-- dump date 20140619_103735 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1112204000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1112204000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204000003 Walker A motif; other site 1112204000004 ATP binding site [chemical binding]; other site 1112204000005 Walker B motif; other site 1112204000006 arginine finger; other site 1112204000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1112204000008 DnaA box-binding interface [nucleotide binding]; other site 1112204000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1112204000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1112204000011 putative DNA binding surface [nucleotide binding]; other site 1112204000012 dimer interface [polypeptide binding]; other site 1112204000013 beta-clamp/clamp loader binding surface; other site 1112204000014 beta-clamp/translesion DNA polymerase binding surface; other site 1112204000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1112204000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1112204000017 recombination protein F; Reviewed; Region: recF; PRK00064 1112204000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1112204000019 Walker A/P-loop; other site 1112204000020 ATP binding site [chemical binding]; other site 1112204000021 Q-loop/lid; other site 1112204000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204000023 ABC transporter signature motif; other site 1112204000024 Walker B; other site 1112204000025 D-loop; other site 1112204000026 H-loop/switch region; other site 1112204000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 1112204000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1112204000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204000030 ATP binding site [chemical binding]; other site 1112204000031 Mg2+ binding site [ion binding]; other site 1112204000032 G-X-G motif; other site 1112204000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1112204000034 anchoring element; other site 1112204000035 dimer interface [polypeptide binding]; other site 1112204000036 ATP binding site [chemical binding]; other site 1112204000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1112204000038 active site 1112204000039 putative metal-binding site [ion binding]; other site 1112204000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1112204000041 DNA gyrase subunit A; Validated; Region: PRK05560 1112204000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1112204000043 CAP-like domain; other site 1112204000044 active site 1112204000045 primary dimer interface [polypeptide binding]; other site 1112204000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1112204000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1112204000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1112204000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1112204000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1112204000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1112204000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1112204000053 WHG domain; Region: WHG; pfam13305 1112204000054 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1112204000055 Cutinase; Region: Cutinase; pfam01083 1112204000056 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1112204000057 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1112204000058 active site 1112204000059 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1112204000060 putative septation inhibitor protein; Reviewed; Region: PRK00159 1112204000061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1112204000062 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1112204000063 glutamine binding [chemical binding]; other site 1112204000064 catalytic triad [active] 1112204000065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204000066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204000067 active site 1112204000068 ATP binding site [chemical binding]; other site 1112204000069 substrate binding site [chemical binding]; other site 1112204000070 activation loop (A-loop); other site 1112204000071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1112204000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1112204000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1112204000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1112204000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1112204000076 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204000077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204000078 active site 1112204000079 ATP binding site [chemical binding]; other site 1112204000080 substrate binding site [chemical binding]; other site 1112204000081 activation loop (A-loop); other site 1112204000082 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1112204000083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1112204000084 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1112204000085 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1112204000086 Protein phosphatase 2C; Region: PP2C; pfam00481 1112204000087 active site 1112204000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1112204000089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1112204000090 phosphopeptide binding site; other site 1112204000091 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1112204000092 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1112204000093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1112204000094 phosphopeptide binding site; other site 1112204000095 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1112204000096 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1112204000097 active site 1112204000098 FMN binding site [chemical binding]; other site 1112204000099 substrate binding site [chemical binding]; other site 1112204000100 3Fe-4S cluster binding site [ion binding]; other site 1112204000101 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1112204000102 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1112204000103 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1112204000104 FAD binding pocket [chemical binding]; other site 1112204000105 FAD binding motif [chemical binding]; other site 1112204000106 phosphate binding motif [ion binding]; other site 1112204000107 NAD binding pocket [chemical binding]; other site 1112204000108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204000109 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204000110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204000111 Walker A/P-loop; other site 1112204000112 ATP binding site [chemical binding]; other site 1112204000113 Q-loop/lid; other site 1112204000114 ABC transporter signature motif; other site 1112204000115 Walker B; other site 1112204000116 D-loop; other site 1112204000117 H-loop/switch region; other site 1112204000118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204000119 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1112204000120 Walker A/P-loop; other site 1112204000121 ATP binding site [chemical binding]; other site 1112204000122 Q-loop/lid; other site 1112204000123 ABC transporter signature motif; other site 1112204000124 Walker B; other site 1112204000125 D-loop; other site 1112204000126 H-loop/switch region; other site 1112204000127 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 1112204000128 active site 1112204000129 catalytic site [active] 1112204000130 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1112204000131 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204000132 FAD binding pocket [chemical binding]; other site 1112204000133 FAD binding motif [chemical binding]; other site 1112204000134 phosphate binding motif [ion binding]; other site 1112204000135 beta-alpha-beta structure motif; other site 1112204000136 NAD binding pocket [chemical binding]; other site 1112204000137 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204000138 catalytic loop [active] 1112204000139 iron binding site [ion binding]; other site 1112204000140 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1112204000141 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1112204000142 putative di-iron ligands [ion binding]; other site 1112204000143 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1112204000144 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1112204000145 active site 1112204000146 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1112204000147 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1112204000148 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204000149 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1112204000150 FMN-binding pocket [chemical binding]; other site 1112204000151 flavin binding motif; other site 1112204000152 phosphate binding motif [ion binding]; other site 1112204000153 beta-alpha-beta structure motif; other site 1112204000154 NAD binding pocket [chemical binding]; other site 1112204000155 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204000156 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1112204000157 catalytic loop [active] 1112204000158 iron binding site [ion binding]; other site 1112204000159 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1112204000160 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204000161 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1112204000162 FMN-binding pocket [chemical binding]; other site 1112204000163 flavin binding motif; other site 1112204000164 phosphate binding motif [ion binding]; other site 1112204000165 beta-alpha-beta structure motif; other site 1112204000166 NAD binding pocket [chemical binding]; other site 1112204000167 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204000168 catalytic loop [active] 1112204000169 iron binding site [ion binding]; other site 1112204000170 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1112204000171 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1112204000172 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1112204000173 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1112204000174 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1112204000175 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1112204000176 active site 1112204000177 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1112204000178 domain_subunit interface; other site 1112204000179 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1112204000180 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1112204000181 active site 1112204000182 FMN binding site [chemical binding]; other site 1112204000183 substrate binding site [chemical binding]; other site 1112204000184 3Fe-4S cluster binding site [ion binding]; other site 1112204000185 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1112204000186 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1112204000187 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204000188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204000189 non-specific DNA binding site [nucleotide binding]; other site 1112204000190 salt bridge; other site 1112204000191 sequence-specific DNA binding site [nucleotide binding]; other site 1112204000192 Cupin domain; Region: Cupin_2; pfam07883 1112204000193 ERCC4 domain; Region: ERCC4; cl10594 1112204000194 Secretory lipase; Region: LIP; pfam03583 1112204000195 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204000196 active site 1112204000197 ATP binding site [chemical binding]; other site 1112204000198 substrate binding site [chemical binding]; other site 1112204000199 activation loop (A-loop); other site 1112204000200 breast cancer carboxy-terminal domain; Region: BRCT; smart00292 1112204000201 Dimer interface [polypeptide binding]; other site 1112204000202 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1112204000203 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1112204000204 putative sugar binding sites [chemical binding]; other site 1112204000205 Q-X-W motif; other site 1112204000206 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1112204000207 active site 1112204000208 catalytic residues [active] 1112204000209 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1112204000210 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1112204000211 FAD binding pocket [chemical binding]; other site 1112204000212 FAD binding motif [chemical binding]; other site 1112204000213 phosphate binding motif [ion binding]; other site 1112204000214 beta-alpha-beta structure motif; other site 1112204000215 NAD(p) ribose binding residues [chemical binding]; other site 1112204000216 NAD binding pocket [chemical binding]; other site 1112204000217 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1112204000218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204000219 catalytic loop [active] 1112204000220 iron binding site [ion binding]; other site 1112204000221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204000222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204000223 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1112204000224 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1112204000225 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1112204000226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204000227 NAD(P) binding site [chemical binding]; other site 1112204000228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204000229 active site 1112204000230 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1112204000231 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204000232 NAD(P) binding site [chemical binding]; other site 1112204000233 catalytic residues [active] 1112204000234 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204000235 Cytochrome P450; Region: p450; cl12078 1112204000236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204000237 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1112204000238 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204000239 acyl-activating enzyme (AAE) consensus motif; other site 1112204000240 acyl-activating enzyme (AAE) consensus motif; other site 1112204000241 putative AMP binding site [chemical binding]; other site 1112204000242 putative active site [active] 1112204000243 putative CoA binding site [chemical binding]; other site 1112204000244 Survival protein SurE; Region: SurE; cl00448 1112204000245 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1112204000246 Ecdysteroid kinase; Region: EcKinase; cl17738 1112204000247 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204000248 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1112204000249 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1112204000250 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204000251 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204000252 Ecdysteroid kinase; Region: EcKinase; cl17738 1112204000253 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204000254 catalytic core [active] 1112204000255 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1112204000256 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1112204000257 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204000258 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204000259 DNA binding residues [nucleotide binding] 1112204000260 dimerization interface [polypeptide binding]; other site 1112204000261 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1112204000262 acyl-CoA synthetase; Validated; Region: PRK06188 1112204000263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204000264 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204000265 acyl-activating enzyme (AAE) consensus motif; other site 1112204000266 putative AMP binding site [chemical binding]; other site 1112204000267 putative active site [active] 1112204000268 putative CoA binding site [chemical binding]; other site 1112204000269 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1112204000270 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1112204000271 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1112204000272 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 1112204000273 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1112204000274 carboxyltransferase (CT) interaction site; other site 1112204000275 biotinylation site [posttranslational modification]; other site 1112204000276 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1112204000277 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204000278 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204000279 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1112204000280 oxaloacetate decarboxylase; Provisional; Region: PRK12331 1112204000281 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1112204000282 active site 1112204000283 catalytic residues [active] 1112204000284 metal binding site [ion binding]; metal-binding site 1112204000285 DUF35 OB-fold domain; Region: DUF35; pfam01796 1112204000286 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1112204000287 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1112204000288 active site 1112204000289 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1112204000290 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 1112204000291 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1112204000292 putative hydrophobic ligand binding site [chemical binding]; other site 1112204000293 protein interface [polypeptide binding]; other site 1112204000294 gate; other site 1112204000295 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1112204000296 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1112204000297 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1112204000298 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1112204000299 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1112204000300 active site 1112204000301 purine riboside binding site [chemical binding]; other site 1112204000302 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204000303 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1112204000304 NAD(P) binding site [chemical binding]; other site 1112204000305 catalytic residues [active] 1112204000306 Protein of unknown function DUF72; Region: DUF72; pfam01904 1112204000307 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 1112204000308 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1112204000309 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204000310 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1112204000311 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1112204000312 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1112204000313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204000314 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 1112204000315 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1112204000316 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1112204000317 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1112204000318 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1112204000319 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 1112204000320 nickel binding site [ion binding]; other site 1112204000321 NifU-like domain; Region: NifU; cl00484 1112204000322 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1112204000323 iron-sulfur cluster [ion binding]; other site 1112204000324 [2Fe-2S] cluster binding site [ion binding]; other site 1112204000325 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1112204000326 Acylphosphatase; Region: Acylphosphatase; pfam00708 1112204000327 HypF finger; Region: zf-HYPF; pfam07503 1112204000328 HypF finger; Region: zf-HYPF; pfam07503 1112204000329 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1112204000330 HupF/HypC family; Region: HupF_HypC; pfam01455 1112204000331 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1112204000332 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1112204000333 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1112204000334 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1112204000335 dimerization interface [polypeptide binding]; other site 1112204000336 ATP binding site [chemical binding]; other site 1112204000337 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1112204000338 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1112204000339 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1112204000340 DinB superfamily; Region: DinB_2; pfam12867 1112204000341 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1112204000342 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1112204000343 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1112204000344 Fic family protein [Function unknown]; Region: COG3177 1112204000345 Fic/DOC family; Region: Fic; pfam02661 1112204000346 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1112204000347 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1112204000348 active site 1112204000349 homodimer interface [polypeptide binding]; other site 1112204000350 catalytic site [active] 1112204000351 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204000352 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1112204000353 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1112204000354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204000355 dimer interface [polypeptide binding]; other site 1112204000356 conserved gate region; other site 1112204000357 putative PBP binding loops; other site 1112204000358 ABC-ATPase subunit interface; other site 1112204000359 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1112204000360 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1112204000361 Walker A/P-loop; other site 1112204000362 ATP binding site [chemical binding]; other site 1112204000363 Q-loop/lid; other site 1112204000364 ABC transporter signature motif; other site 1112204000365 Walker B; other site 1112204000366 D-loop; other site 1112204000367 H-loop/switch region; other site 1112204000368 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1112204000369 proline/glycine betaine transporter; Provisional; Region: PRK10642 1112204000370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204000371 putative substrate translocation pore; other site 1112204000372 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204000373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204000374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204000375 putative substrate translocation pore; other site 1112204000376 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1112204000377 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204000378 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204000379 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204000380 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1112204000381 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1112204000382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1112204000383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204000384 dimer interface [polypeptide binding]; other site 1112204000385 conserved gate region; other site 1112204000386 putative PBP binding loops; other site 1112204000387 ABC-ATPase subunit interface; other site 1112204000388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1112204000389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1112204000390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204000391 dimer interface [polypeptide binding]; other site 1112204000392 conserved gate region; other site 1112204000393 putative PBP binding loops; other site 1112204000394 ABC-ATPase subunit interface; other site 1112204000395 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1112204000396 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204000397 Walker A/P-loop; other site 1112204000398 ATP binding site [chemical binding]; other site 1112204000399 Q-loop/lid; other site 1112204000400 ABC transporter signature motif; other site 1112204000401 Walker B; other site 1112204000402 D-loop; other site 1112204000403 H-loop/switch region; other site 1112204000404 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1112204000405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204000406 Walker A/P-loop; other site 1112204000407 ATP binding site [chemical binding]; other site 1112204000408 Q-loop/lid; other site 1112204000409 ABC transporter signature motif; other site 1112204000410 Walker B; other site 1112204000411 D-loop; other site 1112204000412 H-loop/switch region; other site 1112204000413 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1112204000414 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1112204000415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204000416 active site 1112204000417 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1112204000418 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1112204000419 active site 1112204000420 non-prolyl cis peptide bond; other site 1112204000421 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1112204000422 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204000423 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204000424 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1112204000425 active site 1112204000426 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1112204000427 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1112204000428 active site 1112204000429 catalytic tetrad [active] 1112204000430 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1112204000431 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1112204000432 active site 1112204000433 catalytic tetrad [active] 1112204000434 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1112204000435 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204000436 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1112204000437 active site 1112204000438 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1112204000439 non-prolyl cis peptide bond; other site 1112204000440 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1112204000441 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1112204000442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204000443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204000444 DNA binding residues [nucleotide binding] 1112204000445 dimerization interface [polypeptide binding]; other site 1112204000446 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1112204000447 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1112204000448 dimer interface [polypeptide binding]; other site 1112204000449 acyl-activating enzyme (AAE) consensus motif; other site 1112204000450 putative active site [active] 1112204000451 AMP binding site [chemical binding]; other site 1112204000452 putative CoA binding site [chemical binding]; other site 1112204000453 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1112204000454 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1112204000455 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204000456 ATP binding site [chemical binding]; other site 1112204000457 putative Mg++ binding site [ion binding]; other site 1112204000458 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204000459 nucleotide binding region [chemical binding]; other site 1112204000460 ATP-binding site [chemical binding]; other site 1112204000461 Isochorismatase family; Region: Isochorismatase; pfam00857 1112204000462 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1112204000463 catalytic triad [active] 1112204000464 conserved cis-peptide bond; other site 1112204000465 Secretory lipase; Region: LIP; pfam03583 1112204000466 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204000467 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1112204000468 active site 1112204000469 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1112204000470 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 1112204000471 putative uracil binding site [chemical binding]; other site 1112204000472 putative active site [active] 1112204000473 SIR2-like domain; Region: SIR2_2; pfam13289 1112204000474 PLD-like domain; Region: PLDc_2; pfam13091 1112204000475 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1112204000476 putative active site [active] 1112204000477 catalytic site [active] 1112204000478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1112204000479 Superfamily II helicase [General function prediction only]; Region: COG1204 1112204000480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204000481 ATP binding site [chemical binding]; other site 1112204000482 ATP binding site [chemical binding]; other site 1112204000483 putative Mg++ binding site [ion binding]; other site 1112204000484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204000485 nucleotide binding region [chemical binding]; other site 1112204000486 ATP-binding site [chemical binding]; other site 1112204000487 Z1 domain; Region: Z1; pfam10593 1112204000488 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1112204000489 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1112204000490 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1112204000491 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1112204000492 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1112204000493 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1112204000494 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1112204000495 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1112204000496 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1112204000497 substrate interaction site [chemical binding]; other site 1112204000498 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1112204000499 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1112204000500 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1112204000501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1112204000502 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1112204000503 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204000504 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204000505 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204000506 active site 1112204000507 ATP binding site [chemical binding]; other site 1112204000508 substrate binding site [chemical binding]; other site 1112204000509 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1112204000510 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204000511 MULE transposase domain; Region: MULE; pfam10551 1112204000512 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1112204000513 AAA domain; Region: AAA_12; pfam13087 1112204000514 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1112204000515 putative active site [active] 1112204000516 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1112204000517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204000518 ATP binding site [chemical binding]; other site 1112204000519 putative Mg++ binding site [ion binding]; other site 1112204000520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204000521 nucleotide binding region [chemical binding]; other site 1112204000522 ATP-binding site [chemical binding]; other site 1112204000523 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1112204000524 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1112204000525 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1112204000526 Protein of unknown function DUF262; Region: DUF262; pfam03235 1112204000527 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1112204000528 Nuclease-related domain; Region: NERD; pfam08378 1112204000529 Part of AAA domain; Region: AAA_19; pfam13245 1112204000530 Family description; Region: UvrD_C_2; pfam13538 1112204000531 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1112204000532 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1112204000533 Helix-turn-helix domain; Region: HTH_38; pfam13936 1112204000534 Integrase core domain; Region: rve; pfam00665 1112204000535 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1112204000536 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1112204000537 minor groove reading motif; other site 1112204000538 helix-hairpin-helix signature motif; other site 1112204000539 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1112204000540 hydrophobic ligand binding site; other site 1112204000541 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1112204000542 SWIM zinc finger; Region: SWIM; pfam04434 1112204000543 MoxR-like ATPases [General function prediction only]; Region: COG0714 1112204000544 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1112204000545 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1112204000546 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1112204000547 metal ion-dependent adhesion site (MIDAS); other site 1112204000548 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1112204000549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204000550 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1112204000551 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1112204000552 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1112204000553 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1112204000554 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204000555 classical (c) SDRs; Region: SDR_c; cd05233 1112204000556 NAD(P) binding site [chemical binding]; other site 1112204000557 active site 1112204000558 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1112204000559 classical (c) SDRs; Region: SDR_c; cd05233 1112204000560 NAD(P) binding site [chemical binding]; other site 1112204000561 active site 1112204000562 benzoate transport; Region: 2A0115; TIGR00895 1112204000563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204000564 putative substrate translocation pore; other site 1112204000565 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1112204000566 active site 1112204000567 catalytic site [active] 1112204000568 Zn binding site [ion binding]; other site 1112204000569 tetramer interface [polypeptide binding]; other site 1112204000570 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1112204000571 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1112204000572 active site 1112204000573 homodimer interface [polypeptide binding]; other site 1112204000574 homotetramer interface [polypeptide binding]; other site 1112204000575 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1112204000576 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1112204000577 DNA binding site [nucleotide binding] 1112204000578 domain linker motif; other site 1112204000579 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1112204000580 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1112204000581 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1112204000582 active site 1112204000583 catalytic site [active] 1112204000584 substrate binding site [chemical binding]; other site 1112204000585 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1112204000586 Dimer interface [polypeptide binding]; other site 1112204000587 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1112204000588 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1112204000589 putative metal binding site [ion binding]; other site 1112204000590 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1112204000591 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204000592 EthD domain; Region: EthD; cl17553 1112204000593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1112204000594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204000595 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1112204000596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204000597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204000598 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1112204000599 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204000600 catalytic loop [active] 1112204000601 iron binding site [ion binding]; other site 1112204000602 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204000603 Cytochrome P450; Region: p450; cl12078 1112204000604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204000605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204000606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204000607 dimerization interface [polypeptide binding]; other site 1112204000608 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1112204000609 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1112204000610 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1112204000611 metal ion-dependent adhesion site (MIDAS); other site 1112204000612 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1112204000613 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1112204000614 PE-PPE domain; Region: PE-PPE; pfam08237 1112204000615 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1112204000616 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204000617 acyl-activating enzyme (AAE) consensus motif; other site 1112204000618 AMP binding site [chemical binding]; other site 1112204000619 active site 1112204000620 CoA binding site [chemical binding]; other site 1112204000621 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204000622 Cytochrome P450; Region: p450; cl12078 1112204000623 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204000624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204000625 alanine racemase; Reviewed; Region: PRK13340 1112204000626 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1112204000627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1112204000628 DNA binding site [nucleotide binding] 1112204000629 domain linker motif; other site 1112204000630 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1112204000631 ligand binding site [chemical binding]; other site 1112204000632 dimerization interface [polypeptide binding]; other site 1112204000633 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1112204000634 N- and C-terminal domain interface [polypeptide binding]; other site 1112204000635 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1112204000636 active site 1112204000637 putative catalytic site [active] 1112204000638 metal binding site [ion binding]; metal-binding site 1112204000639 ATP binding site [chemical binding]; other site 1112204000640 carbohydrate binding site [chemical binding]; other site 1112204000641 short chain dehydrogenase; Validated; Region: PRK08324 1112204000642 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1112204000643 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1112204000644 putative NAD(P) binding site [chemical binding]; other site 1112204000645 active site 1112204000646 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1112204000647 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 1112204000648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204000649 putative substrate translocation pore; other site 1112204000650 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1112204000651 Transcription factor WhiB; Region: Whib; pfam02467 1112204000652 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1112204000653 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204000654 active site 1112204000655 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204000656 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204000657 active site 1112204000658 ATP binding site [chemical binding]; other site 1112204000659 substrate binding site [chemical binding]; other site 1112204000660 activation loop (A-loop); other site 1112204000661 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1112204000662 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1112204000663 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204000664 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204000665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204000666 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1112204000667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204000668 DNA-binding site [nucleotide binding]; DNA binding site 1112204000669 UTRA domain; Region: UTRA; pfam07702 1112204000670 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1112204000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204000672 putative substrate translocation pore; other site 1112204000673 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1112204000674 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1112204000675 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1112204000676 dimer interface [polypeptide binding]; other site 1112204000677 active site 1112204000678 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1112204000679 dimer interface [polypeptide binding]; other site 1112204000680 active site 1112204000681 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1112204000682 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1112204000683 active site 1112204000684 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1112204000685 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1112204000686 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204000687 acyl-activating enzyme (AAE) consensus motif; other site 1112204000688 AMP binding site [chemical binding]; other site 1112204000689 active site 1112204000690 CoA binding site [chemical binding]; other site 1112204000691 GAF domain; Region: GAF; pfam01590 1112204000692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204000693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204000694 DNA binding residues [nucleotide binding] 1112204000695 dimerization interface [polypeptide binding]; other site 1112204000696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1112204000697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204000698 Coenzyme A binding pocket [chemical binding]; other site 1112204000699 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204000700 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204000701 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204000702 hypothetical protein; Provisional; Region: PRK07236 1112204000703 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1112204000704 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1112204000705 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204000706 NAD binding site [chemical binding]; other site 1112204000707 catalytic residues [active] 1112204000708 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1112204000709 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1112204000710 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1112204000711 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1112204000712 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204000713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204000714 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1112204000715 Beta-lactamase; Region: Beta-lactamase; pfam00144 1112204000716 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1112204000717 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1112204000718 tetramer interface [polypeptide binding]; other site 1112204000719 catalytic Zn binding site [ion binding]; other site 1112204000720 NADP binding site [chemical binding]; other site 1112204000721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204000722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204000723 DNA binding residues [nucleotide binding] 1112204000724 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1112204000725 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1112204000726 NAD binding site [chemical binding]; other site 1112204000727 catalytic Zn binding site [ion binding]; other site 1112204000728 substrate binding site [chemical binding]; other site 1112204000729 structural Zn binding site [ion binding]; other site 1112204000730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1112204000731 Predicted membrane protein [Function unknown]; Region: COG2259 1112204000732 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204000733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204000734 putative DNA binding site [nucleotide binding]; other site 1112204000735 putative Zn2+ binding site [ion binding]; other site 1112204000736 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204000737 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1112204000738 TrkA-N domain; Region: TrkA_N; pfam02254 1112204000739 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1112204000740 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1112204000741 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1112204000742 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1112204000743 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1112204000744 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1112204000745 putative active site [active] 1112204000746 putative substrate binding site [chemical binding]; other site 1112204000747 putative cosubstrate binding site; other site 1112204000748 catalytic site [active] 1112204000749 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1112204000750 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1112204000751 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1112204000752 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1112204000753 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 1112204000754 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1112204000755 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1112204000756 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204000757 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1112204000758 FAD binding pocket [chemical binding]; other site 1112204000759 FAD binding motif [chemical binding]; other site 1112204000760 phosphate binding motif [ion binding]; other site 1112204000761 beta-alpha-beta structure motif; other site 1112204000762 NAD binding pocket [chemical binding]; other site 1112204000763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204000764 catalytic loop [active] 1112204000765 iron binding site [ion binding]; other site 1112204000766 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1112204000767 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1112204000768 [2Fe-2S] cluster binding site [ion binding]; other site 1112204000769 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1112204000770 putative alpha subunit interface [polypeptide binding]; other site 1112204000771 putative active site [active] 1112204000772 putative substrate binding site [chemical binding]; other site 1112204000773 Fe binding site [ion binding]; other site 1112204000774 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1112204000775 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1112204000776 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1112204000777 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1112204000778 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1112204000779 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1112204000780 active site 1112204000781 DNA binding site [nucleotide binding] 1112204000782 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1112204000783 DNA binding site [nucleotide binding] 1112204000784 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204000785 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204000786 active site 1112204000787 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1112204000788 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1112204000789 ligand binding site [chemical binding]; other site 1112204000790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1112204000791 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1112204000792 metal binding triad; other site 1112204000793 choline dehydrogenase; Validated; Region: PRK02106 1112204000794 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1112204000795 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1112204000796 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1112204000797 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204000798 tetramerization interface [polypeptide binding]; other site 1112204000799 NAD(P) binding site [chemical binding]; other site 1112204000800 catalytic residues [active] 1112204000801 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1112204000802 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1112204000803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204000804 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204000805 DNA binding residues [nucleotide binding] 1112204000806 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1112204000807 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1112204000808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204000809 S-adenosylmethionine binding site [chemical binding]; other site 1112204000810 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1112204000811 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1112204000812 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204000813 hypothetical protein; Provisional; Region: PRK11770 1112204000814 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1112204000815 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1112204000816 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1112204000817 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1112204000818 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204000819 NAD(P) binding site [chemical binding]; other site 1112204000820 catalytic residues [active] 1112204000821 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1112204000822 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1112204000823 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204000824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204000825 putative DNA binding site [nucleotide binding]; other site 1112204000826 putative Zn2+ binding site [ion binding]; other site 1112204000827 AsnC family; Region: AsnC_trans_reg; pfam01037 1112204000828 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1112204000829 TPP-binding site [chemical binding]; other site 1112204000830 PYR/PP interface [polypeptide binding]; other site 1112204000831 dimer interface [polypeptide binding]; other site 1112204000832 TPP binding site [chemical binding]; other site 1112204000833 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1112204000834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204000835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204000836 putative substrate translocation pore; other site 1112204000837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204000838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204000839 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1112204000840 putative dimerization interface [polypeptide binding]; other site 1112204000841 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1112204000842 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1112204000843 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1112204000844 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1112204000845 Predicted membrane protein [Function unknown]; Region: COG4325 1112204000846 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1112204000847 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204000848 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1112204000849 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1112204000850 active site 1112204000851 dimer interface [polypeptide binding]; other site 1112204000852 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1112204000853 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1112204000854 active site 1112204000855 FMN binding site [chemical binding]; other site 1112204000856 substrate binding site [chemical binding]; other site 1112204000857 3Fe-4S cluster binding site [ion binding]; other site 1112204000858 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1112204000859 domain interface; other site 1112204000860 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1112204000861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204000862 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 1112204000863 putative hydrophobic ligand binding site [chemical binding]; other site 1112204000864 Cutinase; Region: Cutinase; pfam01083 1112204000865 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1112204000866 RNA binding surface [nucleotide binding]; other site 1112204000867 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1112204000868 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1112204000869 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1112204000870 dimer interface [polypeptide binding]; other site 1112204000871 putative anticodon binding site; other site 1112204000872 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1112204000873 motif 1; other site 1112204000874 dimer interface [polypeptide binding]; other site 1112204000875 active site 1112204000876 motif 2; other site 1112204000877 motif 3; other site 1112204000878 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1112204000879 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1112204000880 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1112204000881 NAD(P) binding site [chemical binding]; other site 1112204000882 catalytic residues [active] 1112204000883 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1112204000884 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1112204000885 putative active site [active] 1112204000886 putative metal binding site [ion binding]; other site 1112204000887 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1112204000888 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1112204000889 Helix-turn-helix domain; Region: HTH_18; pfam12833 1112204000890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204000891 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204000892 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204000893 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1112204000894 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1112204000895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204000896 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1112204000897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204000898 NAD(P) binding site [chemical binding]; other site 1112204000899 active site 1112204000900 Predicted membrane protein [Function unknown]; Region: COG2119 1112204000901 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1112204000902 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1112204000903 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1112204000904 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1112204000905 Walker A/P-loop; other site 1112204000906 ATP binding site [chemical binding]; other site 1112204000907 Q-loop/lid; other site 1112204000908 ABC transporter signature motif; other site 1112204000909 Walker B; other site 1112204000910 D-loop; other site 1112204000911 H-loop/switch region; other site 1112204000912 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1112204000913 Walker A/P-loop; other site 1112204000914 ATP binding site [chemical binding]; other site 1112204000915 Q-loop/lid; other site 1112204000916 ABC transporter signature motif; other site 1112204000917 Walker B; other site 1112204000918 D-loop; other site 1112204000919 H-loop/switch region; other site 1112204000920 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1112204000921 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1112204000922 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1112204000923 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1112204000924 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1112204000925 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1112204000926 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1112204000927 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1112204000928 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1112204000929 tandem repeat interface [polypeptide binding]; other site 1112204000930 oligomer interface [polypeptide binding]; other site 1112204000931 active site residues [active] 1112204000932 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1112204000933 active site residue [active] 1112204000934 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1112204000935 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1112204000936 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1112204000937 putative active site [active] 1112204000938 catalytic site [active] 1112204000939 putative metal binding site [ion binding]; other site 1112204000940 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1112204000941 Ferritin-like domain; Region: Ferritin; pfam00210 1112204000942 ferroxidase diiron center [ion binding]; other site 1112204000943 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1112204000944 CAAX protease self-immunity; Region: Abi; pfam02517 1112204000945 RNA binding site [nucleotide binding]; other site 1112204000946 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1112204000947 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1112204000948 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1112204000949 Predicted transcriptional regulators [Transcription]; Region: COG1733 1112204000950 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1112204000951 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1112204000952 Cupin domain; Region: Cupin_2; cl17218 1112204000953 Homeodomain-like domain; Region: HTH_23; pfam13384 1112204000954 Winged helix-turn helix; Region: HTH_29; pfam13551 1112204000955 Homeodomain-like domain; Region: HTH_32; pfam13565 1112204000956 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1112204000957 Predicted transcriptional regulators [Transcription]; Region: COG1733 1112204000958 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1112204000959 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1112204000960 prephenate dehydratase; Provisional; Region: PRK11898 1112204000961 Prephenate dehydratase; Region: PDT; pfam00800 1112204000962 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1112204000963 putative L-Phe binding site [chemical binding]; other site 1112204000964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204000965 catalytic core [active] 1112204000966 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1112204000967 Septum formation; Region: Septum_form; pfam13845 1112204000968 Septum formation; Region: Septum_form; pfam13845 1112204000969 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1112204000970 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1112204000971 seryl-tRNA synthetase; Provisional; Region: PRK05431 1112204000972 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1112204000973 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1112204000974 dimer interface [polypeptide binding]; other site 1112204000975 active site 1112204000976 motif 1; other site 1112204000977 motif 2; other site 1112204000978 motif 3; other site 1112204000979 Secretory lipase; Region: LIP; pfam03583 1112204000980 Cupin; Region: Cupin_6; pfam12852 1112204000981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204000982 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1112204000983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204000984 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1112204000985 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1112204000986 putative NAD(P) binding site [chemical binding]; other site 1112204000987 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204000988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204000989 active site 1112204000990 phosphorylation site [posttranslational modification] 1112204000991 intermolecular recognition site; other site 1112204000992 dimerization interface [polypeptide binding]; other site 1112204000993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204000994 DNA binding residues [nucleotide binding] 1112204000995 dimerization interface [polypeptide binding]; other site 1112204000996 Histidine kinase; Region: HisKA_3; pfam07730 1112204000997 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1112204000998 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204000999 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001000 active site 1112204001001 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1112204001002 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1112204001003 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1112204001004 iron-sulfur cluster [ion binding]; other site 1112204001005 [2Fe-2S] cluster binding site [ion binding]; other site 1112204001006 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1112204001007 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1112204001008 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1112204001009 putative acyl-acceptor binding pocket; other site 1112204001010 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204001011 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1112204001012 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1112204001013 active site 1112204001014 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1112204001015 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1112204001016 DNA binding site [nucleotide binding] 1112204001017 domain linker motif; other site 1112204001018 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1112204001019 ligand binding site [chemical binding]; other site 1112204001020 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1112204001021 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1112204001022 putative acyl-acceptor binding pocket; other site 1112204001023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204001024 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1112204001025 active site 1112204001026 motif I; other site 1112204001027 motif II; other site 1112204001028 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1112204001029 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1112204001030 amidase catalytic site [active] 1112204001031 Zn binding residues [ion binding]; other site 1112204001032 substrate binding site [chemical binding]; other site 1112204001033 Stage II sporulation protein; Region: SpoIID; pfam08486 1112204001034 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1112204001035 LGFP repeat; Region: LGFP; pfam08310 1112204001036 GAF domain; Region: GAF; pfam01590 1112204001037 ANTAR domain; Region: ANTAR; pfam03861 1112204001038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1112204001039 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1112204001040 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204001041 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1112204001042 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1112204001043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204001044 UDP-galactopyranose mutase; Region: GLF; pfam03275 1112204001045 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1112204001046 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1112204001047 active site 1112204001048 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1112204001049 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1112204001050 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1112204001051 UbiA prenyltransferase family; Region: UbiA; pfam01040 1112204001052 Putative esterase; Region: Esterase; pfam00756 1112204001053 Putative esterase; Region: Esterase; pfam00756 1112204001054 Cutinase; Region: Cutinase; pfam01083 1112204001055 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1112204001056 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204001057 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1112204001058 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1112204001059 acyl-activating enzyme (AAE) consensus motif; other site 1112204001060 active site 1112204001061 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1112204001062 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1112204001063 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1112204001064 active site 1112204001065 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1112204001066 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1112204001067 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1112204001068 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1112204001069 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1112204001070 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1112204001071 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1112204001072 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 1112204001073 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1112204001074 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1112204001075 dimerization interface [polypeptide binding]; other site 1112204001076 DPS ferroxidase diiron center [ion binding]; other site 1112204001077 ion pore; other site 1112204001078 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1112204001079 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1112204001080 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1112204001081 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1112204001082 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204001083 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001084 active site 1112204001085 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1112204001086 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1112204001087 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1112204001088 active site 1112204001089 trimer interface [polypeptide binding]; other site 1112204001090 dimer interface [polypeptide binding]; other site 1112204001091 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1112204001092 hydrophobic ligand binding site; other site 1112204001093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204001094 dimerization interface [polypeptide binding]; other site 1112204001095 putative DNA binding site [nucleotide binding]; other site 1112204001096 putative Zn2+ binding site [ion binding]; other site 1112204001097 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1112204001098 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1112204001099 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1112204001100 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1112204001101 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204001102 DNA binding residues [nucleotide binding] 1112204001103 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1112204001104 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1112204001105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204001106 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1112204001107 putative substrate translocation pore; other site 1112204001108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204001109 short chain dehydrogenase; Provisional; Region: PRK08251 1112204001110 NAD(P) binding site [chemical binding]; other site 1112204001111 active site 1112204001112 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204001113 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1112204001114 Baculoviridae p74 conserved region; Region: Baculo_p74; pfam04583 1112204001115 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1112204001116 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1112204001117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204001118 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204001119 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1112204001120 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1112204001121 active site 1112204001122 catalytic tetrad [active] 1112204001123 Predicted membrane protein [Function unknown]; Region: COG2246 1112204001124 GtrA-like protein; Region: GtrA; pfam04138 1112204001125 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1112204001126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204001127 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1112204001128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1112204001129 active site 1112204001130 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1112204001131 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204001132 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1112204001133 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001134 active site 1112204001135 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204001136 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1112204001137 catalytic site [active] 1112204001138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204001139 MarR family; Region: MarR_2; cl17246 1112204001140 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1112204001141 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204001142 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1112204001143 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1112204001144 active site 1112204001145 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1112204001146 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1112204001147 Walker A/P-loop; other site 1112204001148 ATP binding site [chemical binding]; other site 1112204001149 Q-loop/lid; other site 1112204001150 ABC transporter signature motif; other site 1112204001151 Walker B; other site 1112204001152 D-loop; other site 1112204001153 H-loop/switch region; other site 1112204001154 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1112204001155 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1112204001156 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1112204001157 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1112204001158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204001159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204001160 catalytic residue [active] 1112204001161 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204001162 MarR family; Region: MarR; pfam01047 1112204001163 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1112204001164 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1112204001165 NAD(P) binding site [chemical binding]; other site 1112204001166 Predicted membrane protein [Function unknown]; Region: COG3619 1112204001167 short chain dehydrogenase; Provisional; Region: PRK05854 1112204001168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204001169 NAD(P) binding site [chemical binding]; other site 1112204001170 active site 1112204001171 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1112204001172 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1112204001173 MarR family; Region: MarR; pfam01047 1112204001174 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1112204001175 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1112204001176 Citrate synthase; Region: Citrate_synt; pfam00285 1112204001177 oxalacetate binding site [chemical binding]; other site 1112204001178 citrylCoA binding site [chemical binding]; other site 1112204001179 coenzyme A binding site [chemical binding]; other site 1112204001180 catalytic triad [active] 1112204001181 Helix-turn-helix domain; Region: HTH_17; pfam12728 1112204001182 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1112204001183 Citrate synthase; Region: Citrate_synt; pfam00285 1112204001184 oxalacetate binding site [chemical binding]; other site 1112204001185 citrylCoA binding site [chemical binding]; other site 1112204001186 coenzyme A binding site [chemical binding]; other site 1112204001187 catalytic triad [active] 1112204001188 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1112204001189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204001190 S-adenosylmethionine binding site [chemical binding]; other site 1112204001191 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1112204001192 RNA/DNA hybrid binding site [nucleotide binding]; other site 1112204001193 active site 1112204001194 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1112204001195 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1112204001196 putative ligand binding site [chemical binding]; other site 1112204001197 putative NAD binding site [chemical binding]; other site 1112204001198 catalytic site [active] 1112204001199 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1112204001200 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1112204001201 DNA binding residues [nucleotide binding] 1112204001202 putative dimer interface [polypeptide binding]; other site 1112204001203 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1112204001204 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1112204001205 active site 1112204001206 catalytic tetrad [active] 1112204001207 short chain dehydrogenase; Provisional; Region: PRK07814 1112204001208 classical (c) SDRs; Region: SDR_c; cd05233 1112204001209 NAD(P) binding site [chemical binding]; other site 1112204001210 active site 1112204001211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1112204001212 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1112204001213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204001214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204001215 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1112204001216 Walker A/P-loop; other site 1112204001217 ATP binding site [chemical binding]; other site 1112204001218 Q-loop/lid; other site 1112204001219 ABC transporter signature motif; other site 1112204001220 Walker B; other site 1112204001221 D-loop; other site 1112204001222 H-loop/switch region; other site 1112204001223 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204001224 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204001225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204001226 Walker A/P-loop; other site 1112204001227 ATP binding site [chemical binding]; other site 1112204001228 Q-loop/lid; other site 1112204001229 ABC transporter signature motif; other site 1112204001230 Walker B; other site 1112204001231 D-loop; other site 1112204001232 H-loop/switch region; other site 1112204001233 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204001234 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204001235 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204001236 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204001237 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204001238 tyramine oxidase; Provisional; Region: tynA; PRK11504 1112204001239 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1112204001240 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1112204001241 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1112204001242 TROVE domain; Region: TROVE; pfam05731 1112204001243 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204001244 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204001245 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204001246 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001247 active site 1112204001248 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1112204001249 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1112204001250 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1112204001251 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1112204001252 Putative esterase; Region: Esterase; pfam00756 1112204001253 S-formylglutathione hydrolase; Region: PLN02442 1112204001254 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1112204001255 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1112204001256 ABC1 family; Region: ABC1; cl17513 1112204001257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204001258 dimerization interface [polypeptide binding]; other site 1112204001259 putative DNA binding site [nucleotide binding]; other site 1112204001260 putative Zn2+ binding site [ion binding]; other site 1112204001261 H+ Antiporter protein; Region: 2A0121; TIGR00900 1112204001262 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1112204001263 putative homodimer interface [polypeptide binding]; other site 1112204001264 putative homotetramer interface [polypeptide binding]; other site 1112204001265 putative allosteric switch controlling residues; other site 1112204001266 putative metal binding site [ion binding]; other site 1112204001267 putative homodimer-homodimer interface [polypeptide binding]; other site 1112204001268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1112204001269 metal-binding site [ion binding] 1112204001270 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1112204001271 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1112204001272 metal-binding site [ion binding] 1112204001273 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1112204001274 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1112204001275 benzoate transport; Region: 2A0115; TIGR00895 1112204001276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204001277 putative substrate translocation pore; other site 1112204001278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204001279 putative substrate translocation pore; other site 1112204001280 Putative esterase; Region: Esterase; pfam00756 1112204001281 hypothetical protein; Validated; Region: PRK07121 1112204001282 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1112204001283 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1112204001284 Moco binding site; other site 1112204001285 metal coordination site [ion binding]; other site 1112204001286 Cutinase; Region: Cutinase; pfam01083 1112204001287 PE-PPE domain; Region: PE-PPE; pfam08237 1112204001288 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1112204001289 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1112204001290 ligand binding site [chemical binding]; other site 1112204001291 homodimer interface [polypeptide binding]; other site 1112204001292 NAD(P) binding site [chemical binding]; other site 1112204001293 trimer interface B [polypeptide binding]; other site 1112204001294 trimer interface A [polypeptide binding]; other site 1112204001295 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1112204001296 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1112204001297 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1112204001298 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1112204001299 putative active site [active] 1112204001300 DoxX-like family; Region: DoxX_2; pfam13564 1112204001301 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1112204001302 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1112204001303 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1112204001304 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1112204001305 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1112204001306 active site clefts [active] 1112204001307 zinc binding site [ion binding]; other site 1112204001308 dimer interface [polypeptide binding]; other site 1112204001309 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1112204001310 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1112204001311 active site 1112204001312 metal binding site [ion binding]; metal-binding site 1112204001313 hexamer interface [polypeptide binding]; other site 1112204001314 classical (c) SDRs; Region: SDR_c; cd05233 1112204001315 short chain dehydrogenase; Provisional; Region: PRK05650 1112204001316 NAD(P) binding site [chemical binding]; other site 1112204001317 active site 1112204001318 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1112204001319 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1112204001320 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1112204001321 nucleotide binding site [chemical binding]; other site 1112204001322 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1112204001323 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1112204001324 active site 1112204001325 DNA binding site [nucleotide binding] 1112204001326 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1112204001327 DNA binding site [nucleotide binding] 1112204001328 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1112204001329 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1112204001330 putative DNA binding site [nucleotide binding]; other site 1112204001331 putative homodimer interface [polypeptide binding]; other site 1112204001332 H+ Antiporter protein; Region: 2A0121; TIGR00900 1112204001333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204001334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204001335 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1112204001336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204001337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204001338 dimerization interface [polypeptide binding]; other site 1112204001339 LysE type translocator; Region: LysE; cl00565 1112204001340 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1112204001341 oligomeric interface; other site 1112204001342 putative active site [active] 1112204001343 homodimer interface [polypeptide binding]; other site 1112204001344 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204001345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204001346 active site 1112204001347 phosphorylation site [posttranslational modification] 1112204001348 intermolecular recognition site; other site 1112204001349 dimerization interface [polypeptide binding]; other site 1112204001350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204001351 DNA binding residues [nucleotide binding] 1112204001352 dimerization interface [polypeptide binding]; other site 1112204001353 Histidine kinase; Region: HisKA_3; pfam07730 1112204001354 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 1112204001355 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1112204001356 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1112204001357 putative active site [active] 1112204001358 putative substrate binding site [chemical binding]; other site 1112204001359 putative FMN binding site [chemical binding]; other site 1112204001360 putative catalytic residues [active] 1112204001361 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204001362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001366 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204001367 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204001368 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1112204001369 active site 1112204001370 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1112204001371 putative active site [active] 1112204001372 putative substrate binding site [chemical binding]; other site 1112204001373 ATP binding site [chemical binding]; other site 1112204001374 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204001375 catalytic core [active] 1112204001376 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1112204001377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1112204001378 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1112204001379 metal binding site [ion binding]; metal-binding site 1112204001380 active site 1112204001381 I-site; other site 1112204001382 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1112204001383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204001384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204001385 DNA binding residues [nucleotide binding] 1112204001386 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1112204001387 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1112204001388 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204001389 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1112204001390 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204001391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204001392 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1112204001393 Walker A/P-loop; other site 1112204001394 ATP binding site [chemical binding]; other site 1112204001395 Q-loop/lid; other site 1112204001396 ABC transporter signature motif; other site 1112204001397 Walker B; other site 1112204001398 D-loop; other site 1112204001399 H-loop/switch region; other site 1112204001400 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1112204001401 DNA binding residues [nucleotide binding] 1112204001402 TOBE domain; Region: TOBE; cl01440 1112204001403 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1112204001404 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1112204001405 sulfate transport protein; Provisional; Region: cysT; CHL00187 1112204001406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204001407 putative PBP binding loops; other site 1112204001408 ABC-ATPase subunit interface; other site 1112204001409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204001410 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1112204001411 Walker A/P-loop; other site 1112204001412 ATP binding site [chemical binding]; other site 1112204001413 Q-loop/lid; other site 1112204001414 ABC transporter signature motif; other site 1112204001415 Walker B; other site 1112204001416 D-loop; other site 1112204001417 H-loop/switch region; other site 1112204001418 TOBE domain; Region: TOBE; pfam03459 1112204001419 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1112204001420 cyclase homology domain; Region: CHD; cd07302 1112204001421 nucleotidyl binding site; other site 1112204001422 metal binding site [ion binding]; metal-binding site 1112204001423 dimer interface [polypeptide binding]; other site 1112204001424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001428 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1112204001429 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204001430 dimer interface [polypeptide binding]; other site 1112204001431 active site 1112204001432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204001433 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1112204001434 substrate binding site [chemical binding]; other site 1112204001435 oxyanion hole (OAH) forming residues; other site 1112204001436 trimer interface [polypeptide binding]; other site 1112204001437 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1112204001438 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1112204001439 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1112204001440 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1112204001441 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204001442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204001443 active site 1112204001444 phosphorylation site [posttranslational modification] 1112204001445 intermolecular recognition site; other site 1112204001446 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204001447 DNA binding residues [nucleotide binding] 1112204001448 dimerization interface [polypeptide binding]; other site 1112204001449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1112204001450 Histidine kinase; Region: HisKA_3; pfam07730 1112204001451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204001452 ATP binding site [chemical binding]; other site 1112204001453 Mg2+ binding site [ion binding]; other site 1112204001454 G-X-G motif; other site 1112204001455 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1112204001456 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1112204001457 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1112204001458 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1112204001459 Walker A/P-loop; other site 1112204001460 ATP binding site [chemical binding]; other site 1112204001461 Q-loop/lid; other site 1112204001462 ABC transporter signature motif; other site 1112204001463 Walker B; other site 1112204001464 D-loop; other site 1112204001465 H-loop/switch region; other site 1112204001466 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1112204001467 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1112204001468 active site 1112204001469 diiron metal binding site [ion binding]; other site 1112204001470 MMPL family; Region: MMPL; pfam03176 1112204001471 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1112204001472 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1112204001473 NAD binding site [chemical binding]; other site 1112204001474 catalytic Zn binding site [ion binding]; other site 1112204001475 substrate binding site [chemical binding]; other site 1112204001476 structural Zn binding site [ion binding]; other site 1112204001477 Ion channel; Region: Ion_trans_2; pfam07885 1112204001478 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1112204001479 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1112204001480 active site 1112204001481 Zn binding site [ion binding]; other site 1112204001482 Pirin; Region: Pirin; pfam02678 1112204001483 Pirin-related protein [General function prediction only]; Region: COG1741 1112204001484 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1112204001485 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1112204001486 Predicted integral membrane protein [Function unknown]; Region: COG0392 1112204001487 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1112204001488 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1112204001489 MMPL family; Region: MMPL; pfam03176 1112204001490 MMPL family; Region: MMPL; pfam03176 1112204001491 LabA_like proteins; Region: LabA_like; cd06167 1112204001492 putative metal binding site [ion binding]; other site 1112204001493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204001494 S-adenosylmethionine binding site [chemical binding]; other site 1112204001495 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1112204001496 active site 1112204001497 substrate-binding site [chemical binding]; other site 1112204001498 metal-binding site [ion binding] 1112204001499 GTP binding site [chemical binding]; other site 1112204001500 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1112204001501 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1112204001502 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1112204001503 Walker A/P-loop; other site 1112204001504 ATP binding site [chemical binding]; other site 1112204001505 Q-loop/lid; other site 1112204001506 ABC transporter signature motif; other site 1112204001507 Walker B; other site 1112204001508 D-loop; other site 1112204001509 H-loop/switch region; other site 1112204001510 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1112204001511 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1112204001512 FtsX-like permease family; Region: FtsX; pfam02687 1112204001513 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1112204001514 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1112204001515 FtsX-like permease family; Region: FtsX; pfam02687 1112204001516 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204001517 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001518 active site 1112204001519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204001520 S-adenosylmethionine binding site [chemical binding]; other site 1112204001521 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1112204001522 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1112204001523 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1112204001524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204001525 Ligand Binding Site [chemical binding]; other site 1112204001526 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1112204001527 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1112204001528 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1112204001529 G1 box; other site 1112204001530 GTP/Mg2+ binding site [chemical binding]; other site 1112204001531 G2 box; other site 1112204001532 Switch I region; other site 1112204001533 G3 box; other site 1112204001534 Switch II region; other site 1112204001535 G4 box; other site 1112204001536 G5 box; other site 1112204001537 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1112204001538 Dynamin family; Region: Dynamin_N; pfam00350 1112204001539 G1 box; other site 1112204001540 GTP/Mg2+ binding site [chemical binding]; other site 1112204001541 G2 box; other site 1112204001542 Switch I region; other site 1112204001543 G3 box; other site 1112204001544 Switch II region; other site 1112204001545 G4 box; other site 1112204001546 G5 box; other site 1112204001547 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204001548 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204001549 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204001550 DNA binding residues [nucleotide binding] 1112204001551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001553 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204001554 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204001555 active site 2 [active] 1112204001556 active site 1 [active] 1112204001557 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1112204001558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204001559 NAD(P) binding site [chemical binding]; other site 1112204001560 active site 1112204001561 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1112204001562 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204001563 dimer interface [polypeptide binding]; other site 1112204001564 active site 1112204001565 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1112204001566 VanW like protein; Region: VanW; pfam04294 1112204001567 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1112204001568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001570 WHG domain; Region: WHG; pfam13305 1112204001571 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1112204001572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204001573 NAD(P) binding site [chemical binding]; other site 1112204001574 active site 1112204001575 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1112204001576 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1112204001577 catalytic Zn binding site [ion binding]; other site 1112204001578 structural Zn binding site [ion binding]; other site 1112204001579 NAD(P) binding site [chemical binding]; other site 1112204001580 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1112204001581 hydrophobic ligand binding site; other site 1112204001582 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1112204001583 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1112204001584 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1112204001585 FAD binding site [chemical binding]; other site 1112204001586 substrate binding site [chemical binding]; other site 1112204001587 catalytic residues [active] 1112204001588 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1112204001589 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1112204001590 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1112204001591 active site 1112204001592 catalytic tetrad [active] 1112204001593 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001594 active site 1112204001595 endonuclease IV; Provisional; Region: PRK01060 1112204001596 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1112204001597 DNA interaction; other site 1112204001598 Metal-binding active site; metal-binding site 1112204001599 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1112204001600 active site 1112204001601 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1112204001602 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1112204001603 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1112204001604 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204001605 CoenzymeA binding site [chemical binding]; other site 1112204001606 subunit interaction site [polypeptide binding]; other site 1112204001607 PHB binding site; other site 1112204001608 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1112204001609 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1112204001610 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204001611 acyl-activating enzyme (AAE) consensus motif; other site 1112204001612 AMP binding site [chemical binding]; other site 1112204001613 active site 1112204001614 CoA binding site [chemical binding]; other site 1112204001615 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204001616 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1112204001617 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1112204001618 putative trimer interface [polypeptide binding]; other site 1112204001619 putative CoA binding site [chemical binding]; other site 1112204001620 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1112204001621 putative trimer interface [polypeptide binding]; other site 1112204001622 putative CoA binding site [chemical binding]; other site 1112204001623 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204001624 Domain of unknown function (DUF202); Region: DUF202; cl09954 1112204001625 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204001626 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204001627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204001628 Walker A/P-loop; other site 1112204001629 ATP binding site [chemical binding]; other site 1112204001630 Q-loop/lid; other site 1112204001631 ABC transporter signature motif; other site 1112204001632 Walker B; other site 1112204001633 D-loop; other site 1112204001634 H-loop/switch region; other site 1112204001635 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1112204001636 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1112204001637 siderophore binding site; other site 1112204001638 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1112204001639 active site 1112204001640 substrate binding site [chemical binding]; other site 1112204001641 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1112204001642 cosubstrate binding site; other site 1112204001643 catalytic site [active] 1112204001644 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1112204001645 substrate binding site [chemical binding]; other site 1112204001646 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1112204001647 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204001648 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204001649 acyl-activating enzyme (AAE) consensus motif; other site 1112204001650 AMP binding site [chemical binding]; other site 1112204001651 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204001652 Condensation domain; Region: Condensation; pfam00668 1112204001653 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1112204001654 Condensation domain; Region: Condensation; pfam00668 1112204001655 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204001656 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204001657 acyl-activating enzyme (AAE) consensus motif; other site 1112204001658 AMP binding site [chemical binding]; other site 1112204001659 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204001660 Condensation domain; Region: Condensation; pfam00668 1112204001661 Condensation domain; Region: Condensation; pfam00668 1112204001662 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204001663 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204001664 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204001665 acyl-activating enzyme (AAE) consensus motif; other site 1112204001666 AMP binding site [chemical binding]; other site 1112204001667 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204001668 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1112204001669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204001670 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204001671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204001672 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1112204001673 ABC transporter signature motif; other site 1112204001674 ABC transporter signature motif; other site 1112204001675 Walker B; other site 1112204001676 Walker B; other site 1112204001677 D-loop; other site 1112204001678 D-loop; other site 1112204001679 H-loop/switch region; other site 1112204001680 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204001681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204001682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204001683 Walker A/P-loop; other site 1112204001684 ATP binding site [chemical binding]; other site 1112204001685 Q-loop/lid; other site 1112204001686 ABC transporter signature motif; other site 1112204001687 Walker B; other site 1112204001688 D-loop; other site 1112204001689 H-loop/switch region; other site 1112204001690 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1112204001691 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1112204001692 Walker A/P-loop; other site 1112204001693 ATP binding site [chemical binding]; other site 1112204001694 Q-loop/lid; other site 1112204001695 ABC transporter signature motif; other site 1112204001696 Walker B; other site 1112204001697 D-loop; other site 1112204001698 H-loop/switch region; other site 1112204001699 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1112204001700 ABC-ATPase subunit interface; other site 1112204001701 dimer interface [polypeptide binding]; other site 1112204001702 putative PBP binding regions; other site 1112204001703 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1112204001704 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1112204001705 ABC-ATPase subunit interface; other site 1112204001706 dimer interface [polypeptide binding]; other site 1112204001707 putative PBP binding regions; other site 1112204001708 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1112204001709 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1112204001710 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204001711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204001712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204001713 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1112204001714 putative dimerization interface [polypeptide binding]; other site 1112204001715 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1112204001716 EamA-like transporter family; Region: EamA; pfam00892 1112204001717 EamA-like transporter family; Region: EamA; pfam00892 1112204001718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001720 phosphate acetyltransferase; Reviewed; Region: PRK05632 1112204001721 DRTGG domain; Region: DRTGG; pfam07085 1112204001722 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1112204001723 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1112204001724 propionate/acetate kinase; Provisional; Region: PRK12379 1112204001725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001727 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204001728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204001729 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204001730 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001731 active site 1112204001732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204001733 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204001734 active site 1112204001735 ATP binding site [chemical binding]; other site 1112204001736 substrate binding site [chemical binding]; other site 1112204001737 activation loop (A-loop); other site 1112204001738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1112204001739 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1112204001740 substrate binding pocket [chemical binding]; other site 1112204001741 membrane-bound complex binding site; other site 1112204001742 hinge residues; other site 1112204001743 NUDIX domain; Region: NUDIX; pfam00293 1112204001744 nudix motif; other site 1112204001745 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1112204001746 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1112204001747 active site 1112204001748 pyrophosphate binding site [ion binding]; other site 1112204001749 thiamine phosphate binding site [chemical binding]; other site 1112204001750 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1112204001751 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1112204001752 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1112204001753 thiS-thiF/thiG interaction site; other site 1112204001754 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1112204001755 ThiS interaction site; other site 1112204001756 putative active site [active] 1112204001757 tetramer interface [polypeptide binding]; other site 1112204001758 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1112204001759 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1112204001760 Walker A/P-loop; other site 1112204001761 ATP binding site [chemical binding]; other site 1112204001762 Q-loop/lid; other site 1112204001763 ABC transporter signature motif; other site 1112204001764 Walker B; other site 1112204001765 D-loop; other site 1112204001766 H-loop/switch region; other site 1112204001767 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1112204001768 AAA ATPase domain; Region: AAA_16; pfam13191 1112204001769 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1112204001770 Walker A motif; other site 1112204001771 ATP binding site [chemical binding]; other site 1112204001772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204001773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204001774 DNA binding residues [nucleotide binding] 1112204001775 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001776 active site 1112204001777 SnoaL-like domain; Region: SnoaL_4; pfam13577 1112204001778 SnoaL-like domain; Region: SnoaL_3; pfam13474 1112204001779 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1112204001780 hypothetical protein; Provisional; Region: PRK06849 1112204001781 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204001782 guanine deaminase; Provisional; Region: PRK09228 1112204001783 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1112204001784 active site 1112204001785 2-isopropylmalate synthase; Validated; Region: PRK03739 1112204001786 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1112204001787 active site 1112204001788 catalytic residues [active] 1112204001789 metal binding site [ion binding]; metal-binding site 1112204001790 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1112204001791 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1112204001792 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1112204001793 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1112204001794 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204001795 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204001796 active site 1112204001797 Condensation domain; Region: Condensation; pfam00668 1112204001798 Condensation domain; Region: Condensation; pfam00668 1112204001799 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1112204001800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1112204001801 active site 1112204001802 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1112204001803 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1112204001804 active site 1112204001805 TDP-binding site; other site 1112204001806 acceptor substrate-binding pocket; other site 1112204001807 homodimer interface [polypeptide binding]; other site 1112204001808 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1112204001809 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204001810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204001811 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1112204001812 Walker A/P-loop; other site 1112204001813 ATP binding site [chemical binding]; other site 1112204001814 Q-loop/lid; other site 1112204001815 ABC transporter signature motif; other site 1112204001816 Walker B; other site 1112204001817 D-loop; other site 1112204001818 H-loop/switch region; other site 1112204001819 Predicted ATPase [General function prediction only]; Region: COG3903 1112204001820 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1112204001821 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1112204001822 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1112204001823 FMN binding site [chemical binding]; other site 1112204001824 dimer interface [polypeptide binding]; other site 1112204001825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204001826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204001827 putative substrate translocation pore; other site 1112204001828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204001829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204001830 aspartate kinase; Reviewed; Region: PRK06635 1112204001831 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1112204001832 putative nucleotide binding site [chemical binding]; other site 1112204001833 putative catalytic residues [active] 1112204001834 putative Mg ion binding site [ion binding]; other site 1112204001835 putative aspartate binding site [chemical binding]; other site 1112204001836 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1112204001837 putative allosteric regulatory site; other site 1112204001838 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1112204001839 putative allosteric regulatory residue; other site 1112204001840 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1112204001841 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1112204001842 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1112204001843 active site 1112204001844 catalytic site [active] 1112204001845 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1112204001846 active site 1112204001847 catalytic site [active] 1112204001848 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1112204001849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204001850 DNA-binding site [nucleotide binding]; DNA binding site 1112204001851 FCD domain; Region: FCD; pfam07729 1112204001852 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1112204001853 GntP family permease; Region: GntP_permease; pfam02447 1112204001854 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1112204001855 Secretory lipase; Region: LIP; pfam03583 1112204001856 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1112204001857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1112204001858 active site 1112204001859 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204001860 oxidase reductase; Provisional; Region: PTZ00273 1112204001861 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204001862 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1112204001863 metal binding site 2 [ion binding]; metal-binding site 1112204001864 putative DNA binding helix; other site 1112204001865 metal binding site 1 [ion binding]; metal-binding site 1112204001866 dimer interface [polypeptide binding]; other site 1112204001867 structural Zn2+ binding site [ion binding]; other site 1112204001868 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1112204001869 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1112204001870 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1112204001871 dimerization interface [polypeptide binding]; other site 1112204001872 DPS ferroxidase diiron center [ion binding]; other site 1112204001873 ion pore; other site 1112204001874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204001875 dimerization interface [polypeptide binding]; other site 1112204001876 putative DNA binding site [nucleotide binding]; other site 1112204001877 putative Zn2+ binding site [ion binding]; other site 1112204001878 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1112204001879 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1112204001880 putative ligand binding site [chemical binding]; other site 1112204001881 amidase; Provisional; Region: PRK07235 1112204001882 amidase; Provisional; Region: PRK06061 1112204001883 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 1112204001884 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 1112204001885 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1112204001886 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1112204001887 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1112204001888 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1112204001889 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1112204001890 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1112204001891 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1112204001892 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1112204001893 dimer interface [polypeptide binding]; other site 1112204001894 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1112204001895 catalytic triad [active] 1112204001896 peroxidatic and resolving cysteines [active] 1112204001897 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1112204001898 heme-binding site [chemical binding]; other site 1112204001899 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1112204001900 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1112204001901 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1112204001902 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1112204001903 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1112204001904 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204001905 MULE transposase domain; Region: MULE; pfam10551 1112204001906 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204001907 MULE transposase domain; Region: MULE; pfam10551 1112204001908 HTH-like domain; Region: HTH_21; pfam13276 1112204001909 Transposase; Region: HTH_Tnp_1; pfam01527 1112204001910 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1112204001911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1112204001912 hypothetical protein; Provisional; Region: PRK07907 1112204001913 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1112204001914 active site 1112204001915 metal binding site [ion binding]; metal-binding site 1112204001916 dimer interface [polypeptide binding]; other site 1112204001917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204001918 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204001919 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1112204001920 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1112204001921 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204001922 substrate binding site [chemical binding]; other site 1112204001923 oxyanion hole (OAH) forming residues; other site 1112204001924 trimer interface [polypeptide binding]; other site 1112204001925 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1112204001926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204001927 motif II; other site 1112204001928 phosphodiesterase YaeI; Provisional; Region: PRK11340 1112204001929 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1112204001930 putative active site [active] 1112204001931 putative metal binding site [ion binding]; other site 1112204001932 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1112204001933 Transglycosylase; Region: Transgly; pfam00912 1112204001934 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1112204001935 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1112204001936 Transcription factor WhiB; Region: Whib; pfam02467 1112204001937 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1112204001938 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1112204001939 DTAP/Switch II; other site 1112204001940 Switch I; other site 1112204001941 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1112204001942 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1112204001943 DTAP/Switch II; other site 1112204001944 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1112204001945 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1112204001946 homotrimer interaction site [polypeptide binding]; other site 1112204001947 putative active site [active] 1112204001948 hypothetical protein; Provisional; Region: PRK10621 1112204001949 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1112204001950 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1112204001951 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1112204001952 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1112204001953 ligand binding site [chemical binding]; other site 1112204001954 flexible hinge region; other site 1112204001955 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1112204001956 putative switch regulator; other site 1112204001957 non-specific DNA interactions [nucleotide binding]; other site 1112204001958 DNA binding site [nucleotide binding] 1112204001959 sequence specific DNA binding site [nucleotide binding]; other site 1112204001960 putative cAMP binding site [chemical binding]; other site 1112204001961 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1112204001962 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1112204001963 minor groove reading motif; other site 1112204001964 helix-hairpin-helix signature motif; other site 1112204001965 substrate binding pocket [chemical binding]; other site 1112204001966 active site 1112204001967 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1112204001968 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1112204001969 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1112204001970 catalytic residues [active] 1112204001971 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1112204001972 putative active site [active] 1112204001973 putative CoA binding site [chemical binding]; other site 1112204001974 nudix motif; other site 1112204001975 metal binding site [ion binding]; metal-binding site 1112204001976 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1112204001977 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1112204001978 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204001979 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1112204001980 acetyl-CoA synthetase; Provisional; Region: PRK00174 1112204001981 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1112204001982 active site 1112204001983 CoA binding site [chemical binding]; other site 1112204001984 acyl-activating enzyme (AAE) consensus motif; other site 1112204001985 AMP binding site [chemical binding]; other site 1112204001986 acetate binding site [chemical binding]; other site 1112204001987 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1112204001988 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1112204001989 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1112204001990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204001991 dimer interface [polypeptide binding]; other site 1112204001992 conserved gate region; other site 1112204001993 putative PBP binding loops; other site 1112204001994 ABC-ATPase subunit interface; other site 1112204001995 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1112204001996 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1112204001997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204001998 dimer interface [polypeptide binding]; other site 1112204001999 conserved gate region; other site 1112204002000 putative PBP binding loops; other site 1112204002001 ABC-ATPase subunit interface; other site 1112204002002 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1112204002003 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204002004 Walker A/P-loop; other site 1112204002005 ATP binding site [chemical binding]; other site 1112204002006 Q-loop/lid; other site 1112204002007 ABC transporter signature motif; other site 1112204002008 Walker B; other site 1112204002009 D-loop; other site 1112204002010 H-loop/switch region; other site 1112204002011 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1112204002012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204002013 Walker A/P-loop; other site 1112204002014 ATP binding site [chemical binding]; other site 1112204002015 Q-loop/lid; other site 1112204002016 ABC transporter signature motif; other site 1112204002017 Walker B; other site 1112204002018 D-loop; other site 1112204002019 H-loop/switch region; other site 1112204002020 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1112204002021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204002022 motif II; other site 1112204002023 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1112204002024 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1112204002025 Type II/IV secretion system protein; Region: T2SE; pfam00437 1112204002026 Walker A motif; other site 1112204002027 ATP binding site [chemical binding]; other site 1112204002028 Walker B motif; other site 1112204002029 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1112204002030 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1112204002031 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1112204002032 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1112204002033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204002034 ATP binding site [chemical binding]; other site 1112204002035 putative Mg++ binding site [ion binding]; other site 1112204002036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204002037 nucleotide binding region [chemical binding]; other site 1112204002038 ATP-binding site [chemical binding]; other site 1112204002039 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1112204002040 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1112204002041 DNA-binding site [nucleotide binding]; DNA binding site 1112204002042 RNA-binding motif; other site 1112204002043 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1112204002044 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 1112204002045 active site 1112204002046 interdomain interaction site; other site 1112204002047 putative metal-binding site [ion binding]; other site 1112204002048 nucleotide binding site [chemical binding]; other site 1112204002049 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1112204002050 domain I; other site 1112204002051 phosphate binding site [ion binding]; other site 1112204002052 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1112204002053 domain II; other site 1112204002054 domain III; other site 1112204002055 nucleotide binding site [chemical binding]; other site 1112204002056 DNA binding groove [nucleotide binding] 1112204002057 catalytic site [active] 1112204002058 domain IV; other site 1112204002059 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1112204002060 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 1112204002061 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1112204002062 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1112204002063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204002064 dimerization interface [polypeptide binding]; other site 1112204002065 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1112204002066 cyclase homology domain; Region: CHD; cd07302 1112204002067 nucleotidyl binding site; other site 1112204002068 metal binding site [ion binding]; metal-binding site 1112204002069 dimer interface [polypeptide binding]; other site 1112204002070 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1112204002071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1112204002072 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1112204002073 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1112204002074 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1112204002075 Walker A/P-loop; other site 1112204002076 ATP binding site [chemical binding]; other site 1112204002077 Q-loop/lid; other site 1112204002078 ABC transporter signature motif; other site 1112204002079 Walker B; other site 1112204002080 D-loop; other site 1112204002081 H-loop/switch region; other site 1112204002082 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1112204002083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1112204002084 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1112204002085 NMT1/THI5 like; Region: NMT1; pfam09084 1112204002086 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1112204002087 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1112204002088 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1112204002089 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1112204002090 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1112204002091 putative active site [active] 1112204002092 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1112204002093 Lipase (class 2); Region: Lipase_2; pfam01674 1112204002094 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204002095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204002096 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1112204002097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204002098 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1112204002099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204002100 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1112204002101 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1112204002102 aromatic arch; other site 1112204002103 DCoH dimer interaction site [polypeptide binding]; other site 1112204002104 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1112204002105 DCoH tetramer interaction site [polypeptide binding]; other site 1112204002106 substrate binding site [chemical binding]; other site 1112204002107 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1112204002108 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1112204002109 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1112204002110 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1112204002111 putative NAD(P) binding site [chemical binding]; other site 1112204002112 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1112204002113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204002114 DNA-binding site [nucleotide binding]; DNA binding site 1112204002115 FCD domain; Region: FCD; pfam07729 1112204002116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204002117 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204002118 putative DNA binding site [nucleotide binding]; other site 1112204002119 putative Zn2+ binding site [ion binding]; other site 1112204002120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204002121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204002122 putative substrate translocation pore; other site 1112204002123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204002124 UDP-glucose 4-epimerase; Region: PLN02240 1112204002125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204002126 NAD(P) binding site [chemical binding]; other site 1112204002127 active site 1112204002128 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1112204002129 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1112204002130 NAD binding site [chemical binding]; other site 1112204002131 substrate binding site [chemical binding]; other site 1112204002132 homodimer interface [polypeptide binding]; other site 1112204002133 active site 1112204002134 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1112204002135 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1112204002136 substrate binding site; other site 1112204002137 tetramer interface; other site 1112204002138 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1112204002139 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1112204002140 Peptidase family M1; Region: Peptidase_M1; pfam01433 1112204002141 Zn binding site [ion binding]; other site 1112204002142 Predicted membrane protein [Function unknown]; Region: COG2259 1112204002143 Clp amino terminal domain; Region: Clp_N; pfam02861 1112204002144 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1112204002145 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1112204002146 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1112204002147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1112204002148 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1112204002149 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204002150 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1112204002151 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1112204002152 Short C-terminal domain; Region: SHOCT; pfam09851 1112204002153 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1112204002154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204002155 active site 1112204002156 motif I; other site 1112204002157 motif II; other site 1112204002158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204002159 active site 1112204002160 motif I; other site 1112204002161 motif II; other site 1112204002162 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204002163 active site 1112204002164 metal binding site [ion binding]; metal-binding site 1112204002165 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204002166 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1112204002167 dimer interface [polypeptide binding]; other site 1112204002168 substrate binding site [chemical binding]; other site 1112204002169 ATP binding site [chemical binding]; other site 1112204002170 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1112204002171 ThiC-associated domain; Region: ThiC-associated; pfam13667 1112204002172 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1112204002173 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1112204002174 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1112204002175 FAD binding pocket [chemical binding]; other site 1112204002176 FAD binding motif [chemical binding]; other site 1112204002177 phosphate binding motif [ion binding]; other site 1112204002178 NAD binding pocket [chemical binding]; other site 1112204002179 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1112204002180 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1112204002181 intersubunit interface [polypeptide binding]; other site 1112204002182 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1112204002183 RNAase interaction site [polypeptide binding]; other site 1112204002184 ribonuclease; Region: Ribonuclease; pfam00545 1112204002185 active site 1112204002186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204002187 Coenzyme A binding pocket [chemical binding]; other site 1112204002188 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1112204002189 active site 1112204002190 catalytic residues [active] 1112204002191 metal binding site [ion binding]; metal-binding site 1112204002192 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1112204002193 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1112204002194 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1112204002195 E-class dimer interface [polypeptide binding]; other site 1112204002196 P-class dimer interface [polypeptide binding]; other site 1112204002197 active site 1112204002198 Cu2+ binding site [ion binding]; other site 1112204002199 Zn2+ binding site [ion binding]; other site 1112204002200 carboxylate-amine ligase; Provisional; Region: PRK13517 1112204002201 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1112204002202 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1112204002203 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204002204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002205 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1112204002206 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1112204002207 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1112204002208 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1112204002209 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1112204002210 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1112204002211 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1112204002212 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1112204002213 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1112204002214 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1112204002215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1112204002216 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1112204002217 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1112204002218 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1112204002219 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1112204002220 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1112204002221 dimer interface [polypeptide binding]; other site 1112204002222 NADP binding site [chemical binding]; other site 1112204002223 catalytic residues [active] 1112204002224 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1112204002225 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1112204002226 inhibitor site; inhibition site 1112204002227 active site 1112204002228 dimer interface [polypeptide binding]; other site 1112204002229 catalytic residue [active] 1112204002230 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1112204002231 Proline racemase; Region: Pro_racemase; pfam05544 1112204002232 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1112204002233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204002234 DNA-binding site [nucleotide binding]; DNA binding site 1112204002235 FCD domain; Region: FCD; pfam07729 1112204002236 Winged helix-turn helix; Region: HTH_29; pfam13551 1112204002237 Homeodomain-like domain; Region: HTH_32; pfam13565 1112204002238 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204002239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1112204002240 DNA-binding site [nucleotide binding]; DNA binding site 1112204002241 FCD domain; Region: FCD; pfam07729 1112204002242 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1112204002243 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1112204002244 putative active site [active] 1112204002245 putative FMN binding site [chemical binding]; other site 1112204002246 putative substrate binding site [chemical binding]; other site 1112204002247 putative catalytic residue [active] 1112204002248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204002249 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1112204002250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204002251 putative substrate translocation pore; other site 1112204002252 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1112204002253 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1112204002254 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1112204002255 dinuclear metal binding motif [ion binding]; other site 1112204002256 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 1112204002257 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1112204002258 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1112204002259 dinuclear metal binding motif [ion binding]; other site 1112204002260 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1112204002261 iron-sulfur cluster [ion binding]; other site 1112204002262 [2Fe-2S] cluster binding site [ion binding]; other site 1112204002263 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1112204002264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204002265 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1112204002266 protein-rRNA interface [nucleotide binding]; other site 1112204002267 putative translocon binding site; other site 1112204002268 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1112204002269 SnoaL-like domain; Region: SnoaL_3; pfam13474 1112204002270 SnoaL-like domain; Region: SnoaL_2; pfam12680 1112204002271 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1112204002272 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1112204002273 potential catalytic triad [active] 1112204002274 conserved cys residue [active] 1112204002275 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1112204002276 putative hydrophobic ligand binding site [chemical binding]; other site 1112204002277 protein interface [polypeptide binding]; other site 1112204002278 gate; other site 1112204002279 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 1112204002280 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1112204002281 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1112204002282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204002283 Walker A motif; other site 1112204002284 ATP binding site [chemical binding]; other site 1112204002285 Walker B motif; other site 1112204002286 arginine finger; other site 1112204002287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204002288 Walker A motif; other site 1112204002289 ATP binding site [chemical binding]; other site 1112204002290 Walker B motif; other site 1112204002291 arginine finger; other site 1112204002292 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1112204002293 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1112204002294 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1112204002295 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204002296 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204002297 active site 1112204002298 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1112204002299 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1112204002300 dimer interface [polypeptide binding]; other site 1112204002301 putative functional site; other site 1112204002302 putative MPT binding site; other site 1112204002303 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1112204002304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204002305 active site 1112204002306 motif I; other site 1112204002307 motif II; other site 1112204002308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204002309 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1112204002310 hydrophobic ligand binding site; other site 1112204002311 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1112204002312 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1112204002313 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204002314 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1112204002315 active site 1112204002316 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1112204002317 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1112204002318 FAD binding site [chemical binding]; other site 1112204002319 substrate binding site [chemical binding]; other site 1112204002320 catalytic base [active] 1112204002321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204002322 Putative esterase; Region: Esterase; pfam00756 1112204002323 amidase; Provisional; Region: PRK07869 1112204002324 Amidase; Region: Amidase; cl11426 1112204002325 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1112204002326 HIT family signature motif; other site 1112204002327 catalytic residue [active] 1112204002328 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1112204002329 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1112204002330 Na binding site [ion binding]; other site 1112204002331 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1112204002332 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1112204002333 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1112204002334 active site 1112204002335 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1112204002336 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1112204002337 Na binding site [ion binding]; other site 1112204002338 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1112204002339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204002340 active site 1112204002341 phosphorylation site [posttranslational modification] 1112204002342 intermolecular recognition site; other site 1112204002343 dimerization interface [polypeptide binding]; other site 1112204002344 LytTr DNA-binding domain; Region: LytTR; smart00850 1112204002345 Histidine kinase; Region: His_kinase; pfam06580 1112204002346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204002347 ATP binding site [chemical binding]; other site 1112204002348 Mg2+ binding site [ion binding]; other site 1112204002349 G-X-G motif; other site 1112204002350 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1112204002351 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 1112204002352 acyl-activating enzyme (AAE) consensus motif; other site 1112204002353 putative AMP binding site [chemical binding]; other site 1112204002354 putative active site [active] 1112204002355 putative CoA binding site [chemical binding]; other site 1112204002356 Putative cyclase; Region: Cyclase; pfam04199 1112204002357 Putative cyclase; Region: Cyclase; cl00814 1112204002358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204002359 sequence-specific DNA binding site [nucleotide binding]; other site 1112204002360 salt bridge; other site 1112204002361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204002362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002363 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204002364 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1112204002365 acyl-activating enzyme (AAE) consensus motif; other site 1112204002366 AMP binding site [chemical binding]; other site 1112204002367 active site 1112204002368 CoA binding site [chemical binding]; other site 1112204002369 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1112204002370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204002371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204002372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204002373 homodimer interface [polypeptide binding]; other site 1112204002374 catalytic residue [active] 1112204002375 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1112204002376 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1112204002377 active site 1112204002378 catalytic triad [active] 1112204002379 dimer interface [polypeptide binding]; other site 1112204002380 phenylhydantoinase; Validated; Region: PRK08323 1112204002381 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1112204002382 tetramer interface [polypeptide binding]; other site 1112204002383 active site 1112204002384 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204002385 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 1112204002386 hypothetical protein; Provisional; Region: PRK06062 1112204002387 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204002388 inhibitor-cofactor binding pocket; inhibition site 1112204002389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204002390 catalytic residue [active] 1112204002391 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1112204002392 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1112204002393 tetrameric interface [polypeptide binding]; other site 1112204002394 NAD binding site [chemical binding]; other site 1112204002395 catalytic residues [active] 1112204002396 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1112204002397 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1112204002398 Na binding site [ion binding]; other site 1112204002399 putative substrate binding site [chemical binding]; other site 1112204002400 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204002401 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204002402 active site 1112204002403 ATP binding site [chemical binding]; other site 1112204002404 substrate binding site [chemical binding]; other site 1112204002405 activation loop (A-loop); other site 1112204002406 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1112204002407 putative trimer interface [polypeptide binding]; other site 1112204002408 putative CoA binding site [chemical binding]; other site 1112204002409 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1112204002410 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1112204002411 putative dimer interface [polypeptide binding]; other site 1112204002412 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1112204002413 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1112204002414 Walker A/P-loop; other site 1112204002415 ATP binding site [chemical binding]; other site 1112204002416 Q-loop/lid; other site 1112204002417 ABC transporter signature motif; other site 1112204002418 Walker B; other site 1112204002419 D-loop; other site 1112204002420 H-loop/switch region; other site 1112204002421 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1112204002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204002423 dimer interface [polypeptide binding]; other site 1112204002424 conserved gate region; other site 1112204002425 putative PBP binding loops; other site 1112204002426 ABC-ATPase subunit interface; other site 1112204002427 oxidase reductase; Provisional; Region: PTZ00273 1112204002428 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204002429 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204002430 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204002431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204002432 DNA-binding site [nucleotide binding]; DNA binding site 1112204002433 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1112204002434 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1112204002435 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1112204002436 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1112204002437 ring oligomerisation interface [polypeptide binding]; other site 1112204002438 ATP/Mg binding site [chemical binding]; other site 1112204002439 stacking interactions; other site 1112204002440 hinge regions; other site 1112204002441 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1112204002442 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1112204002443 catalytic residues [active] 1112204002444 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204002445 acyl-CoA synthetase; Validated; Region: PRK08316 1112204002446 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204002447 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204002448 acyl-activating enzyme (AAE) consensus motif; other site 1112204002449 acyl-activating enzyme (AAE) consensus motif; other site 1112204002450 putative AMP binding site [chemical binding]; other site 1112204002451 putative active site [active] 1112204002452 putative CoA binding site [chemical binding]; other site 1112204002453 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204002454 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1112204002455 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204002456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204002457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204002458 DNA binding residues [nucleotide binding] 1112204002459 dimerization interface [polypeptide binding]; other site 1112204002460 short chain dehydrogenase; Provisional; Region: PRK08278 1112204002461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204002462 NAD(P) binding site [chemical binding]; other site 1112204002463 active site 1112204002464 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204002465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204002466 non-specific DNA binding site [nucleotide binding]; other site 1112204002467 salt bridge; other site 1112204002468 sequence-specific DNA binding site [nucleotide binding]; other site 1112204002469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204002471 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1112204002472 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1112204002473 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204002474 CoenzymeA binding site [chemical binding]; other site 1112204002475 subunit interaction site [polypeptide binding]; other site 1112204002476 PHB binding site; other site 1112204002477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204002478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002479 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1112204002480 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1112204002481 putative hydrophobic ligand binding site [chemical binding]; other site 1112204002482 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1112204002483 Secretory lipase; Region: LIP; pfam03583 1112204002484 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1112204002485 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1112204002486 putative metal binding site [ion binding]; other site 1112204002487 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1112204002488 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1112204002489 nucleotide binding site [chemical binding]; other site 1112204002490 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1112204002491 SBD interface [polypeptide binding]; other site 1112204002492 GrpE; Region: GrpE; pfam01025 1112204002493 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1112204002494 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204002495 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204002496 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204002497 active site 1112204002498 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1112204002499 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1112204002500 active site 1112204002501 FMN binding site [chemical binding]; other site 1112204002502 substrate binding site [chemical binding]; other site 1112204002503 putative catalytic residue [active] 1112204002504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204002505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002506 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1112204002507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204002508 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1112204002509 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1112204002510 minor groove reading motif; other site 1112204002511 helix-hairpin-helix signature motif; other site 1112204002512 active site 1112204002513 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1112204002514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204002515 putative PBP binding loops; other site 1112204002516 dimer interface [polypeptide binding]; other site 1112204002517 ABC-ATPase subunit interface; other site 1112204002518 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1112204002519 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1112204002520 Walker A/P-loop; other site 1112204002521 ATP binding site [chemical binding]; other site 1112204002522 Q-loop/lid; other site 1112204002523 ABC transporter signature motif; other site 1112204002524 Walker B; other site 1112204002525 D-loop; other site 1112204002526 H-loop/switch region; other site 1112204002527 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1112204002528 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1112204002529 substrate binding pocket [chemical binding]; other site 1112204002530 membrane-bound complex binding site; other site 1112204002531 hinge residues; other site 1112204002532 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1112204002533 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1112204002534 active site 1112204002535 dimer interface [polypeptide binding]; other site 1112204002536 non-prolyl cis peptide bond; other site 1112204002537 insertion regions; other site 1112204002538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204002539 S-adenosylmethionine binding site [chemical binding]; other site 1112204002540 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1112204002541 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1112204002542 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1112204002543 putative active site [active] 1112204002544 putative catalytic site [active] 1112204002545 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204002546 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204002547 active site 1112204002548 ATP binding site [chemical binding]; other site 1112204002549 substrate binding site [chemical binding]; other site 1112204002550 activation loop (A-loop); other site 1112204002551 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204002552 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204002553 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204002554 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204002555 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204002556 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204002557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204002558 non-specific DNA binding site [nucleotide binding]; other site 1112204002559 salt bridge; other site 1112204002560 sequence-specific DNA binding site [nucleotide binding]; other site 1112204002561 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1112204002562 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1112204002563 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1112204002564 isocitrate lyase; Provisional; Region: PRK15063 1112204002565 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1112204002566 tetramer interface [polypeptide binding]; other site 1112204002567 active site 1112204002568 Mg2+/Mn2+ binding site [ion binding]; other site 1112204002569 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1112204002570 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1112204002571 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1112204002572 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204002573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204002574 non-specific DNA binding site [nucleotide binding]; other site 1112204002575 salt bridge; other site 1112204002576 sequence-specific DNA binding site [nucleotide binding]; other site 1112204002577 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1112204002578 benzoate transporter; Region: benE; TIGR00843 1112204002579 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204002580 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204002581 active site 1112204002582 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1112204002583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204002584 short chain dehydrogenase; Provisional; Region: PRK08303 1112204002585 NAD(P) binding site [chemical binding]; other site 1112204002586 active site 1112204002587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204002588 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1112204002589 DNA-binding interface [nucleotide binding]; DNA binding site 1112204002590 Predicted membrane protein [Function unknown]; Region: COG2733 1112204002591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204002592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204002593 non-specific DNA binding site [nucleotide binding]; other site 1112204002594 salt bridge; other site 1112204002595 sequence-specific DNA binding site [nucleotide binding]; other site 1112204002596 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1112204002597 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1112204002598 Predicted transcriptional regulator [Transcription]; Region: COG1959 1112204002599 Transcriptional regulator; Region: Rrf2; pfam02082 1112204002600 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1112204002601 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1112204002602 heme-binding site [chemical binding]; other site 1112204002603 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1112204002604 FAD binding pocket [chemical binding]; other site 1112204002605 FAD binding motif [chemical binding]; other site 1112204002606 phosphate binding motif [ion binding]; other site 1112204002607 beta-alpha-beta structure motif; other site 1112204002608 NAD binding pocket [chemical binding]; other site 1112204002609 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1112204002610 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204002611 DNA binding residues [nucleotide binding] 1112204002612 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204002613 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1112204002614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1112204002615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204002616 dimerization interface [polypeptide binding]; other site 1112204002617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204002618 dimer interface [polypeptide binding]; other site 1112204002619 phosphorylation site [posttranslational modification] 1112204002620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204002621 Mg2+ binding site [ion binding]; other site 1112204002622 G-X-G motif; other site 1112204002623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204002624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204002625 active site 1112204002626 phosphorylation site [posttranslational modification] 1112204002627 intermolecular recognition site; other site 1112204002628 dimerization interface [polypeptide binding]; other site 1112204002629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204002630 DNA binding site [nucleotide binding] 1112204002631 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1112204002632 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1112204002633 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204002634 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204002635 active site 1112204002636 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1112204002637 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204002638 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1112204002639 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1112204002640 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1112204002641 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1112204002642 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1112204002643 putative active site [active] 1112204002644 catalytic triad [active] 1112204002645 putative dimer interface [polypeptide binding]; other site 1112204002646 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1112204002647 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1112204002648 intersubunit interface [polypeptide binding]; other site 1112204002649 active site 1112204002650 catalytic residue [active] 1112204002651 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1112204002652 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1112204002653 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1112204002654 putative active site [active] 1112204002655 putative substrate binding site [chemical binding]; other site 1112204002656 putative cosubstrate binding site; other site 1112204002657 catalytic site [active] 1112204002658 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1112204002659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204002660 S-adenosylmethionine binding site [chemical binding]; other site 1112204002661 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204002662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204002663 non-specific DNA binding site [nucleotide binding]; other site 1112204002664 salt bridge; other site 1112204002665 sequence-specific DNA binding site [nucleotide binding]; other site 1112204002666 Cupin domain; Region: Cupin_2; pfam07883 1112204002667 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1112204002668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1112204002669 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1112204002670 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1112204002671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204002672 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1112204002673 NAD(P) binding site [chemical binding]; other site 1112204002674 active site 1112204002675 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1112204002676 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1112204002677 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204002678 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1112204002679 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1112204002680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1112204002681 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1112204002682 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1112204002683 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1112204002684 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1112204002685 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1112204002686 active site 1112204002687 homotetramer interface [polypeptide binding]; other site 1112204002688 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1112204002689 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1112204002690 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1112204002691 Amidinotransferase; Region: Amidinotransf; cl12043 1112204002692 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1112204002693 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1112204002694 substrate binding pocket [chemical binding]; other site 1112204002695 catalytic triad [active] 1112204002696 Helix-turn-helix domain; Region: HTH_38; pfam13936 1112204002697 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1112204002698 Integrase core domain; Region: rve; pfam00665 1112204002699 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204002700 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204002701 active site 1112204002702 selenium donor protein; Region: selD; TIGR00476 1112204002703 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1112204002704 dimerization interface [polypeptide binding]; other site 1112204002705 putative ATP binding site [chemical binding]; other site 1112204002706 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1112204002707 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1112204002708 metal binding site [ion binding]; metal-binding site 1112204002709 active site 1112204002710 I-site; other site 1112204002711 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1112204002712 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1112204002713 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1112204002714 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1112204002715 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1112204002716 molybdopterin cofactor binding site; other site 1112204002717 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1112204002718 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1112204002719 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1112204002720 substrate binding site; other site 1112204002721 dimer interface; other site 1112204002722 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1112204002723 homotrimer interaction site [polypeptide binding]; other site 1112204002724 zinc binding site [ion binding]; other site 1112204002725 CDP-binding sites; other site 1112204002726 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204002727 nucleotide binding site [chemical binding]; other site 1112204002728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1112204002729 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1112204002730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204002731 nucleotide binding site [chemical binding]; other site 1112204002732 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1112204002733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204002734 NAD(P) binding site [chemical binding]; other site 1112204002735 active site 1112204002736 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1112204002737 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1112204002738 dihydroxyacetone kinase; Provisional; Region: PRK14479 1112204002739 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1112204002740 DAK2 domain; Region: Dak2; pfam02734 1112204002741 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1112204002742 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1112204002743 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1112204002744 active site 1112204002745 HIGH motif; other site 1112204002746 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1112204002747 KMSKS motif; other site 1112204002748 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1112204002749 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1112204002750 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1112204002751 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1112204002752 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1112204002753 putative active site [active] 1112204002754 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1112204002755 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1112204002756 substrate binding pocket [chemical binding]; other site 1112204002757 catalytic triad [active] 1112204002758 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204002759 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 1112204002760 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1112204002761 DXD motif; other site 1112204002762 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1112204002763 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1112204002764 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1112204002765 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1112204002766 ABC-ATPase subunit interface; other site 1112204002767 putative PBP binding regions; other site 1112204002768 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1112204002769 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1112204002770 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1112204002771 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1112204002772 intersubunit interface [polypeptide binding]; other site 1112204002773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204002774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002775 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204002776 Cytochrome P450; Region: p450; cl12078 1112204002777 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1112204002778 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1112204002779 putative ADP-binding pocket [chemical binding]; other site 1112204002780 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1112204002781 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204002782 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204002783 active site 1112204002784 4-coumarate--CoA ligase; Region: PLN02246 1112204002785 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 1112204002786 acyl-activating enzyme (AAE) consensus motif; other site 1112204002787 active site 1112204002788 putative CoA binding site [chemical binding]; other site 1112204002789 AMP binding site [chemical binding]; other site 1112204002790 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1112204002791 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204002792 catalytic core [active] 1112204002793 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204002794 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1112204002795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204002796 dimer interface [polypeptide binding]; other site 1112204002797 phosphorylation site [posttranslational modification] 1112204002798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204002799 ATP binding site [chemical binding]; other site 1112204002800 Mg2+ binding site [ion binding]; other site 1112204002801 G-X-G motif; other site 1112204002802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204002803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204002804 active site 1112204002805 phosphorylation site [posttranslational modification] 1112204002806 intermolecular recognition site; other site 1112204002807 dimerization interface [polypeptide binding]; other site 1112204002808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204002809 DNA binding site [nucleotide binding] 1112204002810 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1112204002811 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1112204002812 DoxX; Region: DoxX; pfam07681 1112204002813 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1112204002814 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1112204002815 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1112204002816 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1112204002817 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1112204002818 DNA binding domain, excisionase family; Region: excise; TIGR01764 1112204002819 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1112204002820 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1112204002821 putative NAD(P) binding site [chemical binding]; other site 1112204002822 active site 1112204002823 putative substrate binding site [chemical binding]; other site 1112204002824 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1112204002825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1112204002826 putative acyl-acceptor binding pocket; other site 1112204002827 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1112204002828 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1112204002829 putative NAD(P) binding site [chemical binding]; other site 1112204002830 catalytic Zn binding site [ion binding]; other site 1112204002831 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1112204002832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204002833 motif II; other site 1112204002834 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1112204002835 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1112204002836 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1112204002837 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1112204002838 tRNA; other site 1112204002839 putative tRNA binding site [nucleotide binding]; other site 1112204002840 putative NADP binding site [chemical binding]; other site 1112204002841 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1112204002842 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1112204002843 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1112204002844 domain interfaces; other site 1112204002845 active site 1112204002846 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1112204002847 active site 1112204002848 homodimer interface [polypeptide binding]; other site 1112204002849 SAM binding site [chemical binding]; other site 1112204002850 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1112204002851 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1112204002852 active site 1112204002853 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1112204002854 dimer interface [polypeptide binding]; other site 1112204002855 active site 1112204002856 Schiff base residues; other site 1112204002857 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204002858 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204002859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204002860 active site 1112204002861 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1112204002862 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204002863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204002864 DNA binding residues [nucleotide binding] 1112204002865 dimerization interface [polypeptide binding]; other site 1112204002866 acyl-CoA synthetase; Validated; Region: PRK08162 1112204002867 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1112204002868 acyl-activating enzyme (AAE) consensus motif; other site 1112204002869 putative active site [active] 1112204002870 AMP binding site [chemical binding]; other site 1112204002871 putative CoA binding site [chemical binding]; other site 1112204002872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204002874 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1112204002875 FAD binding site [chemical binding]; other site 1112204002876 homotetramer interface [polypeptide binding]; other site 1112204002877 substrate binding pocket [chemical binding]; other site 1112204002878 catalytic base [active] 1112204002879 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1112204002880 putative active site [active] 1112204002881 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204002882 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1112204002883 tetramerization interface [polypeptide binding]; other site 1112204002884 NAD(P) binding site [chemical binding]; other site 1112204002885 catalytic residues [active] 1112204002886 tyramine oxidase; Provisional; Region: tynA; PRK11504 1112204002887 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1112204002888 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1112204002889 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1112204002890 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1112204002891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204002892 inhibitor-cofactor binding pocket; inhibition site 1112204002893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204002894 catalytic residue [active] 1112204002895 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1112204002896 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204002897 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1112204002898 active site 1112204002899 catalytic triad [active] 1112204002900 oxyanion hole [active] 1112204002901 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1112204002902 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204002903 inhibitor-cofactor binding pocket; inhibition site 1112204002904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204002905 catalytic residue [active] 1112204002906 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204002907 catalytic core [active] 1112204002908 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1112204002909 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1112204002910 catalytic residues [active] 1112204002911 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1112204002912 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1112204002913 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1112204002914 ResB-like family; Region: ResB; pfam05140 1112204002915 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1112204002916 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1112204002917 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204002918 DNA binding residues [nucleotide binding] 1112204002919 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1112204002920 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1112204002921 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1112204002922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204002923 catalytic residue [active] 1112204002924 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1112204002925 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1112204002926 Walker A/P-loop; other site 1112204002927 ATP binding site [chemical binding]; other site 1112204002928 Q-loop/lid; other site 1112204002929 ABC transporter signature motif; other site 1112204002930 Walker B; other site 1112204002931 D-loop; other site 1112204002932 H-loop/switch region; other site 1112204002933 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1112204002934 FtsX-like permease family; Region: FtsX; pfam02687 1112204002935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1112204002936 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1112204002937 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1112204002938 FAD binding pocket [chemical binding]; other site 1112204002939 FAD binding motif [chemical binding]; other site 1112204002940 phosphate binding motif [ion binding]; other site 1112204002941 NAD binding pocket [chemical binding]; other site 1112204002942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204002944 putative substrate translocation pore; other site 1112204002945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204002946 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1112204002947 UbiA prenyltransferase family; Region: UbiA; pfam01040 1112204002948 Ion channel; Region: Ion_trans_2; pfam07885 1112204002949 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1112204002950 Protease prsW family; Region: PrsW-protease; cl15823 1112204002951 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1112204002952 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1112204002953 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1112204002954 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1112204002955 PLD-like domain; Region: PLDc_2; pfam13091 1112204002956 putative active site [active] 1112204002957 catalytic site [active] 1112204002958 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204002959 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204002960 active site 1112204002961 active site 1112204002962 catalytic triad [active] 1112204002963 oxyanion hole [active] 1112204002964 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1112204002965 Secretory lipase; Region: LIP; pfam03583 1112204002966 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1112204002967 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1112204002968 DXD motif; other site 1112204002969 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1112204002970 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1112204002971 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1112204002972 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1112204002973 NAD binding site [chemical binding]; other site 1112204002974 substrate binding site [chemical binding]; other site 1112204002975 homodimer interface [polypeptide binding]; other site 1112204002976 active site 1112204002977 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1112204002978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204002979 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1112204002980 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1112204002981 substrate binding site; other site 1112204002982 tetramer interface; other site 1112204002983 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1112204002984 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1112204002985 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1112204002986 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1112204002987 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1112204002988 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1112204002989 O-Antigen ligase; Region: Wzy_C; pfam04932 1112204002990 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1112204002991 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1112204002992 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1112204002993 active site 1112204002994 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1112204002995 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1112204002996 active site 1112204002997 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1112204002998 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1112204002999 Chain length determinant protein; Region: Wzz; cl15801 1112204003000 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1112204003001 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204003002 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1112204003003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204003004 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1112204003005 Walker A/P-loop; other site 1112204003006 ATP binding site [chemical binding]; other site 1112204003007 Q-loop/lid; other site 1112204003008 ABC transporter signature motif; other site 1112204003009 Walker B; other site 1112204003010 D-loop; other site 1112204003011 H-loop/switch region; other site 1112204003012 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1112204003013 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204003014 Condensation domain; Region: Condensation; pfam00668 1112204003015 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204003016 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204003017 acyl-activating enzyme (AAE) consensus motif; other site 1112204003018 AMP binding site [chemical binding]; other site 1112204003019 Condensation domain; Region: Condensation; pfam00668 1112204003020 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204003021 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204003022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204003023 Condensation domain; Region: Condensation; pfam00668 1112204003024 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204003025 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204003026 acyl-activating enzyme (AAE) consensus motif; other site 1112204003027 AMP binding site [chemical binding]; other site 1112204003028 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204003029 Condensation domain; Region: Condensation; pfam00668 1112204003030 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204003031 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204003032 acyl-activating enzyme (AAE) consensus motif; other site 1112204003033 AMP binding site [chemical binding]; other site 1112204003034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204003035 Condensation domain; Region: Condensation; pfam00668 1112204003036 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204003037 Condensation domain; Region: Condensation; pfam00668 1112204003038 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204003039 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204003040 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204003041 acyl-activating enzyme (AAE) consensus motif; other site 1112204003042 AMP binding site [chemical binding]; other site 1112204003043 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204003044 Predicted esterase [General function prediction only]; Region: COG0627 1112204003045 S-formylglutathione hydrolase; Region: PLN02442 1112204003046 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204003047 active site 1112204003048 CoA binding site [chemical binding]; other site 1112204003049 AMP binding site [chemical binding]; other site 1112204003050 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1112204003051 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1112204003052 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1112204003053 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1112204003054 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204003055 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1112204003056 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1112204003057 active site 1112204003058 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1112204003059 O-Antigen ligase; Region: Wzy_C; pfam04932 1112204003060 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1112204003061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204003062 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1112204003063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204003064 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1112204003065 putative ADP-binding pocket [chemical binding]; other site 1112204003066 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1112204003067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204003068 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1112204003069 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1112204003070 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1112204003071 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1112204003072 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1112204003073 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1112204003074 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1112204003075 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1112204003076 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1112204003077 active site 1112204003078 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1112204003079 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1112204003080 extended (e) SDRs; Region: SDR_e; cd08946 1112204003081 NAD(P) binding site [chemical binding]; other site 1112204003082 active site 1112204003083 substrate binding site [chemical binding]; other site 1112204003084 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1112204003085 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1112204003086 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1112204003087 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204003088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204003089 catalytic residue [active] 1112204003090 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1112204003091 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1112204003092 ATP binding site [chemical binding]; other site 1112204003093 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1112204003094 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1112204003095 metal binding site [ion binding]; metal-binding site 1112204003096 active site 1112204003097 I-site; other site 1112204003098 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1112204003099 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1112204003100 putative active site [active] 1112204003101 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204003102 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1112204003103 substrate binding site [chemical binding]; other site 1112204003104 oxyanion hole (OAH) forming residues; other site 1112204003105 trimer interface [polypeptide binding]; other site 1112204003106 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204003107 CoenzymeA binding site [chemical binding]; other site 1112204003108 subunit interaction site [polypeptide binding]; other site 1112204003109 PHB binding site; other site 1112204003110 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1112204003111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204003112 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1112204003113 S-adenosylmethionine binding site [chemical binding]; other site 1112204003114 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1112204003115 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1112204003116 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1112204003117 PYR/PP interface [polypeptide binding]; other site 1112204003118 dimer interface [polypeptide binding]; other site 1112204003119 TPP binding site [chemical binding]; other site 1112204003120 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1112204003121 TPP-binding site; other site 1112204003122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204003123 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1112204003124 putative methyltransferase; Provisional; Region: PRK14967 1112204003125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204003126 S-adenosylmethionine binding site [chemical binding]; other site 1112204003127 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1112204003128 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1112204003129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204003130 S-adenosylmethionine binding site [chemical binding]; other site 1112204003131 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204003132 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1112204003133 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1112204003134 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1112204003135 substrate binding pocket [chemical binding]; other site 1112204003136 chain length determination region; other site 1112204003137 substrate-Mg2+ binding site; other site 1112204003138 catalytic residues [active] 1112204003139 aspartate-rich region 1; other site 1112204003140 active site lid residues [active] 1112204003141 aspartate-rich region 2; other site 1112204003142 heat shock protein HtpX; Provisional; Region: PRK03072 1112204003143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1112204003144 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1112204003145 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1112204003146 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1112204003147 active site 1112204003148 catalytic site [active] 1112204003149 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204003150 active site 2 [active] 1112204003151 active site 1 [active] 1112204003152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204003153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204003154 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1112204003155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204003156 DNA-binding site [nucleotide binding]; DNA binding site 1112204003157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204003158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204003159 homodimer interface [polypeptide binding]; other site 1112204003160 catalytic residue [active] 1112204003161 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1112204003162 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1112204003163 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1112204003164 putative homodimer interface [polypeptide binding]; other site 1112204003165 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1112204003166 heterodimer interface [polypeptide binding]; other site 1112204003167 homodimer interface [polypeptide binding]; other site 1112204003168 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1112204003169 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1112204003170 23S rRNA interface [nucleotide binding]; other site 1112204003171 L7/L12 interface [polypeptide binding]; other site 1112204003172 putative thiostrepton binding site; other site 1112204003173 L25 interface [polypeptide binding]; other site 1112204003174 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1112204003175 mRNA/rRNA interface [nucleotide binding]; other site 1112204003176 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1112204003177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204003178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204003179 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1112204003180 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204003181 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1112204003182 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204003183 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 1112204003184 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1112204003185 dimer interface [polypeptide binding]; other site 1112204003186 PYR/PP interface [polypeptide binding]; other site 1112204003187 TPP binding site [chemical binding]; other site 1112204003188 substrate binding site [chemical binding]; other site 1112204003189 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1112204003190 TPP-binding site [chemical binding]; other site 1112204003191 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1112204003192 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1112204003193 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1112204003194 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1112204003195 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204003196 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1112204003197 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1112204003198 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1112204003199 carboxyltransferase (CT) interaction site; other site 1112204003200 biotinylation site [posttranslational modification]; other site 1112204003201 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204003202 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204003203 active site 1112204003204 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1112204003205 putative active site [active] 1112204003206 putative catalytic site [active] 1112204003207 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1112204003208 AMP-binding domain protein; Validated; Region: PRK08315 1112204003209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204003210 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1112204003211 acyl-activating enzyme (AAE) consensus motif; other site 1112204003212 putative AMP binding site [chemical binding]; other site 1112204003213 putative active site [active] 1112204003214 putative CoA binding site [chemical binding]; other site 1112204003215 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1112204003216 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204003217 acyl-activating enzyme (AAE) consensus motif; other site 1112204003218 AMP binding site [chemical binding]; other site 1112204003219 active site 1112204003220 CoA binding site [chemical binding]; other site 1112204003221 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1112204003222 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1112204003223 active site 1112204003224 substrate binding site [chemical binding]; other site 1112204003225 cosubstrate binding site; other site 1112204003226 catalytic site [active] 1112204003227 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1112204003228 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1112204003229 purine monophosphate binding site [chemical binding]; other site 1112204003230 dimer interface [polypeptide binding]; other site 1112204003231 putative catalytic residues [active] 1112204003232 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1112204003233 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1112204003234 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1112204003235 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1112204003236 L-aspartate oxidase; Provisional; Region: PRK06175 1112204003237 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1112204003238 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1112204003239 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1112204003240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204003241 DNA-binding site [nucleotide binding]; DNA binding site 1112204003242 UTRA domain; Region: UTRA; pfam07702 1112204003243 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1112204003244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1112204003245 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1112204003246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1112204003247 substrate binding pocket [chemical binding]; other site 1112204003248 membrane-bound complex binding site; other site 1112204003249 hinge residues; other site 1112204003250 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1112204003251 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1112204003252 Walker A/P-loop; other site 1112204003253 ATP binding site [chemical binding]; other site 1112204003254 Q-loop/lid; other site 1112204003255 ABC transporter signature motif; other site 1112204003256 Walker B; other site 1112204003257 D-loop; other site 1112204003258 H-loop/switch region; other site 1112204003259 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1112204003260 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1112204003261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204003262 dimerization interface [polypeptide binding]; other site 1112204003263 putative DNA binding site [nucleotide binding]; other site 1112204003264 putative Zn2+ binding site [ion binding]; other site 1112204003265 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1112204003266 putative hydrophobic ligand binding site [chemical binding]; other site 1112204003267 TIGR03086 family protein; Region: TIGR03086 1112204003268 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1112204003269 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1112204003270 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1112204003271 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1112204003272 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1112204003273 metal ion-dependent adhesion site (MIDAS); other site 1112204003274 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1112204003275 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1112204003276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204003277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204003278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003279 Predicted permeases [General function prediction only]; Region: COG0679 1112204003280 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1112204003281 Predicted membrane protein [Function unknown]; Region: COG2860 1112204003282 UPF0126 domain; Region: UPF0126; pfam03458 1112204003283 UPF0126 domain; Region: UPF0126; pfam03458 1112204003284 short chain dehydrogenase; Provisional; Region: PRK08267 1112204003285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204003286 NAD(P) binding site [chemical binding]; other site 1112204003287 active site 1112204003288 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1112204003289 ferredoxin-NADP+ reductase; Region: PLN02852 1112204003290 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1112204003291 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1112204003292 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1112204003293 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1112204003294 iron-sulfur cluster [ion binding]; other site 1112204003295 [2Fe-2S] cluster binding site [ion binding]; other site 1112204003296 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1112204003297 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1112204003298 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1112204003299 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1112204003300 [4Fe-4S] binding site [ion binding]; other site 1112204003301 molybdopterin cofactor binding site; other site 1112204003302 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1112204003303 molybdopterin cofactor binding site; other site 1112204003304 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1112204003305 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1112204003306 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1112204003307 FAD binding pocket [chemical binding]; other site 1112204003308 FAD binding motif [chemical binding]; other site 1112204003309 catalytic residues [active] 1112204003310 NAD binding pocket [chemical binding]; other site 1112204003311 phosphate binding motif [ion binding]; other site 1112204003312 beta-alpha-beta structure motif; other site 1112204003313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204003314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204003315 active site 1112204003316 phosphorylation site [posttranslational modification] 1112204003317 intermolecular recognition site; other site 1112204003318 dimerization interface [polypeptide binding]; other site 1112204003319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204003320 DNA binding site [nucleotide binding] 1112204003321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1112204003322 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204003323 dimerization interface [polypeptide binding]; other site 1112204003324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204003325 dimer interface [polypeptide binding]; other site 1112204003326 phosphorylation site [posttranslational modification] 1112204003327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204003328 ATP binding site [chemical binding]; other site 1112204003329 Mg2+ binding site [ion binding]; other site 1112204003330 G-X-G motif; other site 1112204003331 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1112204003332 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1112204003333 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1112204003334 protein binding site [polypeptide binding]; other site 1112204003335 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1112204003336 MPT binding site; other site 1112204003337 trimer interface [polypeptide binding]; other site 1112204003338 MspA; Region: MspA; pfam09203 1112204003339 MspA; Region: MspA; pfam09203 1112204003340 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1112204003341 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1112204003342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204003343 active site 1112204003344 motif I; other site 1112204003345 motif II; other site 1112204003346 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1112204003347 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1112204003348 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1112204003349 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1112204003350 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1112204003351 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1112204003352 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1112204003353 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1112204003354 active site 1112204003355 tetramer interface; other site 1112204003356 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1112204003357 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1112204003358 dimer interface [polypeptide binding]; other site 1112204003359 putative functional site; other site 1112204003360 putative MPT binding site; other site 1112204003361 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1112204003362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1112204003363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1112204003364 Histidine kinase; Region: HisKA_3; pfam07730 1112204003365 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1112204003366 ATP binding site [chemical binding]; other site 1112204003367 Mg2+ binding site [ion binding]; other site 1112204003368 G-X-G motif; other site 1112204003369 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204003370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204003371 active site 1112204003372 phosphorylation site [posttranslational modification] 1112204003373 intermolecular recognition site; other site 1112204003374 dimerization interface [polypeptide binding]; other site 1112204003375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204003376 DNA binding residues [nucleotide binding] 1112204003377 dimerization interface [polypeptide binding]; other site 1112204003378 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1112204003379 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1112204003380 putative transposase OrfB; Reviewed; Region: PHA02517 1112204003381 HTH-like domain; Region: HTH_21; pfam13276 1112204003382 Integrase core domain; Region: rve; pfam00665 1112204003383 Integrase core domain; Region: rve_3; pfam13683 1112204003384 LGFP repeat; Region: LGFP; pfam08310 1112204003385 HTH-like domain; Region: HTH_21; pfam13276 1112204003386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1112204003387 Integrase core domain; Region: rve; pfam00665 1112204003388 Integrase core domain; Region: rve_3; pfam13683 1112204003389 Lsr2; Region: Lsr2; pfam11774 1112204003390 putative transposase OrfB; Reviewed; Region: PHA02517 1112204003391 HTH-like domain; Region: HTH_21; pfam13276 1112204003392 Integrase core domain; Region: rve; pfam00665 1112204003393 Integrase core domain; Region: rve_3; pfam13683 1112204003394 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204003395 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1112204003396 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1112204003397 Winged helix-turn helix; Region: HTH_29; pfam13551 1112204003398 Homeodomain-like domain; Region: HTH_32; pfam13565 1112204003399 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1112204003400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204003401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204003402 DNA binding residues [nucleotide binding] 1112204003403 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204003404 DNA binding site [nucleotide binding] 1112204003405 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1112204003406 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204003407 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1112204003408 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1112204003409 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1112204003410 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1112204003411 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204003412 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204003413 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1112204003414 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204003415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204003417 putative substrate translocation pore; other site 1112204003418 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204003419 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204003420 AsnC family; Region: AsnC_trans_reg; pfam01037 1112204003421 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204003422 MarR family; Region: MarR; pfam01047 1112204003423 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1112204003424 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1112204003425 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1112204003426 putative di-iron ligands [ion binding]; other site 1112204003427 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1112204003428 DNA-binding site [nucleotide binding]; DNA binding site 1112204003429 RNA-binding motif; other site 1112204003430 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1112204003431 Lipase (class 2); Region: Lipase_2; pfam01674 1112204003432 AzlC protein; Region: AzlC; pfam03591 1112204003433 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204003434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204003435 non-specific DNA binding site [nucleotide binding]; other site 1112204003436 salt bridge; other site 1112204003437 sequence-specific DNA binding site [nucleotide binding]; other site 1112204003438 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1112204003439 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1112204003440 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1112204003441 4Fe-4S binding domain; Region: Fer4; pfam00037 1112204003442 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1112204003443 ferredoxin-NADP+ reductase; Region: PLN02852 1112204003444 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204003445 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1112204003446 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1112204003447 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1112204003448 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1112204003449 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1112204003450 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1112204003451 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1112204003452 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1112204003453 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1112204003454 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1112204003455 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1112204003456 phosphopeptide binding site; other site 1112204003457 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1112204003458 Protein kinase domain; Region: Pkinase; pfam00069 1112204003459 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204003460 active site 1112204003461 ATP binding site [chemical binding]; other site 1112204003462 substrate binding site [chemical binding]; other site 1112204003463 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204003464 activation loop (A-loop); other site 1112204003465 activation loop (A-loop); other site 1112204003466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204003467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204003468 active site 1112204003469 ATP binding site [chemical binding]; other site 1112204003470 substrate binding site [chemical binding]; other site 1112204003471 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204003472 substrate binding site [chemical binding]; other site 1112204003473 activation loop (A-loop); other site 1112204003474 activation loop (A-loop); other site 1112204003475 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204003476 Ligand Binding Site [chemical binding]; other site 1112204003477 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204003478 Ligand Binding Site [chemical binding]; other site 1112204003479 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1112204003480 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1112204003481 DNA binding residues [nucleotide binding] 1112204003482 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1112204003483 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1112204003484 active site 1112204003485 nucleophile elbow; other site 1112204003486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204003488 putative substrate translocation pore; other site 1112204003489 Amidinotransferase; Region: Amidinotransf; cl12043 1112204003490 Predicted transcriptional regulators [Transcription]; Region: COG1725 1112204003491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204003492 DNA-binding site [nucleotide binding]; DNA binding site 1112204003493 BCCT family transporter; Region: BCCT; pfam02028 1112204003494 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1112204003495 Predicted methyltransferases [General function prediction only]; Region: COG0313 1112204003496 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1112204003497 putative SAM binding site [chemical binding]; other site 1112204003498 putative homodimer interface [polypeptide binding]; other site 1112204003499 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1112204003500 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1112204003501 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1112204003502 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1112204003503 active site 1112204003504 HIGH motif; other site 1112204003505 KMSKS motif; other site 1112204003506 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1112204003507 tRNA binding surface [nucleotide binding]; other site 1112204003508 anticodon binding site; other site 1112204003509 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1112204003510 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204003511 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1112204003512 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204003513 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1112204003514 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1112204003515 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1112204003516 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1112204003517 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1112204003518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204003519 motif II; other site 1112204003520 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1112204003521 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1112204003522 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1112204003523 active site 1112204003524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1112204003525 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1112204003526 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1112204003527 G5 domain; Region: G5; pfam07501 1112204003528 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1112204003529 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1112204003530 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1112204003531 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1112204003532 Part of AAA domain; Region: AAA_19; pfam13245 1112204003533 Family description; Region: UvrD_C_2; pfam13538 1112204003534 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204003535 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1112204003536 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1112204003537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1112204003538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204003539 motif II; other site 1112204003540 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1112204003541 Secretory lipase; Region: LIP; pfam03583 1112204003542 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204003543 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1112204003544 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204003545 ABC transporter; Region: ABC_tran_2; pfam12848 1112204003546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204003547 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204003548 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1112204003549 catalytic site [active] 1112204003550 Carbon starvation protein CstA; Region: CstA; pfam02554 1112204003551 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1112204003552 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1112204003553 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1112204003554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204003555 Walker A/P-loop; other site 1112204003556 ATP binding site [chemical binding]; other site 1112204003557 Q-loop/lid; other site 1112204003558 ABC transporter signature motif; other site 1112204003559 Walker B; other site 1112204003560 D-loop; other site 1112204003561 H-loop/switch region; other site 1112204003562 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1112204003563 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204003564 EamA-like transporter family; Region: EamA; pfam00892 1112204003565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204003566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204003567 dimerization interface [polypeptide binding]; other site 1112204003568 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1112204003569 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204003570 substrate binding site [chemical binding]; other site 1112204003571 oxyanion hole (OAH) forming residues; other site 1112204003572 trimer interface [polypeptide binding]; other site 1112204003573 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1112204003574 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204003575 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204003576 active site 1112204003577 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1112204003578 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1112204003579 G1 box; other site 1112204003580 putative GEF interaction site [polypeptide binding]; other site 1112204003581 GTP/Mg2+ binding site [chemical binding]; other site 1112204003582 Switch I region; other site 1112204003583 G2 box; other site 1112204003584 G3 box; other site 1112204003585 Switch II region; other site 1112204003586 G4 box; other site 1112204003587 G5 box; other site 1112204003588 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1112204003589 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1112204003590 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1112204003591 dimer interface [polypeptide binding]; other site 1112204003592 active site 1112204003593 CoA binding pocket [chemical binding]; other site 1112204003594 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1112204003595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204003596 Walker A/P-loop; other site 1112204003597 ATP binding site [chemical binding]; other site 1112204003598 Q-loop/lid; other site 1112204003599 ABC transporter signature motif; other site 1112204003600 Walker B; other site 1112204003601 D-loop; other site 1112204003602 H-loop/switch region; other site 1112204003603 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1112204003604 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204003605 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1112204003606 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1112204003607 dimer interface [polypeptide binding]; other site 1112204003608 active site 1112204003609 CoA binding pocket [chemical binding]; other site 1112204003610 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1112204003611 putative active site [active] 1112204003612 catalytic residue [active] 1112204003613 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1112204003614 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1112204003615 5S rRNA interface [nucleotide binding]; other site 1112204003616 CTC domain interface [polypeptide binding]; other site 1112204003617 L16 interface [polypeptide binding]; other site 1112204003618 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1112204003619 TM2 domain; Region: TM2; pfam05154 1112204003620 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1112204003621 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1112204003622 active site 1112204003623 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1112204003624 dimer interface [polypeptide binding]; other site 1112204003625 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1112204003626 Ligand Binding Site [chemical binding]; other site 1112204003627 Molecular Tunnel; other site 1112204003628 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1112204003629 ArsC family; Region: ArsC; pfam03960 1112204003630 catalytic residues [active] 1112204003631 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1112204003632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003633 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1112204003634 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1112204003635 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1112204003636 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204003637 active site 1112204003638 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1112204003639 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1112204003640 Substrate binding site; other site 1112204003641 Mg++ binding site; other site 1112204003642 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1112204003643 active site 1112204003644 substrate binding site [chemical binding]; other site 1112204003645 CoA binding site [chemical binding]; other site 1112204003646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204003647 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204003648 NAD(P) binding site [chemical binding]; other site 1112204003649 active site 1112204003650 Transposase; Region: HTH_Tnp_1; cl17663 1112204003651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1112204003652 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1112204003653 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1112204003654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204003655 S-adenosylmethionine binding site [chemical binding]; other site 1112204003656 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1112204003657 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1112204003658 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1112204003659 iron-sulfur cluster [ion binding]; other site 1112204003660 [2Fe-2S] cluster binding site [ion binding]; other site 1112204003661 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1112204003662 alpha subunit interface [polypeptide binding]; other site 1112204003663 active site 1112204003664 substrate binding site [chemical binding]; other site 1112204003665 Fe binding site [ion binding]; other site 1112204003666 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1112204003667 FMN-binding pocket [chemical binding]; other site 1112204003668 flavin binding motif; other site 1112204003669 phosphate binding motif [ion binding]; other site 1112204003670 beta-alpha-beta structure motif; other site 1112204003671 NAD binding pocket [chemical binding]; other site 1112204003672 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204003673 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1112204003674 catalytic loop [active] 1112204003675 iron binding site [ion binding]; other site 1112204003676 benzoate transport; Region: 2A0115; TIGR00895 1112204003677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003678 putative substrate translocation pore; other site 1112204003679 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1112204003680 malate:quinone oxidoreductase; Validated; Region: PRK05257 1112204003681 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1112204003682 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1112204003683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204003684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204003685 dimerization interface [polypeptide binding]; other site 1112204003686 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1112204003687 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1112204003688 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1112204003689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204003690 dimer interface [polypeptide binding]; other site 1112204003691 conserved gate region; other site 1112204003692 putative PBP binding loops; other site 1112204003693 ABC-ATPase subunit interface; other site 1112204003694 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1112204003695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204003696 dimer interface [polypeptide binding]; other site 1112204003697 conserved gate region; other site 1112204003698 putative PBP binding loops; other site 1112204003699 ABC-ATPase subunit interface; other site 1112204003700 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1112204003701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204003702 Walker A/P-loop; other site 1112204003703 ATP binding site [chemical binding]; other site 1112204003704 Q-loop/lid; other site 1112204003705 ABC transporter signature motif; other site 1112204003706 Walker B; other site 1112204003707 D-loop; other site 1112204003708 H-loop/switch region; other site 1112204003709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1112204003710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204003711 Walker A/P-loop; other site 1112204003712 ATP binding site [chemical binding]; other site 1112204003713 Q-loop/lid; other site 1112204003714 ABC transporter signature motif; other site 1112204003715 Walker B; other site 1112204003716 D-loop; other site 1112204003717 H-loop/switch region; other site 1112204003718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1112204003719 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1112204003720 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1112204003721 putative hydrophobic ligand binding site [chemical binding]; other site 1112204003722 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204003723 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204003724 active site 1112204003725 ATP binding site [chemical binding]; other site 1112204003726 substrate binding site [chemical binding]; other site 1112204003727 activation loop (A-loop); other site 1112204003728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003729 putative substrate translocation pore; other site 1112204003730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204003731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204003732 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1112204003733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204003734 dimer interface [polypeptide binding]; other site 1112204003735 conserved gate region; other site 1112204003736 putative PBP binding loops; other site 1112204003737 ABC-ATPase subunit interface; other site 1112204003738 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1112204003739 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1112204003740 Walker A/P-loop; other site 1112204003741 ATP binding site [chemical binding]; other site 1112204003742 Q-loop/lid; other site 1112204003743 ABC transporter signature motif; other site 1112204003744 Walker B; other site 1112204003745 D-loop; other site 1112204003746 H-loop/switch region; other site 1112204003747 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1112204003748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204003749 putative PBP binding loops; other site 1112204003750 dimer interface [polypeptide binding]; other site 1112204003751 ABC-ATPase subunit interface; other site 1112204003752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204003753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204003754 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1112204003755 putative active site [active] 1112204003756 metal binding site [ion binding]; metal-binding site 1112204003757 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1112204003758 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1112204003759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204003760 ATP binding site [chemical binding]; other site 1112204003761 putative Mg++ binding site [ion binding]; other site 1112204003762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204003763 nucleotide binding region [chemical binding]; other site 1112204003764 ATP-binding site [chemical binding]; other site 1112204003765 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1112204003766 Peptidase family M48; Region: Peptidase_M48; pfam01435 1112204003767 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1112204003768 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1112204003769 homodimer interface [polypeptide binding]; other site 1112204003770 metal binding site [ion binding]; metal-binding site 1112204003771 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1112204003772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204003773 DNA-binding site [nucleotide binding]; DNA binding site 1112204003774 UTRA domain; Region: UTRA; pfam07702 1112204003775 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1112204003776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204003777 motif II; other site 1112204003778 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1112204003779 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1112204003780 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204003781 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204003782 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204003783 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1112204003784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204003785 DNA-binding site [nucleotide binding]; DNA binding site 1112204003786 FCD domain; Region: FCD; pfam07729 1112204003787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204003789 putative substrate translocation pore; other site 1112204003790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204003791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204003792 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1112204003793 dimerization interface [polypeptide binding]; other site 1112204003794 substrate binding pocket [chemical binding]; other site 1112204003795 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204003796 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204003797 Cupin domain; Region: Cupin_2; cl17218 1112204003798 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1112204003799 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1112204003800 Sulfatase; Region: Sulfatase; pfam00884 1112204003801 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 1112204003802 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1112204003803 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1112204003804 Active Sites [active] 1112204003805 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1112204003806 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1112204003807 CysD dimerization site [polypeptide binding]; other site 1112204003808 G1 box; other site 1112204003809 putative GEF interaction site [polypeptide binding]; other site 1112204003810 GTP/Mg2+ binding site [chemical binding]; other site 1112204003811 Switch I region; other site 1112204003812 G2 box; other site 1112204003813 G3 box; other site 1112204003814 Switch II region; other site 1112204003815 G4 box; other site 1112204003816 G5 box; other site 1112204003817 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1112204003818 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1112204003819 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1112204003820 ligand-binding site [chemical binding]; other site 1112204003821 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1112204003822 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1112204003823 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1112204003824 Imelysin; Region: Peptidase_M75; pfam09375 1112204003825 Iron permease FTR1 family; Region: FTR1; cl00475 1112204003826 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1112204003827 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1112204003828 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1112204003829 enolase; Provisional; Region: eno; PRK00077 1112204003830 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1112204003831 dimer interface [polypeptide binding]; other site 1112204003832 metal binding site [ion binding]; metal-binding site 1112204003833 substrate binding pocket [chemical binding]; other site 1112204003834 Septum formation initiator; Region: DivIC; pfam04977 1112204003835 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1112204003836 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1112204003837 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1112204003838 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1112204003839 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1112204003840 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1112204003841 putative di-iron ligands [ion binding]; other site 1112204003842 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1112204003843 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204003844 FAD binding pocket [chemical binding]; other site 1112204003845 FAD binding motif [chemical binding]; other site 1112204003846 phosphate binding motif [ion binding]; other site 1112204003847 beta-alpha-beta structure motif; other site 1112204003848 NAD binding pocket [chemical binding]; other site 1112204003849 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1112204003850 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204003851 catalytic loop [active] 1112204003852 iron binding site [ion binding]; other site 1112204003853 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1112204003854 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204003855 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204003856 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1112204003857 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 1112204003858 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1112204003859 carboxyltransferase (CT) interaction site; other site 1112204003860 biotinylation site [posttranslational modification]; other site 1112204003861 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1112204003862 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1112204003863 oxyanion hole (OAH) forming residues; other site 1112204003864 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1112204003865 classical (c) SDRs; Region: SDR_c; cd05233 1112204003866 NAD(P) binding site [chemical binding]; other site 1112204003867 active site 1112204003868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204003869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204003870 active site 1112204003871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204003872 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204003873 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1112204003874 active site 1112204003875 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1112204003876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204003877 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1112204003878 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1112204003879 active site 1112204003880 dimer interface [polypeptide binding]; other site 1112204003881 non-prolyl cis peptide bond; other site 1112204003882 insertion regions; other site 1112204003883 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204003884 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204003885 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1112204003886 active site 1112204003887 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204003888 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204003889 active site 1112204003890 ATP binding site [chemical binding]; other site 1112204003891 substrate binding site [chemical binding]; other site 1112204003892 activation loop (A-loop); other site 1112204003893 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1112204003894 YibE/F-like protein; Region: YibE_F; pfam07907 1112204003895 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1112204003896 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204003897 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204003898 DinB superfamily; Region: DinB_2; pfam12867 1112204003899 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1112204003900 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204003901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204003902 active site 1112204003903 phosphorylation site [posttranslational modification] 1112204003904 intermolecular recognition site; other site 1112204003905 dimerization interface [polypeptide binding]; other site 1112204003906 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204003907 DNA binding residues [nucleotide binding] 1112204003908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1112204003909 Histidine kinase; Region: HisKA_3; pfam07730 1112204003910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204003911 ATP binding site [chemical binding]; other site 1112204003912 Mg2+ binding site [ion binding]; other site 1112204003913 G-X-G motif; other site 1112204003914 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1112204003915 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1112204003916 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1112204003917 Walker A/P-loop; other site 1112204003918 ATP binding site [chemical binding]; other site 1112204003919 Q-loop/lid; other site 1112204003920 ABC transporter signature motif; other site 1112204003921 Walker B; other site 1112204003922 D-loop; other site 1112204003923 H-loop/switch region; other site 1112204003924 Amino acid permease; Region: AA_permease_2; pfam13520 1112204003925 MspA; Region: MspA; pfam09203 1112204003926 MspA; Region: MspA; pfam09203 1112204003927 Cation efflux family; Region: Cation_efflux; cl00316 1112204003928 Pirin-related protein [General function prediction only]; Region: COG1741 1112204003929 Pirin; Region: Pirin; pfam02678 1112204003930 MarR family; Region: MarR_2; pfam12802 1112204003931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204003932 MarR family; Region: MarR_2; cl17246 1112204003933 Pirin-related protein [General function prediction only]; Region: COG1741 1112204003934 Pirin; Region: Pirin; pfam02678 1112204003935 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1112204003936 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204003937 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1112204003938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1112204003939 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1112204003940 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1112204003941 TIGR03086 family protein; Region: TIGR03086 1112204003942 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1112204003943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1112204003944 HTH domain; Region: HTH_11; pfam08279 1112204003945 WYL domain; Region: WYL; pfam13280 1112204003946 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 1112204003947 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1112204003948 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204003949 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1112204003950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204003951 S-adenosylmethionine binding site [chemical binding]; other site 1112204003952 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1112204003953 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204003954 NAD binding site [chemical binding]; other site 1112204003955 catalytic residues [active] 1112204003956 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1112204003957 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1112204003958 Helix-turn-helix domain; Region: HTH_38; pfam13936 1112204003959 Integrase core domain; Region: rve; pfam00665 1112204003960 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1112204003961 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1112204003962 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1112204003963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204003964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1112204003965 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1112204003966 ATP binding site [chemical binding]; other site 1112204003967 putative Mg++ binding site [ion binding]; other site 1112204003968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204003969 nucleotide binding region [chemical binding]; other site 1112204003970 ATP-binding site [chemical binding]; other site 1112204003971 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1112204003972 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1112204003973 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1112204003974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204003975 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1112204003976 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1112204003977 MarR family; Region: MarR_2; pfam12802 1112204003978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003979 putative substrate translocation pore; other site 1112204003980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204003981 putative substrate translocation pore; other site 1112204003982 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1112204003983 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1112204003984 Cl- selectivity filter; other site 1112204003985 Cl- binding residues [ion binding]; other site 1112204003986 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1112204003987 pore gating glutamate residue; other site 1112204003988 dimer interface [polypeptide binding]; other site 1112204003989 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1112204003990 4Fe-4S binding domain; Region: Fer4; cl02805 1112204003991 ferredoxin-NADP+ reductase; Region: PLN02852 1112204003992 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1112204003993 cyanate hydratase; Validated; Region: PRK02866 1112204003994 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1112204003995 oligomer interface [polypeptide binding]; other site 1112204003996 active site 1112204003997 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1112204003998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204003999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204004000 WHG domain; Region: WHG; pfam13305 1112204004001 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1112204004002 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1112204004003 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1112204004004 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204004005 dimer interface [polypeptide binding]; other site 1112204004006 active site 1112204004007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204004008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204004009 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1112204004010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204004011 putative substrate translocation pore; other site 1112204004012 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1112204004013 active site 1112204004014 catalytic triad [active] 1112204004015 oxyanion hole [active] 1112204004016 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1112204004017 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1112204004018 dimer interface [polypeptide binding]; other site 1112204004019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204004020 catalytic residue [active] 1112204004021 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1112204004022 cystathionine gamma-synthase; Provisional; Region: PRK07811 1112204004023 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1112204004024 homodimer interface [polypeptide binding]; other site 1112204004025 substrate-cofactor binding pocket; other site 1112204004026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204004027 catalytic residue [active] 1112204004028 threonine dehydratase; Provisional; Region: PRK08198 1112204004029 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1112204004030 tetramer interface [polypeptide binding]; other site 1112204004031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204004032 catalytic residue [active] 1112204004033 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1112204004034 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1112204004035 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1112204004036 DNA binding site [nucleotide binding] 1112204004037 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1112204004038 AAA ATPase domain; Region: AAA_16; pfam13191 1112204004039 Predicted ATPase [General function prediction only]; Region: COG3903 1112204004040 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204004041 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1112204004042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204004043 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1112204004044 Walker A/P-loop; other site 1112204004045 ATP binding site [chemical binding]; other site 1112204004046 Q-loop/lid; other site 1112204004047 ABC transporter signature motif; other site 1112204004048 Walker B; other site 1112204004049 D-loop; other site 1112204004050 H-loop/switch region; other site 1112204004051 short chain dehydrogenase; Provisional; Region: PRK06180 1112204004052 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1112204004053 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1112204004054 active site 1112204004055 catalytic triad [active] 1112204004056 oxyanion hole [active] 1112204004057 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1112204004058 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1112204004059 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1112204004060 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1112204004061 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1112204004062 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1112204004063 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1112204004064 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1112204004065 catalytic residues [active] 1112204004066 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1112204004067 Patatin-like phospholipase; Region: Patatin; pfam01734 1112204004068 nucleophile elbow; other site 1112204004069 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204004070 catalytic core [active] 1112204004071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204004072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204004073 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1112204004074 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1112204004075 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1112204004076 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1112204004077 YCII-related domain; Region: YCII; cl00999 1112204004078 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1112204004079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204004080 DNA binding residues [nucleotide binding] 1112204004081 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1112204004082 Amidinotransferase; Region: Amidinotransf; pfam02274 1112204004083 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204004084 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1112204004085 inhibitor-cofactor binding pocket; inhibition site 1112204004086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204004087 catalytic residue [active] 1112204004088 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1112204004089 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1112204004090 putative DNA binding site [nucleotide binding]; other site 1112204004091 putative Zn2+ binding site [ion binding]; other site 1112204004092 AsnC family; Region: AsnC_trans_reg; pfam01037 1112204004093 Putative esterase; Region: Esterase; pfam00756 1112204004094 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1112204004095 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1112204004096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1112204004097 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1112204004098 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1112204004099 oligomer interface [polypeptide binding]; other site 1112204004100 active site residues [active] 1112204004101 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1112204004102 active site residues [active] 1112204004103 PhoD-like phosphatase; Region: PhoD; pfam09423 1112204004104 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1112204004105 putative active site [active] 1112204004106 putative metal binding site [ion binding]; other site 1112204004107 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1112204004108 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1112204004109 ABC-ATPase subunit interface; other site 1112204004110 dimer interface [polypeptide binding]; other site 1112204004111 putative PBP binding regions; other site 1112204004112 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1112204004113 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1112204004114 Walker A/P-loop; other site 1112204004115 ATP binding site [chemical binding]; other site 1112204004116 Q-loop/lid; other site 1112204004117 ABC transporter signature motif; other site 1112204004118 Walker B; other site 1112204004119 D-loop; other site 1112204004120 H-loop/switch region; other site 1112204004121 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1112204004122 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1112204004123 putative ligand binding residues [chemical binding]; other site 1112204004124 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1112204004125 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1112204004126 putative ligand binding residues [chemical binding]; other site 1112204004127 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1112204004128 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1112204004129 ABC-ATPase subunit interface; other site 1112204004130 dimer interface [polypeptide binding]; other site 1112204004131 putative PBP binding regions; other site 1112204004132 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1112204004133 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1112204004134 Walker A/P-loop; other site 1112204004135 ATP binding site [chemical binding]; other site 1112204004136 Q-loop/lid; other site 1112204004137 ABC transporter signature motif; other site 1112204004138 Walker B; other site 1112204004139 D-loop; other site 1112204004140 H-loop/switch region; other site 1112204004141 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1112204004142 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1112204004143 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1112204004144 catalytic residue [active] 1112204004145 putative FPP diphosphate binding site; other site 1112204004146 putative FPP binding hydrophobic cleft; other site 1112204004147 dimer interface [polypeptide binding]; other site 1112204004148 putative IPP diphosphate binding site; other site 1112204004149 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1112204004150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204004151 DNA-binding site [nucleotide binding]; DNA binding site 1112204004152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204004153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204004154 homodimer interface [polypeptide binding]; other site 1112204004155 catalytic residue [active] 1112204004156 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1112204004157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204004158 NAD(P) binding site [chemical binding]; other site 1112204004159 active site 1112204004160 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1112204004161 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1112204004162 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1112204004163 MarR family; Region: MarR_2; pfam12802 1112204004164 MarR family; Region: MarR_2; cl17246 1112204004165 Cupin domain; Region: Cupin_2; pfam07883 1112204004166 pantothenate kinase; Provisional; Region: PRK05439 1112204004167 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1112204004168 ATP-binding site [chemical binding]; other site 1112204004169 CoA-binding site [chemical binding]; other site 1112204004170 Mg2+-binding site [ion binding]; other site 1112204004171 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1112204004172 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1112204004173 dimer interface [polypeptide binding]; other site 1112204004174 active site 1112204004175 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1112204004176 folate binding site [chemical binding]; other site 1112204004177 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1112204004178 dinuclear metal binding motif [ion binding]; other site 1112204004179 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1112204004180 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1112204004181 putative active site [active] 1112204004182 PhoH-like protein; Region: PhoH; pfam02562 1112204004183 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1112204004184 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1112204004185 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1112204004186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204004187 Walker A/P-loop; other site 1112204004188 ATP binding site [chemical binding]; other site 1112204004189 Q-loop/lid; other site 1112204004190 ABC transporter signature motif; other site 1112204004191 Walker B; other site 1112204004192 D-loop; other site 1112204004193 H-loop/switch region; other site 1112204004194 TOBE domain; Region: TOBE_2; pfam08402 1112204004195 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1112204004196 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1112204004197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204004198 dimer interface [polypeptide binding]; other site 1112204004199 conserved gate region; other site 1112204004200 putative PBP binding loops; other site 1112204004201 ABC-ATPase subunit interface; other site 1112204004202 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1112204004203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1112204004204 classical (c) SDRs; Region: SDR_c; cd05233 1112204004205 NAD(P) binding site [chemical binding]; other site 1112204004206 active site 1112204004207 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204004208 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204004209 active site 1112204004210 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204004211 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1112204004212 putative active site [active] 1112204004213 putative substrate binding site [chemical binding]; other site 1112204004214 ATP binding site [chemical binding]; other site 1112204004215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204004216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204004217 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204004218 mce related protein; Region: MCE; pfam02470 1112204004219 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1112204004220 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1112204004221 acyl-activating enzyme (AAE) consensus motif; other site 1112204004222 putative AMP binding site [chemical binding]; other site 1112204004223 putative active site [active] 1112204004224 putative CoA binding site [chemical binding]; other site 1112204004225 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1112204004226 active site 1112204004227 substrate binding pocket [chemical binding]; other site 1112204004228 homodimer interaction site [polypeptide binding]; other site 1112204004229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1112204004230 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1112204004231 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1112204004232 Class II fumarases; Region: Fumarase_classII; cd01362 1112204004233 active site 1112204004234 tetramer interface [polypeptide binding]; other site 1112204004235 fumarate hydratase; Provisional; Region: PRK15389 1112204004236 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1112204004237 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1112204004238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204004239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204004240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204004241 dimerization interface [polypeptide binding]; other site 1112204004242 SnoaL-like domain; Region: SnoaL_2; pfam12680 1112204004243 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1112204004244 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1112204004245 putative active site [active] 1112204004246 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1112204004247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204004248 Coenzyme A binding pocket [chemical binding]; other site 1112204004249 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1112204004250 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1112204004251 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1112204004252 generic binding surface II; other site 1112204004253 generic binding surface I; other site 1112204004254 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1112204004255 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1112204004256 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1112204004257 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1112204004258 active site 1112204004259 catalytic residues [active] 1112204004260 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1112204004261 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1112204004262 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1112204004263 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1112204004264 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1112204004265 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1112204004266 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1112204004267 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1112204004268 23S rRNA interface [nucleotide binding]; other site 1112204004269 L3 interface [polypeptide binding]; other site 1112204004270 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1112204004271 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1112204004272 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1112204004273 active site 1112204004274 substrate binding site [chemical binding]; other site 1112204004275 metal binding site [ion binding]; metal-binding site 1112204004276 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1112204004277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204004278 motif II; other site 1112204004279 chlorophyllase; Region: PLN00021 1112204004280 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1112204004281 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1112204004282 glutaminase active site [active] 1112204004283 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1112204004284 dimer interface [polypeptide binding]; other site 1112204004285 active site 1112204004286 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1112204004287 dimer interface [polypeptide binding]; other site 1112204004288 active site 1112204004289 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1112204004290 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1112204004291 putative substrate binding site [chemical binding]; other site 1112204004292 putative ATP binding site [chemical binding]; other site 1112204004293 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1112204004294 alanine racemase; Reviewed; Region: alr; PRK00053 1112204004295 active site 1112204004296 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1112204004297 dimer interface [polypeptide binding]; other site 1112204004298 substrate binding site [chemical binding]; other site 1112204004299 catalytic residues [active] 1112204004300 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204004301 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204004302 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1112204004303 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1112204004304 Glycoprotease family; Region: Peptidase_M22; pfam00814 1112204004305 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1112204004306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204004307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1112204004308 Coenzyme A binding pocket [chemical binding]; other site 1112204004309 UGMP family protein; Validated; Region: PRK09604 1112204004310 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1112204004311 MarR family; Region: MarR; pfam01047 1112204004312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204004313 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204004314 putative substrate translocation pore; other site 1112204004315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204004316 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1112204004317 oligomerisation interface [polypeptide binding]; other site 1112204004318 mobile loop; other site 1112204004319 roof hairpin; other site 1112204004320 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1112204004321 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1112204004322 ring oligomerisation interface [polypeptide binding]; other site 1112204004323 ATP/Mg binding site [chemical binding]; other site 1112204004324 stacking interactions; other site 1112204004325 hinge regions; other site 1112204004326 Transcription factor WhiB; Region: Whib; pfam02467 1112204004327 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1112204004328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204004329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204004330 DNA binding residues [nucleotide binding] 1112204004331 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1112204004332 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1112204004333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1112204004334 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1112204004335 active site 1112204004336 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1112204004337 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1112204004338 phosphate binding site [ion binding]; other site 1112204004339 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1112204004340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204004341 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1112204004342 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1112204004343 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1112204004344 Walker A/P-loop; other site 1112204004345 ATP binding site [chemical binding]; other site 1112204004346 Q-loop/lid; other site 1112204004347 ABC transporter signature motif; other site 1112204004348 Walker B; other site 1112204004349 D-loop; other site 1112204004350 H-loop/switch region; other site 1112204004351 BioY family; Region: BioY; pfam02632 1112204004352 GMP synthase; Reviewed; Region: guaA; PRK00074 1112204004353 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1112204004354 AMP/PPi binding site [chemical binding]; other site 1112204004355 candidate oxyanion hole; other site 1112204004356 catalytic triad [active] 1112204004357 potential glutamine specificity residues [chemical binding]; other site 1112204004358 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1112204004359 ATP Binding subdomain [chemical binding]; other site 1112204004360 Ligand Binding sites [chemical binding]; other site 1112204004361 Dimerization subdomain; other site 1112204004362 PspC domain; Region: PspC; cl00864 1112204004363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1112204004364 DsrE/DsrF-like family; Region: DrsE; pfam02635 1112204004365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204004366 ATP binding site [chemical binding]; other site 1112204004367 Mg2+ binding site [ion binding]; other site 1112204004368 G-X-G motif; other site 1112204004369 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204004370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204004371 active site 1112204004372 phosphorylation site [posttranslational modification] 1112204004373 intermolecular recognition site; other site 1112204004374 dimerization interface [polypeptide binding]; other site 1112204004375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204004376 dimerization interface [polypeptide binding]; other site 1112204004377 DNA binding residues [nucleotide binding] 1112204004378 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204004379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204004380 active site 1112204004381 ATP binding site [chemical binding]; other site 1112204004382 substrate binding site [chemical binding]; other site 1112204004383 activation loop (A-loop); other site 1112204004384 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1112204004385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204004386 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1112204004387 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1112204004388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204004389 FeS/SAM binding site; other site 1112204004390 DNA Polymerase Y-family; Region: PolY_like; cd03468 1112204004391 active site 1112204004392 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1112204004393 DNA binding site [nucleotide binding] 1112204004394 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1112204004395 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1112204004396 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1112204004397 catalytic residue [active] 1112204004398 short chain dehydrogenase; Provisional; Region: PRK07201 1112204004399 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1112204004400 putative NAD(P) binding site [chemical binding]; other site 1112204004401 active site 1112204004402 putative substrate binding site [chemical binding]; other site 1112204004403 classical (c) SDRs; Region: SDR_c; cd05233 1112204004404 NAD(P) binding site [chemical binding]; other site 1112204004405 active site 1112204004406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204004407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204004408 Carboxylesterase family; Region: COesterase; pfam00135 1112204004409 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1112204004410 substrate binding pocket [chemical binding]; other site 1112204004411 catalytic triad [active] 1112204004412 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1112204004413 dimer interface [polypeptide binding]; other site 1112204004414 ligand binding site [chemical binding]; other site 1112204004415 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1112204004416 active site 1112204004417 catalytic residues [active] 1112204004418 metal binding site [ion binding]; metal-binding site 1112204004419 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1112204004420 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1112204004421 active site 1112204004422 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1112204004423 generic binding surface II; other site 1112204004424 generic binding surface I; other site 1112204004425 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1112204004426 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1112204004427 Catalytic site [active] 1112204004428 Cutinase; Region: Cutinase; pfam01083 1112204004429 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1112204004430 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1112204004431 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1112204004432 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1112204004433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204004434 catalytic residue [active] 1112204004435 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1112204004436 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1112204004437 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1112204004438 homodimer interface [polypeptide binding]; other site 1112204004439 NADP binding site [chemical binding]; other site 1112204004440 substrate binding site [chemical binding]; other site 1112204004441 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1112204004442 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204004443 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1112204004444 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1112204004445 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1112204004446 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1112204004447 homodimer interface [polypeptide binding]; other site 1112204004448 substrate-cofactor binding pocket; other site 1112204004449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204004450 catalytic residue [active] 1112204004451 PE-PPE domain; Region: PE-PPE; pfam08237 1112204004452 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1112204004453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204004454 putative substrate translocation pore; other site 1112204004455 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1112204004456 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1112204004457 heme binding site [chemical binding]; other site 1112204004458 ferroxidase pore; other site 1112204004459 ferroxidase diiron center [ion binding]; other site 1112204004460 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1112204004461 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1112204004462 putative catalytic site [active] 1112204004463 putative metal binding site [ion binding]; other site 1112204004464 putative phosphate binding site [ion binding]; other site 1112204004465 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1112204004466 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1112204004467 active site 1112204004468 HIGH motif; other site 1112204004469 dimer interface [polypeptide binding]; other site 1112204004470 KMSKS motif; other site 1112204004471 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1112204004472 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1112204004473 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1112204004474 hypothetical protein; Provisional; Region: PRK06541 1112204004475 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204004476 inhibitor-cofactor binding pocket; inhibition site 1112204004477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204004478 catalytic residue [active] 1112204004479 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204004480 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1112204004481 putative DNA binding site [nucleotide binding]; other site 1112204004482 putative Zn2+ binding site [ion binding]; other site 1112204004483 AsnC family; Region: AsnC_trans_reg; pfam01037 1112204004484 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1112204004485 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1112204004486 NAD(P) binding site [chemical binding]; other site 1112204004487 catalytic residues [active] 1112204004488 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1112204004489 FAD dependent oxidoreductase; Region: DAO; pfam01266 1112204004490 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204004491 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1112204004492 CoenzymeA binding site [chemical binding]; other site 1112204004493 subunit interaction site [polypeptide binding]; other site 1112204004494 PHB binding site; other site 1112204004495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204004496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204004497 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1112204004498 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1112204004499 catalytic triad [active] 1112204004500 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204004501 Ligand Binding Site [chemical binding]; other site 1112204004502 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204004503 Ligand Binding Site [chemical binding]; other site 1112204004504 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204004505 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1112204004506 putative active site [active] 1112204004507 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1112204004508 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1112204004509 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1112204004510 L-aspartate oxidase; Provisional; Region: PRK06175 1112204004511 Archaeal flagella protein; Region: Arch_fla_DE; cl01322 1112204004512 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1112204004513 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1112204004514 putative Iron-sulfur protein interface [polypeptide binding]; other site 1112204004515 putative proximal heme binding site [chemical binding]; other site 1112204004516 putative SdhC-like subunit interface [polypeptide binding]; other site 1112204004517 putative distal heme binding site [chemical binding]; other site 1112204004518 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1112204004519 putative Iron-sulfur protein interface [polypeptide binding]; other site 1112204004520 putative proximal heme binding site [chemical binding]; other site 1112204004521 putative SdhD-like interface [polypeptide binding]; other site 1112204004522 putative distal heme binding site [chemical binding]; other site 1112204004523 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1112204004524 active site 1112204004525 catalytic motif [active] 1112204004526 Zn binding site [ion binding]; other site 1112204004527 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1112204004528 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1112204004529 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1112204004530 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1112204004531 adenosine deaminase; Provisional; Region: PRK09358 1112204004532 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1112204004533 active site 1112204004534 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1112204004535 NlpC/P60 family; Region: NLPC_P60; pfam00877 1112204004536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204004537 active site 1112204004538 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1112204004539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204004540 Walker A/P-loop; other site 1112204004541 ATP binding site [chemical binding]; other site 1112204004542 Q-loop/lid; other site 1112204004543 ABC transporter signature motif; other site 1112204004544 Walker B; other site 1112204004545 D-loop; other site 1112204004546 H-loop/switch region; other site 1112204004547 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1112204004548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204004549 substrate binding site [chemical binding]; other site 1112204004550 oxyanion hole (OAH) forming residues; other site 1112204004551 trimer interface [polypeptide binding]; other site 1112204004552 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1112204004553 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1112204004554 metal binding site [ion binding]; metal-binding site 1112204004555 putative dimer interface [polypeptide binding]; other site 1112204004556 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1112204004557 putative active site pocket [active] 1112204004558 dimerization interface [polypeptide binding]; other site 1112204004559 putative catalytic residue [active] 1112204004560 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1112204004561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204004562 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1112204004563 glycerol kinase; Region: glycerol_kin; TIGR01311 1112204004564 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1112204004565 N- and C-terminal domain interface [polypeptide binding]; other site 1112204004566 active site 1112204004567 MgATP binding site [chemical binding]; other site 1112204004568 catalytic site [active] 1112204004569 metal binding site [ion binding]; metal-binding site 1112204004570 putative homotetramer interface [polypeptide binding]; other site 1112204004571 glycerol binding site [chemical binding]; other site 1112204004572 homodimer interface [polypeptide binding]; other site 1112204004573 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1112204004574 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1112204004575 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204004576 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204004577 active site 1112204004578 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1112204004579 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1112204004580 putative DNA binding site [nucleotide binding]; other site 1112204004581 catalytic residue [active] 1112204004582 putative H2TH interface [polypeptide binding]; other site 1112204004583 putative catalytic residues [active] 1112204004584 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1112204004585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204004586 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1112204004587 ATP binding site [chemical binding]; other site 1112204004588 putative Mg++ binding site [ion binding]; other site 1112204004589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204004590 nucleotide binding region [chemical binding]; other site 1112204004591 ATP-binding site [chemical binding]; other site 1112204004592 DEAD/H associated; Region: DEAD_assoc; pfam08494 1112204004593 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1112204004594 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1112204004595 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1112204004596 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 1112204004597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204004598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204004599 active site 1112204004600 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1112204004601 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1112204004602 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1112204004603 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1112204004604 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1112204004605 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1112204004606 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1112204004607 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1112204004608 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1112204004609 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1112204004610 active site 1112204004611 putative substrate binding pocket [chemical binding]; other site 1112204004612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204004613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204004614 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204004615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204004616 non-specific DNA binding site [nucleotide binding]; other site 1112204004617 salt bridge; other site 1112204004618 sequence-specific DNA binding site [nucleotide binding]; other site 1112204004619 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1112204004620 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1112204004621 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1112204004622 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1112204004623 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1112204004624 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1112204004625 tetramer interface [polypeptide binding]; other site 1112204004626 active site 1112204004627 Mg2+/Mn2+ binding site [ion binding]; other site 1112204004628 citrate synthase; Provisional; Region: PRK14033 1112204004629 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1112204004630 dimer interface [polypeptide binding]; other site 1112204004631 active site 1112204004632 citrylCoA binding site [chemical binding]; other site 1112204004633 oxalacetate/citrate binding site [chemical binding]; other site 1112204004634 coenzyme A binding site [chemical binding]; other site 1112204004635 catalytic triad [active] 1112204004636 pyruvate carboxylase; Reviewed; Region: PRK12999 1112204004637 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204004638 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204004639 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1112204004640 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1112204004641 active site 1112204004642 catalytic residues [active] 1112204004643 metal binding site [ion binding]; metal-binding site 1112204004644 homodimer binding site [polypeptide binding]; other site 1112204004645 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1112204004646 carboxyltransferase (CT) interaction site; other site 1112204004647 biotinylation site [posttranslational modification]; other site 1112204004648 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1112204004649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204004650 non-specific DNA binding site [nucleotide binding]; other site 1112204004651 salt bridge; other site 1112204004652 sequence-specific DNA binding site [nucleotide binding]; other site 1112204004653 Cupin domain; Region: Cupin_2; pfam07883 1112204004654 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1112204004655 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1112204004656 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1112204004657 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204004658 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1112204004659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204004660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204004661 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1112204004662 putative active site [active] 1112204004663 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1112204004664 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1112204004665 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1112204004666 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1112204004667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204004668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204004669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204004670 dimerization interface [polypeptide binding]; other site 1112204004671 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1112204004672 methionine synthase; Provisional; Region: PRK01207 1112204004673 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1112204004674 substrate binding site [chemical binding]; other site 1112204004675 THF binding site; other site 1112204004676 zinc-binding site [ion binding]; other site 1112204004677 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1112204004678 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1112204004679 THF binding site; other site 1112204004680 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1112204004681 substrate binding site [chemical binding]; other site 1112204004682 THF binding site; other site 1112204004683 zinc-binding site [ion binding]; other site 1112204004684 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1112204004685 active site 1112204004686 homotetramer interface [polypeptide binding]; other site 1112204004687 putative OHCU decarboxylase; Provisional; Region: PRK13798 1112204004688 xanthine permease; Region: pbuX; TIGR03173 1112204004689 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1112204004690 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1112204004691 Ligand binding site; other site 1112204004692 metal-binding site 1112204004693 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1112204004694 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204004695 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1112204004696 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1112204004697 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1112204004698 carboxyltransferase (CT) interaction site; other site 1112204004699 biotinylation site [posttranslational modification]; other site 1112204004700 Condensation domain; Region: Condensation; pfam00668 1112204004701 Fe-S metabolism associated domain; Region: SufE; cl00951 1112204004702 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1112204004703 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1112204004704 active site residue [active] 1112204004705 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1112204004706 active site residue [active] 1112204004707 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1112204004708 Maf-like protein; Region: Maf; pfam02545 1112204004709 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1112204004710 active site 1112204004711 dimer interface [polypeptide binding]; other site 1112204004712 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1112204004713 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1112204004714 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1112204004715 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1112204004716 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1112204004717 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1112204004718 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1112204004719 Bacterial PH domain; Region: DUF304; pfam03703 1112204004720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204004721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204004722 active site 1112204004723 phosphorylation site [posttranslational modification] 1112204004724 intermolecular recognition site; other site 1112204004725 dimerization interface [polypeptide binding]; other site 1112204004726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204004727 DNA binding site [nucleotide binding] 1112204004728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1112204004729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204004730 ATP binding site [chemical binding]; other site 1112204004731 Mg2+ binding site [ion binding]; other site 1112204004732 G-X-G motif; other site 1112204004733 Predicted membrane protein [Function unknown]; Region: COG2246 1112204004734 GtrA-like protein; Region: GtrA; pfam04138 1112204004735 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1112204004736 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204004737 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1112204004738 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1112204004739 Domain of unknown function (DUF385); Region: DUF385; cl04387 1112204004740 TIGR03089 family protein; Region: TIGR03089 1112204004741 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1112204004742 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1112204004743 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1112204004744 NADP binding site [chemical binding]; other site 1112204004745 active site 1112204004746 putative substrate binding site [chemical binding]; other site 1112204004747 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1112204004748 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1112204004749 Probable Catalytic site; other site 1112204004750 metal-binding site 1112204004751 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1112204004752 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1112204004753 active site 1112204004754 Substrate binding site; other site 1112204004755 Mg++ binding site; other site 1112204004756 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1112204004757 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1112204004758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204004759 S-adenosylmethionine binding site [chemical binding]; other site 1112204004760 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1112204004761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204004762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204004763 DNA binding residues [nucleotide binding] 1112204004764 serine endoprotease; Provisional; Region: PRK10898 1112204004765 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1112204004766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1112204004767 protein binding site [polypeptide binding]; other site 1112204004768 sec-independent translocase; Provisional; Region: tatB; PRK00182 1112204004769 sec-independent translocase; Provisional; Region: PRK03100 1112204004770 Domain of unknown function DUF59; Region: DUF59; cl00941 1112204004771 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1112204004772 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1112204004773 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1112204004774 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1112204004775 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1112204004776 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1112204004777 MgtE intracellular N domain; Region: MgtE_N; smart00924 1112204004778 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1112204004779 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1112204004780 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1112204004781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204004782 dimer interface [polypeptide binding]; other site 1112204004783 conserved gate region; other site 1112204004784 putative PBP binding loops; other site 1112204004785 ABC-ATPase subunit interface; other site 1112204004786 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1112204004787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204004788 dimer interface [polypeptide binding]; other site 1112204004789 conserved gate region; other site 1112204004790 putative PBP binding loops; other site 1112204004791 ABC-ATPase subunit interface; other site 1112204004792 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1112204004793 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1112204004794 Walker A/P-loop; other site 1112204004795 ATP binding site [chemical binding]; other site 1112204004796 Q-loop/lid; other site 1112204004797 ABC transporter signature motif; other site 1112204004798 Walker B; other site 1112204004799 D-loop; other site 1112204004800 H-loop/switch region; other site 1112204004801 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1112204004802 active site 1112204004803 metal binding site [ion binding]; metal-binding site 1112204004804 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1112204004805 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 1112204004806 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1112204004807 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1112204004808 putative ligand binding site [chemical binding]; other site 1112204004809 MarR family; Region: MarR_2; pfam12802 1112204004810 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1112204004811 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1112204004812 Helix-turn-helix domain; Region: HTH_18; pfam12833 1112204004813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204004814 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1112204004815 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1112204004816 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1112204004817 oligomer interface [polypeptide binding]; other site 1112204004818 metal binding site [ion binding]; metal-binding site 1112204004819 metal binding site [ion binding]; metal-binding site 1112204004820 putative Cl binding site [ion binding]; other site 1112204004821 basic sphincter; other site 1112204004822 hydrophobic gate; other site 1112204004823 periplasmic entrance; other site 1112204004824 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1112204004825 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1112204004826 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1112204004827 short chain dehydrogenase; Provisional; Region: PRK07832 1112204004828 classical (c) SDRs; Region: SDR_c; cd05233 1112204004829 NAD(P) binding site [chemical binding]; other site 1112204004830 active site 1112204004831 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204004832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204004833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204004834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204004835 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1112204004836 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1112204004837 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1112204004838 TPP-binding site [chemical binding]; other site 1112204004839 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1112204004840 dimer interface [polypeptide binding]; other site 1112204004841 PYR/PP interface [polypeptide binding]; other site 1112204004842 TPP binding site [chemical binding]; other site 1112204004843 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204004844 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204004845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204004846 Walker A/P-loop; other site 1112204004847 ATP binding site [chemical binding]; other site 1112204004848 Q-loop/lid; other site 1112204004849 ABC transporter signature motif; other site 1112204004850 Walker B; other site 1112204004851 D-loop; other site 1112204004852 H-loop/switch region; other site 1112204004853 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204004854 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204004855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204004856 Walker A/P-loop; other site 1112204004857 ATP binding site [chemical binding]; other site 1112204004858 Q-loop/lid; other site 1112204004859 ABC transporter signature motif; other site 1112204004860 Walker B; other site 1112204004861 D-loop; other site 1112204004862 H-loop/switch region; other site 1112204004863 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1112204004864 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1112204004865 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1112204004866 putative dimer interface [polypeptide binding]; other site 1112204004867 N-terminal domain interface [polypeptide binding]; other site 1112204004868 putative substrate binding pocket (H-site) [chemical binding]; other site 1112204004869 Predicted transcriptional regulators [Transcription]; Region: COG1695 1112204004870 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1112204004871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204004872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204004873 putative substrate translocation pore; other site 1112204004874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204004875 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1112204004876 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1112204004877 active site 1112204004878 metal binding site [ion binding]; metal-binding site 1112204004879 DNA binding site [nucleotide binding] 1112204004880 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1112204004881 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1112204004882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204004883 Walker A/P-loop; other site 1112204004884 ATP binding site [chemical binding]; other site 1112204004885 Q-loop/lid; other site 1112204004886 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1112204004887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204004888 ABC transporter signature motif; other site 1112204004889 Walker B; other site 1112204004890 D-loop; other site 1112204004891 H-loop/switch region; other site 1112204004892 enoyl-CoA hydratase; Provisional; Region: PRK07509 1112204004893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204004894 substrate binding site [chemical binding]; other site 1112204004895 oxyanion hole (OAH) forming residues; other site 1112204004896 trimer interface [polypeptide binding]; other site 1112204004897 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1112204004898 putative dimer interface [polypeptide binding]; other site 1112204004899 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204004900 Cupin domain; Region: Cupin_2; cl17218 1112204004901 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1112204004902 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1112204004903 putative active site [active] 1112204004904 putative dimer interface [polypeptide binding]; other site 1112204004905 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1112204004906 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1112204004907 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1112204004908 active site 1112204004909 HIGH motif; other site 1112204004910 KMSK motif region; other site 1112204004911 DALR anticodon binding domain; Region: DALR_1; smart00836 1112204004912 anticodon binding site; other site 1112204004913 tRNA binding surface [nucleotide binding]; other site 1112204004914 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1112204004915 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1112204004916 active site 1112204004917 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1112204004918 substrate binding site [chemical binding]; other site 1112204004919 catalytic residues [active] 1112204004920 dimer interface [polypeptide binding]; other site 1112204004921 homoserine dehydrogenase; Provisional; Region: PRK06349 1112204004922 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1112204004923 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1112204004924 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1112204004925 threonine synthase; Reviewed; Region: PRK06721 1112204004926 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1112204004927 homodimer interface [polypeptide binding]; other site 1112204004928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204004929 catalytic residue [active] 1112204004930 homoserine kinase; Provisional; Region: PRK01212 1112204004931 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1112204004932 transcription termination factor Rho; Provisional; Region: PRK12608 1112204004933 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1112204004934 RNA binding site [nucleotide binding]; other site 1112204004935 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1112204004936 multimer interface [polypeptide binding]; other site 1112204004937 Walker A motif; other site 1112204004938 ATP binding site [chemical binding]; other site 1112204004939 Walker B motif; other site 1112204004940 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1112204004941 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1112204004942 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1112204004943 Flavodoxin; Region: Flavodoxin_1; pfam00258 1112204004944 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1112204004945 FAD binding pocket [chemical binding]; other site 1112204004946 FAD binding motif [chemical binding]; other site 1112204004947 catalytic residues [active] 1112204004948 NAD binding pocket [chemical binding]; other site 1112204004949 phosphate binding motif [ion binding]; other site 1112204004950 beta-alpha-beta structure motif; other site 1112204004951 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1112204004952 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1112204004953 active site 1112204004954 dimer interface [polypeptide binding]; other site 1112204004955 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1112204004956 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1112204004957 active site 1112204004958 FMN binding site [chemical binding]; other site 1112204004959 substrate binding site [chemical binding]; other site 1112204004960 3Fe-4S cluster binding site [ion binding]; other site 1112204004961 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1112204004962 domain_subunit interface; other site 1112204004963 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1112204004964 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1112204004965 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1112204004966 RF-1 domain; Region: RF-1; pfam00472 1112204004967 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1112204004968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204004969 S-adenosylmethionine binding site [chemical binding]; other site 1112204004970 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1112204004971 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204004972 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1112204004973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204004974 catalytic residue [active] 1112204004975 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1112204004976 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1112204004977 Mg++ binding site [ion binding]; other site 1112204004978 putative catalytic motif [active] 1112204004979 substrate binding site [chemical binding]; other site 1112204004980 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1112204004981 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1112204004982 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1112204004983 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1112204004984 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1112204004985 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1112204004986 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1112204004987 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1112204004988 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1112204004989 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1112204004990 beta subunit interaction interface [polypeptide binding]; other site 1112204004991 Walker A motif; other site 1112204004992 ATP binding site [chemical binding]; other site 1112204004993 Walker B motif; other site 1112204004994 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1112204004995 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1112204004996 core domain interface [polypeptide binding]; other site 1112204004997 delta subunit interface [polypeptide binding]; other site 1112204004998 epsilon subunit interface [polypeptide binding]; other site 1112204004999 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1112204005000 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1112204005001 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1112204005002 alpha subunit interaction interface [polypeptide binding]; other site 1112204005003 Walker A motif; other site 1112204005004 ATP binding site [chemical binding]; other site 1112204005005 Walker B motif; other site 1112204005006 inhibitor binding site; inhibition site 1112204005007 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1112204005008 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1112204005009 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1112204005010 gamma subunit interface [polypeptide binding]; other site 1112204005011 epsilon subunit interface [polypeptide binding]; other site 1112204005012 LBP interface [polypeptide binding]; other site 1112204005013 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1112204005014 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1112204005015 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1112204005016 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1112204005017 hinge; other site 1112204005018 active site 1112204005019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204005020 dimerization interface [polypeptide binding]; other site 1112204005021 putative DNA binding site [nucleotide binding]; other site 1112204005022 putative Zn2+ binding site [ion binding]; other site 1112204005023 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1112204005024 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1112204005025 DNA binding residues [nucleotide binding] 1112204005026 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1112204005027 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204005028 DNA binding residues [nucleotide binding] 1112204005029 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 1112204005030 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1112204005031 PDGLE domain; Region: PDGLE; pfam13190 1112204005032 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1112204005033 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1112204005034 Walker A/P-loop; other site 1112204005035 ATP binding site [chemical binding]; other site 1112204005036 ABC transporter; Region: ABC_tran; pfam00005 1112204005037 Q-loop/lid; other site 1112204005038 ABC transporter signature motif; other site 1112204005039 Walker B; other site 1112204005040 D-loop; other site 1112204005041 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 1112204005042 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1112204005043 active site 1112204005044 NAD binding site [chemical binding]; other site 1112204005045 metal binding site [ion binding]; metal-binding site 1112204005046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204005047 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1112204005048 Walker A motif; other site 1112204005049 ATP binding site [chemical binding]; other site 1112204005050 Walker B motif; other site 1112204005051 arginine finger; other site 1112204005052 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1112204005053 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1112204005054 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1112204005055 active site 1112204005056 NAD binding site [chemical binding]; other site 1112204005057 metal binding site [ion binding]; metal-binding site 1112204005058 Histidine kinase; Region: HisKA_3; pfam07730 1112204005059 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1112204005060 ATP binding site [chemical binding]; other site 1112204005061 Mg2+ binding site [ion binding]; other site 1112204005062 G-X-G motif; other site 1112204005063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204005064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204005065 active site 1112204005066 phosphorylation site [posttranslational modification] 1112204005067 intermolecular recognition site; other site 1112204005068 dimerization interface [polypeptide binding]; other site 1112204005069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204005070 dimerization interface [polypeptide binding]; other site 1112204005071 DNA binding residues [nucleotide binding] 1112204005072 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1112204005073 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204005074 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204005075 Ligand Binding Site [chemical binding]; other site 1112204005076 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204005077 Ligand Binding Site [chemical binding]; other site 1112204005078 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204005079 Ligand Binding Site [chemical binding]; other site 1112204005080 SnoaL-like domain; Region: SnoaL_2; pfam12680 1112204005081 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204005082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204005083 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1112204005084 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1112204005085 glutaminase; Provisional; Region: PRK00971 1112204005086 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1112204005087 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1112204005088 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1112204005089 hypothetical protein; Provisional; Region: PRK03298 1112204005090 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1112204005091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204005092 dimer interface [polypeptide binding]; other site 1112204005093 substrate binding site [chemical binding]; other site 1112204005094 metal binding site [ion binding]; metal-binding site 1112204005095 putative acyltransferase; Provisional; Region: PRK05790 1112204005096 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204005097 dimer interface [polypeptide binding]; other site 1112204005098 active site 1112204005099 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1112204005100 Domain of unknown function DUF77; Region: DUF77; pfam01910 1112204005101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204005102 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1112204005103 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1112204005104 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1112204005105 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204005106 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1112204005107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204005108 Walker A/P-loop; other site 1112204005109 ATP binding site [chemical binding]; other site 1112204005110 Q-loop/lid; other site 1112204005111 ABC transporter signature motif; other site 1112204005112 Walker B; other site 1112204005113 D-loop; other site 1112204005114 H-loop/switch region; other site 1112204005115 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 1112204005116 Predicted transcriptional regulators [Transcription]; Region: COG1695 1112204005117 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1112204005118 glycogen branching enzyme; Provisional; Region: PRK05402 1112204005119 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1112204005120 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1112204005121 active site 1112204005122 catalytic site [active] 1112204005123 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1112204005124 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1112204005125 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1112204005126 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1112204005127 active site 1112204005128 homodimer interface [polypeptide binding]; other site 1112204005129 catalytic site [active] 1112204005130 acceptor binding site [chemical binding]; other site 1112204005131 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1112204005132 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1112204005133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204005134 putative Mg++ binding site [ion binding]; other site 1112204005135 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1112204005136 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1112204005137 Isochorismatase family; Region: Isochorismatase; pfam00857 1112204005138 catalytic triad [active] 1112204005139 metal binding site [ion binding]; metal-binding site 1112204005140 conserved cis-peptide bond; other site 1112204005141 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1112204005142 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1112204005143 active site 1112204005144 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1112204005145 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1112204005146 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1112204005147 putative active site pocket [active] 1112204005148 cleavage site 1112204005149 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1112204005150 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1112204005151 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1112204005152 MPN+ (JAMM) motif; other site 1112204005153 Zinc-binding site [ion binding]; other site 1112204005154 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1112204005155 MoaE interaction surface [polypeptide binding]; other site 1112204005156 MoeB interaction surface [polypeptide binding]; other site 1112204005157 thiocarboxylated glycine; other site 1112204005158 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1112204005159 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1112204005160 dimer interface [polypeptide binding]; other site 1112204005161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204005162 catalytic residue [active] 1112204005163 Rhomboid family; Region: Rhomboid; pfam01694 1112204005164 glutamate racemase; Provisional; Region: PRK00865 1112204005165 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1112204005166 ribonuclease PH; Reviewed; Region: rph; PRK00173 1112204005167 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1112204005168 hexamer interface [polypeptide binding]; other site 1112204005169 active site 1112204005170 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1112204005171 active site 1112204005172 dimerization interface [polypeptide binding]; other site 1112204005173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204005174 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1112204005175 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1112204005176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204005177 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1112204005178 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1112204005179 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1112204005180 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1112204005181 NAD(P) binding site [chemical binding]; other site 1112204005182 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1112204005183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204005184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204005185 WHG domain; Region: WHG; pfam13305 1112204005186 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1112204005187 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1112204005188 potential catalytic triad [active] 1112204005189 conserved cys residue [active] 1112204005190 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1112204005191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204005192 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1112204005193 dimerization interface [polypeptide binding]; other site 1112204005194 substrate binding pocket [chemical binding]; other site 1112204005195 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204005196 classical (c) SDRs; Region: SDR_c; cd05233 1112204005197 NAD(P) binding site [chemical binding]; other site 1112204005198 active site 1112204005199 Short C-terminal domain; Region: SHOCT; pfam09851 1112204005200 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1112204005201 dimer interface [polypeptide binding]; other site 1112204005202 ADP-ribose binding site [chemical binding]; other site 1112204005203 active site 1112204005204 nudix motif; other site 1112204005205 metal binding site [ion binding]; metal-binding site 1112204005206 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1112204005207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204005208 S-adenosylmethionine binding site [chemical binding]; other site 1112204005209 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1112204005210 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1112204005211 active site 1112204005212 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1112204005213 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204005214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204005215 catalytic residue [active] 1112204005216 OpgC protein; Region: OpgC_C; cl17858 1112204005217 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1112204005218 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1112204005219 acyl-activating enzyme (AAE) consensus motif; other site 1112204005220 putative AMP binding site [chemical binding]; other site 1112204005221 putative active site [active] 1112204005222 putative CoA binding site [chemical binding]; other site 1112204005223 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1112204005224 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1112204005225 ATP binding site [chemical binding]; other site 1112204005226 Mg++ binding site [ion binding]; other site 1112204005227 motif III; other site 1112204005228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204005229 nucleotide binding region [chemical binding]; other site 1112204005230 ATP-binding site [chemical binding]; other site 1112204005231 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1112204005232 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1112204005233 Part of AAA domain; Region: AAA_19; pfam13245 1112204005234 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1112204005235 AAA domain; Region: AAA_12; pfam13087 1112204005236 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1112204005237 putative active site [active] 1112204005238 NAD-dependent deacetylase; Provisional; Region: PRK00481 1112204005239 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1112204005240 NAD+ binding site [chemical binding]; other site 1112204005241 substrate binding site [chemical binding]; other site 1112204005242 Zn binding site [ion binding]; other site 1112204005243 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1112204005244 HIT family signature motif; other site 1112204005245 catalytic residue [active] 1112204005246 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1112204005247 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1112204005248 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1112204005249 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1112204005250 putative active site [active] 1112204005251 putative catalytic site [active] 1112204005252 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1112204005253 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1112204005254 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1112204005255 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1112204005256 putative NAD(P) binding site [chemical binding]; other site 1112204005257 active site 1112204005258 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1112204005259 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1112204005260 active site 1112204005261 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1112204005262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204005263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204005264 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1112204005265 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1112204005266 catalytic triad [active] 1112204005267 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1112204005268 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1112204005269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1112204005270 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1112204005271 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1112204005272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1112204005273 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1112204005274 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1112204005275 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204005276 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204005277 active site 1112204005278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204005279 dimerization interface [polypeptide binding]; other site 1112204005280 putative DNA binding site [nucleotide binding]; other site 1112204005281 putative Zn2+ binding site [ion binding]; other site 1112204005282 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1112204005283 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1112204005284 ABC1 family; Region: ABC1; cl17513 1112204005285 serine/threonine protein kinase; Provisional; Region: PRK14879 1112204005286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204005287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204005288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204005289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204005290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204005291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204005292 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1112204005293 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1112204005294 catalytic site [active] 1112204005295 putative active site [active] 1112204005296 putative substrate binding site [chemical binding]; other site 1112204005297 dimer interface [polypeptide binding]; other site 1112204005298 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1112204005299 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1112204005300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204005301 NAD(P) binding site [chemical binding]; other site 1112204005302 active site 1112204005303 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1112204005304 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1112204005305 active site 1112204005306 FMN binding site [chemical binding]; other site 1112204005307 2,4-decadienoyl-CoA binding site; other site 1112204005308 catalytic residue [active] 1112204005309 4Fe-4S cluster binding site [ion binding]; other site 1112204005310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204005311 Predicted transcriptional regulators [Transcription]; Region: COG1695 1112204005312 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1112204005313 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1112204005314 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204005315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204005316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204005317 Walker A/P-loop; other site 1112204005318 ATP binding site [chemical binding]; other site 1112204005319 Q-loop/lid; other site 1112204005320 ABC transporter signature motif; other site 1112204005321 Walker B; other site 1112204005322 D-loop; other site 1112204005323 H-loop/switch region; other site 1112204005324 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1112204005325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204005326 active site 1112204005327 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1112204005328 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1112204005329 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1112204005330 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204005331 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204005332 ABC transporter; Region: ABC_tran_2; pfam12848 1112204005333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204005334 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1112204005335 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1112204005336 active site 1112204005337 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1112204005338 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1112204005339 active site 1112204005340 catalytic site [active] 1112204005341 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1112204005342 apolar tunnel; other site 1112204005343 heme binding site [chemical binding]; other site 1112204005344 dimerization interface [polypeptide binding]; other site 1112204005345 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1112204005346 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204005347 active site 1112204005348 Repair protein; Region: Repair_PSII; cl01535 1112204005349 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1112204005350 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1112204005351 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1112204005352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204005353 ATP binding site [chemical binding]; other site 1112204005354 Mg2+ binding site [ion binding]; other site 1112204005355 G-X-G motif; other site 1112204005356 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1112204005357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204005358 active site 1112204005359 dimerization interface [polypeptide binding]; other site 1112204005360 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1112204005361 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1112204005362 Zn binding site [ion binding]; other site 1112204005363 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1112204005364 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1112204005365 catalytic residues [active] 1112204005366 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1112204005367 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1112204005368 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1112204005369 putative DNA binding site [nucleotide binding]; other site 1112204005370 catalytic residue [active] 1112204005371 putative H2TH interface [polypeptide binding]; other site 1112204005372 putative catalytic residues [active] 1112204005373 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1112204005374 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1112204005375 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1112204005376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204005377 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1112204005378 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1112204005379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1112204005380 Secretory lipase; Region: LIP; pfam03583 1112204005381 Cytochrome P450; Region: p450; cl12078 1112204005382 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204005383 Histidine kinase; Region: HisKA_3; pfam07730 1112204005384 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1112204005385 Mg2+ binding site [ion binding]; other site 1112204005386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204005387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204005388 active site 1112204005389 phosphorylation site [posttranslational modification] 1112204005390 intermolecular recognition site; other site 1112204005391 dimerization interface [polypeptide binding]; other site 1112204005392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204005393 DNA binding residues [nucleotide binding] 1112204005394 dimerization interface [polypeptide binding]; other site 1112204005395 trigger factor; Provisional; Region: tig; PRK01490 1112204005396 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1112204005397 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1112204005398 Clp protease; Region: CLP_protease; pfam00574 1112204005399 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1112204005400 oligomer interface [polypeptide binding]; other site 1112204005401 active site residues [active] 1112204005402 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1112204005403 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1112204005404 oligomer interface [polypeptide binding]; other site 1112204005405 active site residues [active] 1112204005406 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1112204005407 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1112204005408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204005409 Walker A motif; other site 1112204005410 ATP binding site [chemical binding]; other site 1112204005411 Walker B motif; other site 1112204005412 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1112204005413 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1112204005414 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1112204005415 GTP binding site; other site 1112204005416 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1112204005417 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1112204005418 active site 1112204005419 HIGH motif; other site 1112204005420 nucleotide binding site [chemical binding]; other site 1112204005421 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1112204005422 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1112204005423 active site 1112204005424 KMSKS motif; other site 1112204005425 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1112204005426 tRNA binding surface [nucleotide binding]; other site 1112204005427 anticodon binding site; other site 1112204005428 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1112204005429 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1112204005430 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1112204005431 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1112204005432 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1112204005433 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1112204005434 active site 1112204005435 multimer interface [polypeptide binding]; other site 1112204005436 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1112204005437 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1112204005438 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1112204005439 homodimer interface [polypeptide binding]; other site 1112204005440 oligonucleotide binding site [chemical binding]; other site 1112204005441 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1112204005442 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1112204005443 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1112204005444 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1112204005445 GTP1/OBG; Region: GTP1_OBG; pfam01018 1112204005446 Obg GTPase; Region: Obg; cd01898 1112204005447 G1 box; other site 1112204005448 GTP/Mg2+ binding site [chemical binding]; other site 1112204005449 Switch I region; other site 1112204005450 G2 box; other site 1112204005451 G3 box; other site 1112204005452 Switch II region; other site 1112204005453 G4 box; other site 1112204005454 G5 box; other site 1112204005455 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1112204005456 gamma-glutamyl kinase; Provisional; Region: PRK05429 1112204005457 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1112204005458 nucleotide binding site [chemical binding]; other site 1112204005459 homotetrameric interface [polypeptide binding]; other site 1112204005460 putative phosphate binding site [ion binding]; other site 1112204005461 putative allosteric binding site; other site 1112204005462 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1112204005463 NAD-dependent deacetylase; Provisional; Region: PRK05333 1112204005464 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1112204005465 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1112204005466 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1112204005467 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204005468 inhibitor-cofactor binding pocket; inhibition site 1112204005469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204005470 catalytic residue [active] 1112204005471 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1112204005472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204005473 Coenzyme A binding pocket [chemical binding]; other site 1112204005474 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1112204005475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204005476 S-adenosylmethionine binding site [chemical binding]; other site 1112204005477 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1112204005478 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1112204005479 active site 1112204005480 (T/H)XGH motif; other site 1112204005481 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1112204005482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204005483 dimer interface [polypeptide binding]; other site 1112204005484 conserved gate region; other site 1112204005485 putative PBP binding loops; other site 1112204005486 ABC-ATPase subunit interface; other site 1112204005487 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1112204005488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204005489 Walker A/P-loop; other site 1112204005490 ATP binding site [chemical binding]; other site 1112204005491 Q-loop/lid; other site 1112204005492 ABC transporter signature motif; other site 1112204005493 Walker B; other site 1112204005494 D-loop; other site 1112204005495 H-loop/switch region; other site 1112204005496 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1112204005497 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1112204005498 substrate binding pocket [chemical binding]; other site 1112204005499 membrane-bound complex binding site; other site 1112204005500 hinge residues; other site 1112204005501 putative acetyltransferase; Provisional; Region: PRK03624 1112204005502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204005503 Coenzyme A binding pocket [chemical binding]; other site 1112204005504 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1112204005505 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1112204005506 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1112204005507 ribonuclease III; Reviewed; Region: rnc; PRK00102 1112204005508 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1112204005509 dimerization interface [polypeptide binding]; other site 1112204005510 active site 1112204005511 metal binding site [ion binding]; metal-binding site 1112204005512 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1112204005513 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1112204005514 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1112204005515 DNA binding site [nucleotide binding] 1112204005516 catalytic residue [active] 1112204005517 H2TH interface [polypeptide binding]; other site 1112204005518 putative catalytic residues [active] 1112204005519 turnover-facilitating residue; other site 1112204005520 intercalation triad [nucleotide binding]; other site 1112204005521 8OG recognition residue [nucleotide binding]; other site 1112204005522 putative reading head residues; other site 1112204005523 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1112204005524 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1112204005525 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1112204005526 acylphosphatase; Provisional; Region: PRK14422 1112204005527 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1112204005528 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1112204005529 Walker A/P-loop; other site 1112204005530 ATP binding site [chemical binding]; other site 1112204005531 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1112204005532 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1112204005533 ABC transporter signature motif; other site 1112204005534 Walker B; other site 1112204005535 D-loop; other site 1112204005536 H-loop/switch region; other site 1112204005537 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1112204005538 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1112204005539 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204005540 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1112204005541 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1112204005542 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1112204005543 PII uridylyl-transferase; Provisional; Region: PRK03381 1112204005544 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1112204005545 metal binding triad; other site 1112204005546 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1112204005547 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1112204005548 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1112204005549 signal recognition particle protein; Provisional; Region: PRK10867 1112204005550 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1112204005551 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1112204005552 P loop; other site 1112204005553 GTP binding site [chemical binding]; other site 1112204005554 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1112204005555 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1112204005556 active site 1112204005557 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1112204005558 hypothetical protein; Provisional; Region: PRK02821 1112204005559 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1112204005560 G-X-X-G motif; other site 1112204005561 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1112204005562 RimM N-terminal domain; Region: RimM; pfam01782 1112204005563 PRC-barrel domain; Region: PRC; pfam05239 1112204005564 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1112204005565 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1112204005566 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1112204005567 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1112204005568 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1112204005569 Catalytic site [active] 1112204005570 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1112204005571 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1112204005572 RNA/DNA hybrid binding site [nucleotide binding]; other site 1112204005573 active site 1112204005574 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1112204005575 hypothetical protein; Reviewed; Region: PRK12497 1112204005576 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1112204005577 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1112204005578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204005579 Walker A motif; other site 1112204005580 ATP binding site [chemical binding]; other site 1112204005581 Walker B motif; other site 1112204005582 arginine finger; other site 1112204005583 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1112204005584 DNA protecting protein DprA; Region: dprA; TIGR00732 1112204005585 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1112204005586 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1112204005587 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1112204005588 FAD binding pocket [chemical binding]; other site 1112204005589 FAD binding motif [chemical binding]; other site 1112204005590 phosphate binding motif [ion binding]; other site 1112204005591 NAD binding pocket [chemical binding]; other site 1112204005592 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1112204005593 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1112204005594 active site 1112204005595 DNA binding site [nucleotide binding] 1112204005596 Int/Topo IB signature motif; other site 1112204005597 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1112204005598 Peptidase family M23; Region: Peptidase_M23; pfam01551 1112204005599 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1112204005600 rRNA interaction site [nucleotide binding]; other site 1112204005601 S8 interaction site; other site 1112204005602 putative laminin-1 binding site; other site 1112204005603 elongation factor Ts; Provisional; Region: tsf; PRK09377 1112204005604 UBA/TS-N domain; Region: UBA; pfam00627 1112204005605 Elongation factor TS; Region: EF_TS; pfam00889 1112204005606 Elongation factor TS; Region: EF_TS; pfam00889 1112204005607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204005608 putative substrate translocation pore; other site 1112204005609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204005610 Condensation domain; Region: Condensation; pfam00668 1112204005611 Predicted esterase [General function prediction only]; Region: COG0627 1112204005612 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1112204005613 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1112204005614 putative nucleotide binding site [chemical binding]; other site 1112204005615 uridine monophosphate binding site [chemical binding]; other site 1112204005616 homohexameric interface [polypeptide binding]; other site 1112204005617 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1112204005618 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1112204005619 hinge region; other site 1112204005620 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1112204005621 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1112204005622 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1112204005623 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1112204005624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204005625 FeS/SAM binding site; other site 1112204005626 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1112204005627 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1112204005628 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1112204005629 active site 1112204005630 catalytic site [active] 1112204005631 tetramer interface [polypeptide binding]; other site 1112204005632 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1112204005633 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1112204005634 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1112204005635 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1112204005636 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1112204005637 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1112204005638 active site 1112204005639 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1112204005640 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1112204005641 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1112204005642 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1112204005643 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1112204005644 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1112204005645 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1112204005646 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1112204005647 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1112204005648 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1112204005649 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1112204005650 Walker A/P-loop; other site 1112204005651 ATP binding site [chemical binding]; other site 1112204005652 Q-loop/lid; other site 1112204005653 ABC transporter signature motif; other site 1112204005654 Walker B; other site 1112204005655 D-loop; other site 1112204005656 H-loop/switch region; other site 1112204005657 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1112204005658 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1112204005659 dimer interface [polypeptide binding]; other site 1112204005660 putative PBP binding regions; other site 1112204005661 ABC-ATPase subunit interface; other site 1112204005662 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1112204005663 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1112204005664 intersubunit interface [polypeptide binding]; other site 1112204005665 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1112204005666 active site 1112204005667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204005668 NAD(P) binding site [chemical binding]; other site 1112204005669 active site 1112204005670 Predicted transcriptional regulators [Transcription]; Region: COG1733 1112204005671 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1112204005672 cobyric acid synthase; Provisional; Region: PRK00784 1112204005673 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1112204005674 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1112204005675 catalytic triad [active] 1112204005676 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204005677 mycothione reductase; Reviewed; Region: PRK07846 1112204005678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204005679 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1112204005680 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1112204005681 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204005682 malate:quinone oxidoreductase; Validated; Region: PRK05257 1112204005683 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1112204005684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1112204005685 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1112204005686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204005687 Walker A motif; other site 1112204005688 ATP binding site [chemical binding]; other site 1112204005689 Walker B motif; other site 1112204005690 arginine finger; other site 1112204005691 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1112204005692 metal ion-dependent adhesion site (MIDAS); other site 1112204005693 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1112204005694 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1112204005695 homodimer interface [polypeptide binding]; other site 1112204005696 Walker A motif; other site 1112204005697 ATP binding site [chemical binding]; other site 1112204005698 hydroxycobalamin binding site [chemical binding]; other site 1112204005699 Walker B motif; other site 1112204005700 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1112204005701 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204005702 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1112204005703 catalytic triad [active] 1112204005704 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1112204005705 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1112204005706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1112204005707 Histidine kinase; Region: HisKA_3; pfam07730 1112204005708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204005709 Mg2+ binding site [ion binding]; other site 1112204005710 G-X-G motif; other site 1112204005711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204005712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204005713 active site 1112204005714 phosphorylation site [posttranslational modification] 1112204005715 intermolecular recognition site; other site 1112204005716 dimerization interface [polypeptide binding]; other site 1112204005717 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204005718 DNA binding residues [nucleotide binding] 1112204005719 dimerization interface [polypeptide binding]; other site 1112204005720 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1112204005721 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1112204005722 homodimer interface [polypeptide binding]; other site 1112204005723 putative substrate binding pocket [chemical binding]; other site 1112204005724 diiron center [ion binding]; other site 1112204005725 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1112204005726 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1112204005727 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1112204005728 homodimer interface [polypeptide binding]; other site 1112204005729 active site 1112204005730 SAM binding site [chemical binding]; other site 1112204005731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204005732 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204005733 putative substrate translocation pore; other site 1112204005734 hypothetical protein; Validated; Region: PRK02101 1112204005735 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1112204005736 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1112204005737 dimer interface [polypeptide binding]; other site 1112204005738 motif 1; other site 1112204005739 active site 1112204005740 motif 2; other site 1112204005741 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1112204005742 putative deacylase active site [active] 1112204005743 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1112204005744 active site 1112204005745 motif 3; other site 1112204005746 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1112204005747 anticodon binding site; other site 1112204005748 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1112204005749 dinuclear metal binding motif [ion binding]; other site 1112204005750 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1112204005751 Sm and related proteins; Region: Sm_like; cl00259 1112204005752 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1112204005753 putative oligomer interface [polypeptide binding]; other site 1112204005754 putative RNA binding site [nucleotide binding]; other site 1112204005755 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1112204005756 NusA N-terminal domain; Region: NusA_N; pfam08529 1112204005757 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1112204005758 RNA binding site [nucleotide binding]; other site 1112204005759 homodimer interface [polypeptide binding]; other site 1112204005760 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1112204005761 G-X-X-G motif; other site 1112204005762 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1112204005763 G-X-X-G motif; other site 1112204005764 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1112204005765 putative RNA binding cleft [nucleotide binding]; other site 1112204005766 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1112204005767 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1112204005768 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1112204005769 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1112204005770 G1 box; other site 1112204005771 putative GEF interaction site [polypeptide binding]; other site 1112204005772 GTP/Mg2+ binding site [chemical binding]; other site 1112204005773 Switch I region; other site 1112204005774 G2 box; other site 1112204005775 G3 box; other site 1112204005776 Switch II region; other site 1112204005777 G4 box; other site 1112204005778 G5 box; other site 1112204005779 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1112204005780 Translation-initiation factor 2; Region: IF-2; pfam11987 1112204005781 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1112204005782 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1112204005783 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1112204005784 DHH family; Region: DHH; pfam01368 1112204005785 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1112204005786 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1112204005787 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1112204005788 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1112204005789 active site 1112204005790 metal binding site [ion binding]; metal-binding site 1112204005791 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1112204005792 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1112204005793 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1112204005794 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1112204005795 RNA binding site [nucleotide binding]; other site 1112204005796 active site 1112204005797 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1112204005798 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1112204005799 non-specific DNA interactions [nucleotide binding]; other site 1112204005800 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1112204005801 DNA binding site [nucleotide binding] 1112204005802 sequence specific DNA binding site [nucleotide binding]; other site 1112204005803 putative cAMP binding site [chemical binding]; other site 1112204005804 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1112204005805 FeoA domain; Region: FeoA; pfam04023 1112204005806 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1112204005807 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1112204005808 active site 1112204005809 Riboflavin kinase; Region: Flavokinase; smart00904 1112204005810 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1112204005811 16S/18S rRNA binding site [nucleotide binding]; other site 1112204005812 S13e-L30e interaction site [polypeptide binding]; other site 1112204005813 25S rRNA binding site [nucleotide binding]; other site 1112204005814 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1112204005815 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1112204005816 oligomer interface [polypeptide binding]; other site 1112204005817 RNA binding site [nucleotide binding]; other site 1112204005818 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1112204005819 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1112204005820 RNase E interface [polypeptide binding]; other site 1112204005821 trimer interface [polypeptide binding]; other site 1112204005822 active site 1112204005823 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1112204005824 putative nucleic acid binding region [nucleotide binding]; other site 1112204005825 G-X-X-G motif; other site 1112204005826 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1112204005827 RNA binding site [nucleotide binding]; other site 1112204005828 domain interface; other site 1112204005829 NRDE protein; Region: NRDE; cl01315 1112204005830 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1112204005831 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1112204005832 hexamer interface [polypeptide binding]; other site 1112204005833 ligand binding site [chemical binding]; other site 1112204005834 putative active site [active] 1112204005835 NAD(P) binding site [chemical binding]; other site 1112204005836 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204005837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204005838 putative DNA binding site [nucleotide binding]; other site 1112204005839 putative Zn2+ binding site [ion binding]; other site 1112204005840 AsnC family; Region: AsnC_trans_reg; pfam01037 1112204005841 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1112204005842 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1112204005843 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1112204005844 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1112204005845 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1112204005846 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1112204005847 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1112204005848 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1112204005849 dimerization interface [polypeptide binding]; other site 1112204005850 active site 1112204005851 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1112204005852 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1112204005853 folate binding site [chemical binding]; other site 1112204005854 NADP+ binding site [chemical binding]; other site 1112204005855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1112204005856 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1112204005857 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1112204005858 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1112204005859 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1112204005860 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1112204005861 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204005862 acyl-activating enzyme (AAE) consensus motif; other site 1112204005863 AMP binding site [chemical binding]; other site 1112204005864 active site 1112204005865 CoA binding site [chemical binding]; other site 1112204005866 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 1112204005867 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1112204005868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204005869 NAD(P) binding site [chemical binding]; other site 1112204005870 active site 1112204005871 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 1112204005872 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1112204005873 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1112204005874 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1112204005875 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204005876 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204005877 Cytochrome P450; Region: p450; cl12078 1112204005878 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1112204005879 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1112204005880 homodimer interface [polypeptide binding]; other site 1112204005881 active site 1112204005882 TDP-binding site; other site 1112204005883 acceptor substrate-binding pocket; other site 1112204005884 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1112204005885 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1112204005886 PhoD-like phosphatase; Region: PhoD; pfam09423 1112204005887 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1112204005888 putative active site [active] 1112204005889 putative metal binding site [ion binding]; other site 1112204005890 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1112204005891 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1112204005892 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1112204005893 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1112204005894 dimer interface [polypeptide binding]; other site 1112204005895 active site 1112204005896 catalytic residue [active] 1112204005897 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1112204005898 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1112204005899 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1112204005900 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1112204005901 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1112204005902 TIGR03085 family protein; Region: TIGR03085 1112204005903 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1112204005904 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1112204005905 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1112204005906 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1112204005907 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1112204005908 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1112204005909 YCII-related domain; Region: YCII; cl00999 1112204005910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204005911 Coenzyme A binding pocket [chemical binding]; other site 1112204005912 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1112204005913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204005914 non-specific DNA binding site [nucleotide binding]; other site 1112204005915 salt bridge; other site 1112204005916 sequence-specific DNA binding site [nucleotide binding]; other site 1112204005917 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1112204005918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1112204005919 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1112204005920 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1112204005921 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 1112204005922 hexamer interface [polypeptide binding]; other site 1112204005923 Walker A motif; other site 1112204005924 ATP binding site [chemical binding]; other site 1112204005925 Walker B motif; other site 1112204005926 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1112204005927 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1112204005928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204005929 dimer interface [polypeptide binding]; other site 1112204005930 conserved gate region; other site 1112204005931 putative PBP binding loops; other site 1112204005932 ABC-ATPase subunit interface; other site 1112204005933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204005934 dimer interface [polypeptide binding]; other site 1112204005935 conserved gate region; other site 1112204005936 putative PBP binding loops; other site 1112204005937 ABC-ATPase subunit interface; other site 1112204005938 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1112204005939 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1112204005940 substrate binding pocket [chemical binding]; other site 1112204005941 membrane-bound complex binding site; other site 1112204005942 hinge residues; other site 1112204005943 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1112204005944 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1112204005945 Walker A/P-loop; other site 1112204005946 ATP binding site [chemical binding]; other site 1112204005947 Q-loop/lid; other site 1112204005948 ABC transporter signature motif; other site 1112204005949 Walker B; other site 1112204005950 D-loop; other site 1112204005951 H-loop/switch region; other site 1112204005952 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1112204005953 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1112204005954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204005955 FeS/SAM binding site; other site 1112204005956 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1112204005957 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1112204005958 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1112204005959 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1112204005960 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1112204005961 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1112204005962 IPP transferase; Region: IPPT; pfam01715 1112204005963 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1112204005964 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1112204005965 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1112204005966 GTPases [General function prediction only]; Region: HflX; COG2262 1112204005967 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1112204005968 HflX GTPase family; Region: HflX; cd01878 1112204005969 G1 box; other site 1112204005970 GTP/Mg2+ binding site [chemical binding]; other site 1112204005971 Switch I region; other site 1112204005972 G2 box; other site 1112204005973 G3 box; other site 1112204005974 Switch II region; other site 1112204005975 G4 box; other site 1112204005976 G5 box; other site 1112204005977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204005978 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1112204005979 Cupin domain; Region: Cupin_2; cl17218 1112204005980 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1112204005981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204005982 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1112204005983 dimerization domain swap beta strand [polypeptide binding]; other site 1112204005984 regulatory protein interface [polypeptide binding]; other site 1112204005985 active site 1112204005986 regulatory phosphorylation site [posttranslational modification]; other site 1112204005987 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1112204005988 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1112204005989 active site 1112204005990 phosphorylation site [posttranslational modification] 1112204005991 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1112204005992 active site 1112204005993 P-loop; other site 1112204005994 phosphorylation site [posttranslational modification] 1112204005995 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1112204005996 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1112204005997 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1112204005998 putative substrate binding site [chemical binding]; other site 1112204005999 putative ATP binding site [chemical binding]; other site 1112204006000 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1112204006001 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1112204006002 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1112204006003 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1112204006004 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1112204006005 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1112204006006 LexA repressor; Validated; Region: PRK00215 1112204006007 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1112204006008 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1112204006009 Catalytic site [active] 1112204006010 LysM domain; Region: LysM; pfam01476 1112204006011 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1112204006012 ATP cone domain; Region: ATP-cone; pfam03477 1112204006013 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1112204006014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204006015 ATP binding site [chemical binding]; other site 1112204006016 putative Mg++ binding site [ion binding]; other site 1112204006017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204006018 nucleotide binding region [chemical binding]; other site 1112204006019 ATP-binding site [chemical binding]; other site 1112204006020 Helicase associated domain (HA2); Region: HA2; pfam04408 1112204006021 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1112204006022 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1112204006023 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1112204006024 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204006025 inhibitor-cofactor binding pocket; inhibition site 1112204006026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204006027 catalytic residue [active] 1112204006028 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1112204006029 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1112204006030 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1112204006031 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1112204006032 dimer interface [polypeptide binding]; other site 1112204006033 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1112204006034 catalytic triad [active] 1112204006035 peroxidatic and resolving cysteines [active] 1112204006036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204006037 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1112204006038 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1112204006039 dimerization interface [polypeptide binding]; other site 1112204006040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204006041 ATP binding site [chemical binding]; other site 1112204006042 putative Mg++ binding site [ion binding]; other site 1112204006043 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204006044 nucleotide binding region [chemical binding]; other site 1112204006045 ATP-binding site [chemical binding]; other site 1112204006046 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1112204006047 PAC2 family; Region: PAC2; pfam09754 1112204006048 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1112204006049 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1112204006050 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1112204006051 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1112204006052 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1112204006053 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1112204006054 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1112204006055 active site 1112204006056 Zn binding site [ion binding]; other site 1112204006057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1112204006058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204006059 Coenzyme A binding pocket [chemical binding]; other site 1112204006060 CoA binding domain; Region: CoA_binding_2; pfam13380 1112204006061 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1112204006062 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1112204006063 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1112204006064 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1112204006065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204006066 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1112204006067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204006068 DNA binding residues [nucleotide binding] 1112204006069 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1112204006070 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1112204006071 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1112204006072 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1112204006073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204006074 ATP binding site [chemical binding]; other site 1112204006075 putative Mg++ binding site [ion binding]; other site 1112204006076 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1112204006077 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1112204006078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204006079 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1112204006080 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204006081 DNA binding residues [nucleotide binding] 1112204006082 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204006083 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1112204006084 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1112204006085 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1112204006086 active site 1112204006087 dimerization interface [polypeptide binding]; other site 1112204006088 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1112204006089 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1112204006090 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1112204006091 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1112204006092 trimer interface [polypeptide binding]; other site 1112204006093 active site 1112204006094 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1112204006095 pyrimidine utilization protein D; Region: RutD; TIGR03611 1112204006096 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1112204006097 ssDNA binding site; other site 1112204006098 generic binding surface II; other site 1112204006099 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1112204006100 TrkA-N domain; Region: TrkA_N; pfam02254 1112204006101 TrkA-C domain; Region: TrkA_C; pfam02080 1112204006102 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1112204006103 TrkA-N domain; Region: TrkA_N; pfam02254 1112204006104 TrkA-C domain; Region: TrkA_C; pfam02080 1112204006105 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204006106 TRAM domain; Region: TRAM; pfam01938 1112204006107 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1112204006108 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1112204006109 TPP-binding site; other site 1112204006110 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1112204006111 PYR/PP interface [polypeptide binding]; other site 1112204006112 dimer interface [polypeptide binding]; other site 1112204006113 TPP binding site [chemical binding]; other site 1112204006114 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1112204006115 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1112204006116 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1112204006117 catalytic site [active] 1112204006118 putative active site [active] 1112204006119 putative substrate binding site [chemical binding]; other site 1112204006120 HRDC domain; Region: HRDC; cl02578 1112204006121 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1112204006122 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1112204006123 substrate binding site [chemical binding]; other site 1112204006124 active site 1112204006125 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1112204006126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204006127 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1112204006128 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1112204006129 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1112204006130 SelR domain; Region: SelR; pfam01641 1112204006131 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1112204006132 TAP-like protein; Region: Abhydrolase_4; pfam08386 1112204006133 hypothetical protein; Provisional; Region: PRK14059 1112204006134 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1112204006135 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1112204006136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1112204006137 Walker A motif; other site 1112204006138 ATP binding site [chemical binding]; other site 1112204006139 Walker B motif; other site 1112204006140 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204006141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204006142 active site 1112204006143 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204006144 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1112204006145 putative active site [active] 1112204006146 putative substrate binding site [chemical binding]; other site 1112204006147 ATP binding site [chemical binding]; other site 1112204006148 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1112204006149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204006150 Coenzyme A binding pocket [chemical binding]; other site 1112204006151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204006152 S-adenosylmethionine binding site [chemical binding]; other site 1112204006153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204006154 NAD(P) binding site [chemical binding]; other site 1112204006155 active site 1112204006156 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1112204006157 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1112204006158 catalytic residues [active] 1112204006159 catalytic nucleophile [active] 1112204006160 Presynaptic Site I dimer interface [polypeptide binding]; other site 1112204006161 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1112204006162 Synaptic Flat tetramer interface [polypeptide binding]; other site 1112204006163 Synaptic Site I dimer interface [polypeptide binding]; other site 1112204006164 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1112204006165 DNA-binding interface [nucleotide binding]; DNA binding site 1112204006166 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1112204006167 active site 1112204006168 phosphate binding residues; other site 1112204006169 catalytic residues [active] 1112204006170 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1112204006171 Carboxylesterase family; Region: COesterase; pfam00135 1112204006172 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1112204006173 substrate binding pocket [chemical binding]; other site 1112204006174 catalytic triad [active] 1112204006175 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1112204006176 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1112204006177 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1112204006178 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1112204006179 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1112204006180 active site 1112204006181 dimer interface [polypeptide binding]; other site 1112204006182 motif 1; other site 1112204006183 motif 2; other site 1112204006184 motif 3; other site 1112204006185 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1112204006186 anticodon binding site; other site 1112204006187 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1112204006188 nucleotide binding site/active site [active] 1112204006189 HIT family signature motif; other site 1112204006190 catalytic residue [active] 1112204006191 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1112204006192 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1112204006193 putative acyl-acceptor binding pocket; other site 1112204006194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204006195 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1112204006196 LemA family; Region: LemA; cl00742 1112204006197 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1112204006198 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1112204006199 active site 1112204006200 multimer interface [polypeptide binding]; other site 1112204006201 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1112204006202 active site 1112204006203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204006204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204006205 DNA binding residues [nucleotide binding] 1112204006206 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1112204006207 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1112204006208 active site 1112204006209 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1112204006210 catalytic triad [active] 1112204006211 dimer interface [polypeptide binding]; other site 1112204006212 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1112204006213 predicted active site [active] 1112204006214 catalytic triad [active] 1112204006215 hypothetical protein; Validated; Region: PRK00110 1112204006216 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1112204006217 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1112204006218 active site 1112204006219 putative DNA-binding cleft [nucleotide binding]; other site 1112204006220 dimer interface [polypeptide binding]; other site 1112204006221 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1112204006222 RuvA N terminal domain; Region: RuvA_N; pfam01330 1112204006223 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1112204006224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204006225 Walker A motif; other site 1112204006226 ATP binding site [chemical binding]; other site 1112204006227 Walker B motif; other site 1112204006228 arginine finger; other site 1112204006229 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1112204006230 Preprotein translocase subunit; Region: YajC; pfam02699 1112204006231 protein-export membrane protein SecD; Region: secD; TIGR01129 1112204006232 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1112204006233 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1112204006234 Protein export membrane protein; Region: SecD_SecF; pfam02355 1112204006235 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1112204006236 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1112204006237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204006238 active site 1112204006239 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1112204006240 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1112204006241 Zn2+ binding site [ion binding]; other site 1112204006242 Mg2+ binding site [ion binding]; other site 1112204006243 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1112204006244 synthetase active site [active] 1112204006245 NTP binding site [chemical binding]; other site 1112204006246 metal binding site [ion binding]; metal-binding site 1112204006247 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1112204006248 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1112204006249 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1112204006250 active site 1112204006251 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1112204006252 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1112204006253 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1112204006254 dimer interface [polypeptide binding]; other site 1112204006255 motif 1; other site 1112204006256 active site 1112204006257 motif 2; other site 1112204006258 motif 3; other site 1112204006259 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1112204006260 anticodon binding site; other site 1112204006261 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1112204006262 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1112204006263 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1112204006264 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1112204006265 dimer interface [polypeptide binding]; other site 1112204006266 anticodon binding site; other site 1112204006267 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1112204006268 homodimer interface [polypeptide binding]; other site 1112204006269 motif 1; other site 1112204006270 active site 1112204006271 motif 2; other site 1112204006272 GAD domain; Region: GAD; pfam02938 1112204006273 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1112204006274 active site 1112204006275 motif 3; other site 1112204006276 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1112204006277 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1112204006278 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1112204006279 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1112204006280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1112204006281 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1112204006282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1112204006283 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1112204006284 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1112204006285 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1112204006286 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1112204006287 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1112204006288 recombination factor protein RarA; Reviewed; Region: PRK13342 1112204006289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204006290 Walker A motif; other site 1112204006291 ATP binding site [chemical binding]; other site 1112204006292 Walker B motif; other site 1112204006293 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1112204006294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204006295 D-galactonate transporter; Region: 2A0114; TIGR00893 1112204006296 putative substrate translocation pore; other site 1112204006297 OsmC-like protein; Region: OsmC; cl00767 1112204006298 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1112204006299 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1112204006300 motif 1; other site 1112204006301 active site 1112204006302 motif 2; other site 1112204006303 motif 3; other site 1112204006304 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1112204006305 DHHA1 domain; Region: DHHA1; pfam02272 1112204006306 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1112204006307 YceG-like family; Region: YceG; pfam02618 1112204006308 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1112204006309 dimerization interface [polypeptide binding]; other site 1112204006310 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1112204006311 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1112204006312 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1112204006313 shikimate binding site; other site 1112204006314 NAD(P) binding site [chemical binding]; other site 1112204006315 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1112204006316 chorismate synthase; Validated; Region: PRK05382 1112204006317 Tetramer interface [polypeptide binding]; other site 1112204006318 active site 1112204006319 FMN-binding site [chemical binding]; other site 1112204006320 shikimate kinase; Reviewed; Region: aroK; PRK00131 1112204006321 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1112204006322 ADP binding site [chemical binding]; other site 1112204006323 magnesium binding site [ion binding]; other site 1112204006324 putative shikimate binding site; other site 1112204006325 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1112204006326 dimer interface [polypeptide binding]; other site 1112204006327 active site 1112204006328 metal binding site [ion binding]; metal-binding site 1112204006329 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1112204006330 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1112204006331 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1112204006332 active site 1112204006333 elongation factor P; Validated; Region: PRK00529 1112204006334 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1112204006335 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1112204006336 RNA binding site [nucleotide binding]; other site 1112204006337 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1112204006338 RNA binding site [nucleotide binding]; other site 1112204006339 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1112204006340 putative RNA binding site [nucleotide binding]; other site 1112204006341 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1112204006342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204006343 active site 1112204006344 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1112204006345 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1112204006346 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1112204006347 dihydroorotase; Validated; Region: pyrC; PRK09357 1112204006348 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1112204006349 active site 1112204006350 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1112204006351 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1112204006352 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1112204006353 catalytic site [active] 1112204006354 subunit interface [polypeptide binding]; other site 1112204006355 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1112204006356 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204006357 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204006358 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1112204006359 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204006360 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204006361 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1112204006362 IMP binding site; other site 1112204006363 dimer interface [polypeptide binding]; other site 1112204006364 interdomain contacts; other site 1112204006365 partial ornithine binding site; other site 1112204006366 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1112204006367 active site 1112204006368 dimer interface [polypeptide binding]; other site 1112204006369 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204006370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204006371 active site 1112204006372 phosphorylation site [posttranslational modification] 1112204006373 intermolecular recognition site; other site 1112204006374 dimerization interface [polypeptide binding]; other site 1112204006375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204006376 DNA binding residues [nucleotide binding] 1112204006377 dimerization interface [polypeptide binding]; other site 1112204006378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1112204006379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204006380 ATP binding site [chemical binding]; other site 1112204006381 Mg2+ binding site [ion binding]; other site 1112204006382 G-X-G motif; other site 1112204006383 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1112204006384 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1112204006385 catalytic site [active] 1112204006386 G-X2-G-X-G-K; other site 1112204006387 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1112204006388 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1112204006389 Flavoprotein; Region: Flavoprotein; pfam02441 1112204006390 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1112204006391 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1112204006392 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1112204006393 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1112204006394 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1112204006395 primosome assembly protein PriA; Provisional; Region: PRK14873 1112204006396 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1112204006397 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1112204006398 putative active site [active] 1112204006399 substrate binding site [chemical binding]; other site 1112204006400 putative cosubstrate binding site; other site 1112204006401 catalytic site [active] 1112204006402 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1112204006403 substrate binding site [chemical binding]; other site 1112204006404 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1112204006405 putative RNA binding site [nucleotide binding]; other site 1112204006406 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1112204006407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204006408 S-adenosylmethionine binding site [chemical binding]; other site 1112204006409 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204006410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204006411 sequence-specific DNA binding site [nucleotide binding]; other site 1112204006412 salt bridge; other site 1112204006413 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1112204006414 active site 1112204006415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1112204006416 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1112204006417 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1112204006418 substrate binding site [chemical binding]; other site 1112204006419 hexamer interface [polypeptide binding]; other site 1112204006420 metal binding site [ion binding]; metal-binding site 1112204006421 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1112204006422 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1112204006423 catalytic motif [active] 1112204006424 Zn binding site [ion binding]; other site 1112204006425 RibD C-terminal domain; Region: RibD_C; pfam01872 1112204006426 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1112204006427 Lumazine binding domain; Region: Lum_binding; pfam00677 1112204006428 Lumazine binding domain; Region: Lum_binding; pfam00677 1112204006429 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1112204006430 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1112204006431 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1112204006432 dimerization interface [polypeptide binding]; other site 1112204006433 active site 1112204006434 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1112204006435 homopentamer interface [polypeptide binding]; other site 1112204006436 active site 1112204006437 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1112204006438 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1112204006439 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1112204006440 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1112204006441 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1112204006442 GIY-YIG motif/motif A; other site 1112204006443 active site 1112204006444 catalytic site [active] 1112204006445 putative DNA binding site [nucleotide binding]; other site 1112204006446 metal binding site [ion binding]; metal-binding site 1112204006447 UvrB/uvrC motif; Region: UVR; pfam02151 1112204006448 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1112204006449 Helix-hairpin-helix motif; Region: HHH; pfam00633 1112204006450 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1112204006451 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1112204006452 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1112204006453 phosphate binding site [ion binding]; other site 1112204006454 putative substrate binding pocket [chemical binding]; other site 1112204006455 dimer interface [polypeptide binding]; other site 1112204006456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1112204006457 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1112204006458 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1112204006459 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1112204006460 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1112204006461 Phosphoglycerate kinase; Region: PGK; pfam00162 1112204006462 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1112204006463 substrate binding site [chemical binding]; other site 1112204006464 hinge regions; other site 1112204006465 ADP binding site [chemical binding]; other site 1112204006466 catalytic site [active] 1112204006467 triosephosphate isomerase; Provisional; Region: PRK14567 1112204006468 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1112204006469 substrate binding site [chemical binding]; other site 1112204006470 dimer interface [polypeptide binding]; other site 1112204006471 catalytic triad [active] 1112204006472 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1112204006473 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1112204006474 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1112204006475 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1112204006476 putative active site [active] 1112204006477 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1112204006478 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1112204006479 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1112204006480 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1112204006481 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1112204006482 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1112204006483 putative active site [active] 1112204006484 transaldolase; Provisional; Region: PRK03903 1112204006485 catalytic residue [active] 1112204006486 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1112204006487 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1112204006488 TPP-binding site [chemical binding]; other site 1112204006489 dimer interface [polypeptide binding]; other site 1112204006490 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1112204006491 PYR/PP interface [polypeptide binding]; other site 1112204006492 dimer interface [polypeptide binding]; other site 1112204006493 TPP binding site [chemical binding]; other site 1112204006494 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1112204006495 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1112204006496 UbiA prenyltransferase family; Region: UbiA; pfam01040 1112204006497 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1112204006498 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1112204006499 NADP binding site [chemical binding]; other site 1112204006500 dimer interface [polypeptide binding]; other site 1112204006501 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1112204006502 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204006503 active site 1112204006504 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204006505 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1112204006506 short chain dehydrogenase; Provisional; Region: PRK06180 1112204006507 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1112204006508 NADP binding site [chemical binding]; other site 1112204006509 active site 1112204006510 steroid binding site; other site 1112204006511 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204006512 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1112204006513 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204006514 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1112204006515 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1112204006516 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1112204006517 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1112204006518 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1112204006519 Walker A/P-loop; other site 1112204006520 ATP binding site [chemical binding]; other site 1112204006521 Q-loop/lid; other site 1112204006522 ABC transporter signature motif; other site 1112204006523 Walker B; other site 1112204006524 D-loop; other site 1112204006525 H-loop/switch region; other site 1112204006526 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1112204006527 Predicted transcriptional regulator [Transcription]; Region: COG2345 1112204006528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204006529 putative DNA binding site [nucleotide binding]; other site 1112204006530 putative Zn2+ binding site [ion binding]; other site 1112204006531 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1112204006532 FeS assembly protein SufB; Region: sufB; TIGR01980 1112204006533 FeS assembly protein SufD; Region: sufD; TIGR01981 1112204006534 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1112204006535 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1112204006536 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1112204006537 Walker A/P-loop; other site 1112204006538 ATP binding site [chemical binding]; other site 1112204006539 Q-loop/lid; other site 1112204006540 ABC transporter signature motif; other site 1112204006541 Walker B; other site 1112204006542 D-loop; other site 1112204006543 H-loop/switch region; other site 1112204006544 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1112204006545 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1112204006546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204006547 catalytic residue [active] 1112204006548 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1112204006549 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1112204006550 trimerization site [polypeptide binding]; other site 1112204006551 active site 1112204006552 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1112204006553 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1112204006554 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1112204006555 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1112204006556 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1112204006557 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1112204006558 active site 1112204006559 metal binding site [ion binding]; metal-binding site 1112204006560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204006561 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 1112204006562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204006563 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1112204006564 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1112204006565 classical (c) SDRs; Region: SDR_c; cd05233 1112204006566 NAD(P) binding site [chemical binding]; other site 1112204006567 active site 1112204006568 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1112204006569 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1112204006570 active site 1112204006571 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1112204006572 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1112204006573 active site 1112204006574 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204006575 AMP-binding enzyme; Region: AMP-binding; pfam00501 1112204006576 acyl-activating enzyme (AAE) consensus motif; other site 1112204006577 AMP binding site [chemical binding]; other site 1112204006578 active site 1112204006579 CoA binding site [chemical binding]; other site 1112204006580 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204006581 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1112204006582 3-dehydroquinate synthase; Provisional; Region: PRK02290 1112204006583 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1112204006584 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1112204006585 putative active site; other site 1112204006586 catalytic residue [active] 1112204006587 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1112204006588 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1112204006589 Ligand binding site; other site 1112204006590 Putative Catalytic site; other site 1112204006591 DXD motif; other site 1112204006592 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1112204006593 active site 1112204006594 catalytic residues [active] 1112204006595 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1112204006596 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1112204006597 active site 1112204006598 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1112204006599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1112204006600 active site 1112204006601 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1112204006602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204006603 Walker A/P-loop; other site 1112204006604 ATP binding site [chemical binding]; other site 1112204006605 Q-loop/lid; other site 1112204006606 ABC transporter signature motif; other site 1112204006607 Walker B; other site 1112204006608 D-loop; other site 1112204006609 H-loop/switch region; other site 1112204006610 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204006611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204006612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1112204006613 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204006614 acyl-activating enzyme (AAE) consensus motif; other site 1112204006615 putative AMP binding site [chemical binding]; other site 1112204006616 putative active site [active] 1112204006617 putative CoA binding site [chemical binding]; other site 1112204006618 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1112204006619 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1112204006620 DNA binding site [nucleotide binding] 1112204006621 AAA ATPase domain; Region: AAA_16; pfam13191 1112204006622 Predicted ATPase [General function prediction only]; Region: COG3903 1112204006623 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1112204006624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204006625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204006626 homodimer interface [polypeptide binding]; other site 1112204006627 catalytic residue [active] 1112204006628 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1112204006629 active site 1112204006630 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1112204006631 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1112204006632 PYR/PP interface [polypeptide binding]; other site 1112204006633 dimer interface [polypeptide binding]; other site 1112204006634 TPP binding site [chemical binding]; other site 1112204006635 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1112204006636 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1112204006637 TPP-binding site [chemical binding]; other site 1112204006638 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1112204006639 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204006640 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1112204006641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204006642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204006643 aconitate hydratase; Validated; Region: PRK09277 1112204006644 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1112204006645 substrate binding site [chemical binding]; other site 1112204006646 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1112204006647 ligand binding site [chemical binding]; other site 1112204006648 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1112204006649 substrate binding site [chemical binding]; other site 1112204006650 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1112204006651 NlpC/P60 family; Region: NLPC_P60; pfam00877 1112204006652 MoxR-like ATPases [General function prediction only]; Region: COG0714 1112204006653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204006654 Walker A motif; other site 1112204006655 ATP binding site [chemical binding]; other site 1112204006656 Walker B motif; other site 1112204006657 arginine finger; other site 1112204006658 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1112204006659 Protein of unknown function DUF58; Region: DUF58; pfam01882 1112204006660 hypothetical protein; Provisional; Region: PRK13685 1112204006661 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1112204006662 metal ion-dependent adhesion site (MIDAS); other site 1112204006663 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1112204006664 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1112204006665 NAD(P) binding site [chemical binding]; other site 1112204006666 homotetramer interface [polypeptide binding]; other site 1112204006667 homodimer interface [polypeptide binding]; other site 1112204006668 active site 1112204006669 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1112204006670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204006671 NAD(P) binding site [chemical binding]; other site 1112204006672 active site 1112204006673 ferrochelatase; Reviewed; Region: hemH; PRK00035 1112204006674 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1112204006675 C-terminal domain interface [polypeptide binding]; other site 1112204006676 active site 1112204006677 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1112204006678 active site 1112204006679 N-terminal domain interface [polypeptide binding]; other site 1112204006680 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1112204006681 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1112204006682 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1112204006683 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1112204006684 Predicted esterase [General function prediction only]; Region: COG0627 1112204006685 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 1112204006686 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1112204006687 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1112204006688 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1112204006689 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1112204006690 heterodimer interface [polypeptide binding]; other site 1112204006691 substrate interaction site [chemical binding]; other site 1112204006692 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1112204006693 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1112204006694 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1112204006695 active site 1112204006696 substrate binding site [chemical binding]; other site 1112204006697 coenzyme B12 binding site [chemical binding]; other site 1112204006698 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1112204006699 B12 binding site [chemical binding]; other site 1112204006700 cobalt ligand [ion binding]; other site 1112204006701 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1112204006702 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1112204006703 Walker A; other site 1112204006704 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1112204006705 G4 box; other site 1112204006706 G5 box; other site 1112204006707 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1112204006708 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1112204006709 intersubunit interface [polypeptide binding]; other site 1112204006710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204006711 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1112204006712 NAD(P) binding site [chemical binding]; other site 1112204006713 active site 1112204006714 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1112204006715 Isochorismatase family; Region: Isochorismatase; pfam00857 1112204006716 catalytic triad [active] 1112204006717 conserved cis-peptide bond; other site 1112204006718 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1112204006719 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1112204006720 acyl-activating enzyme (AAE) consensus motif; other site 1112204006721 active site 1112204006722 AMP binding site [chemical binding]; other site 1112204006723 substrate binding site [chemical binding]; other site 1112204006724 enterobactin exporter EntS; Provisional; Region: PRK10489 1112204006725 Condensation domain; Region: Condensation; pfam00668 1112204006726 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204006727 Condensation domain; Region: Condensation; pfam00668 1112204006728 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204006729 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204006730 acyl-activating enzyme (AAE) consensus motif; other site 1112204006731 AMP binding site [chemical binding]; other site 1112204006732 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204006733 Condensation domain; Region: Condensation; pfam00668 1112204006734 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204006735 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204006736 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204006737 acyl-activating enzyme (AAE) consensus motif; other site 1112204006738 AMP binding site [chemical binding]; other site 1112204006739 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204006740 Condensation domain; Region: Condensation; pfam00668 1112204006741 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204006742 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204006743 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204006744 acyl-activating enzyme (AAE) consensus motif; other site 1112204006745 AMP binding site [chemical binding]; other site 1112204006746 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204006747 Condensation domain; Region: Condensation; pfam00668 1112204006748 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1112204006749 Condensation domain; Region: Condensation; pfam00668 1112204006750 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204006751 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204006752 acyl-activating enzyme (AAE) consensus motif; other site 1112204006753 AMP binding site [chemical binding]; other site 1112204006754 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204006755 Condensation domain; Region: Condensation; pfam00668 1112204006756 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204006757 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204006758 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204006759 acyl-activating enzyme (AAE) consensus motif; other site 1112204006760 AMP binding site [chemical binding]; other site 1112204006761 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204006762 Condensation domain; Region: Condensation; pfam00668 1112204006763 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1112204006764 Condensation domain; Region: Condensation; pfam00668 1112204006765 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204006766 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204006767 acyl-activating enzyme (AAE) consensus motif; other site 1112204006768 AMP binding site [chemical binding]; other site 1112204006769 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1112204006770 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1112204006771 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1112204006772 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1112204006773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204006774 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204006775 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1112204006776 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1112204006777 active site 1112204006778 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1112204006779 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1112204006780 hypothetical protein; Provisional; Region: PRK07906 1112204006781 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1112204006782 putative metal binding site [ion binding]; other site 1112204006783 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1112204006784 substrate binding site [chemical binding]; other site 1112204006785 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1112204006786 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1112204006787 quinone interaction residues [chemical binding]; other site 1112204006788 active site 1112204006789 catalytic residues [active] 1112204006790 FMN binding site [chemical binding]; other site 1112204006791 substrate binding site [chemical binding]; other site 1112204006792 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1112204006793 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204006794 catalytic core [active] 1112204006795 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1112204006796 conserved hypothetical protein; Region: TIGR03843 1112204006797 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1112204006798 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1112204006799 active site 1112204006800 HIGH motif; other site 1112204006801 nucleotide binding site [chemical binding]; other site 1112204006802 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1112204006803 active site 1112204006804 KMSKS motif; other site 1112204006805 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1112204006806 putative tRNA binding surface [nucleotide binding]; other site 1112204006807 PAC2 family; Region: PAC2; pfam09754 1112204006808 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1112204006809 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1112204006810 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1112204006811 substrate binding pocket [chemical binding]; other site 1112204006812 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1112204006813 B12 binding site [chemical binding]; other site 1112204006814 cobalt ligand [ion binding]; other site 1112204006815 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1112204006816 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1112204006817 DHH family; Region: DHH; pfam01368 1112204006818 DHHA2 domain; Region: DHHA2; pfam02833 1112204006819 Predicted integral membrane protein [Function unknown]; Region: COG5542 1112204006820 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1112204006821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204006822 motif II; other site 1112204006823 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1112204006824 homodimer interface [polypeptide binding]; other site 1112204006825 putative metal binding site [ion binding]; other site 1112204006826 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1112204006827 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1112204006828 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1112204006829 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1112204006830 PE-PPE domain; Region: PE-PPE; pfam08237 1112204006831 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1112204006832 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1112204006833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204006834 S-adenosylmethionine binding site [chemical binding]; other site 1112204006835 proteasome ATPase; Region: pup_AAA; TIGR03689 1112204006836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204006837 Walker A motif; other site 1112204006838 ATP binding site [chemical binding]; other site 1112204006839 Walker B motif; other site 1112204006840 arginine finger; other site 1112204006841 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1112204006842 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1112204006843 phosphopeptide binding site; other site 1112204006844 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1112204006845 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1112204006846 phosphopeptide binding site; other site 1112204006847 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1112204006848 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1112204006849 Walker A/P-loop; other site 1112204006850 ATP binding site [chemical binding]; other site 1112204006851 Q-loop/lid; other site 1112204006852 ABC transporter signature motif; other site 1112204006853 Walker B; other site 1112204006854 D-loop; other site 1112204006855 H-loop/switch region; other site 1112204006856 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1112204006857 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1112204006858 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1112204006859 putative homodimer interface [polypeptide binding]; other site 1112204006860 putative active site pocket [active] 1112204006861 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1112204006862 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1112204006863 Pup-like protein; Region: Pup; cl05289 1112204006864 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1112204006865 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1112204006866 active site 1112204006867 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1112204006868 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1112204006869 active site 1112204006870 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1112204006871 Predicted transcriptional regulator [Transcription]; Region: COG2378 1112204006872 WYL domain; Region: WYL; pfam13280 1112204006873 Predicted transcriptional regulator [Transcription]; Region: COG2378 1112204006874 WYL domain; Region: WYL; pfam13280 1112204006875 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1112204006876 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1112204006877 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1112204006878 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1112204006879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204006880 ATP binding site [chemical binding]; other site 1112204006881 putative Mg++ binding site [ion binding]; other site 1112204006882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204006883 nucleotide binding region [chemical binding]; other site 1112204006884 ATP-binding site [chemical binding]; other site 1112204006885 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1112204006886 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1112204006887 5'-3' exonuclease; Region: 53EXOc; smart00475 1112204006888 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1112204006889 active site 1112204006890 metal binding site 1 [ion binding]; metal-binding site 1112204006891 putative 5' ssDNA interaction site; other site 1112204006892 metal binding site 3; metal-binding site 1112204006893 metal binding site 2 [ion binding]; metal-binding site 1112204006894 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1112204006895 putative DNA binding site [nucleotide binding]; other site 1112204006896 putative metal binding site [ion binding]; other site 1112204006897 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1112204006898 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1112204006899 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1112204006900 active site 1112204006901 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1112204006902 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1112204006903 classical (c) SDRs; Region: SDR_c; cd05233 1112204006904 NAD(P) binding site [chemical binding]; other site 1112204006905 active site 1112204006906 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1112204006907 active site 1112204006908 putative homodimer interface [polypeptide binding]; other site 1112204006909 SAM binding site [chemical binding]; other site 1112204006910 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1112204006911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204006912 S-adenosylmethionine binding site [chemical binding]; other site 1112204006913 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1112204006914 active site 1112204006915 homodimer interface [polypeptide binding]; other site 1112204006916 SAM binding site [chemical binding]; other site 1112204006917 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1112204006918 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1112204006919 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1112204006920 active site 1112204006921 SAM binding site [chemical binding]; other site 1112204006922 homodimer interface [polypeptide binding]; other site 1112204006923 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1112204006924 active site 1112204006925 SAM binding site [chemical binding]; other site 1112204006926 homodimer interface [polypeptide binding]; other site 1112204006927 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1112204006928 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1112204006929 precorrin-3B synthase; Region: CobG; TIGR02435 1112204006930 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1112204006931 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1112204006932 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1112204006933 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1112204006934 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1112204006935 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1112204006936 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1112204006937 active site 1112204006938 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1112204006939 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1112204006940 putative active site [active] 1112204006941 catalytic triad [active] 1112204006942 putative dimer interface [polypeptide binding]; other site 1112204006943 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1112204006944 Ligand binding site; other site 1112204006945 Putative Catalytic site; other site 1112204006946 DXD motif; other site 1112204006947 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1112204006948 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1112204006949 cyclase homology domain; Region: CHD; cd07302 1112204006950 nucleotidyl binding site; other site 1112204006951 metal binding site [ion binding]; metal-binding site 1112204006952 dimer interface [polypeptide binding]; other site 1112204006953 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1112204006954 active site 1112204006955 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204006956 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204006957 active site 1112204006958 PGAP1-like protein; Region: PGAP1; pfam07819 1112204006959 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1112204006960 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204006961 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1112204006962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204006963 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1112204006964 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204006965 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1112204006966 acyl-activating enzyme (AAE) consensus motif; other site 1112204006967 AMP binding site [chemical binding]; other site 1112204006968 active site 1112204006969 CoA binding site [chemical binding]; other site 1112204006970 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1112204006971 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204006972 active site 2 [active] 1112204006973 active site 1 [active] 1112204006974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204006975 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1112204006976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204006977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204006978 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1112204006979 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1112204006980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204006981 Walker A/P-loop; other site 1112204006982 ATP binding site [chemical binding]; other site 1112204006983 Q-loop/lid; other site 1112204006984 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1112204006985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204006986 Walker A/P-loop; other site 1112204006987 ATP binding site [chemical binding]; other site 1112204006988 Q-loop/lid; other site 1112204006989 ABC transporter signature motif; other site 1112204006990 Walker B; other site 1112204006991 D-loop; other site 1112204006992 H-loop/switch region; other site 1112204006993 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1112204006994 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204006995 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1112204006996 Predicted transcriptional regulators [Transcription]; Region: COG1695 1112204006997 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1112204006998 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1112204006999 SnoaL-like domain; Region: SnoaL_2; pfam12680 1112204007000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1112204007001 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1112204007002 Walker A/P-loop; other site 1112204007003 ATP binding site [chemical binding]; other site 1112204007004 Q-loop/lid; other site 1112204007005 ABC transporter signature motif; other site 1112204007006 Walker B; other site 1112204007007 D-loop; other site 1112204007008 H-loop/switch region; other site 1112204007009 Histidine kinase; Region: HisKA_3; pfam07730 1112204007010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204007011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204007012 active site 1112204007013 phosphorylation site [posttranslational modification] 1112204007014 intermolecular recognition site; other site 1112204007015 dimerization interface [polypeptide binding]; other site 1112204007016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204007017 DNA binding residues [nucleotide binding] 1112204007018 dimerization interface [polypeptide binding]; other site 1112204007019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204007020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204007021 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1112204007022 dimerization interface [polypeptide binding]; other site 1112204007023 substrate binding pocket [chemical binding]; other site 1112204007024 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1112204007025 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204007026 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204007027 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1112204007028 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204007029 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204007030 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1112204007031 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1112204007032 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1112204007033 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1112204007034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1112204007035 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1112204007036 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1112204007037 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1112204007038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204007039 active site 1112204007040 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1112204007041 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1112204007042 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1112204007043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204007044 putative substrate translocation pore; other site 1112204007045 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1112204007046 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1112204007047 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1112204007048 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1112204007049 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1112204007050 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1112204007051 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1112204007052 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1112204007053 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1112204007054 active site 1112204007055 FMN binding site [chemical binding]; other site 1112204007056 substrate binding site [chemical binding]; other site 1112204007057 putative catalytic residue [active] 1112204007058 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1112204007059 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1112204007060 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1112204007061 putative active site [active] 1112204007062 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1112204007063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204007064 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1112204007065 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204007066 acyl-activating enzyme (AAE) consensus motif; other site 1112204007067 AMP binding site [chemical binding]; other site 1112204007068 active site 1112204007069 CoA binding site [chemical binding]; other site 1112204007070 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1112204007071 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1112204007072 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1112204007073 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1112204007074 substrate binding site [chemical binding]; other site 1112204007075 dimer interface [polypeptide binding]; other site 1112204007076 ATP binding site [chemical binding]; other site 1112204007077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204007078 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1112204007079 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1112204007080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204007081 dimerization interface [polypeptide binding]; other site 1112204007082 putative DNA binding site [nucleotide binding]; other site 1112204007083 putative Zn2+ binding site [ion binding]; other site 1112204007084 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1112204007085 putative hydrophobic ligand binding site [chemical binding]; other site 1112204007086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204007087 active site 1112204007088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204007089 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1112204007090 active site 1112204007091 motif I; other site 1112204007092 motif II; other site 1112204007093 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1112204007094 LGFP repeat; Region: LGFP; pfam08310 1112204007095 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1112204007096 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1112204007097 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1112204007098 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1112204007099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204007100 Walker A/P-loop; other site 1112204007101 ATP binding site [chemical binding]; other site 1112204007102 Q-loop/lid; other site 1112204007103 ABC transporter signature motif; other site 1112204007104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204007105 ABC transporter; Region: ABC_tran_2; pfam12848 1112204007106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1112204007107 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1112204007108 Emopamil binding protein; Region: EBP; pfam05241 1112204007109 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1112204007110 putative hydrophobic ligand binding site [chemical binding]; other site 1112204007111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204007112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204007113 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1112204007114 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1112204007115 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204007116 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1112204007117 ABC transporter signature motif; other site 1112204007118 Walker B; other site 1112204007119 D-loop; other site 1112204007120 H-loop/switch region; other site 1112204007121 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1112204007122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204007123 putative substrate translocation pore; other site 1112204007124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204007125 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204007126 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1112204007127 RibD C-terminal domain; Region: RibD_C; cl17279 1112204007128 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1112204007129 hydrophobic ligand binding site; other site 1112204007130 RibD C-terminal domain; Region: RibD_C; cl17279 1112204007131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204007132 dimerization interface [polypeptide binding]; other site 1112204007133 putative DNA binding site [nucleotide binding]; other site 1112204007134 putative Zn2+ binding site [ion binding]; other site 1112204007135 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1112204007136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204007137 NAD(P) binding site [chemical binding]; other site 1112204007138 active site 1112204007139 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1112204007140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204007141 Walker A motif; other site 1112204007142 ATP binding site [chemical binding]; other site 1112204007143 Walker B motif; other site 1112204007144 arginine finger; other site 1112204007145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1112204007146 Integrase core domain; Region: rve; pfam00665 1112204007147 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204007148 MULE transposase domain; Region: MULE; pfam10551 1112204007149 putative transposase OrfB; Reviewed; Region: PHA02517 1112204007150 HTH-like domain; Region: HTH_21; pfam13276 1112204007151 Integrase core domain; Region: rve; pfam00665 1112204007152 Integrase core domain; Region: rve_3; pfam13683 1112204007153 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204007154 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 1112204007155 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1112204007156 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1112204007157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204007158 putative substrate translocation pore; other site 1112204007159 SnoaL-like domain; Region: SnoaL_2; pfam12680 1112204007160 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204007161 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204007162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1112204007163 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1112204007164 DNA-binding site [nucleotide binding]; DNA binding site 1112204007165 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1112204007166 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1112204007167 Flavodoxin; Region: Flavodoxin_1; pfam00258 1112204007168 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1112204007169 FAD binding pocket [chemical binding]; other site 1112204007170 conserved FAD binding motif [chemical binding]; other site 1112204007171 phosphate binding motif [ion binding]; other site 1112204007172 beta-alpha-beta structure motif; other site 1112204007173 NAD binding pocket [chemical binding]; other site 1112204007174 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1112204007175 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204007176 classical (c) SDRs; Region: SDR_c; cd05233 1112204007177 NAD(P) binding site [chemical binding]; other site 1112204007178 active site 1112204007179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204007180 Cytochrome P450; Region: p450; cl12078 1112204007181 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1112204007182 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204007183 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204007184 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204007185 enoyl-CoA hydratase; Provisional; Region: PRK06688 1112204007186 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204007187 substrate binding site [chemical binding]; other site 1112204007188 oxyanion hole (OAH) forming residues; other site 1112204007189 trimer interface [polypeptide binding]; other site 1112204007190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204007191 NAD(P) binding site [chemical binding]; other site 1112204007192 active site 1112204007193 enoyl-CoA hydratase; Provisional; Region: PRK08252 1112204007194 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204007195 substrate binding site [chemical binding]; other site 1112204007196 oxyanion hole (OAH) forming residues; other site 1112204007197 trimer interface [polypeptide binding]; other site 1112204007198 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204007199 active site 1112204007200 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204007201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204007202 DNA-binding site [nucleotide binding]; DNA binding site 1112204007203 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1112204007204 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204007205 substrate binding site [chemical binding]; other site 1112204007206 oxyanion hole (OAH) forming residues; other site 1112204007207 trimer interface [polypeptide binding]; other site 1112204007208 enoyl-CoA hydratase; Provisional; Region: PRK06210 1112204007209 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204007210 substrate binding site [chemical binding]; other site 1112204007211 oxyanion hole (OAH) forming residues; other site 1112204007212 trimer interface [polypeptide binding]; other site 1112204007213 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204007214 active site 1112204007215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204007216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204007217 active site 1112204007218 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1112204007219 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1112204007220 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1112204007221 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1112204007222 NAD(P) binding site [chemical binding]; other site 1112204007223 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204007224 active site 2 [active] 1112204007225 active site 1 [active] 1112204007226 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1112204007227 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204007228 CoenzymeA binding site [chemical binding]; other site 1112204007229 subunit interaction site [polypeptide binding]; other site 1112204007230 PHB binding site; other site 1112204007231 AMP-binding enzyme; Region: AMP-binding; pfam00501 1112204007232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204007233 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204007234 acyl-activating enzyme (AAE) consensus motif; other site 1112204007235 acyl-activating enzyme (AAE) consensus motif; other site 1112204007236 AMP binding site [chemical binding]; other site 1112204007237 active site 1112204007238 CoA binding site [chemical binding]; other site 1112204007239 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204007240 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204007241 active site 1112204007242 metabolite-proton symporter; Region: 2A0106; TIGR00883 1112204007243 classical (c) SDRs; Region: SDR_c; cd05233 1112204007244 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1112204007245 NAD(P) binding site [chemical binding]; other site 1112204007246 active site 1112204007247 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1112204007248 short chain dehydrogenase; Provisional; Region: PRK08219 1112204007249 NADP binding site [chemical binding]; other site 1112204007250 substrate binding site [chemical binding]; other site 1112204007251 active site 1112204007252 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204007253 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204007254 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204007255 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204007256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204007257 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204007258 Acylphosphatase; Region: Acylphosphatase; cl00551 1112204007259 classical (c) SDRs; Region: SDR_c; cd05233 1112204007260 NAD(P) binding site [chemical binding]; other site 1112204007261 active site 1112204007262 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1112204007263 active site 1112204007264 catalytic triad [active] 1112204007265 oxyanion hole [active] 1112204007266 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204007267 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1112204007268 DUF35 OB-fold domain; Region: DUF35; pfam01796 1112204007269 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1112204007270 active site 1112204007271 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1112204007272 classical (c) SDRs; Region: SDR_c; cd05233 1112204007273 NAD(P) binding site [chemical binding]; other site 1112204007274 active site 1112204007275 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1112204007276 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204007277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204007278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204007279 acyl-activating enzyme (AAE) consensus motif; other site 1112204007280 acyl-activating enzyme (AAE) consensus motif; other site 1112204007281 AMP binding site [chemical binding]; other site 1112204007282 active site 1112204007283 CoA binding site [chemical binding]; other site 1112204007284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204007285 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1112204007286 NAD(P) binding site [chemical binding]; other site 1112204007287 active site 1112204007288 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204007289 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204007290 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1112204007291 classical (c) SDRs; Region: SDR_c; cd05233 1112204007292 NAD(P) binding site [chemical binding]; other site 1112204007293 active site 1112204007294 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204007295 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204007296 active site 1112204007297 Putative cyclase; Region: Cyclase; pfam04199 1112204007298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204007299 Amidohydrolase; Region: Amidohydro_2; pfam04909 1112204007300 putative CoA-transferase; Provisional; Region: PRK11430 1112204007301 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204007302 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204007303 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204007304 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204007305 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204007306 potential frameshift: common BLAST hit: gi|256826340|ref|YP_003150300.1| DNA replication protein 1112204007307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204007308 Walker A motif; other site 1112204007309 ATP binding site [chemical binding]; other site 1112204007310 Walker B motif; other site 1112204007311 transposase; Provisional; Region: PRK06526 1112204007312 short chain dehydrogenase; Provisional; Region: PRK08263 1112204007313 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1112204007314 NADP binding site [chemical binding]; other site 1112204007315 active site 1112204007316 steroid binding site; other site 1112204007317 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1112204007318 putative catalytic site [active] 1112204007319 putative metal binding site [ion binding]; other site 1112204007320 putative phosphate binding site [ion binding]; other site 1112204007321 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1112204007322 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1112204007323 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1112204007324 putative dimer interface [polypeptide binding]; other site 1112204007325 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204007326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204007327 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1112204007328 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1112204007329 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204007330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204007331 DNA binding residues [nucleotide binding] 1112204007332 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1112204007333 Phage integrase family; Region: Phage_integrase; pfam00589 1112204007334 active site 1112204007335 DNA binding site [nucleotide binding] 1112204007336 Int/Topo IB signature motif; other site 1112204007337 Helix-turn-helix domain; Region: HTH_17; pfam12728 1112204007338 AAA domain; Region: AAA_25; pfam13481 1112204007339 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1112204007340 Walker A motif; other site 1112204007341 ATP binding site [chemical binding]; other site 1112204007342 Walker B motif; other site 1112204007343 Phage capsid family; Region: Phage_capsid; pfam05065 1112204007344 GTP-binding protein Der; Reviewed; Region: PRK03003 1112204007345 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1112204007346 G1 box; other site 1112204007347 GTP/Mg2+ binding site [chemical binding]; other site 1112204007348 Switch I region; other site 1112204007349 G2 box; other site 1112204007350 Switch II region; other site 1112204007351 G3 box; other site 1112204007352 G4 box; other site 1112204007353 G5 box; other site 1112204007354 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1112204007355 G1 box; other site 1112204007356 GTP/Mg2+ binding site [chemical binding]; other site 1112204007357 Switch I region; other site 1112204007358 G2 box; other site 1112204007359 G3 box; other site 1112204007360 Switch II region; other site 1112204007361 G4 box; other site 1112204007362 G5 box; other site 1112204007363 cytidylate kinase; Provisional; Region: cmk; PRK00023 1112204007364 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1112204007365 CMP-binding site; other site 1112204007366 The sites determining sugar specificity; other site 1112204007367 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1112204007368 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1112204007369 RNA binding surface [nucleotide binding]; other site 1112204007370 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1112204007371 active site 1112204007372 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1112204007373 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1112204007374 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1112204007375 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1112204007376 P-loop; other site 1112204007377 Magnesium ion binding site [ion binding]; other site 1112204007378 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1112204007379 Magnesium ion binding site [ion binding]; other site 1112204007380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204007381 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1112204007382 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1112204007383 active site 1112204007384 DNA binding site [nucleotide binding] 1112204007385 Int/Topo IB signature motif; other site 1112204007386 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1112204007387 dimer interface [polypeptide binding]; other site 1112204007388 ADP-ribose binding site [chemical binding]; other site 1112204007389 active site 1112204007390 nudix motif; other site 1112204007391 metal binding site [ion binding]; metal-binding site 1112204007392 CTP synthetase; Validated; Region: pyrG; PRK05380 1112204007393 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1112204007394 active site 1112204007395 UTP binding site [chemical binding]; other site 1112204007396 Catalytic site [active] 1112204007397 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1112204007398 active site 1112204007399 putative oxyanion hole; other site 1112204007400 catalytic triad [active] 1112204007401 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1112204007402 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1112204007403 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1112204007404 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1112204007405 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1112204007406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204007407 Walker A/P-loop; other site 1112204007408 ATP binding site [chemical binding]; other site 1112204007409 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1112204007410 ABC transporter signature motif; other site 1112204007411 Walker B; other site 1112204007412 D-loop; other site 1112204007413 H-loop/switch region; other site 1112204007414 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1112204007415 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1112204007416 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1112204007417 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1112204007418 RNA binding surface [nucleotide binding]; other site 1112204007419 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1112204007420 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1112204007421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204007422 motif II; other site 1112204007423 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1112204007424 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1112204007425 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1112204007426 active site 1112204007427 HIGH motif; other site 1112204007428 dimer interface [polypeptide binding]; other site 1112204007429 KMSKS motif; other site 1112204007430 S4 RNA-binding domain; Region: S4; smart00363 1112204007431 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1112204007432 acyl-CoA synthetase; Validated; Region: PRK07868 1112204007433 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204007434 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204007435 acyl-activating enzyme (AAE) consensus motif; other site 1112204007436 AMP binding site [chemical binding]; other site 1112204007437 active site 1112204007438 CoA binding site [chemical binding]; other site 1112204007439 argininosuccinate lyase; Provisional; Region: PRK00855 1112204007440 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1112204007441 active sites [active] 1112204007442 tetramer interface [polypeptide binding]; other site 1112204007443 argininosuccinate synthase; Provisional; Region: PRK13820 1112204007444 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1112204007445 ANP binding site [chemical binding]; other site 1112204007446 Substrate Binding Site II [chemical binding]; other site 1112204007447 Substrate Binding Site I [chemical binding]; other site 1112204007448 arginine repressor; Provisional; Region: PRK03341 1112204007449 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1112204007450 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1112204007451 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1112204007452 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1112204007453 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1112204007454 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1112204007455 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204007456 inhibitor-cofactor binding pocket; inhibition site 1112204007457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204007458 catalytic residue [active] 1112204007459 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1112204007460 feedback inhibition sensing region; other site 1112204007461 homohexameric interface [polypeptide binding]; other site 1112204007462 nucleotide binding site [chemical binding]; other site 1112204007463 N-acetyl-L-glutamate binding site [chemical binding]; other site 1112204007464 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1112204007465 heterotetramer interface [polypeptide binding]; other site 1112204007466 active site pocket [active] 1112204007467 cleavage site 1112204007468 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1112204007469 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1112204007470 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1112204007471 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1112204007472 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1112204007473 putative tRNA-binding site [nucleotide binding]; other site 1112204007474 B3/4 domain; Region: B3_4; pfam03483 1112204007475 tRNA synthetase B5 domain; Region: B5; smart00874 1112204007476 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1112204007477 dimer interface [polypeptide binding]; other site 1112204007478 motif 1; other site 1112204007479 motif 3; other site 1112204007480 motif 2; other site 1112204007481 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1112204007482 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1112204007483 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 1112204007484 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1112204007485 dimer interface [polypeptide binding]; other site 1112204007486 motif 1; other site 1112204007487 active site 1112204007488 motif 2; other site 1112204007489 motif 3; other site 1112204007490 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1112204007491 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1112204007492 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1112204007493 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1112204007494 23S rRNA binding site [nucleotide binding]; other site 1112204007495 L21 binding site [polypeptide binding]; other site 1112204007496 L13 binding site [polypeptide binding]; other site 1112204007497 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1112204007498 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1112204007499 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1112204007500 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1112204007501 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1112204007502 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1112204007503 active site 1112204007504 catalytic triad [active] 1112204007505 dimer interface [polypeptide binding]; other site 1112204007506 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1112204007507 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1112204007508 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1112204007509 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1112204007510 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1112204007511 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1112204007512 Predicted membrane protein [Function unknown]; Region: COG2259 1112204007513 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1112204007514 Part of AAA domain; Region: AAA_19; pfam13245 1112204007515 Family description; Region: UvrD_C_2; pfam13538 1112204007516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204007517 Ligand Binding Site [chemical binding]; other site 1112204007518 excinuclease ABC subunit B; Provisional; Region: PRK05298 1112204007519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204007520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204007521 nucleotide binding region [chemical binding]; other site 1112204007522 ATP-binding site [chemical binding]; other site 1112204007523 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1112204007524 UvrB/uvrC motif; Region: UVR; pfam02151 1112204007525 Protein of unknown function (DUF402); Region: DUF402; cl00979 1112204007526 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1112204007527 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1112204007528 CoA-binding site [chemical binding]; other site 1112204007529 ATP-binding [chemical binding]; other site 1112204007530 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1112204007531 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1112204007532 RNA binding site [nucleotide binding]; other site 1112204007533 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1112204007534 RNA binding site [nucleotide binding]; other site 1112204007535 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1112204007536 RNA binding site [nucleotide binding]; other site 1112204007537 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1112204007538 RNA binding site [nucleotide binding]; other site 1112204007539 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1112204007540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204007541 S-adenosylmethionine binding site [chemical binding]; other site 1112204007542 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1112204007543 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1112204007544 Walker A/P-loop; other site 1112204007545 ATP binding site [chemical binding]; other site 1112204007546 Q-loop/lid; other site 1112204007547 ABC transporter signature motif; other site 1112204007548 Walker B; other site 1112204007549 D-loop; other site 1112204007550 H-loop/switch region; other site 1112204007551 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1112204007552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204007553 dimer interface [polypeptide binding]; other site 1112204007554 conserved gate region; other site 1112204007555 putative PBP binding loops; other site 1112204007556 ABC-ATPase subunit interface; other site 1112204007557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1112204007558 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1112204007559 substrate binding pocket [chemical binding]; other site 1112204007560 membrane-bound complex binding site; other site 1112204007561 hinge residues; other site 1112204007562 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1112204007563 tartrate dehydrogenase; Provisional; Region: PRK08194 1112204007564 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204007565 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1112204007566 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1112204007567 active site 1112204007568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204007569 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1112204007570 DNA polymerase I; Provisional; Region: PRK05755 1112204007571 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1112204007572 active site 1112204007573 metal binding site 1 [ion binding]; metal-binding site 1112204007574 putative 5' ssDNA interaction site; other site 1112204007575 metal binding site 3; metal-binding site 1112204007576 metal binding site 2 [ion binding]; metal-binding site 1112204007577 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1112204007578 putative DNA binding site [nucleotide binding]; other site 1112204007579 putative metal binding site [ion binding]; other site 1112204007580 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1112204007581 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1112204007582 active site 1112204007583 DNA binding site [nucleotide binding] 1112204007584 catalytic site [active] 1112204007585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1112204007586 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1112204007587 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1112204007588 Walker A/P-loop; other site 1112204007589 ATP binding site [chemical binding]; other site 1112204007590 Q-loop/lid; other site 1112204007591 ABC transporter signature motif; other site 1112204007592 Walker B; other site 1112204007593 D-loop; other site 1112204007594 H-loop/switch region; other site 1112204007595 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1112204007596 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1112204007597 Walker A/P-loop; other site 1112204007598 ATP binding site [chemical binding]; other site 1112204007599 Q-loop/lid; other site 1112204007600 ABC transporter signature motif; other site 1112204007601 Walker B; other site 1112204007602 D-loop; other site 1112204007603 H-loop/switch region; other site 1112204007604 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1112204007605 TM-ABC transporter signature motif; other site 1112204007606 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1112204007607 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1112204007608 TM-ABC transporter signature motif; other site 1112204007609 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1112204007610 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1112204007611 dimerization interface [polypeptide binding]; other site 1112204007612 ligand binding site [chemical binding]; other site 1112204007613 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1112204007614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204007615 active site 1112204007616 phosphorylation site [posttranslational modification] 1112204007617 intermolecular recognition site; other site 1112204007618 dimerization interface [polypeptide binding]; other site 1112204007619 ANTAR domain; Region: ANTAR; pfam03861 1112204007620 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1112204007621 DNA methylase; Region: N6_N4_Mtase; pfam01555 1112204007622 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1112204007623 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1112204007624 active site 1112204007625 DNA binding site [nucleotide binding] 1112204007626 Int/Topo IB signature motif; other site 1112204007627 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1112204007628 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1112204007629 catalytic residues [active] 1112204007630 catalytic nucleophile [active] 1112204007631 Presynaptic Site I dimer interface [polypeptide binding]; other site 1112204007632 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1112204007633 Synaptic Flat tetramer interface [polypeptide binding]; other site 1112204007634 Synaptic Site I dimer interface [polypeptide binding]; other site 1112204007635 DNA binding site [nucleotide binding] 1112204007636 Recombinase; Region: Recombinase; pfam07508 1112204007637 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1112204007638 putative transposase OrfB; Reviewed; Region: PHA02517 1112204007639 HTH-like domain; Region: HTH_21; pfam13276 1112204007640 Integrase core domain; Region: rve; pfam00665 1112204007641 Integrase core domain; Region: rve_3; pfam13683 1112204007642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1112204007643 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1112204007644 polymerase nucleotide-binding site; other site 1112204007645 DNA-binding residues [nucleotide binding]; DNA binding site 1112204007646 nucleotide binding site [chemical binding]; other site 1112204007647 primase nucleotide-binding site [nucleotide binding]; other site 1112204007648 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204007649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204007650 non-specific DNA binding site [nucleotide binding]; other site 1112204007651 salt bridge; other site 1112204007652 sequence-specific DNA binding site [nucleotide binding]; other site 1112204007653 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204007654 CoenzymeA binding site [chemical binding]; other site 1112204007655 subunit interaction site [polypeptide binding]; other site 1112204007656 PHB binding site; other site 1112204007657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204007658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204007659 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1112204007660 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1112204007661 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1112204007662 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1112204007663 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1112204007664 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1112204007665 amidase; Validated; Region: PRK06565 1112204007666 Amidase; Region: Amidase; cl11426 1112204007667 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1112204007668 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1112204007669 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1112204007670 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1112204007671 Cupin superfamily protein; Region: Cupin_4; pfam08007 1112204007672 Cupin-like domain; Region: Cupin_8; pfam13621 1112204007673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1112204007674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204007675 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1112204007676 Walker A motif; other site 1112204007677 ATP binding site [chemical binding]; other site 1112204007678 Walker B motif; other site 1112204007679 arginine finger; other site 1112204007680 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1112204007681 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1112204007682 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204007683 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204007684 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204007685 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1112204007686 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1112204007687 active site 1112204007688 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1112204007689 active site 1112204007690 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1112204007691 tetramer interface [polypeptide binding]; other site 1112204007692 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1112204007693 hypothetical protein; Provisional; Region: PRK04233 1112204007694 SEC-C motif; Region: SEC-C; pfam02810 1112204007695 short chain dehydrogenase; Provisional; Region: PRK06940 1112204007696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204007697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204007698 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1112204007699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204007700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204007701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204007702 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1112204007703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204007704 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204007705 DNA binding residues [nucleotide binding] 1112204007706 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1112204007707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1112204007708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204007709 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1112204007710 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1112204007711 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1112204007712 acyl-activating enzyme (AAE) consensus motif; other site 1112204007713 putative AMP binding site [chemical binding]; other site 1112204007714 putative active site [active] 1112204007715 putative CoA binding site [chemical binding]; other site 1112204007716 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1112204007717 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1112204007718 active site 1112204007719 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1112204007720 catalytic triad [active] 1112204007721 dimer interface [polypeptide binding]; other site 1112204007722 pyruvate kinase; Provisional; Region: PRK06247 1112204007723 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1112204007724 domain interfaces; other site 1112204007725 active site 1112204007726 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1112204007727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204007728 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1112204007729 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1112204007730 active site 1112204007731 dimer interface [polypeptide binding]; other site 1112204007732 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1112204007733 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1112204007734 active site 1112204007735 FMN binding site [chemical binding]; other site 1112204007736 substrate binding site [chemical binding]; other site 1112204007737 3Fe-4S cluster binding site [ion binding]; other site 1112204007738 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1112204007739 domain interface; other site 1112204007740 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 1112204007741 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1112204007742 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1112204007743 substrate binding site [chemical binding]; other site 1112204007744 active site 1112204007745 catalytic residues [active] 1112204007746 heterodimer interface [polypeptide binding]; other site 1112204007747 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1112204007748 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1112204007749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204007750 catalytic residue [active] 1112204007751 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1112204007752 active site 1112204007753 ribulose/triose binding site [chemical binding]; other site 1112204007754 phosphate binding site [ion binding]; other site 1112204007755 substrate (anthranilate) binding pocket [chemical binding]; other site 1112204007756 product (indole) binding pocket [chemical binding]; other site 1112204007757 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1112204007758 anthranilate synthase component I; Provisional; Region: PRK13571 1112204007759 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1112204007760 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1112204007761 Tautomerase enzyme; Region: Tautomerase; pfam01361 1112204007762 active site 1 [active] 1112204007763 dimer interface [polypeptide binding]; other site 1112204007764 hexamer interface [polypeptide binding]; other site 1112204007765 active site 2 [active] 1112204007766 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1112204007767 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1112204007768 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1112204007769 substrate binding site [chemical binding]; other site 1112204007770 glutamase interaction surface [polypeptide binding]; other site 1112204007771 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1112204007772 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1112204007773 active site 1112204007774 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1112204007775 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1112204007776 catalytic residues [active] 1112204007777 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1112204007778 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1112204007779 putative active site [active] 1112204007780 oxyanion strand; other site 1112204007781 catalytic triad [active] 1112204007782 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1112204007783 putative active site pocket [active] 1112204007784 4-fold oligomerization interface [polypeptide binding]; other site 1112204007785 metal binding residues [ion binding]; metal-binding site 1112204007786 3-fold/trimer interface [polypeptide binding]; other site 1112204007787 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1112204007788 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204007789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204007790 homodimer interface [polypeptide binding]; other site 1112204007791 catalytic residue [active] 1112204007792 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1112204007793 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1112204007794 NAD binding site [chemical binding]; other site 1112204007795 dimerization interface [polypeptide binding]; other site 1112204007796 product binding site; other site 1112204007797 substrate binding site [chemical binding]; other site 1112204007798 zinc binding site [ion binding]; other site 1112204007799 catalytic residues [active] 1112204007800 Predicted esterase [General function prediction only]; Region: COG0627 1112204007801 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1112204007802 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1112204007803 active site 1112204007804 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204007805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204007806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204007807 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1112204007808 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1112204007809 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204007810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204007811 NAD(P) binding site [chemical binding]; other site 1112204007812 active site 1112204007813 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1112204007814 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1112204007815 dimerization interface [polypeptide binding]; other site 1112204007816 active site 1112204007817 quinolinate synthetase; Provisional; Region: PRK09375 1112204007818 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204007819 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204007820 DNA binding residues [nucleotide binding] 1112204007821 dimerization interface [polypeptide binding]; other site 1112204007822 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1112204007823 biotin synthase; Validated; Region: PRK06256 1112204007824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204007825 FeS/SAM binding site; other site 1112204007826 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1112204007827 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1112204007828 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1112204007829 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1112204007830 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204007831 catalytic residue [active] 1112204007832 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1112204007833 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204007834 inhibitor-cofactor binding pocket; inhibition site 1112204007835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204007836 catalytic residue [active] 1112204007837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204007838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204007839 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1112204007840 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1112204007841 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1112204007842 active site 1112204007843 catalytic site [active] 1112204007844 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1112204007845 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1112204007846 active site 1112204007847 catalytic site [active] 1112204007848 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204007849 mce related protein; Region: MCE; pfam02470 1112204007850 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204007851 mce related protein; Region: MCE; pfam02470 1112204007852 mce related protein; Region: MCE; pfam02470 1112204007853 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204007854 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204007855 mce related protein; Region: MCE; pfam02470 1112204007856 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204007857 mce related protein; Region: MCE; pfam02470 1112204007858 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204007859 mce related protein; Region: MCE; pfam02470 1112204007860 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204007861 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1112204007862 Permease; Region: Permease; pfam02405 1112204007863 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1112204007864 Permease; Region: Permease; pfam02405 1112204007865 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1112204007866 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1112204007867 catalytic site [active] 1112204007868 active site 1112204007869 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1112204007870 threonine dehydratase; Validated; Region: PRK08639 1112204007871 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1112204007872 tetramer interface [polypeptide binding]; other site 1112204007873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204007874 catalytic residue [active] 1112204007875 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1112204007876 putative Ile/Val binding site [chemical binding]; other site 1112204007877 Ion channel; Region: Ion_trans_2; pfam07885 1112204007878 TrkA-N domain; Region: TrkA_N; pfam02254 1112204007879 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1112204007880 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1112204007881 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1112204007882 active site 1112204007883 PHP Thumb interface [polypeptide binding]; other site 1112204007884 metal binding site [ion binding]; metal-binding site 1112204007885 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1112204007886 generic binding surface II; other site 1112204007887 generic binding surface I; other site 1112204007888 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1112204007889 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1112204007890 active site 1112204007891 lipoprotein signal peptidase; Provisional; Region: PRK14764 1112204007892 lipoprotein signal peptidase; Provisional; Region: PRK14787 1112204007893 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1112204007894 active site 1112204007895 homodimer interface [polypeptide binding]; other site 1112204007896 homotetramer interface [polypeptide binding]; other site 1112204007897 DNA polymerase IV; Provisional; Region: PRK03348 1112204007898 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1112204007899 active site 1112204007900 DNA binding site [nucleotide binding] 1112204007901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204007902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204007903 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204007904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204007905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204007906 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204007907 MarR family; Region: MarR_2; pfam12802 1112204007908 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1112204007909 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1112204007910 HIGH motif; other site 1112204007911 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1112204007912 active site 1112204007913 KMSKS motif; other site 1112204007914 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1112204007915 tRNA binding surface [nucleotide binding]; other site 1112204007916 anticodon binding site; other site 1112204007917 DivIVA domain; Region: DivI1A_domain; TIGR03544 1112204007918 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1112204007919 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1112204007920 Protein of unknown function (DUF552); Region: DUF552; cl00775 1112204007921 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1112204007922 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1112204007923 catalytic residue [active] 1112204007924 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1112204007925 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1112204007926 cell division protein FtsZ; Validated; Region: PRK09330 1112204007927 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1112204007928 nucleotide binding site [chemical binding]; other site 1112204007929 SulA interaction site; other site 1112204007930 cell division protein FtsQ; Provisional; Region: PRK05529 1112204007931 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1112204007932 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1112204007933 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1112204007934 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1112204007935 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1112204007936 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1112204007937 active site 1112204007938 homodimer interface [polypeptide binding]; other site 1112204007939 cell division protein FtsW; Region: ftsW; TIGR02614 1112204007940 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1112204007941 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1112204007942 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1112204007943 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1112204007944 Mg++ binding site [ion binding]; other site 1112204007945 putative catalytic motif [active] 1112204007946 putative substrate binding site [chemical binding]; other site 1112204007947 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1112204007948 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1112204007949 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1112204007950 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1112204007951 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1112204007952 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1112204007953 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1112204007954 MraW methylase family; Region: Methyltransf_5; cl17771 1112204007955 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1112204007956 MraZ protein; Region: MraZ; pfam02381 1112204007957 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1112204007958 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1112204007959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1112204007960 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1112204007961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204007962 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1112204007963 FAD binding site [chemical binding]; other site 1112204007964 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1112204007965 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1112204007966 substrate binding pocket [chemical binding]; other site 1112204007967 chain length determination region; other site 1112204007968 substrate-Mg2+ binding site; other site 1112204007969 catalytic residues [active] 1112204007970 aspartate-rich region 1; other site 1112204007971 active site lid residues [active] 1112204007972 aspartate-rich region 2; other site 1112204007973 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1112204007974 Helix-turn-helix domain; Region: HTH_17; pfam12728 1112204007975 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204007976 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204007977 active site 1112204007978 ATP binding site [chemical binding]; other site 1112204007979 substrate binding site [chemical binding]; other site 1112204007980 activation loop (A-loop); other site 1112204007981 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1112204007982 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1112204007983 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1112204007984 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1112204007985 putative acyl-acceptor binding pocket; other site 1112204007986 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1112204007987 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1112204007988 nucleotide binding site [chemical binding]; other site 1112204007989 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1112204007990 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204007991 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1112204007992 putative hydrophobic ligand binding site [chemical binding]; other site 1112204007993 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1112204007994 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1112204007995 acyl-activating enzyme (AAE) consensus motif; other site 1112204007996 putative AMP binding site [chemical binding]; other site 1112204007997 putative active site [active] 1112204007998 putative CoA binding site [chemical binding]; other site 1112204007999 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1112204008000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204008001 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1112204008002 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1112204008003 NlpC/P60 family; Region: NLPC_P60; pfam00877 1112204008004 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1112204008005 NlpC/P60 family; Region: NLPC_P60; pfam00877 1112204008006 hypothetical protein; Validated; Region: PRK07883 1112204008007 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1112204008008 active site 1112204008009 catalytic site [active] 1112204008010 substrate binding site [chemical binding]; other site 1112204008011 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1112204008012 GIY-YIG motif/motif A; other site 1112204008013 active site 1112204008014 catalytic site [active] 1112204008015 putative DNA binding site [nucleotide binding]; other site 1112204008016 metal binding site [ion binding]; metal-binding site 1112204008017 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204008018 AsnC family; Region: AsnC_trans_reg; pfam01037 1112204008019 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1112204008020 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1112204008021 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1112204008022 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1112204008023 Subunit I/III interface [polypeptide binding]; other site 1112204008024 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1112204008025 Cytochrome c; Region: Cytochrom_C; pfam00034 1112204008026 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1112204008027 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1112204008028 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1112204008029 iron-sulfur cluster [ion binding]; other site 1112204008030 [2Fe-2S] cluster binding site [ion binding]; other site 1112204008031 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1112204008032 heme bH binding site [chemical binding]; other site 1112204008033 intrachain domain interface; other site 1112204008034 heme bL binding site [chemical binding]; other site 1112204008035 interchain domain interface [polypeptide binding]; other site 1112204008036 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1112204008037 Qo binding site; other site 1112204008038 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1112204008039 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1112204008040 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1112204008041 active site 1112204008042 catalytic site [active] 1112204008043 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1112204008044 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1112204008045 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1112204008046 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1112204008047 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1112204008048 dimer interface [polypeptide binding]; other site 1112204008049 active site 1112204008050 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1112204008051 Ligand Binding Site [chemical binding]; other site 1112204008052 Molecular Tunnel; other site 1112204008053 Src homology 2 (SH2) domain; Region: SH2; cl15255 1112204008054 phosphotyrosine binding pocket [polypeptide binding]; other site 1112204008055 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1112204008056 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1112204008057 substrate binding site [chemical binding]; other site 1112204008058 ATP binding site [chemical binding]; other site 1112204008059 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1112204008060 Glycerate kinase family; Region: Gly_kinase; cl00841 1112204008061 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1112204008062 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1112204008063 homotrimer interface [polypeptide binding]; other site 1112204008064 Walker A motif; other site 1112204008065 GTP binding site [chemical binding]; other site 1112204008066 Walker B motif; other site 1112204008067 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1112204008068 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1112204008069 putative dimer interface [polypeptide binding]; other site 1112204008070 active site pocket [active] 1112204008071 putative cataytic base [active] 1112204008072 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1112204008073 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1112204008074 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1112204008075 homodimer interface [polypeptide binding]; other site 1112204008076 substrate-cofactor binding pocket; other site 1112204008077 catalytic residue [active] 1112204008078 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1112204008079 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1112204008080 Putative amidase domain; Region: Amidase_6; pfam12671 1112204008081 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1112204008082 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1112204008083 interface (dimer of trimers) [polypeptide binding]; other site 1112204008084 Substrate-binding/catalytic site; other site 1112204008085 Zn-binding sites [ion binding]; other site 1112204008086 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1112204008087 E3 interaction surface; other site 1112204008088 lipoyl attachment site [posttranslational modification]; other site 1112204008089 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1112204008090 E3 interaction surface; other site 1112204008091 lipoyl attachment site [posttranslational modification]; other site 1112204008092 e3 binding domain; Region: E3_binding; pfam02817 1112204008093 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1112204008094 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1112204008095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204008096 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1112204008097 NAD(P) binding site [chemical binding]; other site 1112204008098 active site 1112204008099 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1112204008100 lipoyl synthase; Provisional; Region: PRK05481 1112204008101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204008102 FeS/SAM binding site; other site 1112204008103 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1112204008104 RDD family; Region: RDD; pfam06271 1112204008105 glutamine synthetase, type I; Region: GlnA; TIGR00653 1112204008106 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1112204008107 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1112204008108 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1112204008109 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1112204008110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204008111 putative substrate translocation pore; other site 1112204008112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204008113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204008114 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1112204008115 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1112204008116 heme binding pocket [chemical binding]; other site 1112204008117 heme ligand [chemical binding]; other site 1112204008118 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1112204008119 putative catalytic site [active] 1112204008120 putative phosphate binding site [ion binding]; other site 1112204008121 putative metal binding site [ion binding]; other site 1112204008122 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1112204008123 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1112204008124 metal binding triad; other site 1112204008125 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1112204008126 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1112204008127 metal binding triad; other site 1112204008128 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1112204008129 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1112204008130 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1112204008131 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1112204008132 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1112204008133 oligomerization interface [polypeptide binding]; other site 1112204008134 active site 1112204008135 metal binding site [ion binding]; metal-binding site 1112204008136 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1112204008137 TAP-like protein; Region: Abhydrolase_4; pfam08386 1112204008138 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1112204008139 putative active site; other site 1112204008140 putative metal binding residues [ion binding]; other site 1112204008141 signature motif; other site 1112204008142 putative triphosphate binding site [ion binding]; other site 1112204008143 CHAD domain; Region: CHAD; pfam05235 1112204008144 RNB domain; Region: RNB; pfam00773 1112204008145 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1112204008146 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1112204008147 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204008148 catalytic core [active] 1112204008149 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1112204008150 Putative zinc ribbon domain; Region: DUF164; pfam02591 1112204008151 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1112204008152 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1112204008153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1112204008154 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1112204008155 hypothetical protein; Provisional; Region: PRK07908 1112204008156 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204008157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204008158 catalytic residue [active] 1112204008159 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1112204008160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204008161 motif II; other site 1112204008162 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1112204008163 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1112204008164 active site 1112204008165 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1112204008166 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204008167 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204008168 active site 1112204008169 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1112204008170 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1112204008171 catalytic triad [active] 1112204008172 active site nucleophile [active] 1112204008173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204008174 S-adenosylmethionine binding site [chemical binding]; other site 1112204008175 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1112204008176 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1112204008177 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1112204008178 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204008179 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204008180 active site 1112204008181 ATP binding site [chemical binding]; other site 1112204008182 substrate binding site [chemical binding]; other site 1112204008183 activation loop (A-loop); other site 1112204008184 Predicted transcriptional regulator [Transcription]; Region: COG2378 1112204008185 HTH domain; Region: HTH_11; pfam08279 1112204008186 WYL domain; Region: WYL; pfam13280 1112204008187 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1112204008188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204008189 NAD(P) binding site [chemical binding]; other site 1112204008190 active site 1112204008191 CAAX protease self-immunity; Region: Abi; pfam02517 1112204008192 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1112204008193 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1112204008194 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1112204008195 homodimer interface [polypeptide binding]; other site 1112204008196 NADP binding site [chemical binding]; other site 1112204008197 substrate binding site [chemical binding]; other site 1112204008198 AAA domain; Region: AAA_17; pfam13207 1112204008199 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 1112204008200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1112204008201 Protein kinase domain; Region: Pkinase; pfam00069 1112204008202 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204008203 substrate binding site [chemical binding]; other site 1112204008204 activation loop (A-loop); other site 1112204008205 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008206 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008207 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008208 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204008209 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008210 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008211 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204008212 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204008213 active site 1112204008214 ATP binding site [chemical binding]; other site 1112204008215 substrate binding site [chemical binding]; other site 1112204008216 activation loop (A-loop); other site 1112204008217 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1112204008218 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008219 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008220 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008221 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204008222 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204008223 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1112204008224 active site 1112204008225 catalytic triad [active] 1112204008226 oxyanion hole [active] 1112204008227 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1112204008228 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1112204008229 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1112204008230 catalytic triad [active] 1112204008231 catalytic triad [active] 1112204008232 oxyanion hole [active] 1112204008233 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1112204008234 active site 1112204008235 catalytic triad [active] 1112204008236 oxyanion hole [active] 1112204008237 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1112204008238 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1112204008239 dimer interface [polypeptide binding]; other site 1112204008240 catalytic triad [active] 1112204008241 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1112204008242 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1112204008243 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1112204008244 dimer interface [polypeptide binding]; other site 1112204008245 TPP-binding site [chemical binding]; other site 1112204008246 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1112204008247 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204008248 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1112204008249 acyl carrier protein; Provisional; Region: acpP; PRK00982 1112204008250 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1112204008251 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1112204008252 dimer interface [polypeptide binding]; other site 1112204008253 active site 1112204008254 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1112204008255 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1112204008256 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1112204008257 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1112204008258 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1112204008259 Beta-lactamase; Region: Beta-lactamase; pfam00144 1112204008260 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1112204008261 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1112204008262 NAD binding site [chemical binding]; other site 1112204008263 catalytic Zn binding site [ion binding]; other site 1112204008264 substrate binding site [chemical binding]; other site 1112204008265 structural Zn binding site [ion binding]; other site 1112204008266 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1112204008267 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204008268 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204008269 acyl-activating enzyme (AAE) consensus motif; other site 1112204008270 acyl-activating enzyme (AAE) consensus motif; other site 1112204008271 putative AMP binding site [chemical binding]; other site 1112204008272 putative active site [active] 1112204008273 putative CoA binding site [chemical binding]; other site 1112204008274 enoyl-CoA hydratase; Provisional; Region: PRK06688 1112204008275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204008276 substrate binding site [chemical binding]; other site 1112204008277 oxyanion hole (OAH) forming residues; other site 1112204008278 trimer interface [polypeptide binding]; other site 1112204008279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204008280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204008281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204008282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204008283 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204008284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204008285 DNA-binding site [nucleotide binding]; DNA binding site 1112204008286 FCD domain; Region: FCD; pfam07729 1112204008287 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1112204008288 Helix-turn-helix domain; Region: HTH_17; pfam12728 1112204008289 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1112204008290 Helix-turn-helix domain; Region: HTH_38; pfam13936 1112204008291 Integrase core domain; Region: rve; pfam00665 1112204008292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1112204008293 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1112204008294 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1112204008295 active site 1112204008296 Int/Topo IB signature motif; other site 1112204008297 DNA binding site [nucleotide binding] 1112204008298 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1112204008299 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1112204008300 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1112204008301 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1112204008302 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1112204008303 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1112204008304 putative acyl-acceptor binding pocket; other site 1112204008305 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1112204008306 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1112204008307 putative acyl-acceptor binding pocket; other site 1112204008308 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1112204008309 DNA primase; Validated; Region: dnaG; PRK05667 1112204008310 CHC2 zinc finger; Region: zf-CHC2; cl17510 1112204008311 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1112204008312 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1112204008313 active site 1112204008314 metal binding site [ion binding]; metal-binding site 1112204008315 interdomain interaction site; other site 1112204008316 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1112204008317 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1112204008318 PE-PPE domain; Region: PE-PPE; pfam08237 1112204008319 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1112204008320 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1112204008321 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1112204008322 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1112204008323 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1112204008324 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1112204008325 Zn2+ binding site [ion binding]; other site 1112204008326 Mg2+ binding site [ion binding]; other site 1112204008327 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1112204008328 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1112204008329 DNA-binding site [nucleotide binding]; DNA binding site 1112204008330 RNA-binding motif; other site 1112204008331 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1112204008332 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1112204008333 motif 1; other site 1112204008334 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1112204008335 active site 1112204008336 motif 2; other site 1112204008337 motif 3; other site 1112204008338 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1112204008339 anticodon binding site; other site 1112204008340 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204008341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204008342 dimerization interface [polypeptide binding]; other site 1112204008343 putative DNA binding site [nucleotide binding]; other site 1112204008344 putative Zn2+ binding site [ion binding]; other site 1112204008345 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1112204008346 metal binding site 2 [ion binding]; metal-binding site 1112204008347 putative DNA binding helix; other site 1112204008348 metal binding site 1 [ion binding]; metal-binding site 1112204008349 dimer interface [polypeptide binding]; other site 1112204008350 structural Zn2+ binding site [ion binding]; other site 1112204008351 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1112204008352 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1112204008353 catalytic residue [active] 1112204008354 putative FPP diphosphate binding site; other site 1112204008355 putative FPP binding hydrophobic cleft; other site 1112204008356 dimer interface [polypeptide binding]; other site 1112204008357 putative IPP diphosphate binding site; other site 1112204008358 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1112204008359 Recombination protein O N terminal; Region: RecO_N; pfam11967 1112204008360 Recombination protein O C terminal; Region: RecO_C; pfam02565 1112204008361 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1112204008362 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1112204008363 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1112204008364 GTPase Era; Reviewed; Region: era; PRK00089 1112204008365 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1112204008366 G1 box; other site 1112204008367 GTP/Mg2+ binding site [chemical binding]; other site 1112204008368 Switch I region; other site 1112204008369 G2 box; other site 1112204008370 Switch II region; other site 1112204008371 G3 box; other site 1112204008372 G4 box; other site 1112204008373 G5 box; other site 1112204008374 KH domain; Region: KH_2; pfam07650 1112204008375 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1112204008376 active site 1112204008377 Domain of unknown function DUF21; Region: DUF21; pfam01595 1112204008378 FOG: CBS domain [General function prediction only]; Region: COG0517 1112204008379 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1112204008380 Transporter associated domain; Region: CorC_HlyC; smart01091 1112204008381 metal-binding heat shock protein; Provisional; Region: PRK00016 1112204008382 PhoH-like protein; Region: PhoH; pfam02562 1112204008383 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1112204008384 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1112204008385 thioester formation/cholesterol transfer; other site 1112204008386 PhoH-like protein; Region: PhoH; pfam02562 1112204008387 SnoaL-like domain; Region: SnoaL_2; pfam12680 1112204008388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204008389 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204008390 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1112204008391 chaperone protein DnaJ; Provisional; Region: PRK14278 1112204008392 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1112204008393 HSP70 interaction site [polypeptide binding]; other site 1112204008394 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1112204008395 Zn binding sites [ion binding]; other site 1112204008396 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1112204008397 dimer interface [polypeptide binding]; other site 1112204008398 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1112204008399 HTH domain; Region: HTH_11; cl17392 1112204008400 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1112204008401 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 1112204008402 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1112204008403 multimer interface [polypeptide binding]; other site 1112204008404 active site 1112204008405 catalytic triad [active] 1112204008406 dimer interface [polypeptide binding]; other site 1112204008407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204008408 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1112204008409 Walker A motif; other site 1112204008410 ATP binding site [chemical binding]; other site 1112204008411 Walker B motif; other site 1112204008412 arginine finger; other site 1112204008413 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1112204008414 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1112204008415 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1112204008416 putative ligand binding site [chemical binding]; other site 1112204008417 MarR family; Region: MarR_2; pfam12802 1112204008418 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1112204008419 HemN C-terminal domain; Region: HemN_C; pfam06969 1112204008420 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1112204008421 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1112204008422 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1112204008423 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1112204008424 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1112204008425 Active Sites [active] 1112204008426 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1112204008427 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1112204008428 Active Sites [active] 1112204008429 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1112204008430 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1112204008431 CysD dimerization site [polypeptide binding]; other site 1112204008432 G1 box; other site 1112204008433 putative GEF interaction site [polypeptide binding]; other site 1112204008434 GTP/Mg2+ binding site [chemical binding]; other site 1112204008435 Switch I region; other site 1112204008436 G2 box; other site 1112204008437 G3 box; other site 1112204008438 Switch II region; other site 1112204008439 G4 box; other site 1112204008440 G5 box; other site 1112204008441 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1112204008442 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1112204008443 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1112204008444 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1112204008445 putative active site [active] 1112204008446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204008447 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1112204008448 Walker A/P-loop; other site 1112204008449 ATP binding site [chemical binding]; other site 1112204008450 Q-loop/lid; other site 1112204008451 ABC transporter signature motif; other site 1112204008452 Walker B; other site 1112204008453 D-loop; other site 1112204008454 H-loop/switch region; other site 1112204008455 TOBE domain; Region: TOBE_2; pfam08402 1112204008456 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1112204008457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204008458 dimer interface [polypeptide binding]; other site 1112204008459 conserved gate region; other site 1112204008460 putative PBP binding loops; other site 1112204008461 ABC-ATPase subunit interface; other site 1112204008462 sulfate transport protein; Provisional; Region: cysT; CHL00187 1112204008463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204008464 dimer interface [polypeptide binding]; other site 1112204008465 conserved gate region; other site 1112204008466 putative PBP binding loops; other site 1112204008467 ABC-ATPase subunit interface; other site 1112204008468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1112204008469 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1112204008470 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1112204008471 Cation efflux family; Region: Cation_efflux; cl00316 1112204008472 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1112204008473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204008474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204008475 catalytic residue [active] 1112204008476 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1112204008477 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1112204008478 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1112204008479 active site 1112204008480 Zn binding site [ion binding]; other site 1112204008481 GTP-binding protein LepA; Provisional; Region: PRK05433 1112204008482 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1112204008483 G1 box; other site 1112204008484 putative GEF interaction site [polypeptide binding]; other site 1112204008485 GTP/Mg2+ binding site [chemical binding]; other site 1112204008486 Switch I region; other site 1112204008487 G2 box; other site 1112204008488 G3 box; other site 1112204008489 Switch II region; other site 1112204008490 G4 box; other site 1112204008491 G5 box; other site 1112204008492 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1112204008493 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1112204008494 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1112204008495 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1112204008496 PemK-like protein; Region: PemK; pfam02452 1112204008497 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1112204008498 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1112204008499 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1112204008500 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1112204008501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1112204008502 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1112204008503 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1112204008504 hypothetical protein; Reviewed; Region: PRK07914 1112204008505 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1112204008506 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1112204008507 Competence protein; Region: Competence; pfam03772 1112204008508 Helix-hairpin-helix motif; Region: HHH; pfam00633 1112204008509 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1112204008510 EDD domain protein, DegV family; Region: DegV; TIGR00762 1112204008511 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1112204008512 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1112204008513 active site 1112204008514 catalytic triad [active] 1112204008515 oxyanion hole [active] 1112204008516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204008517 catalytic core [active] 1112204008518 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1112204008519 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1112204008520 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1112204008521 active site 1112204008522 (T/H)XGH motif; other site 1112204008523 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1112204008524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204008525 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1112204008526 Walker A motif; other site 1112204008527 ATP binding site [chemical binding]; other site 1112204008528 Walker B motif; other site 1112204008529 arginine finger; other site 1112204008530 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1112204008531 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1112204008532 putative catalytic cysteine [active] 1112204008533 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1112204008534 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1112204008535 Moco binding site; other site 1112204008536 metal coordination site [ion binding]; other site 1112204008537 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1112204008538 Fasciclin domain; Region: Fasciclin; pfam02469 1112204008539 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1112204008540 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1112204008541 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1112204008542 generic binding surface II; other site 1112204008543 ssDNA binding site; other site 1112204008544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204008545 ATP binding site [chemical binding]; other site 1112204008546 putative Mg++ binding site [ion binding]; other site 1112204008547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204008548 nucleotide binding region [chemical binding]; other site 1112204008549 ATP-binding site [chemical binding]; other site 1112204008550 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1112204008551 DAK2 domain; Region: Dak2; pfam02734 1112204008552 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1112204008553 enoyl-CoA hydratase; Provisional; Region: PRK06688 1112204008554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204008555 substrate binding site [chemical binding]; other site 1112204008556 oxyanion hole (OAH) forming residues; other site 1112204008557 trimer interface [polypeptide binding]; other site 1112204008558 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1112204008559 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1112204008560 FMN binding site [chemical binding]; other site 1112204008561 dimer interface [polypeptide binding]; other site 1112204008562 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1112204008563 ligand binding site [chemical binding]; other site 1112204008564 active site 1112204008565 UGI interface [polypeptide binding]; other site 1112204008566 catalytic site [active] 1112204008567 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1112204008568 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1112204008569 trimer interface [polypeptide binding]; other site 1112204008570 putative metal binding site [ion binding]; other site 1112204008571 thiamine monophosphate kinase; Provisional; Region: PRK05731 1112204008572 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1112204008573 ATP binding site [chemical binding]; other site 1112204008574 dimerization interface [polypeptide binding]; other site 1112204008575 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1112204008576 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1112204008577 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1112204008578 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1112204008579 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1112204008580 polyphosphate kinase; Provisional; Region: PRK05443 1112204008581 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1112204008582 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1112204008583 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1112204008584 putative domain interface [polypeptide binding]; other site 1112204008585 putative active site [active] 1112204008586 catalytic site [active] 1112204008587 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1112204008588 putative domain interface [polypeptide binding]; other site 1112204008589 putative active site [active] 1112204008590 catalytic site [active] 1112204008591 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1112204008592 active site 1112204008593 Ap6A binding site [chemical binding]; other site 1112204008594 nudix motif; other site 1112204008595 metal binding site [ion binding]; metal-binding site 1112204008596 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204008597 catalytic core [active] 1112204008598 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1112204008599 IHF - DNA interface [nucleotide binding]; other site 1112204008600 IHF dimer interface [polypeptide binding]; other site 1112204008601 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1112204008602 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1112204008603 substrate binding site [chemical binding]; other site 1112204008604 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1112204008605 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1112204008606 substrate binding site [chemical binding]; other site 1112204008607 ligand binding site [chemical binding]; other site 1112204008608 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1112204008609 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204008610 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204008611 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1112204008612 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1112204008613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1112204008614 active site 1112204008615 HIGH motif; other site 1112204008616 nucleotide binding site [chemical binding]; other site 1112204008617 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1112204008618 active site 1112204008619 KMSKS motif; other site 1112204008620 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204008621 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1112204008622 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1112204008623 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1112204008624 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1112204008625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204008626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204008627 putative substrate translocation pore; other site 1112204008628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204008629 DNA-binding site [nucleotide binding]; DNA binding site 1112204008630 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1112204008631 tartrate dehydrogenase; Region: TTC; TIGR02089 1112204008632 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1112204008633 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1112204008634 ligand binding site [chemical binding]; other site 1112204008635 NAD binding site [chemical binding]; other site 1112204008636 dimerization interface [polypeptide binding]; other site 1112204008637 catalytic site [active] 1112204008638 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1112204008639 putative L-serine binding site [chemical binding]; other site 1112204008640 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1112204008641 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1112204008642 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1112204008643 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1112204008644 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1112204008645 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1112204008646 putative valine binding site [chemical binding]; other site 1112204008647 dimer interface [polypeptide binding]; other site 1112204008648 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1112204008649 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1112204008650 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1112204008651 PYR/PP interface [polypeptide binding]; other site 1112204008652 dimer interface [polypeptide binding]; other site 1112204008653 TPP binding site [chemical binding]; other site 1112204008654 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1112204008655 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1112204008656 TPP-binding site [chemical binding]; other site 1112204008657 dimer interface [polypeptide binding]; other site 1112204008658 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1112204008659 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1112204008660 DoxX; Region: DoxX; pfam07681 1112204008661 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1112204008662 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1112204008663 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1112204008664 GatB domain; Region: GatB_Yqey; smart00845 1112204008665 PspC domain; Region: PspC; pfam04024 1112204008666 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1112204008667 phosphofructokinase; Region: PFK_mixed; TIGR02483 1112204008668 active site 1112204008669 ADP/pyrophosphate binding site [chemical binding]; other site 1112204008670 dimerization interface [polypeptide binding]; other site 1112204008671 allosteric effector site; other site 1112204008672 fructose-1,6-bisphosphate binding site; other site 1112204008673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204008674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204008675 active site 1112204008676 phosphorylation site [posttranslational modification] 1112204008677 intermolecular recognition site; other site 1112204008678 dimerization interface [polypeptide binding]; other site 1112204008679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204008680 DNA binding residues [nucleotide binding] 1112204008681 dimerization interface [polypeptide binding]; other site 1112204008682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1112204008683 Histidine kinase; Region: HisKA_3; pfam07730 1112204008684 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1112204008685 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1112204008686 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1112204008687 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1112204008688 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1112204008689 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1112204008690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1112204008691 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1112204008692 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1112204008693 putative ADP-ribose binding site [chemical binding]; other site 1112204008694 putative active site [active] 1112204008695 SnoaL-like domain; Region: SnoaL_2; pfam12680 1112204008696 short chain dehydrogenase; Provisional; Region: PRK12744 1112204008697 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1112204008698 NADP binding site [chemical binding]; other site 1112204008699 homodimer interface [polypeptide binding]; other site 1112204008700 active site 1112204008701 substrate binding site [chemical binding]; other site 1112204008702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204008703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204008704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204008705 dimerization interface [polypeptide binding]; other site 1112204008706 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1112204008707 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1112204008708 nucleotide binding pocket [chemical binding]; other site 1112204008709 K-X-D-G motif; other site 1112204008710 catalytic site [active] 1112204008711 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1112204008712 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1112204008713 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1112204008714 Dimer interface [polypeptide binding]; other site 1112204008715 BRCT sequence motif; other site 1112204008716 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204008717 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204008718 active site 1112204008719 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1112204008720 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1112204008721 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1112204008722 conserved cys residue [active] 1112204008723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204008724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204008725 putative sialic acid transporter; Region: 2A0112; TIGR00891 1112204008726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204008727 putative substrate translocation pore; other site 1112204008728 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1112204008729 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1112204008730 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1112204008731 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1112204008732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204008733 catalytic residue [active] 1112204008734 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204008735 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1112204008736 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1112204008737 DNA binding site [nucleotide binding] 1112204008738 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1112204008739 AAA ATPase domain; Region: AAA_16; pfam13191 1112204008740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204008741 putative substrate translocation pore; other site 1112204008742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204008743 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204008744 GXWXG protein; Region: GXWXG; pfam14231 1112204008745 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1112204008746 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1112204008747 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1112204008748 putative acyl-acceptor binding pocket; other site 1112204008749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1112204008750 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1112204008751 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1112204008752 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1112204008753 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1112204008754 Ligand binding site [chemical binding]; other site 1112204008755 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1112204008756 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1112204008757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204008758 S-adenosylmethionine binding site [chemical binding]; other site 1112204008759 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1112204008760 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1112204008761 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1112204008762 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1112204008763 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1112204008764 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1112204008765 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1112204008766 trimer interface [polypeptide binding]; other site 1112204008767 active site 1112204008768 substrate binding site [chemical binding]; other site 1112204008769 CoA binding site [chemical binding]; other site 1112204008770 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1112204008771 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1112204008772 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1112204008773 conserved cys residue [active] 1112204008774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204008775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204008776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204008777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204008778 putative substrate translocation pore; other site 1112204008779 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1112204008780 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1112204008781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204008782 S-adenosylmethionine binding site [chemical binding]; other site 1112204008783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204008784 enoyl-CoA hydratase; Provisional; Region: PRK05862 1112204008785 substrate binding site [chemical binding]; other site 1112204008786 oxyanion hole (OAH) forming residues; other site 1112204008787 trimer interface [polypeptide binding]; other site 1112204008788 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1112204008789 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1112204008790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204008791 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1112204008792 nucleotide binding site [chemical binding]; other site 1112204008793 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1112204008794 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1112204008795 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1112204008796 NUDIX domain; Region: NUDIX; pfam00293 1112204008797 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1112204008798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204008799 Walker A/P-loop; other site 1112204008800 ATP binding site [chemical binding]; other site 1112204008801 Q-loop/lid; other site 1112204008802 ABC transporter signature motif; other site 1112204008803 Walker B; other site 1112204008804 D-loop; other site 1112204008805 H-loop/switch region; other site 1112204008806 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1112204008807 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204008808 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1112204008809 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1112204008810 dimer interface [polypeptide binding]; other site 1112204008811 putative active site [active] 1112204008812 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1112204008813 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1112204008814 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1112204008815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204008816 motif II; other site 1112204008817 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1112204008818 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1112204008819 D-pathway; other site 1112204008820 Putative ubiquinol binding site [chemical binding]; other site 1112204008821 Low-spin heme (heme b) binding site [chemical binding]; other site 1112204008822 Putative water exit pathway; other site 1112204008823 Binuclear center (heme o3/CuB) [ion binding]; other site 1112204008824 K-pathway; other site 1112204008825 Putative proton exit pathway; other site 1112204008826 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1112204008827 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1112204008828 intersubunit interface [polypeptide binding]; other site 1112204008829 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1112204008830 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1112204008831 tetramer interface [polypeptide binding]; other site 1112204008832 active site 1112204008833 Mg2+/Mn2+ binding site [ion binding]; other site 1112204008834 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1112204008835 active site clefts [active] 1112204008836 zinc binding site [ion binding]; other site 1112204008837 dimer interface [polypeptide binding]; other site 1112204008838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1112204008839 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1112204008840 SNF2 Helicase protein; Region: DUF3670; pfam12419 1112204008841 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1112204008842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204008843 ATP binding site [chemical binding]; other site 1112204008844 putative Mg++ binding site [ion binding]; other site 1112204008845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204008846 nucleotide binding region [chemical binding]; other site 1112204008847 ATP-binding site [chemical binding]; other site 1112204008848 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1112204008849 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1112204008850 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1112204008851 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1112204008852 dimer interface [polypeptide binding]; other site 1112204008853 putative radical transfer pathway; other site 1112204008854 diiron center [ion binding]; other site 1112204008855 tyrosyl radical; other site 1112204008856 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1112204008857 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1112204008858 SCP-2 sterol transfer family; Region: SCP2; cl01225 1112204008859 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1112204008860 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1112204008861 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1112204008862 active site 1112204008863 dimer interface [polypeptide binding]; other site 1112204008864 catalytic residues [active] 1112204008865 effector binding site; other site 1112204008866 R2 peptide binding site; other site 1112204008867 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1112204008868 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1112204008869 catalytic residues [active] 1112204008870 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1112204008871 Predicted flavoprotein [General function prediction only]; Region: COG0431 1112204008872 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1112204008873 hypothetical protein; Provisional; Region: PRK07236 1112204008874 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1112204008875 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1112204008876 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1112204008877 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1112204008878 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1112204008879 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1112204008880 Transcription factor WhiB; Region: Whib; pfam02467 1112204008881 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1112204008882 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1112204008883 dimer interface [polypeptide binding]; other site 1112204008884 phosphate binding site [ion binding]; other site 1112204008885 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1112204008886 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1112204008887 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 1112204008888 FMN binding site [chemical binding]; other site 1112204008889 dimer interface [polypeptide binding]; other site 1112204008890 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1112204008891 nudix motif; other site 1112204008892 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1112204008893 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1112204008894 ligand binding site; other site 1112204008895 oligomer interface; other site 1112204008896 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1112204008897 dimer interface [polypeptide binding]; other site 1112204008898 N-terminal domain interface [polypeptide binding]; other site 1112204008899 sulfate 1 binding site; other site 1112204008900 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1112204008901 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1112204008902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204008903 S-adenosylmethionine binding site [chemical binding]; other site 1112204008904 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1112204008905 DivIVA domain; Region: DivI1A_domain; TIGR03544 1112204008906 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1112204008907 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1112204008908 Ligand binding site; other site 1112204008909 Putative Catalytic site; other site 1112204008910 DXD motif; other site 1112204008911 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1112204008912 dihydropteroate synthase; Region: DHPS; TIGR01496 1112204008913 substrate binding pocket [chemical binding]; other site 1112204008914 dimer interface [polypeptide binding]; other site 1112204008915 inhibitor binding site; inhibition site 1112204008916 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1112204008917 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1112204008918 acyl-activating enzyme (AAE) consensus motif; other site 1112204008919 putative AMP binding site [chemical binding]; other site 1112204008920 putative active site [active] 1112204008921 putative CoA binding site [chemical binding]; other site 1112204008922 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1112204008923 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1112204008924 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1112204008925 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1112204008926 metal binding site [ion binding]; metal-binding site 1112204008927 putative dimer interface [polypeptide binding]; other site 1112204008928 Electron transfer DM13; Region: DM13; pfam10517 1112204008929 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1112204008930 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1112204008931 putative trimer interface [polypeptide binding]; other site 1112204008932 putative CoA binding site [chemical binding]; other site 1112204008933 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204008934 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204008935 active site 1112204008936 metal binding site [ion binding]; metal-binding site 1112204008937 Helix-turn-helix domain; Region: HTH_18; pfam12833 1112204008938 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1112204008939 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204008940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204008941 homodimer interface [polypeptide binding]; other site 1112204008942 catalytic residue [active] 1112204008943 Ferredoxin [Energy production and conversion]; Region: COG1146 1112204008944 4Fe-4S binding domain; Region: Fer4; pfam00037 1112204008945 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1112204008946 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1112204008947 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1112204008948 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Region: F420_cofG; TIGR03550 1112204008949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204008950 FeS/SAM binding site; other site 1112204008951 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204008952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204008953 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 1112204008954 GDA1/CD39 (nucleoside phosphatase) family; Region: GDA1_CD39; cl17763 1112204008955 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 1112204008956 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1112204008957 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1112204008958 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1112204008959 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1112204008960 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1112204008961 G1 box; other site 1112204008962 putative GEF interaction site [polypeptide binding]; other site 1112204008963 GTP/Mg2+ binding site [chemical binding]; other site 1112204008964 Switch I region; other site 1112204008965 G2 box; other site 1112204008966 G3 box; other site 1112204008967 Switch II region; other site 1112204008968 G4 box; other site 1112204008969 G5 box; other site 1112204008970 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1112204008971 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1112204008972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204008973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204008974 WHG domain; Region: WHG; pfam13305 1112204008975 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1112204008976 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1112204008977 putative acyl-acceptor binding pocket; other site 1112204008978 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1112204008979 active site 1112204008980 8-oxo-dGMP binding site [chemical binding]; other site 1112204008981 nudix motif; other site 1112204008982 metal binding site [ion binding]; metal-binding site 1112204008983 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1112204008984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204008985 Walker A/P-loop; other site 1112204008986 ATP binding site [chemical binding]; other site 1112204008987 Q-loop/lid; other site 1112204008988 ABC transporter signature motif; other site 1112204008989 Walker B; other site 1112204008990 D-loop; other site 1112204008991 H-loop/switch region; other site 1112204008992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1112204008993 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1112204008994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204008995 dimer interface [polypeptide binding]; other site 1112204008996 conserved gate region; other site 1112204008997 putative PBP binding loops; other site 1112204008998 ABC-ATPase subunit interface; other site 1112204008999 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1112204009000 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1112204009001 Secretory lipase; Region: LIP; pfam03583 1112204009002 YhhN-like protein; Region: YhhN; cl01505 1112204009003 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1112204009004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009005 putative substrate translocation pore; other site 1112204009006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009007 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1112204009008 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1112204009009 CsbD-like; Region: CsbD; pfam05532 1112204009010 Asp23 family; Region: Asp23; pfam03780 1112204009011 Asp23 family; Region: Asp23; pfam03780 1112204009012 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1112204009013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204009014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204009015 DNA binding residues [nucleotide binding] 1112204009016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204009017 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1112204009018 active site 1112204009019 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1112204009020 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1112204009021 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204009022 enoyl-CoA hydratase; Validated; Region: PRK08139 1112204009023 substrate binding site [chemical binding]; other site 1112204009024 oxyanion hole (OAH) forming residues; other site 1112204009025 trimer interface [polypeptide binding]; other site 1112204009026 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1112204009027 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1112204009028 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1112204009029 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1112204009030 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1112204009031 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1112204009032 MarR family; Region: MarR_2; pfam12802 1112204009033 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1112204009034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009035 putative substrate translocation pore; other site 1112204009036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204009037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204009038 active site 1112204009039 phosphorylation site [posttranslational modification] 1112204009040 intermolecular recognition site; other site 1112204009041 dimerization interface [polypeptide binding]; other site 1112204009042 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204009043 DNA binding residues [nucleotide binding] 1112204009044 dimerization interface [polypeptide binding]; other site 1112204009045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1112204009046 Histidine kinase; Region: HisKA_3; pfam07730 1112204009047 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1112204009048 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1112204009049 Walker A/P-loop; other site 1112204009050 ATP binding site [chemical binding]; other site 1112204009051 Q-loop/lid; other site 1112204009052 ABC transporter signature motif; other site 1112204009053 Walker B; other site 1112204009054 D-loop; other site 1112204009055 H-loop/switch region; other site 1112204009056 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1112204009057 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1112204009058 protein binding site [polypeptide binding]; other site 1112204009059 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1112204009060 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1112204009061 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204009062 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1112204009063 active site 1112204009064 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1112204009065 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204009066 active site 1112204009067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204009068 Helix-turn-helix domain; Region: HTH_18; pfam12833 1112204009069 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204009070 Cytochrome P450; Region: p450; cl12078 1112204009071 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204009072 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1112204009073 catalytic loop [active] 1112204009074 iron binding site [ion binding]; other site 1112204009075 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1112204009076 FAD binding pocket [chemical binding]; other site 1112204009077 conserved FAD binding motif [chemical binding]; other site 1112204009078 phosphate binding motif [ion binding]; other site 1112204009079 beta-alpha-beta structure motif; other site 1112204009080 NAD binding pocket [chemical binding]; other site 1112204009081 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204009082 active site 1112204009083 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1112204009084 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1112204009085 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204009086 active site 1112204009087 RibD C-terminal domain; Region: RibD_C; cl17279 1112204009088 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1112204009089 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1112204009090 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1112204009091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204009092 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1112204009093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204009094 dimerization interface [polypeptide binding]; other site 1112204009095 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1112204009096 active site 1112204009097 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1112204009098 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1112204009099 putative NAD(P) binding site [chemical binding]; other site 1112204009100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204009101 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204009102 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204009103 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204009104 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204009105 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204009106 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1112204009107 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1112204009108 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1112204009109 catalytic residues [active] 1112204009110 catalytic nucleophile [active] 1112204009111 Recombinase; Region: Recombinase; pfam07508 1112204009112 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1112204009113 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1112204009114 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1112204009115 Presynaptic Site I dimer interface [polypeptide binding]; other site 1112204009116 catalytic residues [active] 1112204009117 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1112204009118 Synaptic Flat tetramer interface [polypeptide binding]; other site 1112204009119 Synaptic Site I dimer interface [polypeptide binding]; other site 1112204009120 DNA binding site [nucleotide binding] 1112204009121 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1112204009122 DNA-binding interface [nucleotide binding]; DNA binding site 1112204009123 Domain of unknown function (DUF955); Region: DUF955; cl01076 1112204009124 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1112204009125 GTP-binding protein YchF; Reviewed; Region: PRK09601 1112204009126 YchF GTPase; Region: YchF; cd01900 1112204009127 G1 box; other site 1112204009128 GTP/Mg2+ binding site [chemical binding]; other site 1112204009129 Switch I region; other site 1112204009130 G2 box; other site 1112204009131 Switch II region; other site 1112204009132 G3 box; other site 1112204009133 G4 box; other site 1112204009134 G5 box; other site 1112204009135 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1112204009136 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1112204009137 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1112204009138 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1112204009139 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1112204009140 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1112204009141 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1112204009142 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1112204009143 minor groove reading motif; other site 1112204009144 helix-hairpin-helix signature motif; other site 1112204009145 substrate binding pocket [chemical binding]; other site 1112204009146 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1112204009147 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1112204009148 DNA binding site [nucleotide binding] 1112204009149 active site 1112204009150 RmuC family; Region: RmuC; pfam02646 1112204009151 nucleosidase; Provisional; Region: PRK05634 1112204009152 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1112204009153 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1112204009154 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204009155 short chain dehydrogenase; Provisional; Region: PRK07832 1112204009156 classical (c) SDRs; Region: SDR_c; cd05233 1112204009157 NAD(P) binding site [chemical binding]; other site 1112204009158 active site 1112204009159 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1112204009160 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1112204009161 active site 1112204009162 metal binding site [ion binding]; metal-binding site 1112204009163 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1112204009164 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1112204009165 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1112204009166 rhodanese superfamily protein; Provisional; Region: PRK05320 1112204009167 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1112204009168 active site residue [active] 1112204009169 Lsr2; Region: Lsr2; pfam11774 1112204009170 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1112204009171 catalytic residues [active] 1112204009172 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1112204009173 active site 1112204009174 DNA binding site [nucleotide binding] 1112204009175 Int/Topo IB signature motif; other site 1112204009176 Helix-turn-helix domain; Region: HTH_17; pfam12728 1112204009177 AAA domain; Region: AAA_25; pfam13481 1112204009178 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1112204009179 putative hydrophobic ligand binding site [chemical binding]; other site 1112204009180 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1112204009181 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1112204009182 active site 1112204009183 non-prolyl cis peptide bond; other site 1112204009184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204009185 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1112204009186 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1112204009187 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204009188 DNA binding residues [nucleotide binding] 1112204009189 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1112204009190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204009191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204009192 homodimer interface [polypeptide binding]; other site 1112204009193 catalytic residue [active] 1112204009194 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1112204009195 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204009196 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1112204009197 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204009198 active site 1112204009199 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1112204009200 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1112204009201 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1112204009202 active site 1112204009203 DNA binding site [nucleotide binding] 1112204009204 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1112204009205 active site 1112204009206 catalytic residues [active] 1112204009207 galactokinase; Provisional; Region: PRK00555 1112204009208 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1112204009209 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1112204009210 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1112204009211 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1112204009212 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1112204009213 dimer interface [polypeptide binding]; other site 1112204009214 active site 1112204009215 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1112204009216 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1112204009217 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1112204009218 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1112204009219 Na binding site [ion binding]; other site 1112204009220 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204009221 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204009222 hypothetical protein; Provisional; Region: PRK07945 1112204009223 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1112204009224 active site 1112204009225 phosphoglucomutase; Validated; Region: PRK07564 1112204009226 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1112204009227 active site 1112204009228 substrate binding site [chemical binding]; other site 1112204009229 metal binding site [ion binding]; metal-binding site 1112204009230 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1112204009231 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1112204009232 nucleophilic elbow; other site 1112204009233 catalytic triad; other site 1112204009234 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1112204009235 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1112204009236 acyl-activating enzyme (AAE) consensus motif; other site 1112204009237 putative AMP binding site [chemical binding]; other site 1112204009238 putative active site [active] 1112204009239 putative CoA binding site [chemical binding]; other site 1112204009240 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204009241 mce related protein; Region: MCE; pfam02470 1112204009242 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204009243 mce related protein; Region: MCE; pfam02470 1112204009244 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204009245 mce related protein; Region: MCE; pfam02470 1112204009246 mce related protein; Region: MCE; pfam02470 1112204009247 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204009248 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204009249 mce related protein; Region: MCE; pfam02470 1112204009250 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1112204009251 mce related protein; Region: MCE; pfam02470 1112204009252 Permease; Region: Permease; pfam02405 1112204009253 Permease; Region: Permease; pfam02405 1112204009254 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204009255 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204009256 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1112204009257 active site 1112204009258 catalytic residues [active] 1112204009259 metal binding site [ion binding]; metal-binding site 1112204009260 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1112204009261 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1112204009262 active site 1112204009263 catalytic residues [active] 1112204009264 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1112204009265 putative transposase OrfB; Reviewed; Region: PHA02517 1112204009266 HTH-like domain; Region: HTH_21; pfam13276 1112204009267 Integrase core domain; Region: rve; pfam00665 1112204009268 Integrase core domain; Region: rve_3; pfam13683 1112204009269 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1112204009270 EspG family; Region: ESX-1_EspG; pfam14011 1112204009271 PPE family; Region: PPE; pfam00823 1112204009272 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1112204009273 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1112204009274 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1112204009275 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1112204009276 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1112204009277 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1112204009278 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1112204009279 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1112204009280 EspG family; Region: ESX-1_EspG; pfam14011 1112204009281 PPE family; Region: PPE; pfam00823 1112204009282 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1112204009283 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1112204009284 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1112204009285 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1112204009286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204009287 Walker A motif; other site 1112204009288 ATP binding site [chemical binding]; other site 1112204009289 Walker B motif; other site 1112204009290 arginine finger; other site 1112204009291 alpha-galactosidase; Region: PLN02808; cl17638 1112204009292 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1112204009293 SmpB-tmRNA interface; other site 1112204009294 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1112204009295 FtsX-like permease family; Region: FtsX; pfam02687 1112204009296 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1112204009297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204009298 Walker A/P-loop; other site 1112204009299 ATP binding site [chemical binding]; other site 1112204009300 Q-loop/lid; other site 1112204009301 ABC transporter signature motif; other site 1112204009302 Walker B; other site 1112204009303 D-loop; other site 1112204009304 H-loop/switch region; other site 1112204009305 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1112204009306 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1112204009307 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1112204009308 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1112204009309 RF-1 domain; Region: RF-1; pfam00472 1112204009310 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1112204009311 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1112204009312 active site 1112204009313 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204009314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204009315 active site 1112204009316 metal binding site [ion binding]; metal-binding site 1112204009317 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204009318 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204009319 active site 1112204009320 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1112204009321 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1112204009322 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204009323 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204009324 active site 1112204009325 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204009326 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204009327 active site 1112204009328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009329 putative substrate translocation pore; other site 1112204009330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204009331 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204009332 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1112204009333 NAD(P) binding site [chemical binding]; other site 1112204009334 catalytic residues [active] 1112204009335 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1112204009336 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1112204009337 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1112204009338 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1112204009339 tetramer interface [polypeptide binding]; other site 1112204009340 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1112204009341 tetramer interface [polypeptide binding]; other site 1112204009342 active site 1112204009343 metal binding site [ion binding]; metal-binding site 1112204009344 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1112204009345 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1112204009346 NAD binding site [chemical binding]; other site 1112204009347 catalytic residues [active] 1112204009348 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204009349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204009350 DNA-binding site [nucleotide binding]; DNA binding site 1112204009351 FCD domain; Region: FCD; pfam07729 1112204009352 hypothetical protein; Provisional; Region: PRK12764 1112204009353 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1112204009354 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1112204009355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009356 metabolite-proton symporter; Region: 2A0106; TIGR00883 1112204009357 putative substrate translocation pore; other site 1112204009358 phenol 2-monooxygenase; Provisional; Region: PRK08294 1112204009359 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1112204009360 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1112204009361 dimer interface [polypeptide binding]; other site 1112204009362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204009363 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1112204009364 tyramine oxidase; Provisional; Region: tynA; PRK11504 1112204009365 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1112204009366 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1112204009367 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204009368 ornithine cyclodeaminase; Validated; Region: PRK06199 1112204009369 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1112204009370 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1112204009371 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1112204009372 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1112204009373 hypothetical protein; Provisional; Region: PRK08266 1112204009374 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1112204009375 PYR/PP interface [polypeptide binding]; other site 1112204009376 dimer interface [polypeptide binding]; other site 1112204009377 TPP binding site [chemical binding]; other site 1112204009378 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1112204009379 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1112204009380 TPP-binding site [chemical binding]; other site 1112204009381 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204009382 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1112204009383 putative DNA binding site [nucleotide binding]; other site 1112204009384 putative Zn2+ binding site [ion binding]; other site 1112204009385 AsnC family; Region: AsnC_trans_reg; pfam01037 1112204009386 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1112204009387 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1112204009388 amidohydrolase; Region: amidohydrolases; TIGR01891 1112204009389 metal binding site [ion binding]; metal-binding site 1112204009390 putative dimer interface [polypeptide binding]; other site 1112204009391 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1112204009392 CrcB-like protein; Region: CRCB; pfam02537 1112204009393 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1112204009394 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204009395 acyl-activating enzyme (AAE) consensus motif; other site 1112204009396 AMP binding site [chemical binding]; other site 1112204009397 active site 1112204009398 CoA binding site [chemical binding]; other site 1112204009399 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1112204009400 Lsr2; Region: Lsr2; pfam11774 1112204009401 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1112204009402 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1112204009403 active site 1112204009404 substrate binding site [chemical binding]; other site 1112204009405 metal binding site [ion binding]; metal-binding site 1112204009406 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1112204009407 hypothetical protein; Validated; Region: PRK00068 1112204009408 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1112204009409 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1112204009410 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1112204009411 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1112204009412 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1112204009413 ABC1 family; Region: ABC1; pfam03109 1112204009414 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1112204009415 active site 1112204009416 ATP binding site [chemical binding]; other site 1112204009417 Helix-turn-helix domain; Region: HTH_18; pfam12833 1112204009418 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1112204009419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204009420 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1112204009421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204009422 S-adenosylmethionine binding site [chemical binding]; other site 1112204009423 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1112204009424 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1112204009425 Family description; Region: UvrD_C_2; pfam13538 1112204009426 HRDC domain; Region: HRDC; pfam00570 1112204009427 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1112204009428 catalytic residues [active] 1112204009429 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1112204009430 DinB superfamily; Region: DinB_2; pfam12867 1112204009431 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1112204009432 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1112204009433 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1112204009434 putative NADH binding site [chemical binding]; other site 1112204009435 putative active site [active] 1112204009436 nudix motif; other site 1112204009437 putative metal binding site [ion binding]; other site 1112204009438 Ion channel; Region: Ion_trans_2; pfam07885 1112204009439 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1112204009440 TrkA-N domain; Region: TrkA_N; pfam02254 1112204009441 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1112204009442 Part of AAA domain; Region: AAA_19; pfam13245 1112204009443 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1112204009444 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1112204009445 Part of AAA domain; Region: AAA_19; pfam13245 1112204009446 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1112204009447 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1112204009448 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204009449 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1112204009450 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1112204009451 catalytic site [active] 1112204009452 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1112204009453 active site 1112204009454 DNA binding site [nucleotide binding] 1112204009455 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1112204009456 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1112204009457 putative active site [active] 1112204009458 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1112204009459 active site 1112204009460 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1112204009461 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1112204009462 active site 1112204009463 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1112204009464 DNA binding site [nucleotide binding] 1112204009465 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1112204009466 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1112204009467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204009468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204009469 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1112204009470 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1112204009471 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1112204009472 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1112204009473 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204009474 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204009475 active site 1112204009476 TIGR02569 family protein; Region: TIGR02569_actnb 1112204009477 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1112204009478 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1112204009479 ATP binding site [chemical binding]; other site 1112204009480 substrate interface [chemical binding]; other site 1112204009481 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1112204009482 active site residue [active] 1112204009483 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1112204009484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204009485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204009486 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1112204009487 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1112204009488 dinuclear metal binding motif [ion binding]; other site 1112204009489 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1112204009490 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1112204009491 ATP binding site [chemical binding]; other site 1112204009492 Mg++ binding site [ion binding]; other site 1112204009493 motif III; other site 1112204009494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204009495 nucleotide binding region [chemical binding]; other site 1112204009496 ATP-binding site [chemical binding]; other site 1112204009497 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1112204009498 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204009499 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1112204009500 Magnesium ion binding site [ion binding]; other site 1112204009501 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1112204009502 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1112204009503 Transcription factor WhiB; Region: Whib; pfam02467 1112204009504 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1112204009505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1112204009506 Histidine kinase; Region: HisKA_2; pfam07568 1112204009507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204009508 ATP binding site [chemical binding]; other site 1112204009509 Mg2+ binding site [ion binding]; other site 1112204009510 G-X-G motif; other site 1112204009511 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1112204009512 carboxyltransferase (CT) interaction site; other site 1112204009513 biotinylation site [posttranslational modification]; other site 1112204009514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009515 metabolite-proton symporter; Region: 2A0106; TIGR00883 1112204009516 putative substrate translocation pore; other site 1112204009517 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1112204009518 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1112204009519 ligand binding site [chemical binding]; other site 1112204009520 flexible hinge region; other site 1112204009521 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1112204009522 non-specific DNA interactions [nucleotide binding]; other site 1112204009523 DNA binding site [nucleotide binding] 1112204009524 sequence specific DNA binding site [nucleotide binding]; other site 1112204009525 putative cAMP binding site [chemical binding]; other site 1112204009526 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1112204009527 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1112204009528 active site 1112204009529 non-prolyl cis peptide bond; other site 1112204009530 SnoaL-like domain; Region: SnoaL_4; pfam13577 1112204009531 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1112204009532 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1112204009533 dimer interface [polypeptide binding]; other site 1112204009534 PYR/PP interface [polypeptide binding]; other site 1112204009535 TPP binding site [chemical binding]; other site 1112204009536 substrate binding site [chemical binding]; other site 1112204009537 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1112204009538 TPP-binding site [chemical binding]; other site 1112204009539 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1112204009540 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1112204009541 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1112204009542 active site 1112204009543 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1112204009544 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1112204009545 ligand binding site [chemical binding]; other site 1112204009546 NAD binding site [chemical binding]; other site 1112204009547 dimerization interface [polypeptide binding]; other site 1112204009548 catalytic site [active] 1112204009549 hypothetical protein; Validated; Region: PRK06201 1112204009550 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1112204009551 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204009552 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1112204009553 Enoylreductase; Region: PKS_ER; smart00829 1112204009554 putative NAD(P) binding site [chemical binding]; other site 1112204009555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204009556 NAD(P) binding site [chemical binding]; other site 1112204009557 active site 1112204009558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204009559 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1112204009560 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1112204009561 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1112204009562 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1112204009563 FAD binding pocket [chemical binding]; other site 1112204009564 FAD binding motif [chemical binding]; other site 1112204009565 phosphate binding motif [ion binding]; other site 1112204009566 NAD binding pocket [chemical binding]; other site 1112204009567 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1112204009568 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1112204009569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204009570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204009571 DNA binding residues [nucleotide binding] 1112204009572 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204009573 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1112204009574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204009575 catalytic residue [active] 1112204009576 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1112204009577 putative deacylase active site [active] 1112204009578 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1112204009579 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1112204009580 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1112204009581 putative NAD(P) binding site [chemical binding]; other site 1112204009582 putative substrate binding site [chemical binding]; other site 1112204009583 catalytic Zn binding site [ion binding]; other site 1112204009584 structural Zn binding site [ion binding]; other site 1112204009585 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204009586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204009587 hypothetical protein; Provisional; Region: PRK06849 1112204009588 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204009589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204009590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009591 putative substrate translocation pore; other site 1112204009592 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1112204009593 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1112204009594 Isochorismatase family; Region: Isochorismatase; pfam00857 1112204009595 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1112204009596 catalytic triad [active] 1112204009597 conserved cis-peptide bond; other site 1112204009598 metabolite-proton symporter; Region: 2A0106; TIGR00883 1112204009599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009600 putative substrate translocation pore; other site 1112204009601 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1112204009602 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204009603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204009604 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1112204009605 NAD(P) binding site [chemical binding]; other site 1112204009606 active site 1112204009607 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204009608 MarR family; Region: MarR; pfam01047 1112204009609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009611 putative substrate translocation pore; other site 1112204009612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204009613 sequence-specific DNA binding site [nucleotide binding]; other site 1112204009614 salt bridge; other site 1112204009615 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1112204009616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204009617 NAD(P) binding site [chemical binding]; other site 1112204009618 active site 1112204009619 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1112204009620 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1112204009621 Magnesium ion binding site [ion binding]; other site 1112204009622 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1112204009623 nudix motif; other site 1112204009624 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1112204009625 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1112204009626 putative NAD(P) binding site [chemical binding]; other site 1112204009627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1112204009628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1112204009629 active site 1112204009630 catalytic tetrad [active] 1112204009631 aminotransferase; Validated; Region: PRK07337 1112204009632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204009633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204009634 homodimer interface [polypeptide binding]; other site 1112204009635 catalytic residue [active] 1112204009636 Beta-lactamase; Region: Beta-lactamase; pfam00144 1112204009637 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1112204009638 RibD C-terminal domain; Region: RibD_C; cl17279 1112204009639 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1112204009640 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1112204009641 dimerization interface [polypeptide binding]; other site 1112204009642 putative path to active site cavity [active] 1112204009643 diiron center [ion binding]; other site 1112204009644 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1112204009645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204009646 catalytic loop [active] 1112204009647 iron binding site [ion binding]; other site 1112204009648 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 1112204009649 FAD binding pocket [chemical binding]; other site 1112204009650 FAD binding motif [chemical binding]; other site 1112204009651 phosphate binding motif [ion binding]; other site 1112204009652 beta-alpha-beta structure motif; other site 1112204009653 NAD binding pocket [chemical binding]; other site 1112204009654 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1112204009655 dimerization interface [polypeptide binding]; other site 1112204009656 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1112204009657 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1112204009658 active site 1112204009659 Domain of unknown function DUF59; Region: DUF59; pfam01883 1112204009660 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1112204009661 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1112204009662 NAD binding site [chemical binding]; other site 1112204009663 substrate binding site [chemical binding]; other site 1112204009664 catalytic Zn binding site [ion binding]; other site 1112204009665 structural Zn binding site [ion binding]; other site 1112204009666 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 1112204009667 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1112204009668 ring oligomerisation interface [polypeptide binding]; other site 1112204009669 ATP/Mg binding site [chemical binding]; other site 1112204009670 stacking interactions; other site 1112204009671 hinge regions; other site 1112204009672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204009673 Walker A/P-loop; other site 1112204009674 ATP binding site [chemical binding]; other site 1112204009675 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1112204009676 DNA-binding interface [nucleotide binding]; DNA binding site 1112204009677 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1112204009678 intersubunit interface [polypeptide binding]; other site 1112204009679 active site 1112204009680 Zn2+ binding site [ion binding]; other site 1112204009681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204009682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204009683 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1112204009684 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1112204009685 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204009686 active site 1112204009687 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1112204009688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204009689 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1112204009690 NAD(P) binding site [chemical binding]; other site 1112204009691 active site 1112204009692 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1112204009693 active site 1112204009694 catalytic triad [active] 1112204009695 oxyanion hole [active] 1112204009696 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204009697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204009698 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1112204009699 dinuclear metal binding motif [ion binding]; other site 1112204009700 short chain dehydrogenase; Provisional; Region: PRK05650 1112204009701 classical (c) SDRs; Region: SDR_c; cd05233 1112204009702 NAD(P) binding site [chemical binding]; other site 1112204009703 active site 1112204009704 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1112204009705 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204009706 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1112204009707 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1112204009708 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1112204009709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204009710 active site 1112204009711 motif I; other site 1112204009712 motif II; other site 1112204009713 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1112204009714 nudix motif; other site 1112204009715 xanthine permease; Region: pbuX; TIGR03173 1112204009716 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204009717 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1112204009718 active site 1112204009719 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1112204009720 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1112204009721 hinge; other site 1112204009722 active site 1112204009723 Predicted GTPases [General function prediction only]; Region: COG1162 1112204009724 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1112204009725 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1112204009726 GTP/Mg2+ binding site [chemical binding]; other site 1112204009727 G4 box; other site 1112204009728 G5 box; other site 1112204009729 G1 box; other site 1112204009730 Switch I region; other site 1112204009731 G2 box; other site 1112204009732 G3 box; other site 1112204009733 Switch II region; other site 1112204009734 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204009735 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204009736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1112204009737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204009738 DNA-binding site [nucleotide binding]; DNA binding site 1112204009739 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1112204009740 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1112204009741 DNA binding site [nucleotide binding] 1112204009742 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1112204009743 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1112204009744 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1112204009745 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1112204009746 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1112204009747 Metal-binding active site; metal-binding site 1112204009748 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1112204009749 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1112204009750 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1112204009751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009752 putative substrate translocation pore; other site 1112204009753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009754 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1112204009755 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1112204009756 DNA binding site [nucleotide binding] 1112204009757 domain linker motif; other site 1112204009758 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1112204009759 dimerization interface [polypeptide binding]; other site 1112204009760 ligand binding site [chemical binding]; other site 1112204009761 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1112204009762 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1112204009763 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1112204009764 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204009765 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204009766 active site 1112204009767 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1112204009768 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1112204009769 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1112204009770 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1112204009771 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1112204009772 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1112204009773 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1112204009774 dimerization interface [polypeptide binding]; other site 1112204009775 ligand binding site [chemical binding]; other site 1112204009776 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1112204009777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009778 putative transporter; Provisional; Region: PRK10504 1112204009779 putative substrate translocation pore; other site 1112204009780 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1112204009781 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1112204009782 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1112204009783 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1112204009784 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1112204009785 substrate binding site [chemical binding]; other site 1112204009786 ATP binding site [chemical binding]; other site 1112204009787 KduI/IolB family; Region: KduI; pfam04962 1112204009788 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1112204009789 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1112204009790 PYR/PP interface [polypeptide binding]; other site 1112204009791 dimer interface [polypeptide binding]; other site 1112204009792 TPP binding site [chemical binding]; other site 1112204009793 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1112204009794 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1112204009795 TPP-binding site; other site 1112204009796 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1112204009797 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1112204009798 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1112204009799 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1112204009800 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1112204009801 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1112204009802 Metal-binding active site; metal-binding site 1112204009803 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1112204009804 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1112204009805 tetrameric interface [polypeptide binding]; other site 1112204009806 NAD binding site [chemical binding]; other site 1112204009807 catalytic residues [active] 1112204009808 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1112204009809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1112204009810 DNA binding site [nucleotide binding] 1112204009811 domain linker motif; other site 1112204009812 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1112204009813 dimerization interface [polypeptide binding]; other site 1112204009814 ligand binding site [chemical binding]; other site 1112204009815 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1112204009816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009817 putative substrate translocation pore; other site 1112204009818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009819 putative oxidoreductase; Provisional; Region: PRK11579 1112204009820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1112204009821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1112204009822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204009823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204009824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204009825 dimerization interface [polypeptide binding]; other site 1112204009826 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1112204009827 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1112204009828 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1112204009829 putative di-iron ligands [ion binding]; other site 1112204009830 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1112204009831 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1112204009832 putative di-iron ligands [ion binding]; other site 1112204009833 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1112204009834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1112204009835 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1112204009836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1112204009837 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1112204009838 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204009839 FAD binding pocket [chemical binding]; other site 1112204009840 FAD binding motif [chemical binding]; other site 1112204009841 phosphate binding motif [ion binding]; other site 1112204009842 beta-alpha-beta structure motif; other site 1112204009843 NAD binding pocket [chemical binding]; other site 1112204009844 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1112204009845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204009846 catalytic loop [active] 1112204009847 iron binding site [ion binding]; other site 1112204009848 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1112204009849 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1112204009850 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1112204009851 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1112204009852 putative NAD(P) binding site [chemical binding]; other site 1112204009853 catalytic Zn binding site [ion binding]; other site 1112204009854 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1112204009855 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1112204009856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1112204009857 nucleotide binding region [chemical binding]; other site 1112204009858 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1112204009859 30S subunit binding site; other site 1112204009860 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1112204009861 lipoprotein LpqB; Provisional; Region: PRK13616 1112204009862 Sporulation and spore germination; Region: Germane; pfam10646 1112204009863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1112204009864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204009865 dimerization interface [polypeptide binding]; other site 1112204009866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204009867 dimer interface [polypeptide binding]; other site 1112204009868 phosphorylation site [posttranslational modification] 1112204009869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204009870 ATP binding site [chemical binding]; other site 1112204009871 Mg2+ binding site [ion binding]; other site 1112204009872 G-X-G motif; other site 1112204009873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204009874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204009875 active site 1112204009876 phosphorylation site [posttranslational modification] 1112204009877 intermolecular recognition site; other site 1112204009878 dimerization interface [polypeptide binding]; other site 1112204009879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204009880 DNA binding site [nucleotide binding] 1112204009881 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1112204009882 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 1112204009883 TMP-binding site; other site 1112204009884 ATP-binding site [chemical binding]; other site 1112204009885 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1112204009886 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1112204009887 homotetramer interface [polypeptide binding]; other site 1112204009888 ligand binding site [chemical binding]; other site 1112204009889 catalytic site [active] 1112204009890 NAD binding site [chemical binding]; other site 1112204009891 amino acid transporter; Region: 2A0306; TIGR00909 1112204009892 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1112204009893 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1112204009894 Cation efflux family; Region: Cation_efflux; pfam01545 1112204009895 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1112204009896 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1112204009897 EspG family; Region: ESX-1_EspG; pfam14011 1112204009898 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1112204009899 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1112204009900 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1112204009901 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204009902 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204009903 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204009904 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1112204009905 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1112204009906 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204009907 active site 1112204009908 metal binding site [ion binding]; metal-binding site 1112204009909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204009910 metabolite-proton symporter; Region: 2A0106; TIGR00883 1112204009911 putative substrate translocation pore; other site 1112204009912 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1112204009913 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1112204009914 NAD(P) binding site [chemical binding]; other site 1112204009915 shikimate binding site; other site 1112204009916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204009917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204009918 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1112204009919 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1112204009920 dimerization interface 3.5A [polypeptide binding]; other site 1112204009921 active site 1112204009922 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1112204009923 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1112204009924 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1112204009925 alphaNTD homodimer interface [polypeptide binding]; other site 1112204009926 alphaNTD - beta interaction site [polypeptide binding]; other site 1112204009927 alphaNTD - beta' interaction site [polypeptide binding]; other site 1112204009928 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1112204009929 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1112204009930 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1112204009931 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1112204009932 RNA binding surface [nucleotide binding]; other site 1112204009933 30S ribosomal protein S11; Validated; Region: PRK05309 1112204009934 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1112204009935 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1112204009936 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1112204009937 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1112204009938 rRNA binding site [nucleotide binding]; other site 1112204009939 predicted 30S ribosome binding site; other site 1112204009940 Predicted membrane protein [Function unknown]; Region: COG1950 1112204009941 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1112204009942 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1112204009943 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 1112204009944 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1112204009945 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1112204009946 putative active site [active] 1112204009947 dimerization interface [polypeptide binding]; other site 1112204009948 putative tRNAtyr binding site [nucleotide binding]; other site 1112204009949 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1112204009950 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1112204009951 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1112204009952 Walker A/P-loop; other site 1112204009953 ATP binding site [chemical binding]; other site 1112204009954 Q-loop/lid; other site 1112204009955 ABC transporter signature motif; other site 1112204009956 Walker B; other site 1112204009957 D-loop; other site 1112204009958 H-loop/switch region; other site 1112204009959 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1112204009960 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1112204009961 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1112204009962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204009963 dimer interface [polypeptide binding]; other site 1112204009964 conserved gate region; other site 1112204009965 putative PBP binding loops; other site 1112204009966 ABC-ATPase subunit interface; other site 1112204009967 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1112204009968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204009969 dimer interface [polypeptide binding]; other site 1112204009970 conserved gate region; other site 1112204009971 putative PBP binding loops; other site 1112204009972 ABC-ATPase subunit interface; other site 1112204009973 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1112204009974 active site 1112204009975 adenylate kinase; Reviewed; Region: adk; PRK00279 1112204009976 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1112204009977 AMP-binding site [chemical binding]; other site 1112204009978 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1112204009979 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1112204009980 SecY translocase; Region: SecY; pfam00344 1112204009981 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1112204009982 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1112204009983 23S rRNA binding site [nucleotide binding]; other site 1112204009984 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1112204009985 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1112204009986 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1112204009987 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1112204009988 5S rRNA interface [nucleotide binding]; other site 1112204009989 L27 interface [polypeptide binding]; other site 1112204009990 23S rRNA interface [nucleotide binding]; other site 1112204009991 L5 interface [polypeptide binding]; other site 1112204009992 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1112204009993 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1112204009994 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1112204009995 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1112204009996 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1112204009997 Cupin domain; Region: Cupin_2; cl17218 1112204009998 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1112204009999 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1112204010000 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1112204010001 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1112204010002 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1112204010003 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 1112204010004 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 1112204010005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1112204010006 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1112204010007 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1112204010008 AAA domain; Region: AAA_14; pfam13173 1112204010009 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 1112204010010 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1112204010011 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1112204010012 Magnesium ion binding site [ion binding]; other site 1112204010013 Z1 domain; Region: Z1; pfam10593 1112204010014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204010015 ATP binding site [chemical binding]; other site 1112204010016 Mg2+ binding site [ion binding]; other site 1112204010017 G-X-G motif; other site 1112204010018 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1112204010019 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1112204010020 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1112204010021 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1112204010022 Lipase (class 2); Region: Lipase_2; pfam01674 1112204010023 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204010024 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1112204010025 Fumarase [Energy production and conversion]; Region: FumC; COG0114 1112204010026 Aspartase; Region: Aspartase; cd01357 1112204010027 active sites [active] 1112204010028 tetramer interface [polypeptide binding]; other site 1112204010029 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1112204010030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204010031 DNA-binding site [nucleotide binding]; DNA binding site 1112204010032 FCD domain; Region: FCD; pfam07729 1112204010033 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1112204010034 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204010035 active site 1 [active] 1112204010036 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1112204010037 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1112204010038 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1112204010039 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1112204010040 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1112204010041 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1112204010042 RNA binding site [nucleotide binding]; other site 1112204010043 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1112204010044 Condensation domain; Region: Condensation; pfam00668 1112204010045 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010046 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204010047 acyl-activating enzyme (AAE) consensus motif; other site 1112204010048 AMP binding site [chemical binding]; other site 1112204010049 Condensation domain; Region: Condensation; pfam00668 1112204010050 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204010051 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010052 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010053 acyl-activating enzyme (AAE) consensus motif; other site 1112204010054 AMP binding site [chemical binding]; other site 1112204010055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010056 Condensation domain; Region: Condensation; pfam00668 1112204010057 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010058 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010059 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204010060 acyl-activating enzyme (AAE) consensus motif; other site 1112204010061 AMP binding site [chemical binding]; other site 1112204010062 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010063 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1112204010064 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010065 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010066 acyl-activating enzyme (AAE) consensus motif; other site 1112204010067 AMP binding site [chemical binding]; other site 1112204010068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010069 MbtH-like protein; Region: MbtH; cl01279 1112204010070 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1112204010071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204010072 Walker A/P-loop; other site 1112204010073 ATP binding site [chemical binding]; other site 1112204010074 Q-loop/lid; other site 1112204010075 ABC transporter signature motif; other site 1112204010076 Walker B; other site 1112204010077 D-loop; other site 1112204010078 H-loop/switch region; other site 1112204010079 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1112204010080 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204010081 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1112204010082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204010083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1112204010084 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1112204010085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204010086 DNA binding residues [nucleotide binding] 1112204010087 dimerization interface [polypeptide binding]; other site 1112204010088 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1112204010089 Pirin-related protein [General function prediction only]; Region: COG1741 1112204010090 Pirin; Region: Pirin; pfam02678 1112204010091 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1112204010092 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1112204010093 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1112204010094 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1112204010095 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1112204010096 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204010097 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204010098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1112204010099 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010100 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204010101 acyl-activating enzyme (AAE) consensus motif; other site 1112204010102 AMP binding site [chemical binding]; other site 1112204010103 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010104 Condensation domain; Region: Condensation; pfam00668 1112204010105 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010106 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010107 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204010108 acyl-activating enzyme (AAE) consensus motif; other site 1112204010109 AMP binding site [chemical binding]; other site 1112204010110 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010111 Condensation domain; Region: Condensation; pfam00668 1112204010112 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1112204010113 Condensation domain; Region: Condensation; pfam00668 1112204010114 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204010115 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010116 acyl-activating enzyme (AAE) consensus motif; other site 1112204010117 AMP binding site [chemical binding]; other site 1112204010118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010119 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1112204010120 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010121 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010122 acyl-activating enzyme (AAE) consensus motif; other site 1112204010123 AMP binding site [chemical binding]; other site 1112204010124 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010125 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010126 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204010127 acyl-activating enzyme (AAE) consensus motif; other site 1112204010128 AMP binding site [chemical binding]; other site 1112204010129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010130 peptide synthase; Provisional; Region: PRK12467 1112204010131 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010132 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010133 acyl-activating enzyme (AAE) consensus motif; other site 1112204010134 AMP binding site [chemical binding]; other site 1112204010135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010136 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010137 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010138 acyl-activating enzyme (AAE) consensus motif; other site 1112204010139 AMP binding site [chemical binding]; other site 1112204010140 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010141 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1112204010142 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010143 acyl-activating enzyme (AAE) consensus motif; other site 1112204010144 AMP binding site [chemical binding]; other site 1112204010145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010146 peptide synthase; Provisional; Region: PRK12467 1112204010147 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010148 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010149 acyl-activating enzyme (AAE) consensus motif; other site 1112204010150 AMP binding site [chemical binding]; other site 1112204010151 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010152 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010153 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010154 acyl-activating enzyme (AAE) consensus motif; other site 1112204010155 AMP binding site [chemical binding]; other site 1112204010156 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010157 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1112204010158 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010159 acyl-activating enzyme (AAE) consensus motif; other site 1112204010160 AMP binding site [chemical binding]; other site 1112204010161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010162 Condensation domain; Region: Condensation; pfam00668 1112204010163 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204010164 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010165 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010166 acyl-activating enzyme (AAE) consensus motif; other site 1112204010167 AMP binding site [chemical binding]; other site 1112204010168 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010169 peptide synthase; Provisional; Region: PRK12467 1112204010170 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010171 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010172 acyl-activating enzyme (AAE) consensus motif; other site 1112204010173 AMP binding site [chemical binding]; other site 1112204010174 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010175 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010176 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010177 acyl-activating enzyme (AAE) consensus motif; other site 1112204010178 AMP binding site [chemical binding]; other site 1112204010179 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010180 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1112204010181 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010182 acyl-activating enzyme (AAE) consensus motif; other site 1112204010183 AMP binding site [chemical binding]; other site 1112204010184 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010185 Condensation domain; Region: Condensation; pfam00668 1112204010186 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204010187 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010188 Condensation domain; Region: Condensation; pfam00668 1112204010189 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010190 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204010191 acyl-activating enzyme (AAE) consensus motif; other site 1112204010192 AMP binding site [chemical binding]; other site 1112204010193 Condensation domain; Region: Condensation; pfam00668 1112204010194 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204010195 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010196 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204010197 acyl-activating enzyme (AAE) consensus motif; other site 1112204010198 AMP binding site [chemical binding]; other site 1112204010199 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010200 Condensation domain; Region: Condensation; pfam00668 1112204010201 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1112204010202 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1112204010203 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204010204 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1112204010205 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1112204010206 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204010207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204010208 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1112204010209 Walker A/P-loop; other site 1112204010210 ATP binding site [chemical binding]; other site 1112204010211 Q-loop/lid; other site 1112204010212 ABC transporter signature motif; other site 1112204010213 Walker B; other site 1112204010214 D-loop; other site 1112204010215 H-loop/switch region; other site 1112204010216 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1112204010217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1112204010218 active site 1112204010219 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1112204010220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204010221 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204010222 active site 1112204010223 ATP binding site [chemical binding]; other site 1112204010224 substrate binding site [chemical binding]; other site 1112204010225 activation loop (A-loop); other site 1112204010226 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1112204010227 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1112204010228 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1112204010229 Ligand Binding Site [chemical binding]; other site 1112204010230 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1112204010231 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1112204010232 23S rRNA interface [nucleotide binding]; other site 1112204010233 putative translocon interaction site; other site 1112204010234 signal recognition particle (SRP54) interaction site; other site 1112204010235 L23 interface [polypeptide binding]; other site 1112204010236 trigger factor interaction site; other site 1112204010237 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1112204010238 23S rRNA interface [nucleotide binding]; other site 1112204010239 5S rRNA interface [nucleotide binding]; other site 1112204010240 putative antibiotic binding site [chemical binding]; other site 1112204010241 L25 interface [polypeptide binding]; other site 1112204010242 L27 interface [polypeptide binding]; other site 1112204010243 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1112204010244 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1112204010245 G-X-X-G motif; other site 1112204010246 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1112204010247 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1112204010248 putative translocon binding site; other site 1112204010249 protein-rRNA interface [nucleotide binding]; other site 1112204010250 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1112204010251 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1112204010252 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1112204010253 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1112204010254 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1112204010255 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1112204010256 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1112204010257 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1112204010258 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1112204010259 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1112204010260 putative Iron-sulfur protein interface [polypeptide binding]; other site 1112204010261 proximal heme binding site [chemical binding]; other site 1112204010262 distal heme binding site [chemical binding]; other site 1112204010263 putative dimer interface [polypeptide binding]; other site 1112204010264 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1112204010265 L-aspartate oxidase; Provisional; Region: PRK06175 1112204010266 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1112204010267 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1112204010268 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204010269 catalytic loop [active] 1112204010270 iron binding site [ion binding]; other site 1112204010271 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1112204010272 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1112204010273 transmembrane helices; other site 1112204010274 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1112204010275 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1112204010276 active site 1112204010277 dimer interface [polypeptide binding]; other site 1112204010278 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1112204010279 Ligand Binding Site [chemical binding]; other site 1112204010280 Molecular Tunnel; other site 1112204010281 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1112204010282 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204010283 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204010284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204010285 DNA-binding site [nucleotide binding]; DNA binding site 1112204010286 FCD domain; Region: FCD; pfam07729 1112204010287 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1112204010288 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1112204010289 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1112204010290 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1112204010291 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 1112204010292 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1112204010293 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1112204010294 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1112204010295 Na binding site [ion binding]; other site 1112204010296 putative substrate binding site [chemical binding]; other site 1112204010297 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1112204010298 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1112204010299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204010300 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204010301 DNA binding residues [nucleotide binding] 1112204010302 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1112204010303 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1112204010304 metal-binding site [ion binding] 1112204010305 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1112204010306 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1112204010307 Putative zinc-finger; Region: zf-HC2; pfam13490 1112204010308 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1112204010309 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1112204010310 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1112204010311 catalytic residues [active] 1112204010312 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1112204010313 putative active site [active] 1112204010314 redox center [active] 1112204010315 CopC domain; Region: CopC; pfam04234 1112204010316 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1112204010317 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1112204010318 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1112204010319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1112204010320 active site 1112204010321 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1112204010322 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204010323 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204010324 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1112204010325 classical (c) SDRs; Region: SDR_c; cd05233 1112204010326 NAD(P) binding site [chemical binding]; other site 1112204010327 active site 1112204010328 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1112204010329 phosphate binding site [ion binding]; other site 1112204010330 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1112204010331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204010332 FeS/SAM binding site; other site 1112204010333 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1112204010334 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1112204010335 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1112204010336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204010337 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1112204010338 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1112204010339 FAD binding pocket [chemical binding]; other site 1112204010340 FAD binding motif [chemical binding]; other site 1112204010341 phosphate binding motif [ion binding]; other site 1112204010342 beta-alpha-beta structure motif; other site 1112204010343 NAD(p) ribose binding residues [chemical binding]; other site 1112204010344 NAD binding pocket [chemical binding]; other site 1112204010345 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1112204010346 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204010347 catalytic loop [active] 1112204010348 iron binding site [ion binding]; other site 1112204010349 Predicted membrane protein [Function unknown]; Region: COG4270 1112204010350 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1112204010351 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1112204010352 Cl- selectivity filter; other site 1112204010353 Cl- binding residues [ion binding]; other site 1112204010354 pore gating glutamate residue; other site 1112204010355 dimer interface [polypeptide binding]; other site 1112204010356 H+/Cl- coupling transport residue; other site 1112204010357 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1112204010358 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1112204010359 active site 1112204010360 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1112204010361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204010362 short chain dehydrogenase; Provisional; Region: PRK07825 1112204010363 classical (c) SDRs; Region: SDR_c; cd05233 1112204010364 NAD(P) binding site [chemical binding]; other site 1112204010365 active site 1112204010366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204010367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204010368 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204010369 Cytochrome P450; Region: p450; cl12078 1112204010370 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1112204010371 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 1112204010372 active site 1112204010373 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1112204010374 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204010375 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204010376 S-formylglutathione hydrolase; Region: PLN02442 1112204010377 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1112204010378 structural tetrad; other site 1112204010379 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1112204010380 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1112204010381 structural tetrad; other site 1112204010382 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1112204010383 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204010384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204010385 DNA binding residues [nucleotide binding] 1112204010386 dimerization interface [polypeptide binding]; other site 1112204010387 Predicted esterase [General function prediction only]; Region: COG0627 1112204010388 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 1112204010389 hypothetical protein; Provisional; Region: PRK05409 1112204010390 elongation factor Tu; Reviewed; Region: PRK00049 1112204010391 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1112204010392 G1 box; other site 1112204010393 GEF interaction site [polypeptide binding]; other site 1112204010394 GTP/Mg2+ binding site [chemical binding]; other site 1112204010395 Switch I region; other site 1112204010396 G2 box; other site 1112204010397 G3 box; other site 1112204010398 Switch II region; other site 1112204010399 G4 box; other site 1112204010400 G5 box; other site 1112204010401 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1112204010402 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1112204010403 Antibiotic Binding Site [chemical binding]; other site 1112204010404 elongation factor G; Reviewed; Region: PRK00007 1112204010405 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1112204010406 G1 box; other site 1112204010407 putative GEF interaction site [polypeptide binding]; other site 1112204010408 GTP/Mg2+ binding site [chemical binding]; other site 1112204010409 Switch I region; other site 1112204010410 G2 box; other site 1112204010411 G3 box; other site 1112204010412 Switch II region; other site 1112204010413 G4 box; other site 1112204010414 G5 box; other site 1112204010415 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1112204010416 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1112204010417 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1112204010418 30S ribosomal protein S7; Validated; Region: PRK05302 1112204010419 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1112204010420 S17 interaction site [polypeptide binding]; other site 1112204010421 S8 interaction site; other site 1112204010422 16S rRNA interaction site [nucleotide binding]; other site 1112204010423 streptomycin interaction site [chemical binding]; other site 1112204010424 23S rRNA interaction site [nucleotide binding]; other site 1112204010425 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1112204010426 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1112204010427 putative catalytic site [active] 1112204010428 putative phosphate binding site [ion binding]; other site 1112204010429 active site 1112204010430 metal binding site A [ion binding]; metal-binding site 1112204010431 DNA binding site [nucleotide binding] 1112204010432 putative AP binding site [nucleotide binding]; other site 1112204010433 putative metal binding site B [ion binding]; other site 1112204010434 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204010435 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204010436 active site 1112204010437 ATP binding site [chemical binding]; other site 1112204010438 substrate binding site [chemical binding]; other site 1112204010439 activation loop (A-loop); other site 1112204010440 AAA domain; Region: AAA_22; pfam13401 1112204010441 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1112204010442 HPP family; Region: HPP; pfam04982 1112204010443 FOG: CBS domain [General function prediction only]; Region: COG0517 1112204010444 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1112204010445 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1112204010446 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204010447 NAD(P) binding site [chemical binding]; other site 1112204010448 catalytic residues [active] 1112204010449 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1112204010450 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1112204010451 NAD binding site [chemical binding]; other site 1112204010452 catalytic Zn binding site [ion binding]; other site 1112204010453 substrate binding site [chemical binding]; other site 1112204010454 structural Zn binding site [ion binding]; other site 1112204010455 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1112204010456 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204010457 enoyl-CoA hydratase; Provisional; Region: PRK07827 1112204010458 substrate binding site [chemical binding]; other site 1112204010459 oxyanion hole (OAH) forming residues; other site 1112204010460 trimer interface [polypeptide binding]; other site 1112204010461 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204010462 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1112204010463 active site 1112204010464 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1112204010465 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204010466 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204010467 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1112204010468 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1112204010469 carboxyltransferase (CT) interaction site; other site 1112204010470 biotinylation site [posttranslational modification]; other site 1112204010471 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1112204010472 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1112204010473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204010474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204010475 active site 1112204010476 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1112204010477 TIGR03084 family protein; Region: TIGR03084 1112204010478 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1112204010479 Wyosine base formation; Region: Wyosine_form; pfam08608 1112204010480 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204010481 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1112204010482 CoenzymeA binding site [chemical binding]; other site 1112204010483 subunit interaction site [polypeptide binding]; other site 1112204010484 PHB binding site; other site 1112204010485 acyl-CoA synthetase; Provisional; Region: PRK13388 1112204010486 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204010487 acyl-activating enzyme (AAE) consensus motif; other site 1112204010488 AMP binding site [chemical binding]; other site 1112204010489 active site 1112204010490 CoA binding site [chemical binding]; other site 1112204010491 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1112204010492 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204010493 Ecdysteroid kinase; Region: EcKinase; cl17738 1112204010494 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204010495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204010496 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1112204010497 NAD(P) binding site [chemical binding]; other site 1112204010498 active site 1112204010499 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1112204010500 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204010501 classical (c) SDRs; Region: SDR_c; cd05233 1112204010502 NAD(P) binding site [chemical binding]; other site 1112204010503 active site 1112204010504 SnoaL-like domain; Region: SnoaL_3; pfam13474 1112204010505 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1112204010506 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1112204010507 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204010508 Cytochrome P450; Region: p450; cl12078 1112204010509 short chain dehydrogenase; Provisional; Region: PRK07775 1112204010510 classical (c) SDRs; Region: SDR_c; cd05233 1112204010511 NAD(P) binding site [chemical binding]; other site 1112204010512 active site 1112204010513 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204010514 Cytochrome P450; Region: p450; cl12078 1112204010515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204010516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204010517 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1112204010518 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1112204010519 NAD binding site [chemical binding]; other site 1112204010520 catalytic residues [active] 1112204010521 short chain dehydrogenase; Provisional; Region: PRK07774 1112204010522 classical (c) SDRs; Region: SDR_c; cd05233 1112204010523 NAD(P) binding site [chemical binding]; other site 1112204010524 active site 1112204010525 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1112204010526 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1112204010527 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1112204010528 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204010529 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204010530 active site 1112204010531 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204010532 CoenzymeA binding site [chemical binding]; other site 1112204010533 subunit interaction site [polypeptide binding]; other site 1112204010534 PHB binding site; other site 1112204010535 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1112204010536 active site 1112204010537 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1112204010538 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1112204010539 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1112204010540 NAD(P) binding site [chemical binding]; other site 1112204010541 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1112204010542 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204010543 classical (c) SDRs; Region: SDR_c; cd05233 1112204010544 NAD(P) binding site [chemical binding]; other site 1112204010545 active site 1112204010546 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1112204010547 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204010548 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 1112204010549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204010550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204010551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204010552 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1112204010553 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204010554 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1112204010555 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1112204010556 structural tetrad; other site 1112204010557 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1112204010558 structural tetrad; other site 1112204010559 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1112204010560 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1112204010561 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1112204010562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204010563 S-adenosylmethionine binding site [chemical binding]; other site 1112204010564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204010565 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1112204010566 Ferredoxin [Energy production and conversion]; Region: COG1146 1112204010567 4Fe-4S binding domain; Region: Fer4; pfam00037 1112204010568 ferredoxin-NADP+ reductase; Region: PLN02852 1112204010569 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204010570 active site 2 [active] 1112204010571 active site 1 [active] 1112204010572 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204010573 active site 2 [active] 1112204010574 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1112204010575 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1112204010576 RNA binding surface [nucleotide binding]; other site 1112204010577 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1112204010578 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1112204010579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204010580 WHG domain; Region: WHG; pfam13305 1112204010581 allophanate hydrolase; Provisional; Region: PRK08186 1112204010582 Amidase; Region: Amidase; cl11426 1112204010583 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1112204010584 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1112204010585 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1112204010586 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1112204010587 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1112204010588 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1112204010589 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1112204010590 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1112204010591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204010592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204010593 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1112204010594 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1112204010595 metal binding site [ion binding]; metal-binding site 1112204010596 active site 1112204010597 I-site; other site 1112204010598 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204010599 MarR family; Region: MarR; pfam01047 1112204010600 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1112204010601 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1112204010602 putative active site [active] 1112204010603 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1112204010604 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1112204010605 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204010606 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1112204010607 substrate binding pocket [chemical binding]; other site 1112204010608 FAD binding site [chemical binding]; other site 1112204010609 catalytic base [active] 1112204010610 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1112204010611 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1112204010612 tetrameric interface [polypeptide binding]; other site 1112204010613 NAD binding site [chemical binding]; other site 1112204010614 catalytic residues [active] 1112204010615 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 1112204010616 EamA-like transporter family; Region: EamA; pfam00892 1112204010617 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1112204010618 catalytic core [active] 1112204010619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204010620 dimerization interface [polypeptide binding]; other site 1112204010621 putative DNA binding site [nucleotide binding]; other site 1112204010622 putative Zn2+ binding site [ion binding]; other site 1112204010623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204010624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204010625 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1112204010626 Lipase (class 2); Region: Lipase_2; pfam01674 1112204010627 DNA polymerase IV; Validated; Region: PRK03352 1112204010628 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1112204010629 active site 1112204010630 DNA binding site [nucleotide binding] 1112204010631 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1112204010632 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1112204010633 putative active site [active] 1112204010634 catalytic triad [active] 1112204010635 putative dimer interface [polypeptide binding]; other site 1112204010636 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1112204010637 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1112204010638 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1112204010639 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1112204010640 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1112204010641 GAF domain; Region: GAF_3; pfam13492 1112204010642 PAS domain S-box; Region: sensory_box; TIGR00229 1112204010643 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1112204010644 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1112204010645 metal binding site [ion binding]; metal-binding site 1112204010646 active site 1112204010647 I-site; other site 1112204010648 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1112204010649 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204010650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204010651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204010652 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1112204010653 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1112204010654 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1112204010655 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1112204010656 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1112204010657 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1112204010658 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1112204010659 G-loop; other site 1112204010660 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1112204010661 DNA binding site [nucleotide binding] 1112204010662 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1112204010663 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1112204010664 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1112204010665 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1112204010666 RPB12 interaction site [polypeptide binding]; other site 1112204010667 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1112204010668 RPB10 interaction site [polypeptide binding]; other site 1112204010669 RPB1 interaction site [polypeptide binding]; other site 1112204010670 RPB11 interaction site [polypeptide binding]; other site 1112204010671 RPB3 interaction site [polypeptide binding]; other site 1112204010672 RPB12 interaction site [polypeptide binding]; other site 1112204010673 SnoaL-like domain; Region: SnoaL_4; cl17707 1112204010674 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204010675 mce related protein; Region: MCE; pfam02470 1112204010676 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204010677 mce related protein; Region: MCE; pfam02470 1112204010678 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204010679 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204010680 mce related protein; Region: MCE; pfam02470 1112204010681 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204010682 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204010683 mce related protein; Region: MCE; pfam02470 1112204010684 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204010685 mce related protein; Region: MCE; pfam02470 1112204010686 mce related protein; Region: MCE; pfam02470 1112204010687 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204010688 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1112204010689 Permease; Region: Permease; pfam02405 1112204010690 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1112204010691 Permease; Region: Permease; pfam02405 1112204010692 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1112204010693 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1112204010694 Walker A/P-loop; other site 1112204010695 ATP binding site [chemical binding]; other site 1112204010696 Q-loop/lid; other site 1112204010697 ABC transporter signature motif; other site 1112204010698 Walker B; other site 1112204010699 D-loop; other site 1112204010700 H-loop/switch region; other site 1112204010701 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1112204010702 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1112204010703 core dimer interface [polypeptide binding]; other site 1112204010704 peripheral dimer interface [polypeptide binding]; other site 1112204010705 L10 interface [polypeptide binding]; other site 1112204010706 L11 interface [polypeptide binding]; other site 1112204010707 putative EF-Tu interaction site [polypeptide binding]; other site 1112204010708 putative EF-G interaction site [polypeptide binding]; other site 1112204010709 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1112204010710 23S rRNA interface [nucleotide binding]; other site 1112204010711 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1112204010712 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1112204010713 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204010714 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1112204010715 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204010716 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1112204010717 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1112204010718 TAP-like protein; Region: Abhydrolase_4; pfam08386 1112204010719 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204010720 Cytochrome P450; Region: p450; cl12078 1112204010721 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204010722 CoenzymeA binding site [chemical binding]; other site 1112204010723 subunit interaction site [polypeptide binding]; other site 1112204010724 PHB binding site; other site 1112204010725 acyl-CoA synthetase; Validated; Region: PRK05850 1112204010726 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1112204010727 acyl-activating enzyme (AAE) consensus motif; other site 1112204010728 active site 1112204010729 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1112204010730 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204010731 Cytochrome P450; Region: p450; cl12078 1112204010732 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1112204010733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204010734 S-adenosylmethionine binding site [chemical binding]; other site 1112204010735 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1112204010736 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1112204010737 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1112204010738 Di-iron ligands [ion binding]; other site 1112204010739 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1112204010740 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204010741 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1112204010742 FMN-binding pocket [chemical binding]; other site 1112204010743 flavin binding motif; other site 1112204010744 phosphate binding motif [ion binding]; other site 1112204010745 beta-alpha-beta structure motif; other site 1112204010746 NAD binding pocket [chemical binding]; other site 1112204010747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204010748 catalytic loop [active] 1112204010749 iron binding site [ion binding]; other site 1112204010750 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204010751 active site 2 [active] 1112204010752 active site 1 [active] 1112204010753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204010754 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204010755 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1112204010756 nucleophilic elbow; other site 1112204010757 catalytic triad; other site 1112204010758 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1112204010759 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1112204010760 Walker A/P-loop; other site 1112204010761 ATP binding site [chemical binding]; other site 1112204010762 Q-loop/lid; other site 1112204010763 ABC transporter signature motif; other site 1112204010764 Walker B; other site 1112204010765 D-loop; other site 1112204010766 H-loop/switch region; other site 1112204010767 TOBE domain; Region: TOBE; pfam03459 1112204010768 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1112204010769 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1112204010770 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1112204010771 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1112204010772 active site 1112204010773 metal binding site [ion binding]; metal-binding site 1112204010774 hexamer interface [polypeptide binding]; other site 1112204010775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204010776 dimer interface [polypeptide binding]; other site 1112204010777 conserved gate region; other site 1112204010778 putative PBP binding loops; other site 1112204010779 ABC-ATPase subunit interface; other site 1112204010780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1112204010781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204010782 dimer interface [polypeptide binding]; other site 1112204010783 conserved gate region; other site 1112204010784 putative PBP binding loops; other site 1112204010785 ABC-ATPase subunit interface; other site 1112204010786 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1112204010787 phosphate binding site [ion binding]; other site 1112204010788 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204010789 active site 2 [active] 1112204010790 active site 1 [active] 1112204010791 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1112204010792 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1112204010793 active site 1112204010794 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1112204010795 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1112204010796 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010797 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1112204010798 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1112204010799 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1112204010800 putative NADP binding site [chemical binding]; other site 1112204010801 active site 1112204010802 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1112204010803 active site 1112204010804 catalytic triad [active] 1112204010805 oxyanion hole [active] 1112204010806 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1112204010807 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1112204010808 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1112204010809 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1112204010810 acyl-activating enzyme (AAE) consensus motif; other site 1112204010811 putative AMP binding site [chemical binding]; other site 1112204010812 putative active site [active] 1112204010813 putative CoA binding site [chemical binding]; other site 1112204010814 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1112204010815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204010816 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1112204010817 dimerization interface [polypeptide binding]; other site 1112204010818 substrate binding pocket [chemical binding]; other site 1112204010819 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1112204010820 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1112204010821 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1112204010822 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1112204010823 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1112204010824 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1112204010825 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1112204010826 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1112204010827 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1112204010828 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1112204010829 NAD(P) binding site [chemical binding]; other site 1112204010830 LDH/MDH dimer interface [polypeptide binding]; other site 1112204010831 substrate binding site [chemical binding]; other site 1112204010832 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 1112204010833 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1112204010834 dimer interface [polypeptide binding]; other site 1112204010835 active site 1112204010836 metal binding site [ion binding]; metal-binding site 1112204010837 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1112204010838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204010839 Walker A motif; other site 1112204010840 ATP binding site [chemical binding]; other site 1112204010841 Walker B motif; other site 1112204010842 arginine finger; other site 1112204010843 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1112204010844 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204010845 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204010846 active site 1112204010847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204010848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204010849 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1112204010850 FMN binding site [chemical binding]; other site 1112204010851 dimer interface [polypeptide binding]; other site 1112204010852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204010853 ABC-ATPase subunit interface; other site 1112204010854 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1112204010855 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1112204010856 Walker A/P-loop; other site 1112204010857 ATP binding site [chemical binding]; other site 1112204010858 Q-loop/lid; other site 1112204010859 ABC transporter signature motif; other site 1112204010860 Walker B; other site 1112204010861 D-loop; other site 1112204010862 H-loop/switch region; other site 1112204010863 NIL domain; Region: NIL; cl09633 1112204010864 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1112204010865 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1112204010866 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1112204010867 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1112204010868 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1112204010869 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 1112204010870 nudix motif; other site 1112204010871 RDD family; Region: RDD; pfam06271 1112204010872 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1112204010873 putative hydrophobic ligand binding site [chemical binding]; other site 1112204010874 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204010875 Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms]; Region: UspA; COG0589 1112204010876 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1112204010877 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1112204010878 putative substrate binding site [chemical binding]; other site 1112204010879 putative ATP binding site [chemical binding]; other site 1112204010880 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1112204010881 CoA binding domain; Region: CoA_binding; smart00881 1112204010882 CoA-ligase; Region: Ligase_CoA; pfam00549 1112204010883 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1112204010884 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1112204010885 CoA-ligase; Region: Ligase_CoA; pfam00549 1112204010886 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1112204010887 Peptidase family M23; Region: Peptidase_M23; pfam01551 1112204010888 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1112204010889 Part of AAA domain; Region: AAA_19; pfam13245 1112204010890 Family description; Region: UvrD_C_2; pfam13538 1112204010891 hypothetical protein; Provisional; Region: PRK07857 1112204010892 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1112204010893 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1112204010894 active site 1112204010895 dimer interface [polypeptide binding]; other site 1112204010896 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1112204010897 dimer interface [polypeptide binding]; other site 1112204010898 active site 1112204010899 short chain dehydrogenase; Provisional; Region: PRK08251 1112204010900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204010901 NAD(P) binding site [chemical binding]; other site 1112204010902 active site 1112204010903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1112204010904 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1112204010905 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1112204010906 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1112204010907 putative DNA binding site [nucleotide binding]; other site 1112204010908 catalytic residue [active] 1112204010909 putative H2TH interface [polypeptide binding]; other site 1112204010910 putative catalytic residues [active] 1112204010911 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1112204010912 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1112204010913 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1112204010914 active site 1112204010915 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1112204010916 active site 1112204010917 SAM binding site [chemical binding]; other site 1112204010918 homodimer interface [polypeptide binding]; other site 1112204010919 short chain dehydrogenase; Validated; Region: PRK06182 1112204010920 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1112204010921 NADP binding site [chemical binding]; other site 1112204010922 active site 1112204010923 steroid binding site; other site 1112204010924 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1112204010925 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1112204010926 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1112204010927 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204010928 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204010929 active site 1112204010930 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1112204010931 active site 1112204010932 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1112204010933 active site 1112204010934 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1112204010935 non-prolyl cis peptide bond; other site 1112204010936 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204010937 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1112204010938 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1112204010939 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204010940 Walker A/P-loop; other site 1112204010941 ATP binding site [chemical binding]; other site 1112204010942 Q-loop/lid; other site 1112204010943 ABC transporter signature motif; other site 1112204010944 Walker B; other site 1112204010945 D-loop; other site 1112204010946 H-loop/switch region; other site 1112204010947 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1112204010948 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1112204010949 Walker A/P-loop; other site 1112204010950 ATP binding site [chemical binding]; other site 1112204010951 Q-loop/lid; other site 1112204010952 ABC transporter signature motif; other site 1112204010953 Walker B; other site 1112204010954 D-loop; other site 1112204010955 H-loop/switch region; other site 1112204010956 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1112204010957 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1112204010958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1112204010959 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1112204010960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1112204010961 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1112204010962 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1112204010963 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1112204010964 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204010965 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1112204010966 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1112204010967 intersubunit interface [polypeptide binding]; other site 1112204010968 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1112204010969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204010970 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1112204010971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204010972 NAD(P) binding site [chemical binding]; other site 1112204010973 active site 1112204010974 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1112204010975 hydrophobic ligand binding site; other site 1112204010976 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1112204010977 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1112204010978 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204010979 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1112204010980 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1112204010981 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1112204010982 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1112204010983 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204010984 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204010985 active site 1112204010986 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1112204010987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204010988 DNA-binding site [nucleotide binding]; DNA binding site 1112204010989 UTRA domain; Region: UTRA; pfam07702 1112204010990 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 1112204010991 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1112204010992 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1112204010993 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1112204010994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204010995 Walker A/P-loop; other site 1112204010996 ATP binding site [chemical binding]; other site 1112204010997 Q-loop/lid; other site 1112204010998 ABC transporter signature motif; other site 1112204010999 Walker B; other site 1112204011000 D-loop; other site 1112204011001 H-loop/switch region; other site 1112204011002 TOBE domain; Region: TOBE_2; pfam08402 1112204011003 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1112204011004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204011005 dimer interface [polypeptide binding]; other site 1112204011006 conserved gate region; other site 1112204011007 putative PBP binding loops; other site 1112204011008 ABC-ATPase subunit interface; other site 1112204011009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1112204011010 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1112204011011 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1112204011012 NAD(P) binding site [chemical binding]; other site 1112204011013 catalytic residues [active] 1112204011014 Proline dehydrogenase; Region: Pro_dh; cl03282 1112204011015 MOSC domain; Region: MOSC; pfam03473 1112204011016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204011017 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1112204011018 Walker A motif; other site 1112204011019 ATP binding site [chemical binding]; other site 1112204011020 Walker B motif; other site 1112204011021 arginine finger; other site 1112204011022 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 1112204011023 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1112204011024 active site 1112204011025 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1112204011026 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 1112204011027 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1112204011028 active site 1112204011029 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1112204011030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204011031 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1112204011032 dimerization interface [polypeptide binding]; other site 1112204011033 substrate binding pocket [chemical binding]; other site 1112204011034 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1112204011035 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1112204011036 iron-sulfur cluster [ion binding]; other site 1112204011037 [2Fe-2S] cluster binding site [ion binding]; other site 1112204011038 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1112204011039 putative alpha subunit interface [polypeptide binding]; other site 1112204011040 putative active site [active] 1112204011041 putative substrate binding site [chemical binding]; other site 1112204011042 Fe binding site [ion binding]; other site 1112204011043 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1112204011044 inter-subunit interface; other site 1112204011045 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1112204011046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204011047 catalytic loop [active] 1112204011048 iron binding site [ion binding]; other site 1112204011049 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1112204011050 FAD binding pocket [chemical binding]; other site 1112204011051 FAD binding motif [chemical binding]; other site 1112204011052 phosphate binding motif [ion binding]; other site 1112204011053 beta-alpha-beta structure motif; other site 1112204011054 NAD binding pocket [chemical binding]; other site 1112204011055 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1112204011056 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1112204011057 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1112204011058 putative NAD(P) binding site [chemical binding]; other site 1112204011059 active site 1112204011060 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204011061 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204011062 active site 1112204011063 AAA ATPase domain; Region: AAA_16; pfam13191 1112204011064 Walker A motif; other site 1112204011065 ATP binding site [chemical binding]; other site 1112204011066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204011067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204011068 DNA binding residues [nucleotide binding] 1112204011069 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1112204011070 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1112204011071 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1112204011072 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1112204011073 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204011074 dimer interface [polypeptide binding]; other site 1112204011075 active site 1112204011076 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1112204011077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204011078 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1112204011079 dimerization interface [polypeptide binding]; other site 1112204011080 substrate binding pocket [chemical binding]; other site 1112204011081 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1112204011082 FAD binding pocket [chemical binding]; other site 1112204011083 conserved FAD binding motif [chemical binding]; other site 1112204011084 phosphate binding motif [ion binding]; other site 1112204011085 beta-alpha-beta structure motif; other site 1112204011086 NAD binding pocket [chemical binding]; other site 1112204011087 ApbE family; Region: ApbE; pfam02424 1112204011088 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1112204011089 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1112204011090 metal ion-dependent adhesion site (MIDAS); other site 1112204011091 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1112204011092 hydrophobic ligand binding site; other site 1112204011093 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1112204011094 active site 1112204011095 DNA binding site [nucleotide binding] 1112204011096 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1112204011097 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1112204011098 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1112204011099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204011100 motif I; other site 1112204011101 motif II; other site 1112204011102 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1112204011103 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1112204011104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1112204011105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204011106 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1112204011107 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1112204011108 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1112204011109 catalytic residue [active] 1112204011110 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1112204011111 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204011112 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1112204011113 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1112204011114 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1112204011115 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1112204011116 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1112204011117 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1112204011118 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204011119 substrate binding site [chemical binding]; other site 1112204011120 oxyanion hole (OAH) forming residues; other site 1112204011121 trimer interface [polypeptide binding]; other site 1112204011122 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204011123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204011124 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204011125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204011126 non-specific DNA binding site [nucleotide binding]; other site 1112204011127 salt bridge; other site 1112204011128 sequence-specific DNA binding site [nucleotide binding]; other site 1112204011129 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1112204011130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204011131 Walker A/P-loop; other site 1112204011132 ATP binding site [chemical binding]; other site 1112204011133 Q-loop/lid; other site 1112204011134 ABC transporter signature motif; other site 1112204011135 Walker B; other site 1112204011136 D-loop; other site 1112204011137 H-loop/switch region; other site 1112204011138 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1112204011139 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1112204011140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204011141 putative substrate translocation pore; other site 1112204011142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204011143 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204011144 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1112204011145 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1112204011146 AsnC family; Region: AsnC_trans_reg; pfam01037 1112204011147 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1112204011148 DNA photolyase; Region: DNA_photolyase; pfam00875 1112204011149 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1112204011150 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1112204011151 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1112204011152 dimer interface [polypeptide binding]; other site 1112204011153 active site 1112204011154 citrylCoA binding site [chemical binding]; other site 1112204011155 NADH binding [chemical binding]; other site 1112204011156 cationic pore residues; other site 1112204011157 oxalacetate/citrate binding site [chemical binding]; other site 1112204011158 coenzyme A binding site [chemical binding]; other site 1112204011159 catalytic triad [active] 1112204011160 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1112204011161 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1112204011162 putative substrate binding site [chemical binding]; other site 1112204011163 putative ATP binding site [chemical binding]; other site 1112204011164 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1112204011165 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1112204011166 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1112204011167 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204011168 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204011169 active site 1112204011170 oxidase reductase; Provisional; Region: PTZ00273 1112204011171 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204011172 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204011173 enterobactin exporter EntS; Provisional; Region: PRK10489 1112204011174 Predicted transcriptional regulators [Transcription]; Region: COG1695 1112204011175 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1112204011176 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1112204011177 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1112204011178 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1112204011179 citrate synthase 2; Provisional; Region: PRK12350 1112204011180 Citrate synthase; Region: Citrate_synt; pfam00285 1112204011181 oxalacetate binding site [chemical binding]; other site 1112204011182 citrylCoA binding site [chemical binding]; other site 1112204011183 coenzyme A binding site [chemical binding]; other site 1112204011184 catalytic triad [active] 1112204011185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1112204011186 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1112204011187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1112204011188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1112204011189 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1112204011190 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1112204011191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204011192 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204011193 DNA binding residues [nucleotide binding] 1112204011194 dimerization interface [polypeptide binding]; other site 1112204011195 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1112204011196 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1112204011197 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1112204011198 Walker A/P-loop; other site 1112204011199 ATP binding site [chemical binding]; other site 1112204011200 Q-loop/lid; other site 1112204011201 ABC transporter signature motif; other site 1112204011202 Walker B; other site 1112204011203 D-loop; other site 1112204011204 H-loop/switch region; other site 1112204011205 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1112204011206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204011207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204011208 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204011209 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204011210 catalytic residue [active] 1112204011211 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1112204011212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204011213 S-adenosylmethionine binding site [chemical binding]; other site 1112204011214 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1112204011215 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1112204011216 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1112204011217 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1112204011218 hypothetical protein; Provisional; Region: PRK01346 1112204011219 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1112204011220 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204011221 MarR family; Region: MarR; pfam01047 1112204011222 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1112204011223 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1112204011224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204011225 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204011226 enoyl-CoA hydratase; Provisional; Region: PRK06688 1112204011227 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204011228 substrate binding site [chemical binding]; other site 1112204011229 oxyanion hole (OAH) forming residues; other site 1112204011230 trimer interface [polypeptide binding]; other site 1112204011231 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 1112204011232 classical (c) SDRs; Region: SDR_c; cd05233 1112204011233 NAD(P) binding site [chemical binding]; other site 1112204011234 active site 1112204011235 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1112204011236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204011237 acyl-activating enzyme (AAE) consensus motif; other site 1112204011238 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204011239 AMP binding site [chemical binding]; other site 1112204011240 active site 1112204011241 acyl-activating enzyme (AAE) consensus motif; other site 1112204011242 CoA binding site [chemical binding]; other site 1112204011243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011245 active site 1112204011246 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011247 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011248 active site 1112204011249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204011250 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204011251 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1112204011252 putative active site [active] 1112204011253 putative substrate binding site [chemical binding]; other site 1112204011254 ATP binding site [chemical binding]; other site 1112204011255 hypothetical protein; Provisional; Region: PRK06753 1112204011256 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1112204011257 PQQ-like domain; Region: PQQ_2; pfam13360 1112204011258 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1112204011259 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1112204011260 active site 1112204011261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1112204011262 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1112204011263 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204011264 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204011265 active site 1112204011266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011268 active site 1112204011269 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1112204011270 H+ Antiporter protein; Region: 2A0121; TIGR00900 1112204011271 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1112204011272 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1112204011273 DNA-binding site [nucleotide binding]; DNA binding site 1112204011274 RNA-binding motif; other site 1112204011275 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204011276 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1112204011277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204011278 FeS/SAM binding site; other site 1112204011279 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1112204011280 Ubiquitin-like proteins; Region: UBQ; cl00155 1112204011281 charged pocket; other site 1112204011282 hydrophobic patch; other site 1112204011283 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1112204011284 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1112204011285 MoaD interaction [polypeptide binding]; other site 1112204011286 active site residues [active] 1112204011287 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1112204011288 MPT binding site; other site 1112204011289 trimer interface [polypeptide binding]; other site 1112204011290 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 1112204011291 trimer interface [polypeptide binding]; other site 1112204011292 dimer interface [polypeptide binding]; other site 1112204011293 putative active site [active] 1112204011294 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204011295 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204011296 active site 1112204011297 ATP binding site [chemical binding]; other site 1112204011298 substrate binding site [chemical binding]; other site 1112204011299 activation loop (A-loop); other site 1112204011300 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204011301 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204011302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1112204011303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204011304 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204011305 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1112204011306 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1112204011307 WYL domain; Region: WYL; pfam13280 1112204011308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204011309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204011310 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1112204011311 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1112204011312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204011313 nucleotide binding region [chemical binding]; other site 1112204011314 ATP-binding site [chemical binding]; other site 1112204011315 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204011316 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204011317 active site 1112204011318 ATP binding site [chemical binding]; other site 1112204011319 substrate binding site [chemical binding]; other site 1112204011320 activation loop (A-loop); other site 1112204011321 aminotransferase; Validated; Region: PRK07777 1112204011322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204011323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204011324 homodimer interface [polypeptide binding]; other site 1112204011325 catalytic residue [active] 1112204011326 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1112204011327 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1112204011328 NAD(P) binding site [chemical binding]; other site 1112204011329 substrate binding site [chemical binding]; other site 1112204011330 dimer interface [polypeptide binding]; other site 1112204011331 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1112204011332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204011333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204011334 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1112204011335 classical (c) SDRs; Region: SDR_c; cd05233 1112204011336 NAD(P) binding site [chemical binding]; other site 1112204011337 active site 1112204011338 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1112204011339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204011340 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1112204011341 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1112204011342 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1112204011343 short chain dehydrogenase; Provisional; Region: PRK06197 1112204011344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204011345 NAD(P) binding site [chemical binding]; other site 1112204011346 active site 1112204011347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204011348 dimerization interface [polypeptide binding]; other site 1112204011349 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1112204011350 cyclase homology domain; Region: CHD; cd07302 1112204011351 nucleotidyl binding site; other site 1112204011352 metal binding site [ion binding]; metal-binding site 1112204011353 dimer interface [polypeptide binding]; other site 1112204011354 Secretory lipase; Region: LIP; pfam03583 1112204011355 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1112204011356 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1112204011357 DNA binding residues [nucleotide binding] 1112204011358 putative dimer interface [polypeptide binding]; other site 1112204011359 oxidoreductase; Provisional; Region: PRK06196 1112204011360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204011361 NAD(P) binding site [chemical binding]; other site 1112204011362 active site 1112204011363 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1112204011364 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1112204011365 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1112204011366 ATP binding site [chemical binding]; other site 1112204011367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204011368 salt bridge; other site 1112204011369 non-specific DNA binding site [nucleotide binding]; other site 1112204011370 sequence-specific DNA binding site [nucleotide binding]; other site 1112204011371 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1112204011372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204011373 non-specific DNA binding site [nucleotide binding]; other site 1112204011374 salt bridge; other site 1112204011375 sequence-specific DNA binding site [nucleotide binding]; other site 1112204011376 Helix-turn-helix domain; Region: HTH_17; pfam12728 1112204011377 Replication protein; Region: Rep_1; cl02412 1112204011378 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204011379 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204011380 active site 1112204011381 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1112204011382 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1112204011383 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1112204011384 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1112204011385 putative active site [active] 1112204011386 putative CoA binding site [chemical binding]; other site 1112204011387 nudix motif; other site 1112204011388 metal binding site [ion binding]; metal-binding site 1112204011389 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1112204011390 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1112204011391 Transmembrane secretion effector; Region: MFS_3; pfam05977 1112204011392 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204011393 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1112204011394 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204011395 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204011396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1112204011397 enoyl-CoA hydratase; Provisional; Region: PRK08252 1112204011398 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204011399 substrate binding site [chemical binding]; other site 1112204011400 oxyanion hole (OAH) forming residues; other site 1112204011401 trimer interface [polypeptide binding]; other site 1112204011402 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1112204011403 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1112204011404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204011405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204011406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204011407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204011408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204011409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1112204011410 dimerization interface [polypeptide binding]; other site 1112204011411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204011412 sequence-specific DNA binding site [nucleotide binding]; other site 1112204011413 salt bridge; other site 1112204011414 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1112204011415 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204011416 dimer interface [polypeptide binding]; other site 1112204011417 active site 1112204011418 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1112204011419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204011420 acyl-activating enzyme (AAE) consensus motif; other site 1112204011421 AMP binding site [chemical binding]; other site 1112204011422 active site 1112204011423 CoA binding site [chemical binding]; other site 1112204011424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204011425 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204011426 NAD(P) binding site [chemical binding]; other site 1112204011427 active site 1112204011428 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1112204011429 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204011430 dimer interface [polypeptide binding]; other site 1112204011431 active site 1112204011432 D-galactonate transporter; Region: 2A0114; TIGR00893 1112204011433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204011434 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011435 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011436 active site 1112204011437 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011438 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011439 active site 1112204011440 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204011441 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204011442 active site 1112204011443 NAD synthetase; Reviewed; Region: nadE; PRK02628 1112204011444 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1112204011445 multimer interface [polypeptide binding]; other site 1112204011446 active site 1112204011447 catalytic triad [active] 1112204011448 protein interface 1 [polypeptide binding]; other site 1112204011449 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1112204011450 homodimer interface [polypeptide binding]; other site 1112204011451 NAD binding pocket [chemical binding]; other site 1112204011452 ATP binding pocket [chemical binding]; other site 1112204011453 Mg binding site [ion binding]; other site 1112204011454 active-site loop [active] 1112204011455 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1112204011456 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1112204011457 SnoaL-like domain; Region: SnoaL_4; pfam13577 1112204011458 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1112204011459 homodimer interface [polypeptide binding]; other site 1112204011460 putative substrate binding pocket [chemical binding]; other site 1112204011461 diiron center [ion binding]; other site 1112204011462 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1112204011463 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1112204011464 FMN binding site [chemical binding]; other site 1112204011465 active site 1112204011466 catalytic residues [active] 1112204011467 substrate binding site [chemical binding]; other site 1112204011468 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1112204011469 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1112204011470 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1112204011471 PhoU domain; Region: PhoU; pfam01895 1112204011472 PhoU domain; Region: PhoU; pfam01895 1112204011473 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1112204011474 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1112204011475 Walker A/P-loop; other site 1112204011476 ATP binding site [chemical binding]; other site 1112204011477 Q-loop/lid; other site 1112204011478 ABC transporter signature motif; other site 1112204011479 Walker B; other site 1112204011480 D-loop; other site 1112204011481 H-loop/switch region; other site 1112204011482 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1112204011483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204011484 dimer interface [polypeptide binding]; other site 1112204011485 conserved gate region; other site 1112204011486 putative PBP binding loops; other site 1112204011487 ABC-ATPase subunit interface; other site 1112204011488 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1112204011489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204011490 dimer interface [polypeptide binding]; other site 1112204011491 conserved gate region; other site 1112204011492 putative PBP binding loops; other site 1112204011493 ABC-ATPase subunit interface; other site 1112204011494 PBP superfamily domain; Region: PBP_like_2; cl17296 1112204011495 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1112204011496 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1112204011497 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1112204011498 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1112204011499 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204011500 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1112204011501 putative catalytic site [active] 1112204011502 putative phosphate binding site [ion binding]; other site 1112204011503 putative metal binding site [ion binding]; other site 1112204011504 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1112204011505 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1112204011506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204011507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204011508 DNA binding site [nucleotide binding] 1112204011509 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1112204011510 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1112204011511 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1112204011512 active site residue [active] 1112204011513 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1112204011514 active site residue [active] 1112204011515 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1112204011516 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1112204011517 heme-binding site [chemical binding]; other site 1112204011518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204011519 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1112204011520 Walker A/P-loop; other site 1112204011521 ATP binding site [chemical binding]; other site 1112204011522 Q-loop/lid; other site 1112204011523 ABC transporter signature motif; other site 1112204011524 Walker B; other site 1112204011525 D-loop; other site 1112204011526 H-loop/switch region; other site 1112204011527 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1112204011528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204011529 Walker A/P-loop; other site 1112204011530 ATP binding site [chemical binding]; other site 1112204011531 Q-loop/lid; other site 1112204011532 ABC transporter signature motif; other site 1112204011533 Walker B; other site 1112204011534 D-loop; other site 1112204011535 H-loop/switch region; other site 1112204011536 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1112204011537 AAA domain; Region: AAA_23; pfam13476 1112204011538 Walker A/P-loop; other site 1112204011539 ATP binding site [chemical binding]; other site 1112204011540 ABC transporter; Region: ABC_tran; pfam00005 1112204011541 Q-loop/lid; other site 1112204011542 ABC transporter signature motif; other site 1112204011543 Walker B; other site 1112204011544 D-loop; other site 1112204011545 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1112204011546 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1112204011547 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1112204011548 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1112204011549 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1112204011550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204011551 catalytic residue [active] 1112204011552 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1112204011553 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1112204011554 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1112204011555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1112204011556 MOSC domain; Region: MOSC; pfam03473 1112204011557 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1112204011558 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1112204011559 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1112204011560 dimerization interface [polypeptide binding]; other site 1112204011561 putative ATP binding site [chemical binding]; other site 1112204011562 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1112204011563 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1112204011564 active site 1112204011565 tetramer interface [polypeptide binding]; other site 1112204011566 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204011567 active site 1112204011568 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1112204011569 active site 1112204011570 catalytic triad [active] 1112204011571 oxyanion hole [active] 1112204011572 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1112204011573 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204011574 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204011575 active site 1112204011576 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1112204011577 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1112204011578 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1112204011579 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1112204011580 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1112204011581 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1112204011582 active site 1112204011583 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1112204011584 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1112204011585 dimerization interface [polypeptide binding]; other site 1112204011586 ATP binding site [chemical binding]; other site 1112204011587 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1112204011588 dimerization interface [polypeptide binding]; other site 1112204011589 ATP binding site [chemical binding]; other site 1112204011590 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1112204011591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1112204011592 binding surface 1112204011593 TPR motif; other site 1112204011594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204011595 Walker A motif; other site 1112204011596 ATP binding site [chemical binding]; other site 1112204011597 Walker B motif; other site 1112204011598 arginine finger; other site 1112204011599 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1112204011600 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1112204011601 active site 1112204011602 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1112204011603 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1112204011604 CysD dimerization site [polypeptide binding]; other site 1112204011605 G1 box; other site 1112204011606 putative GEF interaction site [polypeptide binding]; other site 1112204011607 GTP/Mg2+ binding site [chemical binding]; other site 1112204011608 Switch I region; other site 1112204011609 G2 box; other site 1112204011610 G3 box; other site 1112204011611 Switch II region; other site 1112204011612 G4 box; other site 1112204011613 G5 box; other site 1112204011614 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1112204011615 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1112204011616 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1112204011617 ligand-binding site [chemical binding]; other site 1112204011618 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1112204011619 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1112204011620 Active Sites [active] 1112204011621 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204011622 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204011623 enoyl-CoA hydratase; Provisional; Region: PRK08290 1112204011624 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204011625 substrate binding site [chemical binding]; other site 1112204011626 oxyanion hole (OAH) forming residues; other site 1112204011627 trimer interface [polypeptide binding]; other site 1112204011628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011629 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011630 active site 1112204011631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011633 active site 1112204011634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011636 active site 1112204011637 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1112204011638 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204011639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204011640 non-specific DNA binding site [nucleotide binding]; other site 1112204011641 salt bridge; other site 1112204011642 sequence-specific DNA binding site [nucleotide binding]; other site 1112204011643 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1112204011644 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1112204011645 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1112204011646 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1112204011647 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204011648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204011649 NAD(P) binding site [chemical binding]; other site 1112204011650 active site 1112204011651 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204011652 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1112204011653 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1112204011654 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1112204011655 active site 1112204011656 Fe binding site [ion binding]; other site 1112204011657 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011658 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1112204011659 Flavin binding site [chemical binding]; other site 1112204011660 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1112204011661 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1112204011662 iron-sulfur cluster [ion binding]; other site 1112204011663 [2Fe-2S] cluster binding site [ion binding]; other site 1112204011664 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1112204011665 hydrophobic ligand binding site; other site 1112204011666 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1112204011667 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1112204011668 gating phenylalanine in ion channel; other site 1112204011669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204011670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204011671 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1112204011672 putative dimerization interface [polypeptide binding]; other site 1112204011673 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1112204011674 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1112204011675 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204011676 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1112204011677 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1112204011678 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1112204011679 active site 1112204011680 catalytic residues [active] 1112204011681 metal binding site [ion binding]; metal-binding site 1112204011682 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1112204011683 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1112204011684 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1112204011685 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1112204011686 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1112204011687 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1112204011688 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1112204011689 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1112204011690 hydrophobic ligand binding site; other site 1112204011691 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011692 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011693 active site 1112204011694 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1112204011695 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1112204011696 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1112204011697 active site 1112204011698 Fe binding site [ion binding]; other site 1112204011699 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204011700 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1112204011701 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204011702 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204011703 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204011704 Predicted transcriptional regulators [Transcription]; Region: COG1695 1112204011705 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1112204011706 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204011707 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1112204011708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1112204011709 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781 1112204011710 active site/substrate binding site [active] 1112204011711 dimer interface [polypeptide binding]; other site 1112204011712 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 1112204011713 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1112204011714 classical (c) SDRs; Region: SDR_c; cd05233 1112204011715 NAD(P) binding site [chemical binding]; other site 1112204011716 active site 1112204011717 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1112204011718 classical (c) SDRs; Region: SDR_c; cd05233 1112204011719 NAD(P) binding site [chemical binding]; other site 1112204011720 active site 1112204011721 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204011722 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1112204011723 FAD binding pocket [chemical binding]; other site 1112204011724 FAD binding motif [chemical binding]; other site 1112204011725 phosphate binding motif [ion binding]; other site 1112204011726 beta-alpha-beta structure motif; other site 1112204011727 NAD(p) ribose binding residues [chemical binding]; other site 1112204011728 NAD binding pocket [chemical binding]; other site 1112204011729 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1112204011730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204011731 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1112204011732 catalytic loop [active] 1112204011733 iron binding site [ion binding]; other site 1112204011734 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011735 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011736 active site 1112204011737 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011738 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204011739 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1112204011740 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1112204011741 L-aspartate oxidase; Provisional; Region: PRK06175 1112204011742 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1112204011743 enoyl-CoA hydratase; Region: PLN02864 1112204011744 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1112204011745 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1112204011746 dimer interaction site [polypeptide binding]; other site 1112204011747 substrate-binding tunnel; other site 1112204011748 active site 1112204011749 catalytic site [active] 1112204011750 substrate binding site [chemical binding]; other site 1112204011751 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1112204011752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204011753 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1112204011754 classical (c) SDRs; Region: SDR_c; cd05233 1112204011755 NAD(P) binding site [chemical binding]; other site 1112204011756 active site 1112204011757 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1112204011758 classical (c) SDRs; Region: SDR_c; cd05233 1112204011759 NAD(P) binding site [chemical binding]; other site 1112204011760 active site 1112204011761 MoxR-like ATPases [General function prediction only]; Region: COG0714 1112204011762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204011763 Walker A motif; other site 1112204011764 ATP binding site [chemical binding]; other site 1112204011765 Walker B motif; other site 1112204011766 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1112204011767 metal ion-dependent adhesion site (MIDAS); other site 1112204011768 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1112204011769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204011770 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1112204011771 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1112204011772 transmembrane helices; other site 1112204011773 acyl-CoA synthetase; Validated; Region: PRK07798 1112204011774 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204011775 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1112204011776 acyl-activating enzyme (AAE) consensus motif; other site 1112204011777 putative AMP binding site [chemical binding]; other site 1112204011778 putative active site [active] 1112204011779 putative CoA binding site [chemical binding]; other site 1112204011780 lipid-transfer protein; Provisional; Region: PRK07855 1112204011781 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1112204011782 active site 1112204011783 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1112204011784 putative active site [active] 1112204011785 putative catalytic site [active] 1112204011786 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204011787 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1112204011788 DUF35 OB-fold domain; Region: DUF35; pfam01796 1112204011789 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011790 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011791 active site 1112204011792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011793 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204011794 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011795 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204011796 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011797 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011798 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204011799 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204011800 active site 1112204011801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204011802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204011803 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1112204011804 Putative esterase; Region: Esterase; pfam00756 1112204011805 S-formylglutathione hydrolase; Region: PLN02442 1112204011806 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1112204011807 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204011808 NAD(P) binding site [chemical binding]; other site 1112204011809 catalytic residues [active] 1112204011810 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1112204011811 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1112204011812 NAD binding site [chemical binding]; other site 1112204011813 catalytic Zn binding site [ion binding]; other site 1112204011814 substrate binding site [chemical binding]; other site 1112204011815 structural Zn binding site [ion binding]; other site 1112204011816 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1112204011817 [2Fe-2S] cluster binding site [ion binding]; other site 1112204011818 iron-sulfur cluster [ion binding]; other site 1112204011819 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204011820 MULE transposase domain; Region: MULE; pfam10551 1112204011821 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204011822 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1112204011823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204011824 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204011825 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1112204011826 acyl-activating enzyme (AAE) consensus motif; other site 1112204011827 AMP binding site [chemical binding]; other site 1112204011828 active site 1112204011829 CoA binding site [chemical binding]; other site 1112204011830 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1112204011831 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1112204011832 FAD binding pocket [chemical binding]; other site 1112204011833 FAD binding motif [chemical binding]; other site 1112204011834 phosphate binding motif [ion binding]; other site 1112204011835 beta-alpha-beta structure motif; other site 1112204011836 NAD(p) ribose binding residues [chemical binding]; other site 1112204011837 NAD binding pocket [chemical binding]; other site 1112204011838 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1112204011839 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204011840 catalytic loop [active] 1112204011841 iron binding site [ion binding]; other site 1112204011842 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1112204011843 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1112204011844 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1112204011845 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1112204011846 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1112204011847 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1112204011848 enoyl-CoA hydratase; Provisional; Region: PRK08140 1112204011849 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204011850 substrate binding site [chemical binding]; other site 1112204011851 oxyanion hole (OAH) forming residues; other site 1112204011852 trimer interface [polypeptide binding]; other site 1112204011853 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1112204011854 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1112204011855 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1112204011856 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1112204011857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204011858 substrate binding site [chemical binding]; other site 1112204011859 oxyanion hole (OAH) forming residues; other site 1112204011860 trimer interface [polypeptide binding]; other site 1112204011861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204011862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204011863 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1112204011864 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1112204011865 substrate binding site [chemical binding]; other site 1112204011866 dimer interface [polypeptide binding]; other site 1112204011867 NADP binding site [chemical binding]; other site 1112204011868 catalytic residues [active] 1112204011869 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204011870 active site 2 [active] 1112204011871 active site 1 [active] 1112204011872 EthD domain; Region: EthD; cl17553 1112204011873 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204011874 CoenzymeA binding site [chemical binding]; other site 1112204011875 subunit interaction site [polypeptide binding]; other site 1112204011876 PHB binding site; other site 1112204011877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1112204011878 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1112204011879 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1112204011880 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1112204011881 putative NAD(P) binding site [chemical binding]; other site 1112204011882 Isochorismatase family; Region: Isochorismatase; pfam00857 1112204011883 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1112204011884 catalytic triad [active] 1112204011885 conserved cis-peptide bond; other site 1112204011886 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1112204011887 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1112204011888 conserved cys residue [active] 1112204011889 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1112204011890 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204011891 acyl-activating enzyme (AAE) consensus motif; other site 1112204011892 AMP binding site [chemical binding]; other site 1112204011893 active site 1112204011894 CoA binding site [chemical binding]; other site 1112204011895 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1112204011896 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1112204011897 active site 2 [active] 1112204011898 active site 1 [active] 1112204011899 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1112204011900 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204011901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204011902 DNA-binding site [nucleotide binding]; DNA binding site 1112204011903 H+ Antiporter protein; Region: 2A0121; TIGR00900 1112204011904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204011905 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1112204011906 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1112204011907 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1112204011908 active site 1112204011909 catalytic triad [active] 1112204011910 oxyanion hole [active] 1112204011911 enoyl-CoA hydratase; Provisional; Region: PRK08260 1112204011912 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204011913 substrate binding site [chemical binding]; other site 1112204011914 oxyanion hole (OAH) forming residues; other site 1112204011915 trimer interface [polypeptide binding]; other site 1112204011916 Clp protease ATP binding subunit; Region: clpC; CHL00095 1112204011917 Clp amino terminal domain; Region: Clp_N; pfam02861 1112204011918 Clp amino terminal domain; Region: Clp_N; pfam02861 1112204011919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204011920 Walker A motif; other site 1112204011921 ATP binding site [chemical binding]; other site 1112204011922 Walker B motif; other site 1112204011923 arginine finger; other site 1112204011924 UvrB/uvrC motif; Region: UVR; pfam02151 1112204011925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204011926 Walker A motif; other site 1112204011927 ATP binding site [chemical binding]; other site 1112204011928 Walker B motif; other site 1112204011929 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1112204011930 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1112204011931 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1112204011932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204011933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204011934 DNA binding residues [nucleotide binding] 1112204011935 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1112204011936 putative dimer interface [polypeptide binding]; other site 1112204011937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204011938 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204011939 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204011940 active site 1112204011941 Predicted transcriptional regulators [Transcription]; Region: COG1733 1112204011942 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1112204011943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204011944 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1112204011945 NAD(P) binding site [chemical binding]; other site 1112204011946 active site 1112204011947 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1112204011948 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1112204011949 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1112204011950 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1112204011951 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1112204011952 active site 1112204011953 metal binding site [ion binding]; metal-binding site 1112204011954 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1112204011955 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1112204011956 putative active site [active] 1112204011957 catalytic triad [active] 1112204011958 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1112204011959 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1112204011960 catalytic residues [active] 1112204011961 dimer interface [polypeptide binding]; other site 1112204011962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204011963 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204011964 putative Zn2+ binding site [ion binding]; other site 1112204011965 putative DNA binding site [nucleotide binding]; other site 1112204011966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204011967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204011968 putative substrate translocation pore; other site 1112204011969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204011970 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1112204011971 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204011972 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1112204011973 ATP binding site [chemical binding]; other site 1112204011974 active site 1112204011975 substrate binding site [chemical binding]; other site 1112204011976 active site 1112204011977 metal binding site [ion binding]; metal-binding site 1112204011978 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1112204011979 adenylosuccinate lyase; Region: purB; TIGR00928 1112204011980 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1112204011981 tetramer interface [polypeptide binding]; other site 1112204011982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1112204011983 MMPL family; Region: MMPL; pfam03176 1112204011984 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1112204011985 putative homodimer interface [polypeptide binding]; other site 1112204011986 putative homotetramer interface [polypeptide binding]; other site 1112204011987 putative allosteric switch controlling residues; other site 1112204011988 putative metal binding site [ion binding]; other site 1112204011989 putative homodimer-homodimer interface [polypeptide binding]; other site 1112204011990 Domain of unknown function DUF302; Region: DUF302; pfam03625 1112204011991 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1112204011992 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1112204011993 Putative esterase; Region: Esterase; pfam00756 1112204011994 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1112204011995 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1112204011996 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1112204011997 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1112204011998 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1112204011999 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1112204012000 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1112204012001 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 1112204012002 Ligand binding site; other site 1112204012003 Ligand binding site; other site 1112204012004 Ligand binding site; other site 1112204012005 Putative Catalytic site; other site 1112204012006 DXD motif; other site 1112204012007 Predicted membrane protein [Function unknown]; Region: COG2246 1112204012008 GtrA-like protein; Region: GtrA; pfam04138 1112204012009 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1112204012010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1112204012011 ATP binding site [chemical binding]; other site 1112204012012 putative Mg++ binding site [ion binding]; other site 1112204012013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1112204012014 nucleotide binding region [chemical binding]; other site 1112204012015 ATP-binding site [chemical binding]; other site 1112204012016 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1112204012017 nucleotide binding site/active site [active] 1112204012018 HIT family signature motif; other site 1112204012019 catalytic residue [active] 1112204012020 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1112204012021 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1112204012022 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1112204012023 putative active site [active] 1112204012024 putative metal binding site [ion binding]; other site 1112204012025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1112204012026 dimerization interface [polypeptide binding]; other site 1112204012027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1112204012028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204012029 dimer interface [polypeptide binding]; other site 1112204012030 phosphorylation site [posttranslational modification] 1112204012031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204012032 ATP binding site [chemical binding]; other site 1112204012033 Mg2+ binding site [ion binding]; other site 1112204012034 G-X-G motif; other site 1112204012035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204012036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204012037 active site 1112204012038 phosphorylation site [posttranslational modification] 1112204012039 intermolecular recognition site; other site 1112204012040 dimerization interface [polypeptide binding]; other site 1112204012041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204012042 DNA binding site [nucleotide binding] 1112204012043 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1112204012044 putative hydrophobic ligand binding site [chemical binding]; other site 1112204012045 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1112204012046 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1112204012047 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1112204012048 homotrimer interaction site [polypeptide binding]; other site 1112204012049 putative active site [active] 1112204012050 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204012051 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204012052 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204012053 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204012054 active site 1112204012055 selenocysteine synthase; Provisional; Region: PRK04311 1112204012056 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1112204012057 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204012058 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1112204012059 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1112204012060 G1 box; other site 1112204012061 putative GEF interaction site [polypeptide binding]; other site 1112204012062 GTP/Mg2+ binding site [chemical binding]; other site 1112204012063 Switch I region; other site 1112204012064 G2 box; other site 1112204012065 G3 box; other site 1112204012066 Switch II region; other site 1112204012067 G4 box; other site 1112204012068 G5 box; other site 1112204012069 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1112204012070 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1112204012071 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1112204012072 DNA repair protein RadA; Provisional; Region: PRK11823 1112204012073 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1112204012074 Walker A motif; other site 1112204012075 ATP binding site [chemical binding]; other site 1112204012076 Walker B motif; other site 1112204012077 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1112204012078 Predicted esterase [General function prediction only]; Region: COG0627 1112204012079 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204012080 CoenzymeA binding site [chemical binding]; other site 1112204012081 subunit interaction site [polypeptide binding]; other site 1112204012082 PHB binding site; other site 1112204012083 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1112204012084 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1112204012085 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1112204012086 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1112204012087 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204012088 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204012089 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204012090 active site 1112204012091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1112204012092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1112204012093 DNA binding site [nucleotide binding] 1112204012094 domain linker motif; other site 1112204012095 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1112204012096 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1112204012097 active site clefts [active] 1112204012098 zinc binding site [ion binding]; other site 1112204012099 dimer interface [polypeptide binding]; other site 1112204012100 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1112204012101 endonuclease III; Region: ENDO3c; smart00478 1112204012102 minor groove reading motif; other site 1112204012103 helix-hairpin-helix signature motif; other site 1112204012104 substrate binding pocket [chemical binding]; other site 1112204012105 active site 1112204012106 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1112204012107 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1112204012108 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204012109 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1112204012110 catalytic site [active] 1112204012111 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1112204012112 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1112204012113 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1112204012114 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204012115 NAD binding site [chemical binding]; other site 1112204012116 catalytic residues [active] 1112204012117 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204012118 mce related protein; Region: MCE; pfam02470 1112204012119 mce related protein; Region: MCE; pfam02470 1112204012120 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204012121 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204012122 mce related protein; Region: MCE; pfam02470 1112204012123 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204012124 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204012125 mce related protein; Region: MCE; pfam02470 1112204012126 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1112204012127 mce related protein; Region: MCE; pfam02470 1112204012128 mce related protein; Region: MCE; pfam02470 1112204012129 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204012130 Permease; Region: Permease; pfam02405 1112204012131 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1112204012132 Permease; Region: Permease; pfam02405 1112204012133 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1112204012134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204012135 NAD(P) binding site [chemical binding]; other site 1112204012136 active site 1112204012137 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204012138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204012139 active site 1112204012140 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204012141 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1112204012142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204012143 active site 1112204012144 acyl-CoA synthetase; Validated; Region: PRK07867 1112204012145 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204012146 acyl-activating enzyme (AAE) consensus motif; other site 1112204012147 AMP binding site [chemical binding]; other site 1112204012148 active site 1112204012149 CoA binding site [chemical binding]; other site 1112204012150 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204012151 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204012152 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204012153 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204012154 active site 1112204012155 Nitronate monooxygenase; Region: NMO; pfam03060 1112204012156 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1112204012157 FMN binding site [chemical binding]; other site 1112204012158 substrate binding site [chemical binding]; other site 1112204012159 putative catalytic residue [active] 1112204012160 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204012161 AMP-binding enzyme; Region: AMP-binding; pfam00501 1112204012162 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204012163 acyl-activating enzyme (AAE) consensus motif; other site 1112204012164 acyl-activating enzyme (AAE) consensus motif; other site 1112204012165 active site 1112204012166 AMP binding site [chemical binding]; other site 1112204012167 CoA binding site [chemical binding]; other site 1112204012168 enoyl-CoA hydratase; Provisional; Region: PRK07799 1112204012169 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204012170 substrate binding site [chemical binding]; other site 1112204012171 oxyanion hole (OAH) forming residues; other site 1112204012172 trimer interface [polypeptide binding]; other site 1112204012173 Cytochrome P450; Region: p450; cl12078 1112204012174 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204012175 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1112204012176 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204012177 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204012178 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1112204012179 DUF35 OB-fold domain; Region: DUF35; pfam01796 1112204012180 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1112204012181 DUF35 OB-fold domain; Region: DUF35; pfam01796 1112204012182 lipid-transfer protein; Provisional; Region: PRK07937 1112204012183 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1112204012184 active site 1112204012185 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1112204012186 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1112204012187 active site 1112204012188 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1112204012189 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1112204012190 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204012191 Cytochrome P450; Region: p450; cl12078 1112204012192 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1112204012193 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204012194 dimer interface [polypeptide binding]; other site 1112204012195 active site 1112204012196 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1112204012197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204012198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204012199 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204012200 Cytochrome P450; Region: p450; cl12078 1112204012201 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1112204012202 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1112204012203 DXD motif; other site 1112204012204 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1112204012205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1112204012206 active site 1112204012207 Condensation domain; Region: Condensation; pfam00668 1112204012208 Condensation domain; Region: Condensation; pfam00668 1112204012209 Condensation domain; Region: Condensation; pfam00668 1112204012210 Predicted esterase [General function prediction only]; Region: COG0627 1112204012211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204012212 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1112204012213 Walker A/P-loop; other site 1112204012214 ATP binding site [chemical binding]; other site 1112204012215 Q-loop/lid; other site 1112204012216 ABC transporter signature motif; other site 1112204012217 Walker B; other site 1112204012218 D-loop; other site 1112204012219 H-loop/switch region; other site 1112204012220 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1112204012221 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204012222 peptide synthase; Provisional; Region: PRK12316 1112204012223 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1112204012224 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1112204012225 homodimer interface [polypeptide binding]; other site 1112204012226 active site 1112204012227 TDP-binding site; other site 1112204012228 acceptor substrate-binding pocket; other site 1112204012229 acyl-CoA synthetase; Validated; Region: PRK06188 1112204012230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204012231 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204012232 putative active site [active] 1112204012233 putative CoA binding site [chemical binding]; other site 1112204012234 putative AMP binding site [chemical binding]; other site 1112204012235 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1112204012236 primary dimer interface [polypeptide binding]; other site 1112204012237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1112204012238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204012239 Coenzyme A binding pocket [chemical binding]; other site 1112204012240 short chain dehydrogenase; Provisional; Region: PRK07791 1112204012241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204012242 NAD(P) binding site [chemical binding]; other site 1112204012243 active site 1112204012244 short chain dehydrogenase; Provisional; Region: PRK07856 1112204012245 classical (c) SDRs; Region: SDR_c; cd05233 1112204012246 NAD(P) binding site [chemical binding]; other site 1112204012247 active site 1112204012248 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204012249 substrate binding site [chemical binding]; other site 1112204012250 oxyanion hole (OAH) forming residues; other site 1112204012251 trimer interface [polypeptide binding]; other site 1112204012252 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1112204012253 Coenzyme A transferase; Region: CoA_trans; cl17247 1112204012254 Nitronate monooxygenase; Region: NMO; pfam03060 1112204012255 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1112204012256 FMN binding site [chemical binding]; other site 1112204012257 substrate binding site [chemical binding]; other site 1112204012258 putative catalytic residue [active] 1112204012259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1112204012260 Predicted ATPase [General function prediction only]; Region: COG1485 1112204012261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204012262 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1112204012263 NAD(P) binding site [chemical binding]; other site 1112204012264 active site 1112204012265 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1112204012266 classical (c) SDRs; Region: SDR_c; cd05233 1112204012267 NAD(P) binding site [chemical binding]; other site 1112204012268 active site 1112204012269 acyl-CoA synthetase; Validated; Region: PRK08316 1112204012270 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204012271 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204012272 acyl-activating enzyme (AAE) consensus motif; other site 1112204012273 putative AMP binding site [chemical binding]; other site 1112204012274 putative active site [active] 1112204012275 putative CoA binding site [chemical binding]; other site 1112204012276 acyl-CoA synthetase; Validated; Region: PRK07788 1112204012277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204012278 acyl-activating enzyme (AAE) consensus motif; other site 1112204012279 AMP binding site [chemical binding]; other site 1112204012280 active site 1112204012281 CoA binding site [chemical binding]; other site 1112204012282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204012283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204012284 Walker A/P-loop; other site 1112204012285 ATP binding site [chemical binding]; other site 1112204012286 Q-loop/lid; other site 1112204012287 ABC transporter signature motif; other site 1112204012288 Walker B; other site 1112204012289 D-loop; other site 1112204012290 H-loop/switch region; other site 1112204012291 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1112204012292 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1112204012293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204012294 Walker A/P-loop; other site 1112204012295 ATP binding site [chemical binding]; other site 1112204012296 Q-loop/lid; other site 1112204012297 ABC transporter signature motif; other site 1112204012298 Walker B; other site 1112204012299 D-loop; other site 1112204012300 H-loop/switch region; other site 1112204012301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204012302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204012303 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1112204012304 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1112204012305 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1112204012306 NAD(P) binding site [chemical binding]; other site 1112204012307 catalytic residues [active] 1112204012308 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1112204012309 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204012310 dimer interface [polypeptide binding]; other site 1112204012311 active site 1112204012312 short chain dehydrogenase; Provisional; Region: PRK07831 1112204012313 classical (c) SDRs; Region: SDR_c; cd05233 1112204012314 NAD(P) binding site [chemical binding]; other site 1112204012315 active site 1112204012316 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204012317 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1112204012318 active site 1112204012319 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1112204012320 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204012321 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1112204012322 acyl-activating enzyme (AAE) consensus motif; other site 1112204012323 putative AMP binding site [chemical binding]; other site 1112204012324 putative active site [active] 1112204012325 putative CoA binding site [chemical binding]; other site 1112204012326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1112204012327 AAA domain; Region: AAA_33; pfam13671 1112204012328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1112204012329 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1112204012330 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1112204012331 dimer interface [polypeptide binding]; other site 1112204012332 putative anticodon binding site; other site 1112204012333 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1112204012334 motif 1; other site 1112204012335 dimer interface [polypeptide binding]; other site 1112204012336 active site 1112204012337 motif 2; other site 1112204012338 motif 3; other site 1112204012339 pantothenate kinase; Reviewed; Region: PRK13318 1112204012340 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1112204012341 tetramerization interface [polypeptide binding]; other site 1112204012342 active site 1112204012343 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1112204012344 active site 1112204012345 ATP-binding site [chemical binding]; other site 1112204012346 pantoate-binding site; other site 1112204012347 HXXH motif; other site 1112204012348 Rossmann-like domain; Region: Rossmann-like; pfam10727 1112204012349 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1112204012350 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1112204012351 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1112204012352 catalytic center binding site [active] 1112204012353 ATP binding site [chemical binding]; other site 1112204012354 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1112204012355 homooctamer interface [polypeptide binding]; other site 1112204012356 active site 1112204012357 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1112204012358 dihydropteroate synthase; Region: DHPS; TIGR01496 1112204012359 substrate binding pocket [chemical binding]; other site 1112204012360 inhibitor binding site; inhibition site 1112204012361 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1112204012362 GTP cyclohydrolase I; Provisional; Region: PLN03044 1112204012363 homodecamer interface [polypeptide binding]; other site 1112204012364 active site 1112204012365 putative catalytic site residues [active] 1112204012366 zinc binding site [ion binding]; other site 1112204012367 GTP-CH-I/GFRP interaction surface; other site 1112204012368 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1112204012369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204012370 Walker A motif; other site 1112204012371 ATP binding site [chemical binding]; other site 1112204012372 Walker B motif; other site 1112204012373 arginine finger; other site 1112204012374 Peptidase family M41; Region: Peptidase_M41; pfam01434 1112204012375 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204012376 active site 1112204012377 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1112204012378 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1112204012379 Ligand Binding Site [chemical binding]; other site 1112204012380 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1112204012381 putative hydrolase; Region: TIGR03624 1112204012382 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1112204012383 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1112204012384 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1112204012385 dimer interface [polypeptide binding]; other site 1112204012386 substrate binding site [chemical binding]; other site 1112204012387 metal binding sites [ion binding]; metal-binding site 1112204012388 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1112204012389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204012390 putative substrate translocation pore; other site 1112204012391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204012392 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1112204012393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204012394 putative Zn2+ binding site [ion binding]; other site 1112204012395 putative DNA binding site [nucleotide binding]; other site 1112204012396 allantoicase; Provisional; Region: PRK13257 1112204012397 Allantoicase repeat; Region: Allantoicase; pfam03561 1112204012398 Allantoicase repeat; Region: Allantoicase; pfam03561 1112204012399 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204012400 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1112204012401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204012402 catalytic residue [active] 1112204012403 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1112204012404 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1112204012405 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1112204012406 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204012407 active site 1112204012408 ATP binding site [chemical binding]; other site 1112204012409 substrate binding site [chemical binding]; other site 1112204012410 activation loop (A-loop); other site 1112204012411 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1112204012412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204012413 Coenzyme A binding pocket [chemical binding]; other site 1112204012414 DNA gyrase, A subunit; Region: gyrA; TIGR01063 1112204012415 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1112204012416 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1112204012417 homodimer interface [polypeptide binding]; other site 1112204012418 substrate-cofactor binding pocket; other site 1112204012419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204012420 catalytic residue [active] 1112204012421 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1112204012422 active site residue [active] 1112204012423 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 1112204012424 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1112204012425 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1112204012426 intersubunit interface [polypeptide binding]; other site 1112204012427 ferredoxin-NADP+ reductase; Region: PLN02852 1112204012428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204012429 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1112204012430 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1112204012431 ABC-ATPase subunit interface; other site 1112204012432 dimer interface [polypeptide binding]; other site 1112204012433 putative PBP binding regions; other site 1112204012434 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1112204012435 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1112204012436 ABC-ATPase subunit interface; other site 1112204012437 dimer interface [polypeptide binding]; other site 1112204012438 putative PBP binding regions; other site 1112204012439 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1112204012440 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1112204012441 Walker A/P-loop; other site 1112204012442 ATP binding site [chemical binding]; other site 1112204012443 Q-loop/lid; other site 1112204012444 ABC transporter signature motif; other site 1112204012445 Walker B; other site 1112204012446 D-loop; other site 1112204012447 H-loop/switch region; other site 1112204012448 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1112204012449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204012450 ATP-grasp domain; Region: ATP-grasp; pfam02222 1112204012451 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1112204012452 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1112204012453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204012454 dimerization interface [polypeptide binding]; other site 1112204012455 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1112204012456 cyclase homology domain; Region: CHD; cd07302 1112204012457 nucleotidyl binding site; other site 1112204012458 metal binding site [ion binding]; metal-binding site 1112204012459 dimer interface [polypeptide binding]; other site 1112204012460 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1112204012461 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1112204012462 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204012463 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1112204012464 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1112204012465 Na binding site [ion binding]; other site 1112204012466 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1112204012467 agmatinase; Region: agmatinase; TIGR01230 1112204012468 oligomer interface [polypeptide binding]; other site 1112204012469 putative active site [active] 1112204012470 Mn binding site [ion binding]; other site 1112204012471 SnoaL-like domain; Region: SnoaL_3; pfam13474 1112204012472 Putative esterase; Region: Esterase; pfam00756 1112204012473 S-formylglutathione hydrolase; Region: PLN02442 1112204012474 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204012475 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1112204012476 NAD(P) binding site [chemical binding]; other site 1112204012477 catalytic residues [active] 1112204012478 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1112204012479 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1112204012480 GDP-binding site [chemical binding]; other site 1112204012481 ACT binding site; other site 1112204012482 IMP binding site; other site 1112204012483 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1112204012484 Peptidase family M50; Region: Peptidase_M50; pfam02163 1112204012485 active site 1112204012486 putative substrate binding region [chemical binding]; other site 1112204012487 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1112204012488 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1112204012489 amidase; Validated; Region: PRK06565 1112204012490 Amidase; Region: Amidase; cl11426 1112204012491 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1112204012492 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1112204012493 active site 1112204012494 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204012495 catalytic loop [active] 1112204012496 iron binding site [ion binding]; other site 1112204012497 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1112204012498 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204012499 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204012500 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1112204012501 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204012502 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204012503 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204012504 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1112204012505 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1112204012506 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1112204012507 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1112204012508 active site 1112204012509 intersubunit interface [polypeptide binding]; other site 1112204012510 zinc binding site [ion binding]; other site 1112204012511 Na+ binding site [ion binding]; other site 1112204012512 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1112204012513 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1112204012514 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1112204012515 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1112204012516 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1112204012517 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1112204012518 active site 1112204012519 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1112204012520 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1112204012521 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204012522 active site 1112204012523 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1112204012524 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1112204012525 NAD binding site [chemical binding]; other site 1112204012526 ligand binding site [chemical binding]; other site 1112204012527 catalytic site [active] 1112204012528 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1112204012529 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1112204012530 conserved cys residue [active] 1112204012531 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1112204012532 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204012533 putative DNA binding site [nucleotide binding]; other site 1112204012534 putative Zn2+ binding site [ion binding]; other site 1112204012535 Predicted membrane protein [Function unknown]; Region: COG2246 1112204012536 GtrA-like protein; Region: GtrA; pfam04138 1112204012537 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1112204012538 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204012539 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1112204012540 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204012541 inhibitor-cofactor binding pocket; inhibition site 1112204012542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204012543 catalytic residue [active] 1112204012544 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1112204012545 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204012546 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1112204012547 succinic semialdehyde dehydrogenase; Region: PLN02278 1112204012548 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1112204012549 tetramerization interface [polypeptide binding]; other site 1112204012550 NAD(P) binding site [chemical binding]; other site 1112204012551 catalytic residues [active] 1112204012552 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 1112204012553 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1112204012554 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1112204012555 active site 1112204012556 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1112204012557 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204012558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204012559 homodimer interface [polypeptide binding]; other site 1112204012560 catalytic residue [active] 1112204012561 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1112204012562 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1112204012563 metal binding site [ion binding]; metal-binding site 1112204012564 dimer interface [polypeptide binding]; other site 1112204012565 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1112204012566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204012567 metabolite-proton symporter; Region: 2A0106; TIGR00883 1112204012568 putative substrate translocation pore; other site 1112204012569 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204012570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204012571 DNA-binding site [nucleotide binding]; DNA binding site 1112204012572 FCD domain; Region: FCD; pfam07729 1112204012573 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1112204012574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204012575 active site 1112204012576 phosphorylation site [posttranslational modification] 1112204012577 intermolecular recognition site; other site 1112204012578 dimerization interface [polypeptide binding]; other site 1112204012579 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204012580 DNA binding site [nucleotide binding] 1112204012581 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1112204012582 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1112204012583 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1112204012584 Ligand Binding Site [chemical binding]; other site 1112204012585 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1112204012586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204012587 dimer interface [polypeptide binding]; other site 1112204012588 phosphorylation site [posttranslational modification] 1112204012589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204012590 ATP binding site [chemical binding]; other site 1112204012591 Mg2+ binding site [ion binding]; other site 1112204012592 G-X-G motif; other site 1112204012593 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1112204012594 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1112204012595 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1112204012596 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1112204012597 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1112204012598 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1112204012599 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1112204012600 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1112204012601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204012602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204012603 DNA binding residues [nucleotide binding] 1112204012604 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204012605 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1112204012606 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204012607 active site 1112204012608 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1112204012609 Clp amino terminal domain; Region: Clp_N; pfam02861 1112204012610 Clp amino terminal domain; Region: Clp_N; pfam02861 1112204012611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204012612 Walker A motif; other site 1112204012613 ATP binding site [chemical binding]; other site 1112204012614 Walker B motif; other site 1112204012615 arginine finger; other site 1112204012616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204012617 Walker A motif; other site 1112204012618 ATP binding site [chemical binding]; other site 1112204012619 Walker B motif; other site 1112204012620 arginine finger; other site 1112204012621 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1112204012622 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1112204012623 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1112204012624 active site 1112204012625 Predicted peptidase [General function prediction only]; Region: COG4099 1112204012626 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1112204012627 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1112204012628 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1112204012629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204012630 dimerization interface [polypeptide binding]; other site 1112204012631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204012632 dimer interface [polypeptide binding]; other site 1112204012633 phosphorylation site [posttranslational modification] 1112204012634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204012635 ATP binding site [chemical binding]; other site 1112204012636 Mg2+ binding site [ion binding]; other site 1112204012637 G-X-G motif; other site 1112204012638 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1112204012639 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1112204012640 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1112204012641 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 1112204012642 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1112204012643 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1112204012644 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1112204012645 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1112204012646 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1112204012647 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1112204012648 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1112204012649 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1112204012650 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1112204012651 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1112204012652 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1112204012653 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1112204012654 Imelysin; Region: Peptidase_M75; pfam09375 1112204012655 Iron permease FTR1 family; Region: FTR1; cl00475 1112204012656 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1112204012657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1112204012658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204012659 dimerization interface [polypeptide binding]; other site 1112204012660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204012661 dimer interface [polypeptide binding]; other site 1112204012662 phosphorylation site [posttranslational modification] 1112204012663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204012664 ATP binding site [chemical binding]; other site 1112204012665 Mg2+ binding site [ion binding]; other site 1112204012666 G-X-G motif; other site 1112204012667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1112204012668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204012669 active site 1112204012670 phosphorylation site [posttranslational modification] 1112204012671 intermolecular recognition site; other site 1112204012672 dimerization interface [polypeptide binding]; other site 1112204012673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1112204012674 DNA binding site [nucleotide binding] 1112204012675 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1112204012676 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1112204012677 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1112204012678 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1112204012679 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1112204012680 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1112204012681 conserved cys residue [active] 1112204012682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204012683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204012684 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1112204012685 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1112204012686 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1112204012687 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1112204012688 active site 1112204012689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204012690 Putative esterase; Region: Esterase; pfam00756 1112204012691 Condensation domain; Region: Condensation; pfam00668 1112204012692 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1112204012693 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1112204012694 acyl-activating enzyme (AAE) consensus motif; other site 1112204012695 AMP binding site [chemical binding]; other site 1112204012696 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1112204012697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1112204012698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1112204012699 dimerization interface [polypeptide binding]; other site 1112204012700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1112204012701 dimer interface [polypeptide binding]; other site 1112204012702 phosphorylation site [posttranslational modification] 1112204012703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204012704 ATP binding site [chemical binding]; other site 1112204012705 Mg2+ binding site [ion binding]; other site 1112204012706 G-X-G motif; other site 1112204012707 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1112204012708 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1112204012709 PYR/PP interface [polypeptide binding]; other site 1112204012710 dimer interface [polypeptide binding]; other site 1112204012711 TPP binding site [chemical binding]; other site 1112204012712 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1112204012713 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1112204012714 TPP-binding site [chemical binding]; other site 1112204012715 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1112204012716 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1112204012717 active site 1112204012718 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1112204012719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204012720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204012721 homodimer interface [polypeptide binding]; other site 1112204012722 catalytic residue [active] 1112204012723 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1112204012724 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1112204012725 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1112204012726 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1112204012727 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1112204012728 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1112204012729 NAD(P) binding site [chemical binding]; other site 1112204012730 catalytic residues [active] 1112204012731 Cupin domain; Region: Cupin_2; pfam07883 1112204012732 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1112204012733 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204012734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204012735 DNA-binding site [nucleotide binding]; DNA binding site 1112204012736 FCD domain; Region: FCD; pfam07729 1112204012737 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1112204012738 Citrate transporter; Region: CitMHS; pfam03600 1112204012739 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1112204012740 Ligand Binding Site [chemical binding]; other site 1112204012741 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1112204012742 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1112204012743 SLBB domain; Region: SLBB; pfam10531 1112204012744 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1112204012745 ApbE family; Region: ApbE; pfam02424 1112204012746 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1112204012747 short chain dehydrogenase; Provisional; Region: PRK06197 1112204012748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204012749 NAD(P) binding site [chemical binding]; other site 1112204012750 active site 1112204012751 Cupin domain; Region: Cupin_2; pfam07883 1112204012752 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1112204012753 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1112204012754 NADP binding site [chemical binding]; other site 1112204012755 dimer interface [polypeptide binding]; other site 1112204012756 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1112204012757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1112204012758 metal binding site [ion binding]; metal-binding site 1112204012759 active site 1112204012760 I-site; other site 1112204012761 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1112204012762 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1112204012763 dimer interface [polypeptide binding]; other site 1112204012764 putative PBP binding regions; other site 1112204012765 ABC-ATPase subunit interface; other site 1112204012766 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1112204012767 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1112204012768 ABC-ATPase subunit interface; other site 1112204012769 dimer interface [polypeptide binding]; other site 1112204012770 putative PBP binding regions; other site 1112204012771 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1112204012772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1112204012773 Walker A/P-loop; other site 1112204012774 ATP binding site [chemical binding]; other site 1112204012775 Q-loop/lid; other site 1112204012776 ABC transporter signature motif; other site 1112204012777 Walker B; other site 1112204012778 D-loop; other site 1112204012779 H-loop/switch region; other site 1112204012780 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1112204012781 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1112204012782 intersubunit interface [polypeptide binding]; other site 1112204012783 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1112204012784 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1112204012785 putative NAD(P) binding site [chemical binding]; other site 1112204012786 putative substrate binding site [chemical binding]; other site 1112204012787 catalytic Zn binding site [ion binding]; other site 1112204012788 structural Zn binding site [ion binding]; other site 1112204012789 dimer interface [polypeptide binding]; other site 1112204012790 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1112204012791 catalytic residues [active] 1112204012792 dimer interface [polypeptide binding]; other site 1112204012793 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1112204012794 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1112204012795 putative dimer interface [polypeptide binding]; other site 1112204012796 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1112204012797 GAF domain; Region: GAF_2; pfam13185 1112204012798 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1112204012799 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1112204012800 putative active site [active] 1112204012801 putative metal binding site [ion binding]; other site 1112204012802 amino acid transporter; Region: 2A0306; TIGR00909 1112204012803 Spore germination protein; Region: Spore_permease; cl17796 1112204012804 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1112204012805 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1112204012806 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1112204012807 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1112204012808 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1112204012809 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1112204012810 active site 1112204012811 dimer interface [polypeptide binding]; other site 1112204012812 non-prolyl cis peptide bond; other site 1112204012813 insertion regions; other site 1112204012814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1112204012815 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1112204012816 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1112204012817 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1112204012818 active site residue [active] 1112204012819 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1112204012820 active site residue [active] 1112204012821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204012822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204012823 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204012824 Cytochrome P450; Region: p450; cl12078 1112204012825 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204012826 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1112204012827 FMN-binding pocket [chemical binding]; other site 1112204012828 flavin binding motif; other site 1112204012829 phosphate binding motif [ion binding]; other site 1112204012830 beta-alpha-beta structure motif; other site 1112204012831 NAD binding pocket [chemical binding]; other site 1112204012832 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204012833 catalytic loop [active] 1112204012834 iron binding site [ion binding]; other site 1112204012835 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1112204012836 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1112204012837 FAD binding pocket [chemical binding]; other site 1112204012838 FAD binding motif [chemical binding]; other site 1112204012839 phosphate binding motif [ion binding]; other site 1112204012840 NAD binding pocket [chemical binding]; other site 1112204012841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204012842 NAD(P) binding site [chemical binding]; other site 1112204012843 active site 1112204012844 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1112204012845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204012846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204012847 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1112204012848 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1112204012849 Walker A/P-loop; other site 1112204012850 ATP binding site [chemical binding]; other site 1112204012851 Q-loop/lid; other site 1112204012852 ABC transporter signature motif; other site 1112204012853 Walker B; other site 1112204012854 D-loop; other site 1112204012855 H-loop/switch region; other site 1112204012856 TOBE domain; Region: TOBE_2; pfam08402 1112204012857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1112204012858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204012859 dimer interface [polypeptide binding]; other site 1112204012860 conserved gate region; other site 1112204012861 putative PBP binding loops; other site 1112204012862 ABC-ATPase subunit interface; other site 1112204012863 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1112204012864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204012865 dimer interface [polypeptide binding]; other site 1112204012866 conserved gate region; other site 1112204012867 putative PBP binding loops; other site 1112204012868 ABC-ATPase subunit interface; other site 1112204012869 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1112204012870 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1112204012871 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1112204012872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204012873 DNA binding residues [nucleotide binding] 1112204012874 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1112204012875 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1112204012876 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1112204012877 inhibitor binding site; inhibition site 1112204012878 catalytic Zn binding site [ion binding]; other site 1112204012879 structural Zn binding site [ion binding]; other site 1112204012880 NADP binding site [chemical binding]; other site 1112204012881 tetramer interface [polypeptide binding]; other site 1112204012882 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1112204012883 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1112204012884 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1112204012885 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1112204012886 nucleotide binding site [chemical binding]; other site 1112204012887 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204012888 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204012889 active site 1112204012890 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204012891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204012892 DNA-binding site [nucleotide binding]; DNA binding site 1112204012893 FCD domain; Region: FCD; pfam07729 1112204012894 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204012895 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204012896 active site 1112204012897 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204012898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204012899 NAD(P) binding site [chemical binding]; other site 1112204012900 active site 1112204012901 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1112204012902 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204012903 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1112204012904 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204012905 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1112204012906 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1112204012907 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1112204012908 NAD(P) binding pocket [chemical binding]; other site 1112204012909 amino acid transporter; Region: 2A0306; TIGR00909 1112204012910 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1112204012911 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1112204012912 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1112204012913 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204012914 Cytochrome P450; Region: p450; cl12078 1112204012915 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204012916 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1112204012917 FMN-binding pocket [chemical binding]; other site 1112204012918 flavin binding motif; other site 1112204012919 phosphate binding motif [ion binding]; other site 1112204012920 beta-alpha-beta structure motif; other site 1112204012921 NAD binding pocket [chemical binding]; other site 1112204012922 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204012923 catalytic loop [active] 1112204012924 iron binding site [ion binding]; other site 1112204012925 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204012926 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204012927 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204012928 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1112204012929 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204012930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204012931 active site 1112204012932 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 1112204012933 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1112204012934 dimer interface [polypeptide binding]; other site 1112204012935 active site 1112204012936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204012937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204012938 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1112204012939 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204012940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204012941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204012942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204012943 MarR family; Region: MarR_2; pfam12802 1112204012944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204012945 putative substrate translocation pore; other site 1112204012946 TspO/MBR family; Region: TspO_MBR; pfam03073 1112204012947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1112204012948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1112204012949 metal binding site [ion binding]; metal-binding site 1112204012950 active site 1112204012951 I-site; other site 1112204012952 Site-specific recombinase; Region: SpecificRecomb; cl15411 1112204012953 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1112204012954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1112204012955 metal binding site [ion binding]; metal-binding site 1112204012956 active site 1112204012957 I-site; other site 1112204012958 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1112204012959 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1112204012960 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1112204012961 active site 1112204012962 catalytic tetrad [active] 1112204012963 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204012964 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1112204012965 active site 1112204012966 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1112204012967 MgtC family; Region: MgtC; pfam02308 1112204012968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204012969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204012970 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204012971 active site 1112204012972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204012973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204012974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204012975 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1112204012976 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1112204012977 active site 1112204012978 enoyl-CoA hydratase; Provisional; Region: PRK06494 1112204012979 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204012980 substrate binding site [chemical binding]; other site 1112204012981 oxyanion hole (OAH) forming residues; other site 1112204012982 trimer interface [polypeptide binding]; other site 1112204012983 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204012984 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1112204012985 Domain of unknown function (DUF385); Region: DUF385; cl04387 1112204012986 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204012987 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204012988 active site 1112204012989 ATP binding site [chemical binding]; other site 1112204012990 substrate binding site [chemical binding]; other site 1112204012991 activation loop (A-loop); other site 1112204012992 L-asparagine permease; Provisional; Region: PRK15049 1112204012993 Amidohydrolase; Region: Amidohydro_2; pfam04909 1112204012994 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1112204012995 heme-binding site [chemical binding]; other site 1112204012996 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1112204012997 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1112204012998 FAD binding pocket [chemical binding]; other site 1112204012999 FAD binding motif [chemical binding]; other site 1112204013000 phosphate binding motif [ion binding]; other site 1112204013001 beta-alpha-beta structure motif; other site 1112204013002 NAD binding pocket [chemical binding]; other site 1112204013003 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1112204013004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204013005 DNA binding residues [nucleotide binding] 1112204013006 putative dimer interface [polypeptide binding]; other site 1112204013007 chaperone protein DnaJ; Provisional; Region: PRK14279 1112204013008 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1112204013009 HSP70 interaction site [polypeptide binding]; other site 1112204013010 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1112204013011 Zn binding sites [ion binding]; other site 1112204013012 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1112204013013 dimer interface [polypeptide binding]; other site 1112204013014 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1112204013015 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1112204013016 dimer interface [polypeptide binding]; other site 1112204013017 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1112204013018 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1112204013019 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1112204013020 nucleotide binding site [chemical binding]; other site 1112204013021 NEF interaction site [polypeptide binding]; other site 1112204013022 SBD interface [polypeptide binding]; other site 1112204013023 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1112204013024 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1112204013025 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204013026 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 1112204013027 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1112204013028 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204013029 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1112204013030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204013031 Walker A motif; other site 1112204013032 ATP binding site [chemical binding]; other site 1112204013033 Walker B motif; other site 1112204013034 arginine finger; other site 1112204013035 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1112204013036 Putative esterase; Region: Esterase; pfam00756 1112204013037 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1112204013038 haloalkane dehalogenase; Provisional; Region: PRK03204 1112204013039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013041 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1112204013042 Predicted membrane protein [Function unknown]; Region: COG2259 1112204013043 Iron permease FTR1 family; Region: FTR1; cl00475 1112204013044 Imelysin; Region: Peptidase_M75; pfam09375 1112204013045 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1112204013046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1112204013047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204013048 ATP binding site [chemical binding]; other site 1112204013049 Mg2+ binding site [ion binding]; other site 1112204013050 G-X-G motif; other site 1112204013051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204013052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204013053 active site 1112204013054 phosphorylation site [posttranslational modification] 1112204013055 intermolecular recognition site; other site 1112204013056 dimerization interface [polypeptide binding]; other site 1112204013057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204013058 DNA binding residues [nucleotide binding] 1112204013059 dimerization interface [polypeptide binding]; other site 1112204013060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204013061 Serine hydrolase; Region: Ser_hydrolase; cl17834 1112204013062 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204013063 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204013064 active site 1112204013065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013066 putative substrate translocation pore; other site 1112204013067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013068 Predicted membrane protein [Function unknown]; Region: COG4270 1112204013069 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1112204013070 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204013071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204013072 putative Zn2+ binding site [ion binding]; other site 1112204013073 putative DNA binding site [nucleotide binding]; other site 1112204013074 Domain of unknown function (DUF427); Region: DUF427; cl00998 1112204013075 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1112204013076 hydrophobic ligand binding site; other site 1112204013077 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1112204013078 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1112204013079 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1112204013080 Competence-damaged protein; Region: CinA; pfam02464 1112204013081 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1112204013082 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1112204013083 SnoaL-like domain; Region: SnoaL_4; pfam13577 1112204013084 SnoaL-like domain; Region: SnoaL_3; pfam13474 1112204013085 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1112204013086 GAF domain; Region: GAF; pfam01590 1112204013087 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1112204013088 PAS fold; Region: PAS_3; pfam08447 1112204013089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1112204013090 putative active site [active] 1112204013091 heme pocket [chemical binding]; other site 1112204013092 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1112204013093 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1112204013094 hydrophobic ligand binding site; other site 1112204013095 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1112204013096 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1112204013097 NAD binding site [chemical binding]; other site 1112204013098 catalytic Zn binding site [ion binding]; other site 1112204013099 structural Zn binding site [ion binding]; other site 1112204013100 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1112204013101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204013102 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1112204013103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204013104 DNA binding residues [nucleotide binding] 1112204013105 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1112204013106 anti sigma factor interaction site; other site 1112204013107 regulatory phosphorylation site [posttranslational modification]; other site 1112204013108 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1112204013109 Nitroreductase family; Region: Nitroreductase; pfam00881 1112204013110 FMN binding site [chemical binding]; other site 1112204013111 dimer interface [polypeptide binding]; other site 1112204013112 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1112204013113 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1112204013114 tetramer interface [polypeptide binding]; other site 1112204013115 heme binding pocket [chemical binding]; other site 1112204013116 NADPH binding site [chemical binding]; other site 1112204013117 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204013118 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204013119 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204013120 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204013121 ethanolamine permease; Region: 2A0305; TIGR00908 1112204013122 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1112204013123 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1112204013124 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1112204013125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1112204013126 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1112204013127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013129 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1112204013130 intersubunit interface [polypeptide binding]; other site 1112204013131 active site 1112204013132 Zn2+ binding site [ion binding]; other site 1112204013133 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1112204013134 active site 1112204013135 substrate binding site [chemical binding]; other site 1112204013136 ATP binding site [chemical binding]; other site 1112204013137 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1112204013138 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1112204013139 catalytic residues [active] 1112204013140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1112204013141 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1112204013142 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1112204013143 [2Fe-2S] cluster binding site [ion binding]; other site 1112204013144 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1112204013145 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1112204013146 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1112204013147 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1112204013148 short chain dehydrogenase; Provisional; Region: PRK06197 1112204013149 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1112204013150 putative NAD(P) binding site [chemical binding]; other site 1112204013151 active site 1112204013152 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204013153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204013154 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1112204013155 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1112204013156 active site 1112204013157 catalytic triad [active] 1112204013158 oxyanion hole [active] 1112204013159 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1112204013160 putative active site [active] 1112204013161 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1112204013162 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1112204013163 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1112204013164 4Fe-4S binding domain; Region: Fer4; cl02805 1112204013165 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1112204013166 Cysteine-rich domain; Region: CCG; pfam02754 1112204013167 Cysteine-rich domain; Region: CCG; pfam02754 1112204013168 aminotransferase AlaT; Validated; Region: PRK09265 1112204013169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204013170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204013171 homodimer interface [polypeptide binding]; other site 1112204013172 catalytic residue [active] 1112204013173 short chain dehydrogenase; Validated; Region: PRK05855 1112204013174 classical (c) SDRs; Region: SDR_c; cd05233 1112204013175 NAD(P) binding site [chemical binding]; other site 1112204013176 active site 1112204013177 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1112204013178 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1112204013179 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1112204013180 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1112204013181 FMN-binding pocket [chemical binding]; other site 1112204013182 flavin binding motif; other site 1112204013183 phosphate binding motif [ion binding]; other site 1112204013184 beta-alpha-beta structure motif; other site 1112204013185 NAD binding pocket [chemical binding]; other site 1112204013186 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204013187 catalytic loop [active] 1112204013188 iron binding site [ion binding]; other site 1112204013189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013190 putative substrate translocation pore; other site 1112204013191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013194 WHG domain; Region: WHG; pfam13305 1112204013195 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1112204013196 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204013197 DNA binding residues [nucleotide binding] 1112204013198 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1112204013199 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1112204013200 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1112204013201 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1112204013202 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1112204013203 trimer interface [polypeptide binding]; other site 1112204013204 active site 1112204013205 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1112204013206 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1112204013207 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1112204013208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013209 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1112204013210 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1112204013211 putative NAD(P) binding site [chemical binding]; other site 1112204013212 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1112204013213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013215 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1112204013216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204013217 NAD(P) binding site [chemical binding]; other site 1112204013218 active site 1112204013219 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1112204013220 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204013221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1112204013222 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1112204013223 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1112204013224 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 1112204013225 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1112204013226 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1112204013227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204013228 MarR family; Region: MarR; pfam01047 1112204013229 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1112204013230 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1112204013231 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1112204013232 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1112204013233 YceI-like domain; Region: YceI; smart00867 1112204013234 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1112204013235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013236 putative substrate translocation pore; other site 1112204013237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013238 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1112204013239 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1112204013240 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1112204013241 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1112204013242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204013243 NAD(P) binding site [chemical binding]; other site 1112204013244 active site 1112204013245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013246 metabolite-proton symporter; Region: 2A0106; TIGR00883 1112204013247 putative substrate translocation pore; other site 1112204013248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204013249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204013250 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1112204013251 dimerization interface [polypeptide binding]; other site 1112204013252 RibD C-terminal domain; Region: RibD_C; cl17279 1112204013253 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204013254 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1112204013255 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1112204013256 PA/protease or protease-like domain interface [polypeptide binding]; other site 1112204013257 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1112204013258 Peptidase family M28; Region: Peptidase_M28; pfam04389 1112204013259 active site 1112204013260 metal binding site [ion binding]; metal-binding site 1112204013261 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1112204013262 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204013263 AAA domain; Region: AAA_22; pfam13401 1112204013264 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1112204013265 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1112204013266 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1112204013267 oxidase reductase; Provisional; Region: PTZ00273 1112204013268 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204013269 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204013270 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1112204013271 nucleoside/Zn binding site; other site 1112204013272 dimer interface [polypeptide binding]; other site 1112204013273 catalytic motif [active] 1112204013274 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1112204013275 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204013276 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204013277 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204013278 active site 1112204013279 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1112204013280 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1112204013281 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1112204013282 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1112204013283 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1112204013284 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1112204013285 Cysteine-rich domain; Region: CCG; pfam02754 1112204013286 Cysteine-rich domain; Region: CCG; pfam02754 1112204013287 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1112204013288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204013289 DNA-binding site [nucleotide binding]; DNA binding site 1112204013290 FCD domain; Region: FCD; pfam07729 1112204013291 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1112204013292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013293 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1112204013294 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1112204013295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013296 putative substrate translocation pore; other site 1112204013297 enoyl-CoA hydratase; Provisional; Region: PRK05862 1112204013298 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204013299 substrate binding site [chemical binding]; other site 1112204013300 oxyanion hole (OAH) forming residues; other site 1112204013301 trimer interface [polypeptide binding]; other site 1112204013302 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1112204013303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204013304 substrate binding site [chemical binding]; other site 1112204013305 oxyanion hole (OAH) forming residues; other site 1112204013306 trimer interface [polypeptide binding]; other site 1112204013307 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1112204013308 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 1112204013309 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1112204013310 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1112204013311 active site 1112204013312 catalytic triad [active] 1112204013313 dimer interface [polypeptide binding]; other site 1112204013314 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 1112204013315 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1112204013316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204013317 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 1112204013318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1112204013319 FeS/SAM binding site; other site 1112204013320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1112204013321 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 1112204013322 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 1112204013323 dimerization interface [polypeptide binding]; other site 1112204013324 putative ATP binding site [chemical binding]; other site 1112204013325 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1112204013326 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1112204013327 active site 1112204013328 catalytic triad [active] 1112204013329 dimer interface [polypeptide binding]; other site 1112204013330 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 1112204013331 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1112204013332 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1112204013333 active site 1112204013334 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1112204013335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204013336 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204013337 putative DNA binding site [nucleotide binding]; other site 1112204013338 dimerization interface [polypeptide binding]; other site 1112204013339 putative Zn2+ binding site [ion binding]; other site 1112204013340 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1112204013341 putative dimerization interface [polypeptide binding]; other site 1112204013342 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1112204013343 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204013344 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1112204013345 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1112204013346 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1112204013347 dimer interface [polypeptide binding]; other site 1112204013348 NADP binding site [chemical binding]; other site 1112204013349 catalytic residues [active] 1112204013350 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1112204013351 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 1112204013352 catalytic residue [active] 1112204013353 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1112204013354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204013355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1112204013356 dimerization interface [polypeptide binding]; other site 1112204013357 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1112204013358 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1112204013359 active site 1112204013360 tetramer interface [polypeptide binding]; other site 1112204013361 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1112204013362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013363 putative substrate translocation pore; other site 1112204013364 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204013365 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204013366 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1112204013367 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1112204013368 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1112204013369 catalytic triad [active] 1112204013370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1112204013371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1112204013372 Coenzyme A binding pocket [chemical binding]; other site 1112204013373 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1112204013374 Fe-S cluster binding site [ion binding]; other site 1112204013375 DNA binding site [nucleotide binding] 1112204013376 active site 1112204013377 hypothetical protein; Provisional; Region: PRK06547 1112204013378 recombination protein RecR; Reviewed; Region: recR; PRK00076 1112204013379 RecR protein; Region: RecR; pfam02132 1112204013380 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1112204013381 putative active site [active] 1112204013382 putative metal-binding site [ion binding]; other site 1112204013383 tetramer interface [polypeptide binding]; other site 1112204013384 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1112204013385 Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520 1112204013386 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1112204013387 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1112204013388 active site 1112204013389 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1112204013390 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1112204013391 FAD binding domain; Region: FAD_binding_4; pfam01565 1112204013392 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1112204013393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204013394 S-adenosylmethionine binding site [chemical binding]; other site 1112204013395 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1112204013396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204013397 Walker A motif; other site 1112204013398 ATP binding site [chemical binding]; other site 1112204013399 Walker B motif; other site 1112204013400 arginine finger; other site 1112204013401 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1112204013402 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204013403 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204013404 acyl-activating enzyme (AAE) consensus motif; other site 1112204013405 acyl-activating enzyme (AAE) consensus motif; other site 1112204013406 putative AMP binding site [chemical binding]; other site 1112204013407 putative active site [active] 1112204013408 putative CoA binding site [chemical binding]; other site 1112204013409 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1112204013410 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1112204013411 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204013412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204013413 homodimer interface [polypeptide binding]; other site 1112204013414 catalytic residue [active] 1112204013415 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1112204013416 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1112204013417 active site 1112204013418 catalytic triad [active] 1112204013419 oxyanion hole [active] 1112204013420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1112204013421 Zn2+ binding site [ion binding]; other site 1112204013422 Mg2+ binding site [ion binding]; other site 1112204013423 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1112204013424 NmrA-like family; Region: NmrA; pfam05368 1112204013425 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1112204013426 NADP binding site [chemical binding]; other site 1112204013427 active site 1112204013428 regulatory binding site [polypeptide binding]; other site 1112204013429 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1112204013430 nucleotide binding site [chemical binding]; other site 1112204013431 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1112204013432 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1112204013433 active site 1112204013434 DNA binding site [nucleotide binding] 1112204013435 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1112204013436 DNA binding site [nucleotide binding] 1112204013437 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1112204013438 HIGH motif; other site 1112204013439 active site 1112204013440 KMSKS motif; other site 1112204013441 Domain of unknown function DUF21; Region: DUF21; pfam01595 1112204013442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1112204013443 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1112204013444 Domain of unknown function DUF21; Region: DUF21; pfam01595 1112204013445 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1112204013446 Transporter associated domain; Region: CorC_HlyC; pfam03471 1112204013447 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1112204013448 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1112204013449 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1112204013450 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204013451 DNA binding residues [nucleotide binding] 1112204013452 dimer interface [polypeptide binding]; other site 1112204013453 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1112204013454 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1112204013455 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1112204013456 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1112204013457 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1112204013458 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1112204013459 PYR/PP interface [polypeptide binding]; other site 1112204013460 dimer interface [polypeptide binding]; other site 1112204013461 TPP binding site [chemical binding]; other site 1112204013462 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1112204013463 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1112204013464 TPP-binding site [chemical binding]; other site 1112204013465 dimer interface [polypeptide binding]; other site 1112204013466 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1112204013467 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1112204013468 Bacterial transcriptional regulator; Region: IclR; pfam01614 1112204013469 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1112204013470 Na binding site [ion binding]; other site 1112204013471 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1112204013472 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 1112204013473 NAD(P) binding site [chemical binding]; other site 1112204013474 catalytic residues [active] 1112204013475 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1112204013476 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1112204013477 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1112204013478 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1112204013479 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1112204013480 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1112204013481 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1112204013482 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1112204013483 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1112204013484 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1112204013485 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1112204013486 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1112204013487 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1112204013488 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1112204013489 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1112204013490 putative dimer interface [polypeptide binding]; other site 1112204013491 [2Fe-2S] cluster binding site [ion binding]; other site 1112204013492 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1112204013493 SLBB domain; Region: SLBB; pfam10531 1112204013494 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1112204013495 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1112204013496 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1112204013497 catalytic loop [active] 1112204013498 iron binding site [ion binding]; other site 1112204013499 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1112204013500 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1112204013501 molybdopterin cofactor binding site; other site 1112204013502 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1112204013503 molybdopterin cofactor binding site; other site 1112204013504 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1112204013505 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1112204013506 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1112204013507 4Fe-4S binding domain; Region: Fer4; pfam00037 1112204013508 4Fe-4S binding domain; Region: Fer4; pfam00037 1112204013509 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1112204013510 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1112204013511 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1112204013512 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1112204013513 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1112204013514 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1112204013515 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1112204013516 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1112204013517 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1112204013518 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1112204013519 CsbD-like; Region: CsbD; cl17424 1112204013520 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1112204013521 nucleoside/Zn binding site; other site 1112204013522 dimer interface [polypeptide binding]; other site 1112204013523 catalytic motif [active] 1112204013524 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1112204013525 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1112204013526 prephenate dehydrogenase; Validated; Region: PRK08507 1112204013527 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1112204013528 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1112204013529 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1112204013530 amphipathic channel; other site 1112204013531 Asn-Pro-Ala signature motifs; other site 1112204013532 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1112204013533 DNA protecting protein DprA; Region: dprA; TIGR00732 1112204013534 HNH endonuclease; Region: HNH_3; pfam13392 1112204013535 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1112204013536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204013537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204013538 homodimer interface [polypeptide binding]; other site 1112204013539 catalytic residue [active] 1112204013540 Putative esterase; Region: Esterase; pfam00756 1112204013541 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1112204013542 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1112204013543 active site 1112204013544 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1112204013545 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1112204013546 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1112204013547 oligomer interface [polypeptide binding]; other site 1112204013548 metal binding site [ion binding]; metal-binding site 1112204013549 metal binding site [ion binding]; metal-binding site 1112204013550 putative Cl binding site [ion binding]; other site 1112204013551 aspartate ring; other site 1112204013552 basic sphincter; other site 1112204013553 hydrophobic gate; other site 1112204013554 periplasmic entrance; other site 1112204013555 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1112204013556 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1112204013557 putative active site [active] 1112204013558 putative NTP binding site [chemical binding]; other site 1112204013559 putative nucleic acid binding site [nucleotide binding]; other site 1112204013560 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204013561 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204013562 active site 1112204013563 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1112204013564 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1112204013565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204013566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013568 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1112204013569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204013570 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1112204013571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204013572 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1112204013573 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1112204013574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204013575 DNA-binding site [nucleotide binding]; DNA binding site 1112204013576 FCD domain; Region: FCD; pfam07729 1112204013577 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204013578 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204013579 mce related protein; Region: MCE; pfam02470 1112204013580 mce related protein; Region: MCE; pfam02470 1112204013581 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204013582 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204013583 mce related protein; Region: MCE; pfam02470 1112204013584 mce related protein; Region: MCE; pfam02470 1112204013585 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1112204013586 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1112204013587 mce related protein; Region: MCE; pfam02470 1112204013588 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1112204013589 mce related protein; Region: MCE; pfam02470 1112204013590 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1112204013591 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1112204013592 Permease; Region: Permease; pfam02405 1112204013593 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1112204013594 Permease; Region: Permease; pfam02405 1112204013595 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1112204013596 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1112204013597 substrate binding site [chemical binding]; other site 1112204013598 dimer interface [polypeptide binding]; other site 1112204013599 ATP binding site [chemical binding]; other site 1112204013600 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1112204013601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204013602 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1112204013603 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1112204013604 proposed catalytic triad [active] 1112204013605 conserved cys residue [active] 1112204013606 Patatin-like phospholipase; Region: Patatin; pfam01734 1112204013607 SnoaL-like domain; Region: SnoaL_2; pfam12680 1112204013608 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1112204013609 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1112204013610 inhibitor-cofactor binding pocket; inhibition site 1112204013611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204013612 catalytic residue [active] 1112204013613 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1112204013614 Predicted membrane protein [Function unknown]; Region: COG1297 1112204013615 putative oligopeptide transporter, OPT family; Region: TIGR00733 1112204013616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013618 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1112204013619 putative active site [active] 1112204013620 putative substrate binding site [chemical binding]; other site 1112204013621 ATP binding site [chemical binding]; other site 1112204013622 Phosphotransferase enzyme family; Region: APH; pfam01636 1112204013623 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204013624 active site 1112204013625 Histidine kinase; Region: HisKA_3; pfam07730 1112204013626 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1112204013627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1112204013628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204013629 active site 1112204013630 phosphorylation site [posttranslational modification] 1112204013631 intermolecular recognition site; other site 1112204013632 dimerization interface [polypeptide binding]; other site 1112204013633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1112204013634 DNA binding residues [nucleotide binding] 1112204013635 dimerization interface [polypeptide binding]; other site 1112204013636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1112204013637 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1112204013638 Walker A/P-loop; other site 1112204013639 ATP binding site [chemical binding]; other site 1112204013640 Q-loop/lid; other site 1112204013641 ABC transporter signature motif; other site 1112204013642 Walker B; other site 1112204013643 D-loop; other site 1112204013644 H-loop/switch region; other site 1112204013645 FtsX-like permease family; Region: FtsX; pfam02687 1112204013646 FtsX-like permease family; Region: FtsX; pfam02687 1112204013647 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1112204013648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204013649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204013650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204013651 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1112204013652 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1112204013653 substrate binding pocket [chemical binding]; other site 1112204013654 chain length determination region; other site 1112204013655 substrate-Mg2+ binding site; other site 1112204013656 catalytic residues [active] 1112204013657 aspartate-rich region 1; other site 1112204013658 active site lid residues [active] 1112204013659 aspartate-rich region 2; other site 1112204013660 Protein of unknown function (DUF422); Region: DUF422; cl00991 1112204013661 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1112204013662 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1112204013663 active site 1112204013664 phytoene desaturase; Region: crtI_fam; TIGR02734 1112204013665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204013666 phytoene desaturase; Region: crtI_fam; TIGR02734 1112204013667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204013668 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1112204013669 active site lid residues [active] 1112204013670 substrate binding pocket [chemical binding]; other site 1112204013671 catalytic residues [active] 1112204013672 substrate-Mg2+ binding site; other site 1112204013673 aspartate-rich region 1; other site 1112204013674 aspartate-rich region 2; other site 1112204013675 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1112204013676 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1112204013677 active site 1112204013678 metal binding site [ion binding]; metal-binding site 1112204013679 nudix motif; other site 1112204013680 Predicted membrane protein [Function unknown]; Region: COG4425 1112204013681 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1112204013682 CAAX protease self-immunity; Region: Abi; pfam02517 1112204013683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013685 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204013686 competence damage-inducible protein A; Provisional; Region: PRK00549 1112204013687 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1112204013688 putative MPT binding site; other site 1112204013689 Competence-damaged protein; Region: CinA; pfam02464 1112204013690 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1112204013691 GIY-YIG motif/motif A; other site 1112204013692 putative active site [active] 1112204013693 putative metal binding site [ion binding]; other site 1112204013694 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1112204013695 Nitronate monooxygenase; Region: NMO; pfam03060 1112204013696 FMN binding site [chemical binding]; other site 1112204013697 substrate binding site [chemical binding]; other site 1112204013698 putative catalytic residue [active] 1112204013699 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1112204013700 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1112204013701 conserved cys residue [active] 1112204013702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1112204013703 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1112204013704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1112204013705 DNA-binding site [nucleotide binding]; DNA binding site 1112204013706 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1112204013707 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1112204013708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013709 putative substrate translocation pore; other site 1112204013710 Part of AAA domain; Region: AAA_19; pfam13245 1112204013711 Family description; Region: UvrD_C_2; pfam13538 1112204013712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204013713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204013714 active site 1112204013715 Predicted transcriptional regulators [Transcription]; Region: COG1733 1112204013716 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1112204013717 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1112204013718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013719 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204013720 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1112204013721 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204013722 short chain dehydrogenase; Provisional; Region: PRK07825 1112204013723 classical (c) SDRs; Region: SDR_c; cd05233 1112204013724 NAD(P) binding site [chemical binding]; other site 1112204013725 active site 1112204013726 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204013727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1112204013728 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204013729 enoyl-CoA hydratase; Provisional; Region: PRK09245 1112204013730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204013731 substrate binding site [chemical binding]; other site 1112204013732 oxyanion hole (OAH) forming residues; other site 1112204013733 trimer interface [polypeptide binding]; other site 1112204013734 MarR family; Region: MarR_2; pfam12802 1112204013735 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204013736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204013737 NAD(P) binding site [chemical binding]; other site 1112204013738 active site 1112204013739 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1112204013740 active site 1112204013741 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1112204013742 putative active site [active] 1112204013743 putative catalytic site [active] 1112204013744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1112204013745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1112204013746 active site 1112204013747 ATP binding site [chemical binding]; other site 1112204013748 substrate binding site [chemical binding]; other site 1112204013749 activation loop (A-loop); other site 1112204013750 AAA ATPase domain; Region: AAA_16; pfam13191 1112204013751 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1112204013752 Walker A motif; other site 1112204013753 ATP binding site [chemical binding]; other site 1112204013754 Walker B motif; other site 1112204013755 Short C-terminal domain; Region: SHOCT; pfam09851 1112204013756 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1112204013757 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1112204013758 HD domain; Region: HD; pfam01966 1112204013759 Zn2+ binding site [ion binding]; other site 1112204013760 Mg2+ binding site [ion binding]; other site 1112204013761 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204013762 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1112204013763 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1112204013764 yiaA/B two helix domain; Region: YiaAB; cl01759 1112204013765 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1112204013766 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1112204013767 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1112204013768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204013769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1112204013770 dimerization interface [polypeptide binding]; other site 1112204013771 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1112204013772 EamA-like transporter family; Region: EamA; pfam00892 1112204013773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1112204013774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1112204013775 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1112204013776 putative dimerization interface [polypeptide binding]; other site 1112204013777 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1112204013778 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1112204013779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204013780 NAD(P) binding site [chemical binding]; other site 1112204013781 active site 1112204013782 Helix-turn-helix domain; Region: HTH_31; pfam13560 1112204013783 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1112204013784 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1112204013785 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1112204013786 amino acid transporter; Region: 2A0306; TIGR00909 1112204013787 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1112204013788 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1112204013789 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1112204013790 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1112204013791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1112204013792 AAA domain; Region: AAA_33; pfam13671 1112204013793 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1112204013794 Tubby C 2; Region: Tub_2; cl02043 1112204013795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013798 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204013799 putative substrate translocation pore; other site 1112204013800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013801 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1112204013802 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1112204013803 NAD binding site [chemical binding]; other site 1112204013804 substrate binding site [chemical binding]; other site 1112204013805 catalytic Zn binding site [ion binding]; other site 1112204013806 structural Zn binding site [ion binding]; other site 1112204013807 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1112204013808 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1112204013809 Walker A/P-loop; other site 1112204013810 ATP binding site [chemical binding]; other site 1112204013811 Q-loop/lid; other site 1112204013812 ABC transporter signature motif; other site 1112204013813 Walker B; other site 1112204013814 D-loop; other site 1112204013815 H-loop/switch region; other site 1112204013816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204013817 dimer interface [polypeptide binding]; other site 1112204013818 conserved gate region; other site 1112204013819 ABC-ATPase subunit interface; other site 1112204013820 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1112204013821 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204013822 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1112204013823 active site 1112204013824 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1112204013825 MMPL family; Region: MMPL; pfam03176 1112204013826 MMPL family; Region: MMPL; pfam03176 1112204013827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204013830 NAD(P) binding site [chemical binding]; other site 1112204013831 acyl-CoA synthetase; Validated; Region: PRK06188 1112204013832 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204013833 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204013834 acyl-activating enzyme (AAE) consensus motif; other site 1112204013835 putative AMP binding site [chemical binding]; other site 1112204013836 putative active site [active] 1112204013837 putative CoA binding site [chemical binding]; other site 1112204013838 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1112204013839 classical (c) SDRs; Region: SDR_c; cd05233 1112204013840 NAD(P) binding site [chemical binding]; other site 1112204013841 active site 1112204013842 hypothetical protein; Provisional; Region: PRK08244 1112204013843 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1112204013844 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1112204013845 Cytochrome P450; Region: p450; cl12078 1112204013846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204013847 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1112204013848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1112204013849 motif II; other site 1112204013850 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1112204013851 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1112204013852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1112204013853 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204013854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1112204013855 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204013856 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1112204013857 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1112204013858 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1112204013859 Walker A motif; other site 1112204013860 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 1112204013861 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1112204013862 Walker B motif; other site 1112204013863 DNA binding loops [nucleotide binding] 1112204013864 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1112204013865 protein-splicing catalytic site; other site 1112204013866 thioester formation/cholesterol transfer; other site 1112204013867 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1112204013868 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1112204013869 protein-splicing catalytic site; other site 1112204013870 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1112204013871 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1112204013872 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1112204013873 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1112204013874 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1112204013875 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1112204013876 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1112204013877 dimer interface [polypeptide binding]; other site 1112204013878 ssDNA binding site [nucleotide binding]; other site 1112204013879 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1112204013880 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1112204013881 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1112204013882 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204013883 active site 1112204013884 Predicted integral membrane protein [Function unknown]; Region: COG5650 1112204013885 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1112204013886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1112204013887 Predicted integral membrane protein [Function unknown]; Region: COG5650 1112204013888 Transglycosylase; Region: Transgly; pfam00912 1112204013889 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1112204013890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1112204013891 Predicted transcriptional regulators [Transcription]; Region: COG1695 1112204013892 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1112204013893 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1112204013894 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1112204013895 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1112204013896 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1112204013897 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1112204013898 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1112204013899 putative NAD(P) binding site [chemical binding]; other site 1112204013900 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1112204013901 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204013902 CoA binding site [chemical binding]; other site 1112204013903 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1112204013904 ATP binding site [chemical binding]; other site 1112204013905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1112204013906 phosphorylation site [posttranslational modification] 1112204013907 intermolecular recognition site; other site 1112204013908 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1112204013909 DNA binding residues [nucleotide binding] 1112204013910 acyl-CoA synthetase; Validated; Region: PRK07787 1112204013911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1112204013912 acyl-activating enzyme (AAE) consensus motif; other site 1112204013913 AMP binding site [chemical binding]; other site 1112204013914 active site 1112204013915 CoA binding site [chemical binding]; other site 1112204013916 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1112204013917 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1112204013918 putative metal binding site [ion binding]; other site 1112204013919 hypothetical protein; Provisional; Region: PRK14013 1112204013920 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1112204013921 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1112204013922 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1112204013923 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1112204013924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204013925 active site 1112204013926 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1112204013927 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1112204013928 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1112204013929 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1112204013930 putative metal binding site [ion binding]; other site 1112204013931 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1112204013932 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1112204013933 putative metal binding site [ion binding]; other site 1112204013934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204013935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204013936 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1112204013937 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1112204013938 acyl-activating enzyme (AAE) consensus motif; other site 1112204013939 putative AMP binding site [chemical binding]; other site 1112204013940 putative active site [active] 1112204013941 putative CoA binding site [chemical binding]; other site 1112204013942 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204013943 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1112204013944 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1112204013945 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1112204013946 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1112204013947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204013948 active site 1112204013949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204013950 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1112204013951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204013952 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1112204013953 Protein of unknown function (DUF429); Region: DUF429; cl12046 1112204013954 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 1112204013955 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1112204013956 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204013957 catalytic residue [active] 1112204013958 putative phosphoketolase; Provisional; Region: PRK05261 1112204013959 XFP N-terminal domain; Region: XFP_N; pfam09364 1112204013960 XFP C-terminal domain; Region: XFP_C; pfam09363 1112204013961 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1112204013962 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204013963 DNA binding residues [nucleotide binding] 1112204013964 putative dimer interface [polypeptide binding]; other site 1112204013965 HEAT repeats; Region: HEAT_2; pfam13646 1112204013966 HEAT repeats; Region: HEAT_2; pfam13646 1112204013967 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1112204013968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1112204013969 active site 1112204013970 phosphorylation site [posttranslational modification] 1112204013971 intermolecular recognition site; other site 1112204013972 dimerization interface [polypeptide binding]; other site 1112204013973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204013974 putative DNA binding site [nucleotide binding]; other site 1112204013975 putative Zn2+ binding site [ion binding]; other site 1112204013976 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1112204013977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204013978 ATP binding site [chemical binding]; other site 1112204013979 G-X-G motif; other site 1112204013980 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1112204013981 Citrate transporter; Region: CitMHS; pfam03600 1112204013982 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1112204013983 Citrate transporter; Region: CitMHS; pfam03600 1112204013984 DNA polymerase IV; Validated; Region: PRK03858 1112204013985 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1112204013986 active site 1112204013987 DNA binding site [nucleotide binding] 1112204013988 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1112204013989 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1112204013990 active site 1112204013991 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1112204013992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1112204013993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204013994 homodimer interface [polypeptide binding]; other site 1112204013995 catalytic residue [active] 1112204013996 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1112204013997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204013998 S-adenosylmethionine binding site [chemical binding]; other site 1112204013999 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1112204014000 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1112204014001 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1112204014002 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1112204014003 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1112204014004 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1112204014005 Walker A/P-loop; other site 1112204014006 ATP binding site [chemical binding]; other site 1112204014007 Q-loop/lid; other site 1112204014008 ABC transporter signature motif; other site 1112204014009 Walker B; other site 1112204014010 D-loop; other site 1112204014011 H-loop/switch region; other site 1112204014012 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1112204014013 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1112204014014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204014015 dimer interface [polypeptide binding]; other site 1112204014016 conserved gate region; other site 1112204014017 putative PBP binding loops; other site 1112204014018 ABC-ATPase subunit interface; other site 1112204014019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1112204014020 dimer interface [polypeptide binding]; other site 1112204014021 conserved gate region; other site 1112204014022 putative PBP binding loops; other site 1112204014023 ABC-ATPase subunit interface; other site 1112204014024 Repair protein; Region: Repair_PSII; pfam04536 1112204014025 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1112204014026 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1112204014027 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1112204014028 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1112204014029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1112204014030 non-specific DNA binding site [nucleotide binding]; other site 1112204014031 salt bridge; other site 1112204014032 sequence-specific DNA binding site [nucleotide binding]; other site 1112204014033 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1112204014034 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1112204014035 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1112204014036 oxidase reductase; Provisional; Region: PTZ00273 1112204014037 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204014038 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204014039 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1112204014040 adenosine deaminase; Provisional; Region: PRK09358 1112204014041 active site 1112204014042 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1112204014043 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1112204014044 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1112204014045 MarR family; Region: MarR; pfam01047 1112204014046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1112204014047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1112204014048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1112204014049 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 1112204014050 short chain dehydrogenase; Provisional; Region: PRK08219 1112204014051 classical (c) SDRs; Region: SDR_c; cd05233 1112204014052 NAD(P) binding site [chemical binding]; other site 1112204014053 active site 1112204014054 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1112204014055 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1112204014056 MoxR-like ATPases [General function prediction only]; Region: COG0714 1112204014057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204014058 Walker A motif; other site 1112204014059 ATP binding site [chemical binding]; other site 1112204014060 Walker B motif; other site 1112204014061 arginine finger; other site 1112204014062 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1112204014063 Protein of unknown function DUF58; Region: DUF58; pfam01882 1112204014064 PE-PPE domain; Region: PE-PPE; pfam08237 1112204014065 Integral membrane protein DUF95; Region: DUF95; pfam01944 1112204014066 RDD family; Region: RDD; pfam06271 1112204014067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1112204014068 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1112204014069 active site 1112204014070 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1112204014071 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1112204014072 NAD(P) binding site [chemical binding]; other site 1112204014073 active site 1112204014074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204014075 dimerization interface [polypeptide binding]; other site 1112204014076 putative DNA binding site [nucleotide binding]; other site 1112204014077 putative Zn2+ binding site [ion binding]; other site 1112204014078 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1112204014079 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1112204014080 active site 1112204014081 HIGH motif; other site 1112204014082 nucleotide binding site [chemical binding]; other site 1112204014083 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1112204014084 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1112204014085 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1112204014086 active site 1112204014087 KMSKS motif; other site 1112204014088 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1112204014089 tRNA binding surface [nucleotide binding]; other site 1112204014090 SdpI/YhfL protein family; Region: SdpI; pfam13630 1112204014091 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1112204014092 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1112204014093 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1112204014094 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1112204014095 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1112204014096 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1112204014097 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1112204014098 hypothetical protein; Validated; Region: PRK00228 1112204014099 H+ Antiporter protein; Region: 2A0121; TIGR00900 1112204014100 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1112204014101 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1112204014102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1112204014103 catalytic residue [active] 1112204014104 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1112204014105 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1112204014106 active site 1112204014107 NTP binding site [chemical binding]; other site 1112204014108 metal binding triad [ion binding]; metal-binding site 1112204014109 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1112204014110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1112204014111 Zn2+ binding site [ion binding]; other site 1112204014112 Mg2+ binding site [ion binding]; other site 1112204014113 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1112204014114 active site 1112204014115 Ap6A binding site [chemical binding]; other site 1112204014116 nudix motif; other site 1112204014117 metal binding site [ion binding]; metal-binding site 1112204014118 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1112204014119 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1112204014120 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1112204014121 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1112204014122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204014123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204014124 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1112204014125 Lsr2; Region: Lsr2; pfam11774 1112204014126 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1112204014127 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1112204014128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1112204014129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204014130 DNA binding residues [nucleotide binding] 1112204014131 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1112204014132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1112204014133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204014134 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1112204014135 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1112204014136 catalytic residues [active] 1112204014137 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1112204014138 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1112204014139 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1112204014140 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1112204014141 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1112204014142 active site 1112204014143 metal binding site [ion binding]; metal-binding site 1112204014144 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1112204014145 ParB-like nuclease domain; Region: ParBc; pfam02195 1112204014146 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1112204014147 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1112204014148 P-loop; other site 1112204014149 Magnesium ion binding site [ion binding]; other site 1112204014150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1112204014151 Magnesium ion binding site [ion binding]; other site 1112204014152 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1112204014153 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1112204014154 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1112204014155 G-X-X-G motif; other site 1112204014156 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1112204014157 RxxxH motif; other site 1112204014158 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1112204014159 Ribonuclease P; Region: Ribonuclease_P; cl00457 1112204014160 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1112204014161 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1112204014162 metal binding site [ion binding]; metal-binding site 1112204014163 substrate binding pocket [chemical binding]; other site 1112204014164 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1112204014165 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 1112204014166 NAD binding site [chemical binding]; other site 1112204014167 ligand binding site [chemical binding]; other site 1112204014168 catalytic site [active] 1112204014169 HTH-like domain; Region: HTH_21; pfam13276 1112204014170 Transposase; Region: HTH_Tnp_1; cl17663 1112204014171 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204014172 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204014173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1112204014174 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204014175 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1112204014176 MarR family; Region: MarR; pfam01047 1112204014177 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1112204014178 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1112204014179 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1112204014180 ApbE family; Region: ApbE; pfam02424 1112204014181 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1112204014182 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1112204014183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204014184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204014185 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1112204014186 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204014187 MULE transposase domain; Region: MULE; pfam10551 1112204014188 RES domain; Region: RES; pfam08808 1112204014189 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1112204014190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1112204014191 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1112204014192 Domain of unknown function (DUF385); Region: DUF385; cl04387 1112204014193 Lsr2; Region: Lsr2; pfam11774 1112204014194 transposase; Provisional; Region: PRK06526 1112204014195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204014196 Walker A motif; other site 1112204014197 ATP binding site [chemical binding]; other site 1112204014198 Walker B motif; other site 1112204014199 flavodoxin; Provisional; Region: PRK06242 1112204014200 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1112204014201 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1112204014202 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1112204014203 DNA binding residues [nucleotide binding] 1112204014204 OsmC-like protein; Region: OsmC; pfam02566 1112204014205 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1112204014206 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1112204014207 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1112204014208 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1112204014209 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1112204014210 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1112204014211 NAD(P) binding site [chemical binding]; other site 1112204014212 catalytic residues [active] 1112204014213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204014214 NAD(P) binding site [chemical binding]; other site 1112204014215 active site 1112204014216 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1112204014217 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204014218 substrate binding pocket [chemical binding]; other site 1112204014219 catalytic triad [active] 1112204014220 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1112204014221 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1112204014222 tetramer interface [polypeptide binding]; other site 1112204014223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204014224 catalytic residue [active] 1112204014225 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1112204014226 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1112204014227 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1112204014228 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1112204014229 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1112204014230 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1112204014231 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1112204014232 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1112204014233 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1112204014234 RNA binding site [nucleotide binding]; other site 1112204014235 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1112204014236 nudix motif; other site 1112204014237 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1112204014238 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1112204014239 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1112204014240 shikimate binding site; other site 1112204014241 NAD(P) binding site [chemical binding]; other site 1112204014242 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1112204014243 pyruvate dehydrogenase; Provisional; Region: PRK09124 1112204014244 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1112204014245 PYR/PP interface [polypeptide binding]; other site 1112204014246 tetramer interface [polypeptide binding]; other site 1112204014247 dimer interface [polypeptide binding]; other site 1112204014248 TPP binding site [chemical binding]; other site 1112204014249 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1112204014250 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1112204014251 TPP-binding site [chemical binding]; other site 1112204014252 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1112204014253 putative active site [active] 1112204014254 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1112204014255 active site 1112204014256 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1112204014257 active site 1112204014258 SUMO-1 interface [polypeptide binding]; other site 1112204014259 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1112204014260 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1112204014261 malate dehydrogenase; Provisional; Region: PRK05442 1112204014262 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1112204014263 NAD(P) binding site [chemical binding]; other site 1112204014264 LDH/MDH dimer interface [polypeptide binding]; other site 1112204014265 substrate binding site [chemical binding]; other site 1112204014266 META domain; Region: META; pfam03724 1112204014267 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 1112204014268 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1112204014269 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1112204014270 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1112204014271 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1112204014272 lipoyl attachment site [posttranslational modification]; other site 1112204014273 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1112204014274 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1112204014275 phosphopeptide binding site; other site 1112204014276 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1112204014277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204014278 DNA binding residues [nucleotide binding] 1112204014279 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1112204014280 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1112204014281 DNA binding residues [nucleotide binding] 1112204014282 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1112204014283 putative dimer interface [polypeptide binding]; other site 1112204014284 glycine dehydrogenase; Provisional; Region: PRK05367 1112204014285 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1112204014286 tetramer interface [polypeptide binding]; other site 1112204014287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204014288 catalytic residue [active] 1112204014289 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1112204014290 tetramer interface [polypeptide binding]; other site 1112204014291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1112204014292 catalytic residue [active] 1112204014293 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1112204014294 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1112204014295 active site 1112204014296 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1112204014297 Domain of unknown function DUF21; Region: DUF21; pfam01595 1112204014298 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1112204014299 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1112204014300 Domain of unknown function DUF21; Region: DUF21; pfam01595 1112204014301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1112204014302 Transporter associated domain; Region: CorC_HlyC; smart01091 1112204014303 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1112204014304 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1112204014305 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1112204014306 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1112204014307 active site 1112204014308 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1112204014309 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1112204014310 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1112204014311 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1112204014312 Predicted transcriptional regulator [Transcription]; Region: COG3682 1112204014313 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1112204014314 CoenzymeA binding site [chemical binding]; other site 1112204014315 subunit interaction site [polypeptide binding]; other site 1112204014316 PHB binding site; other site 1112204014317 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1112204014318 alpha-gamma subunit interface [polypeptide binding]; other site 1112204014319 beta-gamma subunit interface [polypeptide binding]; other site 1112204014320 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1112204014321 gamma-beta subunit interface [polypeptide binding]; other site 1112204014322 alpha-beta subunit interface [polypeptide binding]; other site 1112204014323 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1112204014324 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1112204014325 subunit interactions [polypeptide binding]; other site 1112204014326 active site 1112204014327 flap region; other site 1112204014328 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1112204014329 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1112204014330 UreD urease accessory protein; Region: UreD; cl00530 1112204014331 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1112204014332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1112204014333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1112204014334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1112204014335 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1112204014336 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1112204014337 active site 1112204014338 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1112204014339 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1112204014340 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1112204014341 Part of AAA domain; Region: AAA_19; pfam13245 1112204014342 Family description; Region: UvrD_C_2; pfam13538 1112204014343 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1112204014344 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1112204014345 AAA domain; Region: AAA_30; pfam13604 1112204014346 Family description; Region: UvrD_C_2; pfam13538 1112204014347 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1112204014348 heat shock protein 90; Provisional; Region: PRK05218 1112204014349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1112204014350 ATP binding site [chemical binding]; other site 1112204014351 Mg2+ binding site [ion binding]; other site 1112204014352 G-X-G motif; other site 1112204014353 Domain of unknown function (DUF385); Region: DUF385; cl04387 1112204014354 enoyl-CoA hydratase; Provisional; Region: PRK06142 1112204014355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1112204014356 substrate binding site [chemical binding]; other site 1112204014357 oxyanion hole (OAH) forming residues; other site 1112204014358 trimer interface [polypeptide binding]; other site 1112204014359 Helix-turn-helix domain; Region: HTH_18; pfam12833 1112204014360 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1112204014361 RibD C-terminal domain; Region: RibD_C; cl17279 1112204014362 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1112204014363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204014364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1112204014365 NAD(P) binding site [chemical binding]; other site 1112204014366 active site 1112204014367 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1112204014368 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1112204014369 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1112204014370 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1112204014371 Walker A/P-loop; other site 1112204014372 ATP binding site [chemical binding]; other site 1112204014373 Q-loop/lid; other site 1112204014374 ABC transporter signature motif; other site 1112204014375 Walker B; other site 1112204014376 D-loop; other site 1112204014377 H-loop/switch region; other site 1112204014378 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1112204014379 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1112204014380 Walker A/P-loop; other site 1112204014381 ATP binding site [chemical binding]; other site 1112204014382 Q-loop/lid; other site 1112204014383 ABC transporter signature motif; other site 1112204014384 Walker B; other site 1112204014385 D-loop; other site 1112204014386 H-loop/switch region; other site 1112204014387 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204014388 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204014389 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1112204014390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1112204014391 active site 1112204014392 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 1112204014393 hypothetical protein; Validated; Region: PRK07198 1112204014394 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 1112204014395 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1112204014396 dimerization interface [polypeptide binding]; other site 1112204014397 active site 1112204014398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204014399 S-adenosylmethionine binding site [chemical binding]; other site 1112204014400 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1112204014401 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1112204014402 heme binding site [chemical binding]; other site 1112204014403 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1112204014404 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1112204014405 metal binding site 2 [ion binding]; metal-binding site 1112204014406 putative DNA binding helix; other site 1112204014407 metal binding site 1 [ion binding]; metal-binding site 1112204014408 dimer interface [polypeptide binding]; other site 1112204014409 structural Zn2+ binding site [ion binding]; other site 1112204014410 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204014411 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1112204014412 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1112204014413 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1112204014414 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1112204014415 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1112204014416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1112204014417 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1112204014418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204014419 dimerization interface [polypeptide binding]; other site 1112204014420 putative DNA binding site [nucleotide binding]; other site 1112204014421 putative Zn2+ binding site [ion binding]; other site 1112204014422 Sodium Bile acid symporter family; Region: SBF; cl17470 1112204014423 YceI-like domain; Region: YceI; smart00867 1112204014424 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1112204014425 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1112204014426 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1112204014427 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1112204014428 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1112204014429 carboxyltransferase (CT) interaction site; other site 1112204014430 biotinylation site [posttranslational modification]; other site 1112204014431 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1112204014432 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1112204014433 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1112204014434 putative active site [active] 1112204014435 putative metal binding site [ion binding]; other site 1112204014436 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1112204014437 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1112204014438 hydrophobic ligand binding site; other site 1112204014439 glutamate dehydrogenase; Provisional; Region: PRK09414 1112204014440 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1112204014441 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1112204014442 NAD(P) binding site [chemical binding]; other site 1112204014443 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1112204014444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1112204014445 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1112204014446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1112204014447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1112204014448 S-adenosylmethionine binding site [chemical binding]; other site 1112204014449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1112204014450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1112204014451 active site 1112204014452 catalytic tetrad [active] 1112204014453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1112204014454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204014455 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1112204014456 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1112204014457 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1112204014458 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1112204014459 PemK-like protein; Region: PemK; pfam02452 1112204014460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204014461 putative DNA binding site [nucleotide binding]; other site 1112204014462 putative Zn2+ binding site [ion binding]; other site 1112204014463 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1112204014464 arsenical-resistance protein; Region: acr3; TIGR00832 1112204014465 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1112204014466 active site 1112204014467 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1112204014468 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1112204014469 putative metal binding site [ion binding]; other site 1112204014470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1112204014471 dimerization interface [polypeptide binding]; other site 1112204014472 putative DNA binding site [nucleotide binding]; other site 1112204014473 putative Zn2+ binding site [ion binding]; other site 1112204014474 AAA domain; Region: AAA_22; pfam13401 1112204014475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1112204014476 Walker A motif; other site 1112204014477 ATP binding site [chemical binding]; other site 1112204014478 Walker B motif; other site 1112204014479 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1112204014480 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1112204014481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1112204014482 NAD(P) binding site [chemical binding]; other site 1112204014483 active site 1112204014484 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1112204014485 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204014486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1112204014487 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1112204014488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1112204014489 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1112204014490 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204014491 MULE transposase domain; Region: MULE; pfam10551 1112204014492 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1112204014493 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204014494 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1112204014495 MULE transposase domain; Region: MULE; pfam10551