005203	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
526226005204	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
526226005205	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
526226005206	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226005207	FeS/SAM binding site; other site
526226005208	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
526226005209	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
526226005210	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
526226005211	active site
526226005212	catalytic site [active]
526226005213	tetramer interface [polypeptide binding]; other site
526226005214	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
526226005215	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
526226005216	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
526226005217	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
526226005218	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
526226005219	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
526226005220	active site
526226005221	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
526226005222	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
526226005223	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
526226005224	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
526226005225	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
526226005226	Predicted acetyltransferase [General function prediction only]; Region: COG3393
526226005227	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
526226005228	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526226005229	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
526226005230	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
526226005231	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526226005232	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
526226005233	Walker A/P-loop; other site
526226005234	ATP binding site [chemical binding]; other site
526226005235	Q-loop/lid; other site
526226005236	ABC transporter signature motif; other site
526226005237	Walker B; other site
526226005238	D-loop; other site
526226005239	H-loop/switch region; other site
526226005240	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
526226005241	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526226005242	dimer interface [polypeptide binding]; other site
526226005243	putative PBP binding regions; other site
526226005244	ABC-ATPase subunit  interface; other site
526226005245	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
526226005246	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526226005247	intersubunit interface [polypeptide binding]; other site
526226005248	methionine aminopeptidase; Provisional; Region: PRK12318
526226005249	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
526226005250	active site
526226005251	TIGR02147 family protein; Region: Fsuc_second
526226005252	cobyric acid synthase; Provisional; Region: PRK00784
526226005253	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526226005254	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
526226005255	catalytic triad [active]
526226005256	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226005257	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226005258	mycothione reductase; Reviewed; Region: PRK07846
526226005259	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226005260	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526226005261	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226005262	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
526226005263	malate:quinone oxidoreductase; Validated; Region: PRK05257
526226005264	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
526226005265	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226005266	Coenzyme A binding pocket [chemical binding]; other site
526226005267	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
526226005268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226005269	Walker A motif; other site
526226005270	ATP binding site [chemical binding]; other site
526226005271	Walker B motif; other site
526226005272	arginine finger; other site
526226005273	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526226005274	metal ion-dependent adhesion site (MIDAS); other site
526226005275	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
526226005276	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
526226005277	homodimer interface [polypeptide binding]; other site
526226005278	Walker A motif; other site
526226005279	ATP binding site [chemical binding]; other site
526226005280	hydroxycobalamin binding site [chemical binding]; other site
526226005281	Walker B motif; other site
526226005282	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
526226005283	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526226005284	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
526226005285	catalytic triad [active]
526226005286	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
526226005287	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
526226005288	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526226005289	Histidine kinase; Region: HisKA_3; pfam07730
526226005290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226005291	Mg2+ binding site [ion binding]; other site
526226005292	G-X-G motif; other site
526226005293	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226005294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226005295	active site
526226005296	phosphorylation site [posttranslational modification]
526226005297	intermolecular recognition site; other site
526226005298	dimerization interface [polypeptide binding]; other site
526226005299	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226005300	DNA binding residues [nucleotide binding]
526226005301	dimerization interface [polypeptide binding]; other site
526226005302	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
526226005303	homodimer interface [polypeptide binding]; other site
526226005304	putative substrate binding pocket [chemical binding]; other site
526226005305	diiron center [ion binding]; other site
526226005306	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
526226005307	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
526226005308	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
526226005309	active site
526226005310	SAM binding site [chemical binding]; other site
526226005311	homodimer interface [polypeptide binding]; other site
526226005312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226005313	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226005314	putative substrate translocation pore; other site
526226005315	AAA domain; Region: AAA_33; pfam13671
526226005316	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
526226005317	active site
526226005318	hypothetical protein; Validated; Region: PRK02101
526226005319	prolyl-tRNA synthetase; Provisional; Region: PRK09194
526226005320	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
526226005321	dimer interface [polypeptide binding]; other site
526226005322	motif 1; other site
526226005323	active site
526226005324	motif 2; other site
526226005325	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
526226005326	putative deacylase active site [active]
526226005327	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526226005328	active site
526226005329	motif 3; other site
526226005330	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
526226005331	anticodon binding site; other site
526226005332	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
526226005333	dinuclear metal binding motif [ion binding]; other site
526226005334	ribosome maturation protein RimP; Reviewed; Region: PRK00092
526226005335	Sm and related proteins; Region: Sm_like; cl00259
526226005336	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
526226005337	putative oligomer interface [polypeptide binding]; other site
526226005338	putative RNA binding site [nucleotide binding]; other site
526226005339	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
526226005340	NusA N-terminal domain; Region: NusA_N; pfam08529
526226005341	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
526226005342	RNA binding site [nucleotide binding]; other site
526226005343	homodimer interface [polypeptide binding]; other site
526226005344	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
526226005345	G-X-X-G motif; other site
526226005346	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
526226005347	G-X-X-G motif; other site
526226005348	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
526226005349	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
526226005350	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
526226005351	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
526226005352	G1 box; other site
526226005353	putative GEF interaction site [polypeptide binding]; other site
526226005354	GTP/Mg2+ binding site [chemical binding]; other site
526226005355	Switch I region; other site
526226005356	G2 box; other site
526226005357	G3 box; other site
526226005358	Switch II region; other site
526226005359	G4 box; other site
526226005360	G5 box; other site
526226005361	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
526226005362	Translation-initiation factor 2; Region: IF-2; pfam11987
526226005363	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
526226005364	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
526226005365	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
526226005366	DHH family; Region: DHH; pfam01368
526226005367	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
526226005368	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
526226005369	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526226005370	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526226005371	active site
526226005372	metal binding site [ion binding]; metal-binding site
526226005373	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
526226005374	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
526226005375	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
526226005376	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
526226005377	RNA binding site [nucleotide binding]; other site
526226005378	active site
526226005379	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
526226005380	yiaA/B two helix domain; Region: YiaAB; cl01759
526226005381	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
526226005382	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226005383	putative DNA binding site [nucleotide binding]; other site
526226005384	dimerization interface [polypeptide binding]; other site
526226005385	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
526226005386	FeoA domain; Region: FeoA; pfam04023
526226005387	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
526226005388	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
526226005389	active site
526226005390	Riboflavin kinase; Region: Flavokinase; smart00904
526226005391	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
526226005392	16S/18S rRNA binding site [nucleotide binding]; other site
526226005393	S13e-L30e interaction site [polypeptide binding]; other site
526226005394	25S rRNA binding site [nucleotide binding]; other site
526226005395	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
526226005396	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
526226005397	oligomer interface [polypeptide binding]; other site
526226005398	RNA binding site [nucleotide binding]; other site
526226005399	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
526226005400	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
526226005401	RNase E interface [polypeptide binding]; other site
526226005402	trimer interface [polypeptide binding]; other site
526226005403	active site
526226005404	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
526226005405	putative nucleic acid binding region [nucleotide binding]; other site
526226005406	G-X-X-G motif; other site
526226005407	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
526226005408	RNA binding site [nucleotide binding]; other site
526226005409	domain interface; other site
526226005410	FOG: CBS domain [General function prediction only]; Region: COG0517
526226005411	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
526226005412	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
526226005413	metal binding triad; other site
526226005414	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
526226005415	NRDE protein; Region: NRDE; cl01315
526226005416	Transposase; Region: HTH_Tnp_1; cl17663
526226005417	putative transposase OrfB; Reviewed; Region: PHA02517
526226005418	HTH-like domain; Region: HTH_21; pfam13276
526226005419	Integrase core domain; Region: rve; pfam00665
526226005420	Integrase core domain; Region: rve_3; pfam13683
526226005421	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
526226005422	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
526226005423	hexamer interface [polypeptide binding]; other site
526226005424	ligand binding site [chemical binding]; other site
526226005425	putative active site [active]
526226005426	NAD(P) binding site [chemical binding]; other site
526226005427	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
526226005428	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
526226005429	putative DNA binding site [nucleotide binding]; other site
526226005430	putative Zn2+ binding site [ion binding]; other site
526226005431	AsnC family; Region: AsnC_trans_reg; pfam01037
526226005432	dihydrodipicolinate reductase; Provisional; Region: PRK00048
526226005433	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
526226005434	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
526226005435	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
526226005436	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526226005437	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226005438	active site
526226005439	thymidylate synthase; Reviewed; Region: thyA; PRK01827
526226005440	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
526226005441	dimerization interface [polypeptide binding]; other site
526226005442	active site
526226005443	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526226005444	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
526226005445	folate binding site [chemical binding]; other site
526226005446	NADP+ binding site [chemical binding]; other site
526226005447	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
526226005448	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
526226005449	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
526226005450	Prostaglandin dehydrogenases; Region: PGDH; cd05288
526226005451	NAD(P) binding site [chemical binding]; other site
526226005452	substrate binding site [chemical binding]; other site
526226005453	dimer interface [polypeptide binding]; other site
526226005454	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
526226005455	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226005456	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226005457	Eukaryotic phosphomannomutase; Region: PMM; cl17107
526226005458	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
526226005459	Eukaryotic phosphomannomutase; Region: PMM; cl17107
526226005460	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
526226005461	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
526226005462	PhoD-like phosphatase; Region: PhoD; pfam09423
526226005463	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
526226005464	putative active site [active]
526226005465	putative metal binding site [ion binding]; other site
526226005466	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526226005467	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
526226005468	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
526226005469	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226005470	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526226005471	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226005472	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
526226005473	putative dimerization interface [polypeptide binding]; other site
526226005474	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526226005475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226005476	S-adenosylmethionine binding site [chemical binding]; other site
526226005477	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
526226005478	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
526226005479	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
526226005480	dimer interface [polypeptide binding]; other site
526226005481	active site
526226005482	catalytic residue [active]
526226005483	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
526226005484	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526226005485	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
526226005486	TIGR03085 family protein; Region: TIGR03085
526226005487	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526226005488	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
526226005489	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
526226005490	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
526226005491	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
526226005492	YCII-related domain; Region: YCII; cl00999
526226005493	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226005494	Coenzyme A binding pocket [chemical binding]; other site
526226005495	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
526226005496	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226005497	non-specific DNA binding site [nucleotide binding]; other site
526226005498	salt bridge; other site
526226005499	sequence-specific DNA binding site [nucleotide binding]; other site
526226005500	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
526226005501	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
526226005502	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
526226005503	recombinase A; Provisional; Region: recA; PRK09354
526226005504	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
526226005505	hexamer interface [polypeptide binding]; other site
526226005506	Walker A motif; other site
526226005507	ATP binding site [chemical binding]; other site
526226005508	Walker B motif; other site
526226005509	recombination regulator RecX; Reviewed; Region: recX; PRK00117
526226005510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226005511	dimer interface [polypeptide binding]; other site
526226005512	conserved gate region; other site
526226005513	putative PBP binding loops; other site
526226005514	ABC-ATPase subunit interface; other site
526226005515	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
526226005516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226005517	dimer interface [polypeptide binding]; other site
526226005518	conserved gate region; other site
526226005519	putative PBP binding loops; other site
526226005520	ABC-ATPase subunit interface; other site
526226005521	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
526226005522	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526226005523	substrate binding pocket [chemical binding]; other site
526226005524	membrane-bound complex binding site; other site
526226005525	hinge residues; other site
526226005526	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526226005527	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
526226005528	Walker A/P-loop; other site
526226005529	ATP binding site [chemical binding]; other site
526226005530	Q-loop/lid; other site
526226005531	ABC transporter signature motif; other site
526226005532	Walker B; other site
526226005533	D-loop; other site
526226005534	H-loop/switch region; other site
526226005535	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
526226005536	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
526226005537	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226005538	FeS/SAM binding site; other site
526226005539	Homeodomain-like domain; Region: HTH_23; pfam13384
526226005540	Winged helix-turn helix; Region: HTH_29; pfam13551
526226005541	Homeodomain-like domain; Region: HTH_32; pfam13565
526226005542	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226005543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226005544	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
526226005545	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
526226005546	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
526226005547	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
526226005548	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
526226005549	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
526226005550	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
526226005551	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
526226005552	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
526226005553	GTPases [General function prediction only]; Region: HflX; COG2262
526226005554	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
526226005555	HflX GTPase family; Region: HflX; cd01878
526226005556	G1 box; other site
526226005557	GTP/Mg2+ binding site [chemical binding]; other site
526226005558	Switch I region; other site
526226005559	G2 box; other site
526226005560	G3 box; other site
526226005561	Switch II region; other site
526226005562	G4 box; other site
526226005563	G5 box; other site
526226005564	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
526226005565	dimerization domain swap beta strand [polypeptide binding]; other site
526226005566	regulatory protein interface [polypeptide binding]; other site
526226005567	active site
526226005568	regulatory phosphorylation site [posttranslational modification]; other site
526226005569	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
526226005570	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
526226005571	active site
526226005572	phosphorylation site [posttranslational modification]
526226005573	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
526226005574	active site
526226005575	P-loop; other site
526226005576	phosphorylation site [posttranslational modification]
526226005577	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
526226005578	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
526226005579	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
526226005580	putative substrate binding site [chemical binding]; other site
526226005581	putative ATP binding site [chemical binding]; other site
526226005582	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
526226005583	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
526226005584	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
526226005585	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
526226005586	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
526226005587	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
526226005588	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
526226005589	LexA repressor; Validated; Region: PRK00215
526226005590	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
526226005591	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
526226005592	Catalytic site [active]
526226005593	LysM domain; Region: LysM; pfam01476
526226005594	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
526226005595	ATP cone domain; Region: ATP-cone; pfam03477
526226005596	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
526226005597	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226005598	ATP binding site [chemical binding]; other site
526226005599	putative Mg++ binding site [ion binding]; other site
526226005600	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226005601	nucleotide binding region [chemical binding]; other site
526226005602	ATP-binding site [chemical binding]; other site
526226005603	Helicase associated domain (HA2); Region: HA2; pfam04408
526226005604	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
526226005605	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
526226005606	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
526226005607	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526226005608	inhibitor-cofactor binding pocket; inhibition site
526226005609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226005610	catalytic residue [active]
526226005611	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
526226005612	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
526226005613	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
526226005614	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
526226005615	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
526226005616	dimer interface [polypeptide binding]; other site
526226005617	decamer (pentamer of dimers) interface [polypeptide binding]; other site
526226005618	catalytic triad [active]
526226005619	peroxidatic and resolving cysteines [active]
526226005620	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
526226005621	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226005622	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
526226005623	dimerization interface [polypeptide binding]; other site
526226005624	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226005625	ATP binding site [chemical binding]; other site
526226005626	putative Mg++ binding site [ion binding]; other site
526226005627	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226005628	nucleotide binding region [chemical binding]; other site
526226005629	ATP-binding site [chemical binding]; other site
526226005630	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
526226005631	PAC2 family; Region: PAC2; pfam09754
526226005632	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
526226005633	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
526226005634	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
526226005635	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
526226005636	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
526226005637	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
526226005638	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
526226005639	active site
526226005640	Zn binding site [ion binding]; other site
526226005641	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226005642	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226005643	Coenzyme A binding pocket [chemical binding]; other site
526226005644	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
526226005645	CoA binding domain; Region: CoA_binding_2; pfam13380
526226005646	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
526226005647	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
526226005648	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
526226005649	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
526226005650	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226005651	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526226005652	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226005653	DNA binding residues [nucleotide binding]
526226005654	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
526226005655	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
526226005656	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
526226005657	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
526226005658	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226005659	ATP binding site [chemical binding]; other site
526226005660	putative Mg++ binding site [ion binding]; other site
526226005661	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526226005662	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
526226005663	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226005664	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526226005665	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226005666	DNA binding residues [nucleotide binding]
526226005667	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
526226005668	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526226005669	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
526226005670	dimerization interface [polypeptide binding]; other site
526226005671	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
526226005672	active site
526226005673	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526226005674	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
526226005675	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
526226005676	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
526226005677	trimer interface [polypeptide binding]; other site
526226005678	active site
526226005679	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
526226005680	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526226005681	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
526226005682	ssDNA binding site; other site
526226005683	generic binding surface II; other site
526226005684	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
526226005685	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
526226005686	TrkA-N domain; Region: TrkA_N; pfam02254
526226005687	TrkA-C domain; Region: TrkA_C; pfam02080
526226005688	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
526226005689	TrkA-N domain; Region: TrkA_N; pfam02254
526226005690	TrkA-C domain; Region: TrkA_C; pfam02080
526226005691	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
526226005692	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
526226005693	TRAM domain; Region: TRAM; pfam01938
526226005694	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
526226005695	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
526226005696	TPP-binding site; other site
526226005697	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526226005698	PYR/PP interface [polypeptide binding]; other site
526226005699	dimer interface [polypeptide binding]; other site
526226005700	TPP binding site [chemical binding]; other site
526226005701	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526226005702	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
526226005703	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
526226005704	catalytic site [active]
526226005705	putative active site [active]
526226005706	putative substrate binding site [chemical binding]; other site
526226005707	Helicase and RNase D C-terminal; Region: HRDC; smart00341
526226005708	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
526226005709	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
526226005710	substrate binding site [chemical binding]; other site
526226005711	active site
526226005712	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
526226005713	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226005714	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
526226005715	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
526226005716	active site
526226005717	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
526226005718	SelR domain; Region: SelR; pfam01641
526226005719	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
526226005720	DivIVA protein; Region: DivIVA; pfam05103
526226005721	DivIVA domain; Region: DivI1A_domain; TIGR03544
526226005722	TAP-like protein; Region: Abhydrolase_4; pfam08386
526226005723	hypothetical protein; Provisional; Region: PRK14059
526226005724	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
526226005725	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
526226005726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226005727	Walker A motif; other site
526226005728	ATP binding site [chemical binding]; other site
526226005729	Walker B motif; other site
526226005730	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226005731	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226005732	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
526226005733	active site
526226005734	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526226005735	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226005736	Coenzyme A binding pocket [chemical binding]; other site
526226005737	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
526226005738	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
526226005739	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226005740	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
526226005741	dimerization interface [polypeptide binding]; other site
526226005742	substrate binding pocket [chemical binding]; other site
526226005743	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
526226005744	hydrophobic ligand binding site; other site
526226005745	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226005746	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
526226005747	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
526226005748	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
526226005749	catalytic residues [active]
526226005750	catalytic nucleophile [active]
526226005751	Presynaptic Site I dimer interface [polypeptide binding]; other site
526226005752	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
526226005753	Synaptic Flat tetramer interface [polypeptide binding]; other site
526226005754	Synaptic Site I dimer interface [polypeptide binding]; other site
526226005755	DNA binding site [nucleotide binding]
526226005756	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
526226005757	DNA-binding interface [nucleotide binding]; DNA binding site
526226005758	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
526226005759	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
526226005760	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
526226005761	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
526226005762	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
526226005763	active site
526226005764	dimer interface [polypeptide binding]; other site
526226005765	motif 1; other site
526226005766	motif 2; other site
526226005767	motif 3; other site
526226005768	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
526226005769	anticodon binding site; other site
526226005770	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
526226005771	nucleotide binding site/active site [active]
526226005772	HIT family signature motif; other site
526226005773	catalytic residue [active]
526226005774	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
526226005775	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
526226005776	putative acyl-acceptor binding pocket; other site
526226005777	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226005778	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226005779	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
526226005780	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
526226005781	active site
526226005782	multimer interface [polypeptide binding]; other site
526226005783	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
526226005784	Protein phosphatase 2C; Region: PP2C; pfam00481
526226005785	active site
526226005786	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226005787	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226005788	DNA binding residues [nucleotide binding]
526226005789	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
526226005790	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
526226005791	active site
526226005792	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
526226005793	catalytic triad [active]
526226005794	dimer interface [polypeptide binding]; other site
526226005795	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
526226005796	predicted active site [active]
526226005797	catalytic triad [active]
526226005798	hypothetical protein; Validated; Region: PRK00110
526226005799	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
526226005800	active site
526226005801	putative DNA-binding cleft [nucleotide binding]; other site
526226005802	dimer interface [polypeptide binding]; other site
526226005803	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
526226005804	RuvA N terminal domain; Region: RuvA_N; pfam01330
526226005805	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
526226005806	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
526226005807	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226005808	Walker A motif; other site
526226005809	ATP binding site [chemical binding]; other site
526226005810	Walker B motif; other site
526226005811	arginine finger; other site
526226005812	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
526226005813	Preprotein translocase subunit; Region: YajC; pfam02699
526226005814	protein-export membrane protein SecD; Region: secD; TIGR01129
526226005815	Protein export membrane protein; Region: SecD_SecF; cl14618
526226005816	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
526226005817	Protein export membrane protein; Region: SecD_SecF; cl14618
526226005818	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
526226005819	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
526226005820	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226005821	active site
526226005822	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
526226005823	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526226005824	Zn2+ binding site [ion binding]; other site
526226005825	Mg2+ binding site [ion binding]; other site
526226005826	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
526226005827	synthetase active site [active]
526226005828	NTP binding site [chemical binding]; other site
526226005829	metal binding site [ion binding]; metal-binding site
526226005830	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
526226005831	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
526226005832	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
526226005833	active site
526226005834	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
526226005835	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
526226005836	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
526226005837	dimer interface [polypeptide binding]; other site
526226005838	motif 1; other site
526226005839	active site
526226005840	motif 2; other site
526226005841	motif 3; other site
526226005842	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
526226005843	anticodon binding site; other site
526226005844	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
526226005845	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
526226005846	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
526226005847	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
526226005848	dimer interface [polypeptide binding]; other site
526226005849	anticodon binding site; other site
526226005850	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
526226005851	homodimer interface [polypeptide binding]; other site
526226005852	motif 1; other site
526226005853	active site
526226005854	motif 2; other site
526226005855	GAD domain; Region: GAD; pfam02938
526226005856	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526226005857	active site
526226005858	motif 3; other site
526226005859	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
526226005860	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
526226005861	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
526226005862	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
526226005863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
526226005864	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
526226005865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
526226005866	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
526226005867	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
526226005868	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
526226005869	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
526226005870	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
526226005871	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
526226005872	recombination factor protein RarA; Reviewed; Region: PRK13342
526226005873	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226005874	Walker A motif; other site
526226005875	ATP binding site [chemical binding]; other site
526226005876	Walker B motif; other site
526226005877	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
526226005878	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
526226005879	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
526226005880	motif 1; other site
526226005881	active site
526226005882	motif 2; other site
526226005883	motif 3; other site
526226005884	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
526226005885	DHHA1 domain; Region: DHHA1; pfam02272
526226005886	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
526226005887	YceG-like family; Region: YceG; pfam02618
526226005888	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
526226005889	dimerization interface [polypeptide binding]; other site
526226005890	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
526226005891	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
526226005892	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
526226005893	shikimate binding site; other site
526226005894	NAD(P) binding site [chemical binding]; other site
526226005895	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
526226005896	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
526226005897	Tetramer interface [polypeptide binding]; other site
526226005898	active site
526226005899	FMN-binding site [chemical binding]; other site
526226005900	shikimate kinase; Reviewed; Region: aroK; PRK00131
526226005901	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
526226005902	ADP binding site [chemical binding]; other site
526226005903	magnesium binding site [ion binding]; other site
526226005904	putative shikimate binding site; other site
526226005905	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
526226005906	dimer interface [polypeptide binding]; other site
526226005907	active site
526226005908	metal binding site [ion binding]; metal-binding site
526226005909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226005910	metabolite-proton symporter; Region: 2A0106; TIGR00883
526226005911	putative substrate translocation pore; other site
526226005912	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
526226005913	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
526226005914	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
526226005915	active site
526226005916	elongation factor P; Validated; Region: PRK00529
526226005917	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
526226005918	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
526226005919	RNA binding site [nucleotide binding]; other site
526226005920	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
526226005921	RNA binding site [nucleotide binding]; other site
526226005922	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
526226005923	putative RNA binding site [nucleotide binding]; other site
526226005924	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
526226005925	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226005926	active site
526226005927	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
526226005928	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
526226005929	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
526226005930	dihydroorotase; Validated; Region: pyrC; PRK09357
526226005931	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526226005932	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
526226005933	active site
526226005934	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
526226005935	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
526226005936	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
526226005937	catalytic site [active]
526226005938	subunit interface [polypeptide binding]; other site
526226005939	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
526226005940	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526226005941	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526226005942	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
526226005943	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526226005944	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526226005945	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
526226005946	IMP binding site; other site
526226005947	dimer interface [polypeptide binding]; other site
526226005948	interdomain contacts; other site
526226005949	partial ornithine binding site; other site
526226005950	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
526226005951	active site
526226005952	dimer interface [polypeptide binding]; other site
526226005953	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226005954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226005955	active site
526226005956	phosphorylation site [posttranslational modification]
526226005957	intermolecular recognition site; other site
526226005958	dimerization interface [polypeptide binding]; other site
526226005959	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226005960	DNA binding residues [nucleotide binding]
526226005961	dimerization interface [polypeptide binding]; other site
526226005962	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
526226005963	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
526226005964	catalytic site [active]
526226005965	G-X2-G-X-G-K; other site
526226005966	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
526226005967	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
526226005968	Flavoprotein; Region: Flavoprotein; pfam02441
526226005969	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
526226005970	S-adenosylmethionine synthetase; Validated; Region: PRK05250
526226005971	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
526226005972	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
526226005973	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
526226005974	primosome assembly protein PriA; Provisional; Region: PRK14873
526226005975	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
526226005976	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
526226005977	putative active site [active]
526226005978	substrate binding site [chemical binding]; other site
526226005979	putative cosubstrate binding site; other site
526226005980	catalytic site [active]
526226005981	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
526226005982	substrate binding site [chemical binding]; other site
526226005983	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
526226005984	16S rRNA methyltransferase B; Provisional; Region: PRK14902
526226005985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226005986	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
526226005987	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
526226005988	substrate binding site [chemical binding]; other site
526226005989	hexamer interface [polypeptide binding]; other site
526226005990	metal binding site [ion binding]; metal-binding site
526226005991	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
526226005992	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
526226005993	catalytic motif [active]
526226005994	Zn binding site [ion binding]; other site
526226005995	RibD C-terminal domain; Region: RibD_C; cl17279
526226005996	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
526226005997	Lumazine binding domain; Region: Lum_binding; pfam00677
526226005998	Lumazine binding domain; Region: Lum_binding; pfam00677
526226005999	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
526226006000	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
526226006001	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
526226006002	dimerization interface [polypeptide binding]; other site
526226006003	active site
526226006004	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
526226006005	homopentamer interface [polypeptide binding]; other site
526226006006	active site
526226006007	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
526226006008	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
526226006009	Leucine carboxyl methyltransferase; Region: LCM; cl01306
526226006010	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
526226006011	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
526226006012	GIY-YIG motif/motif A; other site
526226006013	active site
526226006014	catalytic site [active]
526226006015	putative DNA binding site [nucleotide binding]; other site
526226006016	metal binding site [ion binding]; metal-binding site
526226006017	UvrB/uvrC motif; Region: UVR; pfam02151
526226006018	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
526226006019	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
526226006020	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
526226006021	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
526226006022	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
526226006023	phosphate binding site [ion binding]; other site
526226006024	putative substrate binding pocket [chemical binding]; other site
526226006025	dimer interface [polypeptide binding]; other site
526226006026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
526226006027	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
526226006028	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
526226006029	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
526226006030	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
526226006031	Phosphoglycerate kinase; Region: PGK; pfam00162
526226006032	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
526226006033	substrate binding site [chemical binding]; other site
526226006034	hinge regions; other site
526226006035	ADP binding site [chemical binding]; other site
526226006036	catalytic site [active]
526226006037	triosephosphate isomerase; Provisional; Region: PRK14567
526226006038	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
526226006039	substrate binding site [chemical binding]; other site
526226006040	dimer interface [polypeptide binding]; other site
526226006041	catalytic triad [active]
526226006042	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
526226006043	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
526226006044	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
526226006045	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
526226006046	hypothetical protein; Validated; Region: PRK07581
526226006047	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
526226006048	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
526226006049	putative active site [active]
526226006050	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
526226006051	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
526226006052	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
526226006053	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
526226006054	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
526226006055	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
526226006056	putative active site [active]
526226006057	transaldolase; Provisional; Region: PRK03903
526226006058	catalytic residue [active]
526226006059	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
526226006060	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
526226006061	TPP-binding site [chemical binding]; other site
526226006062	dimer interface [polypeptide binding]; other site
526226006063	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
526226006064	PYR/PP interface [polypeptide binding]; other site
526226006065	dimer interface [polypeptide binding]; other site
526226006066	TPP binding site [chemical binding]; other site
526226006067	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
526226006068	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
526226006069	UbiA prenyltransferase family; Region: UbiA; pfam01040
526226006070	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
526226006071	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
526226006072	NADP binding site [chemical binding]; other site
526226006073	dimer interface [polypeptide binding]; other site
526226006074	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
526226006075	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
526226006076	ABC-2 type transporter; Region: ABC2_membrane; cl17235
526226006077	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526226006078	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526226006079	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526226006080	Walker A/P-loop; other site
526226006081	ATP binding site [chemical binding]; other site
526226006082	Q-loop/lid; other site
526226006083	ABC transporter signature motif; other site
526226006084	Walker B; other site
526226006085	D-loop; other site
526226006086	H-loop/switch region; other site
526226006087	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
526226006088	Predicted transcriptional regulator [Transcription]; Region: COG2345
526226006089	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006090	putative DNA binding site [nucleotide binding]; other site
526226006091	putative Zn2+ binding site [ion binding]; other site
526226006092	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
526226006093	FeS assembly protein SufB; Region: sufB; TIGR01980
526226006094	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
526226006095	FeS assembly protein SufD; Region: sufD; TIGR01981
526226006096	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
526226006097	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
526226006098	Walker A/P-loop; other site
526226006099	ATP binding site [chemical binding]; other site
526226006100	Q-loop/lid; other site
526226006101	ABC transporter signature motif; other site
526226006102	Walker B; other site
526226006103	D-loop; other site
526226006104	H-loop/switch region; other site
526226006105	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
526226006106	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
526226006107	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226006108	catalytic residue [active]
526226006109	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
526226006110	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
526226006111	trimerization site [polypeptide binding]; other site
526226006112	active site
526226006113	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
526226006114	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
526226006115	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
526226006116	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226006117	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
526226006118	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
526226006119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
526226006120	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
526226006121	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526226006122	active site
526226006123	metal binding site [ion binding]; metal-binding site
526226006124	Homeodomain-like domain; Region: HTH_23; pfam13384
526226006125	Winged helix-turn helix; Region: HTH_29; pfam13551
526226006126	Homeodomain-like domain; Region: HTH_32; pfam13565
526226006127	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226006128	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226006129	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
526226006130	lycopene cyclase; Region: lycopene_cycl; TIGR01789
526226006131	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
526226006132	classical (c) SDRs; Region: SDR_c; cd05233
526226006133	NAD(P) binding site [chemical binding]; other site
526226006134	active site
526226006135	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526226006136	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226006137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226006138	Walker A/P-loop; other site
526226006139	ATP binding site [chemical binding]; other site
526226006140	Q-loop/lid; other site
526226006141	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226006142	ABC transporter signature motif; other site
526226006143	Walker B; other site
526226006144	D-loop; other site
526226006145	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226006146	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226006147	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
526226006148	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
526226006149	acyl-activating enzyme (AAE) consensus motif; other site
526226006150	putative AMP binding site [chemical binding]; other site
526226006151	putative active site [active]
526226006152	putative CoA binding site [chemical binding]; other site
526226006153	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
526226006154	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526226006155	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
526226006156	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226006157	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526226006158	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226006159	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226006160	aconitate hydratase; Validated; Region: PRK09277
526226006161	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
526226006162	substrate binding site [chemical binding]; other site
526226006163	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
526226006164	ligand binding site [chemical binding]; other site
526226006165	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
526226006166	substrate binding site [chemical binding]; other site
526226006167	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
526226006168	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526226006169	NlpC/P60 family; Region: NLPC_P60; pfam00877
526226006170	MoxR-like ATPases [General function prediction only]; Region: COG0714
526226006171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226006172	Walker A motif; other site
526226006173	ATP binding site [chemical binding]; other site
526226006174	Walker B motif; other site
526226006175	arginine finger; other site
526226006176	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
526226006177	Protein of unknown function DUF58; Region: DUF58; pfam01882
526226006178	hypothetical protein; Provisional; Region: PRK13685
526226006179	von Willebrand factor type A domain; Region: VWA_2; pfam13519
526226006180	metal ion-dependent adhesion site (MIDAS); other site
526226006181	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
526226006182	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
526226006183	NAD(P) binding site [chemical binding]; other site
526226006184	homotetramer interface [polypeptide binding]; other site
526226006185	homodimer interface [polypeptide binding]; other site
526226006186	active site
526226006187	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
526226006188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226006189	NAD(P) binding site [chemical binding]; other site
526226006190	active site
526226006191	ferrochelatase; Reviewed; Region: hemH; PRK00035
526226006192	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
526226006193	C-terminal domain interface [polypeptide binding]; other site
526226006194	active site
526226006195	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
526226006196	active site
526226006197	N-terminal domain interface [polypeptide binding]; other site
526226006198	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
526226006199	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
526226006200	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
526226006201	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
526226006202	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
526226006203	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
526226006204	putative Zn2+ binding site [ion binding]; other site
526226006205	Uncharacterized conserved protein [Function unknown]; Region: COG0398
526226006206	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
526226006207	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
526226006208	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
526226006209	heterodimer interface [polypeptide binding]; other site
526226006210	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
526226006211	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
526226006212	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
526226006213	active site
526226006214	substrate binding site [chemical binding]; other site
526226006215	coenzyme B12 binding site [chemical binding]; other site
526226006216	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
526226006217	B12 binding site [chemical binding]; other site
526226006218	cobalt ligand [ion binding]; other site
526226006219	membrane ATPase/protein kinase; Provisional; Region: PRK09435
526226006220	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
526226006221	Walker A; other site
526226006222	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
526226006223	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526226006224	intersubunit interface [polypeptide binding]; other site
526226006225	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226006226	NAD(P) binding site [chemical binding]; other site
526226006227	active site
526226006228	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
526226006229	Isochorismatase family; Region: Isochorismatase; pfam00857
526226006230	catalytic triad [active]
526226006231	conserved cis-peptide bond; other site
526226006232	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
526226006233	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
526226006234	acyl-activating enzyme (AAE) consensus motif; other site
526226006235	active site
526226006236	AMP binding site [chemical binding]; other site
526226006237	substrate binding site [chemical binding]; other site
526226006238	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
526226006239	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226006240	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226006241	acyl-activating enzyme (AAE) consensus motif; other site
526226006242	AMP binding site [chemical binding]; other site
526226006243	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226006244	Condensation domain; Region: Condensation; pfam00668
526226006245	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226006246	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226006247	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226006248	acyl-activating enzyme (AAE) consensus motif; other site
526226006249	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226006250	AMP binding site [chemical binding]; other site
526226006251	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226006252	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226006253	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
526226006254	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
526226006255	active site
526226006256	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
526226006257	Mechanosensitive ion channel; Region: MS_channel; pfam00924
526226006258	hypothetical protein; Provisional; Region: PRK07906
526226006259	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
526226006260	putative metal binding site [ion binding]; other site
526226006261	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
526226006262	substrate binding site [chemical binding]; other site
526226006263	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
526226006264	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
526226006265	quinone interaction residues [chemical binding]; other site
526226006266	active site
526226006267	catalytic residues [active]
526226006268	FMN binding site [chemical binding]; other site
526226006269	substrate binding site [chemical binding]; other site
526226006270	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
526226006271	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226006272	catalytic core [active]
526226006273	conserved hypothetical protein; Region: TIGR03847
526226006274	conserved hypothetical protein; Region: TIGR03843
526226006275	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526226006276	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
526226006277	active site
526226006278	HIGH motif; other site
526226006279	nucleotide binding site [chemical binding]; other site
526226006280	Chlamydia-phage Chp2 scaffold (Chlamy_scaf); Region: Chlamy_scaf; cl11513
526226006281	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526226006282	active site
526226006283	KMSKS motif; other site
526226006284	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
526226006285	putative tRNA binding surface [nucleotide binding]; other site
526226006286	PAC2 family; Region: PAC2; pfam09754
526226006287	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
526226006288	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
526226006289	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
526226006290	substrate binding pocket [chemical binding]; other site
526226006291	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
526226006292	B12 binding site [chemical binding]; other site
526226006293	cobalt ligand [ion binding]; other site
526226006294	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
526226006295	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006296	putative DNA binding site [nucleotide binding]; other site
526226006297	dimerization interface [polypeptide binding]; other site
526226006298	putative Zn2+ binding site [ion binding]; other site
526226006299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226006300	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226006301	putative substrate translocation pore; other site
526226006302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226006303	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
526226006304	Predicted integral membrane protein [Function unknown]; Region: COG5542
526226006305	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226006306	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226006307	non-specific DNA binding site [nucleotide binding]; other site
526226006308	salt bridge; other site
526226006309	sequence-specific DNA binding site [nucleotide binding]; other site
526226006310	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
526226006311	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226006312	motif II; other site
526226006313	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
526226006314	homodimer interface [polypeptide binding]; other site
526226006315	putative metal binding site [ion binding]; other site
526226006316	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
526226006317	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
526226006318	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
526226006319	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526226006320	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
526226006321	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
526226006322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226006323	S-adenosylmethionine binding site [chemical binding]; other site
526226006324	proteasome ATPase; Region: pup_AAA; TIGR03689
526226006325	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226006326	Walker A motif; other site
526226006327	ATP binding site [chemical binding]; other site
526226006328	Walker B motif; other site
526226006329	arginine finger; other site
526226006330	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526226006331	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526226006332	phosphopeptide binding site; other site
526226006333	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526226006334	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526226006335	phosphopeptide binding site; other site
526226006336	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
526226006337	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
526226006338	Walker A/P-loop; other site
526226006339	ATP binding site [chemical binding]; other site
526226006340	Q-loop/lid; other site
526226006341	ABC transporter signature motif; other site
526226006342	Walker B; other site
526226006343	D-loop; other site
526226006344	H-loop/switch region; other site
526226006345	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526226006346	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
526226006347	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
526226006348	putative homodimer interface [polypeptide binding]; other site
526226006349	putative active site pocket [active]
526226006350	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
526226006351	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
526226006352	Pup-like protein; Region: Pup; cl05289
526226006353	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
526226006354	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
526226006355	active site
526226006356	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
526226006357	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
526226006358	active site
526226006359	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
526226006360	Predicted transcriptional regulator [Transcription]; Region: COG2378
526226006361	WYL domain; Region: WYL; pfam13280
526226006362	Predicted transcriptional regulator [Transcription]; Region: COG2378
526226006363	WYL domain; Region: WYL; pfam13280
526226006364	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
526226006365	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
526226006366	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
526226006367	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
526226006368	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226006369	ATP binding site [chemical binding]; other site
526226006370	putative Mg++ binding site [ion binding]; other site
526226006371	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226006372	nucleotide binding region [chemical binding]; other site
526226006373	ATP-binding site [chemical binding]; other site
526226006374	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
526226006375	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
526226006376	5'-3' exonuclease; Region: 53EXOc; smart00475
526226006377	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
526226006378	active site
526226006379	metal binding site 1 [ion binding]; metal-binding site
526226006380	putative 5' ssDNA interaction site; other site
526226006381	metal binding site 3; metal-binding site
526226006382	metal binding site 2 [ion binding]; metal-binding site
526226006383	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
526226006384	putative DNA binding site [nucleotide binding]; other site
526226006385	putative metal binding site [ion binding]; other site
526226006386	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
526226006387	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
526226006388	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
526226006389	active site
526226006390	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
526226006391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226006392	NAD(P) binding site [chemical binding]; other site
526226006393	active site
526226006394	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
526226006395	active site
526226006396	putative homodimer interface [polypeptide binding]; other site
526226006397	SAM binding site [chemical binding]; other site
526226006398	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
526226006399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226006400	S-adenosylmethionine binding site [chemical binding]; other site
526226006401	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
526226006402	active site
526226006403	SAM binding site [chemical binding]; other site
526226006404	homodimer interface [polypeptide binding]; other site
526226006405	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
526226006406	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
526226006407	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
526226006408	active site
526226006409	SAM binding site [chemical binding]; other site
526226006410	homodimer interface [polypeptide binding]; other site
526226006411	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
526226006412	active site
526226006413	SAM binding site [chemical binding]; other site
526226006414	homodimer interface [polypeptide binding]; other site
526226006415	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
526226006416	Precorrin-8X methylmutase; Region: CbiC; pfam02570
526226006417	precorrin-3B synthase; Region: CobG; TIGR02435
526226006418	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526226006419	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
526226006420	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
526226006421	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
526226006422	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
526226006423	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
526226006424	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526226006425	active site
526226006426	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
526226006427	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
526226006428	putative active site [active]
526226006429	catalytic triad [active]
526226006430	putative dimer interface [polypeptide binding]; other site
526226006431	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
526226006432	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526226006433	Ligand binding site; other site
526226006434	Putative Catalytic site; other site
526226006435	DXD motif; other site
526226006436	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
526226006437	hypothetical protein; Provisional; Region: PRK14013
526226006438	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526226006439	cyclase homology domain; Region: CHD; cd07302
526226006440	nucleotidyl binding site; other site
526226006441	metal binding site [ion binding]; metal-binding site
526226006442	dimer interface [polypeptide binding]; other site
526226006443	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
526226006444	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526226006445	active site
526226006446	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
526226006447	Domain of unknown function (DUF385); Region: DUF385; cl04387
526226006448	Predicted dehydrogenase [General function prediction only]; Region: COG0579
526226006449	hydroxyglutarate oxidase; Provisional; Region: PRK11728
526226006450	PGAP1-like protein; Region: PGAP1; pfam07819
526226006451	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
526226006452	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
526226006453	active site
526226006454	substrate binding site [chemical binding]; other site
526226006455	metal binding site [ion binding]; metal-binding site
526226006456	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226006457	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526226006458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226006459	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
526226006460	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226006461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226006462	Walker A/P-loop; other site
526226006463	ATP binding site [chemical binding]; other site
526226006464	Q-loop/lid; other site
526226006465	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
526226006466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226006467	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
526226006468	Walker A/P-loop; other site
526226006469	ATP binding site [chemical binding]; other site
526226006470	Q-loop/lid; other site
526226006471	ABC transporter signature motif; other site
526226006472	Walker B; other site
526226006473	D-loop; other site
526226006474	H-loop/switch region; other site
526226006475	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
526226006476	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226006477	Cytochrome P450; Region: p450; cl12078
526226006478	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226006479	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
526226006480	Predicted transcriptional regulators [Transcription]; Region: COG1695
526226006481	Transcriptional regulator PadR-like family; Region: PadR; cl17335
526226006482	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
526226006483	SnoaL-like domain; Region: SnoaL_2; pfam12680
526226006484	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
526226006485	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526226006486	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226006487	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
526226006488	putative dimerization interface [polypeptide binding]; other site
526226006489	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
526226006490	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
526226006491	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
526226006492	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
526226006493	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
526226006494	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
526226006495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
526226006496	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
526226006497	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
526226006498	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
526226006499	Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480
526226006500	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
526226006501	active site
526226006502	catalytic triad [active]
526226006503	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526226006504	Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949
526226006505	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
526226006506	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
526226006507	tetramer interface [polypeptide binding]; other site
526226006508	heme binding pocket [chemical binding]; other site
526226006509	NADPH binding site [chemical binding]; other site
526226006510	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
526226006511	Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
526226006512	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006513	dimerization interface [polypeptide binding]; other site
526226006514	putative DNA binding site [nucleotide binding]; other site
526226006515	putative Zn2+ binding site [ion binding]; other site
526226006516	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
526226006517	putative hydrophobic ligand binding site [chemical binding]; other site
526226006518	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
526226006519	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526226006520	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526226006521	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
526226006522	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526226006523	carboxyltransferase (CT) interaction site; other site
526226006524	biotinylation site [posttranslational modification]; other site
526226006525	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
526226006526	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
526226006527	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
526226006528	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226006529	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
526226006530	acyl-activating enzyme (AAE) consensus motif; other site
526226006531	acyl-activating enzyme (AAE) consensus motif; other site
526226006532	putative AMP binding site [chemical binding]; other site
526226006533	putative active site [active]
526226006534	putative CoA binding site [chemical binding]; other site
526226006535	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
526226006536	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
526226006537	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226006538	active site
526226006539	motif I; other site
526226006540	motif II; other site
526226006541	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526226006542	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
526226006543	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
526226006544	putative active site [active]
526226006545	putative metal binding site [ion binding]; other site
526226006546	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
526226006547	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
526226006548	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
526226006549	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
526226006550	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
526226006551	putative active site [active]
526226006552	putative active site [active]
526226006553	catalytic site [active]
526226006554	catalytic site [active]
526226006555	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
526226006556	putative active site [active]
526226006557	catalytic site [active]
526226006558	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
526226006559	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
526226006560	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226006561	acyl-CoA synthetase; Validated; Region: PRK06188
526226006562	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226006563	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
526226006564	acyl-activating enzyme (AAE) consensus motif; other site
526226006565	putative AMP binding site [chemical binding]; other site
526226006566	putative active site [active]
526226006567	putative CoA binding site [chemical binding]; other site
526226006568	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526226006569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226006570	ATP binding site [chemical binding]; other site
526226006571	Mg2+ binding site [ion binding]; other site
526226006572	G-X-G motif; other site
526226006573	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226006574	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226006575	enoyl-CoA hydratase; Provisional; Region: PRK07509
526226006576	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226006577	substrate binding site [chemical binding]; other site
526226006578	oxyanion hole (OAH) forming residues; other site
526226006579	trimer interface [polypeptide binding]; other site
526226006580	Hemerythrin-like domain; Region: Hr-like; cd12108
526226006581	Dienelactone hydrolase family; Region: DLH; pfam01738
526226006582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226006583	putative substrate translocation pore; other site
526226006584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226006585	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
526226006586	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
526226006587	active site
526226006588	metal binding site [ion binding]; metal-binding site
526226006589	nudix motif; other site
526226006590	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
526226006591	active site lid residues [active]
526226006592	substrate binding pocket [chemical binding]; other site
526226006593	catalytic residues [active]
526226006594	substrate-Mg2+ binding site; other site
526226006595	aspartate-rich region 1; other site
526226006596	aspartate-rich region 2; other site
526226006597	phytoene desaturase; Region: crtI_fam; TIGR02734
526226006598	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226006599	phytoene desaturase; Region: crtI_fam; TIGR02734
526226006600	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526226006601	active site
526226006602	Protein of unknown function (DUF422); Region: DUF422; cl00991
526226006603	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
526226006604	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
526226006605	substrate binding pocket [chemical binding]; other site
526226006606	chain length determination region; other site
526226006607	substrate-Mg2+ binding site; other site
526226006608	catalytic residues [active]
526226006609	aspartate-rich region 1; other site
526226006610	active site lid residues [active]
526226006611	aspartate-rich region 2; other site
526226006612	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226006613	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226006614	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526226006615	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226006616	substrate binding site [chemical binding]; other site
526226006617	oxyanion hole (OAH) forming residues; other site
526226006618	trimer interface [polypeptide binding]; other site
526226006619	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
526226006620	putative dimer interface [polypeptide binding]; other site
526226006621	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226006622	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226006623	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526226006624	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
526226006625	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
526226006626	putative hydrophobic ligand binding site [chemical binding]; other site
526226006627	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
526226006628	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
526226006629	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526226006630	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526226006631	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526226006632	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
526226006633	putative NAD(P) binding site [chemical binding]; other site
526226006634	CsbD-like; Region: CsbD; pfam05532
526226006635	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226006636	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226006637	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
526226006638	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526226006639	RibD C-terminal domain; Region: RibD_C; cl17279
526226006640	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226006641	hydrophobic ligand binding site; other site
526226006642	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
526226006643	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226006644	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226006645	Uncharacterized conserved protein [Function unknown]; Region: COG4095
526226006646	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
526226006647	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226006648	NAD(P) binding site [chemical binding]; other site
526226006649	active site
526226006650	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006651	dimerization interface [polypeptide binding]; other site
526226006652	putative DNA binding site [nucleotide binding]; other site
526226006653	putative Zn2+ binding site [ion binding]; other site
526226006654	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226006655	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
526226006656	active site
526226006657	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
526226006658	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
526226006659	active site
526226006660	catalytic residues [active]
526226006661	DNA binding site [nucleotide binding]
526226006662	Int/Topo IB signature motif; other site
526226006663	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
526226006664	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226006665	active site
526226006666	DNA binding site [nucleotide binding]
526226006667	Int/Topo IB signature motif; other site
526226006668	Transposase; Region: HTH_Tnp_1; pfam01527
526226006669	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
526226006670	Transposase; Region: HTH_Tnp_1; cl17663
526226006671	putative transposase OrfB; Reviewed; Region: PHA02517
526226006672	HTH-like domain; Region: HTH_21; pfam13276
526226006673	Integrase core domain; Region: rve; pfam00665
526226006674	Integrase core domain; Region: rve_3; pfam13683
526226006675	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
526226006676	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
526226006677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
526226006678	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526226006679	Transposase, Mutator family; Region: Transposase_mut; pfam00872
526226006680	MULE transposase domain; Region: MULE; pfam10551
526226006681	Domain of unknown function (DUF305); Region: DUF305; pfam03713
526226006682	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226006683	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226006684	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
526226006685	putative homodimer interface [polypeptide binding]; other site
526226006686	putative homotetramer interface [polypeptide binding]; other site
526226006687	putative allosteric switch controlling residues; other site
526226006688	putative metal binding site [ion binding]; other site
526226006689	putative homodimer-homodimer interface [polypeptide binding]; other site
526226006690	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
526226006691	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226006692	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526226006693	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
526226006694	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526226006695	metal-binding site [ion binding]
526226006696	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226006697	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526226006698	metal-binding site [ion binding]
526226006699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226006700	putative substrate translocation pore; other site
526226006701	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
526226006702	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
526226006703	dimer interface [polypeptide binding]; other site
526226006704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226006705	catalytic residue [active]
526226006706	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226006707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226006708	active site
526226006709	phosphorylation site [posttranslational modification]
526226006710	intermolecular recognition site; other site
526226006711	dimerization interface [polypeptide binding]; other site
526226006712	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226006713	DNA binding site [nucleotide binding]
526226006714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226006715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226006716	dimer interface [polypeptide binding]; other site
526226006717	phosphorylation site [posttranslational modification]
526226006718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226006719	ATP binding site [chemical binding]; other site
526226006720	Mg2+ binding site [ion binding]; other site
526226006721	G-X-G motif; other site
526226006722	Penicillinase repressor; Region: Pencillinase_R; pfam03965
526226006723	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006724	dimerization interface [polypeptide binding]; other site
526226006725	putative DNA binding site [nucleotide binding]; other site
526226006726	putative Zn2+ binding site [ion binding]; other site
526226006727	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
526226006728	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226006729	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526226006730	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
526226006731	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
526226006732	putative transposase OrfB; Reviewed; Region: PHA02517
526226006733	HTH-like domain; Region: HTH_21; pfam13276
526226006734	Integrase core domain; Region: rve; pfam00665
526226006735	Integrase core domain; Region: rve_3; pfam13683
526226006736	Transposase; Region: HTH_Tnp_1; cl17663
526226006737	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
526226006738	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
526226006739	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526226006740	metal-binding site [ion binding]
526226006741	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226006742	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526226006743	Penicillinase repressor; Region: Pencillinase_R; pfam03965
526226006744	Peptidase family M48; Region: Peptidase_M48; cl12018
526226006745	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
526226006746	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
526226006747	D-pathway; other site
526226006748	Putative ubiquinol binding site [chemical binding]; other site
526226006749	Low-spin heme (heme b) binding site [chemical binding]; other site
526226006750	Putative water exit pathway; other site
526226006751	Binuclear center (heme o3/CuB) [ion binding]; other site
526226006752	K-pathway; other site
526226006753	Putative proton exit pathway; other site
526226006754	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226006755	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226006756	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526226006757	catalytic residues [active]
526226006758	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
526226006759	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
526226006760	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
526226006761	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
526226006762	putative active site [active]
526226006763	redox center [active]
526226006764	Thioredoxin; Region: Thioredoxin_4; pfam13462
526226006765	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
526226006766	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
526226006767	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
526226006768	putative active site [active]
526226006769	catalytic triad [active]
526226006770	putative dimer interface [polypeptide binding]; other site
526226006771	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
526226006772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
526226006773	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
526226006774	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526226006775	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
526226006776	ResB-like family; Region: ResB; pfam05140
526226006777	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
526226006778	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226006779	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226006780	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526226006781	cyclase homology domain; Region: CHD; cd07302
526226006782	nucleotidyl binding site; other site
526226006783	metal binding site [ion binding]; metal-binding site
526226006784	dimer interface [polypeptide binding]; other site
526226006785	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
526226006786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226006787	S-adenosylmethionine binding site [chemical binding]; other site
526226006788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226006789	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226006790	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
526226006791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
526226006792	Transposase; Region: DEDD_Tnp_IS110; pfam01548
526226006793	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
526226006794	Transposase, Mutator family; Region: Transposase_mut; pfam00872
526226006795	MULE transposase domain; Region: MULE; pfam10551
526226006796	Predicted helicase [General function prediction only]; Region: COG4889
526226006797	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
526226006798	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226006799	ATP binding site [chemical binding]; other site
526226006800	putative Mg++ binding site [ion binding]; other site
526226006801	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
526226006802	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
526226006803	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
526226006804	alkylmercury lyase; Provisional; Region: PRK13239
526226006805	Alkylmercury lyase; Region: MerB; pfam03243
526226006806	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526226006807	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526226006808	DNA binding residues [nucleotide binding]
526226006809	mercuric reductase; Region: MerA; TIGR02053
526226006810	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226006811	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526226006812	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006813	dimerization interface [polypeptide binding]; other site
526226006814	putative DNA binding site [nucleotide binding]; other site
526226006815	putative Zn2+ binding site [ion binding]; other site
526226006816	MMPL family; Region: MMPL; pfam03176
526226006817	MMPL family; Region: MMPL; pfam03176
526226006818	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006819	dimerization interface [polypeptide binding]; other site
526226006820	putative DNA binding site [nucleotide binding]; other site
526226006821	putative Zn2+ binding site [ion binding]; other site
526226006822	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
526226006823	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226006824	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526226006825	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
526226006826	Transposase; Region: HTH_Tnp_1; cl17663
526226006827	putative transposase OrfB; Reviewed; Region: PHA02517
526226006828	HTH-like domain; Region: HTH_21; pfam13276
526226006829	Integrase core domain; Region: rve; pfam00665
526226006830	Integrase core domain; Region: rve_3; pfam13683
526226006831	Cadmium resistance transporter; Region: Cad; pfam03596
526226006832	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226006833	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226006834	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
526226006835	ResB-like family; Region: ResB; pfam05140
526226006836	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
526226006837	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
526226006838	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
526226006839	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526226006840	Thioredoxin; Region: Thioredoxin_4; pfam13462
526226006841	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
526226006842	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
526226006843	putative active site [active]
526226006844	redox center [active]
526226006845	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
526226006846	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226006847	Walker A motif; other site
526226006848	ATP binding site [chemical binding]; other site
526226006849	Walker B motif; other site
526226006850	Transposase; Region: HTH_Tnp_1; cl17663
526226006851	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
526226006852	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226006853	active site
526226006854	DNA binding site [nucleotide binding]
526226006855	Int/Topo IB signature motif; other site
526226006856	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
526226006857	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
526226006858	active site
526226006859	catalytic residues [active]
526226006860	DNA binding site [nucleotide binding]
526226006861	Int/Topo IB signature motif; other site
526226006862	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
526226006863	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
526226006864	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
526226006865	catalytic residues [active]
526226006866	Helicase associated domain; Region: HA; pfam03457
526226006867	Helicase associated domain; Region: HA; pfam03457
526226006868	Helicase associated domain; Region: HA; pfam03457
526226006869	Helicase associated domain; Region: HA; pfam03457
526226006870	Helicase associated domain; Region: HA; pfam03457
526226006871	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006872	dimerization interface [polypeptide binding]; other site
526226006873	putative DNA binding site [nucleotide binding]; other site
526226006874	putative Zn2+ binding site [ion binding]; other site
526226006875	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
526226006876	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226006877	putative metal binding site [ion binding]; other site
526226006878	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526226006879	Low molecular weight phosphatase family; Region: LMWPc; cl00105
526226006880	active site
526226006881	Low molecular weight phosphatase family; Region: LMWPc; cd00115
526226006882	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526226006883	active site
526226006884	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
526226006885	Low molecular weight phosphatase family; Region: LMWPc; cl00105
526226006886	active site
526226006887	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
526226006888	arsenical-resistance protein; Region: acr3; TIGR00832
526226006889	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006890	dimerization interface [polypeptide binding]; other site
526226006891	putative DNA binding site [nucleotide binding]; other site
526226006892	putative Zn2+ binding site [ion binding]; other site
526226006893	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
526226006894	active site
526226006895	NTP binding site [chemical binding]; other site
526226006896	metal binding triad [ion binding]; metal-binding site
526226006897	antibiotic binding site [chemical binding]; other site
526226006898	Predicted ATPase [General function prediction only]; Region: COG3911
526226006899	AAA domain; Region: AAA_28; pfam13521
526226006900	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
526226006901	putative dimer interface [polypeptide binding]; other site
526226006902	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226006903	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226006904	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006905	dimerization interface [polypeptide binding]; other site
526226006906	putative DNA binding site [nucleotide binding]; other site
526226006907	putative Zn2+ binding site [ion binding]; other site
526226006908	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
526226006909	Sodium Bile acid symporter family; Region: SBF; cl17470
526226006910	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
526226006911	putative dimer interface [polypeptide binding]; other site
526226006912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226006913	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226006914	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
526226006915	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
526226006916	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
526226006917	ligand binding site; other site
526226006918	oligomer interface; other site
526226006919	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
526226006920	dimer interface [polypeptide binding]; other site
526226006921	N-terminal domain interface [polypeptide binding]; other site
526226006922	sulfate 1 binding site; other site
526226006923	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226006924	Cytochrome P450; Region: p450; cl12078
526226006925	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226006926	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226006927	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
526226006928	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
526226006929	GXWXG protein; Region: GXWXG; pfam14231
526226006930	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
526226006931	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226006932	Coenzyme A binding pocket [chemical binding]; other site
526226006933	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
526226006934	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
526226006935	metal binding site 2 [ion binding]; metal-binding site
526226006936	putative DNA binding helix; other site
526226006937	metal binding site 1 [ion binding]; metal-binding site
526226006938	dimer interface [polypeptide binding]; other site
526226006939	structural Zn2+ binding site [ion binding]; other site
526226006940	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
526226006941	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
526226006942	heme binding site [chemical binding]; other site
526226006943	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
526226006944	hypothetical protein; Validated; Region: PRK07198
526226006945	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
526226006946	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
526226006947	dimerization interface [polypeptide binding]; other site
526226006948	active site
526226006949	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
526226006950	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226006951	active site
526226006952	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
526226006953	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
526226006954	Walker A/P-loop; other site
526226006955	ATP binding site [chemical binding]; other site
526226006956	Q-loop/lid; other site
526226006957	ABC transporter signature motif; other site
526226006958	Walker B; other site
526226006959	D-loop; other site
526226006960	H-loop/switch region; other site
526226006961	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
526226006962	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226006963	dimerization interface [polypeptide binding]; other site
526226006964	putative DNA binding site [nucleotide binding]; other site
526226006965	putative Zn2+ binding site [ion binding]; other site
526226006966	CAAX protease self-immunity; Region: Abi; pfam02517
526226006967	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226006968	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226006969	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526226006970	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526226006971	Walker A/P-loop; other site
526226006972	ATP binding site [chemical binding]; other site
526226006973	Q-loop/lid; other site
526226006974	ABC transporter signature motif; other site
526226006975	Walker B; other site
526226006976	D-loop; other site
526226006977	H-loop/switch region; other site
526226006978	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
526226006979	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
526226006980	Walker A/P-loop; other site
526226006981	ATP binding site [chemical binding]; other site
526226006982	Q-loop/lid; other site
526226006983	ABC transporter signature motif; other site
526226006984	Walker B; other site
526226006985	D-loop; other site
526226006986	H-loop/switch region; other site
526226006987	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526226006988	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526226006989	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
526226006990	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
526226006991	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
526226006992	homotetramer interface [polypeptide binding]; other site
526226006993	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526226006994	NAD binding site [chemical binding]; other site
526226006995	homodimer interface [polypeptide binding]; other site
526226006996	active site
526226006997	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
526226006998	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226006999	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226007000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226007001	active site
526226007002	phosphorylation site [posttranslational modification]
526226007003	intermolecular recognition site; other site
526226007004	dimerization interface [polypeptide binding]; other site
526226007005	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226007006	DNA binding residues [nucleotide binding]
526226007007	dimerization interface [polypeptide binding]; other site
526226007008	Histidine kinase; Region: HisKA_3; pfam07730
526226007009	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526226007010	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
526226007011	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226007012	Walker A/P-loop; other site
526226007013	ATP binding site [chemical binding]; other site
526226007014	Q-loop/lid; other site
526226007015	ABC transporter signature motif; other site
526226007016	Walker B; other site
526226007017	D-loop; other site
526226007018	H-loop/switch region; other site
526226007019	Predicted membrane protein [Function unknown]; Region: COG4425
526226007020	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
526226007021	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
526226007022	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226007023	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526226007024	CoenzymeA binding site [chemical binding]; other site
526226007025	subunit interaction site [polypeptide binding]; other site
526226007026	PHB binding site; other site
526226007027	enoyl-CoA hydratase; Provisional; Region: PRK06142
526226007028	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226007029	substrate binding site [chemical binding]; other site
526226007030	oxyanion hole (OAH) forming residues; other site
526226007031	trimer interface [polypeptide binding]; other site
526226007032	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
526226007033	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
526226007034	heat shock protein 90; Provisional; Region: PRK05218
526226007035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226007036	ATP binding site [chemical binding]; other site
526226007037	Mg2+ binding site [ion binding]; other site
526226007038	G-X-G motif; other site
526226007039	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
526226007040	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
526226007041	AAA domain; Region: AAA_30; pfam13604
526226007042	Family description; Region: UvrD_C_2; pfam13538
526226007043	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
526226007044	Part of AAA domain; Region: AAA_19; pfam13245
526226007045	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
526226007046	Family description; Region: UvrD_C_2; pfam13538
526226007047	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
526226007048	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
526226007049	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
526226007050	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
526226007051	active site
526226007052	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226007053	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526226007054	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
526226007055	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226007056	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226007057	lysine transporter; Provisional; Region: PRK10836
526226007058	UreD urease accessory protein; Region: UreD; cl00530
526226007059	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526226007060	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
526226007061	urease subunit alpha; Reviewed; Region: ureC; PRK13206
526226007062	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
526226007063	subunit interactions [polypeptide binding]; other site
526226007064	active site
526226007065	flap region; other site
526226007066	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
526226007067	gamma-beta subunit interface [polypeptide binding]; other site
526226007068	alpha-beta subunit interface [polypeptide binding]; other site
526226007069	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
526226007070	alpha-gamma subunit interface [polypeptide binding]; other site
526226007071	beta-gamma subunit interface [polypeptide binding]; other site
526226007072	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
526226007073	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526226007074	CoenzymeA binding site [chemical binding]; other site
526226007075	subunit interaction site [polypeptide binding]; other site
526226007076	PHB binding site; other site
526226007077	Predicted transcriptional regulator [Transcription]; Region: COG3682
526226007078	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
526226007079	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
526226007080	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
526226007081	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
526226007082	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
526226007083	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526226007084	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
526226007085	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
526226007086	active site
526226007087	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526226007088	Domain of unknown function DUF21; Region: DUF21; pfam01595
526226007089	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526226007090	Transporter associated domain; Region: CorC_HlyC; smart01091
526226007091	Domain of unknown function DUF21; Region: DUF21; pfam01595
526226007092	FOG: CBS domain [General function prediction only]; Region: COG0517
526226007093	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526226007094	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
526226007095	active site
526226007096	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
526226007097	glycine dehydrogenase; Provisional; Region: PRK05367
526226007098	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
526226007099	tetramer interface [polypeptide binding]; other site
526226007100	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226007101	catalytic residue [active]
526226007102	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
526226007103	tetramer interface [polypeptide binding]; other site
526226007104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226007105	catalytic residue [active]
526226007106	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526226007107	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
526226007108	DNA binding residues [nucleotide binding]
526226007109	putative dimer interface [polypeptide binding]; other site
526226007110	oxidoreductase; Provisional; Region: PRK06196
526226007111	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226007112	NAD(P) binding site [chemical binding]; other site
526226007113	active site
526226007114	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
526226007115	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526226007116	DNA binding residues [nucleotide binding]
526226007117	putative dimer interface [polypeptide binding]; other site
526226007118	Bifunctional nuclease; Region: DNase-RNase; pfam02577
526226007119	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
526226007120	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526226007121	DNA binding residues [nucleotide binding]
526226007122	dimer interface [polypeptide binding]; other site
526226007123	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
526226007124	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
526226007125	phosphopeptide binding site; other site
526226007126	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
526226007127	lipoyl attachment site [posttranslational modification]; other site
526226007128	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
526226007129	SecA DEAD-like domain; Region: SecA_DEAD; smart00957
526226007130	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
526226007131	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226007132	nucleotide binding region [chemical binding]; other site
526226007133	ATP-binding site [chemical binding]; other site
526226007134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
526226007135	Transposase; Region: DDE_Tnp_ISL3; pfam01610
526226007136	META domain; Region: META; pfam03724
526226007137	malate dehydrogenase; Provisional; Region: PRK05442
526226007138	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
526226007139	NAD(P) binding site [chemical binding]; other site
526226007140	LDH/MDH dimer interface [polypeptide binding]; other site
526226007141	substrate binding site [chemical binding]; other site
526226007142	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
526226007143	Protein of unknown function (DUF503); Region: DUF503; pfam04456
526226007144	pyruvate dehydrogenase; Provisional; Region: PRK09124
526226007145	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
526226007146	PYR/PP interface [polypeptide binding]; other site
526226007147	tetramer interface [polypeptide binding]; other site
526226007148	dimer interface [polypeptide binding]; other site
526226007149	TPP binding site [chemical binding]; other site
526226007150	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526226007151	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
526226007152	TPP-binding site [chemical binding]; other site
526226007153	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
526226007154	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
526226007155	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
526226007156	shikimate binding site; other site
526226007157	NAD(P) binding site [chemical binding]; other site
526226007158	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
526226007159	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226007160	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
526226007161	beta-galactosidase; Region: BGL; TIGR03356
526226007162	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
526226007163	substrate binding site [chemical binding]; other site
526226007164	dimer interface [polypeptide binding]; other site
526226007165	ATP binding site [chemical binding]; other site
526226007166	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
526226007167	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
526226007168	NAD(P) binding site [chemical binding]; other site
526226007169	catalytic residues [active]
526226007170	Domain of unknown function (DUF385); Region: DUF385; pfam04075
526226007171	Transposase; Region: HTH_Tnp_1; cl17663
526226007172	putative transposase OrfB; Reviewed; Region: PHA02517
526226007173	HTH-like domain; Region: HTH_21; pfam13276
526226007174	Integrase core domain; Region: rve; pfam00665
526226007175	Integrase core domain; Region: rve_3; pfam13683
526226007176	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226007177	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226007178	active site
526226007179	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
526226007180	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
526226007181	DNA binding residues [nucleotide binding]
526226007182	dimer interface [polypeptide binding]; other site
526226007183	[2Fe-2S] cluster binding site [ion binding]; other site
526226007184	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
526226007185	Transposase; Region: HTH_Tnp_1; cl17663
526226007186	putative transposase OrfB; Reviewed; Region: PHA02517
526226007187	HTH-like domain; Region: HTH_21; pfam13276
526226007188	Integrase core domain; Region: rve; pfam00665
526226007189	Integrase core domain; Region: rve_3; pfam13683
526226007190	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
526226007191	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
526226007192	GTP-binding protein Der; Reviewed; Region: PRK03003
526226007193	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
526226007194	G1 box; other site
526226007195	GTP/Mg2+ binding site [chemical binding]; other site
526226007196	Switch I region; other site
526226007197	G2 box; other site
526226007198	Switch II region; other site
526226007199	G3 box; other site
526226007200	G4 box; other site
526226007201	G5 box; other site
526226007202	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
526226007203	G1 box; other site
526226007204	GTP/Mg2+ binding site [chemical binding]; other site
526226007205	Switch I region; other site
526226007206	G2 box; other site
526226007207	G3 box; other site
526226007208	Switch II region; other site
526226007209	G4 box; other site
526226007210	G5 box; other site
526226007211	cytidylate kinase; Provisional; Region: cmk; PRK00023
526226007212	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
526226007213	CMP-binding site; other site
526226007214	The sites determining sugar specificity; other site
526226007215	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
526226007216	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526226007217	RNA binding surface [nucleotide binding]; other site
526226007218	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
526226007219	active site
526226007220	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
526226007221	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
526226007222	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226007223	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
526226007224	P-loop; other site
526226007225	Magnesium ion binding site [ion binding]; other site
526226007226	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226007227	Magnesium ion binding site [ion binding]; other site
526226007228	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
526226007229	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226007230	active site
526226007231	DNA binding site [nucleotide binding]
526226007232	Int/Topo IB signature motif; other site
526226007233	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
526226007234	dimer interface [polypeptide binding]; other site
526226007235	ADP-ribose binding site [chemical binding]; other site
526226007236	active site
526226007237	nudix motif; other site
526226007238	metal binding site [ion binding]; metal-binding site
526226007239	CTP synthetase; Validated; Region: pyrG; PRK05380
526226007240	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
526226007241	Catalytic site [active]
526226007242	active site
526226007243	UTP binding site [chemical binding]; other site
526226007244	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
526226007245	active site
526226007246	putative oxyanion hole; other site
526226007247	catalytic triad [active]
526226007248	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
526226007249	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
526226007250	Thiamine pyrophosphokinase; Region: TPK; cl08415
526226007251	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
526226007252	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
526226007253	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
526226007254	Walker A/P-loop; other site
526226007255	ATP binding site [chemical binding]; other site
526226007256	Q-loop/lid; other site
526226007257	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
526226007258	ABC transporter signature motif; other site
526226007259	Walker B; other site
526226007260	D-loop; other site
526226007261	H-loop/switch region; other site
526226007262	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
526226007263	ATP-NAD kinase; Region: NAD_kinase; pfam01513
526226007264	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
526226007265	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
526226007266	RNA binding surface [nucleotide binding]; other site
526226007267	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
526226007268	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
526226007269	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
526226007270	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
526226007271	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
526226007272	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
526226007273	active site
526226007274	HIGH motif; other site
526226007275	dimer interface [polypeptide binding]; other site
526226007276	KMSKS motif; other site
526226007277	S4 RNA-binding domain; Region: S4; smart00363
526226007278	RNA binding surface [nucleotide binding]; other site
526226007279	Uncharacterized conserved protein [Function unknown]; Region: COG2835
526226007280	acyl-CoA synthetase; Validated; Region: PRK07868
526226007281	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226007282	acyl-activating enzyme (AAE) consensus motif; other site
526226007283	AMP binding site [chemical binding]; other site
526226007284	active site
526226007285	CoA binding site [chemical binding]; other site
526226007286	argininosuccinate lyase; Provisional; Region: PRK00855
526226007287	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
526226007288	active sites [active]
526226007289	tetramer interface [polypeptide binding]; other site
526226007290	argininosuccinate synthase; Provisional; Region: PRK13820
526226007291	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
526226007292	ANP binding site [chemical binding]; other site
526226007293	Substrate Binding Site II [chemical binding]; other site
526226007294	Substrate Binding Site I [chemical binding]; other site
526226007295	Arginine repressor [Transcription]; Region: ArgR; COG1438
526226007296	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
526226007297	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
526226007298	ornithine carbamoyltransferase; Provisional; Region: PRK00779
526226007299	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
526226007300	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
526226007301	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
526226007302	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526226007303	inhibitor-cofactor binding pocket; inhibition site
526226007304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226007305	catalytic residue [active]
526226007306	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
526226007307	homohexameric interface [polypeptide binding]; other site
526226007308	nucleotide binding site [chemical binding]; other site
526226007309	N-acetyl-L-glutamate binding site [chemical binding]; other site
526226007310	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
526226007311	heterotetramer interface [polypeptide binding]; other site
526226007312	active site pocket [active]
526226007313	cleavage site
526226007314	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
526226007315	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
526226007316	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
526226007317	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
526226007318	putative tRNA-binding site [nucleotide binding]; other site
526226007319	B3/4 domain; Region: B3_4; pfam03483
526226007320	tRNA synthetase B5 domain; Region: B5; smart00874
526226007321	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
526226007322	dimer interface [polypeptide binding]; other site
526226007323	motif 1; other site
526226007324	motif 3; other site
526226007325	motif 2; other site
526226007326	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
526226007327	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
526226007328	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
526226007329	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
526226007330	dimer interface [polypeptide binding]; other site
526226007331	motif 1; other site
526226007332	active site
526226007333	motif 2; other site
526226007334	motif 3; other site
526226007335	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
526226007336	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
526226007337	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
526226007338	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
526226007339	RNA binding site [nucleotide binding]; other site
526226007340	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
526226007341	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
526226007342	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526226007343	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
526226007344	23S rRNA binding site [nucleotide binding]; other site
526226007345	L21 binding site [polypeptide binding]; other site
526226007346	L13 binding site [polypeptide binding]; other site
526226007347	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
526226007348	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
526226007349	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
526226007350	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
526226007351	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226007352	ABC transporter signature motif; other site
526226007353	Walker B; other site
526226007354	D-loop; other site
526226007355	H-loop/switch region; other site
526226007356	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
526226007357	Cupin domain; Region: Cupin_2; cl17218
526226007358	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
526226007359	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226007360	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
526226007361	DoxX; Region: DoxX; pfam07681
526226007362	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
526226007363	Part of AAA domain; Region: AAA_19; pfam13245
526226007364	Family description; Region: UvrD_C_2; pfam13538
526226007365	Isochorismatase family; Region: Isochorismatase; pfam00857
526226007366	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
526226007367	catalytic triad [active]
526226007368	conserved cis-peptide bond; other site
526226007369	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
526226007370	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
526226007371	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
526226007372	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
526226007373	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
526226007374	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526226007375	CoA-transferase family III; Region: CoA_transf_3; pfam02515
526226007376	Transcriptional regulators [Transcription]; Region: FadR; COG2186
526226007377	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226007378	DNA-binding site [nucleotide binding]; DNA binding site
526226007379	FCD domain; Region: FCD; pfam07729
526226007380	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
526226007381	active site
526226007382	catalytic residues [active]
526226007383	metal binding site [ion binding]; metal-binding site
526226007384	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226007385	Ligand Binding Site [chemical binding]; other site
526226007386	excinuclease ABC subunit B; Provisional; Region: PRK05298
526226007387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226007388	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226007389	nucleotide binding region [chemical binding]; other site
526226007390	ATP-binding site [chemical binding]; other site
526226007391	Ultra-violet resistance protein B; Region: UvrB; pfam12344
526226007392	UvrB/uvrC motif; Region: UVR; pfam02151
526226007393	Protein of unknown function (DUF402); Region: DUF402; cl00979
526226007394	hydrophobic ligand binding site; other site
526226007395	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226007396	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
526226007397	dephospho-CoA kinase; Region: TIGR00152
526226007398	CoA-binding site [chemical binding]; other site
526226007399	ATP-binding [chemical binding]; other site
526226007400	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
526226007401	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
526226007402	RNA binding site [nucleotide binding]; other site
526226007403	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
526226007404	RNA binding site [nucleotide binding]; other site
526226007405	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
526226007406	RNA binding site [nucleotide binding]; other site
526226007407	S1 RNA binding domain; Region: S1; pfam00575
526226007408	RNA binding site [nucleotide binding]; other site
526226007409	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
526226007410	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
526226007411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226007412	S-adenosylmethionine binding site [chemical binding]; other site
526226007413	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
526226007414	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526226007415	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226007416	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226007417	active site
526226007418	ATP binding site [chemical binding]; other site
526226007419	substrate binding site [chemical binding]; other site
526226007420	activation loop (A-loop); other site
526226007421	ERCC4 domain; Region: ERCC4; smart00891
526226007422	Lsr2; Region: Lsr2; pfam11774
526226007423	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226007424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226007425	active site
526226007426	phosphorylation site [posttranslational modification]
526226007427	intermolecular recognition site; other site
526226007428	dimerization interface [polypeptide binding]; other site
526226007429	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226007430	DNA binding residues [nucleotide binding]
526226007431	dimerization interface [polypeptide binding]; other site
526226007432	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
526226007433	Histidine kinase; Region: HisKA_3; pfam07730
526226007434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226007435	ATP binding site [chemical binding]; other site
526226007436	Mg2+ binding site [ion binding]; other site
526226007437	G-X-G motif; other site
526226007438	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
526226007439	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526226007440	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
526226007441	Walker A/P-loop; other site
526226007442	ATP binding site [chemical binding]; other site
526226007443	Q-loop/lid; other site
526226007444	ABC transporter signature motif; other site
526226007445	Walker B; other site
526226007446	D-loop; other site
526226007447	H-loop/switch region; other site
526226007448	tartrate dehydrogenase; Provisional; Region: PRK08194
526226007449	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
526226007450	DNA polymerase I; Provisional; Region: PRK05755
526226007451	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
526226007452	active site
526226007453	metal binding site 1 [ion binding]; metal-binding site
526226007454	putative 5' ssDNA interaction site; other site
526226007455	metal binding site 3; metal-binding site
526226007456	metal binding site 2 [ion binding]; metal-binding site
526226007457	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
526226007458	putative DNA binding site [nucleotide binding]; other site
526226007459	putative metal binding site [ion binding]; other site
526226007460	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
526226007461	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
526226007462	active site
526226007463	DNA binding site [nucleotide binding]
526226007464	catalytic site [active]
526226007465	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526226007466	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
526226007467	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526226007468	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
526226007469	TM-ABC transporter signature motif; other site
526226007470	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
526226007471	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
526226007472	TM-ABC transporter signature motif; other site
526226007473	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
526226007474	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
526226007475	Walker A/P-loop; other site
526226007476	ATP binding site [chemical binding]; other site
526226007477	Q-loop/lid; other site
526226007478	ABC transporter signature motif; other site
526226007479	Walker B; other site
526226007480	D-loop; other site
526226007481	H-loop/switch region; other site
526226007482	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
526226007483	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
526226007484	Walker A/P-loop; other site
526226007485	ATP binding site [chemical binding]; other site
526226007486	Q-loop/lid; other site
526226007487	ABC transporter signature motif; other site
526226007488	Walker B; other site
526226007489	D-loop; other site
526226007490	H-loop/switch region; other site
526226007491	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
526226007492	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526226007493	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
526226007494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226007495	active site
526226007496	phosphorylation site [posttranslational modification]
526226007497	intermolecular recognition site; other site
526226007498	dimerization interface [polypeptide binding]; other site
526226007499	ANTAR domain; Region: ANTAR; pfam03861
526226007500	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226007501	non-specific DNA binding site [nucleotide binding]; other site
526226007502	salt bridge; other site
526226007503	sequence-specific DNA binding site [nucleotide binding]; other site
526226007504	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226007505	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226007506	Transcriptional regulators [Transcription]; Region: FadR; COG2186
526226007507	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226007508	DNA-binding site [nucleotide binding]; DNA binding site
526226007509	FCD domain; Region: FCD; pfam07729
526226007510	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
526226007511	L-lactate permease; Region: Lactate_perm; cl00701
526226007512	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526226007513	Cysteine-rich domain; Region: CCG; pfam02754
526226007514	Cysteine-rich domain; Region: CCG; pfam02754
526226007515	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
526226007516	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
526226007517	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
526226007518	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
526226007519	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526226007520	Beta-lactamase; Region: Beta-lactamase; pfam00144
526226007521	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526226007522	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
526226007523	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
526226007524	thymidine kinase; Provisional; Region: PRK04296
526226007525	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
526226007526	Cupin superfamily protein; Region: Cupin_4; pfam08007
526226007527	Cupin-like domain; Region: Cupin_8; pfam13621
526226007528	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
526226007529	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
526226007530	NAD(P) binding site [chemical binding]; other site
526226007531	catalytic residues [active]
526226007532	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
526226007533	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226007534	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
526226007535	active site turn [active]
526226007536	phosphorylation site [posttranslational modification]
526226007537	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
526226007538	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
526226007539	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
526226007540	HPr interaction site; other site
526226007541	glycerol kinase (GK) interaction site [polypeptide binding]; other site
526226007542	active site
526226007543	phosphorylation site [posttranslational modification]
526226007544	hypothetical protein; Provisional; Region: PRK04233
526226007545	Dodecin; Region: Dodecin; pfam07311
526226007546	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526226007547	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526226007548	Homeodomain-like domain; Region: HTH_23; pfam13384
526226007549	Winged helix-turn helix; Region: HTH_29; pfam13551
526226007550	Homeodomain-like domain; Region: HTH_32; pfam13565
526226007551	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226007552	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226007553	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526226007554	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226007555	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226007556	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226007557	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226007558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226007559	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226007560	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226007561	active site
526226007562	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
526226007563	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226007564	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226007565	AMP binding site [chemical binding]; other site
526226007566	active site
526226007567	acyl-activating enzyme (AAE) consensus motif; other site
526226007568	CoA binding site [chemical binding]; other site
526226007569	2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206
526226007570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226007571	NAD(P) binding site [chemical binding]; other site
526226007572	active site
526226007573	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226007574	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
526226007575	substrate binding site [chemical binding]; other site
526226007576	oxyanion hole (OAH) forming residues; other site
526226007577	trimer interface [polypeptide binding]; other site
526226007578	ethanolamine permease; Region: 2A0305; TIGR00908
526226007579	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
526226007580	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
526226007581	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
526226007582	Short C-terminal domain; Region: SHOCT; pfam09851
526226007583	Protein of unknown function (DUF998); Region: DUF998; pfam06197
526226007584	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
526226007585	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
526226007586	acyl-activating enzyme (AAE) consensus motif; other site
526226007587	putative AMP binding site [chemical binding]; other site
526226007588	putative active site [active]
526226007589	putative CoA binding site [chemical binding]; other site
526226007590	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
526226007591	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
526226007592	active site
526226007593	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
526226007594	catalytic triad [active]
526226007595	dimer interface [polypeptide binding]; other site
526226007596	pyruvate kinase; Provisional; Region: PRK06247
526226007597	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
526226007598	domain interfaces; other site
526226007599	active site
526226007600	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
526226007601	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226007602	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
526226007603	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
526226007604	active site
526226007605	dimer interface [polypeptide binding]; other site
526226007606	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
526226007607	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
526226007608	active site
526226007609	FMN binding site [chemical binding]; other site
526226007610	substrate binding site [chemical binding]; other site
526226007611	3Fe-4S cluster binding site [ion binding]; other site
526226007612	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
526226007613	domain interface; other site
526226007614	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
526226007615	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
526226007616	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
526226007617	substrate binding site [chemical binding]; other site
526226007618	active site
526226007619	catalytic residues [active]
526226007620	heterodimer interface [polypeptide binding]; other site
526226007621	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
526226007622	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
526226007623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226007624	catalytic residue [active]
526226007625	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
526226007626	active site
526226007627	ribulose/triose binding site [chemical binding]; other site
526226007628	phosphate binding site [ion binding]; other site
526226007629	substrate (anthranilate) binding pocket [chemical binding]; other site
526226007630	product (indole) binding pocket [chemical binding]; other site
526226007631	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
526226007632	anthranilate synthase component I; Provisional; Region: PRK13571
526226007633	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
526226007634	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
526226007635	Tautomerase enzyme; Region: Tautomerase; pfam01361
526226007636	active site 1 [active]
526226007637	dimer interface [polypeptide binding]; other site
526226007638	hexamer interface [polypeptide binding]; other site
526226007639	active site 2 [active]
526226007640	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
526226007641	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
526226007642	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
526226007643	substrate binding site [chemical binding]; other site
526226007644	glutamase interaction surface [polypeptide binding]; other site
526226007645	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
526226007646	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
526226007647	active site
526226007648	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
526226007649	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
526226007650	catalytic residues [active]
526226007651	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
526226007652	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
526226007653	putative active site [active]
526226007654	oxyanion strand; other site
526226007655	catalytic triad [active]
526226007656	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
526226007657	putative active site pocket [active]
526226007658	4-fold oligomerization interface [polypeptide binding]; other site
526226007659	metal binding residues [ion binding]; metal-binding site
526226007660	3-fold/trimer interface [polypeptide binding]; other site
526226007661	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
526226007662	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226007663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226007664	homodimer interface [polypeptide binding]; other site
526226007665	catalytic residue [active]
526226007666	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
526226007667	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
526226007668	NAD binding site [chemical binding]; other site
526226007669	dimerization interface [polypeptide binding]; other site
526226007670	product binding site; other site
526226007671	substrate binding site [chemical binding]; other site
526226007672	zinc binding site [ion binding]; other site
526226007673	catalytic residues [active]
526226007674	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
526226007675	putative active site [active]
526226007676	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
526226007677	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
526226007678	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
526226007679	dimerization interface [polypeptide binding]; other site
526226007680	active site
526226007681	quinolinate synthetase; Provisional; Region: PRK09375
526226007682	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
526226007683	active site
526226007684	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
526226007685	nudix motif; other site
526226007686	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226007687	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526226007688	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
526226007689	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
526226007690	biotin synthase; Validated; Region: PRK06256
526226007691	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226007692	FeS/SAM binding site; other site
526226007693	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
526226007694	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
526226007695	AAA domain; Region: AAA_26; pfam13500
526226007696	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
526226007697	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
526226007698	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226007699	catalytic residue [active]
526226007700	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
526226007701	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526226007702	inhibitor-cofactor binding pocket; inhibition site
526226007703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226007704	catalytic residue [active]
526226007705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226007706	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
526226007707	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
526226007708	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
526226007709	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
526226007710	active site
526226007711	catalytic site [active]
526226007712	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
526226007713	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
526226007714	active site
526226007715	catalytic site [active]
526226007716	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226007717	mce related protein; Region: MCE; pfam02470
526226007718	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226007719	mce related protein; Region: MCE; pfam02470
526226007720	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226007721	mce related protein; Region: MCE; pfam02470
526226007722	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226007723	mce related protein; Region: MCE; pfam02470
526226007724	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226007725	mce related protein; Region: MCE; pfam02470
526226007726	mce related protein; Region: MCE; pfam02470
526226007727	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
526226007728	Permease; Region: Permease; pfam02405
526226007729	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
526226007730	Permease; Region: Permease; pfam02405
526226007731	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
526226007732	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
526226007733	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
526226007734	catalytic site [active]
526226007735	active site
526226007736	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
526226007737	threonine dehydratase; Validated; Region: PRK08639
526226007738	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
526226007739	tetramer interface [polypeptide binding]; other site
526226007740	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226007741	catalytic residue [active]
526226007742	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
526226007743	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
526226007744	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
526226007745	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
526226007746	active site
526226007747	PHP Thumb interface [polypeptide binding]; other site
526226007748	metal binding site [ion binding]; metal-binding site
526226007749	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
526226007750	generic binding surface II; other site
526226007751	generic binding surface I; other site
526226007752	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226007753	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226007754	active site
526226007755	ATP binding site [chemical binding]; other site
526226007756	substrate binding site [chemical binding]; other site
526226007757	activation loop (A-loop); other site
526226007758	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
526226007759	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
526226007760	active site
526226007761	lipoprotein signal peptidase; Provisional; Region: PRK14764
526226007762	lipoprotein signal peptidase; Provisional; Region: PRK14787
526226007763	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
526226007764	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
526226007765	active site
526226007766	homotetramer interface [polypeptide binding]; other site
526226007767	homodimer interface [polypeptide binding]; other site
526226007768	DNA polymerase IV; Provisional; Region: PRK03348
526226007769	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
526226007770	active site
526226007771	DNA binding site [nucleotide binding]
526226007772	Domain of unknown function (DUF385); Region: DUF385; cl04387
526226007773	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226007774	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226007775	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
526226007776	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226007777	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
526226007778	DNA binding residues [nucleotide binding]
526226007779	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
526226007780	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
526226007781	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
526226007782	HIGH motif; other site
526226007783	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
526226007784	active site
526226007785	KMSKS motif; other site
526226007786	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
526226007787	tRNA binding surface [nucleotide binding]; other site
526226007788	anticodon binding site; other site
526226007789	DivIVA domain; Region: DivI1A_domain; TIGR03544
526226007790	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
526226007791	Protein of unknown function (DUF552); Region: DUF552; cl00775
526226007792	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
526226007793	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
526226007794	catalytic residue [active]
526226007795	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
526226007796	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
526226007797	cell division protein FtsZ; Validated; Region: PRK09330
526226007798	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
526226007799	nucleotide binding site [chemical binding]; other site
526226007800	SulA interaction site; other site
526226007801	cell division protein FtsQ; Provisional; Region: PRK05529
526226007802	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
526226007803	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
526226007804	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
526226007805	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526226007806	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526226007807	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
526226007808	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
526226007809	active site
526226007810	homodimer interface [polypeptide binding]; other site
526226007811	cell division protein FtsW; Region: ftsW; TIGR02614
526226007812	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
526226007813	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526226007814	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526226007815	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
526226007816	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
526226007817	Mg++ binding site [ion binding]; other site
526226007818	putative catalytic motif [active]
526226007819	putative substrate binding site [chemical binding]; other site
526226007820	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
526226007821	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
526226007822	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
526226007823	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
526226007824	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
526226007825	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
526226007826	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
526226007827	MraW methylase family; Region: Methyltransf_5; cl17771
526226007828	cell division protein MraZ; Reviewed; Region: PRK00326
526226007829	MraZ protein; Region: MraZ; pfam02381
526226007830	MraZ protein; Region: MraZ; pfam02381
526226007831	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
526226007832	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
526226007833	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
526226007834	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226007835	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
526226007836	FAD binding site [chemical binding]; other site
526226007837	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
526226007838	substrate binding pocket [chemical binding]; other site
526226007839	chain length determination region; other site
526226007840	substrate-Mg2+ binding site; other site
526226007841	catalytic residues [active]
526226007842	aspartate-rich region 1; other site
526226007843	active site lid residues [active]
526226007844	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
526226007845	aspartate-rich region 2; other site
526226007846	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
526226007847	Helix-turn-helix domain; Region: HTH_17; pfam12728
526226007848	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226007849	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226007850	active site
526226007851	ATP binding site [chemical binding]; other site
526226007852	substrate binding site [chemical binding]; other site
526226007853	activation loop (A-loop); other site
526226007854	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
526226007855	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
526226007856	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
526226007857	active site
526226007858	8-oxo-dGMP binding site [chemical binding]; other site
526226007859	nudix motif; other site
526226007860	metal binding site [ion binding]; metal-binding site
526226007861	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526226007862	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526226007863	putative acyl-acceptor binding pocket; other site
526226007864	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526226007865	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
526226007866	nucleotide binding site [chemical binding]; other site
526226007867	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
526226007868	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526226007869	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
526226007870	putative hydrophobic ligand binding site [chemical binding]; other site
526226007871	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
526226007872	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
526226007873	acyl-activating enzyme (AAE) consensus motif; other site
526226007874	putative AMP binding site [chemical binding]; other site
526226007875	putative active site [active]
526226007876	putative CoA binding site [chemical binding]; other site
526226007877	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226007878	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226007879	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
526226007880	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526226007881	NlpC/P60 family; Region: NLPC_P60; pfam00877
526226007882	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
526226007883	NlpC/P60 family; Region: NLPC_P60; pfam00877
526226007884	hypothetical protein; Validated; Region: PRK07883
526226007885	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
526226007886	active site
526226007887	substrate binding site [chemical binding]; other site
526226007888	catalytic site [active]
526226007889	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
526226007890	GIY-YIG motif/motif A; other site
526226007891	active site
526226007892	catalytic site [active]
526226007893	putative DNA binding site [nucleotide binding]; other site
526226007894	metal binding site [ion binding]; metal-binding site
526226007895	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
526226007896	AsnC family; Region: AsnC_trans_reg; pfam01037
526226007897	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
526226007898	anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245
526226007899	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
526226007900	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
526226007901	Subunit I/III interface [polypeptide binding]; other site
526226007902	Cytochrome c; Region: Cytochrom_C; pfam00034
526226007903	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
526226007904	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
526226007905	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
526226007906	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
526226007907	iron-sulfur cluster [ion binding]; other site
526226007908	[2Fe-2S] cluster binding site [ion binding]; other site
526226007909	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
526226007910	heme bH binding site [chemical binding]; other site
526226007911	intrachain domain interface; other site
526226007912	heme bL binding site [chemical binding]; other site
526226007913	interchain domain interface [polypeptide binding]; other site
526226007914	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
526226007915	Qo binding site; other site
526226007916	putative lipid kinase; Reviewed; Region: PRK13057
526226007917	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
526226007918	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
526226007919	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
526226007920	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
526226007921	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
526226007922	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
526226007923	dimer interface [polypeptide binding]; other site
526226007924	active site
526226007925	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
526226007926	Ligand Binding Site [chemical binding]; other site
526226007927	Molecular Tunnel; other site
526226007928	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
526226007929	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526226007930	substrate binding site [chemical binding]; other site
526226007931	ATP binding site [chemical binding]; other site
526226007932	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
526226007933	Glycerate kinase family; Region: Gly_kinase; cl00841
526226007934	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
526226007935	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
526226007936	homotrimer interface [polypeptide binding]; other site
526226007937	Walker A motif; other site
526226007938	GTP binding site [chemical binding]; other site
526226007939	Walker B motif; other site
526226007940	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
526226007941	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
526226007942	putative dimer interface [polypeptide binding]; other site
526226007943	active site pocket [active]
526226007944	putative cataytic base [active]
526226007945	cobalamin synthase; Reviewed; Region: cobS; PRK00235
526226007946	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
526226007947	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
526226007948	homodimer interface [polypeptide binding]; other site
526226007949	substrate-cofactor binding pocket; other site
526226007950	catalytic residue [active]
526226007951	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
526226007952	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
526226007953	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
526226007954	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776
526226007955	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
526226007956	multifunctional aminopeptidase A; Provisional; Region: PRK00913
526226007957	interface (dimer of trimers) [polypeptide binding]; other site
526226007958	Substrate-binding/catalytic site; other site
526226007959	Zn-binding sites [ion binding]; other site
526226007960	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526226007961	E3 interaction surface; other site
526226007962	lipoyl attachment site [posttranslational modification]; other site
526226007963	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
526226007964	E3 interaction surface; other site
526226007965	lipoyl attachment site [posttranslational modification]; other site
526226007966	e3 binding domain; Region: E3_binding; pfam02817
526226007967	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
526226007968	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
526226007969	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
526226007970	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
526226007971	putative NAD(P) binding site [chemical binding]; other site
526226007972	putative active site [active]
526226007973	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
526226007974	lipoyl synthase; Provisional; Region: PRK05481
526226007975	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226007976	FeS/SAM binding site; other site
526226007977	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
526226007978	RDD family; Region: RDD; pfam06271
526226007979	glutamine synthetase, type I; Region: GlnA; TIGR00653
526226007980	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
526226007981	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
526226007982	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
526226007983	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226007984	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226007985	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
526226007986	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
526226007987	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
526226007988	heme binding pocket [chemical binding]; other site
526226007989	heme ligand [chemical binding]; other site
526226007990	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526226007991	putative catalytic site [active]
526226007992	putative metal binding site [ion binding]; other site
526226007993	putative phosphate binding site [ion binding]; other site
526226007994	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526226007995	putative catalytic site [active]
526226007996	putative metal binding site [ion binding]; other site
526226007997	putative phosphate binding site [ion binding]; other site
526226007998	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
526226007999	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
526226008000	metal binding triad; other site
526226008001	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
526226008002	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
526226008003	metal binding triad; other site
526226008004	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
526226008005	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
526226008006	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
526226008007	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
526226008008	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
526226008009	oligomerization interface [polypeptide binding]; other site
526226008010	active site
526226008011	metal binding site [ion binding]; metal-binding site
526226008012	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
526226008013	TAP-like protein; Region: Abhydrolase_4; pfam08386
526226008014	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
526226008015	putative active site; other site
526226008016	putative metal binding residues [ion binding]; other site
526226008017	signature motif; other site
526226008018	putative triphosphate binding site [ion binding]; other site
526226008019	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
526226008020	RNB domain; Region: RNB; pfam00773
526226008021	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
526226008022	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
526226008023	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226008024	catalytic core [active]
526226008025	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
526226008026	Putative zinc ribbon domain; Region: DUF164; pfam02591
526226008027	Uncharacterized conserved protein [Function unknown]; Region: COG0327
526226008028	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
526226008029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
526226008030	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
526226008031	hypothetical protein; Provisional; Region: PRK07908
526226008032	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226008033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226008034	homodimer interface [polypeptide binding]; other site
526226008035	catalytic residue [active]
526226008036	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
526226008037	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226008038	motif II; other site
526226008039	Low molecular weight phosphatase family; Region: LMWPc; cd00115
526226008040	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
526226008041	active site
526226008042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
526226008043	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
526226008044	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
526226008045	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
526226008046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226008047	S-adenosylmethionine binding site [chemical binding]; other site
526226008048	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226008049	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226008050	active site
526226008051	ATP binding site [chemical binding]; other site
526226008052	substrate binding site [chemical binding]; other site
526226008053	activation loop (A-loop); other site
526226008054	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526226008055	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526226008056	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226008057	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226008058	active site
526226008059	ATP binding site [chemical binding]; other site
526226008060	substrate binding site [chemical binding]; other site
526226008061	activation loop (A-loop); other site
526226008062	Predicted transcriptional regulator [Transcription]; Region: COG2378
526226008063	HTH domain; Region: HTH_11; pfam08279
526226008064	WYL domain; Region: WYL; pfam13280
526226008065	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526226008066	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
526226008067	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226008068	Walker A/P-loop; other site
526226008069	ATP binding site [chemical binding]; other site
526226008070	Q-loop/lid; other site
526226008071	ABC transporter signature motif; other site
526226008072	Walker B; other site
526226008073	D-loop; other site
526226008074	H-loop/switch region; other site
526226008075	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226008076	active site
526226008077	ATP binding site [chemical binding]; other site
526226008078	Protein kinase domain; Region: Pkinase; pfam00069
526226008079	substrate binding site [chemical binding]; other site
526226008080	activation loop (A-loop); other site
526226008081	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
526226008082	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
526226008083	conserved cys residue [active]
526226008084	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226008085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226008086	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
526226008087	active site
526226008088	catalytic triad [active]
526226008089	oxyanion hole [active]
526226008090	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
526226008091	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
526226008092	catalytic triad [active]
526226008093	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
526226008094	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
526226008095	dimer interface [polypeptide binding]; other site
526226008096	catalytic triad [active]
526226008097	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
526226008098	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
526226008099	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
526226008100	dimer interface [polypeptide binding]; other site
526226008101	TPP-binding site [chemical binding]; other site
526226008102	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
526226008103	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526226008104	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
526226008105	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
526226008106	acyl carrier protein; Provisional; Region: acpP; PRK00982
526226008107	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
526226008108	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
526226008109	dimer interface [polypeptide binding]; other site
526226008110	active site
526226008111	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
526226008112	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
526226008113	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526226008114	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
526226008115	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526226008116	Beta-lactamase; Region: Beta-lactamase; pfam00144
526226008117	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
526226008118	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
526226008119	NAD binding site [chemical binding]; other site
526226008120	catalytic Zn binding site [ion binding]; other site
526226008121	substrate binding site [chemical binding]; other site
526226008122	structural Zn binding site [ion binding]; other site
526226008123	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
526226008124	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226008125	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
526226008126	acyl-activating enzyme (AAE) consensus motif; other site
526226008127	putative AMP binding site [chemical binding]; other site
526226008128	putative active site [active]
526226008129	acyl-activating enzyme (AAE) consensus motif; other site
526226008130	putative CoA binding site [chemical binding]; other site
526226008131	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
526226008132	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226008133	substrate binding site [chemical binding]; other site
526226008134	oxyanion hole (OAH) forming residues; other site
526226008135	trimer interface [polypeptide binding]; other site
526226008136	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226008137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226008138	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226008139	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226008140	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226008141	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226008142	active site
526226008143	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526226008144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226008145	DNA-binding site [nucleotide binding]; DNA binding site
526226008146	FCD domain; Region: FCD; pfam07729
526226008147	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
526226008148	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226008149	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226008150	dimerization interface [polypeptide binding]; other site
526226008151	putative DNA binding site [nucleotide binding]; other site
526226008152	putative Zn2+ binding site [ion binding]; other site
526226008153	H+ Antiporter protein; Region: 2A0121; TIGR00900
526226008154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226008155	putative substrate translocation pore; other site
526226008156	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
526226008157	DNA primase; Validated; Region: dnaG; PRK05667
526226008158	CHC2 zinc finger; Region: zf-CHC2; cl17510
526226008159	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
526226008160	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
526226008161	active site
526226008162	metal binding site [ion binding]; metal-binding site
526226008163	interdomain interaction site; other site
526226008164	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
526226008165	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
526226008166	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
526226008167	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526226008168	Zn2+ binding site [ion binding]; other site
526226008169	Mg2+ binding site [ion binding]; other site
526226008170	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
526226008171	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
526226008172	DNA-binding site [nucleotide binding]; DNA binding site
526226008173	RNA-binding motif; other site
526226008174	glycyl-tRNA synthetase; Provisional; Region: PRK04173
526226008175	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526226008176	motif 1; other site
526226008177	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
526226008178	active site
526226008179	motif 2; other site
526226008180	motif 3; other site
526226008181	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
526226008182	anticodon binding site; other site
526226008183	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
526226008184	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
526226008185	PA/protease or protease-like domain interface [polypeptide binding]; other site
526226008186	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
526226008187	Peptidase family M28; Region: Peptidase_M28; pfam04389
526226008188	active site
526226008189	metal binding site [ion binding]; metal-binding site
526226008190	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226008191	dimerization interface [polypeptide binding]; other site
526226008192	putative DNA binding site [nucleotide binding]; other site
526226008193	putative Zn2+ binding site [ion binding]; other site
526226008194	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
526226008195	putative DNA binding helix; other site
526226008196	metal binding site 2 [ion binding]; metal-binding site
526226008197	metal binding site 1 [ion binding]; metal-binding site
526226008198	dimer interface [polypeptide binding]; other site
526226008199	structural Zn2+ binding site [ion binding]; other site
526226008200	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
526226008201	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
526226008202	catalytic residue [active]
526226008203	putative FPP diphosphate  binding site; other site
526226008204	putative FPP binding hydrophobic cleft; other site
526226008205	dimer interface [polypeptide binding]; other site
526226008206	putative IPP diphosphate binding site; other site
526226008207	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
526226008208	Recombination protein O N terminal; Region: RecO_N; pfam11967
526226008209	Recombination protein O C terminal; Region: RecO_C; pfam02565
526226008210	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
526226008211	Protein of unknown function (DUF3533); Region: DUF3533; pfam12051
526226008212	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
526226008213	GTPase Era; Reviewed; Region: era; PRK00089
526226008214	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
526226008215	G1 box; other site
526226008216	GTP/Mg2+ binding site [chemical binding]; other site
526226008217	Switch I region; other site
526226008218	G2 box; other site
526226008219	Switch II region; other site
526226008220	G3 box; other site
526226008221	G4 box; other site
526226008222	G5 box; other site
526226008223	KH domain; Region: KH_2; pfam07650
526226008224	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
526226008225	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
526226008226	Domain of unknown function DUF21; Region: DUF21; pfam01595
526226008227	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
526226008228	metal-binding heat shock protein; Provisional; Region: PRK00016
526226008229	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
526226008230	PhoH-like protein; Region: PhoH; pfam02562
526226008231	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526226008232	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
526226008233	chaperone protein DnaJ; Provisional; Region: PRK14278
526226008234	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
526226008235	HSP70 interaction site [polypeptide binding]; other site
526226008236	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
526226008237	Zn binding sites [ion binding]; other site
526226008238	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
526226008239	dimer interface [polypeptide binding]; other site
526226008240	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
526226008241	HTH domain; Region: HTH_11; cl17392
526226008242	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
526226008243	coproporphyrinogen III oxidase; Validated; Region: PRK05628
526226008244	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226008245	FeS/SAM binding site; other site
526226008246	HemN C-terminal domain; Region: HemN_C; pfam06969
526226008247	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
526226008248	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526226008249	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526226008250	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
526226008251	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
526226008252	Active Sites [active]
526226008253	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
526226008254	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
526226008255	Active Sites [active]
526226008256	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
526226008257	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
526226008258	CysD dimerization site [polypeptide binding]; other site
526226008259	G1 box; other site
526226008260	putative GEF interaction site [polypeptide binding]; other site
526226008261	GTP/Mg2+ binding site [chemical binding]; other site
526226008262	Switch I region; other site
526226008263	G2 box; other site
526226008264	G3 box; other site
526226008265	Switch II region; other site
526226008266	G4 box; other site
526226008267	G5 box; other site
526226008268	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
526226008269	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
526226008270	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
526226008271	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
526226008272	putative active site [active]
526226008273	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
526226008274	putative active site [active]
526226008275	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226008276	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
526226008277	Walker A/P-loop; other site
526226008278	ATP binding site [chemical binding]; other site
526226008279	Q-loop/lid; other site
526226008280	ABC transporter signature motif; other site
526226008281	Walker B; other site
526226008282	D-loop; other site
526226008283	H-loop/switch region; other site
526226008284	TOBE domain; Region: TOBE; pfam03459
526226008285	sulfate transport protein; Provisional; Region: cysT; CHL00187
526226008286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226008287	dimer interface [polypeptide binding]; other site
526226008288	conserved gate region; other site
526226008289	putative PBP binding loops; other site
526226008290	ABC-ATPase subunit interface; other site
526226008291	sulfate transport protein; Provisional; Region: cysT; CHL00187
526226008292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226008293	dimer interface [polypeptide binding]; other site
526226008294	conserved gate region; other site
526226008295	putative PBP binding loops; other site
526226008296	ABC-ATPase subunit interface; other site
526226008297	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
526226008298	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
526226008299	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
526226008300	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
526226008301	active site
526226008302	Zn binding site [ion binding]; other site
526226008303	GTP-binding protein LepA; Provisional; Region: PRK05433
526226008304	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
526226008305	G1 box; other site
526226008306	putative GEF interaction site [polypeptide binding]; other site
526226008307	GTP/Mg2+ binding site [chemical binding]; other site
526226008308	Switch I region; other site
526226008309	G2 box; other site
526226008310	G3 box; other site
526226008311	Switch II region; other site
526226008312	G4 box; other site
526226008313	G5 box; other site
526226008314	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
526226008315	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
526226008316	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
526226008317	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
526226008318	PemK-like protein; Region: PemK; pfam02452
526226008319	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
526226008320	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
526226008321	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
526226008322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
526226008323	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
526226008324	Uncharacterized conserved protein [Function unknown]; Region: COG2308
526226008325	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
526226008326	hypothetical protein; Reviewed; Region: PRK07914
526226008327	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
526226008328	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
526226008329	Competence protein; Region: Competence; pfam03772
526226008330	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
526226008331	Helix-hairpin-helix motif; Region: HHH; pfam00633
526226008332	EDD domain protein, DegV family; Region: DegV; TIGR00762
526226008333	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
526226008334	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
526226008335	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226008336	catalytic core [active]
526226008337	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
526226008338	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
526226008339	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
526226008340	active site
526226008341	(T/H)XGH motif; other site
526226008342	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
526226008343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226008344	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
526226008345	Walker A motif; other site
526226008346	ATP binding site [chemical binding]; other site
526226008347	Walker B motif; other site
526226008348	arginine finger; other site
526226008349	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
526226008350	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
526226008351	putative catalytic cysteine [active]
526226008352	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
526226008353	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
526226008354	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
526226008355	generic binding surface II; other site
526226008356	ssDNA binding site; other site
526226008357	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226008358	ATP binding site [chemical binding]; other site
526226008359	putative Mg++ binding site [ion binding]; other site
526226008360	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226008361	ATP-binding site [chemical binding]; other site
526226008362	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
526226008363	DAK2 domain; Region: Dak2; pfam02734
526226008364	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
526226008365	enoyl-CoA hydratase; Provisional; Region: PRK06688
526226008366	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226008367	substrate binding site [chemical binding]; other site
526226008368	oxyanion hole (OAH) forming residues; other site
526226008369	trimer interface [polypeptide binding]; other site
526226008370	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
526226008371	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
526226008372	ligand binding site [chemical binding]; other site
526226008373	active site
526226008374	UGI interface [polypeptide binding]; other site
526226008375	catalytic site [active]
526226008376	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
526226008377	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
526226008378	trimer interface [polypeptide binding]; other site
526226008379	putative metal binding site [ion binding]; other site
526226008380	thiamine monophosphate kinase; Provisional; Region: PRK05731
526226008381	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
526226008382	ATP binding site [chemical binding]; other site
526226008383	dimerization interface [polypeptide binding]; other site
526226008384	AsnC family; Region: AsnC_trans_reg; pfam01037
526226008385	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
526226008386	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
526226008387	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
526226008388	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
526226008389	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
526226008390	polyphosphate kinase; Provisional; Region: PRK05443
526226008391	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
526226008392	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
526226008393	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
526226008394	putative domain interface [polypeptide binding]; other site
526226008395	putative active site [active]
526226008396	catalytic site [active]
526226008397	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
526226008398	putative active site [active]
526226008399	catalytic site [active]
526226008400	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
526226008401	active site
526226008402	Ap6A binding site [chemical binding]; other site
526226008403	nudix motif; other site
526226008404	metal binding site [ion binding]; metal-binding site
526226008405	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226008406	catalytic core [active]
526226008407	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
526226008408	IHF - DNA interface [nucleotide binding]; other site
526226008409	IHF dimer interface [polypeptide binding]; other site
526226008410	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
526226008411	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
526226008412	substrate binding site [chemical binding]; other site
526226008413	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
526226008414	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
526226008415	substrate binding site [chemical binding]; other site
526226008416	ligand binding site [chemical binding]; other site
526226008417	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
526226008418	Transcriptional regulator [Transcription]; Region: IclR; COG1414
526226008419	Bacterial transcriptional regulator; Region: IclR; pfam01614
526226008420	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
526226008421	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
526226008422	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
526226008423	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
526226008424	HIGH motif; other site
526226008425	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
526226008426	active site
526226008427	KMSKS motif; other site
526226008428	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226008429	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526226008430	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
526226008431	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
526226008432	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
526226008433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226008434	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226008435	putative substrate translocation pore; other site
526226008436	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
526226008437	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226008438	DNA-binding site [nucleotide binding]; DNA binding site
526226008439	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
526226008440	tartrate dehydrogenase; Region: TTC; TIGR02089
526226008441	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
526226008442	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
526226008443	ligand binding site [chemical binding]; other site
526226008444	NAD binding site [chemical binding]; other site
526226008445	dimerization interface [polypeptide binding]; other site
526226008446	catalytic site [active]
526226008447	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
526226008448	putative L-serine binding site [chemical binding]; other site
526226008449	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526226008450	ketol-acid reductoisomerase; Provisional; Region: PRK05479
526226008451	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
526226008452	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
526226008453	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
526226008454	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
526226008455	putative valine binding site [chemical binding]; other site
526226008456	dimer interface [polypeptide binding]; other site
526226008457	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
526226008458	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
526226008459	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526226008460	PYR/PP interface [polypeptide binding]; other site
526226008461	dimer interface [polypeptide binding]; other site
526226008462	TPP binding site [chemical binding]; other site
526226008463	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526226008464	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
526226008465	TPP-binding site [chemical binding]; other site
526226008466	dimer interface [polypeptide binding]; other site
526226008467	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
526226008468	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
526226008469	DoxX; Region: DoxX; pfam07681
526226008470	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
526226008471	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
526226008472	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
526226008473	GatB domain; Region: GatB_Yqey; smart00845
526226008474	PspC domain; Region: PspC; pfam04024
526226008475	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
526226008476	phosphofructokinase; Region: PFK_mixed; TIGR02483
526226008477	active site
526226008478	ADP/pyrophosphate binding site [chemical binding]; other site
526226008479	dimerization interface [polypeptide binding]; other site
526226008480	allosteric effector site; other site
526226008481	fructose-1,6-bisphosphate binding site; other site
526226008482	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226008483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226008484	active site
526226008485	phosphorylation site [posttranslational modification]
526226008486	intermolecular recognition site; other site
526226008487	dimerization interface [polypeptide binding]; other site
526226008488	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226008489	DNA binding residues [nucleotide binding]
526226008490	dimerization interface [polypeptide binding]; other site
526226008491	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526226008492	Histidine kinase; Region: HisKA_3; pfam07730
526226008493	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526226008494	ATP binding site [chemical binding]; other site
526226008495	Mg2+ binding site [ion binding]; other site
526226008496	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
526226008497	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
526226008498	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
526226008499	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
526226008500	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526226008501	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226008502	active site
526226008503	metal binding site [ion binding]; metal-binding site
526226008504	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
526226008505	SnoaL-like domain; Region: SnoaL_2; pfam12680
526226008506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226008507	NAD(P) binding site [chemical binding]; other site
526226008508	active site
526226008509	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526226008510	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226008511	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
526226008512	dimerization interface [polypeptide binding]; other site
526226008513	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
526226008514	putative ADP-ribose binding site [chemical binding]; other site
526226008515	putative active site [active]
526226008516	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
526226008517	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
526226008518	nucleotide binding pocket [chemical binding]; other site
526226008519	K-X-D-G motif; other site
526226008520	catalytic site [active]
526226008521	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
526226008522	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
526226008523	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
526226008524	Dimer interface [polypeptide binding]; other site
526226008525	BRCT sequence motif; other site
526226008526	Protein of unknown function (DUF419); Region: DUF419; pfam04237
526226008527	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
526226008528	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
526226008529	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
526226008530	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
526226008531	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
526226008532	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226008533	catalytic residue [active]
526226008534	GXWXG protein; Region: GXWXG; pfam14231
526226008535	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
526226008536	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526226008537	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526226008538	putative acyl-acceptor binding pocket; other site
526226008539	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
526226008540	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
526226008541	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
526226008542	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
526226008543	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
526226008544	Ligand binding site [chemical binding]; other site
526226008545	Electron transfer flavoprotein domain; Region: ETF; pfam01012
526226008546	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226008547	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526226008548	S-adenosylmethionine binding site [chemical binding]; other site
526226008549	Uncharacterized conserved protein [Function unknown]; Region: COG1543
526226008550	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
526226008551	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
526226008552	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226008553	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226008554	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
526226008555	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
526226008556	trimer interface [polypeptide binding]; other site
526226008557	active site
526226008558	substrate binding site [chemical binding]; other site
526226008559	CoA binding site [chemical binding]; other site
526226008560	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
526226008561	Methyltransferase domain; Region: Methyltransf_26; pfam13659
526226008562	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
526226008563	Methyltransferase domain; Region: Methyltransf_31; pfam13847
526226008564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226008565	S-adenosylmethionine binding site [chemical binding]; other site
526226008566	enoyl-CoA hydratase; Provisional; Region: PRK05862
526226008567	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226008568	substrate binding site [chemical binding]; other site
526226008569	oxyanion hole (OAH) forming residues; other site
526226008570	trimer interface [polypeptide binding]; other site
526226008571	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
526226008572	nucleotide binding site [chemical binding]; other site
526226008573	tetracycline repressor protein TetR; Provisional; Region: PRK13756
526226008574	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
526226008575	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
526226008576	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188
526226008577	NAD(P) binding site [chemical binding]; other site
526226008578	NUDIX domain; Region: NUDIX; pfam00293
526226008579	nudix motif; other site
526226008580	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
526226008581	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226008582	Walker A/P-loop; other site
526226008583	ATP binding site [chemical binding]; other site
526226008584	Q-loop/lid; other site
526226008585	ABC transporter signature motif; other site
526226008586	Walker B; other site
526226008587	D-loop; other site
526226008588	H-loop/switch region; other site
526226008589	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
526226008590	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226008591	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
526226008592	Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869
526226008593	dimer interface [polypeptide binding]; other site
526226008594	putative active site [active]
526226008595	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
526226008596	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
526226008597	phosphoserine phosphatase SerB; Region: serB; TIGR00338
526226008598	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
526226008599	motif II; other site
526226008600	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
526226008601	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
526226008602	D-pathway; other site
526226008603	Putative ubiquinol binding site [chemical binding]; other site
526226008604	Low-spin heme (heme b) binding site [chemical binding]; other site
526226008605	Putative water exit pathway; other site
526226008606	Binuclear center (heme o3/CuB) [ion binding]; other site
526226008607	K-pathway; other site
526226008608	Putative proton exit pathway; other site
526226008609	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
526226008610	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526226008611	intersubunit interface [polypeptide binding]; other site
526226008612	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
526226008613	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
526226008614	tetramer interface [polypeptide binding]; other site
526226008615	active site
526226008616	Mg2+/Mn2+ binding site [ion binding]; other site
526226008617	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
526226008618	active site clefts [active]
526226008619	zinc binding site [ion binding]; other site
526226008620	dimer interface [polypeptide binding]; other site
526226008621	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
526226008622	SNF2 Helicase protein; Region: DUF3670; pfam12419
526226008623	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
526226008624	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
526226008625	ATP binding site [chemical binding]; other site
526226008626	putative Mg++ binding site [ion binding]; other site
526226008627	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226008628	nucleotide binding region [chemical binding]; other site
526226008629	ATP-binding site [chemical binding]; other site
526226008630	Uncharacterized conserved protein [Function unknown]; Region: COG4279
526226008631	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
526226008632	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
526226008633	dimer interface [polypeptide binding]; other site
526226008634	putative radical transfer pathway; other site
526226008635	diiron center [ion binding]; other site
526226008636	tyrosyl radical; other site
526226008637	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
526226008638	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
526226008639	Class I ribonucleotide reductase; Region: RNR_I; cd01679
526226008640	active site
526226008641	dimer interface [polypeptide binding]; other site
526226008642	catalytic residues [active]
526226008643	effector binding site; other site
526226008644	R2 peptide binding site; other site
526226008645	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
526226008646	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
526226008647	catalytic residues [active]
526226008648	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526226008649	Predicted flavoprotein [General function prediction only]; Region: COG0431
526226008650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226008651	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226008652	salicylate hydroxylase; Provisional; Region: PRK08163
526226008653	hypothetical protein; Provisional; Region: PRK07236
526226008654	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
526226008655	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
526226008656	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
526226008657	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
526226008658	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
526226008659	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
526226008660	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
526226008661	Transcription factor WhiB; Region: Whib; pfam02467
526226008662	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
526226008663	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
526226008664	phosphate binding site [ion binding]; other site
526226008665	dimer interface [polypeptide binding]; other site
526226008666	substrate binding site [chemical binding]; other site
526226008667	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
526226008668	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
526226008669	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
526226008670	putative FMN binding site [chemical binding]; other site
526226008671	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
526226008672	nudix motif; other site
526226008673	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
526226008674	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
526226008675	ligand binding site; other site
526226008676	oligomer interface; other site
526226008677	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
526226008678	dimer interface [polypeptide binding]; other site
526226008679	N-terminal domain interface [polypeptide binding]; other site
526226008680	sulfate 1 binding site; other site
526226008681	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
526226008682	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226008683	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
526226008684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226008685	S-adenosylmethionine binding site [chemical binding]; other site
526226008686	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
526226008687	DivIVA domain; Region: DivI1A_domain; TIGR03544
526226008688	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
526226008689	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526226008690	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
526226008691	dihydropteroate synthase; Region: DHPS; TIGR01496
526226008692	substrate binding pocket [chemical binding]; other site
526226008693	dimer interface [polypeptide binding]; other site
526226008694	inhibitor binding site; inhibition site
526226008695	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
526226008696	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
526226008697	acyl-activating enzyme (AAE) consensus motif; other site
526226008698	putative AMP binding site [chemical binding]; other site
526226008699	putative active site [active]
526226008700	putative CoA binding site [chemical binding]; other site
526226008701	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
526226008702	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
526226008703	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
526226008704	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
526226008705	metal binding site [ion binding]; metal-binding site
526226008706	putative dimer interface [polypeptide binding]; other site
526226008707	Electron transfer DM13; Region: DM13; pfam10517
526226008708	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226008709	Mitomycin C resistance protein (MRD); Region: MRD; cd07235
526226008710	dimer interface [polypeptide binding]; other site
526226008711	ligand binding site [chemical binding]; other site
526226008712	Helix-turn-helix domain; Region: HTH_18; pfam12833
526226008713	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226008714	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
526226008715	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
526226008716	putative trimer interface [polypeptide binding]; other site
526226008717	putative CoA binding site [chemical binding]; other site
526226008718	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
526226008719	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226008720	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226008721	homodimer interface [polypeptide binding]; other site
526226008722	catalytic residue [active]
526226008723	Ferredoxin [Energy production and conversion]; Region: COG1146
526226008724	4Fe-4S binding domain; Region: Fer4; pfam00037
526226008725	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
526226008726	Rhodanese Homology Domain; Region: RHOD; smart00450
526226008727	active site residue [active]
526226008728	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Region: F420_cofG; TIGR03550
526226008729	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226008730	FeS/SAM binding site; other site
526226008731	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226008732	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226008733	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551
526226008734	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
526226008735	putative active site [active]
526226008736	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
526226008737	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
526226008738	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526226008739	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
526226008740	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
526226008741	G1 box; other site
526226008742	putative GEF interaction site [polypeptide binding]; other site
526226008743	GTP/Mg2+ binding site [chemical binding]; other site
526226008744	Switch I region; other site
526226008745	G2 box; other site
526226008746	G3 box; other site
526226008747	Switch II region; other site
526226008748	G4 box; other site
526226008749	G5 box; other site
526226008750	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
526226008751	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
526226008752	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
526226008753	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226008754	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
526226008755	Walker A/P-loop; other site
526226008756	ATP binding site [chemical binding]; other site
526226008757	Q-loop/lid; other site
526226008758	ABC transporter signature motif; other site
526226008759	Walker B; other site
526226008760	D-loop; other site
526226008761	H-loop/switch region; other site
526226008762	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
526226008763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
526226008764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226008765	dimer interface [polypeptide binding]; other site
526226008766	conserved gate region; other site
526226008767	putative PBP binding loops; other site
526226008768	ABC-ATPase subunit interface; other site
526226008769	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
526226008770	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
526226008771	YhhN-like protein; Region: YhhN; pfam07947
526226008772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226008773	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
526226008774	putative substrate translocation pore; other site
526226008775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226008776	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
526226008777	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
526226008778	CsbD-like; Region: CsbD; pfam05532
526226008779	Asp23 family; Region: Asp23; pfam03780
526226008780	Asp23 family; Region: Asp23; pfam03780
526226008781	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
526226008782	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226008783	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226008784	DNA binding residues [nucleotide binding]
526226008785	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
526226008786	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
526226008787	Flavin binding site [chemical binding]; other site
526226008788	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
526226008789	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
526226008790	active site
526226008791	enoyl-CoA hydratase; Provisional; Region: PRK06494
526226008792	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226008793	substrate binding site [chemical binding]; other site
526226008794	oxyanion hole (OAH) forming residues; other site
526226008795	trimer interface [polypeptide binding]; other site
526226008796	TIGR03086 family protein; Region: TIGR03086
526226008797	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
526226008798	Domain of unknown function DUF20; Region: UPF0118; pfam01594
526226008799	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
526226008800	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
526226008801	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226008802	active site
526226008803	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
526226008804	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226008805	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
526226008806	active site
526226008807	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226008808	enoyl-CoA hydratase; Validated; Region: PRK08139
526226008809	substrate binding site [chemical binding]; other site
526226008810	oxyanion hole (OAH) forming residues; other site
526226008811	trimer interface [polypeptide binding]; other site
526226008812	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
526226008813	Carbon starvation protein CstA; Region: CstA; pfam02554
526226008814	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
526226008815	Protein of unknown function (DUF466); Region: DUF466; cl01082
526226008816	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226008817	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226008818	Cytochrome P450; Region: p450; cl12078
526226008819	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226008820	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
526226008821	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
526226008822	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526226008823	MFS/sugar transport protein; Region: MFS_2; pfam13347
526226008824	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
526226008825	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226008826	catalytic residue [active]
526226008827	hypothetical protein; Provisional; Region: PRK07945
526226008828	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
526226008829	active site
526226008830	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
526226008831	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226008832	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226008833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226008834	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
526226008835	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
526226008836	Multicopper oxidase; Region: Cu-oxidase; pfam00394
526226008837	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
526226008838	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
526226008839	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
526226008840	PemK-like protein; Region: PemK; pfam02452
526226008841	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526226008842	putative active site [active]
526226008843	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
526226008844	GTP-binding protein YchF; Reviewed; Region: PRK09601
526226008845	YchF GTPase; Region: YchF; cd01900
526226008846	G1 box; other site
526226008847	GTP/Mg2+ binding site [chemical binding]; other site
526226008848	Switch I region; other site
526226008849	G2 box; other site
526226008850	Switch II region; other site
526226008851	G3 box; other site
526226008852	G4 box; other site
526226008853	G5 box; other site
526226008854	Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071
526226008855	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
526226008856	Domain of unknown function DUF20; Region: UPF0118; pfam01594
526226008857	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
526226008858	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
526226008859	AlkA N-terminal domain; Region: AlkA_N; pfam06029
526226008860	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
526226008861	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
526226008862	minor groove reading motif; other site
526226008863	helix-hairpin-helix signature motif; other site
526226008864	substrate binding pocket [chemical binding]; other site
526226008865	active site
526226008866	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
526226008867	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
526226008868	DNA binding site [nucleotide binding]
526226008869	active site
526226008870	RmuC family; Region: RmuC; pfam02646
526226008871	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
526226008872	nucleosidase; Provisional; Region: PRK05634
526226008873	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
526226008874	Fructosamine kinase; Region: Fructosamin_kin; cl17579
526226008875	Phosphotransferase enzyme family; Region: APH; pfam01636
526226008876	short chain dehydrogenase; Provisional; Region: PRK07832
526226008877	classical (c) SDRs; Region: SDR_c; cd05233
526226008878	NAD(P) binding site [chemical binding]; other site
526226008879	active site
526226008880	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
526226008881	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526226008882	active site
526226008883	metal binding site [ion binding]; metal-binding site
526226008884	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
526226008885	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
526226008886	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
526226008887	hypothetical protein; Validated; Region: PRK01415
526226008888	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
526226008889	active site residue [active]
526226008890	Lsr2; Region: Lsr2; pfam11774
526226008891	patatin-related protein; Region: TIGR03607
526226008892	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
526226008893	nucleophile elbow; other site
526226008894	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
526226008895	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
526226008896	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
526226008897	active site
526226008898	dimer interface [polypeptide binding]; other site
526226008899	non-prolyl cis peptide bond; other site
526226008900	insertion regions; other site
526226008901	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
526226008902	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526226008903	substrate binding pocket [chemical binding]; other site
526226008904	membrane-bound complex binding site; other site
526226008905	hinge residues; other site
526226008906	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
526226008907	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
526226008908	Walker A/P-loop; other site
526226008909	ATP binding site [chemical binding]; other site
526226008910	Q-loop/lid; other site
526226008911	ABC transporter signature motif; other site
526226008912	Walker B; other site
526226008913	D-loop; other site
526226008914	H-loop/switch region; other site
526226008915	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526226008916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226008917	putative PBP binding loops; other site
526226008918	dimer interface [polypeptide binding]; other site
526226008919	ABC-ATPase subunit interface; other site
526226008920	Predicted permeases [General function prediction only]; Region: RarD; COG2962
526226008921	EamA-like transporter family; Region: EamA; pfam00892
526226008922	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226008923	dimerization interface [polypeptide binding]; other site
526226008924	putative DNA binding site [nucleotide binding]; other site
526226008925	putative Zn2+ binding site [ion binding]; other site
526226008926	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
526226008927	putative hydrophobic ligand binding site [chemical binding]; other site
526226008928	RibD C-terminal domain; Region: RibD_C; cl17279
526226008929	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
526226008930	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
526226008931	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
526226008932	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526226008933	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226008934	Walker A/P-loop; other site
526226008935	ATP binding site [chemical binding]; other site
526226008936	Q-loop/lid; other site
526226008937	ABC transporter signature motif; other site
526226008938	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226008939	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226008940	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
526226008941	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
526226008942	Ribosomal RNA adenine dimethylases; Region: rADc; smart00650
526226008943	Fic family protein [Function unknown]; Region: COG3177
526226008944	Fic/DOC family; Region: Fic; pfam02661
526226008945	putative transposase OrfB; Reviewed; Region: PHA02517
526226008946	HTH-like domain; Region: HTH_21; pfam13276
526226008947	Integrase core domain; Region: rve; pfam00665
526226008948	Integrase core domain; Region: rve_3; pfam13683
526226008949	Transposase; Region: HTH_Tnp_1; cl17663
526226008950	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
526226008951	putative active site [active]
526226008952	Helix-turn-helix domain; Region: HTH_17; pfam12728
526226008953	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226008954	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
526226008955	active site
526226008956	Int/Topo IB signature motif; other site
526226008957	DNA binding site [nucleotide binding]
526226008958	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
526226008959	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
526226008960	catalytic residues [active]
526226008961	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
526226008962	phosphoglucomutase; Validated; Region: PRK07564
526226008963	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
526226008964	active site
526226008965	substrate binding site [chemical binding]; other site
526226008966	metal binding site [ion binding]; metal-binding site
526226008967	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526226008968	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
526226008969	nucleophilic elbow; other site
526226008970	catalytic triad; other site
526226008971	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
526226008972	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
526226008973	acyl-activating enzyme (AAE) consensus motif; other site
526226008974	putative AMP binding site [chemical binding]; other site
526226008975	putative active site [active]
526226008976	putative CoA binding site [chemical binding]; other site
526226008977	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526226008978	CoA-transferase family III; Region: CoA_transf_3; pfam02515
526226008979	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226008980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226008981	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
526226008982	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526226008983	active site
526226008984	alpha-galactosidase; Region: PLN02808; cl17638
526226008985	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
526226008986	SmpB-tmRNA interface; other site
526226008987	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
526226008988	FtsX-like permease family; Region: FtsX; pfam02687
526226008989	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
526226008990	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226008991	Walker A/P-loop; other site
526226008992	ATP binding site [chemical binding]; other site
526226008993	Q-loop/lid; other site
526226008994	ABC transporter signature motif; other site
526226008995	Walker B; other site
526226008996	D-loop; other site
526226008997	H-loop/switch region; other site
526226008998	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
526226008999	Mechanosensitive ion channel; Region: MS_channel; pfam00924
526226009000	peptide chain release factor 2; Validated; Region: prfB; PRK00578
526226009001	This domain is found in peptide chain release factors; Region: PCRF; smart00937
526226009002	RF-1 domain; Region: RF-1; pfam00472
526226009003	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
526226009004	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
526226009005	active site
526226009006	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526226009007	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226009008	active site
526226009009	metal binding site [ion binding]; metal-binding site
526226009010	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526226009011	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
526226009012	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
526226009013	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226009014	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226009015	active site
526226009016	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226009017	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226009018	active site
526226009019	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226009020	Ligand Binding Site [chemical binding]; other site
526226009021	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
526226009022	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
526226009023	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
526226009024	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226009025	MarR family; Region: MarR_2; pfam12802
526226009026	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226009027	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
526226009028	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226009029	Ligand Binding Site [chemical binding]; other site
526226009030	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526226009031	Histidine kinase; Region: HisKA_3; pfam07730
526226009032	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226009033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226009034	active site
526226009035	phosphorylation site [posttranslational modification]
526226009036	intermolecular recognition site; other site
526226009037	dimerization interface [polypeptide binding]; other site
526226009038	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226009039	DNA binding residues [nucleotide binding]
526226009040	dimerization interface [polypeptide binding]; other site
526226009041	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
526226009042	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
526226009043	active site
526226009044	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
526226009045	dimer interface [polypeptide binding]; other site
526226009046	non-prolyl cis peptide bond; other site
526226009047	insertion regions; other site
526226009048	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
526226009049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226009050	dimer interface [polypeptide binding]; other site
526226009051	conserved gate region; other site
526226009052	putative PBP binding loops; other site
526226009053	ABC-ATPase subunit interface; other site
526226009054	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
526226009055	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226009056	Walker A/P-loop; other site
526226009057	ATP binding site [chemical binding]; other site
526226009058	Q-loop/lid; other site
526226009059	ABC transporter signature motif; other site
526226009060	Walker B; other site
526226009061	D-loop; other site
526226009062	H-loop/switch region; other site
526226009063	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
526226009064	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
526226009065	Ferredoxin [Energy production and conversion]; Region: COG1146
526226009066	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
526226009067	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
526226009068	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526226009069	substrate binding pocket [chemical binding]; other site
526226009070	membrane-bound complex binding site; other site
526226009071	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526226009072	nudix motif; other site
526226009073	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226009074	putative substrate translocation pore; other site
526226009075	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226009076	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226009077	mce related protein; Region: MCE; pfam02470
526226009078	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
526226009079	hypothetical protein; Validated; Region: PRK00068
526226009080	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
526226009081	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526226009082	protein binding site [polypeptide binding]; other site
526226009083	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
526226009084	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
526226009085	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
526226009086	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
526226009087	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
526226009088	ABC1 family; Region: ABC1; pfam03109
526226009089	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
526226009090	active site
526226009091	ATP binding site [chemical binding]; other site
526226009092	Transcription factor WhiB; Region: Whib; pfam02467
526226009093	Part of AAA domain; Region: AAA_19; pfam13245
526226009094	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
526226009095	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
526226009096	Family description; Region: UvrD_C_2; pfam13538
526226009097	HRDC domain; Region: HRDC; pfam00570
526226009098	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
526226009099	catalytic residues [active]
526226009100	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
526226009101	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
526226009102	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
526226009103	putative NADH binding site [chemical binding]; other site
526226009104	putative active site [active]
526226009105	nudix motif; other site
526226009106	putative metal binding site [ion binding]; other site
526226009107	Ion channel; Region: Ion_trans_2; pfam07885
526226009108	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
526226009109	TrkA-N domain; Region: TrkA_N; pfam02254
526226009110	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
526226009111	Part of AAA domain; Region: AAA_19; pfam13245
526226009112	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
526226009113	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
526226009114	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
526226009115	Part of AAA domain; Region: AAA_19; pfam13245
526226009116	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
526226009117	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226009118	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226009119	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
526226009120	catalytic site [active]
526226009121	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
526226009122	active site
526226009123	DNA binding site [nucleotide binding]
526226009124	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
526226009125	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
526226009126	putative active site [active]
526226009127	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
526226009128	putative active site [active]
526226009129	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
526226009130	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
526226009131	active site
526226009132	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226009133	DNA binding site [nucleotide binding]
526226009134	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
526226009135	nitrite reductase subunit NirD; Provisional; Region: PRK14989
526226009136	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
526226009137	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
526226009138	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
526226009139	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
526226009140	TIGR02569 family protein; Region: TIGR02569_actnb
526226009141	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
526226009142	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
526226009143	ATP binding site [chemical binding]; other site
526226009144	substrate interface [chemical binding]; other site
526226009145	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
526226009146	active site residue [active]
526226009147	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
526226009148	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226009149	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226009150	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
526226009151	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
526226009152	dinuclear metal binding motif [ion binding]; other site
526226009153	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
526226009154	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526226009155	ATP binding site [chemical binding]; other site
526226009156	Mg++ binding site [ion binding]; other site
526226009157	motif III; other site
526226009158	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226009159	nucleotide binding region [chemical binding]; other site
526226009160	ATP-binding site [chemical binding]; other site
526226009161	PQQ-like domain; Region: PQQ_2; pfam13360
526226009162	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526226009163	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
526226009164	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226009165	Magnesium ion binding site [ion binding]; other site
526226009166	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
526226009167	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
526226009168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226009169	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226009170	Transcription factor WhiB; Region: Whib; pfam02467
526226009171	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
526226009172	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
526226009173	Histidine kinase; Region: HisKA_2; pfam07568
526226009174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226009175	ATP binding site [chemical binding]; other site
526226009176	Mg2+ binding site [ion binding]; other site
526226009177	G-X-G motif; other site
526226009178	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526226009179	carboxyltransferase (CT) interaction site; other site
526226009180	biotinylation site [posttranslational modification]; other site
526226009181	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
526226009182	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
526226009183	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226009184	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226009185	DNA binding residues [nucleotide binding]
526226009186	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
526226009187	putative deacylase active site [active]
526226009188	Uncharacterized conserved protein [Function unknown]; Region: COG2135
526226009189	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226009190	hydrophobic ligand binding site; other site
526226009191	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
526226009192	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
526226009193	putative NAD(P) binding site [chemical binding]; other site
526226009194	putative substrate binding site [chemical binding]; other site
526226009195	catalytic Zn binding site [ion binding]; other site
526226009196	structural Zn binding site [ion binding]; other site
526226009197	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226009198	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226009199	hypothetical protein; Provisional; Region: PRK06849
526226009200	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526226009201	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
526226009202	Isochorismatase family; Region: Isochorismatase; pfam00857
526226009203	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
526226009204	catalytic triad [active]
526226009205	conserved cis-peptide bond; other site
526226009206	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
526226009207	NADH(P)-binding; Region: NAD_binding_10; pfam13460
526226009208	NAD(P) binding site [chemical binding]; other site
526226009209	putative active site [active]
526226009210	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226009211	MarR family; Region: MarR; pfam01047
526226009212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226009213	putative substrate translocation pore; other site
526226009214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226009215	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
526226009216	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226009217	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
526226009218	P-loop; other site
526226009219	Magnesium ion binding site [ion binding]; other site
526226009220	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226009221	Magnesium ion binding site [ion binding]; other site
526226009222	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
526226009223	nudix motif; other site
526226009224	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
526226009225	putative hydrophobic ligand binding site [chemical binding]; other site
526226009226	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226009227	dimerization interface [polypeptide binding]; other site
526226009228	putative DNA binding site [nucleotide binding]; other site
526226009229	putative Zn2+ binding site [ion binding]; other site
526226009230	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526226009231	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
526226009232	putative NAD(P) binding site [chemical binding]; other site
526226009233	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526226009234	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526226009235	active site
526226009236	catalytic tetrad [active]
526226009237	aminotransferase; Validated; Region: PRK07337
526226009238	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226009239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226009240	homodimer interface [polypeptide binding]; other site
526226009241	catalytic residue [active]
526226009242	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
526226009243	Beta-lactamase; Region: Beta-lactamase; pfam00144
526226009244	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
526226009245	dimerization interface [polypeptide binding]; other site
526226009246	putative path to active site cavity [active]
526226009247	diiron center [ion binding]; other site
526226009248	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
526226009249	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226009250	catalytic loop [active]
526226009251	iron binding site [ion binding]; other site
526226009252	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212
526226009253	FAD binding pocket [chemical binding]; other site
526226009254	FAD binding motif [chemical binding]; other site
526226009255	phosphate binding motif [ion binding]; other site
526226009256	beta-alpha-beta structure motif; other site
526226009257	NAD binding pocket [chemical binding]; other site
526226009258	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
526226009259	dimerization interface [polypeptide binding]; other site
526226009260	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
526226009261	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
526226009262	active site
526226009263	Domain of unknown function DUF59; Region: DUF59; pfam01883
526226009264	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
526226009265	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
526226009266	NAD binding site [chemical binding]; other site
526226009267	substrate binding site [chemical binding]; other site
526226009268	catalytic Zn binding site [ion binding]; other site
526226009269	structural Zn binding site [ion binding]; other site
526226009270	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
526226009271	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
526226009272	ring oligomerisation interface [polypeptide binding]; other site
526226009273	ATP/Mg binding site [chemical binding]; other site
526226009274	stacking interactions; other site
526226009275	hinge regions; other site
526226009276	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
526226009277	Helix-turn-helix domain; Region: HTH_17; pfam12728
526226009278	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
526226009279	Citrate synthase; Region: Citrate_synt; pfam00285
526226009280	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
526226009281	dimer interface [polypeptide binding]; other site
526226009282	active site
526226009283	oxalacetate/citrate binding site [chemical binding]; other site
526226009284	citrylCoA binding site [chemical binding]; other site
526226009285	coenzyme A binding site [chemical binding]; other site
526226009286	catalytic triad [active]
526226009287	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
526226009288	Citrate synthase; Region: Citrate_synt; pfam00285
526226009289	oxalacetate binding site [chemical binding]; other site
526226009290	citrylCoA binding site [chemical binding]; other site
526226009291	coenzyme A binding site [chemical binding]; other site
526226009292	catalytic triad [active]
526226009293	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
526226009294	intersubunit interface [polypeptide binding]; other site
526226009295	active site
526226009296	Zn2+ binding site [ion binding]; other site
526226009297	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526226009298	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526226009299	substrate binding site [chemical binding]; other site
526226009300	ATP binding site [chemical binding]; other site
526226009301	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526226009302	FAD binding domain; Region: FAD_binding_4; pfam01565
526226009303	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226009304	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226009305	DNA binding residues [nucleotide binding]
526226009306	dimerization interface [polypeptide binding]; other site
526226009307	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226009308	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226009309	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
526226009310	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
526226009311	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226009312	active site
526226009313	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
526226009314	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
526226009315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226009316	NAD(P) binding site [chemical binding]; other site
526226009317	active site
526226009318	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
526226009319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226009320	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
526226009321	dimerization interface [polypeptide binding]; other site
526226009322	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
526226009323	Predicted esterase [General function prediction only]; Region: COG0627
526226009324	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526226009325	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526226009326	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526226009327	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526226009328	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
526226009329	molybdopterin cofactor binding site; other site
526226009330	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
526226009331	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
526226009332	selenium donor protein; Region: selD; TIGR00476
526226009333	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
526226009334	dimerization interface [polypeptide binding]; other site
526226009335	putative ATP binding site [chemical binding]; other site
526226009336	selenocysteine synthase; Provisional; Region: PRK04311
526226009337	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
526226009338	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526226009339	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
526226009340	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
526226009341	G1 box; other site
526226009342	putative GEF interaction site [polypeptide binding]; other site
526226009343	GTP/Mg2+ binding site [chemical binding]; other site
526226009344	Switch I region; other site
526226009345	G2 box; other site
526226009346	G3 box; other site
526226009347	Switch II region; other site
526226009348	G4 box; other site
526226009349	G5 box; other site
526226009350	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
526226009351	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
526226009352	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
526226009353	Bacterial PH domain; Region: DUF304; cl01348
526226009354	Bacterial PH domain; Region: DUF304; pfam03703
526226009355	Uncharacterized conserved protein [Function unknown]; Region: COG3349
526226009356	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226009357	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226009358	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226009359	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
526226009360	nudix motif; other site
526226009361	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226009362	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526226009363	active site
526226009364	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
526226009365	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
526226009366	hinge; other site
526226009367	active site
526226009368	Predicted GTPases [General function prediction only]; Region: COG1162
526226009369	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
526226009370	GTPase/Zn-binding domain interface [polypeptide binding]; other site
526226009371	GTP/Mg2+ binding site [chemical binding]; other site
526226009372	G4 box; other site
526226009373	G5 box; other site
526226009374	G1 box; other site
526226009375	Switch I region; other site
526226009376	G2 box; other site
526226009377	G3 box; other site
526226009378	Switch II region; other site
526226009379	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526226009380	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226009381	DNA-binding site [nucleotide binding]; DNA binding site
526226009382	UTRA domain; Region: UTRA; pfam07702
526226009383	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526226009384	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526226009385	DNA binding site [nucleotide binding]
526226009386	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
526226009387	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526226009388	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
526226009389	short chain dehydrogenase; Provisional; Region: PRK06198
526226009390	classical (c) SDRs; Region: SDR_c; cd05233
526226009391	NAD(P) binding site [chemical binding]; other site
526226009392	active site
526226009393	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526226009394	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226009395	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526226009396	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526226009397	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526226009398	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526226009399	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226009400	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526226009401	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526226009402	ligand binding site [chemical binding]; other site
526226009403	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
526226009404	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
526226009405	Walker A/P-loop; other site
526226009406	ATP binding site [chemical binding]; other site
526226009407	Q-loop/lid; other site
526226009408	ABC transporter signature motif; other site
526226009409	Walker B; other site
526226009410	D-loop; other site
526226009411	H-loop/switch region; other site
526226009412	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526226009413	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
526226009414	TM-ABC transporter signature motif; other site
526226009415	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
526226009416	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526226009417	putative ligand binding site [chemical binding]; other site
526226009418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226009419	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226009420	putative substrate translocation pore; other site
526226009421	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526226009422	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226009423	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526226009424	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526226009425	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
526226009426	substrate binding site [chemical binding]; other site
526226009427	ATP binding site [chemical binding]; other site
526226009428	KduI/IolB family; Region: KduI; pfam04962
526226009429	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
526226009430	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
526226009431	PYR/PP interface [polypeptide binding]; other site
526226009432	dimer interface [polypeptide binding]; other site
526226009433	TPP binding site [chemical binding]; other site
526226009434	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
526226009435	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
526226009436	TPP-binding site; other site
526226009437	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526226009438	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226009439	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526226009440	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
526226009441	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
526226009442	tetrameric interface [polypeptide binding]; other site
526226009443	NAD binding site [chemical binding]; other site
526226009444	catalytic residues [active]
526226009445	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526226009446	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526226009447	DNA binding site [nucleotide binding]
526226009448	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526226009449	ligand binding site [chemical binding]; other site
526226009450	dimerization interface [polypeptide binding]; other site
526226009451	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
526226009452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226009453	putative substrate translocation pore; other site
526226009454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226009455	Transposase; Region: HTH_Tnp_1; cl17663
526226009456	putative transposase OrfB; Reviewed; Region: PHA02517
526226009457	HTH-like domain; Region: HTH_21; pfam13276
526226009458	Integrase core domain; Region: rve; pfam00665
526226009459	Integrase core domain; Region: rve_3; pfam13683
526226009460	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
526226009461	heme bH binding site [chemical binding]; other site
526226009462	intrachain domain interface; other site
526226009463	heme bL binding site [chemical binding]; other site
526226009464	interchain domain interface [polypeptide binding]; other site
526226009465	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
526226009466	Qo binding site; other site
526226009467	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
526226009468	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
526226009469	putative di-iron ligands [ion binding]; other site
526226009470	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
526226009471	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
526226009472	putative di-iron ligands [ion binding]; other site
526226009473	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226009474	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526226009475	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226009476	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
526226009477	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
526226009478	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526226009479	FAD binding pocket [chemical binding]; other site
526226009480	FAD binding motif [chemical binding]; other site
526226009481	phosphate binding motif [ion binding]; other site
526226009482	beta-alpha-beta structure motif; other site
526226009483	NAD binding pocket [chemical binding]; other site
526226009484	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226009485	catalytic loop [active]
526226009486	iron binding site [ion binding]; other site
526226009487	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
526226009488	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
526226009489	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526226009490	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
526226009491	putative NAD(P) binding site [chemical binding]; other site
526226009492	catalytic Zn binding site [ion binding]; other site
526226009493	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
526226009494	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
526226009495	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
526226009496	nucleotide binding region [chemical binding]; other site
526226009497	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
526226009498	30S subunit binding site; other site
526226009499	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
526226009500	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
526226009501	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226009502	Cytochrome P450; Region: p450; cl12078
526226009503	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226009504	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
526226009505	catalytic loop [active]
526226009506	iron binding site [ion binding]; other site
526226009507	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
526226009508	FAD binding pocket [chemical binding]; other site
526226009509	FAD binding motif [chemical binding]; other site
526226009510	phosphate binding motif [ion binding]; other site
526226009511	beta-alpha-beta structure motif; other site
526226009512	NAD binding pocket [chemical binding]; other site
526226009513	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
526226009514	lipoprotein LpqB; Provisional; Region: PRK13616
526226009515	Sporulation and spore germination; Region: Germane; pfam10646
526226009516	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226009517	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526226009518	dimerization interface [polypeptide binding]; other site
526226009519	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226009520	dimer interface [polypeptide binding]; other site
526226009521	phosphorylation site [posttranslational modification]
526226009522	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226009523	ATP binding site [chemical binding]; other site
526226009524	Mg2+ binding site [ion binding]; other site
526226009525	G-X-G motif; other site
526226009526	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226009527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226009528	active site
526226009529	phosphorylation site [posttranslational modification]
526226009530	intermolecular recognition site; other site
526226009531	dimerization interface [polypeptide binding]; other site
526226009532	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226009533	DNA binding site [nucleotide binding]
526226009534	thymidylate kinase; Validated; Region: PRK07933
526226009535	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
526226009536	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
526226009537	homotetramer interface [polypeptide binding]; other site
526226009538	ligand binding site [chemical binding]; other site
526226009539	catalytic site [active]
526226009540	NAD binding site [chemical binding]; other site
526226009541	amino acid transporter; Region: 2A0306; TIGR00909
526226009542	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
526226009543	Cation efflux family; Region: Cation_efflux; pfam01545
526226009544	Proteins of 100 residues with WXG; Region: WXG100; cl02005
526226009545	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
526226009546	EspG family; Region: ESX-1_EspG; pfam14011
526226009547	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
526226009548	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
526226009549	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
526226009550	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
526226009551	ligand binding site [chemical binding]; other site
526226009552	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
526226009553	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226009554	Walker A/P-loop; other site
526226009555	ATP binding site [chemical binding]; other site
526226009556	Q-loop/lid; other site
526226009557	ABC transporter signature motif; other site
526226009558	Walker B; other site
526226009559	D-loop; other site
526226009560	H-loop/switch region; other site
526226009561	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
526226009562	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
526226009563	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
526226009564	active site
526226009565	non-prolyl cis peptide bond; other site
526226009566	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
526226009567	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
526226009568	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226009569	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226009570	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
526226009571	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
526226009572	dimerization interface 3.5A [polypeptide binding]; other site
526226009573	active site
526226009574	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
526226009575	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
526226009576	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
526226009577	alphaNTD homodimer interface [polypeptide binding]; other site
526226009578	alphaNTD - beta interaction site [polypeptide binding]; other site
526226009579	alphaNTD - beta' interaction site [polypeptide binding]; other site
526226009580	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
526226009581	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
526226009582	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
526226009583	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526226009584	RNA binding surface [nucleotide binding]; other site
526226009585	30S ribosomal protein S11; Validated; Region: PRK05309
526226009586	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
526226009587	30S ribosomal protein S13; Region: bact_S13; TIGR03631
526226009588	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
526226009589	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
526226009590	rRNA binding site [nucleotide binding]; other site
526226009591	predicted 30S ribosome binding site; other site
526226009592	Predicted membrane protein [Function unknown]; Region: COG1950
526226009593	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
526226009594	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
526226009595	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
526226009596	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
526226009597	putative active site [active]
526226009598	dimerization interface [polypeptide binding]; other site
526226009599	putative tRNAtyr binding site [nucleotide binding]; other site
526226009600	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
526226009601	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
526226009602	active site
526226009603	adenylate kinase; Reviewed; Region: adk; PRK00279
526226009604	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
526226009605	AMP-binding site [chemical binding]; other site
526226009606	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
526226009607	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
526226009608	SecY translocase; Region: SecY; pfam00344
526226009609	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
526226009610	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
526226009611	23S rRNA binding site [nucleotide binding]; other site
526226009612	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
526226009613	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
526226009614	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
526226009615	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
526226009616	5S rRNA interface [nucleotide binding]; other site
526226009617	L27 interface [polypeptide binding]; other site
526226009618	23S rRNA interface [nucleotide binding]; other site
526226009619	L5 interface [polypeptide binding]; other site
526226009620	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
526226009621	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
526226009622	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
526226009623	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
526226009624	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226009625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226009626	Methyltransferase domain; Region: Methyltransf_23; pfam13489
526226009627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226009628	S-adenosylmethionine binding site [chemical binding]; other site
526226009629	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
526226009630	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
526226009631	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
526226009632	Cupin domain; Region: Cupin_2; cl17218
526226009633	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
526226009634	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
526226009635	[4Fe-4S] binding site [ion binding]; other site
526226009636	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526226009637	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526226009638	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
526226009639	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
526226009640	molybdopterin cofactor binding site; other site
526226009641	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
526226009642	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
526226009643	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
526226009644	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
526226009645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226009646	putative substrate translocation pore; other site
526226009647	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
526226009648	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
526226009649	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
526226009650	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
526226009651	active site
526226009652	Zn binding site [ion binding]; other site
526226009653	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
526226009654	putative metal binding site [ion binding]; other site
526226009655	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
526226009656	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
526226009657	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
526226009658	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
526226009659	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
526226009660	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
526226009661	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
526226009662	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
526226009663	RNA binding site [nucleotide binding]; other site
526226009664	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
526226009665	Condensation domain; Region: Condensation; pfam00668
526226009666	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009667	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226009668	acyl-activating enzyme (AAE) consensus motif; other site
526226009669	AMP binding site [chemical binding]; other site
526226009670	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
526226009671	Condensation domain; Region: Condensation; pfam00668
526226009672	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226009673	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009674	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009675	acyl-activating enzyme (AAE) consensus motif; other site
526226009676	AMP binding site [chemical binding]; other site
526226009677	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009678	Condensation domain; Region: Condensation; pfam00668
526226009679	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226009680	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009681	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009682	acyl-activating enzyme (AAE) consensus motif; other site
526226009683	AMP binding site [chemical binding]; other site
526226009684	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009685	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
526226009686	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009687	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009688	acyl-activating enzyme (AAE) consensus motif; other site
526226009689	AMP binding site [chemical binding]; other site
526226009690	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
526226009692	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226009693	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
526226009694	Walker A/P-loop; other site
526226009695	ATP binding site [chemical binding]; other site
526226009696	Q-loop/lid; other site
526226009697	ABC transporter signature motif; other site
526226009698	Walker B; other site
526226009699	D-loop; other site
526226009700	H-loop/switch region; other site
526226009701	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526226009702	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
526226009703	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
526226009704	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226009705	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226009706	DNA binding residues [nucleotide binding]
526226009707	Anti-sigma-K factor rskA; Region: RskA; pfam10099
526226009708	Putative esterase; Region: Esterase; pfam00756
526226009709	S-formylglutathione hydrolase; Region: PLN02442
526226009710	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226009711	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226009712	DNA binding residues [nucleotide binding]
526226009713	dimerization interface [polypeptide binding]; other site
526226009714	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226009715	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226009716	DNA binding residues [nucleotide binding]
526226009717	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
526226009718	Pirin-related protein [General function prediction only]; Region: COG1741
526226009719	Pirin; Region: Pirin; pfam02678
526226009720	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
526226009721	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526226009722	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
526226009723	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
526226009724	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226009725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
526226009726	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009727	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226009728	acyl-activating enzyme (AAE) consensus motif; other site
526226009729	AMP binding site [chemical binding]; other site
526226009730	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009731	Condensation domain; Region: Condensation; pfam00668
526226009732	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
526226009733	Condensation domain; Region: Condensation; pfam00668
526226009734	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226009735	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009736	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009737	acyl-activating enzyme (AAE) consensus motif; other site
526226009738	AMP binding site [chemical binding]; other site
526226009739	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009740	Condensation domain; Region: Condensation; pfam00668
526226009741	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009742	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009743	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226009744	acyl-activating enzyme (AAE) consensus motif; other site
526226009745	AMP binding site [chemical binding]; other site
526226009746	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009747	Condensation domain; Region: Condensation; pfam00668
526226009748	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
526226009749	Condensation domain; Region: Condensation; pfam00668
526226009750	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009751	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226009752	acyl-activating enzyme (AAE) consensus motif; other site
526226009753	AMP binding site [chemical binding]; other site
526226009754	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009755	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
526226009756	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009757	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009758	acyl-activating enzyme (AAE) consensus motif; other site
526226009759	AMP binding site [chemical binding]; other site
526226009760	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009761	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009762	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226009763	acyl-activating enzyme (AAE) consensus motif; other site
526226009764	AMP binding site [chemical binding]; other site
526226009765	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009766	Condensation domain; Region: Condensation; pfam00668
526226009767	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226009768	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009769	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009770	acyl-activating enzyme (AAE) consensus motif; other site
526226009771	AMP binding site [chemical binding]; other site
526226009772	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009773	Condensation domain; Region: Condensation; pfam00668
526226009774	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
526226009775	Condensation domain; Region: Condensation; pfam00668
526226009776	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226009777	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009778	acyl-activating enzyme (AAE) consensus motif; other site
526226009779	AMP binding site [chemical binding]; other site
526226009780	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009781	peptide synthase; Provisional; Region: PRK12467
526226009782	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009783	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009784	acyl-activating enzyme (AAE) consensus motif; other site
526226009785	AMP binding site [chemical binding]; other site
526226009786	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009787	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009788	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009789	acyl-activating enzyme (AAE) consensus motif; other site
526226009790	AMP binding site [chemical binding]; other site
526226009791	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009792	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
526226009793	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009794	acyl-activating enzyme (AAE) consensus motif; other site
526226009795	AMP binding site [chemical binding]; other site
526226009796	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009797	peptide synthase; Provisional; Region: PRK12467
526226009798	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009799	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009800	acyl-activating enzyme (AAE) consensus motif; other site
526226009801	AMP binding site [chemical binding]; other site
526226009802	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009803	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009804	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009805	acyl-activating enzyme (AAE) consensus motif; other site
526226009806	AMP binding site [chemical binding]; other site
526226009807	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009808	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
526226009809	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226009810	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009811	acyl-activating enzyme (AAE) consensus motif; other site
526226009812	AMP binding site [chemical binding]; other site
526226009813	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009814	Condensation domain; Region: Condensation; pfam00668
526226009815	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226009816	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009817	Condensation domain; Region: Condensation; pfam00668
526226009818	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009819	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226009820	acyl-activating enzyme (AAE) consensus motif; other site
526226009821	AMP binding site [chemical binding]; other site
526226009822	Condensation domain; Region: Condensation; pfam00668
526226009823	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226009824	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009825	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
526226009826	acyl-activating enzyme (AAE) consensus motif; other site
526226009827	AMP binding site [chemical binding]; other site
526226009828	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226009829	Condensation domain; Region: Condensation; pfam00668
526226009830	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
526226009831	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
526226009832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226009833	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
526226009834	Walker A/P-loop; other site
526226009835	ATP binding site [chemical binding]; other site
526226009836	Q-loop/lid; other site
526226009837	ABC transporter signature motif; other site
526226009838	Walker B; other site
526226009839	D-loop; other site
526226009840	H-loop/switch region; other site
526226009841	ABC-2 type transporter; Region: ABC2_membrane; cl17235
526226009842	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526226009843	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
526226009844	ABC-2 type transporter; Region: ABC2_membrane; cl17235
526226009845	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
526226009846	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526226009847	active site
526226009848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226009849	Coenzyme A binding pocket [chemical binding]; other site
526226009850	MbtH-like protein; Region: MbtH; pfam03621
526226009851	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226009852	acyl-activating enzyme (AAE) consensus motif; other site
526226009853	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226009854	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226009855	active site
526226009856	ATP binding site [chemical binding]; other site
526226009857	substrate binding site [chemical binding]; other site
526226009858	activation loop (A-loop); other site
526226009859	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
526226009860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226009861	ATP binding site [chemical binding]; other site
526226009862	Mg2+ binding site [ion binding]; other site
526226009863	G-X-G motif; other site
526226009864	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
526226009865	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
526226009866	active site
526226009867	catalytic site [active]
526226009868	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
526226009869	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
526226009870	23S rRNA interface [nucleotide binding]; other site
526226009871	putative translocon interaction site; other site
526226009872	signal recognition particle (SRP54) interaction site; other site
526226009873	L23 interface [polypeptide binding]; other site
526226009874	trigger factor interaction site; other site
526226009875	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
526226009876	23S rRNA interface [nucleotide binding]; other site
526226009877	5S rRNA interface [nucleotide binding]; other site
526226009878	putative antibiotic binding site [chemical binding]; other site
526226009879	L25 interface [polypeptide binding]; other site
526226009880	L27 interface [polypeptide binding]; other site
526226009881	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
526226009882	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
526226009883	G-X-X-G motif; other site
526226009884	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
526226009885	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
526226009886	putative translocon binding site; other site
526226009887	protein-rRNA interface [nucleotide binding]; other site
526226009888	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
526226009889	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
526226009890	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
526226009891	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
526226009892	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
526226009893	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
526226009894	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
526226009895	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
526226009896	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
526226009897	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
526226009898	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
526226009899	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
526226009900	active site
526226009901	dimer interface [polypeptide binding]; other site
526226009902	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
526226009903	Ligand Binding Site [chemical binding]; other site
526226009904	Molecular Tunnel; other site
526226009905	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526226009906	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526226009907	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
526226009908	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
526226009909	Na binding site [ion binding]; other site
526226009910	putative substrate binding site [chemical binding]; other site
526226009911	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
526226009912	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
526226009913	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
526226009914	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226009915	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526226009916	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
526226009917	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
526226009918	active site
526226009919	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
526226009920	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526226009921	CoA-transferase family III; Region: CoA_transf_3; pfam02515
526226009922	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
526226009923	classical (c) SDRs; Region: SDR_c; cd05233
526226009924	NAD(P) binding site [chemical binding]; other site
526226009925	active site
526226009926	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
526226009927	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526226009928	phosphate binding site [ion binding]; other site
526226009929	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
526226009930	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226009931	FeS/SAM binding site; other site
526226009932	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
526226009933	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
526226009934	mycofactocin precursor; Region: mycofactocin; TIGR03969
526226009935	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
526226009936	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226009937	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
526226009938	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
526226009939	FAD binding pocket [chemical binding]; other site
526226009940	FAD binding motif [chemical binding]; other site
526226009941	phosphate binding motif [ion binding]; other site
526226009942	beta-alpha-beta structure motif; other site
526226009943	NAD(p) ribose binding residues [chemical binding]; other site
526226009944	NAD binding pocket [chemical binding]; other site
526226009945	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
526226009946	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226009947	catalytic loop [active]
526226009948	iron binding site [ion binding]; other site
526226009949	Predicted membrane protein [Function unknown]; Region: COG4270
526226009950	A new structural DNA glycosylase; Region: AlkD_like; cd06561
526226009951	active site
526226009952	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
526226009953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
526226009954	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226009955	amino acid transporter; Region: 2A0306; TIGR00909
526226009956	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
526226009957	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226009958	Ligand Binding Site [chemical binding]; other site
526226009959	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226009960	Ligand Binding Site [chemical binding]; other site
526226009961	short chain dehydrogenase; Provisional; Region: PRK07825
526226009962	classical (c) SDRs; Region: SDR_c; cd05233
526226009963	NAD(P) binding site [chemical binding]; other site
526226009964	active site
526226009965	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226009966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226009967	Cytochrome P450; Region: p450; cl12078
526226009968	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226009969	O-succinylbenzoate synthase; Provisional; Region: PRK02901
526226009970	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
526226009971	metal binding site [ion binding]; metal-binding site
526226009972	substrate binding pocket [chemical binding]; other site
526226009973	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
526226009974	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226009975	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226009976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226009977	non-specific DNA binding site [nucleotide binding]; other site
526226009978	salt bridge; other site
526226009979	sequence-specific DNA binding site [nucleotide binding]; other site
526226009980	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
526226009981	FOG: WD40 repeat [General function prediction only]; Region: COG2319
526226009982	structural tetrad; other site
526226009983	FOG: WD40 repeat [General function prediction only]; Region: COG2319
526226009984	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
526226009985	structural tetrad; other site
526226009986	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
526226009987	structural tetrad; other site
526226009988	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
526226009989	DNA binding residues [nucleotide binding]
526226009990	dimerization interface [polypeptide binding]; other site
526226009991	Predicted esterase [General function prediction only]; Region: COG0627
526226009992	Short C-terminal domain; Region: SHOCT; pfam09851
526226009993	elongation factor Tu; Reviewed; Region: PRK00049
526226009994	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
526226009995	G1 box; other site
526226009996	GEF interaction site [polypeptide binding]; other site
526226009997	GTP/Mg2+ binding site [chemical binding]; other site
526226009998	Switch I region; other site
526226009999	G2 box; other site
526226010000	G3 box; other site
526226010001	Switch II region; other site
526226010002	G4 box; other site
526226010003	G5 box; other site
526226010004	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
526226010005	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
526226010006	Antibiotic Binding Site [chemical binding]; other site
526226010007	elongation factor G; Reviewed; Region: PRK00007
526226010008	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
526226010009	G1 box; other site
526226010010	putative GEF interaction site [polypeptide binding]; other site
526226010011	GTP/Mg2+ binding site [chemical binding]; other site
526226010012	Switch I region; other site
526226010013	G2 box; other site
526226010014	G3 box; other site
526226010015	Switch II region; other site
526226010016	G4 box; other site
526226010017	G5 box; other site
526226010018	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
526226010019	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
526226010020	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
526226010021	30S ribosomal protein S7; Validated; Region: PRK05302
526226010022	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
526226010023	S17 interaction site [polypeptide binding]; other site
526226010024	S8 interaction site; other site
526226010025	16S rRNA interaction site [nucleotide binding]; other site
526226010026	streptomycin interaction site [chemical binding]; other site
526226010027	23S rRNA interaction site [nucleotide binding]; other site
526226010028	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
526226010029	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
526226010030	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
526226010031	putative catalytic site [active]
526226010032	putative phosphate binding site [ion binding]; other site
526226010033	active site
526226010034	metal binding site A [ion binding]; metal-binding site
526226010035	DNA binding site [nucleotide binding]
526226010036	putative AP binding site [nucleotide binding]; other site
526226010037	putative metal binding site B [ion binding]; other site
526226010038	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226010039	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
526226010040	substrate binding pocket [chemical binding]; other site
526226010041	catalytic triad [active]
526226010042	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
526226010043	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226010044	short chain dehydrogenase; Provisional; Region: PRK05650
526226010045	classical (c) SDRs; Region: SDR_c; cd05233
526226010046	NAD(P) binding site [chemical binding]; other site
526226010047	active site
526226010048	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
526226010049	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
526226010050	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526226010051	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526226010052	DNA binding residues [nucleotide binding]
526226010053	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
526226010054	HPP family; Region: HPP; pfam04982
526226010055	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
526226010056	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
526226010057	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526226010058	NAD(P) binding site [chemical binding]; other site
526226010059	catalytic residues [active]
526226010060	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
526226010061	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
526226010062	NAD binding site [chemical binding]; other site
526226010063	catalytic Zn binding site [ion binding]; other site
526226010064	substrate binding site [chemical binding]; other site
526226010065	structural Zn binding site [ion binding]; other site
526226010066	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
526226010067	catalytic triad [active]
526226010068	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010069	enoyl-CoA hydratase; Provisional; Region: PRK07827
526226010070	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226010071	substrate binding site [chemical binding]; other site
526226010072	oxyanion hole (OAH) forming residues; other site
526226010073	trimer interface [polypeptide binding]; other site
526226010074	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226010075	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226010076	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
526226010077	active site
526226010078	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
526226010079	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
526226010080	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526226010081	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
526226010082	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
526226010083	carboxyltransferase (CT) interaction site; other site
526226010084	biotinylation site [posttranslational modification]; other site
526226010085	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
526226010086	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
526226010087	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226010088	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226010089	active site
526226010090	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
526226010091	TIGR03084 family protein; Region: TIGR03084
526226010092	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
526226010093	Wyosine base formation; Region: Wyosine_form; pfam08608
526226010094	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526226010095	CoenzymeA binding site [chemical binding]; other site
526226010096	subunit interaction site [polypeptide binding]; other site
526226010097	PHB binding site; other site
526226010098	acyl-CoA synthetase; Validated; Region: PRK07867
526226010099	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226010100	acyl-activating enzyme (AAE) consensus motif; other site
526226010101	AMP binding site [chemical binding]; other site
526226010102	active site
526226010103	CoA binding site [chemical binding]; other site
526226010104	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
526226010105	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
526226010106	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226010107	Ecdysteroid kinase; Region: EcKinase; cl17738
526226010108	Phosphotransferase enzyme family; Region: APH; pfam01636
526226010109	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
526226010110	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010111	NAD(P) binding site [chemical binding]; other site
526226010112	active site
526226010113	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526226010114	classical (c) SDRs; Region: SDR_c; cd05233
526226010115	NAD(P) binding site [chemical binding]; other site
526226010116	active site
526226010117	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
526226010118	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
526226010119	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226010120	Cytochrome P450; Region: p450; cl12078
526226010121	short chain dehydrogenase; Provisional; Region: PRK07775
526226010122	classical (c) SDRs; Region: SDR_c; cd05233
526226010123	NAD(P) binding site [chemical binding]; other site
526226010124	active site
526226010125	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226010126	Cytochrome P450; Region: p450; cl12078
526226010127	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010128	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010129	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
526226010130	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
526226010131	NAD binding site [chemical binding]; other site
526226010132	catalytic residues [active]
526226010133	short chain dehydrogenase; Provisional; Region: PRK07774
526226010134	classical (c) SDRs; Region: SDR_c; cd05233
526226010135	NAD(P) binding site [chemical binding]; other site
526226010136	active site
526226010137	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
526226010138	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
526226010139	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
526226010140	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226010141	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
526226010142	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
526226010143	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
526226010144	acyl-CoA synthetase; Provisional; Region: PRK13382
526226010145	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
526226010146	acyl-activating enzyme (AAE) consensus motif; other site
526226010147	putative AMP binding site [chemical binding]; other site
526226010148	putative active site [active]
526226010149	putative CoA binding site [chemical binding]; other site
526226010150	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526226010151	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
526226010152	putative acyl-acceptor binding pocket; other site
526226010153	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
526226010154	CoenzymeA binding site [chemical binding]; other site
526226010155	subunit interaction site [polypeptide binding]; other site
526226010156	PHB binding site; other site
526226010157	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
526226010158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226010159	Walker A/P-loop; other site
526226010160	ATP binding site [chemical binding]; other site
526226010161	Q-loop/lid; other site
526226010162	ABC transporter signature motif; other site
526226010163	Walker B; other site
526226010164	D-loop; other site
526226010165	H-loop/switch region; other site
526226010166	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
526226010167	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
526226010168	TM-ABC transporter signature motif; other site
526226010169	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
526226010170	TM-ABC transporter signature motif; other site
526226010171	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
526226010172	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
526226010173	Walker A/P-loop; other site
526226010174	ATP binding site [chemical binding]; other site
526226010175	Q-loop/lid; other site
526226010176	ABC transporter signature motif; other site
526226010177	Walker B; other site
526226010178	D-loop; other site
526226010179	H-loop/switch region; other site
526226010180	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
526226010181	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
526226010182	putative ligand binding site [chemical binding]; other site
526226010183	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010184	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010185	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
526226010186	Amidohydrolase; Region: Amidohydro_4; pfam13147
526226010187	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
526226010188	active site
526226010189	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
526226010190	CoA-transferase family III; Region: CoA_transf_3; pfam02515
526226010191	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
526226010192	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
526226010193	Walker A/P-loop; other site
526226010194	ATP binding site [chemical binding]; other site
526226010195	Q-loop/lid; other site
526226010196	ABC transporter signature motif; other site
526226010197	Walker B; other site
526226010198	D-loop; other site
526226010199	H-loop/switch region; other site
526226010200	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526226010201	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
526226010202	substrate binding pocket [chemical binding]; other site
526226010203	membrane-bound complex binding site; other site
526226010204	hinge residues; other site
526226010205	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
526226010206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226010207	dimer interface [polypeptide binding]; other site
526226010208	conserved gate region; other site
526226010209	putative PBP binding loops; other site
526226010210	ABC-ATPase subunit interface; other site
526226010211	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
526226010212	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526226010213	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
526226010214	NAD(P) binding site [chemical binding]; other site
526226010215	Methyltransferase domain; Region: Methyltransf_24; pfam13578
526226010216	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526226010217	classical (c) SDRs; Region: SDR_c; cd05233
526226010218	NAD(P) binding site [chemical binding]; other site
526226010219	active site
526226010220	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226010221	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526226010222	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
526226010223	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226010224	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010225	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010226	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
526226010227	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226010228	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226010229	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
526226010230	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
526226010231	Protein of unknown function, DUF608; Region: DUF608; pfam04685
526226010232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226010233	S-adenosylmethionine binding site [chemical binding]; other site
526226010234	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226010235	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226010236	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
526226010237	4Fe-4S binding domain; Region: Fer4; pfam00037
526226010238	ferredoxin-NADP+ reductase; Region: PLN02852
526226010239	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226010240	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
526226010241	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226010242	active site 2 [active]
526226010243	active site 1 [active]
526226010244	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
526226010245	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
526226010246	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
526226010247	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
526226010248	RNA binding surface [nucleotide binding]; other site
526226010249	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
526226010250	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226010251	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226010252	active site
526226010253	allophanate hydrolase; Provisional; Region: PRK08186
526226010254	Amidase; Region: Amidase; cl11426
526226010255	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
526226010256	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
526226010257	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
526226010258	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
526226010259	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
526226010260	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
526226010261	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
526226010262	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
526226010263	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
526226010264	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010265	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010266	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
526226010267	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010268	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010269	WHG domain; Region: WHG; pfam13305
526226010270	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226010271	MarR family; Region: MarR; pfam01047
526226010272	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
526226010273	ABC1 family; Region: ABC1; pfam03109
526226010274	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226010275	Cytochrome P450; Region: p450; cl12078
526226010276	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010277	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010278	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
526226010279	putative active site [active]
526226010280	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
526226010281	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
526226010282	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226010283	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
526226010284	substrate binding pocket [chemical binding]; other site
526226010285	FAD binding site [chemical binding]; other site
526226010286	catalytic base [active]
526226010287	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
526226010288	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
526226010289	tetrameric interface [polypeptide binding]; other site
526226010290	NAD binding site [chemical binding]; other site
526226010291	catalytic residues [active]
526226010292	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526226010293	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226010294	catalytic core [active]
526226010295	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226010296	dimerization interface [polypeptide binding]; other site
526226010297	putative DNA binding site [nucleotide binding]; other site
526226010298	putative Zn2+ binding site [ion binding]; other site
526226010299	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
526226010300	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
526226010301	Sulfate transporter family; Region: Sulfate_transp; pfam00916
526226010302	Sulfate transporter family; Region: Sulfate_transp; pfam00916
526226010303	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
526226010304	NAD synthetase; Reviewed; Region: nadE; PRK02628
526226010305	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
526226010306	multimer interface [polypeptide binding]; other site
526226010307	active site
526226010308	catalytic triad [active]
526226010309	protein interface 1 [polypeptide binding]; other site
526226010310	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
526226010311	homodimer interface [polypeptide binding]; other site
526226010312	NAD binding pocket [chemical binding]; other site
526226010313	ATP binding pocket [chemical binding]; other site
526226010314	Mg binding site [ion binding]; other site
526226010315	active-site loop [active]
526226010316	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
526226010317	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
526226010318	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226010319	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526226010320	active site
526226010321	ATP binding site [chemical binding]; other site
526226010322	substrate binding site [chemical binding]; other site
526226010323	activation loop (A-loop); other site
526226010324	T surface-antigen of pili; Region: FctA; cl16948
526226010325	SnoaL-like domain; Region: SnoaL_4; pfam13577
526226010326	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
526226010327	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
526226010328	homodimer interface [polypeptide binding]; other site
526226010329	putative substrate binding pocket [chemical binding]; other site
526226010330	diiron center [ion binding]; other site
526226010331	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
526226010332	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
526226010333	FMN binding site [chemical binding]; other site
526226010334	active site
526226010335	catalytic residues [active]
526226010336	substrate binding site [chemical binding]; other site
526226010337	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
526226010338	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
526226010339	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
526226010340	PhoU domain; Region: PhoU; pfam01895
526226010341	PhoU domain; Region: PhoU; pfam01895
526226010342	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
526226010343	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
526226010344	Walker A/P-loop; other site
526226010345	ATP binding site [chemical binding]; other site
526226010346	Q-loop/lid; other site
526226010347	ABC transporter signature motif; other site
526226010348	Walker B; other site
526226010349	D-loop; other site
526226010350	H-loop/switch region; other site
526226010351	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
526226010352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226010353	dimer interface [polypeptide binding]; other site
526226010354	conserved gate region; other site
526226010355	putative PBP binding loops; other site
526226010356	ABC-ATPase subunit interface; other site
526226010357	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
526226010358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226010359	dimer interface [polypeptide binding]; other site
526226010360	conserved gate region; other site
526226010361	putative PBP binding loops; other site
526226010362	ABC-ATPase subunit interface; other site
526226010363	PBP superfamily domain; Region: PBP_like_2; cl17296
526226010364	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526226010365	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
526226010366	active site
526226010367	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
526226010368	active site
526226010369	catalytic residues [active]
526226010370	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
526226010371	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
526226010372	Probable Catalytic site; other site
526226010373	metal-binding site
526226010374	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
526226010375	putative catalytic site [active]
526226010376	putative metal binding site [ion binding]; other site
526226010377	putative phosphate binding site [ion binding]; other site
526226010378	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
526226010379	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226010380	Coenzyme A binding pocket [chemical binding]; other site
526226010381	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226010382	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226010383	DNA binding site [nucleotide binding]
526226010384	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
526226010385	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
526226010386	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
526226010387	active site residue [active]
526226010388	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
526226010389	active site residue [active]
526226010390	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
526226010391	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
526226010392	putative hydrophobic ligand binding site [chemical binding]; other site
526226010393	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
526226010394	heme-binding site [chemical binding]; other site
526226010395	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
526226010396	mce related protein; Region: MCE; pfam02470
526226010397	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226010398	mce related protein; Region: MCE; pfam02470
526226010399	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
526226010400	mce related protein; Region: MCE; pfam02470
526226010401	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226010402	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226010403	mce related protein; Region: MCE; pfam02470
526226010404	mce related protein; Region: MCE; pfam02470
526226010405	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226010406	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
526226010407	mce related protein; Region: MCE; pfam02470
526226010408	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
526226010409	Permease; Region: Permease; pfam02405
526226010410	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
526226010411	Permease; Region: Permease; pfam02405
526226010412	short chain dehydrogenase; Provisional; Region: PRK07791
526226010413	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010414	NAD(P) binding site [chemical binding]; other site
526226010415	active site
526226010416	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
526226010417	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226010418	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226010419	active site
526226010420	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226010421	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226010422	active site
526226010423	acyl-CoA synthetase; Validated; Region: PRK07867
526226010424	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226010425	acyl-activating enzyme (AAE) consensus motif; other site
526226010426	AMP binding site [chemical binding]; other site
526226010427	active site
526226010428	CoA binding site [chemical binding]; other site
526226010429	Nitronate monooxygenase; Region: NMO; pfam03060
526226010430	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
526226010431	FMN binding site [chemical binding]; other site
526226010432	substrate binding site [chemical binding]; other site
526226010433	putative catalytic residue [active]
526226010434	acyl-CoA synthetase; Validated; Region: PRK07798
526226010435	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226010436	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
526226010437	acyl-activating enzyme (AAE) consensus motif; other site
526226010438	acyl-activating enzyme (AAE) consensus motif; other site
526226010439	putative AMP binding site [chemical binding]; other site
526226010440	putative active site [active]
526226010441	putative CoA binding site [chemical binding]; other site
526226010442	enoyl-CoA hydratase; Provisional; Region: PRK07799
526226010443	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226010444	substrate binding site [chemical binding]; other site
526226010445	oxyanion hole (OAH) forming residues; other site
526226010446	trimer interface [polypeptide binding]; other site
526226010447	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
526226010448	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226010449	cytochrome P450 83B1; Provisional; Region: PLN03234
526226010450	Cytochrome P450; Region: p450; cl12078
526226010451	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226010452	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
526226010453	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
526226010454	DUF35 OB-fold domain; Region: DUF35; pfam01796
526226010455	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
526226010456	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
526226010457	DUF35 OB-fold domain; Region: DUF35; pfam01796
526226010458	lipid-transfer protein; Provisional; Region: PRK07937
526226010459	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
526226010460	active site
526226010461	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
526226010462	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
526226010463	active site
526226010464	Uncharacterized conserved protein [Function unknown]; Region: COG2128
526226010465	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
526226010466	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
526226010467	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226010468	Cytochrome P450; Region: p450; cl12078
526226010469	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
526226010470	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226010471	dimer interface [polypeptide binding]; other site
526226010472	active site
526226010473	Domain of unknown function (DUF385); Region: DUF385; pfam04075
526226010474	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010475	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010476	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226010477	Cytochrome P450; Region: p450; cl12078
526226010478	acyl-CoA synthetase; Validated; Region: PRK06188
526226010479	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
526226010480	putative active site [active]
526226010481	putative CoA binding site [chemical binding]; other site
526226010482	putative AMP binding site [chemical binding]; other site
526226010483	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
526226010484	primary dimer interface [polypeptide binding]; other site
526226010485	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
526226010486	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226010487	Coenzyme A binding pocket [chemical binding]; other site
526226010488	short chain dehydrogenase; Provisional; Region: PRK07791
526226010489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010490	NAD(P) binding site [chemical binding]; other site
526226010491	active site
526226010492	short chain dehydrogenase; Provisional; Region: PRK07856
526226010493	classical (c) SDRs; Region: SDR_c; cd05233
526226010494	NAD(P) binding site [chemical binding]; other site
526226010495	active site
526226010496	enoyl-CoA hydratase; Provisional; Region: PRK06495
526226010497	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226010498	substrate binding site [chemical binding]; other site
526226010499	oxyanion hole (OAH) forming residues; other site
526226010500	trimer interface [polypeptide binding]; other site
526226010501	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
526226010502	Coenzyme A transferase; Region: CoA_trans; cl17247
526226010503	Nitronate monooxygenase; Region: NMO; pfam03060
526226010504	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
526226010505	FMN binding site [chemical binding]; other site
526226010506	substrate binding site [chemical binding]; other site
526226010507	putative catalytic residue [active]
526226010508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010509	NADH(P)-binding; Region: NAD_binding_10; pfam13460
526226010510	NAD(P) binding site [chemical binding]; other site
526226010511	active site
526226010512	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526226010513	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010514	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010515	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226010516	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226010517	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
526226010518	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
526226010519	NAD(P) binding site [chemical binding]; other site
526226010520	catalytic residues [active]
526226010521	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
526226010522	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226010523	dimer interface [polypeptide binding]; other site
526226010524	active site
526226010525	short chain dehydrogenase; Provisional; Region: PRK07831
526226010526	classical (c) SDRs; Region: SDR_c; cd05233
526226010527	NAD(P) binding site [chemical binding]; other site
526226010528	active site
526226010529	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226010530	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
526226010531	active site
526226010532	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
526226010533	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226010534	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
526226010535	acyl-activating enzyme (AAE) consensus motif; other site
526226010536	putative AMP binding site [chemical binding]; other site
526226010537	putative active site [active]
526226010538	putative CoA binding site [chemical binding]; other site
526226010539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
526226010540	Predicted kinase [General function prediction only]; Region: COG0645
526226010541	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
526226010542	CGNR zinc finger; Region: zf-CGNR; pfam11706
526226010543	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
526226010544	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
526226010545	dimer interface [polypeptide binding]; other site
526226010546	putative anticodon binding site; other site
526226010547	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
526226010548	motif 1; other site
526226010549	dimer interface [polypeptide binding]; other site
526226010550	active site
526226010551	motif 2; other site
526226010552	motif 3; other site
526226010553	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526226010554	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526226010555	active site
526226010556	catalytic tetrad [active]
526226010557	pantothenate kinase; Reviewed; Region: PRK13318
526226010558	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
526226010559	tetramerization interface [polypeptide binding]; other site
526226010560	active site
526226010561	Pantoate-beta-alanine ligase; Region: PanC; cd00560
526226010562	pantoate--beta-alanine ligase; Region: panC; TIGR00018
526226010563	active site
526226010564	ATP-binding site [chemical binding]; other site
526226010565	pantoate-binding site; other site
526226010566	HXXH motif; other site
526226010567	Rossmann-like domain; Region: Rossmann-like; pfam10727
526226010568	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
526226010569	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226010570	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526226010571	active site
526226010572	ATP binding site [chemical binding]; other site
526226010573	substrate binding site [chemical binding]; other site
526226010574	activation loop (A-loop); other site
526226010575	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
526226010576	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
526226010577	catalytic center binding site [active]
526226010578	ATP binding site [chemical binding]; other site
526226010579	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
526226010580	homooctamer interface [polypeptide binding]; other site
526226010581	active site
526226010582	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
526226010583	dihydropteroate synthase; Region: DHPS; TIGR01496
526226010584	substrate binding pocket [chemical binding]; other site
526226010585	dimer interface [polypeptide binding]; other site
526226010586	inhibitor binding site; inhibition site
526226010587	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
526226010588	GTP cyclohydrolase I; Provisional; Region: PLN03044
526226010589	homodecamer interface [polypeptide binding]; other site
526226010590	active site
526226010591	putative catalytic site residues [active]
526226010592	zinc binding site [ion binding]; other site
526226010593	GTP-CH-I/GFRP interaction surface; other site
526226010594	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
526226010595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226010596	Walker A motif; other site
526226010597	ATP binding site [chemical binding]; other site
526226010598	Walker B motif; other site
526226010599	arginine finger; other site
526226010600	Peptidase family M41; Region: Peptidase_M41; pfam01434
526226010601	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226010602	active site
526226010603	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
526226010604	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
526226010605	Ligand Binding Site [chemical binding]; other site
526226010606	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
526226010607	putative hydrolase; Region: TIGR03624
526226010608	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
526226010609	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
526226010610	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
526226010611	dimer interface [polypeptide binding]; other site
526226010612	substrate binding site [chemical binding]; other site
526226010613	metal binding sites [ion binding]; metal-binding site
526226010614	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526226010615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226010616	putative substrate translocation pore; other site
526226010617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226010618	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226010619	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226010620	putative DNA binding site [nucleotide binding]; other site
526226010621	putative Zn2+ binding site [ion binding]; other site
526226010622	allantoicase; Provisional; Region: PRK13257
526226010623	Allantoicase repeat; Region: Allantoicase; pfam03561
526226010624	Allantoicase repeat; Region: Allantoicase; pfam03561
526226010625	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526226010626	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226010627	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226010628	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226010629	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226010630	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226010631	isochorismate synthase DhbC; Validated; Region: PRK06923
526226010632	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
526226010633	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
526226010634	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
526226010635	homodimer interface [polypeptide binding]; other site
526226010636	substrate-cofactor binding pocket; other site
526226010637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226010638	catalytic residue [active]
526226010639	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
526226010640	active site residue [active]
526226010641	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
526226010642	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
526226010643	intersubunit interface [polypeptide binding]; other site
526226010644	ferredoxin-NADP+ reductase; Region: PLN02852
526226010645	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226010646	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
526226010647	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526226010648	ABC-ATPase subunit  interface; other site
526226010649	dimer interface [polypeptide binding]; other site
526226010650	putative PBP binding regions; other site
526226010651	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
526226010652	ABC-ATPase subunit  interface; other site
526226010653	dimer interface [polypeptide binding]; other site
526226010654	putative PBP binding regions; other site
526226010655	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
526226010656	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
526226010657	Walker A/P-loop; other site
526226010658	ATP binding site [chemical binding]; other site
526226010659	Q-loop/lid; other site
526226010660	ABC transporter signature motif; other site
526226010661	Walker B; other site
526226010662	D-loop; other site
526226010663	H-loop/switch region; other site
526226010664	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
526226010665	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010666	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526226010667	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
526226010668	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
526226010669	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526226010670	dimerization interface [polypeptide binding]; other site
526226010671	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
526226010672	cyclase homology domain; Region: CHD; cd07302
526226010673	nucleotidyl binding site; other site
526226010674	metal binding site [ion binding]; metal-binding site
526226010675	dimer interface [polypeptide binding]; other site
526226010676	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
526226010677	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
526226010678	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
526226010679	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
526226010680	GDP-binding site [chemical binding]; other site
526226010681	ACT binding site; other site
526226010682	IMP binding site; other site
526226010683	Peptidase family M50; Region: Peptidase_M50; pfam02163
526226010684	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
526226010685	active site
526226010686	putative substrate binding region [chemical binding]; other site
526226010687	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526226010688	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226010689	active site
526226010690	short chain dehydrogenase; Provisional; Region: PRK05875
526226010691	classical (c) SDRs; Region: SDR_c; cd05233
526226010692	NAD(P) binding site [chemical binding]; other site
526226010693	active site
526226010694	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
526226010695	Predicted membrane protein [Function unknown]; Region: COG4129
526226010696	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
526226010697	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
526226010698	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
526226010699	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
526226010700	active site
526226010701	intersubunit interface [polypeptide binding]; other site
526226010702	zinc binding site [ion binding]; other site
526226010703	Na+ binding site [ion binding]; other site
526226010704	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
526226010705	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
526226010706	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
526226010707	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
526226010708	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
526226010709	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
526226010710	MOSC domain; Region: MOSC; pfam03473
526226010711	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
526226010712	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
526226010713	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226010714	active site
526226010715	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
526226010716	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
526226010717	NAD binding site [chemical binding]; other site
526226010718	ligand binding site [chemical binding]; other site
526226010719	catalytic site [active]
526226010720	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
526226010721	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
526226010722	conserved cys residue [active]
526226010723	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226010724	putative DNA binding site [nucleotide binding]; other site
526226010725	dimerization interface [polypeptide binding]; other site
526226010726	putative Zn2+ binding site [ion binding]; other site
526226010727	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
526226010728	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
526226010729	inhibitor-cofactor binding pocket; inhibition site
526226010730	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226010731	catalytic residue [active]
526226010732	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526226010733	FAD binding domain; Region: FAD_binding_4; pfam01565
526226010734	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526226010735	succinic semialdehyde dehydrogenase; Region: PLN02278
526226010736	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
526226010737	tetramerization interface [polypeptide binding]; other site
526226010738	NAD(P) binding site [chemical binding]; other site
526226010739	catalytic residues [active]
526226010740	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
526226010741	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
526226010742	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
526226010743	active site
526226010744	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
526226010745	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226010746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226010747	homodimer interface [polypeptide binding]; other site
526226010748	catalytic residue [active]
526226010749	putative transposase OrfB; Reviewed; Region: PHA02517
526226010750	HTH-like domain; Region: HTH_21; pfam13276
526226010751	Integrase core domain; Region: rve; pfam00665
526226010752	Integrase core domain; Region: rve_3; pfam13683
526226010753	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226010754	metabolite-proton symporter; Region: 2A0106; TIGR00883
526226010755	putative substrate translocation pore; other site
526226010756	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526226010757	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226010758	DNA-binding site [nucleotide binding]; DNA binding site
526226010759	FCD domain; Region: FCD; pfam07729
526226010760	Protein of unknown function (DUF3830); Region: DUF3830; pfam12903
526226010761	putative amidase; Provisional; Region: PRK06169
526226010762	Amidase; Region: Amidase; pfam01425
526226010763	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
526226010764	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
526226010765	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
526226010766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226010767	active site
526226010768	phosphorylation site [posttranslational modification]
526226010769	intermolecular recognition site; other site
526226010770	dimerization interface [polypeptide binding]; other site
526226010771	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226010772	DNA binding site [nucleotide binding]
526226010773	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
526226010774	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
526226010775	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
526226010776	Ligand Binding Site [chemical binding]; other site
526226010777	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
526226010778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226010779	dimer interface [polypeptide binding]; other site
526226010780	phosphorylation site [posttranslational modification]
526226010781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226010782	ATP binding site [chemical binding]; other site
526226010783	Mg2+ binding site [ion binding]; other site
526226010784	G-X-G motif; other site
526226010785	K+-transporting ATPase, c chain; Region: KdpC; cl00944
526226010786	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
526226010787	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226010788	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526226010789	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
526226010790	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
526226010791	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
526226010792	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
526226010793	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526226010794	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
526226010795	DNA binding residues [nucleotide binding]
526226010796	drug binding residues [chemical binding]; other site
526226010797	dimer interface [polypeptide binding]; other site
526226010798	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
526226010799	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
526226010800	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226010801	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226010802	DNA binding residues [nucleotide binding]
526226010803	dihydroxyacetone kinase; Provisional; Region: PRK14479
526226010804	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
526226010805	DAK2 domain; Region: Dak2; pfam02734
526226010806	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
526226010807	Clp amino terminal domain; Region: Clp_N; pfam02861
526226010808	Clp amino terminal domain; Region: Clp_N; pfam02861
526226010809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226010810	Walker A motif; other site
526226010811	ATP binding site [chemical binding]; other site
526226010812	Walker B motif; other site
526226010813	arginine finger; other site
526226010814	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
526226010815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226010816	Walker A motif; other site
526226010817	ATP binding site [chemical binding]; other site
526226010818	Walker B motif; other site
526226010819	arginine finger; other site
526226010820	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
526226010821	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
526226010822	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526226010823	active site
526226010824	metal binding site [ion binding]; metal-binding site
526226010825	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226010826	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
526226010827	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226010828	Cupin domain; Region: Cupin_2; cl17218
526226010829	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
526226010830	homotrimer interaction site [polypeptide binding]; other site
526226010831	putative active site [active]
526226010832	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
526226010833	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
526226010834	NAD(P) binding site [chemical binding]; other site
526226010835	catalytic residues [active]
526226010836	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226010837	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226010838	dimerization interface [polypeptide binding]; other site
526226010839	putative Zn2+ binding site [ion binding]; other site
526226010840	putative DNA binding site [nucleotide binding]; other site
526226010841	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
526226010842	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
526226010843	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
526226010844	NAD(P) binding pocket [chemical binding]; other site
526226010845	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
526226010846	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
526226010847	AsnC family; Region: AsnC_trans_reg; pfam01037
526226010848	amino acid transporter; Region: 2A0306; TIGR00909
526226010849	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
526226010850	short chain dehydrogenase; Provisional; Region: PRK06197
526226010851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010852	NAD(P) binding site [chemical binding]; other site
526226010853	active site
526226010854	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
526226010855	catalytic residues [active]
526226010856	dimer interface [polypeptide binding]; other site
526226010857	Histidine kinase; Region: HisKA_3; pfam07730
526226010858	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
526226010859	ATP binding site [chemical binding]; other site
526226010860	Mg2+ binding site [ion binding]; other site
526226010861	G-X-G motif; other site
526226010862	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226010863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226010864	active site
526226010865	phosphorylation site [posttranslational modification]
526226010866	intermolecular recognition site; other site
526226010867	dimerization interface [polypeptide binding]; other site
526226010868	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226010869	DNA binding residues [nucleotide binding]
526226010870	dimerization interface [polypeptide binding]; other site
526226010871	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526226010872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226010873	Walker A/P-loop; other site
526226010874	ATP binding site [chemical binding]; other site
526226010875	Q-loop/lid; other site
526226010876	ABC transporter signature motif; other site
526226010877	Walker B; other site
526226010878	D-loop; other site
526226010879	H-loop/switch region; other site
526226010880	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
526226010881	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
526226010882	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
526226010883	DNA binding site [nucleotide binding]
526226010884	active site
526226010885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010886	Uncharacterized conserved protein [Function unknown]; Region: COG3268
526226010887	NAD(P) binding site [chemical binding]; other site
526226010888	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
526226010889	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
526226010890	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
526226010891	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
526226010892	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
526226010893	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
526226010894	Fatty acid desaturase; Region: FA_desaturase; pfam00487
526226010895	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
526226010896	putative di-iron ligands [ion binding]; other site
526226010897	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
526226010898	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526226010899	FAD binding pocket [chemical binding]; other site
526226010900	FAD binding motif [chemical binding]; other site
526226010901	phosphate binding motif [ion binding]; other site
526226010902	beta-alpha-beta structure motif; other site
526226010903	NAD binding pocket [chemical binding]; other site
526226010904	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
526226010905	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226010906	catalytic loop [active]
526226010907	iron binding site [ion binding]; other site
526226010908	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
526226010909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010910	NAD(P) binding site [chemical binding]; other site
526226010911	active site
526226010912	CAAX protease self-immunity; Region: Abi; pfam02517
526226010913	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526226010914	metal ion-dependent adhesion site (MIDAS); other site
526226010915	benzoate transport; Region: 2A0115; TIGR00895
526226010916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226010917	putative substrate translocation pore; other site
526226010918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226010919	Isochorismatase family; Region: Isochorismatase; pfam00857
526226010920	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
526226010921	catalytic triad [active]
526226010922	conserved cis-peptide bond; other site
526226010923	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
526226010924	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
526226010925	conserved cys residue [active]
526226010926	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226010927	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226010928	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
526226010929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226010930	Walker A/P-loop; other site
526226010931	ATP binding site [chemical binding]; other site
526226010932	Q-loop/lid; other site
526226010933	ABC transporter signature motif; other site
526226010934	Walker B; other site
526226010935	D-loop; other site
526226010936	H-loop/switch region; other site
526226010937	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
526226010938	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226010939	hydrophobic ligand binding site; other site
526226010940	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226010941	dimerization interface [polypeptide binding]; other site
526226010942	putative DNA binding site [nucleotide binding]; other site
526226010943	putative Zn2+ binding site [ion binding]; other site
526226010944	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
526226010945	active site
526226010946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226010947	NAD(P) binding site [chemical binding]; other site
526226010948	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226010949	MarR family; Region: MarR_2; pfam12802
526226010950	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
526226010951	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
526226010952	catalytic residues [active]
526226010953	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
526226010954	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
526226010955	active site residue [active]
526226010956	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
526226010957	active site residue [active]
526226010958	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
526226010959	active site
526226010960	catalytic residues [active]
526226010961	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
526226010962	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526226010963	putative active site [active]
526226010964	putative metal binding site [ion binding]; other site
526226010965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226010966	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
526226010967	Walker A motif; other site
526226010968	ATP binding site [chemical binding]; other site
526226010969	Walker B motif; other site
526226010970	arginine finger; other site
526226010971	CCC1-related family of proteins; Region: CCC1_like; cl00278
526226010972	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
526226010973	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
526226010974	active site
526226010975	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
526226010976	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
526226010977	Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315
526226010978	active site
526226010979	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
526226010980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226010981	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
526226010982	dimerization interface [polypeptide binding]; other site
526226010983	substrate binding pocket [chemical binding]; other site
526226010984	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
526226010985	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
526226010986	iron-sulfur cluster [ion binding]; other site
526226010987	[2Fe-2S] cluster binding site [ion binding]; other site
526226010988	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
526226010989	putative alpha subunit interface [polypeptide binding]; other site
526226010990	putative active site [active]
526226010991	putative substrate binding site [chemical binding]; other site
526226010992	Fe binding site [ion binding]; other site
526226010993	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
526226010994	inter-subunit interface; other site
526226010995	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
526226010996	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226010997	catalytic loop [active]
526226010998	iron binding site [ion binding]; other site
526226010999	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
526226011000	FAD binding pocket [chemical binding]; other site
526226011001	FAD binding motif [chemical binding]; other site
526226011002	phosphate binding motif [ion binding]; other site
526226011003	beta-alpha-beta structure motif; other site
526226011004	NAD binding pocket [chemical binding]; other site
526226011005	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526226011006	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
526226011007	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
526226011008	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226011009	NAD(P) binding site [chemical binding]; other site
526226011010	active site
526226011011	AAA ATPase domain; Region: AAA_16; pfam13191
526226011012	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226011013	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226011014	DNA binding residues [nucleotide binding]
526226011015	dimerization interface [polypeptide binding]; other site
526226011016	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
526226011017	GIY-YIG motif/motif A; other site
526226011018	putative active site [active]
526226011019	putative metal binding site [ion binding]; other site
526226011020	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
526226011021	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
526226011022	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
526226011023	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
526226011024	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
526226011025	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226011026	dimer interface [polypeptide binding]; other site
526226011027	active site
526226011028	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
526226011029	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226011030	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
526226011031	dimerization interface [polypeptide binding]; other site
526226011032	substrate binding pocket [chemical binding]; other site
526226011033	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
526226011034	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
526226011035	substrate binding site [chemical binding]; other site
526226011036	ATP binding site [chemical binding]; other site
526226011037	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
526226011038	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
526226011039	Membrane protein of unknown function; Region: DUF360; pfam04020
526226011040	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
526226011041	enoyl-CoA hydratase; Provisional; Region: PRK05862
526226011042	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226011043	substrate binding site [chemical binding]; other site
526226011044	oxyanion hole (OAH) forming residues; other site
526226011045	trimer interface [polypeptide binding]; other site
526226011046	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
526226011047	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226011048	substrate binding site [chemical binding]; other site
526226011049	oxyanion hole (OAH) forming residues; other site
526226011050	trimer interface [polypeptide binding]; other site
526226011051	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
526226011052	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
526226011053	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
526226011054	FAD binding pocket [chemical binding]; other site
526226011055	FAD binding motif [chemical binding]; other site
526226011056	phosphate binding motif [ion binding]; other site
526226011057	NAD binding pocket [chemical binding]; other site
526226011058	Lsr2; Region: Lsr2; pfam11774
526226011059	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226011060	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
526226011061	NAD(P) binding site [chemical binding]; other site
526226011062	active site
526226011063	MarR family; Region: MarR_2; pfam12802
526226011064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011066	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
526226011067	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226011068	DNA-binding site [nucleotide binding]; DNA binding site
526226011069	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
526226011070	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226011071	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226011072	active site
526226011073	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226011074	active site 2 [active]
526226011075	active site 1 [active]
526226011076	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226011077	active site 2 [active]
526226011078	active site 1 [active]
526226011079	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
526226011080	CoA-transferase family III; Region: CoA_transf_3; pfam02515
526226011081	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526226011082	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226011083	DNA-binding site [nucleotide binding]; DNA binding site
526226011084	FCD domain; Region: FCD; pfam07729
526226011085	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226011086	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226011087	active site
526226011088	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526226011089	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226011090	NAD(P) binding site [chemical binding]; other site
526226011091	active site
526226011092	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526226011093	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011094	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011095	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226011096	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226011097	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
526226011098	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526226011099	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226011100	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526226011101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011102	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226011103	putative substrate translocation pore; other site
526226011104	Transcriptional regulators [Transcription]; Region: GntR; COG1802
526226011105	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226011106	DNA-binding site [nucleotide binding]; DNA binding site
526226011107	FCD domain; Region: FCD; cl11656
526226011108	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
526226011109	benzoate transporter; Region: benE; TIGR00843
526226011110	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
526226011111	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
526226011112	active site
526226011113	tetramer interface [polypeptide binding]; other site
526226011114	5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620
526226011115	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
526226011116	catalytic residue [active]
526226011117	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
526226011118	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165
526226011119	putative ligand binding site [chemical binding]; other site
526226011120	NAD binding site [chemical binding]; other site
526226011121	dimer interface [polypeptide binding]; other site
526226011122	putative catalytic site [active]
526226011123	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
526226011124	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
526226011125	putative ligand binding site [chemical binding]; other site
526226011126	NAD binding site [chemical binding]; other site
526226011127	catalytic site [active]
526226011128	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
526226011129	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226011130	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
526226011131	putative dimerization interface [polypeptide binding]; other site
526226011132	putative substrate binding pocket [chemical binding]; other site
526226011133	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526226011134	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526226011135	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
526226011136	methionine sulfoxide reductase A; Provisional; Region: PRK14054
526226011137	methionine sulfoxide reductase B; Provisional; Region: PRK00222
526226011138	SelR domain; Region: SelR; pfam01641
526226011139	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
526226011140	Fatty acid desaturase; Region: FA_desaturase; pfam00487
526226011141	Di-iron ligands [ion binding]; other site
526226011142	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
526226011143	Rubredoxin; Region: Rubredoxin; pfam00301
526226011144	iron binding site [ion binding]; other site
526226011145	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
526226011146	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
526226011147	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
526226011148	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
526226011149	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226011150	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
526226011151	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
526226011152	Universal stress protein family; Region: Usp; pfam00582
526226011153	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
526226011154	dihydroxyacetone kinase; Provisional; Region: PRK14479
526226011155	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
526226011156	DAK2 domain; Region: Dak2; pfam02734
526226011157	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
526226011158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226011159	NAD(P) binding site [chemical binding]; other site
526226011160	active site
526226011161	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526226011162	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226011163	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
526226011164	dimerization interface [polypeptide binding]; other site
526226011165	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
526226011166	Penicillinase repressor; Region: Pencillinase_R; pfam03965
526226011167	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226011168	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226011169	dimer interface [polypeptide binding]; other site
526226011170	phosphorylation site [posttranslational modification]
526226011171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226011172	ATP binding site [chemical binding]; other site
526226011173	Mg2+ binding site [ion binding]; other site
526226011174	G-X-G motif; other site
526226011175	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226011176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226011177	active site
526226011178	phosphorylation site [posttranslational modification]
526226011179	intermolecular recognition site; other site
526226011180	dimerization interface [polypeptide binding]; other site
526226011181	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226011182	DNA binding site [nucleotide binding]
526226011183	putative transposase OrfB; Reviewed; Region: PHA02517
526226011184	HTH-like domain; Region: HTH_21; pfam13276
526226011185	Integrase core domain; Region: rve; pfam00665
526226011186	Integrase core domain; Region: rve_3; pfam13683
526226011187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011188	putative substrate translocation pore; other site
526226011189	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526226011190	metal-binding site [ion binding]
526226011191	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
526226011192	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526226011193	metal-binding site [ion binding]
526226011194	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226011195	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
526226011196	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226011197	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526226011198	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
526226011199	putative homodimer interface [polypeptide binding]; other site
526226011200	putative homotetramer interface [polypeptide binding]; other site
526226011201	putative allosteric switch controlling residues; other site
526226011202	putative metal binding site [ion binding]; other site
526226011203	putative homodimer-homodimer interface [polypeptide binding]; other site
526226011204	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226011205	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226011206	Domain of unknown function (DUF305); Region: DUF305; pfam03713
526226011207	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
526226011208	Cation transport protein; Region: TrkH; pfam02386
526226011209	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
526226011210	TrkA-N domain; Region: TrkA_N; pfam02254
526226011211	TrkA-C domain; Region: TrkA_C; pfam02080
526226011212	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
526226011213	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226011214	Walker A motif; other site
526226011215	ATP binding site [chemical binding]; other site
526226011216	Walker B motif; other site
526226011217	arginine finger; other site
526226011218	Winged helix-turn helix; Region: HTH_29; pfam13551
526226011219	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
526226011220	Integrase core domain; Region: rve; pfam00665
526226011221	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
526226011222	active site
526226011223	catalytic triad [active]
526226011224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226011225	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
526226011226	Walker A motif; other site
526226011227	ATP binding site [chemical binding]; other site
526226011228	Walker B motif; other site
526226011229	arginine finger; other site
526226011230	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011231	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011232	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
526226011233	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226011234	active site
526226011235	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
526226011236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226011237	active site
526226011238	phosphorylation site [posttranslational modification]
526226011239	intermolecular recognition site; other site
526226011240	dimerization interface [polypeptide binding]; other site
526226011241	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
526226011242	DNA binding site [nucleotide binding]
526226011243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226011244	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
526226011245	dimerization interface [polypeptide binding]; other site
526226011246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
526226011247	dimer interface [polypeptide binding]; other site
526226011248	phosphorylation site [posttranslational modification]
526226011249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226011250	ATP binding site [chemical binding]; other site
526226011251	Mg2+ binding site [ion binding]; other site
526226011252	G-X-G motif; other site
526226011253	FAD binding domain; Region: FAD_binding_4; pfam01565
526226011254	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
526226011255	Domain of unknown function (DUF385); Region: DUF385; cl04387
526226011256	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226011257	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226011258	active site
526226011259	ATP binding site [chemical binding]; other site
526226011260	substrate binding site [chemical binding]; other site
526226011261	activation loop (A-loop); other site
526226011262	Amidohydrolase; Region: Amidohydro_2; pfam04909
526226011263	active site
526226011264	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
526226011265	heme-binding site [chemical binding]; other site
526226011266	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
526226011267	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
526226011268	FAD binding pocket [chemical binding]; other site
526226011269	FAD binding motif [chemical binding]; other site
526226011270	phosphate binding motif [ion binding]; other site
526226011271	beta-alpha-beta structure motif; other site
526226011272	NAD binding pocket [chemical binding]; other site
526226011273	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
526226011274	DNA binding residues [nucleotide binding]
526226011275	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526226011276	putative dimer interface [polypeptide binding]; other site
526226011277	chaperone protein DnaJ; Provisional; Region: PRK14279
526226011278	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
526226011279	HSP70 interaction site [polypeptide binding]; other site
526226011280	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
526226011281	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
526226011282	Zn binding sites [ion binding]; other site
526226011283	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
526226011284	dimer interface [polypeptide binding]; other site
526226011285	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
526226011286	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
526226011287	dimer interface [polypeptide binding]; other site
526226011288	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
526226011289	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
526226011290	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
526226011291	nucleotide binding site [chemical binding]; other site
526226011292	NEF interaction site [polypeptide binding]; other site
526226011293	SBD interface [polypeptide binding]; other site
526226011294	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011295	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
526226011296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226011297	Walker A motif; other site
526226011298	ATP binding site [chemical binding]; other site
526226011299	Walker B motif; other site
526226011300	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
526226011301	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011302	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011303	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
526226011304	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526226011305	putative NAD(P) binding site [chemical binding]; other site
526226011306	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
526226011307	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
526226011308	Uncharacterized conserved protein [Function unknown]; Region: COG3189
526226011309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011310	putative substrate translocation pore; other site
526226011311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011312	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
526226011313	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
526226011314	active site
526226011315	catalytic residues [active]
526226011316	enoyl-CoA hydratase; Provisional; Region: PRK12478
526226011317	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226011318	substrate binding site [chemical binding]; other site
526226011319	oxyanion hole (OAH) forming residues; other site
526226011320	trimer interface [polypeptide binding]; other site
526226011321	Homeodomain-like domain; Region: HTH_23; pfam13384
526226011322	Winged helix-turn helix; Region: HTH_29; pfam13551
526226011323	Homeodomain-like domain; Region: HTH_32; pfam13565
526226011324	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226011325	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226011326	PaaX-like protein; Region: PaaX; pfam07848
526226011327	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
526226011328	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
526226011329	hydroxyglutarate oxidase; Provisional; Region: PRK11728
526226011330	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
526226011331	iron-sulfur cluster [ion binding]; other site
526226011332	[2Fe-2S] cluster binding site [ion binding]; other site
526226011333	classical (c) SDRs; Region: SDR_c; cd05233
526226011334	NAD(P) binding site [chemical binding]; other site
526226011335	active site
526226011336	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226011337	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226011338	active site
526226011339	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
526226011340	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
526226011341	hydrophobic ligand binding site; other site
526226011342	short chain dehydrogenase; Provisional; Region: PRK06701
526226011343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226011344	NAD(P) binding site [chemical binding]; other site
526226011345	active site
526226011346	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
526226011347	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226011348	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
526226011349	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226011350	DNA binding residues [nucleotide binding]
526226011351	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
526226011352	anti sigma factor interaction site; other site
526226011353	regulatory phosphorylation site [posttranslational modification]; other site
526226011354	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526226011355	putative methyltransferase; Provisional; Region: PRK14967
526226011356	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226011357	S-adenosylmethionine binding site [chemical binding]; other site
526226011358	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
526226011359	GAF domain; Region: GAF; pfam01590
526226011360	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
526226011361	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
526226011362	Cutinase; Region: Cutinase; pfam01083
526226011363	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
526226011364	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
526226011365	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
526226011366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
526226011367	ATP binding site [chemical binding]; other site
526226011368	Mg2+ binding site [ion binding]; other site
526226011369	G-X-G motif; other site
526226011370	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226011371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226011372	active site
526226011373	phosphorylation site [posttranslational modification]
526226011374	intermolecular recognition site; other site
526226011375	dimerization interface [polypeptide binding]; other site
526226011376	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226011377	DNA binding residues [nucleotide binding]
526226011378	dimerization interface [polypeptide binding]; other site
526226011379	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
526226011380	YCII-related domain; Region: YCII; cl00999
526226011381	Competence-damaged protein; Region: CinA; pfam02464
526226011382	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
526226011383	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
526226011384	NAD binding site [chemical binding]; other site
526226011385	catalytic Zn binding site [ion binding]; other site
526226011386	structural Zn binding site [ion binding]; other site
526226011387	Cutinase; Region: Cutinase; pfam01083
526226011388	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
526226011389	XdhC Rossmann domain; Region: XdhC_C; pfam13478
526226011390	MoxR-like ATPases [General function prediction only]; Region: COG0714
526226011391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226011392	Walker A motif; other site
526226011393	ATP binding site [chemical binding]; other site
526226011394	Walker B motif; other site
526226011395	arginine finger; other site
526226011396	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
526226011397	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
526226011398	metal ion-dependent adhesion site (MIDAS); other site
526226011399	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
526226011400	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226011401	catalytic loop [active]
526226011402	iron binding site [ion binding]; other site
526226011403	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
526226011404	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
526226011405	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
526226011406	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
526226011407	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
526226011408	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
526226011409	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
526226011410	putative hydrophobic ligand binding site [chemical binding]; other site
526226011411	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
526226011412	FMN binding site [chemical binding]; other site
526226011413	dimer interface [polypeptide binding]; other site
526226011414	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
526226011415	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
526226011416	iron-sulfur cluster [ion binding]; other site
526226011417	[2Fe-2S] cluster binding site [ion binding]; other site
526226011418	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
526226011419	short chain dehydrogenase; Provisional; Region: PRK06197
526226011420	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226011421	NAD(P) binding site [chemical binding]; other site
526226011422	active site
526226011423	Acyltransferase family; Region: Acyl_transf_3; pfam01757
526226011424	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
526226011425	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
526226011426	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526226011427	putative active site [active]
526226011428	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
526226011429	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
526226011430	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526226011431	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
526226011432	Cysteine-rich domain; Region: CCG; pfam02754
526226011433	Cysteine-rich domain; Region: CCG; pfam02754
526226011434	aminotransferase AlaT; Validated; Region: PRK09265
526226011435	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226011436	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226011437	homodimer interface [polypeptide binding]; other site
526226011438	catalytic residue [active]
526226011439	short chain dehydrogenase; Validated; Region: PRK05855
526226011440	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
526226011441	classical (c) SDRs; Region: SDR_c; cd05233
526226011442	NAD(P) binding site [chemical binding]; other site
526226011443	active site
526226011444	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
526226011445	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
526226011446	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526226011447	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
526226011448	FMN-binding pocket [chemical binding]; other site
526226011449	flavin binding motif; other site
526226011450	phosphate binding motif [ion binding]; other site
526226011451	beta-alpha-beta structure motif; other site
526226011452	NAD binding pocket [chemical binding]; other site
526226011453	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226011454	catalytic loop [active]
526226011455	iron binding site [ion binding]; other site
526226011456	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
526226011457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011458	putative substrate translocation pore; other site
526226011459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011460	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011461	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011462	WHG domain; Region: WHG; pfam13305
526226011463	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526226011464	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
526226011465	DNA binding residues [nucleotide binding]
526226011466	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
526226011467	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
526226011468	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
526226011469	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
526226011470	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
526226011471	trimer interface [polypeptide binding]; other site
526226011472	active site
526226011473	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226011474	YCII-related domain; Region: YCII; cl00999
526226011475	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
526226011476	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
526226011477	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
526226011478	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
526226011479	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
526226011480	active site
526226011481	non-prolyl cis peptide bond; other site
526226011482	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
526226011483	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
526226011484	MspA; Region: MspA; pfam09203
526226011485	MspA; Region: MspA; pfam09203
526226011486	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
526226011487	Protein of unknown function DUF72; Region: DUF72; pfam01904
526226011488	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
526226011489	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226011490	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
526226011491	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
526226011492	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
526226011493	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
526226011494	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011495	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011496	guanine deaminase; Provisional; Region: PRK09228
526226011497	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
526226011498	active site
526226011499	ATP-grasp domain; Region: ATP-grasp_4; cl17255
526226011500	Homeodomain-like domain; Region: HTH_23; pfam13384
526226011501	Winged helix-turn helix; Region: HTH_29; pfam13551
526226011502	Homeodomain-like domain; Region: HTH_32; pfam13565
526226011503	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226011504	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226011505	SnoaL-like domain; Region: SnoaL_4; pfam13577
526226011506	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226011507	active site
526226011508	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
526226011509	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
526226011510	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
526226011511	Walker A/P-loop; other site
526226011512	ATP binding site [chemical binding]; other site
526226011513	Q-loop/lid; other site
526226011514	ABC transporter signature motif; other site
526226011515	Walker B; other site
526226011516	D-loop; other site
526226011517	H-loop/switch region; other site
526226011518	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
526226011519	ThiS interaction site; other site
526226011520	putative active site [active]
526226011521	tetramer interface [polypeptide binding]; other site
526226011522	Ubiquitin-like proteins; Region: UBQ; cl00155
526226011523	charged pocket; other site
526226011524	hydrophobic patch; other site
526226011525	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
526226011526	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
526226011527	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
526226011528	thiamine phosphate binding site [chemical binding]; other site
526226011529	active site
526226011530	pyrophosphate binding site [ion binding]; other site
526226011531	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
526226011532	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
526226011533	nudix motif; other site
526226011534	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
526226011535	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
526226011536	substrate binding pocket [chemical binding]; other site
526226011537	membrane-bound complex binding site; other site
526226011538	hinge residues; other site
526226011539	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
526226011540	Catalytic domain of Protein Kinases; Region: PKc; cd00180
526226011541	active site
526226011542	ATP binding site [chemical binding]; other site
526226011543	substrate binding site [chemical binding]; other site
526226011544	activation loop (A-loop); other site
526226011545	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
526226011546	propionate/acetate kinase; Provisional; Region: PRK12379
526226011547	phosphate acetyltransferase; Reviewed; Region: PRK05632
526226011548	DRTGG domain; Region: DRTGG; pfam07085
526226011549	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
526226011550	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
526226011551	FAD binding domain; Region: FAD_binding_4; pfam01565
526226011552	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011553	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011554	EamA-like transporter family; Region: EamA; pfam00892
526226011555	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
526226011556	EamA-like transporter family; Region: EamA; pfam00892
526226011557	Transcriptional regulator [Transcription]; Region: LysR; COG0583
526226011558	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226011559	putative DNA binding site [nucleotide binding]; other site
526226011560	putative Zn2+ binding site [ion binding]; other site
526226011561	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
526226011562	putative dimerization interface [polypeptide binding]; other site
526226011563	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
526226011564	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
526226011565	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226011566	Methyltransferase domain; Region: Methyltransf_23; pfam13489
526226011567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226011568	S-adenosylmethionine binding site [chemical binding]; other site
526226011569	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526226011570	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526226011571	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226011572	Walker A/P-loop; other site
526226011573	ATP binding site [chemical binding]; other site
526226011574	Q-loop/lid; other site
526226011575	ABC transporter signature motif; other site
526226011576	Walker B; other site
526226011577	D-loop; other site
526226011578	H-loop/switch region; other site
526226011579	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
526226011580	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226011581	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226011582	active site
526226011583	Domain of unknown function (DUF202); Region: DUF202; cl09954
526226011584	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
526226011585	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226011586	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
526226011587	acyl-activating enzyme (AAE) consensus motif; other site
526226011588	AMP binding site [chemical binding]; other site
526226011589	active site
526226011590	CoA binding site [chemical binding]; other site
526226011591	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
526226011592	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
526226011593	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
526226011594	putative trimer interface [polypeptide binding]; other site
526226011595	putative CoA binding site [chemical binding]; other site
526226011596	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
526226011597	putative trimer interface [polypeptide binding]; other site
526226011598	putative CoA binding site [chemical binding]; other site
526226011599	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
526226011600	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
526226011601	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
526226011602	Domain of unknown function (DUF305); Region: DUF305; pfam03713
526226011603	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
526226011604	active site
526226011605	endonuclease IV; Provisional; Region: PRK01060
526226011606	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
526226011607	DNA interaction; other site
526226011608	Metal-binding active site; metal-binding site
526226011609	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
526226011610	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
526226011611	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
526226011612	FAD binding site [chemical binding]; other site
526226011613	substrate binding site [chemical binding]; other site
526226011614	catalytic residues [active]
526226011615	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
526226011616	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
526226011617	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
526226011618	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526226011619	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
526226011620	protein binding site [polypeptide binding]; other site
526226011621	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
526226011622	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
526226011623	nucleotide binding site [chemical binding]; other site
526226011624	NEF interaction site [polypeptide binding]; other site
526226011625	SBD interface [polypeptide binding]; other site
526226011626	heat shock protein GrpE; Provisional; Region: PRK14140
526226011627	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
526226011628	dimer interface [polypeptide binding]; other site
526226011629	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
526226011630	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
526226011631	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
526226011632	HSP70 interaction site [polypeptide binding]; other site
526226011633	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
526226011634	substrate binding site [polypeptide binding]; other site
526226011635	dimer interface [polypeptide binding]; other site
526226011636	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
526226011637	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526226011638	DNA binding residues [nucleotide binding]
526226011639	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
526226011640	Clp amino terminal domain; Region: Clp_N; pfam02861
526226011641	Clp amino terminal domain; Region: Clp_N; pfam02861
526226011642	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226011643	Walker A motif; other site
526226011644	ATP binding site [chemical binding]; other site
526226011645	Walker B motif; other site
526226011646	arginine finger; other site
526226011647	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226011648	Walker A motif; other site
526226011649	ATP binding site [chemical binding]; other site
526226011650	Walker B motif; other site
526226011651	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
526226011652	Protein of unknown function (DUF2614); Region: DUF2614; cl07936
526226011653	thioredoxin 2; Provisional; Region: PRK10996
526226011654	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526226011655	catalytic residues [active]
526226011656	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
526226011657	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
526226011658	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
526226011659	ligand binding site [chemical binding]; other site
526226011660	flexible hinge region; other site
526226011661	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
526226011662	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226011663	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226011664	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
526226011665	Transposase; Region: DEDD_Tnp_IS110; pfam01548
526226011666	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
526226011667	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
526226011668	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
526226011669	putative metal binding site [ion binding]; other site
526226011670	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226011671	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
526226011672	NAD(P) binding site [chemical binding]; other site
526226011673	active site
526226011674	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
526226011675	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
526226011676	active site
526226011677	ATP binding site [chemical binding]; other site
526226011678	substrate binding site [chemical binding]; other site
526226011679	activation loop (A-loop); other site
526226011680	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226011681	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
526226011682	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226011683	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226011684	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226011685	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
526226011686	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
526226011687	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
526226011688	VanW like protein; Region: VanW; pfam04294
526226011689	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
526226011690	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226011691	dimer interface [polypeptide binding]; other site
526226011692	active site
526226011693	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
526226011694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226011695	NAD(P) binding site [chemical binding]; other site
526226011696	active site
526226011697	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226011698	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
526226011699	active site 2 [active]
526226011700	active site 1 [active]
526226011701	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011703	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
526226011704	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
526226011705	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
526226011706	Ligand Binding Site [chemical binding]; other site
526226011707	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
526226011708	Helix-turn-helix domain; Region: HTH_18; pfam12833
526226011709	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
526226011710	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
526226011711	conserved cys residue [active]
526226011712	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
526226011713	Acyltransferase family; Region: Acyl_transf_3; pfam01757
526226011714	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
526226011715	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
526226011716	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226011717	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
526226011718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226011719	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
526226011720	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
526226011721	FtsX-like permease family; Region: FtsX; pfam02687
526226011722	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
526226011723	FtsX-like permease family; Region: FtsX; pfam02687
526226011724	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
526226011725	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
526226011726	Walker A/P-loop; other site
526226011727	ATP binding site [chemical binding]; other site
526226011728	Q-loop/lid; other site
526226011729	ABC transporter signature motif; other site
526226011730	Walker B; other site
526226011731	D-loop; other site
526226011732	H-loop/switch region; other site
526226011733	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
526226011734	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
526226011735	active site
526226011736	substrate-binding site [chemical binding]; other site
526226011737	metal-binding site [ion binding]
526226011738	GTP binding site [chemical binding]; other site
526226011739	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
526226011740	G4 box; other site
526226011741	G5 box; other site
526226011742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226011743	S-adenosylmethionine binding site [chemical binding]; other site
526226011744	LabA_like proteins; Region: LabA_like/DUF88; cl10034
526226011745	putative metal binding site [ion binding]; other site
526226011746	MMPL family; Region: MMPL; pfam03176
526226011747	MMPL family; Region: MMPL; pfam03176
526226011748	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
526226011749	Domain of unknown function DUF20; Region: UPF0118; pfam01594
526226011750	Predicted integral membrane protein [Function unknown]; Region: COG0392
526226011751	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
526226011752	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
526226011753	Pirin; Region: Pirin; pfam02678
526226011754	Pirin-related protein [General function prediction only]; Region: COG1741
526226011755	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
526226011756	Transcriptional regulators [Transcription]; Region: FadR; COG2186
526226011757	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
526226011758	DNA-binding site [nucleotide binding]; DNA binding site
526226011759	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
526226011760	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226011761	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
526226011762	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
526226011763	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
526226011764	active site
526226011765	Zn binding site [ion binding]; other site
526226011766	Ion channel; Region: Ion_trans_2; pfam07885
526226011767	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
526226011768	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
526226011769	NAD binding site [chemical binding]; other site
526226011770	catalytic Zn binding site [ion binding]; other site
526226011771	substrate binding site [chemical binding]; other site
526226011772	structural Zn binding site [ion binding]; other site
526226011773	MMPL family; Region: MMPL; pfam03176
526226011774	Transport protein; Region: actII; TIGR00833
526226011775	ribonucleotide-diphosphate reductase subunit beta; Validated; Region: PRK08326
526226011776	dinuclear metal binding motif [ion binding]; other site
526226011777	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
526226011778	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526226011779	Walker A/P-loop; other site
526226011780	ATP binding site [chemical binding]; other site
526226011781	Q-loop/lid; other site
526226011782	ABC transporter signature motif; other site
526226011783	Walker B; other site
526226011784	D-loop; other site
526226011785	H-loop/switch region; other site
526226011786	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
526226011787	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
526226011788	Walker A/P-loop; other site
526226011789	ATP binding site [chemical binding]; other site
526226011790	Q-loop/lid; other site
526226011791	ABC transporter signature motif; other site
526226011792	Walker B; other site
526226011793	D-loop; other site
526226011794	H-loop/switch region; other site
526226011795	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
526226011796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226011797	dimer interface [polypeptide binding]; other site
526226011798	conserved gate region; other site
526226011799	putative PBP binding loops; other site
526226011800	ABC-ATPase subunit interface; other site
526226011801	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
526226011802	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
526226011803	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
526226011804	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
526226011805	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
526226011806	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
526226011807	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
526226011808	substrate binding site [chemical binding]; other site
526226011809	oxyanion hole (OAH) forming residues; other site
526226011810	trimer interface [polypeptide binding]; other site
526226011811	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
526226011812	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
526226011813	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
526226011814	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
526226011815	dimer interface [polypeptide binding]; other site
526226011816	active site
526226011817	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011818	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011819	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011820	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011821	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
526226011822	cyclase homology domain; Region: CHD; cd07302
526226011823	nucleotidyl binding site; other site
526226011824	metal binding site [ion binding]; metal-binding site
526226011825	dimer interface [polypeptide binding]; other site
526226011826	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226011827	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
526226011828	Walker A/P-loop; other site
526226011829	ATP binding site [chemical binding]; other site
526226011830	Q-loop/lid; other site
526226011831	ABC transporter signature motif; other site
526226011832	Walker B; other site
526226011833	D-loop; other site
526226011834	H-loop/switch region; other site
526226011835	TOBE domain; Region: TOBE; cl01440
526226011836	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
526226011837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
526226011838	dimer interface [polypeptide binding]; other site
526226011839	conserved gate region; other site
526226011840	putative PBP binding loops; other site
526226011841	ABC-ATPase subunit interface; other site
526226011842	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
526226011843	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
526226011844	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
526226011845	DNA binding residues [nucleotide binding]
526226011846	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
526226011847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226011848	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
526226011849	Walker A/P-loop; other site
526226011850	ATP binding site [chemical binding]; other site
526226011851	Q-loop/lid; other site
526226011852	ABC transporter signature motif; other site
526226011853	Walker B; other site
526226011854	D-loop; other site
526226011855	H-loop/switch region; other site
526226011856	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
526226011857	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
526226011858	MarR family; Region: MarR_2; pfam12802
526226011859	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
526226011860	RNA polymerase factor sigma-70; Validated; Region: PRK08241
526226011861	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226011862	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226011863	DNA binding residues [nucleotide binding]
526226011864	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
526226011865	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
526226011866	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226011867	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
526226011868	catalytic core [active]
526226011869	short chain dehydrogenase; Provisional; Region: PRK07454
526226011870	classical (c) SDRs; Region: SDR_c; cd05233
526226011871	NAD(P) binding site [chemical binding]; other site
526226011872	active site
526226011873	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
526226011874	Phosphotransferase enzyme family; Region: APH; pfam01636
526226011875	putative active site [active]
526226011876	putative substrate binding site [chemical binding]; other site
526226011877	ATP binding site [chemical binding]; other site
526226011878	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226011879	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226011880	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
526226011881	active site
526226011882	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226011883	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226011884	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526226011885	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
526226011886	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
526226011887	phosphate binding site [ion binding]; other site
526226011888	MMPL family; Region: MMPL; pfam03176
526226011889	MMPL family; Region: MMPL; pfam03176
526226011890	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
526226011891	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226011892	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
526226011893	Histidine kinase; Region: HisKA_3; pfam07730
526226011894	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226011895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226011896	active site
526226011897	phosphorylation site [posttranslational modification]
526226011898	intermolecular recognition site; other site
526226011899	dimerization interface [polypeptide binding]; other site
526226011900	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
526226011901	DNA binding residues [nucleotide binding]
526226011902	dimerization interface [polypeptide binding]; other site
526226011903	LysE type translocator; Region: LysE; cl00565
526226011904	H+ Antiporter protein; Region: 2A0121; TIGR00900
526226011905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226011906	putative substrate translocation pore; other site
526226011907	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
526226011908	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
526226011909	putative DNA binding site [nucleotide binding]; other site
526226011910	putative homodimer interface [polypeptide binding]; other site
526226011911	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
526226011912	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
526226011913	nucleotide binding site [chemical binding]; other site
526226011914	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
526226011915	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
526226011916	active site
526226011917	DNA binding site [nucleotide binding]
526226011918	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
526226011919	DNA binding site [nucleotide binding]
526226011920	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
526226011921	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
526226011922	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
526226011923	active site
526226011924	metal binding site [ion binding]; metal-binding site
526226011925	hexamer interface [polypeptide binding]; other site
526226011926	Uncharacterized conserved protein [Function unknown]; Region: COG1434
526226011927	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
526226011928	putative active site [active]
526226011929	DoxX-like family; Region: DoxX_2; pfam13564
526226011930	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
526226011931	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
526226011932	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
526226011933	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
526226011934	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
526226011935	ligand binding site [chemical binding]; other site
526226011936	homodimer interface [polypeptide binding]; other site
526226011937	NAD(P) binding site [chemical binding]; other site
526226011938	trimer interface B [polypeptide binding]; other site
526226011939	trimer interface A [polypeptide binding]; other site
526226011940	Homeodomain-like domain; Region: HTH_23; pfam13384
526226011941	Winged helix-turn helix; Region: HTH_29; pfam13551
526226011942	Homeodomain-like domain; Region: HTH_32; pfam13565
526226011943	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226011944	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226011945	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
526226011946	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
526226011947	Moco binding site; other site
526226011948	metal coordination site [ion binding]; other site
526226011949	hypothetical protein; Validated; Region: PRK07121
526226011950	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
526226011951	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
526226011952	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526226011953	metal-binding site [ion binding]
526226011954	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226011955	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
526226011956	metal-binding site [ion binding]
526226011957	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
526226011958	putative homodimer interface [polypeptide binding]; other site
526226011959	putative homotetramer interface [polypeptide binding]; other site
526226011960	putative allosteric switch controlling residues; other site
526226011961	putative metal binding site [ion binding]; other site
526226011962	putative homodimer-homodimer interface [polypeptide binding]; other site
526226011963	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
526226011964	L-aspartate oxidase; Provisional; Region: PRK06175
526226011965	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
526226011966	RibD C-terminal domain; Region: RibD_C; cl17279
526226011967	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
526226011968	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
526226011969	putative NAD(P) binding site [chemical binding]; other site
526226011970	putative substrate binding site [chemical binding]; other site
526226011971	catalytic Zn binding site [ion binding]; other site
526226011972	structural Zn binding site [ion binding]; other site
526226011973	dimer interface [polypeptide binding]; other site
526226011974	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
526226011975	ABC1 family; Region: ABC1; cl17513
526226011976	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
526226011977	Putative esterase; Region: Esterase; pfam00756
526226011978	S-formylglutathione hydrolase; Region: PLN02442
526226011979	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
526226011980	Amidase; Region: Amidase; cl11426
526226011981	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
526226011982	FAD binding domain; Region: FAD_binding_2; pfam00890
526226011983	RibD C-terminal domain; Region: RibD_C; cl17279
526226011984	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
526226011985	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
526226011986	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
526226011987	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526226011988	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226011989	Walker A/P-loop; other site
526226011990	ATP binding site [chemical binding]; other site
526226011991	Q-loop/lid; other site
526226011992	ABC transporter signature motif; other site
526226011993	Walker B; other site
526226011994	D-loop; other site
526226011995	H-loop/switch region; other site
526226011996	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
526226011997	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
526226011998	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
526226011999	Walker A/P-loop; other site
526226012000	ATP binding site [chemical binding]; other site
526226012001	Q-loop/lid; other site
526226012002	ABC transporter signature motif; other site
526226012003	Walker B; other site
526226012004	D-loop; other site
526226012005	H-loop/switch region; other site
526226012006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
526226012007	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
526226012008	short chain dehydrogenase; Provisional; Region: PRK07814
526226012009	classical (c) SDRs; Region: SDR_c; cd05233
526226012010	NAD(P) binding site [chemical binding]; other site
526226012011	active site
526226012012	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
526226012013	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
526226012014	active site
526226012015	catalytic tetrad [active]
526226012016	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
526226012017	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
526226012018	DNA binding residues [nucleotide binding]
526226012019	putative dimer interface [polypeptide binding]; other site
526226012020	Shikimate kinase; Region: SKI; pfam01202
526226012021	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
526226012022	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
526226012023	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
526226012024	putative ligand binding site [chemical binding]; other site
526226012025	putative NAD binding site [chemical binding]; other site
526226012026	catalytic site [active]
526226012027	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
526226012028	RNA/DNA hybrid binding site [nucleotide binding]; other site
526226012029	active site
526226012030	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
526226012031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226012032	S-adenosylmethionine binding site [chemical binding]; other site
526226012033	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
526226012034	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
526226012035	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
526226012036	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
526226012037	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
526226012038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
526226012039	Transposase; Region: DDE_Tnp_ISL3; pfam01610
526226012040	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226012041	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
526226012042	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
526226012043	active site
526226012044	Phosphotransferase enzyme family; Region: APH; pfam01636
526226012045	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
526226012046	putative active site [active]
526226012047	putative substrate binding site [chemical binding]; other site
526226012048	ATP binding site [chemical binding]; other site
526226012049	Transcriptional regulators [Transcription]; Region: MarR; COG1846
526226012050	MarR family; Region: MarR; pfam01047
526226012051	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
526226012052	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
526226012053	hydrophobic ligand binding site; other site
526226012054	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
526226012055	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
526226012056	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
526226012057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226012058	NAD(P) binding site [chemical binding]; other site
526226012059	active site
526226012060	Carboxylesterase family; Region: COesterase; pfam00135
526226012061	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
526226012062	substrate binding pocket [chemical binding]; other site
526226012063	catalytic triad [active]
526226012064	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
526226012065	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226012066	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
526226012067	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
526226012068	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
526226012069	Na binding site [ion binding]; other site
526226012070	putative substrate binding site [chemical binding]; other site
526226012071	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
526226012072	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
526226012073	tetrameric interface [polypeptide binding]; other site
526226012074	NAD binding site [chemical binding]; other site
526226012075	catalytic residues [active]
526226012076	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
526226012077	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226012078	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226012079	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226012080	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226012081	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
526226012082	putative active site [active]
526226012083	putative substrate binding site [chemical binding]; other site
526226012084	ATP binding site [chemical binding]; other site
526226012085	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
526226012086	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
526226012087	intracellular protease, PfpI family; Region: PfpI; TIGR01382
526226012088	proposed catalytic triad [active]
526226012089	conserved cys residue [active]
526226012090	Predicted membrane protein [Function unknown]; Region: COG1297
526226012091	putative oligopeptide transporter, OPT family; Region: TIGR00733
526226012092	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
526226012093	gating phenylalanine in ion channel; other site
526226012094	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
526226012095	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226012096	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226012097	classical (c) SDRs; Region: SDR_c; cd05233
526226012098	NAD(P) binding site [chemical binding]; other site
526226012099	active site
526226012100	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
526226012101	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
526226012102	putative ligand binding site [chemical binding]; other site
526226012103	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
526226012104	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
526226012105	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
526226012106	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
526226012107	Transcriptional regulators [Transcription]; Region: PurR; COG1609
526226012108	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
526226012109	DNA binding site [nucleotide binding]
526226012110	domain linker motif; other site
526226012111	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
526226012112	dimerization interface [polypeptide binding]; other site
526226012113	ligand binding site [chemical binding]; other site
526226012114	MarR family; Region: MarR_2; pfam12802
526226012115	Transcriptional regulators [Transcription]; Region: MarR; COG1846
526226012116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226012117	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226012118	putative substrate translocation pore; other site
526226012119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226012120	putative transposase OrfB; Reviewed; Region: PHA02517
526226012121	HTH-like domain; Region: HTH_21; pfam13276
526226012122	Integrase core domain; Region: rve; pfam00665
526226012123	Integrase core domain; Region: rve_3; pfam13683
526226012124	competence damage-inducible protein A; Provisional; Region: PRK00549
526226012125	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
526226012126	putative MPT binding site; other site
526226012127	Competence-damaged protein; Region: CinA; pfam02464
526226012128	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
526226012129	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
526226012130	Soluble P-type ATPase [General function prediction only]; Region: COG4087
526226012131	acyl-CoA synthetase; Validated; Region: PRK07788
526226012132	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226012133	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226012134	acyl-activating enzyme (AAE) consensus motif; other site
526226012135	AMP binding site [chemical binding]; other site
526226012136	active site
526226012137	CoA binding site [chemical binding]; other site
526226012138	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
526226012139	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
526226012140	MspA; Region: MspA; pfam09203
526226012141	MspA; Region: MspA; pfam09203
526226012142	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226012143	DNA binding residues [nucleotide binding]
526226012144	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
526226012145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
526226012146	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
526226012147	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
526226012148	dimerization interface [polypeptide binding]; other site
526226012149	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
526226012150	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
526226012151	NADP binding site [chemical binding]; other site
526226012152	dimer interface [polypeptide binding]; other site
526226012153	Domain of unknown function (DUF385); Region: DUF385; pfam04075
526226012154	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226012155	MarR family; Region: MarR_2; pfam12802
526226012156	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
526226012157	active site residue [active]
526226012158	Short C-terminal domain; Region: SHOCT; pfam09851
526226012159	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
526226012160	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
526226012161	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
526226012162	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
526226012163	conserved cys residue [active]
526226012164	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
526226012165	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
526226012166	conserved cys residue [active]
526226012167	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
526226012168	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
526226012169	threonine synthase; Validated; Region: PRK06260
526226012170	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
526226012171	homodimer interface [polypeptide binding]; other site
526226012172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226012173	catalytic residue [active]
526226012174	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
526226012175	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
526226012176	putative acyl-acceptor binding pocket; other site
526226012177	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
526226012178	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
526226012179	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
526226012180	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
526226012181	putative acyl-acceptor binding pocket; other site
526226012182	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
526226012183	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
526226012184	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226012185	FAD dependent oxidoreductase; Region: DAO; pfam01266
526226012186	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226012187	Transposase; Region: HTH_Tnp_1; cl17663
526226012188	putative transposase OrfB; Reviewed; Region: PHA02517
526226012189	HTH-like domain; Region: HTH_21; pfam13276
526226012190	Integrase core domain; Region: rve; pfam00665
526226012191	Integrase core domain; Region: rve_3; pfam13683
526226012192	putative transposase OrfB; Reviewed; Region: PHA02517
526226012193	HTH-like domain; Region: HTH_21; pfam13276
526226012194	Integrase core domain; Region: rve; pfam00665
526226012195	Integrase core domain; Region: rve_3; pfam13683
526226012196	Transposase; Region: HTH_Tnp_1; cl17663
526226012197	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
526226012198	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
526226012199	active site
526226012200	glutamate dehydrogenase; Provisional; Region: PRK09414
526226012201	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
526226012202	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
526226012203	NAD(P) binding site [chemical binding]; other site
526226012204	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
526226012205	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
526226012206	putative dimer interface [polypeptide binding]; other site
526226012207	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
526226012208	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
526226012209	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
526226012210	potential catalytic triad [active]
526226012211	conserved cys residue [active]
526226012212	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226012213	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226012214	WHG domain; Region: WHG; pfam13305
526226012215	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
526226012216	Cytochrome P450; Region: p450; cl12078
526226012217	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226012218	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226012219	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
526226012220	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
526226012221	SWIM zinc finger; Region: SWIM; pfam04434
526226012222	MoxR-like ATPases [General function prediction only]; Region: COG0714
526226012223	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
526226012224	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
526226012225	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
526226012226	metal ion-dependent adhesion site (MIDAS); other site
526226012227	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
526226012228	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
526226012229	Predicted amidohydrolase [General function prediction only]; Region: COG0388
526226012230	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
526226012231	active site
526226012232	catalytic triad [active]
526226012233	dimer interface [polypeptide binding]; other site
526226012234	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
526226012235	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
526226012236	AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050
526226012237	dimerization interface [polypeptide binding]; other site
526226012238	putative ATP binding site [chemical binding]; other site
526226012239	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
526226012240	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
526226012241	FeS/SAM binding site; other site
526226012242	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
526226012243	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226012244	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
526226012245	Predicted amidohydrolase [General function prediction only]; Region: COG0388
526226012246	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
526226012247	active site
526226012248	catalytic triad [active]
526226012249	dimer interface [polypeptide binding]; other site
526226012250	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
526226012251	Homeodomain-like domain; Region: HTH_23; pfam13384
526226012252	Winged helix-turn helix; Region: HTH_29; pfam13551
526226012253	Homeodomain-like domain; Region: HTH_32; pfam13565
526226012254	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226012255	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226012256	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
526226012257	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
526226012258	Transposase [DNA replication, recombination, and repair]; Region: COG5421
526226012259	putative transposase OrfB; Reviewed; Region: PHA02517
526226012260	HTH-like domain; Region: HTH_21; pfam13276
526226012261	Integrase core domain; Region: rve; pfam00665
526226012262	Integrase core domain; Region: rve_3; pfam13683
526226012263	Transposase; Region: HTH_Tnp_1; cl17663
526226012264	CHAT domain; Region: CHAT; cl17868
526226012265	Transposase; Region: HTH_Tnp_1; pfam01527
526226012266	putative transposase OrfB; Reviewed; Region: PHA02517
526226012267	HTH-like domain; Region: HTH_21; pfam13276
526226012268	Integrase core domain; Region: rve; pfam00665
526226012269	Integrase core domain; Region: rve_3; pfam13683
526226012270	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226012271	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226012272	TniQ; Region: TniQ; pfam06527
526226012273	AAA domain; Region: AAA_22; pfam13401
526226012274	Bacterial TniB protein; Region: TniB; pfam05621
526226012275	Integrase core domain; Region: rve; pfam00665
526226012276	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
526226012277	Protein of unknown function, DUF488; Region: DUF488; pfam04343
526226012278	Methyltransferase domain; Region: Methyltransf_26; pfam13659
526226012279	Methyltransferase domain; Region: Methyltransf_26; pfam13659
526226012280	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
526226012281	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
526226012282	active site
526226012283	catalytic residues [active]
526226012284	DNA binding site [nucleotide binding]
526226012285	Int/Topo IB signature motif; other site
526226012286	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
526226012287	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
526226012288	active site
526226012289	DNA binding site [nucleotide binding]
526226012290	Int/Topo IB signature motif; other site
526226012291	Transposase; Region: HTH_Tnp_1; cl17663
526226012292	multiple promoter invertase; Provisional; Region: mpi; PRK13413
526226012293	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
526226012294	catalytic residues [active]
526226012295	catalytic nucleophile [active]
526226012296	Presynaptic Site I dimer interface [polypeptide binding]; other site
526226012297	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
526226012298	Synaptic Flat tetramer interface [polypeptide binding]; other site
526226012299	Synaptic Site I dimer interface [polypeptide binding]; other site
526226012300	DNA binding site [nucleotide binding]
526226012301	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
526226012302	DNA-binding interface [nucleotide binding]; DNA binding site
526226012303	putative transposase OrfB; Reviewed; Region: PHA02517
526226012304	HTH-like domain; Region: HTH_21; pfam13276
526226012305	Integrase core domain; Region: rve; pfam00665
526226012306	Integrase core domain; Region: rve_3; pfam13683
526226012307	Transposase; Region: HTH_Tnp_1; cl17663
526226012308	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
526226012309	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
526226012310	Walker A motif; other site
526226012311	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
526226012312	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
526226012313	ATP binding site [chemical binding]; other site
526226012314	Walker B motif; other site
526226012315	DNA binding loops [nucleotide binding]
526226012316	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
526226012317	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
526226012318	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
526226012319	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
526226012320	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
526226012321	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
526226012322	dimer interface [polypeptide binding]; other site
526226012323	ssDNA binding site [nucleotide binding]; other site
526226012324	tetramer (dimer of dimers) interface [polypeptide binding]; other site
526226012325	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
526226012326	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
526226012327	Predicted integral membrane protein [Function unknown]; Region: COG5650
526226012328	Transglycosylase; Region: Transgly; pfam00912
526226012329	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
526226012330	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
526226012331	Predicted transcriptional regulators [Transcription]; Region: COG1695
526226012332	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
526226012333	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
526226012334	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
526226012335	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
526226012336	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
526226012337	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
526226012338	putative metal binding site [ion binding]; other site
526226012339	hypothetical protein; Provisional; Region: PRK14013
526226012340	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
526226012341	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
526226012342	putative metal binding site [ion binding]; other site
526226012343	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
526226012344	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
526226012345	nucleotide binding site [chemical binding]; other site
526226012346	putative NEF/HSP70 interaction site [polypeptide binding]; other site
526226012347	SBD interface [polypeptide binding]; other site
526226012348	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
526226012349	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
526226012350	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
526226012351	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
526226012352	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
526226012353	active site
526226012354	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
526226012355	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
526226012356	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
526226012357	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
526226012358	putative metal binding site [ion binding]; other site
526226012359	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
526226012360	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
526226012361	putative metal binding site [ion binding]; other site
526226012362	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
526226012363	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
526226012364	putative NAD(P) binding site [chemical binding]; other site
526226012365	Homeodomain-like domain; Region: HTH_23; pfam13384
526226012366	Winged helix-turn helix; Region: HTH_29; pfam13551
526226012367	Homeodomain-like domain; Region: HTH_32; pfam13565
526226012368	DDE superfamily endonuclease; Region: DDE_3; pfam13358
526226012369	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
526226012370	aconitate hydratase; Validated; Region: PRK07229
526226012371	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
526226012372	substrate binding site [chemical binding]; other site
526226012373	ligand binding site [chemical binding]; other site
526226012374	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
526226012375	substrate binding site [chemical binding]; other site
526226012376	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
526226012377	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
526226012378	active site
526226012379	catalytic site [active]
526226012380	substrate binding site [chemical binding]; other site
526226012381	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
526226012382	Dimer interface [polypeptide binding]; other site
526226012383	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
526226012384	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
526226012385	putative metal binding site [ion binding]; other site
526226012386	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
526226012387	active site
526226012388	phosphorylation site [posttranslational modification]
526226012389	intermolecular recognition site; other site
526226012390	dimerization interface [polypeptide binding]; other site
526226012391	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
526226012392	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
526226012393	DNA binding residues [nucleotide binding]
526226012394	dimerization interface [polypeptide binding]; other site
526226012395	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226012396	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
526226012397	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
526226012398	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
526226012399	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
526226012400	acyl-CoA synthetase; Validated; Region: PRK07787
526226012401	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
526226012402	acyl-activating enzyme (AAE) consensus motif; other site
526226012403	AMP binding site [chemical binding]; other site
526226012404	active site
526226012405	CoA binding site [chemical binding]; other site
526226012406	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226012407	active site
526226012408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
526226012409	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
526226012410	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
526226012411	Uncharacterized conserved protein [Function unknown]; Region: COG1262
526226012412	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226012413	Coenzyme A binding pocket [chemical binding]; other site
526226012414	Protein of unknown function (DUF429); Region: DUF429; cl12046
526226012415	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
526226012416	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
526226012417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226012418	catalytic residue [active]
526226012419	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
526226012420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
526226012421	active site
526226012422	phosphorylation site [posttranslational modification]
526226012423	intermolecular recognition site; other site
526226012424	dimerization interface [polypeptide binding]; other site
526226012425	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
526226012426	putative DNA binding site [nucleotide binding]; other site
526226012427	putative Zn2+ binding site [ion binding]; other site
526226012428	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
526226012429	Citrate transporter; Region: CitMHS; pfam03600
526226012430	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
526226012431	Citrate transporter; Region: CitMHS; pfam03600
526226012432	DNA polymerase IV; Validated; Region: PRK03858
526226012433	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
526226012434	active site
526226012435	DNA binding site [nucleotide binding]
526226012436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226012437	S-adenosylmethionine binding site [chemical binding]; other site
526226012438	CGNR zinc finger; Region: zf-CGNR; pfam11706
526226012439	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
526226012440	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
526226012441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
526226012442	homodimer interface [polypeptide binding]; other site
526226012443	catalytic residue [active]
526226012444	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
526226012445	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
526226012446	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
526226012447	Repair protein; Region: Repair_PSII; pfam04536
526226012448	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
526226012449	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
526226012450	MarR family; Region: MarR; pfam01047
526226012451	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
526226012452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226012453	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226012454	putative substrate translocation pore; other site
526226012455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
526226012456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226012457	putative substrate translocation pore; other site
526226012458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
526226012459	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226012460	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226012461	non-specific DNA binding site [nucleotide binding]; other site
526226012462	salt bridge; other site
526226012463	sequence-specific DNA binding site [nucleotide binding]; other site
526226012464	Cupin domain; Region: Cupin_2; pfam07883
526226012465	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
526226012466	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
526226012467	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226012468	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
526226012469	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
526226012470	active site
526226012471	FMN binding site [chemical binding]; other site
526226012472	substrate binding site [chemical binding]; other site
526226012473	3Fe-4S cluster binding site [ion binding]; other site
526226012474	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
526226012475	domain_subunit interface; other site
526226012476	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
526226012477	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
526226012478	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
526226012479	active site
526226012480	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
526226012481	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
526226012482	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
526226012483	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
526226012484	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
526226012485	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526226012486	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
526226012487	FMN-binding pocket [chemical binding]; other site
526226012488	flavin binding motif; other site
526226012489	phosphate binding motif [ion binding]; other site
526226012490	beta-alpha-beta structure motif; other site
526226012491	NAD binding pocket [chemical binding]; other site
526226012492	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226012493	catalytic loop [active]
526226012494	iron binding site [ion binding]; other site
526226012495	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
526226012496	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
526226012497	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
526226012498	FMN-binding pocket [chemical binding]; other site
526226012499	flavin binding motif; other site
526226012500	phosphate binding motif [ion binding]; other site
526226012501	beta-alpha-beta structure motif; other site
526226012502	NAD binding pocket [chemical binding]; other site
526226012503	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
526226012504	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
526226012505	catalytic loop [active]
526226012506	iron binding site [ion binding]; other site
526226012507	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
526226012508	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
526226012509	short chain dehydrogenase; Provisional; Region: PRK08219
526226012510	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
526226012511	NAD(P) binding site [chemical binding]; other site
526226012512	active site
526226012513	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
526226012514	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
526226012515	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
526226012516	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
526226012517	MoxR-like ATPases [General function prediction only]; Region: COG0714
526226012518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
526226012519	Walker A motif; other site
526226012520	ATP binding site [chemical binding]; other site
526226012521	Walker B motif; other site
526226012522	arginine finger; other site
526226012523	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
526226012524	Protein of unknown function DUF58; Region: DUF58; pfam01882
526226012525	Integral membrane protein DUF95; Region: DUF95; pfam01944
526226012526	Domain of unknown function (DUF222); Region: DUF222; pfam02720
526226012527	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
526226012528	active site
526226012529	RDD family; Region: RDD; pfam06271
526226012530	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
526226012531	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
526226012532	active site
526226012533	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
526226012534	HIT family signature motif; other site
526226012535	catalytic residue [active]
526226012536	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
526226012537	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526226012538	active site
526226012539	HIGH motif; other site
526226012540	nucleotide binding site [chemical binding]; other site
526226012541	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
526226012542	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526226012543	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526226012544	active site
526226012545	KMSKS motif; other site
526226012546	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
526226012547	tRNA binding surface [nucleotide binding]; other site
526226012548	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
526226012549	SdpI/YhfL protein family; Region: SdpI; pfam13630
526226012550	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
526226012551	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
526226012552	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
526226012553	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
526226012554	hypothetical protein; Validated; Region: PRK00228
526226012555	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
526226012556	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
526226012557	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
526226012558	catalytic residue [active]
526226012559	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
526226012560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226012561	diacylglycerol kinase; Reviewed; Region: PRK11914
526226012562	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
526226012563	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
526226012564	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
526226012565	active site
526226012566	NTP binding site [chemical binding]; other site
526226012567	metal binding triad [ion binding]; metal-binding site
526226012568	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
526226012569	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
526226012570	Zn2+ binding site [ion binding]; other site
526226012571	Mg2+ binding site [ion binding]; other site
526226012572	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
526226012573	active site
526226012574	Ap6A binding site [chemical binding]; other site
526226012575	nudix motif; other site
526226012576	metal binding site [ion binding]; metal-binding site
526226012577	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
526226012578	MviN-like protein; Region: MVIN; pfam03023
526226012579	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
526226012580	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
526226012581	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
526226012582	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
526226012583	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
526226012584	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
526226012585	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
526226012586	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
526226012587	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
526226012588	Coenzyme A binding pocket [chemical binding]; other site
526226012589	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
526226012590	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
526226012591	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
526226012592	DNA binding residues [nucleotide binding]
526226012593	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
526226012594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
526226012595	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
526226012596	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
526226012597	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
526226012598	catalytic residues [active]
526226012599	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
526226012600	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526226012601	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
526226012602	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
526226012603	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
526226012604	active site
526226012605	metal binding site [ion binding]; metal-binding site
526226012606	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
526226012607	ParB-like nuclease domain; Region: ParBc; pfam02195
526226012608	KorB domain; Region: KorB; pfam08535
526226012609	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526226012610	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226012611	P-loop; other site
526226012612	Magnesium ion binding site [ion binding]; other site
526226012613	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226012614	Magnesium ion binding site [ion binding]; other site
526226012615	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
526226012616	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
526226012617	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
526226012618	G-X-X-G motif; other site
526226012619	R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297
526226012620	RxxxH motif; other site
526226012621	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
526226012622	Haemolytic domain; Region: Haemolytic; pfam01809
526226012623	Ribonuclease P; Region: Ribonuclease_P; cl00457
526226012624	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
526226012625	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
526226012626	Cutinase; Region: Cutinase; pfam01083
526226012627	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226012628	non-specific DNA binding site [nucleotide binding]; other site
526226012629	salt bridge; other site
526226012630	sequence-specific DNA binding site [nucleotide binding]; other site
526226012631	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
526226012632	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
526226012633	non-specific DNA binding site [nucleotide binding]; other site
526226012634	salt bridge; other site
526226012635	sequence-specific DNA binding site [nucleotide binding]; other site
526226012636	Amidohydrolase; Region: Amidohydro_2; pfam04909
526226012637	Cytochrome P450; Region: p450; cl12078
526226012638	ferulate 5-hydroxylase; Region: PLN02183
526226012639	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
526226012640	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226012641	P-loop; other site
526226012642	Magnesium ion binding site [ion binding]; other site
526226012643	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
526226012644	Magnesium ion binding site [ion binding]; other site
526226012645	CAAX protease self-immunity; Region: Abi; pfam02517
526226012646	RES domain; Region: RES; pfam08808
526226012647	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
526226012648	Phosphotransferase enzyme family; Region: APH; pfam01636
526226012649	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
526226012650	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
526226012651	putative transposase OrfB; Reviewed; Region: PHA02517
526226012652	HTH-like domain; Region: HTH_21; pfam13276
526226012653	Integrase core domain; Region: rve; pfam00665
526226012654	Integrase core domain; Region: rve_3; pfam13683
526226012655	Transposase; Region: HTH_Tnp_1; pfam01527
526226012656	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
526226012657	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
526226012658	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
526226012659	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
526226012660	Helix-turn-helix domain; Region: HTH_19; pfam12844
526226012661	non-specific DNA binding site [nucleotide binding]; other site
526226012662	salt bridge; other site
526226012663	sequence-specific DNA binding site [nucleotide binding]; other site
526226012664	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
526226012665	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
526226012666	cofactor binding site; other site
526226012667	DNA binding site [nucleotide binding]
526226012668	substrate interaction site [chemical binding]; other site
526226012669	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
526226012670	catalytic residues [active]
526226012671	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
526226012672	Staphylococcal nuclease homologue; Region: SNase; pfam00565
526226012673	Catalytic site; other site
526226012674	TrwC relaxase; Region: TrwC; pfam08751
526226012675	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
526226012676	AAA domain; Region: AAA_30; pfam13604
526226012677	Family description; Region: UvrD_C_2; pfam13538
526226012678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
526226012679	S-adenosylmethionine binding site [chemical binding]; other site
526226012680	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
526226012681	DEAD-like helicases superfamily; Region: DEXDc; smart00487
526226012682	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
526226012683	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
526226012684	nucleotide binding region [chemical binding]; other site
526226012685	ATP-binding site [chemical binding]; other site
526226012686	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
526226012687	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
526226012688	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
526226012689	Peptidase family M23; Region: Peptidase_M23; pfam01551
526226012690	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
526226012691	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
526226012692	N-acetyl-D-glucosamine binding site [chemical binding]; other site
526226012693	catalytic residue [active]
526226012694	AAA-like domain; Region: AAA_10; pfam12846