-- dump date   	20140619_103935
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
391165000001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165000002	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391165000003	putative substrate translocation pore; other site
391165000004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165000005	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
391165000006	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
391165000007	substrate binding site [chemical binding]; other site
391165000008	active site
391165000009	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
391165000010	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
391165000011	putative active site [active]
391165000012	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
391165000013	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
391165000014	HIGH motif; other site
391165000015	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
391165000016	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391165000017	active site
391165000018	KMSKS motif; other site
391165000019	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
391165000020	tRNA binding surface [nucleotide binding]; other site
391165000021	Lipopolysaccharide-assembly; Region: LptE; pfam04390
391165000022	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
391165000023	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
391165000024	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
391165000025	ParB-like nuclease domain; Region: ParB; smart00470
391165000026	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
391165000027	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391165000028	P-loop; other site
391165000029	Magnesium ion binding site [ion binding]; other site
391165000030	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391165000031	Magnesium ion binding site [ion binding]; other site
391165000032	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
391165000033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165000034	S-adenosylmethionine binding site [chemical binding]; other site
391165000035	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
391165000036	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
391165000037	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
391165000038	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
391165000039	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
391165000040	trmE is a tRNA modification GTPase; Region: trmE; cd04164
391165000041	G1 box; other site
391165000042	GTP/Mg2+ binding site [chemical binding]; other site
391165000043	Switch I region; other site
391165000044	G2 box; other site
391165000045	Switch II region; other site
391165000046	G3 box; other site
391165000047	G4 box; other site
391165000048	G5 box; other site
391165000049	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
391165000050	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
391165000051	dimer interface [polypeptide binding]; other site
391165000052	[2Fe-2S] cluster binding site [ion binding]; other site
391165000053	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
391165000054	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
391165000055	catalytic residues [active]
391165000056	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
391165000057	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
391165000058	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
391165000059	DNA binding site [nucleotide binding]
391165000060	active site
391165000061	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
391165000062	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
391165000063	NADP binding site [chemical binding]; other site
391165000064	dimer interface [polypeptide binding]; other site
391165000065	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
391165000066	DNA-binding site [nucleotide binding]; DNA binding site
391165000067	RNA-binding motif; other site
391165000068	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
391165000069	IHF - DNA interface [nucleotide binding]; other site
391165000070	IHF dimer interface [polypeptide binding]; other site
391165000071	manganese transport protein MntH; Reviewed; Region: PRK00701
391165000072	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
391165000073	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391165000074	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165000075	Walker A/P-loop; other site
391165000076	ATP binding site [chemical binding]; other site
391165000077	Q-loop/lid; other site
391165000078	ABC transporter signature motif; other site
391165000079	Walker B; other site
391165000080	D-loop; other site
391165000081	H-loop/switch region; other site
391165000082	chaperone protein DnaJ; Provisional; Region: PRK10767
391165000083	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391165000084	HSP70 interaction site [polypeptide binding]; other site
391165000085	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
391165000086	Zn binding sites [ion binding]; other site
391165000087	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
391165000088	dimer interface [polypeptide binding]; other site
391165000089	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
391165000090	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
391165000091	nucleotide binding site [chemical binding]; other site
391165000092	NEF interaction site [polypeptide binding]; other site
391165000093	SBD interface [polypeptide binding]; other site
391165000094	GrpE; Region: GrpE; pfam01025
391165000095	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
391165000096	dimer interface [polypeptide binding]; other site
391165000097	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
391165000098	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
391165000099	ribonuclease PH; Reviewed; Region: rph; PRK00173
391165000100	Ribonuclease PH; Region: RNase_PH_bact; cd11362
391165000101	hexamer interface [polypeptide binding]; other site
391165000102	active site
391165000103	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
391165000104	active site
391165000105	dimerization interface [polypeptide binding]; other site
391165000106	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
391165000107	putative FMN binding site [chemical binding]; other site
391165000108	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
391165000109	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165000110	FeS/SAM binding site; other site
391165000111	HemN C-terminal domain; Region: HemN_C; pfam06969
391165000112	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
391165000113	active site 2 [active]
391165000114	active site 1 [active]
391165000115	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
391165000116	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
391165000117	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
391165000118	dimer interface [polypeptide binding]; other site
391165000119	active site
391165000120	Predicted exporter [General function prediction only]; Region: COG4258
391165000121	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
391165000122	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
391165000123	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
391165000124	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
391165000125	putative acyl-acceptor binding pocket; other site
391165000126	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
391165000127	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
391165000128	acyl-activating enzyme (AAE) consensus motif; other site
391165000129	AMP binding site [chemical binding]; other site
391165000130	active site
391165000131	CoA binding site [chemical binding]; other site
391165000132	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
391165000133	putative active site [active]
391165000134	putative catalytic site [active]
391165000135	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
391165000136	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
391165000137	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
391165000138	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
391165000139	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
391165000140	Copper resistance protein D; Region: CopD; cl00563
391165000141	CopC domain; Region: CopC; pfam04234
391165000142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
391165000143	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
391165000144	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
391165000145	Potassium binding sites [ion binding]; other site
391165000146	Cesium cation binding sites [ion binding]; other site
391165000147	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
391165000148	homodimer interface [polypeptide binding]; other site
391165000149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165000150	catalytic residue [active]
391165000151	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
391165000152	glycerate dehydrogenase; Provisional; Region: PRK06487
391165000153	putative ligand binding site [chemical binding]; other site
391165000154	putative NAD binding site [chemical binding]; other site
391165000155	catalytic site [active]
391165000156	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
391165000157	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
391165000158	NADP binding site [chemical binding]; other site
391165000159	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
391165000160	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
391165000161	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
391165000162	CoA-ligase; Region: Ligase_CoA; pfam00549
391165000163	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
391165000164	CoA binding domain; Region: CoA_binding; pfam02629
391165000165	CoA-ligase; Region: Ligase_CoA; pfam00549
391165000166	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
391165000167	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
391165000168	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
391165000169	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
391165000170	active site clefts [active]
391165000171	zinc binding site [ion binding]; other site
391165000172	dimer interface [polypeptide binding]; other site
391165000173	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
391165000174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165000175	NAD(P) binding site [chemical binding]; other site
391165000176	active site
391165000177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165000178	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
391165000179	putative substrate translocation pore; other site
391165000180	transcription termination factor Rho; Provisional; Region: rho; PRK09376
391165000181	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
391165000182	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
391165000183	RNA binding site [nucleotide binding]; other site
391165000184	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
391165000185	multimer interface [polypeptide binding]; other site
391165000186	Walker A motif; other site
391165000187	ATP binding site [chemical binding]; other site
391165000188	Walker B motif; other site
391165000189	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
391165000190	active site
391165000191	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
391165000192	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
391165000193	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
391165000194	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
391165000195	homotetramer interface [polypeptide binding]; other site
391165000196	ligand binding site [chemical binding]; other site
391165000197	catalytic site [active]
391165000198	NAD binding site [chemical binding]; other site
391165000199	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
391165000200	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
391165000201	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
391165000202	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
391165000203	catalytic triad [active]
391165000204	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391165000205	catalytic core [active]
391165000206	Electron transfer flavoprotein domain; Region: ETF; pfam01012
391165000207	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
391165000208	Ligand binding site [chemical binding]; other site
391165000209	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
391165000210	Ligand Binding Site [chemical binding]; other site
391165000211	Electron transfer flavoprotein domain; Region: ETF; smart00893
391165000212	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
391165000213	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
391165000214	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
391165000215	4Fe-4S binding domain; Region: Fer4; cl02805
391165000216	Cysteine-rich domain; Region: CCG; pfam02754
391165000217	Cysteine-rich domain; Region: CCG; pfam02754
391165000218	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
391165000219	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
391165000220	putative active site [active]
391165000221	putative FMN binding site [chemical binding]; other site
391165000222	putative substrate binding site [chemical binding]; other site
391165000223	putative catalytic residue [active]
391165000224	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165000225	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
391165000226	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
391165000227	conserved cys residue [active]
391165000228	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
391165000229	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
391165000230	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
391165000231	FAD binding pocket [chemical binding]; other site
391165000232	FAD binding motif [chemical binding]; other site
391165000233	phosphate binding motif [ion binding]; other site
391165000234	beta-alpha-beta structure motif; other site
391165000235	NAD binding pocket [chemical binding]; other site
391165000236	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391165000237	catalytic loop [active]
391165000238	iron binding site [ion binding]; other site
391165000239	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
391165000240	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
391165000241	[2Fe-2S] cluster binding site [ion binding]; other site
391165000242	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
391165000243	putative alpha subunit interface [polypeptide binding]; other site
391165000244	putative active site [active]
391165000245	putative substrate binding site [chemical binding]; other site
391165000246	Fe binding site [ion binding]; other site
391165000247	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
391165000248	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
391165000249	conserved cys residue [active]
391165000250	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
391165000251	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
391165000252	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
391165000253	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
391165000254	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
391165000255	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
391165000256	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
391165000257	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
391165000258	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
391165000259	hydroxyglutarate oxidase; Provisional; Region: PRK11728
391165000260	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
391165000261	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
391165000262	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
391165000263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165000264	dimer interface [polypeptide binding]; other site
391165000265	conserved gate region; other site
391165000266	ABC-ATPase subunit interface; other site
391165000267	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
391165000268	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165000269	Walker A/P-loop; other site
391165000270	ATP binding site [chemical binding]; other site
391165000271	Q-loop/lid; other site
391165000272	ABC transporter signature motif; other site
391165000273	Walker B; other site
391165000274	D-loop; other site
391165000275	H-loop/switch region; other site
391165000276	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
391165000277	GTP cyclohydrolase I; Provisional; Region: PLN03044
391165000278	active site
391165000279	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
391165000280	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
391165000281	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
391165000282	homodimer interface [polypeptide binding]; other site
391165000283	substrate-cofactor binding pocket; other site
391165000284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165000285	catalytic residue [active]
391165000286	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
391165000287	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
391165000288	potential catalytic triad [active]
391165000289	conserved cys residue [active]
391165000290	Domain of unknown function (DUF892); Region: DUF892; pfam05974
391165000291	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
391165000292	dimerization interface [polypeptide binding]; other site
391165000293	metal binding site [ion binding]; metal-binding site
391165000294	short chain dehydrogenase; Provisional; Region: PRK06701
391165000295	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
391165000296	NAD binding site [chemical binding]; other site
391165000297	metal binding site [ion binding]; metal-binding site
391165000298	active site
391165000299	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
391165000300	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
391165000301	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
391165000302	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
391165000303	Cation efflux family; Region: Cation_efflux; pfam01545
391165000304	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
391165000305	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
391165000306	putative NAD(P) binding site [chemical binding]; other site
391165000307	Bacterial PH domain; Region: DUF304; pfam03703
391165000308	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
391165000309	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
391165000310	active site
391165000311	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
391165000312	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
391165000313	NAD binding site [chemical binding]; other site
391165000314	substrate binding site [chemical binding]; other site
391165000315	homodimer interface [polypeptide binding]; other site
391165000316	active site
391165000317	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
391165000318	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
391165000319	substrate binding site; other site
391165000320	tetramer interface; other site
391165000321	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
391165000322	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
391165000323	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
391165000324	NADP binding site [chemical binding]; other site
391165000325	active site
391165000326	putative substrate binding site [chemical binding]; other site
391165000327	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391165000328	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
391165000329	Probable Catalytic site; other site
391165000330	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
391165000331	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
391165000332	ThiC-associated domain; Region: ThiC-associated; pfam13667
391165000333	ThiC family; Region: ThiC; pfam01964
391165000334	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
391165000335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165000336	binding surface
391165000337	Tetratricopeptide repeat; Region: TPR_9; pfam13371
391165000338	TPR motif; other site
391165000339	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
391165000340	Proline dehydrogenase; Region: Pro_dh; pfam01619
391165000341	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
391165000342	NAD(P) binding site [chemical binding]; other site
391165000343	catalytic residues [active]
391165000344	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
391165000345	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
391165000346	heme binding site [chemical binding]; other site
391165000347	ferroxidase pore; other site
391165000348	ferroxidase diiron center [ion binding]; other site
391165000349	glutathione synthetase; Provisional; Region: PRK05246
391165000350	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
391165000351	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
391165000352	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165000353	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
391165000354	active site
391165000355	motif I; other site
391165000356	motif II; other site
391165000357	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
391165000358	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
391165000359	putative active site [active]
391165000360	catalytic site [active]
391165000361	putative metal binding site [ion binding]; other site
391165000362	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
391165000363	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
391165000364	Transporter associated domain; Region: CorC_HlyC; smart01091
391165000365	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
391165000366	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
391165000367	PhoH-like protein; Region: PhoH; pfam02562
391165000368	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
391165000369	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
391165000370	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165000371	FeS/SAM binding site; other site
391165000372	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
391165000373	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391165000374	putative acyl-acceptor binding pocket; other site
391165000375	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
391165000376	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391165000377	Surface antigen; Region: Bac_surface_Ag; pfam01103
391165000378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
391165000379	Family of unknown function (DUF490); Region: DUF490; pfam04357
391165000380	Family of unknown function (DUF490); Region: DUF490; pfam04357
391165000381	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
391165000382	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
391165000383	Trp docking motif [polypeptide binding]; other site
391165000384	dimer interface [polypeptide binding]; other site
391165000385	active site
391165000386	small subunit binding site [polypeptide binding]; other site
391165000387	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391165000388	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
391165000389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165000390	dimer interface [polypeptide binding]; other site
391165000391	conserved gate region; other site
391165000392	putative PBP binding loops; other site
391165000393	ABC-ATPase subunit interface; other site
391165000394	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391165000395	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165000396	dimer interface [polypeptide binding]; other site
391165000397	conserved gate region; other site
391165000398	putative PBP binding loops; other site
391165000399	ABC-ATPase subunit interface; other site
391165000400	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391165000401	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
391165000402	CreA protein; Region: CreA; pfam05981
391165000403	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
391165000404	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
391165000405	catalytic residues [active]
391165000406	argininosuccinate lyase; Provisional; Region: PRK00855
391165000407	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
391165000408	active sites [active]
391165000409	tetramer interface [polypeptide binding]; other site
391165000410	diaminopimelate decarboxylase; Region: lysA; TIGR01048
391165000411	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
391165000412	active site
391165000413	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391165000414	substrate binding site [chemical binding]; other site
391165000415	catalytic residues [active]
391165000416	dimer interface [polypeptide binding]; other site
391165000417	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
391165000418	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
391165000419	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391165000420	Walker A/P-loop; other site
391165000421	ATP binding site [chemical binding]; other site
391165000422	Q-loop/lid; other site
391165000423	ABC transporter signature motif; other site
391165000424	Walker B; other site
391165000425	D-loop; other site
391165000426	H-loop/switch region; other site
391165000427	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
391165000428	Uncharacterized conserved protein [Function unknown]; Region: COG1434
391165000429	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
391165000430	putative active site [active]
391165000431	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
391165000432	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391165000433	putative acyl-acceptor binding pocket; other site
391165000434	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
391165000435	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
391165000436	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
391165000437	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
391165000438	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
391165000439	prephenate dehydrogenase; Validated; Region: PRK08507
391165000440	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
391165000441	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391165000442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165000443	homodimer interface [polypeptide binding]; other site
391165000444	catalytic residue [active]
391165000445	hypothetical protein; Provisional; Region: PRK06034
391165000446	Chorismate mutase type II; Region: CM_2; smart00830
391165000447	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
391165000448	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
391165000449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165000450	S-adenosylmethionine binding site [chemical binding]; other site
391165000451	Predicted membrane protein [Function unknown]; Region: COG2261
391165000452	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
391165000453	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391165000454	dimerization interface [polypeptide binding]; other site
391165000455	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
391165000456	dimer interface [polypeptide binding]; other site
391165000457	phosphorylation site [posttranslational modification]
391165000458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165000459	ATP binding site [chemical binding]; other site
391165000460	Mg2+ binding site [ion binding]; other site
391165000461	G-X-G motif; other site
391165000462	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165000463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165000464	active site
391165000465	phosphorylation site [posttranslational modification]
391165000466	intermolecular recognition site; other site
391165000467	dimerization interface [polypeptide binding]; other site
391165000468	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165000469	DNA binding site [nucleotide binding]
391165000470	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
391165000471	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
391165000472	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391165000473	protein binding site [polypeptide binding]; other site
391165000474	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
391165000475	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391165000476	ATP binding site [chemical binding]; other site
391165000477	putative Mg++ binding site [ion binding]; other site
391165000478	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165000479	nucleotide binding region [chemical binding]; other site
391165000480	Helicase associated domain (HA2); Region: HA2; pfam04408
391165000481	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
391165000482	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
391165000483	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
391165000484	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
391165000485	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
391165000486	DsbD alpha interface [polypeptide binding]; other site
391165000487	catalytic residues [active]
391165000488	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
391165000489	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
391165000490	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
391165000491	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
391165000492	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
391165000493	substrate binding pocket [chemical binding]; other site
391165000494	dimer interface [polypeptide binding]; other site
391165000495	inhibitor binding site; inhibition site
391165000496	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
391165000497	B12 binding site [chemical binding]; other site
391165000498	cobalt ligand [ion binding]; other site
391165000499	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
391165000500	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391165000501	dimerization interface [polypeptide binding]; other site
391165000502	putative DNA binding site [nucleotide binding]; other site
391165000503	putative Zn2+ binding site [ion binding]; other site
391165000504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165000505	S-adenosylmethionine binding site [chemical binding]; other site
391165000506	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
391165000507	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
391165000508	Walker A/P-loop; other site
391165000509	ATP binding site [chemical binding]; other site
391165000510	Q-loop/lid; other site
391165000511	ABC transporter signature motif; other site
391165000512	Walker B; other site
391165000513	D-loop; other site
391165000514	H-loop/switch region; other site
391165000515	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
391165000516	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
391165000517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165000518	dimer interface [polypeptide binding]; other site
391165000519	conserved gate region; other site
391165000520	putative PBP binding loops; other site
391165000521	ABC-ATPase subunit interface; other site
391165000522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165000523	dimer interface [polypeptide binding]; other site
391165000524	conserved gate region; other site
391165000525	putative PBP binding loops; other site
391165000526	ABC-ATPase subunit interface; other site
391165000527	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
391165000528	trimer interface [polypeptide binding]; other site
391165000529	active site
391165000530	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
391165000531	Flavoprotein; Region: Flavoprotein; pfam02441
391165000532	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
391165000533	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
391165000534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165000535	S-adenosylmethionine binding site [chemical binding]; other site
391165000536	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
391165000537	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
391165000538	DNA binding site [nucleotide binding]
391165000539	catalytic residue [active]
391165000540	H2TH interface [polypeptide binding]; other site
391165000541	putative catalytic residues [active]
391165000542	turnover-facilitating residue; other site
391165000543	intercalation triad [nucleotide binding]; other site
391165000544	8OG recognition residue [nucleotide binding]; other site
391165000545	putative reading head residues; other site
391165000546	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
391165000547	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
391165000548	DnaA N-terminal domain; Region: DnaA_N; pfam11638
391165000549	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
391165000550	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165000551	Walker A motif; other site
391165000552	ATP binding site [chemical binding]; other site
391165000553	Walker B motif; other site
391165000554	arginine finger; other site
391165000555	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
391165000556	DnaA box-binding interface [nucleotide binding]; other site
391165000557	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
391165000558	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
391165000559	Mg++ binding site [ion binding]; other site
391165000560	putative catalytic motif [active]
391165000561	substrate binding site [chemical binding]; other site
391165000562	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
391165000563	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
391165000564	NAD(P) binding site [chemical binding]; other site
391165000565	homodimer interface [polypeptide binding]; other site
391165000566	substrate binding site [chemical binding]; other site
391165000567	active site
391165000568	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
391165000569	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
391165000570	inhibitor-cofactor binding pocket; inhibition site
391165000571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165000572	catalytic residue [active]
391165000573	Protein of unknown function (DUF423); Region: DUF423; pfam04241
391165000574	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
391165000575	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
391165000576	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
391165000577	putative C-terminal domain interface [polypeptide binding]; other site
391165000578	putative GSH binding site (G-site) [chemical binding]; other site
391165000579	putative dimer interface [polypeptide binding]; other site
391165000580	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
391165000581	putative N-terminal domain interface [polypeptide binding]; other site
391165000582	putative dimer interface [polypeptide binding]; other site
391165000583	putative substrate binding pocket (H-site) [chemical binding]; other site
391165000584	O-Antigen ligase; Region: Wzy_C; pfam04932
391165000585	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
391165000586	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
391165000587	P-loop, Walker A motif; other site
391165000588	Base recognition motif; other site
391165000589	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
391165000590	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
391165000591	structural tetrad; other site
391165000592	FOG: WD40 repeat [General function prediction only]; Region: COG2319
391165000593	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
391165000594	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
391165000595	N-terminal plug; other site
391165000596	ligand-binding site [chemical binding]; other site
391165000597	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
391165000598	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
391165000599	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
391165000600	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
391165000601	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
391165000602	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
391165000603	hydroxyglutarate oxidase; Provisional; Region: PRK11728
391165000604	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165000605	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165000606	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
391165000607	dimerization interface [polypeptide binding]; other site
391165000608	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391165000609	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165000610	non-specific DNA binding site [nucleotide binding]; other site
391165000611	salt bridge; other site
391165000612	sequence-specific DNA binding site [nucleotide binding]; other site
391165000613	Cupin domain; Region: Cupin_2; cl17218
391165000614	Cupin domain; Region: Cupin_2; pfam07883
391165000615	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
391165000616	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
391165000617	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391165000618	Soluble P-type ATPase [General function prediction only]; Region: COG4087
391165000619	K+-transporting ATPase, c chain; Region: KdpC; cl00944
391165000620	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
391165000621	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
391165000622	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
391165000623	Ligand Binding Site [chemical binding]; other site
391165000624	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
391165000625	GAF domain; Region: GAF_3; pfam13492
391165000626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165000627	dimer interface [polypeptide binding]; other site
391165000628	phosphorylation site [posttranslational modification]
391165000629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165000630	ATP binding site [chemical binding]; other site
391165000631	Mg2+ binding site [ion binding]; other site
391165000632	G-X-G motif; other site
391165000633	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165000634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165000635	active site
391165000636	phosphorylation site [posttranslational modification]
391165000637	intermolecular recognition site; other site
391165000638	dimerization interface [polypeptide binding]; other site
391165000639	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165000640	DNA binding site [nucleotide binding]
391165000641	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
391165000642	ArsC family; Region: ArsC; pfam03960
391165000643	catalytic residues [active]
391165000644	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
391165000645	Paraquat-inducible protein A; Region: PqiA; pfam04403
391165000646	Paraquat-inducible protein A; Region: PqiA; pfam04403
391165000647	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
391165000648	mce related protein; Region: MCE; pfam02470
391165000649	mce related protein; Region: MCE; pfam02470
391165000650	Protein of unknown function (DUF330); Region: DUF330; pfam03886
391165000651	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
391165000652	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391165000653	Coenzyme A binding pocket [chemical binding]; other site
391165000654	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
391165000655	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
391165000656	putative active site [active]
391165000657	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391165000658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165000659	Walker A/P-loop; other site
391165000660	ATP binding site [chemical binding]; other site
391165000661	Q-loop/lid; other site
391165000662	ABC transporter signature motif; other site
391165000663	Walker B; other site
391165000664	D-loop; other site
391165000665	H-loop/switch region; other site
391165000666	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
391165000667	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
391165000668	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165000669	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
391165000670	Sel1-like repeats; Region: SEL1; smart00671
391165000671	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
391165000672	Sel1-like repeats; Region: SEL1; smart00671
391165000673	Sel1-like repeats; Region: SEL1; smart00671
391165000674	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
391165000675	Sel1-like repeats; Region: SEL1; smart00671
391165000676	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391165000677	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
391165000678	Probable Catalytic site; other site
391165000679	metal-binding site
391165000680	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
391165000681	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165000682	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165000683	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
391165000684	putative ADP-binding pocket [chemical binding]; other site
391165000685	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
391165000686	dimer interface [polypeptide binding]; other site
391165000687	substrate binding site [chemical binding]; other site
391165000688	metal binding sites [ion binding]; metal-binding site
391165000689	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
391165000690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165000691	Walker A/P-loop; other site
391165000692	ATP binding site [chemical binding]; other site
391165000693	Q-loop/lid; other site
391165000694	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391165000695	ABC transporter; Region: ABC_tran_2; pfam12848
391165000696	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391165000697	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391165000698	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165000699	PQQ-like domain; Region: PQQ_2; pfam13360
391165000700	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165000701	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165000702	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165000703	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165000704	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165000705	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
391165000706	putative hydrophobic ligand binding site [chemical binding]; other site
391165000707	protein interface [polypeptide binding]; other site
391165000708	gate; other site
391165000709	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
391165000710	VacJ like lipoprotein; Region: VacJ; cl01073
391165000711	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
391165000712	FAD binding site [chemical binding]; other site
391165000713	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
391165000714	Part of AAA domain; Region: AAA_19; pfam13245
391165000715	Family description; Region: UvrD_C_2; pfam13538
391165000716	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
391165000717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165000718	S-adenosylmethionine binding site [chemical binding]; other site
391165000719	exopolyphosphatase; Region: exo_poly_only; TIGR03706
391165000720	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
391165000721	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
391165000722	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
391165000723	catalytic site [active]
391165000724	putative active site [active]
391165000725	putative substrate binding site [chemical binding]; other site
391165000726	HRDC domain; Region: HRDC; pfam00570
391165000727	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
391165000728	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
391165000729	Cl binding site [ion binding]; other site
391165000730	oligomer interface [polypeptide binding]; other site
391165000731	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
391165000732	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
391165000733	dimer interface [polypeptide binding]; other site
391165000734	anticodon binding site; other site
391165000735	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
391165000736	homodimer interface [polypeptide binding]; other site
391165000737	motif 1; other site
391165000738	active site
391165000739	motif 2; other site
391165000740	GAD domain; Region: GAD; pfam02938
391165000741	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391165000742	active site
391165000743	motif 3; other site
391165000744	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
391165000745	DNA polymerase IV; Provisional; Region: PRK02794
391165000746	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
391165000747	active site
391165000748	DNA binding site [nucleotide binding]
391165000749	fructokinase; Reviewed; Region: PRK09557
391165000750	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391165000751	nucleotide binding site [chemical binding]; other site
391165000752	Butyrate kinase [Energy production and conversion]; Region: COG3426
391165000753	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
391165000754	CPxP  motif; other site
391165000755	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
391165000756	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
391165000757	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
391165000758	substrate binding pocket [chemical binding]; other site
391165000759	chain length determination region; other site
391165000760	substrate-Mg2+ binding site; other site
391165000761	catalytic residues [active]
391165000762	aspartate-rich region 1; other site
391165000763	active site lid residues [active]
391165000764	aspartate-rich region 2; other site
391165000765	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
391165000766	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
391165000767	TPP-binding site; other site
391165000768	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
391165000769	PYR/PP interface [polypeptide binding]; other site
391165000770	dimer interface [polypeptide binding]; other site
391165000771	TPP binding site [chemical binding]; other site
391165000772	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391165000773	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
391165000774	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391165000775	RNA binding surface [nucleotide binding]; other site
391165000776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165000777	S-adenosylmethionine binding site [chemical binding]; other site
391165000778	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
391165000779	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
391165000780	acyl-activating enzyme (AAE) consensus motif; other site
391165000781	AMP binding site [chemical binding]; other site
391165000782	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
391165000783	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
391165000784	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
391165000785	putative trimer interface [polypeptide binding]; other site
391165000786	putative CoA binding site [chemical binding]; other site
391165000787	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
391165000788	putative trimer interface [polypeptide binding]; other site
391165000789	putative CoA binding site [chemical binding]; other site
391165000790	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
391165000791	putative trimer interface [polypeptide binding]; other site
391165000792	putative CoA binding site [chemical binding]; other site
391165000793	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
391165000794	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
391165000795	Tetramer interface [polypeptide binding]; other site
391165000796	active site
391165000797	FMN-binding site [chemical binding]; other site
391165000798	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
391165000799	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
391165000800	NAD binding site [chemical binding]; other site
391165000801	homotetramer interface [polypeptide binding]; other site
391165000802	homodimer interface [polypeptide binding]; other site
391165000803	substrate binding site [chemical binding]; other site
391165000804	active site
391165000805	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
391165000806	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
391165000807	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
391165000808	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165000809	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579
391165000810	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
391165000811	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
391165000812	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
391165000813	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
391165000814	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165000815	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
391165000816	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
391165000817	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
391165000818	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
391165000819	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
391165000820	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391165000821	active site
391165000822	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
391165000823	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
391165000824	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391165000825	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391165000826	catalytic residue [active]
391165000827	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
391165000828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165000829	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
391165000830	NAD(P) binding site [chemical binding]; other site
391165000831	active site
391165000832	acyl-CoA synthetase; Validated; Region: PRK09192
391165000833	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
391165000834	acyl-activating enzyme (AAE) consensus motif; other site
391165000835	active site
391165000836	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
391165000837	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
391165000838	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
391165000839	putative ADP-binding pocket [chemical binding]; other site
391165000840	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165000841	Radical SAM superfamily; Region: Radical_SAM; pfam04055
391165000842	FeS/SAM binding site; other site
391165000843	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
391165000844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165000845	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
391165000846	Predicted permeases [General function prediction only]; Region: COG0795
391165000847	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
391165000848	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
391165000849	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
391165000850	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
391165000851	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
391165000852	catalytic residues [active]
391165000853	Uncharacterized conserved protein [Function unknown]; Region: COG2835
391165000854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
391165000855	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391165000856	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391165000857	active site
391165000858	catalytic tetrad [active]
391165000859	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
391165000860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
391165000861	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
391165000862	putative active site [active]
391165000863	heme pocket [chemical binding]; other site
391165000864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
391165000865	putative active site [active]
391165000866	heme pocket [chemical binding]; other site
391165000867	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165000868	dimer interface [polypeptide binding]; other site
391165000869	phosphorylation site [posttranslational modification]
391165000870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165000871	ATP binding site [chemical binding]; other site
391165000872	Mg2+ binding site [ion binding]; other site
391165000873	G-X-G motif; other site
391165000874	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
391165000875	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
391165000876	active site
391165000877	dimer interface [polypeptide binding]; other site
391165000878	non-prolyl cis peptide bond; other site
391165000879	insertion regions; other site
391165000880	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
391165000881	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391165000882	substrate binding pocket [chemical binding]; other site
391165000883	membrane-bound complex binding site; other site
391165000884	hinge residues; other site
391165000885	recombination protein RecR; Reviewed; Region: recR; PRK00076
391165000886	RecR protein; Region: RecR; pfam02132
391165000887	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
391165000888	putative active site [active]
391165000889	putative metal-binding site [ion binding]; other site
391165000890	tetramer interface [polypeptide binding]; other site
391165000891	hypothetical protein; Validated; Region: PRK00153
391165000892	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
391165000893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165000894	Walker A motif; other site
391165000895	ATP binding site [chemical binding]; other site
391165000896	Walker B motif; other site
391165000897	arginine finger; other site
391165000898	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
391165000899	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
391165000900	argininosuccinate synthase; Provisional; Region: PRK13820
391165000901	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
391165000902	ANP binding site [chemical binding]; other site
391165000903	Substrate Binding Site II [chemical binding]; other site
391165000904	Substrate Binding Site I [chemical binding]; other site
391165000905	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
391165000906	acetyl-CoA synthetase; Provisional; Region: PRK00174
391165000907	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
391165000908	active site
391165000909	CoA binding site [chemical binding]; other site
391165000910	acyl-activating enzyme (AAE) consensus motif; other site
391165000911	AMP binding site [chemical binding]; other site
391165000912	acetate binding site [chemical binding]; other site
391165000913	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
391165000914	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
391165000915	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
391165000916	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
391165000917	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
391165000918	catalytic residues [active]
391165000919	central insert; other site
391165000920	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
391165000921	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
391165000922	heme exporter protein CcmC; Region: ccmC; TIGR01191
391165000923	YciI-like protein; Reviewed; Region: PRK12863
391165000924	EVE domain; Region: EVE; pfam01878
391165000925	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
391165000926	iron-sulfur cluster [ion binding]; other site
391165000927	[2Fe-2S] cluster binding site [ion binding]; other site
391165000928	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
391165000929	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
391165000930	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
391165000931	YGGT family; Region: YGGT; pfam02325
391165000932	benzoate transport; Region: 2A0115; TIGR00895
391165000933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165000934	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165000935	peptide chain release factor 2; Provisional; Region: PRK07342
391165000936	This domain is found in peptide chain release factors; Region: PCRF; smart00937
391165000937	RF-1 domain; Region: RF-1; pfam00472
391165000938	Transglycosylase; Region: Transgly; pfam00912
391165000939	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
391165000940	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
391165000941	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
391165000942	active site
391165000943	metal binding site [ion binding]; metal-binding site
391165000944	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
391165000945	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391165000946	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
391165000947	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
391165000948	heme binding pocket [chemical binding]; other site
391165000949	heme ligand [chemical binding]; other site
391165000950	NAD synthetase; Reviewed; Region: nadE; PRK02628
391165000951	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
391165000952	multimer interface [polypeptide binding]; other site
391165000953	active site
391165000954	catalytic triad [active]
391165000955	protein interface 1 [polypeptide binding]; other site
391165000956	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
391165000957	homodimer interface [polypeptide binding]; other site
391165000958	NAD binding pocket [chemical binding]; other site
391165000959	ATP binding pocket [chemical binding]; other site
391165000960	Mg binding site [ion binding]; other site
391165000961	active-site loop [active]
391165000962	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
391165000963	dimer interface [polypeptide binding]; other site
391165000964	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
391165000965	metal binding site [ion binding]; metal-binding site
391165000966	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
391165000967	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
391165000968	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
391165000969	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
391165000970	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
391165000971	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
391165000972	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
391165000973	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
391165000974	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
391165000975	active site
391165000976	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165000977	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165000978	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
391165000979	putative effector binding pocket; other site
391165000980	dimerization interface [polypeptide binding]; other site
391165000981	epoxyqueuosine reductase; Region: TIGR00276
391165000982	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
391165000983	4Fe-4S binding domain; Region: Fer4; cl02805
391165000984	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
391165000985	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
391165000986	active site
391165000987	NTP binding site [chemical binding]; other site
391165000988	metal binding triad [ion binding]; metal-binding site
391165000989	antibiotic binding site [chemical binding]; other site
391165000990	Cupin domain; Region: Cupin_2; cl17218
391165000991	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
391165000992	Methyltransferase domain; Region: Methyltransf_23; pfam13489
391165000993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165000994	S-adenosylmethionine binding site [chemical binding]; other site
391165000995	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
391165000996	substrate binding site [chemical binding]; other site
391165000997	multimerization interface [polypeptide binding]; other site
391165000998	ATP binding site [chemical binding]; other site
391165000999	CsbD-like; Region: CsbD; pfam05532
391165001000	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
391165001001	Domain of unknown function DUF20; Region: UPF0118; pfam01594
391165001002	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
391165001003	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
391165001004	substrate-cofactor binding pocket; other site
391165001005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165001006	catalytic residue [active]
391165001007	allantoate amidohydrolase; Reviewed; Region: PRK09290
391165001008	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
391165001009	active site
391165001010	metal binding site [ion binding]; metal-binding site
391165001011	dimer interface [polypeptide binding]; other site
391165001012	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
391165001013	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
391165001014	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
391165001015	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
391165001016	Phosphoglycerate kinase; Region: PGK; pfam00162
391165001017	substrate binding site [chemical binding]; other site
391165001018	hinge regions; other site
391165001019	ADP binding site [chemical binding]; other site
391165001020	catalytic site [active]
391165001021	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
391165001022	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
391165001023	4Fe-4S binding domain; Region: Fer4; pfam00037
391165001024	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
391165001025	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165001026	nucleotide binding region [chemical binding]; other site
391165001027	ATP-binding site [chemical binding]; other site
391165001028	heat shock protein 90; Provisional; Region: PRK05218
391165001029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165001030	ATP binding site [chemical binding]; other site
391165001031	Mg2+ binding site [ion binding]; other site
391165001032	G-X-G motif; other site
391165001033	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
391165001034	interface (dimer of trimers) [polypeptide binding]; other site
391165001035	Substrate-binding/catalytic site; other site
391165001036	Zn-binding sites [ion binding]; other site
391165001037	MarR family; Region: MarR; pfam01047
391165001038	DNA polymerase III subunit beta; Validated; Region: PRK05643
391165001039	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
391165001040	putative DNA binding surface [nucleotide binding]; other site
391165001041	dimer interface [polypeptide binding]; other site
391165001042	beta-clamp/clamp loader binding surface; other site
391165001043	beta-clamp/translesion DNA polymerase binding surface; other site
391165001044	recombination protein F; Reviewed; Region: recF; PRK00064
391165001045	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165001046	Walker A/P-loop; other site
391165001047	ATP binding site [chemical binding]; other site
391165001048	Q-loop/lid; other site
391165001049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165001050	ABC transporter signature motif; other site
391165001051	Walker B; other site
391165001052	D-loop; other site
391165001053	H-loop/switch region; other site
391165001054	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
391165001055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165001056	ATP binding site [chemical binding]; other site
391165001057	Mg2+ binding site [ion binding]; other site
391165001058	G-X-G motif; other site
391165001059	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
391165001060	anchoring element; other site
391165001061	dimer interface [polypeptide binding]; other site
391165001062	ATP binding site [chemical binding]; other site
391165001063	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
391165001064	active site
391165001065	putative metal-binding site [ion binding]; other site
391165001066	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
391165001067	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
391165001068	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
391165001069	active site
391165001070	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
391165001071	catalytic motif [active]
391165001072	Catalytic residue [active]
391165001073	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
391165001074	catalytic motif [active]
391165001075	Catalytic residue [active]
391165001076	DNA repair protein RadA; Provisional; Region: PRK11823
391165001077	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391165001078	Walker A motif; other site
391165001079	ATP binding site [chemical binding]; other site
391165001080	Walker B motif; other site
391165001081	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391165001082	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
391165001083	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165001084	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
391165001085	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
391165001086	putative active site [active]
391165001087	ATP-NAD kinase; Region: NAD_kinase; pfam01513
391165001088	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
391165001089	Predicted amidohydrolase [General function prediction only]; Region: COG0388
391165001090	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
391165001091	putative active site [active]
391165001092	catalytic triad [active]
391165001093	dimer interface [polypeptide binding]; other site
391165001094	OpgC protein; Region: OpgC_C; pfam10129
391165001095	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391165001096	active site
391165001097	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
391165001098	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
391165001099	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
391165001100	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
391165001101	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
391165001102	putative hydrophobic ligand binding site [chemical binding]; other site
391165001103	protein interface [polypeptide binding]; other site
391165001104	gate; other site
391165001105	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
391165001106	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
391165001107	Trp docking motif [polypeptide binding]; other site
391165001108	dimer interface [polypeptide binding]; other site
391165001109	active site
391165001110	small subunit binding site [polypeptide binding]; other site
391165001111	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
391165001112	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391165001113	substrate binding pocket [chemical binding]; other site
391165001114	membrane-bound complex binding site; other site
391165001115	hinge residues; other site
391165001116	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
391165001117	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
391165001118	MoxR-like ATPases [General function prediction only]; Region: COG0714
391165001119	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165001120	Walker A motif; other site
391165001121	ATP binding site [chemical binding]; other site
391165001122	Walker B motif; other site
391165001123	arginine finger; other site
391165001124	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
391165001125	metal ion-dependent adhesion site (MIDAS); other site
391165001126	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
391165001127	metal ion-dependent adhesion site (MIDAS); other site
391165001128	von Willebrand factor type A domain; Region: VWA_2; pfam13519
391165001129	HAMP domain; Region: HAMP; pfam00672
391165001130	dimerization interface [polypeptide binding]; other site
391165001131	Histidine kinase; Region: HisKA_3; pfam07730
391165001132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165001133	ATP binding site [chemical binding]; other site
391165001134	Mg2+ binding site [ion binding]; other site
391165001135	G-X-G motif; other site
391165001136	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391165001137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165001138	active site
391165001139	phosphorylation site [posttranslational modification]
391165001140	intermolecular recognition site; other site
391165001141	dimerization interface [polypeptide binding]; other site
391165001142	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
391165001143	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
391165001144	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
391165001145	Substrate binding site; other site
391165001146	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
391165001147	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
391165001148	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
391165001149	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
391165001150	ligand binding site [chemical binding]; other site
391165001151	Uncharacterized conserved protein [Function unknown]; Region: COG2308
391165001152	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
391165001153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
391165001154	pyruvate kinase; Provisional; Region: PRK06247
391165001155	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
391165001156	domain interfaces; other site
391165001157	active site
391165001158	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
391165001159	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
391165001160	MOFRL family; Region: MOFRL; pfam05161
391165001161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
391165001162	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
391165001163	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
391165001164	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
391165001165	active site
391165001166	Zn binding site [ion binding]; other site
391165001167	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
391165001168	ABC1 family; Region: ABC1; cl17513
391165001169	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
391165001170	ATP binding site [chemical binding]; other site
391165001171	activation loop (A-loop); other site
391165001172	Transglycosylase; Region: Transgly; pfam00912
391165001173	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
391165001174	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
391165001175	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
391165001176	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
391165001177	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
391165001178	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391165001179	dimerization interface [polypeptide binding]; other site
391165001180	putative DNA binding site [nucleotide binding]; other site
391165001181	putative Zn2+ binding site [ion binding]; other site
391165001182	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
391165001183	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
391165001184	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
391165001185	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
391165001186	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
391165001187	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
391165001188	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
391165001189	catalytic residues [active]
391165001190	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
391165001191	aspartate aminotransferase; Provisional; Region: PRK05764
391165001192	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391165001193	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165001194	homodimer interface [polypeptide binding]; other site
391165001195	catalytic residue [active]
391165001196	Flavin Reductases; Region: FlaRed; cl00801
391165001197	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
391165001198	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
391165001199	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391165001200	protein binding site [polypeptide binding]; other site
391165001201	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391165001202	protein binding site [polypeptide binding]; other site
391165001203	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
391165001204	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
391165001205	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165001206	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165001207	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
391165001208	dimerization interface [polypeptide binding]; other site
391165001209	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
391165001210	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
391165001211	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
391165001212	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391165001213	Coenzyme A binding pocket [chemical binding]; other site
391165001214	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
391165001215	CPxP  motif; other site
391165001216	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
391165001217	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
391165001218	metal binding site 2 [ion binding]; metal-binding site
391165001219	putative DNA binding helix; other site
391165001220	metal binding site 1 [ion binding]; metal-binding site
391165001221	dimer interface [polypeptide binding]; other site
391165001222	structural Zn2+ binding site [ion binding]; other site
391165001223	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
391165001224	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
391165001225	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
391165001226	putative active site [active]
391165001227	catalytic triad [active]
391165001228	putative dimer interface [polypeptide binding]; other site
391165001229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165001230	non-specific DNA binding site [nucleotide binding]; other site
391165001231	salt bridge; other site
391165001232	sequence-specific DNA binding site [nucleotide binding]; other site
391165001233	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
391165001234	Hpr binding site; other site
391165001235	active site
391165001236	homohexamer subunit interaction site [polypeptide binding]; other site
391165001237	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
391165001238	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
391165001239	active pocket/dimerization site; other site
391165001240	active site
391165001241	phosphorylation site [posttranslational modification]
391165001242	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
391165001243	dimerization domain swap beta strand [polypeptide binding]; other site
391165001244	regulatory protein interface [polypeptide binding]; other site
391165001245	active site
391165001246	regulatory phosphorylation site [posttranslational modification]; other site
391165001247	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
391165001248	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
391165001249	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
391165001250	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
391165001251	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
391165001252	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
391165001253	substrate binding site [chemical binding]; other site
391165001254	ATP binding site [chemical binding]; other site
391165001255	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
391165001256	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
391165001257	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
391165001258	aconitate hydratase; Validated; Region: PRK09277
391165001259	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
391165001260	substrate binding site [chemical binding]; other site
391165001261	ligand binding site [chemical binding]; other site
391165001262	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
391165001263	substrate binding site [chemical binding]; other site
391165001264	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
391165001265	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165001266	Walker A/P-loop; other site
391165001267	ATP binding site [chemical binding]; other site
391165001268	Q-loop/lid; other site
391165001269	ABC transporter signature motif; other site
391165001270	Walker B; other site
391165001271	D-loop; other site
391165001272	H-loop/switch region; other site
391165001273	CcmB protein; Region: CcmB; pfam03379
391165001274	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
391165001275	Domain of unknown function DUF20; Region: UPF0118; pfam01594
391165001276	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
391165001277	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
391165001278	active site
391165001279	P-loop; other site
391165001280	phosphorylation site [posttranslational modification]
391165001281	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
391165001282	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
391165001283	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
391165001284	putative substrate binding site [chemical binding]; other site
391165001285	putative ATP binding site [chemical binding]; other site
391165001286	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
391165001287	active site
391165001288	phosphorylation site [posttranslational modification]
391165001289	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
391165001290	dimerization domain swap beta strand [polypeptide binding]; other site
391165001291	regulatory protein interface [polypeptide binding]; other site
391165001292	active site
391165001293	regulatory phosphorylation site [posttranslational modification]; other site
391165001294	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
391165001295	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
391165001296	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
391165001297	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
391165001298	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391165001299	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391165001300	DNA binding site [nucleotide binding]
391165001301	domain linker motif; other site
391165001302	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
391165001303	putative dimerization interface [polypeptide binding]; other site
391165001304	putative ligand binding site [chemical binding]; other site
391165001305	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
391165001306	active site
391165001307	PII uridylyl-transferase; Provisional; Region: PRK05092
391165001308	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391165001309	metal binding triad; other site
391165001310	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
391165001311	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
391165001312	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
391165001313	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
391165001314	MutS domain I; Region: MutS_I; pfam01624
391165001315	MutS domain II; Region: MutS_II; pfam05188
391165001316	MutS domain III; Region: MutS_III; pfam05192
391165001317	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
391165001318	Walker A/P-loop; other site
391165001319	ATP binding site [chemical binding]; other site
391165001320	Q-loop/lid; other site
391165001321	ABC transporter signature motif; other site
391165001322	Walker B; other site
391165001323	D-loop; other site
391165001324	H-loop/switch region; other site
391165001325	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
391165001326	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
391165001327	active site
391165001328	catalytic site [active]
391165001329	tetramer interface [polypeptide binding]; other site
391165001330	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
391165001331	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
391165001332	nucleotide binding pocket [chemical binding]; other site
391165001333	K-X-D-G motif; other site
391165001334	catalytic site [active]
391165001335	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
391165001336	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
391165001337	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
391165001338	Dimer interface [polypeptide binding]; other site
391165001339	BRCT sequence motif; other site
391165001340	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
391165001341	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
391165001342	Walker A/P-loop; other site
391165001343	ATP binding site [chemical binding]; other site
391165001344	Q-loop/lid; other site
391165001345	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
391165001346	ABC transporter signature motif; other site
391165001347	Walker B; other site
391165001348	D-loop; other site
391165001349	H-loop/switch region; other site
391165001350	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
391165001351	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
391165001352	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
391165001353	cell division protein FtsZ; Validated; Region: PRK09330
391165001354	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
391165001355	nucleotide binding site [chemical binding]; other site
391165001356	SulA interaction site; other site
391165001357	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
391165001358	Cell division protein FtsA; Region: FtsA; smart00842
391165001359	cell division protein FtsA; Region: ftsA; TIGR01174
391165001360	Cell division protein FtsA; Region: FtsA; pfam14450
391165001361	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
391165001362	Cell division protein FtsQ; Region: FtsQ; pfam03799
391165001363	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
391165001364	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
391165001365	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391165001366	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
391165001367	FAD binding domain; Region: FAD_binding_4; pfam01565
391165001368	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
391165001369	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
391165001370	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391165001371	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391165001372	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
391165001373	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
391165001374	active site
391165001375	homodimer interface [polypeptide binding]; other site
391165001376	cell division protein FtsW; Region: ftsW; TIGR02614
391165001377	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
391165001378	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826
391165001379	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391165001380	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
391165001381	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
391165001382	Mg++ binding site [ion binding]; other site
391165001383	putative catalytic motif [active]
391165001384	putative substrate binding site [chemical binding]; other site
391165001385	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
391165001386	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391165001387	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391165001388	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391165001389	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
391165001390	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391165001391	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391165001392	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391165001393	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
391165001394	MraW methylase family; Region: Methyltransf_5; cl17771
391165001395	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
391165001396	cell division protein MraZ; Reviewed; Region: PRK00326
391165001397	MraZ protein; Region: MraZ; pfam02381
391165001398	MraZ protein; Region: MraZ; pfam02381
391165001399	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
391165001400	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
391165001401	amidase catalytic site [active]
391165001402	Zn binding residues [ion binding]; other site
391165001403	substrate binding site [chemical binding]; other site
391165001404	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
391165001405	putative metal binding site [ion binding]; other site
391165001406	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
391165001407	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
391165001408	putative active site [active]
391165001409	Methyltransferase domain; Region: Methyltransf_31; pfam13847
391165001410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165001411	S-adenosylmethionine binding site [chemical binding]; other site
391165001412	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
391165001413	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
391165001414	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165001415	FeS/SAM binding site; other site
391165001416	putative acyltransferase; Provisional; Region: PRK05790
391165001417	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
391165001418	dimer interface [polypeptide binding]; other site
391165001419	active site
391165001420	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
391165001421	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
391165001422	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
391165001423	ligand binding site [chemical binding]; other site
391165001424	flexible hinge region; other site
391165001425	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
391165001426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165001427	NAD(P) binding site [chemical binding]; other site
391165001428	active site
391165001429	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
391165001430	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
391165001431	putative glutathione S-transferase; Provisional; Region: PRK10357
391165001432	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
391165001433	putative C-terminal domain interface [polypeptide binding]; other site
391165001434	putative GSH binding site (G-site) [chemical binding]; other site
391165001435	putative dimer interface [polypeptide binding]; other site
391165001436	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
391165001437	dimer interface [polypeptide binding]; other site
391165001438	N-terminal domain interface [polypeptide binding]; other site
391165001439	putative substrate binding pocket (H-site) [chemical binding]; other site
391165001440	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
391165001441	Methyltransferase domain; Region: Methyltransf_11; pfam08241
391165001442	Methyltransferase domain; Region: Methyltransf_23; pfam13489
391165001443	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391165001444	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
391165001445	nucleoside/Zn binding site; other site
391165001446	dimer interface [polypeptide binding]; other site
391165001447	catalytic motif [active]
391165001448	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
391165001449	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
391165001450	catalytic triad [active]
391165001451	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
391165001452	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391165001453	RNA binding surface [nucleotide binding]; other site
391165001454	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
391165001455	active site
391165001456	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
391165001457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165001458	S-adenosylmethionine binding site [chemical binding]; other site
391165001459	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
391165001460	dimer interface [polypeptide binding]; other site
391165001461	putative tRNA-binding site [nucleotide binding]; other site
391165001462	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
391165001463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165001464	ATP binding site [chemical binding]; other site
391165001465	Mg2+ binding site [ion binding]; other site
391165001466	G-X-G motif; other site
391165001467	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
391165001468	ATP binding site [chemical binding]; other site
391165001469	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
391165001470	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
391165001471	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
391165001472	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
391165001473	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391165001474	active site
391165001475	HIGH motif; other site
391165001476	nucleotide binding site [chemical binding]; other site
391165001477	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
391165001478	active site
391165001479	KMSKS motif; other site
391165001480	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
391165001481	tRNA binding surface [nucleotide binding]; other site
391165001482	anticodon binding site; other site
391165001483	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
391165001484	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
391165001485	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
391165001486	active site
391165001487	Riboflavin kinase; Region: Flavokinase; smart00904
391165001488	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
391165001489	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
391165001490	active site
391165001491	Zn binding site [ion binding]; other site
391165001492	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
391165001493	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
391165001494	active site
391165001495	amidophosphoribosyltransferase; Provisional; Region: PRK09123
391165001496	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
391165001497	active site
391165001498	tetramer interface [polypeptide binding]; other site
391165001499	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391165001500	active site
391165001501	Colicin V production protein; Region: Colicin_V; pfam02674
391165001502	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
391165001503	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
391165001504	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
391165001505	PhoU domain; Region: PhoU; pfam01895
391165001506	septum formation inhibitor; Reviewed; Region: minC; PRK05177
391165001507	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
391165001508	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
391165001509	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
391165001510	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
391165001511	Switch I; other site
391165001512	Switch II; other site
391165001513	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
391165001514	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
391165001515	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165001516	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
391165001517	putative ADP-binding pocket [chemical binding]; other site
391165001518	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391165001519	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391165001520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165001521	Walker A/P-loop; other site
391165001522	ATP binding site [chemical binding]; other site
391165001523	Q-loop/lid; other site
391165001524	ABC transporter signature motif; other site
391165001525	Walker B; other site
391165001526	D-loop; other site
391165001527	H-loop/switch region; other site
391165001528	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
391165001529	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391165001530	active site
391165001531	catalytic residues [active]
391165001532	metal binding site [ion binding]; metal-binding site
391165001533	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
391165001534	COQ9; Region: COQ9; pfam08511
391165001535	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391165001536	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
391165001537	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391165001538	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
391165001539	isocitrate lyase; Provisional; Region: PRK15063
391165001540	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
391165001541	tetramer interface [polypeptide binding]; other site
391165001542	active site
391165001543	Mg2+/Mn2+ binding site [ion binding]; other site
391165001544	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391165001545	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165001546	non-specific DNA binding site [nucleotide binding]; other site
391165001547	salt bridge; other site
391165001548	sequence-specific DNA binding site [nucleotide binding]; other site
391165001549	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
391165001550	Domain of unknown function (DUF955); Region: DUF955; pfam06114
391165001551	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
391165001552	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
391165001553	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
391165001554	[2Fe-2S] cluster binding site [ion binding]; other site
391165001555	OPT oligopeptide transporter protein; Region: OPT; cl14607
391165001556	OPT oligopeptide transporter protein; Region: OPT; cl14607
391165001557	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
391165001558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391165001559	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
391165001560	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
391165001561	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
391165001562	Phosphopantetheine attachment site; Region: PP-binding; cl09936
391165001563	AAA domain; Region: AAA_26; pfam13500
391165001564	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
391165001565	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
391165001566	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
391165001567	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391165001568	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391165001569	catalytic residue [active]
391165001570	biotin synthase; Region: bioB; TIGR00433
391165001571	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165001572	FeS/SAM binding site; other site
391165001573	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
391165001574	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
391165001575	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
391165001576	inhibitor-cofactor binding pocket; inhibition site
391165001577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165001578	catalytic residue [active]
391165001579	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
391165001580	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391165001581	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
391165001582	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
391165001583	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
391165001584	tandem repeat interface [polypeptide binding]; other site
391165001585	oligomer interface [polypeptide binding]; other site
391165001586	active site residues [active]
391165001587	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
391165001588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165001589	active site
391165001590	phosphorylation site [posttranslational modification]
391165001591	intermolecular recognition site; other site
391165001592	dimerization interface [polypeptide binding]; other site
391165001593	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
391165001594	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391165001595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
391165001596	dimer interface [polypeptide binding]; other site
391165001597	phosphorylation site [posttranslational modification]
391165001598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165001599	ATP binding site [chemical binding]; other site
391165001600	Mg2+ binding site [ion binding]; other site
391165001601	G-X-G motif; other site
391165001602	SpoVR family protein; Provisional; Region: PRK11767
391165001603	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
391165001604	hypothetical protein; Provisional; Region: PRK05325
391165001605	PrkA family serine protein kinase; Provisional; Region: PRK15455
391165001606	AAA ATPase domain; Region: AAA_16; pfam13191
391165001607	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
391165001608	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
391165001609	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
391165001610	homodimer interface [polypeptide binding]; other site
391165001611	substrate-cofactor binding pocket; other site
391165001612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165001613	catalytic residue [active]
391165001614	Gram-negative porin; Region: Porin_4; pfam13609
391165001615	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
391165001616	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
391165001617	putative ribose interaction site [chemical binding]; other site
391165001618	putative ADP binding site [chemical binding]; other site
391165001619	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
391165001620	active site
391165001621	HIGH motif; other site
391165001622	nucleotide binding site [chemical binding]; other site
391165001623	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
391165001624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165001625	S-adenosylmethionine binding site [chemical binding]; other site
391165001626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391165001627	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
391165001628	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391165001629	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391165001630	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
391165001631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
391165001632	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
391165001633	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
391165001634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
391165001635	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391165001636	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
391165001637	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391165001638	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
391165001639	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
391165001640	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
391165001641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165001642	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
391165001643	active site
391165001644	phosphorylation site [posttranslational modification]
391165001645	intermolecular recognition site; other site
391165001646	ornithine decarboxylase; Provisional; Region: PRK13578
391165001647	dimerization interface [polypeptide binding]; other site
391165001648	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391165001649	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391165001650	catalytic residue [active]
391165001651	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
391165001652	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
391165001653	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
391165001654	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
391165001655	Domain of unknown function (DUF336); Region: DUF336; cl01249
391165001656	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
391165001657	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
391165001658	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391165001659	RNA binding surface [nucleotide binding]; other site
391165001660	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
391165001661	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
391165001662	G1 box; other site
391165001663	putative GEF interaction site [polypeptide binding]; other site
391165001664	GTP/Mg2+ binding site [chemical binding]; other site
391165001665	Switch I region; other site
391165001666	G2 box; other site
391165001667	G3 box; other site
391165001668	Switch II region; other site
391165001669	G4 box; other site
391165001670	G5 box; other site
391165001671	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
391165001672	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
391165001673	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
391165001674	Active Sites [active]
391165001675	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391165001676	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391165001677	active site
391165001678	catalytic tetrad [active]
391165001679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
391165001680	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
391165001681	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
391165001682	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
391165001683	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391165001684	DEAD-like helicases superfamily; Region: DEXDc; smart00487
391165001685	ATP binding site [chemical binding]; other site
391165001686	putative Mg++ binding site [ion binding]; other site
391165001687	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165001688	nucleotide binding region [chemical binding]; other site
391165001689	ATP-binding site [chemical binding]; other site
391165001690	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
391165001691	RNA binding site [nucleotide binding]; other site
391165001692	manganese transport regulator MntR; Provisional; Region: PRK11050
391165001693	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
391165001694	DNA binding site [nucleotide binding]
391165001695	sequence specific DNA binding site [nucleotide binding]; other site
391165001696	putative cAMP binding site [chemical binding]; other site
391165001697	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
391165001698	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165001699	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
391165001700	putative ADP-binding pocket [chemical binding]; other site
391165001701	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391165001702	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391165001703	nucleotide binding site [chemical binding]; other site
391165001704	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
391165001705	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
391165001706	Walker A/P-loop; other site
391165001707	ATP binding site [chemical binding]; other site
391165001708	Q-loop/lid; other site
391165001709	ABC transporter signature motif; other site
391165001710	Walker B; other site
391165001711	D-loop; other site
391165001712	H-loop/switch region; other site
391165001713	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
391165001714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165001715	dimer interface [polypeptide binding]; other site
391165001716	conserved gate region; other site
391165001717	putative PBP binding loops; other site
391165001718	ABC-ATPase subunit interface; other site
391165001719	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
391165001720	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391165001721	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
391165001722	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
391165001723	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
391165001724	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
391165001725	23S rRNA interface [nucleotide binding]; other site
391165001726	L7/L12 interface [polypeptide binding]; other site
391165001727	putative thiostrepton binding site; other site
391165001728	L25 interface [polypeptide binding]; other site
391165001729	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
391165001730	mRNA/rRNA interface [nucleotide binding]; other site
391165001731	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
391165001732	23S rRNA interface [nucleotide binding]; other site
391165001733	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
391165001734	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
391165001735	L11 interface [polypeptide binding]; other site
391165001736	putative EF-Tu interaction site [polypeptide binding]; other site
391165001737	putative EF-G interaction site [polypeptide binding]; other site
391165001738	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
391165001739	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
391165001740	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
391165001741	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
391165001742	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
391165001743	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
391165001744	RPB1 interaction site [polypeptide binding]; other site
391165001745	RPB11 interaction site [polypeptide binding]; other site
391165001746	RPB10 interaction site [polypeptide binding]; other site
391165001747	RPB3 interaction site [polypeptide binding]; other site
391165001748	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
391165001749	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
391165001750	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
391165001751	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
391165001752	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
391165001753	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
391165001754	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
391165001755	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
391165001756	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
391165001757	DNA binding site [nucleotide binding]
391165001758	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
391165001759	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
391165001760	S17 interaction site [polypeptide binding]; other site
391165001761	S8 interaction site; other site
391165001762	16S rRNA interaction site [nucleotide binding]; other site
391165001763	streptomycin interaction site [chemical binding]; other site
391165001764	23S rRNA interaction site [nucleotide binding]; other site
391165001765	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
391165001766	30S ribosomal protein S7; Validated; Region: PRK05302
391165001767	elongation factor Tu; Reviewed; Region: PRK00049
391165001768	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
391165001769	G1 box; other site
391165001770	GEF interaction site [polypeptide binding]; other site
391165001771	GTP/Mg2+ binding site [chemical binding]; other site
391165001772	Switch I region; other site
391165001773	G2 box; other site
391165001774	G3 box; other site
391165001775	Switch II region; other site
391165001776	G4 box; other site
391165001777	G5 box; other site
391165001778	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
391165001779	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
391165001780	Antibiotic Binding Site [chemical binding]; other site
391165001781	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
391165001782	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
391165001783	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
391165001784	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
391165001785	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
391165001786	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
391165001787	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
391165001788	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
391165001789	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
391165001790	putative translocon binding site; other site
391165001791	protein-rRNA interface [nucleotide binding]; other site
391165001792	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
391165001793	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
391165001794	G-X-X-G motif; other site
391165001795	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
391165001796	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
391165001797	5S rRNA interface [nucleotide binding]; other site
391165001798	23S rRNA interface [nucleotide binding]; other site
391165001799	putative antibiotic binding site [chemical binding]; other site
391165001800	L25 interface [polypeptide binding]; other site
391165001801	L27 interface [polypeptide binding]; other site
391165001802	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
391165001803	23S rRNA interface [nucleotide binding]; other site
391165001804	putative translocon interaction site; other site
391165001805	signal recognition particle (SRP54) interaction site; other site
391165001806	L23 interface [polypeptide binding]; other site
391165001807	trigger factor interaction site; other site
391165001808	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
391165001809	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
391165001810	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
391165001811	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
391165001812	RNA binding site [nucleotide binding]; other site
391165001813	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
391165001814	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
391165001815	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
391165001816	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
391165001817	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
391165001818	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
391165001819	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
391165001820	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
391165001821	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
391165001822	23S rRNA interface [nucleotide binding]; other site
391165001823	L21e interface [polypeptide binding]; other site
391165001824	5S rRNA interface [nucleotide binding]; other site
391165001825	L27 interface [polypeptide binding]; other site
391165001826	L5 interface [polypeptide binding]; other site
391165001827	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
391165001828	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
391165001829	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
391165001830	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
391165001831	23S rRNA binding site [nucleotide binding]; other site
391165001832	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
391165001833	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
391165001834	SecY translocase; Region: SecY; pfam00344
391165001835	adenylate kinase; Reviewed; Region: adk; PRK00279
391165001836	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
391165001837	AMP-binding site [chemical binding]; other site
391165001838	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
391165001839	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
391165001840	30S ribosomal protein S13; Region: bact_S13; TIGR03631
391165001841	30S ribosomal protein S11; Validated; Region: PRK05309
391165001842	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
391165001843	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
391165001844	alphaNTD - beta interaction site [polypeptide binding]; other site
391165001845	alphaNTD homodimer interface [polypeptide binding]; other site
391165001846	alphaNTD - beta' interaction site [polypeptide binding]; other site
391165001847	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
391165001848	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
391165001849	Predicted permeases [General function prediction only]; Region: COG0679
391165001850	recombination factor protein RarA; Reviewed; Region: PRK13342
391165001851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165001852	Walker A motif; other site
391165001853	ATP binding site [chemical binding]; other site
391165001854	Walker B motif; other site
391165001855	arginine finger; other site
391165001856	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
391165001857	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
391165001858	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391165001859	RNA binding surface [nucleotide binding]; other site
391165001860	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
391165001861	active site
391165001862	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
391165001863	ATP12 chaperone protein; Region: ATP12; pfam07542
391165001864	Acylphosphatase; Region: Acylphosphatase; pfam00708
391165001865	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
391165001866	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
391165001867	lipoate-protein ligase B; Provisional; Region: PRK14341
391165001868	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
391165001869	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
391165001870	active site
391165001871	tetramer interface; other site
391165001872	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
391165001873	active site
391165001874	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
391165001875	substrate binding site [chemical binding]; other site
391165001876	metal binding site [ion binding]; metal-binding site
391165001877	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
391165001878	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
391165001879	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165001880	FeS/SAM binding site; other site
391165001881	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
391165001882	Methyltransferase domain; Region: Methyltransf_23; pfam13489
391165001883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165001884	S-adenosylmethionine binding site [chemical binding]; other site
391165001885	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391165001886	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165001887	non-specific DNA binding site [nucleotide binding]; other site
391165001888	salt bridge; other site
391165001889	sequence-specific DNA binding site [nucleotide binding]; other site
391165001890	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
391165001891	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391165001892	active site
391165001893	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
391165001894	GSH binding site [chemical binding]; other site
391165001895	catalytic residues [active]
391165001896	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
391165001897	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
391165001898	Methyltransferase domain; Region: Methyltransf_11; pfam08241
391165001899	S-adenosylmethionine binding site [chemical binding]; other site
391165001900	aspartate kinase; Reviewed; Region: PRK06635
391165001901	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
391165001902	putative nucleotide binding site [chemical binding]; other site
391165001903	putative catalytic residues [active]
391165001904	putative Mg ion binding site [ion binding]; other site
391165001905	putative aspartate binding site [chemical binding]; other site
391165001906	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
391165001907	putative allosteric regulatory site; other site
391165001908	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
391165001909	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
391165001910	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
391165001911	FMN binding site [chemical binding]; other site
391165001912	substrate binding site [chemical binding]; other site
391165001913	putative catalytic residue [active]
391165001914	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
391165001915	GAF domain; Region: GAF; pfam01590
391165001916	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
391165001917	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
391165001918	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
391165001919	Helix-turn-helix domain; Region: HTH_25; pfam13413
391165001920	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
391165001921	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
391165001922	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
391165001923	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
391165001924	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
391165001925	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
391165001926	dimer interface [polypeptide binding]; other site
391165001927	motif 1; other site
391165001928	active site
391165001929	motif 2; other site
391165001930	motif 3; other site
391165001931	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
391165001932	anticodon binding site; other site
391165001933	peptide chain release factor 1; Validated; Region: prfA; PRK00591
391165001934	This domain is found in peptide chain release factors; Region: PCRF; smart00937
391165001935	RF-1 domain; Region: RF-1; pfam00472
391165001936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165001937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391165001938	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
391165001939	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
391165001940	nudix motif; other site
391165001941	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391165001942	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
391165001943	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
391165001944	Walker A/P-loop; other site
391165001945	ATP binding site [chemical binding]; other site
391165001946	Q-loop/lid; other site
391165001947	ABC transporter signature motif; other site
391165001948	Walker B; other site
391165001949	D-loop; other site
391165001950	H-loop/switch region; other site
391165001951	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
391165001952	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
391165001953	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
391165001954	ADP binding site [chemical binding]; other site
391165001955	magnesium binding site [ion binding]; other site
391165001956	putative shikimate binding site; other site
391165001957	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
391165001958	active site
391165001959	dimer interface [polypeptide binding]; other site
391165001960	metal binding site [ion binding]; metal-binding site
391165001961	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
391165001962	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391165001963	active site
391165001964	DNA binding site [nucleotide binding]
391165001965	Int/Topo IB signature motif; other site
391165001966	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
391165001967	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
391165001968	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
391165001969	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
391165001970	N-terminal plug; other site
391165001971	ligand-binding site [chemical binding]; other site
391165001972	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
391165001973	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
391165001974	DEAD/DEAH box helicase; Region: DEAD; pfam00270
391165001975	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
391165001976	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
391165001977	nucleotide binding region [chemical binding]; other site
391165001978	ATP-binding site [chemical binding]; other site
391165001979	SEC-C motif; Region: SEC-C; pfam02810
391165001980	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
391165001981	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
391165001982	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
391165001983	heterotetramer interface [polypeptide binding]; other site
391165001984	active site pocket [active]
391165001985	cleavage site
391165001986	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391165001987	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
391165001988	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
391165001989	active site
391165001990	8-oxo-dGMP binding site [chemical binding]; other site
391165001991	nudix motif; other site
391165001992	metal binding site [ion binding]; metal-binding site
391165001993	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
391165001994	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
391165001995	putative MPT binding site; other site
391165001996	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
391165001997	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
391165001998	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391165001999	HSP70 interaction site [polypeptide binding]; other site
391165002000	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
391165002001	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
391165002002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
391165002003	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
391165002004	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
391165002005	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
391165002006	metal ion-dependent adhesion site (MIDAS); other site
391165002007	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910
391165002008	putative active site [active]
391165002009	Zn binding site [ion binding]; other site
391165002010	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
391165002011	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
391165002012	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391165002013	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
391165002014	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
391165002015	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
391165002016	quinolinate synthetase; Provisional; Region: PRK09375
391165002017	L-aspartate oxidase; Provisional; Region: PRK07512
391165002018	L-aspartate oxidase; Provisional; Region: PRK06175
391165002019	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
391165002020	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
391165002021	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
391165002022	dimerization interface [polypeptide binding]; other site
391165002023	active site
391165002024	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
391165002025	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
391165002026	active site
391165002027	dimer interface [polypeptide binding]; other site
391165002028	non-prolyl cis peptide bond; other site
391165002029	insertion regions; other site
391165002030	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
391165002031	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
391165002032	Flavin binding site [chemical binding]; other site
391165002033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
391165002034	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
391165002035	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
391165002036	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
391165002037	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391165002038	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
391165002039	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165002040	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
391165002041	putative ADP-binding pocket [chemical binding]; other site
391165002042	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
391165002043	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
391165002044	Trp docking motif [polypeptide binding]; other site
391165002045	dimer interface [polypeptide binding]; other site
391165002046	active site
391165002047	small subunit binding site [polypeptide binding]; other site
391165002048	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
391165002049	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391165002050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165002051	homodimer interface [polypeptide binding]; other site
391165002052	catalytic residue [active]
391165002053	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
391165002054	cobyric acid synthase; Provisional; Region: PRK00784
391165002055	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391165002056	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391165002057	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
391165002058	catalytic triad [active]
391165002059	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
391165002060	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
391165002061	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
391165002062	homodimer interface [polypeptide binding]; other site
391165002063	Walker A motif; other site
391165002064	ATP binding site [chemical binding]; other site
391165002065	hydroxycobalamin binding site [chemical binding]; other site
391165002066	Walker B motif; other site
391165002067	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
391165002068	homotrimer interface [polypeptide binding]; other site
391165002069	Walker A motif; other site
391165002070	GTP binding site [chemical binding]; other site
391165002071	Walker B motif; other site
391165002072	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
391165002073	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
391165002074	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
391165002075	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
391165002076	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
391165002077	precorrin-3B synthase; Region: CobG; TIGR02435
391165002078	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
391165002079	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
391165002080	Precorrin-8X methylmutase; Region: CbiC; pfam02570
391165002081	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
391165002082	active site
391165002083	SAM binding site [chemical binding]; other site
391165002084	homodimer interface [polypeptide binding]; other site
391165002085	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
391165002086	active site
391165002087	SAM binding site [chemical binding]; other site
391165002088	homodimer interface [polypeptide binding]; other site
391165002089	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
391165002090	active site
391165002091	putative homodimer interface [polypeptide binding]; other site
391165002092	SAM binding site [chemical binding]; other site
391165002093	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
391165002094	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165002095	S-adenosylmethionine binding site [chemical binding]; other site
391165002096	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
391165002097	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
391165002098	active site
391165002099	SAM binding site [chemical binding]; other site
391165002100	homodimer interface [polypeptide binding]; other site
391165002101	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
391165002102	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
391165002103	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
391165002104	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
391165002105	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
391165002106	iron-sulfur cluster [ion binding]; other site
391165002107	[2Fe-2S] cluster binding site [ion binding]; other site
391165002108	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
391165002109	hydrophobic ligand binding site; other site
391165002110	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
391165002111	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
391165002112	putative dimer interface [polypeptide binding]; other site
391165002113	active site pocket [active]
391165002114	putative cataytic base [active]
391165002115	cobalamin synthase; Reviewed; Region: cobS; PRK00235
391165002116	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
391165002117	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
391165002118	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165002119	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391165002120	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391165002121	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
391165002122	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
391165002123	aminopeptidase N; Provisional; Region: pepN; PRK14015
391165002124	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
391165002125	active site
391165002126	Zn binding site [ion binding]; other site
391165002127	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
391165002128	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
391165002129	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
391165002130	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
391165002131	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
391165002132	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
391165002133	dimer interface [polypeptide binding]; other site
391165002134	decamer (pentamer of dimers) interface [polypeptide binding]; other site
391165002135	catalytic triad [active]
391165002136	peroxidatic and resolving cysteines [active]
391165002137	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165002138	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165002139	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
391165002140	dimerization interface [polypeptide binding]; other site
391165002141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165002142	TPR motif; other site
391165002143	binding surface
391165002144	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391165002145	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
391165002146	IHF - DNA interface [nucleotide binding]; other site
391165002147	IHF dimer interface [polypeptide binding]; other site
391165002148	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
391165002149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165002150	Mg2+ binding site [ion binding]; other site
391165002151	G-X-G motif; other site
391165002152	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
391165002153	anchoring element; other site
391165002154	dimer interface [polypeptide binding]; other site
391165002155	ATP binding site [chemical binding]; other site
391165002156	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
391165002157	active site
391165002158	putative metal-binding site [ion binding]; other site
391165002159	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
391165002160	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
391165002161	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
391165002162	dimerization interface [polypeptide binding]; other site
391165002163	DPS ferroxidase diiron center [ion binding]; other site
391165002164	ion pore; other site
391165002165	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
391165002166	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
391165002167	trimer interface [polypeptide binding]; other site
391165002168	active site
391165002169	substrate binding site [chemical binding]; other site
391165002170	CoA binding site [chemical binding]; other site
391165002171	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
391165002172	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
391165002173	metal binding site [ion binding]; metal-binding site
391165002174	dimer interface [polypeptide binding]; other site
391165002175	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
391165002176	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
391165002177	dimerization interface 3.5A [polypeptide binding]; other site
391165002178	active site
391165002179	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
391165002180	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
391165002181	putative active site [active]
391165002182	substrate binding site [chemical binding]; other site
391165002183	putative cosubstrate binding site; other site
391165002184	catalytic site [active]
391165002185	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
391165002186	substrate binding site [chemical binding]; other site
391165002187	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391165002188	active site
391165002189	catalytic residues [active]
391165002190	metal binding site [ion binding]; metal-binding site
391165002191	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
391165002192	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
391165002193	putative dimer interface [polypeptide binding]; other site
391165002194	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
391165002195	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
391165002196	30S subunit binding site; other site
391165002197	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
391165002198	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
391165002199	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
391165002200	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
391165002201	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
391165002202	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
391165002203	Walker A/P-loop; other site
391165002204	ATP binding site [chemical binding]; other site
391165002205	Q-loop/lid; other site
391165002206	ABC transporter signature motif; other site
391165002207	Walker B; other site
391165002208	D-loop; other site
391165002209	H-loop/switch region; other site
391165002210	OstA-like protein; Region: OstA; cl00844
391165002211	OstA-like protein; Region: OstA; cl00844
391165002212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
391165002213	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
391165002214	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
391165002215	putative active site [active]
391165002216	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
391165002217	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
391165002218	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
391165002219	catalytic site [active]
391165002220	putative active site [active]
391165002221	putative substrate binding site [chemical binding]; other site
391165002222	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
391165002223	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
391165002224	putative NAD(P) binding site [chemical binding]; other site
391165002225	active site
391165002226	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
391165002227	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391165002228	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165002229	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
391165002230	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
391165002231	active site
391165002232	dimer interface [polypeptide binding]; other site
391165002233	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
391165002234	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
391165002235	active site
391165002236	FMN binding site [chemical binding]; other site
391165002237	substrate binding site [chemical binding]; other site
391165002238	3Fe-4S cluster binding site [ion binding]; other site
391165002239	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
391165002240	domain interface; other site
391165002241	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
391165002242	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
391165002243	C-terminal domain interface [polypeptide binding]; other site
391165002244	GSH binding site (G-site) [chemical binding]; other site
391165002245	dimer interface [polypeptide binding]; other site
391165002246	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
391165002247	N-terminal domain interface [polypeptide binding]; other site
391165002248	dimer interface [polypeptide binding]; other site
391165002249	substrate binding pocket (H-site) [chemical binding]; other site
391165002250	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
391165002251	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165002252	binding surface
391165002253	TPR motif; other site
391165002254	TPR repeat; Region: TPR_11; pfam13414
391165002255	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
391165002256	NADH(P)-binding; Region: NAD_binding_10; pfam13460
391165002257	putative NAD(P) binding site [chemical binding]; other site
391165002258	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
391165002259	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391165002260	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
391165002261	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
391165002262	active site
391165002263	HIGH motif; other site
391165002264	nucleotide binding site [chemical binding]; other site
391165002265	active site
391165002266	KMSKS motif; other site
391165002267	putative hydrolase; Provisional; Region: PRK11460
391165002268	Predicted esterase [General function prediction only]; Region: COG0400
391165002269	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
391165002270	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
391165002271	active site
391165002272	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442
391165002273	Cytochrome c; Region: Cytochrom_C; cl11414
391165002274	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
391165002275	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
391165002276	diiron binding motif [ion binding]; other site
391165002277	aspartate aminotransferase; Provisional; Region: PRK05764
391165002278	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391165002279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165002280	homodimer interface [polypeptide binding]; other site
391165002281	catalytic residue [active]
391165002282	aspartate aminotransferase; Provisional; Region: PRK05764
391165002283	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391165002284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165002285	homodimer interface [polypeptide binding]; other site
391165002286	catalytic residue [active]
391165002287	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
391165002288	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
391165002289	Ligand binding site; other site
391165002290	Putative Catalytic site; other site
391165002291	DXD motif; other site
391165002292	tyrosine decarboxylase; Region: PLN02880
391165002293	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391165002294	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391165002295	catalytic residue [active]
391165002296	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165002297	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165002298	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
391165002299	putative effector binding pocket; other site
391165002300	dimerization interface [polypeptide binding]; other site
391165002301	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
391165002302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391165002303	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165002304	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
391165002305	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391165002306	putative DNA binding site [nucleotide binding]; other site
391165002307	putative Zn2+ binding site [ion binding]; other site
391165002308	AsnC family; Region: AsnC_trans_reg; pfam01037
391165002309	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
391165002310	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
391165002311	Ribonuclease P; Region: Ribonuclease_P; pfam00825
391165002312	Haemolytic domain; Region: Haemolytic; pfam01809
391165002313	membrane protein insertase; Provisional; Region: PRK01318
391165002314	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
391165002315	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
391165002316	G1 box; other site
391165002317	GTP/Mg2+ binding site [chemical binding]; other site
391165002318	Switch I region; other site
391165002319	G2 box; other site
391165002320	G3 box; other site
391165002321	Switch II region; other site
391165002322	G4 box; other site
391165002323	G5 box; other site
391165002324	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127
391165002325	PLD-like domain; Region: PLDc_2; pfam13091
391165002326	putative active site [active]
391165002327	putative catalytic site [active]
391165002328	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128
391165002329	PLD-like domain; Region: PLDc_2; pfam13091
391165002330	putative active site [active]
391165002331	putative catalytic site [active]
391165002332	Chromate transporter; Region: Chromate_transp; pfam02417
391165002333	Chromate transporter; Region: Chromate_transp; pfam02417
391165002334	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
391165002335	feedback inhibition sensing region; other site
391165002336	homohexameric interface [polypeptide binding]; other site
391165002337	nucleotide binding site [chemical binding]; other site
391165002338	N-acetyl-L-glutamate binding site [chemical binding]; other site
391165002339	siroheme synthase; Provisional; Region: cysG; PRK10637
391165002340	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
391165002341	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
391165002342	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
391165002343	active site
391165002344	SAM binding site [chemical binding]; other site
391165002345	homodimer interface [polypeptide binding]; other site
391165002346	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
391165002347	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165002348	NAD(P) binding site [chemical binding]; other site
391165002349	active site
391165002350	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165002351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165002352	active site
391165002353	phosphorylation site [posttranslational modification]
391165002354	intermolecular recognition site; other site
391165002355	dimerization interface [polypeptide binding]; other site
391165002356	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165002357	DNA binding site [nucleotide binding]
391165002358	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391165002359	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391165002360	dimerization interface [polypeptide binding]; other site
391165002361	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165002362	dimer interface [polypeptide binding]; other site
391165002363	phosphorylation site [posttranslational modification]
391165002364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165002365	ATP binding site [chemical binding]; other site
391165002366	Mg2+ binding site [ion binding]; other site
391165002367	G-X-G motif; other site
391165002368	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
391165002369	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
391165002370	homodimer interface [polypeptide binding]; other site
391165002371	substrate-cofactor binding pocket; other site
391165002372	catalytic residue [active]
391165002373	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
391165002374	Methyltransferase domain; Region: Methyltransf_23; pfam13489
391165002375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165002376	S-adenosylmethionine binding site [chemical binding]; other site
391165002377	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165002378	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391165002379	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391165002380	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391165002381	active site
391165002382	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391165002383	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
391165002384	Probable Catalytic site; other site
391165002385	metal-binding site
391165002386	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
391165002387	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391165002388	active site
391165002389	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391165002390	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
391165002391	Probable Catalytic site; other site
391165002392	metal-binding site
391165002393	ABC transporter ATPase component; Reviewed; Region: PRK11147
391165002394	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391165002395	ABC transporter; Region: ABC_tran_2; pfam12848
391165002396	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391165002397	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
391165002398	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
391165002399	active site
391165002400	homotetramer interface [polypeptide binding]; other site
391165002401	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
391165002402	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
391165002403	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
391165002404	active site
391165002405	catalytic site [active]
391165002406	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
391165002407	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
391165002408	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
391165002409	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
391165002410	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
391165002411	catalytic site [active]
391165002412	active site
391165002413	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
391165002414	glycogen branching enzyme; Provisional; Region: PRK05402
391165002415	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
391165002416	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
391165002417	active site
391165002418	catalytic site [active]
391165002419	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
391165002420	trehalose synthase; Region: treS_nterm; TIGR02456
391165002421	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
391165002422	active site
391165002423	catalytic site [active]
391165002424	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
391165002425	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
391165002426	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
391165002427	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
391165002428	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
391165002429	active site
391165002430	homodimer interface [polypeptide binding]; other site
391165002431	catalytic site [active]
391165002432	acceptor binding site [chemical binding]; other site
391165002433	Response regulator receiver domain; Region: Response_reg; pfam00072
391165002434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165002435	active site
391165002436	phosphorylation site [posttranslational modification]
391165002437	intermolecular recognition site; other site
391165002438	dimerization interface [polypeptide binding]; other site
391165002439	RNA polymerase sigma factor; Provisional; Region: PRK12547
391165002440	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391165002441	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391165002442	DNA binding residues [nucleotide binding]
391165002443	RNA polymerase sigma factor; Provisional; Region: PRK12546
391165002444	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391165002445	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391165002446	DNA binding residues [nucleotide binding]
391165002447	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
391165002448	Histidine kinase; Region: HisKA_2; pfam07568
391165002449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165002450	ATP binding site [chemical binding]; other site
391165002451	Mg2+ binding site [ion binding]; other site
391165002452	G-X-G motif; other site
391165002453	Pantoate-beta-alanine ligase; Region: PanC; cd00560
391165002454	pantoate--beta-alanine ligase; Region: panC; TIGR00018
391165002455	active site
391165002456	ATP-binding site [chemical binding]; other site
391165002457	pantoate-binding site; other site
391165002458	HXXH motif; other site
391165002459	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
391165002460	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
391165002461	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
391165002462	Glutamine amidotransferase class-I; Region: GATase; pfam00117
391165002463	glutamine binding [chemical binding]; other site
391165002464	catalytic triad [active]
391165002465	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
391165002466	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
391165002467	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
391165002468	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
391165002469	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
391165002470	homodimer interface [polypeptide binding]; other site
391165002471	substrate-cofactor binding pocket; other site
391165002472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165002473	catalytic residue [active]
391165002474	hypothetical protein; Provisional; Region: PRK02227
391165002475	Dihydroneopterin aldolase; Region: FolB; smart00905
391165002476	active site
391165002477	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
391165002478	nucleotide binding site [chemical binding]; other site
391165002479	substrate binding site [chemical binding]; other site
391165002480	Archaeal flavoproteins [Energy production and conversion]; Region: COG1036
391165002481	Flavoprotein; Region: Flavoprotein; pfam02441
391165002482	dihydropteroate synthase-related protein; Region: TIGR00284
391165002483	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
391165002484	substrate binding pocket [chemical binding]; other site
391165002485	dimer interface [polypeptide binding]; other site
391165002486	inhibitor binding site; inhibition site
391165002487	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
391165002488	Protein of unknown function (DUF447); Region: DUF447; pfam04289
391165002489	Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668
391165002490	hisA/hisF family protein; Region: hisAF_rel; TIGR00734
391165002491	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
391165002492	active site
391165002493	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
391165002494	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
391165002495	ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356
391165002496	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391165002497	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
391165002498	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
391165002499	trimer interface I [polypeptide binding]; other site
391165002500	putative substrate binding pocket [chemical binding]; other site
391165002501	trimer interface II [polypeptide binding]; other site
391165002502	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391165002503	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
391165002504	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
391165002505	NADP binding site [chemical binding]; other site
391165002506	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
391165002507	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
391165002508	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
391165002509	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
391165002510	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
391165002511	aromatic arch; other site
391165002512	DCoH dimer interaction site [polypeptide binding]; other site
391165002513	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
391165002514	DCoH tetramer interaction site [polypeptide binding]; other site
391165002515	substrate binding site [chemical binding]; other site
391165002516	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
391165002517	molybdopterin cofactor binding site; other site
391165002518	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
391165002519	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
391165002520	active site
391165002521	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
391165002522	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
391165002523	FTR, proximal lobe; Region: FTR_C; pfam02741
391165002524	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
391165002525	domain_subunit interface; other site
391165002526	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
391165002527	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
391165002528	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
391165002529	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
391165002530	THF binding site; other site
391165002531	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
391165002532	substrate binding site [chemical binding]; other site
391165002533	THF binding site; other site
391165002534	zinc-binding site [ion binding]; other site
391165002535	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
391165002536	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
391165002537	L-lactate permease; Region: Lactate_perm; cl00701
391165002538	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391165002539	active site
391165002540	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391165002541	catalytic tetrad [active]
391165002542	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
391165002543	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
391165002544	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
391165002545	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
391165002546	AMP-binding enzyme; Region: AMP-binding; pfam00501
391165002547	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
391165002548	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
391165002549	acyl-activating enzyme (AAE) consensus motif; other site
391165002550	acyl-activating enzyme (AAE) consensus motif; other site
391165002551	putative AMP binding site [chemical binding]; other site
391165002552	putative active site [active]
391165002553	putative CoA binding site [chemical binding]; other site
391165002554	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
391165002555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165002556	putative substrate translocation pore; other site
391165002557	Predicted membrane protein [Function unknown]; Region: COG1238
391165002558	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
391165002559	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391165002560	catalytic loop [active]
391165002561	iron binding site [ion binding]; other site
391165002562	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
391165002563	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
391165002564	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
391165002565	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
391165002566	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
391165002567	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
391165002568	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
391165002569	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
391165002570	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
391165002571	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
391165002572	active site
391165002573	catalytic residues [active]
391165002574	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
391165002575	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
391165002576	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
391165002577	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
391165002578	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
391165002579	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
391165002580	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
391165002581	C-terminal domain interface [polypeptide binding]; other site
391165002582	GSH binding site (G-site) [chemical binding]; other site
391165002583	dimer interface [polypeptide binding]; other site
391165002584	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
391165002585	N-terminal domain interface [polypeptide binding]; other site
391165002586	dimer interface [polypeptide binding]; other site
391165002587	substrate binding pocket (H-site) [chemical binding]; other site
391165002588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165002589	S-adenosylmethionine binding site [chemical binding]; other site
391165002590	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
391165002591	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
391165002592	protein binding site [polypeptide binding]; other site
391165002593	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
391165002594	Catalytic dyad [active]
391165002595	ribonuclease R; Region: RNase_R; TIGR02063
391165002596	RNB domain; Region: RNB; pfam00773
391165002597	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
391165002598	RNA binding site [nucleotide binding]; other site
391165002599	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
391165002600	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
391165002601	active site
391165002602	interdomain interaction site; other site
391165002603	putative metal-binding site [ion binding]; other site
391165002604	nucleotide binding site [chemical binding]; other site
391165002605	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
391165002606	domain I; other site
391165002607	DNA binding groove [nucleotide binding]
391165002608	phosphate binding site [ion binding]; other site
391165002609	domain II; other site
391165002610	domain III; other site
391165002611	nucleotide binding site [chemical binding]; other site
391165002612	catalytic site [active]
391165002613	domain IV; other site
391165002614	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
391165002615	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
391165002616	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
391165002617	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
391165002618	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
391165002619	DNA protecting protein DprA; Region: dprA; TIGR00732
391165002620	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
391165002621	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
391165002622	dihydroorotase; Validated; Region: pyrC; PRK09357
391165002623	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
391165002624	active site
391165002625	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
391165002626	catalytic triad [active]
391165002627	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
391165002628	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
391165002629	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
391165002630	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165002631	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165002632	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
391165002633	putative effector binding pocket; other site
391165002634	dimerization interface [polypeptide binding]; other site
391165002635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391165002636	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
391165002637	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
391165002638	putative molybdopterin cofactor binding site [chemical binding]; other site
391165002639	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
391165002640	putative molybdopterin cofactor binding site; other site
391165002641	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
391165002642	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391165002643	HIGH motif; other site
391165002644	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391165002645	active site
391165002646	KMSKS motif; other site
391165002647	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
391165002648	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
391165002649	Competence protein; Region: Competence; pfam03772
391165002650	LexA repressor; Validated; Region: PRK00215
391165002651	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
391165002652	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
391165002653	Catalytic site [active]
391165002654	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
391165002655	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
391165002656	dimer interface [polypeptide binding]; other site
391165002657	putative functional site; other site
391165002658	putative MPT binding site; other site
391165002659	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
391165002660	trimer interface [polypeptide binding]; other site
391165002661	dimer interface [polypeptide binding]; other site
391165002662	putative active site [active]
391165002663	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
391165002664	active site
391165002665	ribulose/triose binding site [chemical binding]; other site
391165002666	phosphate binding site [ion binding]; other site
391165002667	substrate (anthranilate) binding pocket [chemical binding]; other site
391165002668	product (indole) binding pocket [chemical binding]; other site
391165002669	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
391165002670	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
391165002671	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
391165002672	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
391165002673	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
391165002674	glutamine binding [chemical binding]; other site
391165002675	catalytic triad [active]
391165002676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165002677	binding surface
391165002678	TPR repeat; Region: TPR_11; pfam13414
391165002679	TPR motif; other site
391165002680	TPR repeat; Region: TPR_11; pfam13414
391165002681	Tetratricopeptide repeat; Region: TPR_16; pfam13432
391165002682	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165002683	TPR motif; other site
391165002684	binding surface
391165002685	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391165002686	Protein of unknown function, DUF488; Region: DUF488; pfam04343
391165002687	anthranilate synthase component I; Provisional; Region: PRK13573
391165002688	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
391165002689	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
391165002690	SurA N-terminal domain; Region: SurA_N_3; cl07813
391165002691	periplasmic folding chaperone; Provisional; Region: PRK10788
391165002692	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
391165002693	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
391165002694	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
391165002695	substrate binding site [chemical binding]; other site
391165002696	dimer interface [polypeptide binding]; other site
391165002697	catalytic triad [active]
391165002698	CTP synthetase; Validated; Region: pyrG; PRK05380
391165002699	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
391165002700	Catalytic site [active]
391165002701	active site
391165002702	UTP binding site [chemical binding]; other site
391165002703	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
391165002704	active site
391165002705	putative oxyanion hole; other site
391165002706	catalytic triad [active]
391165002707	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
391165002708	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
391165002709	Creatinine amidohydrolase; Region: Creatininase; pfam02633
391165002710	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
391165002711	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
391165002712	ligand binding site [chemical binding]; other site
391165002713	Low molecular weight phosphatase family; Region: LMWPc; cd00115
391165002714	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
391165002715	active site
391165002716	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
391165002717	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
391165002718	generic binding surface II; other site
391165002719	ssDNA binding site; other site
391165002720	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391165002721	ATP binding site [chemical binding]; other site
391165002722	putative Mg++ binding site [ion binding]; other site
391165002723	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165002724	nucleotide binding region [chemical binding]; other site
391165002725	ATP-binding site [chemical binding]; other site
391165002726	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
391165002727	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
391165002728	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
391165002729	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391165002730	ATP binding site [chemical binding]; other site
391165002731	putative Mg++ binding site [ion binding]; other site
391165002732	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165002733	nucleotide binding region [chemical binding]; other site
391165002734	ATP-binding site [chemical binding]; other site
391165002735	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
391165002736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
391165002737	MOSC domain; Region: MOSC; pfam03473
391165002738	3-alpha domain; Region: 3-alpha; pfam03475
391165002739	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
391165002740	putative cation:proton antiport protein; Provisional; Region: PRK10669
391165002741	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
391165002742	TrkA-N domain; Region: TrkA_N; pfam02254
391165002743	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
391165002744	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391165002745	catalytic residue [active]
391165002746	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
391165002747	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
391165002748	catalytic triad [active]
391165002749	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
391165002750	putative lipid kinase; Reviewed; Region: PRK13057
391165002751	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
391165002752	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
391165002753	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
391165002754	dimer interface [polypeptide binding]; other site
391165002755	motif 1; other site
391165002756	motif 2; other site
391165002757	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
391165002758	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
391165002759	GDP-binding site [chemical binding]; other site
391165002760	ACT binding site; other site
391165002761	IMP binding site; other site
391165002762	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
391165002763	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
391165002764	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391165002765	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391165002766	DNA binding residues [nucleotide binding]
391165002767	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
391165002768	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391165002769	RNA binding surface [nucleotide binding]; other site
391165002770	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
391165002771	active site
391165002772	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
391165002773	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
391165002774	putative active site [active]
391165002775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165002776	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
391165002777	active site
391165002778	motif I; other site
391165002779	motif II; other site
391165002780	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165002781	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
391165002782	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
391165002783	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
391165002784	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
391165002785	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
391165002786	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
391165002787	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
391165002788	putative active site [active]
391165002789	catalytic residue [active]
391165002790	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
391165002791	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
391165002792	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
391165002793	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
391165002794	TPP-binding site [chemical binding]; other site
391165002795	dimer interface [polypeptide binding]; other site
391165002796	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
391165002797	PYR/PP interface [polypeptide binding]; other site
391165002798	dimer interface [polypeptide binding]; other site
391165002799	TPP binding site [chemical binding]; other site
391165002800	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391165002801	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
391165002802	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391165002803	active site
391165002804	dimer interface [polypeptide binding]; other site
391165002805	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
391165002806	ATP-binding site [chemical binding]; other site
391165002807	Gluconate-6-phosphate binding site [chemical binding]; other site
391165002808	Shikimate kinase; Region: SKI; pfam01202
391165002809	Protein of unknown function (DUF461); Region: DUF461; pfam04314
391165002810	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
391165002811	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
391165002812	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
391165002813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
391165002814	SnoaL-like domain; Region: SnoaL_2; pfam12680
391165002815	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391165002816	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391165002817	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391165002818	dimerization interface [polypeptide binding]; other site
391165002819	putative DNA binding site [nucleotide binding]; other site
391165002820	putative Zn2+ binding site [ion binding]; other site
391165002821	peroxiredoxin; Provisional; Region: PRK13189
391165002822	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
391165002823	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
391165002824	Putative phosphatase (DUF442); Region: DUF442; cl17385
391165002825	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
391165002826	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
391165002827	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
391165002828	PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820
391165002829	active site
391165002830	catalytic triad [active]
391165002831	oxyanion hole [active]
391165002832	specificity pocket; other site
391165002833	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
391165002834	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
391165002835	Domain of unknown function (DUF336); Region: DUF336; pfam03928
391165002836	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
391165002837	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165002838	Walker A/P-loop; other site
391165002839	ATP binding site [chemical binding]; other site
391165002840	Q-loop/lid; other site
391165002841	ABC transporter signature motif; other site
391165002842	Walker B; other site
391165002843	D-loop; other site
391165002844	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391165002845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165002846	Walker A/P-loop; other site
391165002847	ATP binding site [chemical binding]; other site
391165002848	Q-loop/lid; other site
391165002849	ABC transporter signature motif; other site
391165002850	Walker B; other site
391165002851	D-loop; other site
391165002852	H-loop/switch region; other site
391165002853	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391165002854	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165002855	Walker A/P-loop; other site
391165002856	ATP binding site [chemical binding]; other site
391165002857	Q-loop/lid; other site
391165002858	ABC transporter signature motif; other site
391165002859	Walker B; other site
391165002860	D-loop; other site
391165002861	H-loop/switch region; other site
391165002862	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391165002863	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391165002864	substrate binding pocket [chemical binding]; other site
391165002865	membrane-bound complex binding site; other site
391165002866	hinge residues; other site
391165002867	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
391165002868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165002869	dimer interface [polypeptide binding]; other site
391165002870	conserved gate region; other site
391165002871	putative PBP binding loops; other site
391165002872	ABC-ATPase subunit interface; other site
391165002873	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
391165002874	ligand binding site [chemical binding]; other site
391165002875	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
391165002876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391165002877	ATP binding site [chemical binding]; other site
391165002878	putative Mg++ binding site [ion binding]; other site
391165002879	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165002880	nucleotide binding region [chemical binding]; other site
391165002881	ATP-binding site [chemical binding]; other site
391165002882	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
391165002883	HRDC domain; Region: HRDC; pfam00570
391165002884	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
391165002885	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
391165002886	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
391165002887	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
391165002888	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
391165002889	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
391165002890	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
391165002891	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
391165002892	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
391165002893	Cysteine-rich domain; Region: CCG; pfam02754
391165002894	Cysteine-rich domain; Region: CCG; pfam02754
391165002895	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
391165002896	Class I ribonucleotide reductase; Region: RNR_I; cd01679
391165002897	active site
391165002898	dimer interface [polypeptide binding]; other site
391165002899	catalytic residues [active]
391165002900	effector binding site; other site
391165002901	R2 peptide binding site; other site
391165002902	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
391165002903	dimer interface [polypeptide binding]; other site
391165002904	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
391165002905	putative radical transfer pathway; other site
391165002906	diiron center [ion binding]; other site
391165002907	tyrosyl radical; other site
391165002908	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
391165002909	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
391165002910	Cu(I) binding site [ion binding]; other site
391165002911	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
391165002912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165002913	S-adenosylmethionine binding site [chemical binding]; other site
391165002914	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
391165002915	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
391165002916	substrate binding pocket [chemical binding]; other site
391165002917	chain length determination region; other site
391165002918	substrate-Mg2+ binding site; other site
391165002919	catalytic residues [active]
391165002920	aspartate-rich region 1; other site
391165002921	active site lid residues [active]
391165002922	aspartate-rich region 2; other site
391165002923	Predicted metalloprotease [General function prediction only]; Region: COG2321
391165002924	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
391165002925	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391165002926	active site
391165002927	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
391165002928	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
391165002929	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
391165002930	dimer interface [polypeptide binding]; other site
391165002931	active site
391165002932	citrylCoA binding site [chemical binding]; other site
391165002933	NADH binding [chemical binding]; other site
391165002934	cationic pore residues; other site
391165002935	oxalacetate/citrate binding site [chemical binding]; other site
391165002936	coenzyme A binding site [chemical binding]; other site
391165002937	catalytic triad [active]
391165002938	Staphylococcal nuclease homologues; Region: SNc; smart00318
391165002939	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
391165002940	Catalytic site; other site
391165002941	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
391165002942	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391165002943	catalytic core [active]
391165002944	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391165002945	active site
391165002946	metal binding site [ion binding]; metal-binding site
391165002947	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
391165002948	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
391165002949	putative active site [active]
391165002950	putative metal binding site [ion binding]; other site
391165002951	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
391165002952	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391165002953	ATP binding site [chemical binding]; other site
391165002954	putative Mg++ binding site [ion binding]; other site
391165002955	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165002956	nucleotide binding region [chemical binding]; other site
391165002957	ATP-binding site [chemical binding]; other site
391165002958	DEAD/H associated; Region: DEAD_assoc; pfam08494
391165002959	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
391165002960	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
391165002961	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
391165002962	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
391165002963	active site
391165002964	DNA binding site [nucleotide binding]
391165002965	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
391165002966	DNA binding site [nucleotide binding]
391165002967	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
391165002968	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
391165002969	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
391165002970	dimer interface [polypeptide binding]; other site
391165002971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165002972	catalytic residue [active]
391165002973	Rrf2 family protein; Region: rrf2_super; TIGR00738
391165002974	Transcriptional regulator; Region: Rrf2; cl17282
391165002975	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
391165002976	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
391165002977	dimer interface [polypeptide binding]; other site
391165002978	decamer (pentamer of dimers) interface [polypeptide binding]; other site
391165002979	catalytic triad [active]
391165002980	sulfite reductase subunit beta; Provisional; Region: PRK13504
391165002981	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
391165002982	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
391165002983	PBP superfamily domain; Region: PBP_like_2; cl17296
391165002984	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
391165002985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165002986	dimer interface [polypeptide binding]; other site
391165002987	conserved gate region; other site
391165002988	putative PBP binding loops; other site
391165002989	ABC-ATPase subunit interface; other site
391165002990	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
391165002991	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165002992	dimer interface [polypeptide binding]; other site
391165002993	conserved gate region; other site
391165002994	putative PBP binding loops; other site
391165002995	ABC-ATPase subunit interface; other site
391165002996	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
391165002997	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
391165002998	Walker A/P-loop; other site
391165002999	ATP binding site [chemical binding]; other site
391165003000	Q-loop/lid; other site
391165003001	ABC transporter signature motif; other site
391165003002	Walker B; other site
391165003003	D-loop; other site
391165003004	H-loop/switch region; other site
391165003005	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
391165003006	PhoU domain; Region: PhoU; pfam01895
391165003007	PhoU domain; Region: PhoU; pfam01895
391165003008	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
391165003009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165003010	active site
391165003011	phosphorylation site [posttranslational modification]
391165003012	intermolecular recognition site; other site
391165003013	dimerization interface [polypeptide binding]; other site
391165003014	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165003015	DNA binding site [nucleotide binding]
391165003016	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.   The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153
391165003017	homotrimer interaction site [polypeptide binding]; other site
391165003018	putative active site [active]
391165003019	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
391165003020	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
391165003021	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
391165003022	active site
391165003023	catalytic site [active]
391165003024	CHAP domain; Region: CHAP; cl17642
391165003025	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
391165003026	homotrimer interaction site [polypeptide binding]; other site
391165003027	putative active site [active]
391165003028	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
391165003029	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
391165003030	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
391165003031	XdhC Rossmann domain; Region: XdhC_C; pfam13478
391165003032	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
391165003033	putative MPT binding site; other site
391165003034	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
391165003035	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
391165003036	Ligand binding site; other site
391165003037	metal-binding site
391165003038	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
391165003039	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165003040	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165003041	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
391165003042	putative effector binding pocket; other site
391165003043	putative dimerization interface [polypeptide binding]; other site
391165003044	short chain dehydrogenase; Provisional; Region: PRK12744
391165003045	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165003046	NAD(P) binding site [chemical binding]; other site
391165003047	active site
391165003048	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
391165003049	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
391165003050	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
391165003051	protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944
391165003052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165003053	S-adenosylmethionine binding site [chemical binding]; other site
391165003054	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
391165003055	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
391165003056	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391165003057	active site
391165003058	HIGH motif; other site
391165003059	nucleotide binding site [chemical binding]; other site
391165003060	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
391165003061	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
391165003062	active site
391165003063	KMSKS motif; other site
391165003064	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
391165003065	tRNA binding surface [nucleotide binding]; other site
391165003066	anticodon binding site; other site
391165003067	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
391165003068	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
391165003069	putative nucleotide binding site [chemical binding]; other site
391165003070	uridine monophosphate binding site [chemical binding]; other site
391165003071	homohexameric interface [polypeptide binding]; other site
391165003072	ribosome recycling factor; Reviewed; Region: frr; PRK00083
391165003073	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
391165003074	hinge region; other site
391165003075	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
391165003076	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
391165003077	catalytic residue [active]
391165003078	putative FPP diphosphate  binding site; other site
391165003079	putative FPP binding hydrophobic cleft; other site
391165003080	dimer interface [polypeptide binding]; other site
391165003081	putative IPP diphosphate binding site; other site
391165003082	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
391165003083	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
391165003084	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
391165003085	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
391165003086	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
391165003087	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
391165003088	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
391165003089	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
391165003090	active site
391165003091	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
391165003092	protein binding site [polypeptide binding]; other site
391165003093	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
391165003094	putative substrate binding region [chemical binding]; other site
391165003095	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
391165003096	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391165003097	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391165003098	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391165003099	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391165003100	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
391165003101	Surface antigen; Region: Bac_surface_Ag; pfam01103
391165003102	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
391165003103	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
391165003104	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
391165003105	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
391165003106	trimer interface [polypeptide binding]; other site
391165003107	active site
391165003108	UDP-GlcNAc binding site [chemical binding]; other site
391165003109	lipid binding site [chemical binding]; lipid-binding site
391165003110	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
391165003111	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
391165003112	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
391165003113	active site
391165003114	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
391165003115	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
391165003116	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
391165003117	dimer interface [polypeptide binding]; other site
391165003118	active site
391165003119	metal binding site [ion binding]; metal-binding site
391165003120	glutathione binding site [chemical binding]; other site
391165003121	YcjX-like family, DUF463; Region: DUF463; pfam04317
391165003122	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
391165003123	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
391165003124	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
391165003125	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
391165003126	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
391165003127	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
391165003128	GatB domain; Region: GatB_Yqey; smart00845
391165003129	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
391165003130	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
391165003131	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
391165003132	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
391165003133	substrate binding pocket [chemical binding]; other site
391165003134	substrate-Mg2+ binding site; other site
391165003135	aspartate-rich region 2; other site
391165003136	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
391165003137	glutamine synthetase; Provisional; Region: glnA; PRK09469
391165003138	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
391165003139	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
391165003140	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
391165003141	Nitrogen regulatory protein P-II; Region: P-II; smart00938
391165003142	hypothetical protein; Provisional; Region: PRK08912
391165003143	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391165003144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165003145	homodimer interface [polypeptide binding]; other site
391165003146	catalytic residue [active]
391165003147	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
391165003148	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
391165003149	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
391165003150	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
391165003151	metal binding site [ion binding]; metal-binding site
391165003152	putative dimer interface [polypeptide binding]; other site
391165003153	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
391165003154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165003155	NAD(P) binding site [chemical binding]; other site
391165003156	active site
391165003157	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
391165003158	23S rRNA interface [nucleotide binding]; other site
391165003159	L3 interface [polypeptide binding]; other site
391165003160	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
391165003161	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
391165003162	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
391165003163	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
391165003164	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
391165003165	trimer interface [polypeptide binding]; other site
391165003166	putative metal binding site [ion binding]; other site
391165003167	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
391165003168	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
391165003169	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
391165003170	homodimer interface [polypeptide binding]; other site
391165003171	substrate-cofactor binding pocket; other site
391165003172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165003173	catalytic residue [active]
391165003174	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
391165003175	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
391165003176	active site residue [active]
391165003177	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
391165003178	active site residue [active]
391165003179	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391165003180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165003181	non-specific DNA binding site [nucleotide binding]; other site
391165003182	salt bridge; other site
391165003183	sequence-specific DNA binding site [nucleotide binding]; other site
391165003184	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
391165003185	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
391165003186	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
391165003187	hypothetical protein; Reviewed; Region: PRK12497
391165003188	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
391165003189	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391165003190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165003191	Walker A motif; other site
391165003192	ATP binding site [chemical binding]; other site
391165003193	Walker B motif; other site
391165003194	arginine finger; other site
391165003195	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
391165003196	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
391165003197	Domain of unknown function DUF21; Region: DUF21; pfam01595
391165003198	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
391165003199	Transporter associated domain; Region: CorC_HlyC; smart01091
391165003200	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
391165003201	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
391165003202	catalytic residues [active]
391165003203	glucokinase, proteobacterial type; Region: glk; TIGR00749
391165003204	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391165003205	nucleotide binding site [chemical binding]; other site
391165003206	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
391165003207	alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686
391165003208	PhnA protein; Region: PhnA; pfam03831
391165003209	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391165003210	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
391165003211	Ligand binding site; other site
391165003212	DXD motif; other site
391165003213	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
391165003214	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
391165003215	Uncharacterized conserved protein [Function unknown]; Region: COG1432
391165003216	LabA_like proteins; Region: LabA; cd10911
391165003217	putative metal binding site [ion binding]; other site
391165003218	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
391165003219	catalytic center binding site [active]
391165003220	ATP binding site [chemical binding]; other site
391165003221	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
391165003222	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391165003223	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391165003224	Zn2+ binding site [ion binding]; other site
391165003225	Mg2+ binding site [ion binding]; other site
391165003226	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
391165003227	synthetase active site [active]
391165003228	NTP binding site [chemical binding]; other site
391165003229	metal binding site [ion binding]; metal-binding site
391165003230	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
391165003231	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
391165003232	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
391165003233	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
391165003234	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
391165003235	Catalytic site [active]
391165003236	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
391165003237	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
391165003238	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
391165003239	dimerization interface [polypeptide binding]; other site
391165003240	active site
391165003241	metal binding site [ion binding]; metal-binding site
391165003242	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
391165003243	dsRNA binding site [nucleotide binding]; other site
391165003244	GTPase Era; Reviewed; Region: era; PRK00089
391165003245	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
391165003246	G1 box; other site
391165003247	GTP/Mg2+ binding site [chemical binding]; other site
391165003248	Switch I region; other site
391165003249	G2 box; other site
391165003250	Switch II region; other site
391165003251	G3 box; other site
391165003252	G4 box; other site
391165003253	G5 box; other site
391165003254	KH domain; Region: KH_2; pfam07650
391165003255	G-X-X-G motif; other site
391165003256	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
391165003257	Recombination protein O N terminal; Region: RecO_N; pfam11967
391165003258	Recombination protein O C terminal; Region: RecO_C; pfam02565
391165003259	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
391165003260	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
391165003261	CAP-like domain; other site
391165003262	active site
391165003263	primary dimer interface [polypeptide binding]; other site
391165003264	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
391165003265	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
391165003266	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
391165003267	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
391165003268	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
391165003269	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
391165003270	active site
391165003271	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391165003272	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
391165003273	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391165003274	catalytic loop [active]
391165003275	iron binding site [ion binding]; other site
391165003276	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
391165003277	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
391165003278	dimer interface [polypeptide binding]; other site
391165003279	allosteric magnesium binding site [ion binding]; other site
391165003280	active site
391165003281	aspartate-rich active site metal binding site; other site
391165003282	Schiff base residues; other site
391165003283	thiamine monophosphate kinase; Provisional; Region: PRK05731
391165003284	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
391165003285	ATP binding site [chemical binding]; other site
391165003286	dimerization interface [polypeptide binding]; other site
391165003287	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
391165003288	putative RNA binding site [nucleotide binding]; other site
391165003289	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
391165003290	homopentamer interface [polypeptide binding]; other site
391165003291	active site
391165003292	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
391165003293	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
391165003294	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
391165003295	dimerization interface [polypeptide binding]; other site
391165003296	active site
391165003297	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
391165003298	Lumazine binding domain; Region: Lum_binding; pfam00677
391165003299	Lumazine binding domain; Region: Lum_binding; pfam00677
391165003300	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
391165003301	ATP cone domain; Region: ATP-cone; pfam03477
391165003302	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
391165003303	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
391165003304	dimer interface [polypeptide binding]; other site
391165003305	active site
391165003306	glycine-pyridoxal phosphate binding site [chemical binding]; other site
391165003307	folate binding site [chemical binding]; other site
391165003308	amino acid transporter; Region: 2A0306; TIGR00909
391165003309	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
391165003310	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
391165003311	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
391165003312	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
391165003313	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
391165003314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391165003315	putative phosphate acyltransferase; Provisional; Region: PRK05331
391165003316	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
391165003317	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
391165003318	dimer interface [polypeptide binding]; other site
391165003319	active site
391165003320	CoA binding pocket [chemical binding]; other site
391165003321	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
391165003322	IHF dimer interface [polypeptide binding]; other site
391165003323	IHF - DNA interface [nucleotide binding]; other site
391165003324	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
391165003325	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
391165003326	DNA binding residues [nucleotide binding]
391165003327	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
391165003328	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
391165003329	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
391165003330	substrate binding site; other site
391165003331	dimer interface; other site
391165003332	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
391165003333	homotrimer interaction site [polypeptide binding]; other site
391165003334	zinc binding site [ion binding]; other site
391165003335	CDP-binding sites; other site
391165003336	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
391165003337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165003338	active site
391165003339	phosphorylation site [posttranslational modification]
391165003340	intermolecular recognition site; other site
391165003341	dimerization interface [polypeptide binding]; other site
391165003342	CsbD-like; Region: CsbD; pfam05532
391165003343	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
391165003344	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
391165003345	NAD(P) binding site [chemical binding]; other site
391165003346	catalytic residues [active]
391165003347	Protein of unknown function (DUF779); Region: DUF779; pfam05610
391165003348	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
391165003349	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
391165003350	FAD binding pocket [chemical binding]; other site
391165003351	FAD binding motif [chemical binding]; other site
391165003352	phosphate binding motif [ion binding]; other site
391165003353	beta-alpha-beta structure motif; other site
391165003354	NAD binding pocket [chemical binding]; other site
391165003355	Domain of unknown function (DUF329); Region: DUF329; pfam03884
391165003356	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
391165003357	homodimer interface [polypeptide binding]; other site
391165003358	oligonucleotide binding site [chemical binding]; other site
391165003359	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
391165003360	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
391165003361	active site
391165003362	dimer interface [polypeptide binding]; other site
391165003363	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
391165003364	rRNA binding site [nucleotide binding]; other site
391165003365	predicted 30S ribosome binding site; other site
391165003366	histidinol dehydrogenase; Region: hisD; TIGR00069
391165003367	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
391165003368	NAD binding site [chemical binding]; other site
391165003369	dimerization interface [polypeptide binding]; other site
391165003370	product binding site; other site
391165003371	substrate binding site [chemical binding]; other site
391165003372	zinc binding site [ion binding]; other site
391165003373	catalytic residues [active]
391165003374	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
391165003375	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
391165003376	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
391165003377	catalytic residues [active]
391165003378	dimer interface [polypeptide binding]; other site
391165003379	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
391165003380	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
391165003381	N-terminal plug; other site
391165003382	ligand-binding site [chemical binding]; other site
391165003383	Methyltransferase domain; Region: Methyltransf_23; pfam13489
391165003384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165003385	S-adenosylmethionine binding site [chemical binding]; other site
391165003386	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
391165003387	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
391165003388	hinge; other site
391165003389	active site
391165003390	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
391165003391	trimer interface [polypeptide binding]; other site
391165003392	active site
391165003393	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
391165003394	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
391165003395	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
391165003396	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
391165003397	active site
391165003398	fumarate hydratase; Reviewed; Region: fumC; PRK00485
391165003399	Class II fumarases; Region: Fumarase_classII; cd01362
391165003400	active site
391165003401	tetramer interface [polypeptide binding]; other site
391165003402	Uncharacterized conserved protein [Function unknown]; Region: COG2966
391165003403	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
391165003404	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
391165003405	Cupin domain; Region: Cupin_2; cl17218
391165003406	malate:quinone oxidoreductase; Validated; Region: PRK05257
391165003407	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
391165003408	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
391165003409	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391165003410	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391165003411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391165003412	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391165003413	enoyl_reductase_like; Region: enoyl_reductase_like; cd08249
391165003414	L-threonine 3-dehydrogenase; Region: tdh; TIGR00692
391165003415	NAD(P) binding site [chemical binding]; other site
391165003416	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165003417	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
391165003418	putative effector binding pocket; other site
391165003419	putative dimerization interface [polypeptide binding]; other site
391165003420	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
391165003421	classical (c) SDRs; Region: SDR_c; cd05233
391165003422	NAD(P) binding site [chemical binding]; other site
391165003423	active site
391165003424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165003425	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391165003426	putative substrate translocation pore; other site
391165003427	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391165003428	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
391165003429	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
391165003430	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
391165003431	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
391165003432	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
391165003433	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
391165003434	putative active site [active]
391165003435	metal binding site [ion binding]; metal-binding site
391165003436	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
391165003437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165003438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165003439	LysR substrate binding domain; Region: LysR_substrate; pfam03466
391165003440	dimerization interface [polypeptide binding]; other site
391165003441	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
391165003442	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
391165003443	putative NAD(P) binding site [chemical binding]; other site
391165003444	Protein of unknown function (DUF2699); Region: DUF2699; pfam10919
391165003445	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
391165003446	conjugal transfer protein TrbL; Provisional; Region: PRK13875
391165003447	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
391165003448	conjugal transfer protein TrbF; Provisional; Region: PRK13872
391165003449	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
391165003450	VirB7 interaction site; other site
391165003451	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
391165003452	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
391165003453	Predicted transcriptional regulator [Transcription]; Region: COG4190
391165003454	Helix-turn-helix domain; Region: HTH_20; pfam12840
391165003455	putative DNA binding site [nucleotide binding]; other site
391165003456	putative Zn2+ binding site [ion binding]; other site
391165003457	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
391165003458	Transglycosylase SLT domain; Region: SLT_2; pfam13406
391165003459	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391165003460	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391165003461	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
391165003462	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
391165003463	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
391165003464	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
391165003465	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
391165003466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391165003467	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391165003468	WHG domain; Region: WHG; pfam13305
391165003469	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
391165003470	thymidylate kinase; Validated; Region: tmk; PRK00698
391165003471	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
391165003472	TMP-binding site; other site
391165003473	ATP-binding site [chemical binding]; other site
391165003474	DNA polymerase III subunit delta'; Validated; Region: PRK07471
391165003475	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165003476	Walker A motif; other site
391165003477	ATP binding site [chemical binding]; other site
391165003478	Walker B motif; other site
391165003479	arginine finger; other site
391165003480	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
391165003481	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
391165003482	active site
391165003483	HIGH motif; other site
391165003484	KMSKS motif; other site
391165003485	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
391165003486	tRNA binding surface [nucleotide binding]; other site
391165003487	anticodon binding site; other site
391165003488	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
391165003489	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
391165003490	active site
391165003491	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
391165003492	putative hydrolase; Provisional; Region: PRK02113
391165003493	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
391165003494	hypothetical protein; Validated; Region: PRK09039
391165003495	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
391165003496	ligand binding site [chemical binding]; other site
391165003497	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
391165003498	ligand binding site [chemical binding]; other site
391165003499	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
391165003500	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
391165003501	active site
391165003502	dimerization interface [polypeptide binding]; other site
391165003503	elongation factor P; Validated; Region: PRK00529
391165003504	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
391165003505	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
391165003506	RNA binding site [nucleotide binding]; other site
391165003507	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
391165003508	RNA binding site [nucleotide binding]; other site
391165003509	Radical SAM superfamily; Region: Radical_SAM; pfam04055
391165003510	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165003511	FeS/SAM binding site; other site
391165003512	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
391165003513	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
391165003514	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391165003515	motif 1; other site
391165003516	dimer interface [polypeptide binding]; other site
391165003517	active site
391165003518	motif 2; other site
391165003519	motif 3; other site
391165003520	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
391165003521	thiamine phosphate binding site [chemical binding]; other site
391165003522	active site
391165003523	pyrophosphate binding site [ion binding]; other site
391165003524	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
391165003525	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
391165003526	putative active site; other site
391165003527	catalytic residue [active]
391165003528	Cell division protein ZapA; Region: ZapA; pfam05164
391165003529	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
391165003530	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
391165003531	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
391165003532	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
391165003533	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
391165003534	putative active site [active]
391165003535	metal binding site [ion binding]; metal-binding site
391165003536	homodimer binding site [polypeptide binding]; other site
391165003537	hypothetical protein; Validated; Region: PRK00110
391165003538	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
391165003539	active site
391165003540	putative DNA-binding cleft [nucleotide binding]; other site
391165003541	dimer interface [polypeptide binding]; other site
391165003542	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
391165003543	RuvA N terminal domain; Region: RuvA_N; pfam01330
391165003544	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
391165003545	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
391165003546	putative FMN binding site [chemical binding]; other site
391165003547	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
391165003548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165003549	Walker A motif; other site
391165003550	ATP binding site [chemical binding]; other site
391165003551	Walker B motif; other site
391165003552	arginine finger; other site
391165003553	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
391165003554	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
391165003555	active site
391165003556	TolQ protein; Region: tolQ; TIGR02796
391165003557	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
391165003558	TolR protein; Region: tolR; TIGR02801
391165003559	TolB amino-terminal domain; Region: TolB_N; pfam04052
391165003560	translocation protein TolB; Provisional; Region: tolB; PRK05137
391165003561	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
391165003562	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
391165003563	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
391165003564	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
391165003565	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
391165003566	ligand binding site [chemical binding]; other site
391165003567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
391165003568	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
391165003569	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
391165003570	Ligand Binding Site [chemical binding]; other site
391165003571	FtsH Extracellular; Region: FtsH_ext; pfam06480
391165003572	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
391165003573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165003574	Walker A motif; other site
391165003575	ATP binding site [chemical binding]; other site
391165003576	Walker B motif; other site
391165003577	arginine finger; other site
391165003578	Peptidase family M41; Region: Peptidase_M41; pfam01434
391165003579	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
391165003580	dihydropteroate synthase; Region: DHPS; TIGR01496
391165003581	substrate binding pocket [chemical binding]; other site
391165003582	dimer interface [polypeptide binding]; other site
391165003583	inhibitor binding site; inhibition site
391165003584	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
391165003585	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
391165003586	active site
391165003587	substrate binding site [chemical binding]; other site
391165003588	metal binding site [ion binding]; metal-binding site
391165003589	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
391165003590	dimer interface [polypeptide binding]; other site
391165003591	substrate binding site [chemical binding]; other site
391165003592	ATP binding site [chemical binding]; other site
391165003593	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
391165003594	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391165003595	active site
391165003596	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
391165003597	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
391165003598	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
391165003599	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
391165003600	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
391165003601	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
391165003602	active site
391165003603	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
391165003604	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
391165003605	homodimer interface [polypeptide binding]; other site
391165003606	substrate-cofactor binding pocket; other site
391165003607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165003608	catalytic residue [active]
391165003609	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
391165003610	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165003611	motif II; other site
391165003612	bacterial Hfq-like; Region: Hfq; cd01716
391165003613	hexamer interface [polypeptide binding]; other site
391165003614	Sm1 motif; other site
391165003615	RNA binding site [nucleotide binding]; other site
391165003616	Sm2 motif; other site
391165003617	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
391165003618	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
391165003619	HflX GTPase family; Region: HflX; cd01878
391165003620	G1 box; other site
391165003621	GTP/Mg2+ binding site [chemical binding]; other site
391165003622	Switch I region; other site
391165003623	G2 box; other site
391165003624	G3 box; other site
391165003625	Switch II region; other site
391165003626	G4 box; other site
391165003627	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
391165003628	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
391165003629	active site
391165003630	putative lithium-binding site [ion binding]; other site
391165003631	substrate binding site [chemical binding]; other site
391165003632	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
391165003633	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
391165003634	homodimer interface [polypeptide binding]; other site
391165003635	metal binding site [ion binding]; metal-binding site
391165003636	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
391165003637	homodimer interface [polypeptide binding]; other site
391165003638	active site
391165003639	putative chemical substrate binding site [chemical binding]; other site
391165003640	metal binding site [ion binding]; metal-binding site
391165003641	HPP family; Region: HPP; pfam04982
391165003642	PAS domain; Region: PAS_9; pfam13426
391165003643	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
391165003644	putative active site [active]
391165003645	heme pocket [chemical binding]; other site
391165003646	CheB methylesterase; Region: CheB_methylest; pfam01339
391165003647	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
391165003648	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
391165003649	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
391165003650	PAS domain; Region: PAS_10; pfam13596
391165003651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
391165003652	heme pocket [chemical binding]; other site
391165003653	putative active site [active]
391165003654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
391165003655	HWE histidine kinase; Region: HWE_HK; smart00911
391165003656	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
391165003657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165003658	active site
391165003659	phosphorylation site [posttranslational modification]
391165003660	intermolecular recognition site; other site
391165003661	dimerization interface [polypeptide binding]; other site
391165003662	Hint domain; Region: Hint_2; pfam13403
391165003663	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
391165003664	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
391165003665	active site
391165003666	HIGH motif; other site
391165003667	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
391165003668	KMSKS motif; other site
391165003669	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
391165003670	tRNA binding surface [nucleotide binding]; other site
391165003671	anticodon binding site; other site
391165003672	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
391165003673	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
391165003674	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
391165003675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165003676	NAD(P) binding site [chemical binding]; other site
391165003677	active site
391165003678	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
391165003679	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
391165003680	inhibitor-cofactor binding pocket; inhibition site
391165003681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165003682	catalytic residue [active]
391165003683	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
391165003684	putative trimer interface [polypeptide binding]; other site
391165003685	putative CoA binding site [chemical binding]; other site
391165003686	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
391165003687	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391165003688	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391165003689	active site
391165003690	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
391165003691	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
391165003692	putative [4Fe-4S] binding site [ion binding]; other site
391165003693	putative molybdopterin cofactor binding site [chemical binding]; other site
391165003694	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
391165003695	putative molybdopterin cofactor binding site; other site
391165003696	exopolyphosphatase; Region: exo_poly_only; TIGR03706
391165003697	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
391165003698	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
391165003699	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
391165003700	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
391165003701	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
391165003702	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
391165003703	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
391165003704	active site
391165003705	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
391165003706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165003707	S-adenosylmethionine binding site [chemical binding]; other site
391165003708	GMP synthase; Reviewed; Region: guaA; PRK00074
391165003709	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
391165003710	AMP/PPi binding site [chemical binding]; other site
391165003711	candidate oxyanion hole; other site
391165003712	catalytic triad [active]
391165003713	potential glutamine specificity residues [chemical binding]; other site
391165003714	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
391165003715	ATP Binding subdomain [chemical binding]; other site
391165003716	Ligand Binding sites [chemical binding]; other site
391165003717	Dimerization subdomain; other site
391165003718	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
391165003719	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
391165003720	active site
391165003721	Int/Topo IB signature motif; other site
391165003722	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
391165003723	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
391165003724	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
391165003725	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
391165003726	Cupin domain; Region: Cupin_2; cl17218
391165003727	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165003728	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165003729	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
391165003730	dimerization interface [polypeptide binding]; other site
391165003731	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
391165003732	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
391165003733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165003734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165003735	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
391165003736	putative effector binding pocket; other site
391165003737	dimerization interface [polypeptide binding]; other site
391165003738	Predicted transcriptional regulators [Transcription]; Region: COG1733
391165003739	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391165003740	putative DNA binding site [nucleotide binding]; other site
391165003741	putative Zn2+ binding site [ion binding]; other site
391165003742	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
391165003743	classical (c) SDRs; Region: SDR_c; cd05233
391165003744	NAD(P) binding site [chemical binding]; other site
391165003745	active site
391165003746	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
391165003747	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391165003748	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
391165003749	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
391165003750	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
391165003751	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165003752	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
391165003753	dimerization interface [polypeptide binding]; other site
391165003754	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
391165003755	homodimer interaction site [polypeptide binding]; other site
391165003756	cofactor binding site; other site
391165003757	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
391165003758	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
391165003759	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391165003760	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
391165003761	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
391165003762	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
391165003763	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391165003764	Coenzyme A binding pocket [chemical binding]; other site
391165003765	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
391165003766	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
391165003767	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
391165003768	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165003769	Walker A/P-loop; other site
391165003770	ATP binding site [chemical binding]; other site
391165003771	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
391165003772	putative active site [active]
391165003773	putative metal-binding site [ion binding]; other site
391165003774	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
391165003775	Part of AAA domain; Region: AAA_19; pfam13245
391165003776	enolase; Provisional; Region: eno; PRK00077
391165003777	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
391165003778	dimer interface [polypeptide binding]; other site
391165003779	metal binding site [ion binding]; metal-binding site
391165003780	substrate binding pocket [chemical binding]; other site
391165003781	Septum formation initiator; Region: DivIC; cl17659
391165003782	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
391165003783	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
391165003784	tetramer interface [polypeptide binding]; other site
391165003785	TPP-binding site [chemical binding]; other site
391165003786	heterodimer interface [polypeptide binding]; other site
391165003787	phosphorylation loop region [posttranslational modification]
391165003788	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
391165003789	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
391165003790	E3 interaction surface; other site
391165003791	lipoyl attachment site [posttranslational modification]; other site
391165003792	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
391165003793	alpha subunit interface [polypeptide binding]; other site
391165003794	TPP binding site [chemical binding]; other site
391165003795	heterodimer interface [polypeptide binding]; other site
391165003796	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391165003797	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
391165003798	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
391165003799	E3 interaction surface; other site
391165003800	lipoyl attachment site [posttranslational modification]; other site
391165003801	e3 binding domain; Region: E3_binding; pfam02817
391165003802	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
391165003803	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
391165003804	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391165003805	Coenzyme A binding pocket [chemical binding]; other site
391165003806	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
391165003807	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165003808	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391165003809	lipoyl synthase; Provisional; Region: PRK05481
391165003810	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165003811	FeS/SAM binding site; other site
391165003812	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
391165003813	putative coenzyme Q binding site [chemical binding]; other site
391165003814	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
391165003815	Amidinotransferase; Region: Amidinotransf; cl12043
391165003816	Competence-damaged protein; Region: CinA; pfam02464
391165003817	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
391165003818	tetramer interfaces [polypeptide binding]; other site
391165003819	binuclear metal-binding site [ion binding]; other site
391165003820	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
391165003821	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391165003822	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391165003823	catalytic residue [active]
391165003824	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
391165003825	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
391165003826	dimer interface [polypeptide binding]; other site
391165003827	active site
391165003828	catalytic residue [active]
391165003829	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
391165003830	SmpB-tmRNA interface; other site
391165003831	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
391165003832	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
391165003833	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
391165003834	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
391165003835	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
391165003836	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391165003837	Walker A/P-loop; other site
391165003838	ATP binding site [chemical binding]; other site
391165003839	Q-loop/lid; other site
391165003840	ABC transporter signature motif; other site
391165003841	Walker B; other site
391165003842	D-loop; other site
391165003843	H-loop/switch region; other site
391165003844	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
391165003845	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
391165003846	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
391165003847	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
391165003848	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
391165003849	nudix motif; other site
391165003850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165003851	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391165003852	putative substrate translocation pore; other site
391165003853	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
391165003854	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
391165003855	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
391165003856	metal binding site [ion binding]; metal-binding site
391165003857	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
391165003858	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
391165003859	dimer interface [polypeptide binding]; other site
391165003860	putative PBP binding regions; other site
391165003861	ABC-ATPase subunit  interface; other site
391165003862	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
391165003863	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
391165003864	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391165003865	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
391165003866	metal binding site 2 [ion binding]; metal-binding site
391165003867	putative DNA binding helix; other site
391165003868	metal binding site 1 [ion binding]; metal-binding site
391165003869	dimer interface [polypeptide binding]; other site
391165003870	structural Zn2+ binding site [ion binding]; other site
391165003871	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
391165003872	HerA helicase [Replication, recombination, and repair]; Region: COG0433
391165003873	TMAO/DMSO reductase; Reviewed; Region: PRK05363
391165003874	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
391165003875	Moco binding site; other site
391165003876	metal coordination site [ion binding]; other site
391165003877	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
391165003878	active site
391165003879	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
391165003880	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
391165003881	active site
391165003882	(T/H)XGH motif; other site
391165003883	DNA gyrase, A subunit; Region: gyrA; TIGR01063
391165003884	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
391165003885	CAP-like domain; other site
391165003886	active site
391165003887	primary dimer interface [polypeptide binding]; other site
391165003888	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391165003889	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391165003890	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391165003891	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391165003892	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391165003893	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391165003894	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391165003895	dimer interface [polypeptide binding]; other site
391165003896	ssDNA binding site [nucleotide binding]; other site
391165003897	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391165003898	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
391165003899	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391165003900	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391165003901	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
391165003902	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
391165003903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165003904	active site
391165003905	phosphorylation site [posttranslational modification]
391165003906	intermolecular recognition site; other site
391165003907	dimerization interface [polypeptide binding]; other site
391165003908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165003909	Walker A motif; other site
391165003910	ATP binding site [chemical binding]; other site
391165003911	Walker B motif; other site
391165003912	arginine finger; other site
391165003913	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
391165003914	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
391165003915	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391165003916	dimerization interface [polypeptide binding]; other site
391165003917	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165003918	dimer interface [polypeptide binding]; other site
391165003919	phosphorylation site [posttranslational modification]
391165003920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165003921	ATP binding site [chemical binding]; other site
391165003922	Mg2+ binding site [ion binding]; other site
391165003923	G-X-G motif; other site
391165003924	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
391165003925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165003926	active site
391165003927	phosphorylation site [posttranslational modification]
391165003928	intermolecular recognition site; other site
391165003929	dimerization interface [polypeptide binding]; other site
391165003930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165003931	Walker A motif; other site
391165003932	ATP binding site [chemical binding]; other site
391165003933	Walker B motif; other site
391165003934	arginine finger; other site
391165003935	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
391165003936	PAS domain; Region: PAS; smart00091
391165003937	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
391165003938	putative active site [active]
391165003939	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165003940	dimer interface [polypeptide binding]; other site
391165003941	phosphorylation site [posttranslational modification]
391165003942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165003943	ATP binding site [chemical binding]; other site
391165003944	Mg2+ binding site [ion binding]; other site
391165003945	G-X-G motif; other site
391165003946	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
391165003947	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
391165003948	FMN binding site [chemical binding]; other site
391165003949	active site
391165003950	catalytic residues [active]
391165003951	substrate binding site [chemical binding]; other site
391165003952	FAD binding domain; Region: FAD_binding_4; pfam01565
391165003953	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
391165003954	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
391165003955	FAD binding domain; Region: FAD_binding_4; pfam01565
391165003956	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
391165003957	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
391165003958	dimer interface [polypeptide binding]; other site
391165003959	active site
391165003960	metal binding site [ion binding]; metal-binding site
391165003961	glutathione binding site [chemical binding]; other site
391165003962	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
391165003963	Protein of unknown function (DUF983); Region: DUF983; cl02211
391165003964	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
391165003965	putative mechanosensitive channel protein; Provisional; Region: PRK11465
391165003966	Mechanosensitive ion channel; Region: MS_channel; pfam00924
391165003967	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
391165003968	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
391165003969	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
391165003970	glutaminase active site [active]
391165003971	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
391165003972	dimer interface [polypeptide binding]; other site
391165003973	active site
391165003974	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
391165003975	dimer interface [polypeptide binding]; other site
391165003976	active site
391165003977	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
391165003978	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
391165003979	Substrate binding site; other site
391165003980	Mg++ binding site; other site
391165003981	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
391165003982	active site
391165003983	substrate binding site [chemical binding]; other site
391165003984	CoA binding site [chemical binding]; other site
391165003985	2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449
391165003986	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165003987	motif II; other site
391165003988	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
391165003989	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
391165003990	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
391165003991	active site
391165003992	homotetramer interface [polypeptide binding]; other site
391165003993	Protein of unknown function (DUF989); Region: DUF989; pfam06181
391165003994	Predicted membrane protein [Function unknown]; Region: COG3748
391165003995	Cytochrome c; Region: Cytochrom_C; pfam00034
391165003996	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
391165003997	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
391165003998	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391165003999	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165004000	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391165004001	Preprotein translocase subunit; Region: YajC; pfam02699
391165004002	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
391165004003	Protein of unknown function (DUF815); Region: DUF815; pfam05673
391165004004	Peptidase family M48; Region: Peptidase_M48; cl12018
391165004005	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
391165004006	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
391165004007	oligomerization interface [polypeptide binding]; other site
391165004008	active site
391165004009	metal binding site [ion binding]; metal-binding site
391165004010	seryl-tRNA synthetase; Provisional; Region: PRK05431
391165004011	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
391165004012	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
391165004013	dimer interface [polypeptide binding]; other site
391165004014	active site
391165004015	motif 1; other site
391165004016	motif 2; other site
391165004017	motif 3; other site
391165004018	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
391165004019	sec-independent translocase; Provisional; Region: PRK00708
391165004020	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
391165004021	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
391165004022	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
391165004023	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
391165004024	Peptidase family M50; Region: Peptidase_M50; pfam02163
391165004025	active site
391165004026	putative substrate binding region [chemical binding]; other site
391165004027	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
391165004028	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
391165004029	Sporulation related domain; Region: SPOR; pfam05036
391165004030	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
391165004031	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
391165004032	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
391165004033	active site
391165004034	HIGH motif; other site
391165004035	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391165004036	KMSK motif region; other site
391165004037	tRNA binding surface [nucleotide binding]; other site
391165004038	DALR anticodon binding domain; Region: DALR_1; smart00836
391165004039	anticodon binding site; other site
391165004040	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
391165004041	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391165004042	Zn2+ binding site [ion binding]; other site
391165004043	Mg2+ binding site [ion binding]; other site
391165004044	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
391165004045	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
391165004046	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
391165004047	putative catalytic site [active]
391165004048	putative phosphate binding site [ion binding]; other site
391165004049	active site
391165004050	metal binding site A [ion binding]; metal-binding site
391165004051	DNA binding site [nucleotide binding]
391165004052	putative AP binding site [nucleotide binding]; other site
391165004053	putative metal binding site B [ion binding]; other site
391165004054	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
391165004055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165004056	putative substrate translocation pore; other site
391165004057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165004058	MFS transport protein AraJ; Provisional; Region: PRK10091
391165004059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165004060	putative substrate translocation pore; other site
391165004061	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
391165004062	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391165004063	substrate binding pocket [chemical binding]; other site
391165004064	membrane-bound complex binding site; other site
391165004065	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
391165004066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
391165004067	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
391165004068	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
391165004069	Walker A/P-loop; other site
391165004070	ATP binding site [chemical binding]; other site
391165004071	Q-loop/lid; other site
391165004072	ABC transporter signature motif; other site
391165004073	Walker B; other site
391165004074	D-loop; other site
391165004075	H-loop/switch region; other site
391165004076	Outer membrane efflux protein; Region: OEP; pfam02321
391165004077	Outer membrane efflux protein; Region: OEP; pfam02321
391165004078	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
391165004079	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
391165004080	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165004081	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
391165004082	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
391165004083	Subunit I/III interface [polypeptide binding]; other site
391165004084	Subunit III/IV interface [polypeptide binding]; other site
391165004085	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
391165004086	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
391165004087	D-pathway; other site
391165004088	Putative ubiquinol binding site [chemical binding]; other site
391165004089	Low-spin heme (heme b) binding site [chemical binding]; other site
391165004090	Putative water exit pathway; other site
391165004091	Binuclear center (heme o3/CuB) [ion binding]; other site
391165004092	K-pathway; other site
391165004093	Putative proton exit pathway; other site
391165004094	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
391165004095	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
391165004096	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
391165004097	elongation factor Ts; Provisional; Region: tsf; PRK09377
391165004098	UBA/TS-N domain; Region: UBA; pfam00627
391165004099	Elongation factor TS; Region: EF_TS; pfam00889
391165004100	Elongation factor TS; Region: EF_TS; pfam00889
391165004101	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
391165004102	rRNA interaction site [nucleotide binding]; other site
391165004103	S8 interaction site; other site
391165004104	putative laminin-1 binding site; other site
391165004105	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
391165004106	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
391165004107	putative active site [active]
391165004108	putative PHP Thumb interface [polypeptide binding]; other site
391165004109	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
391165004110	generic binding surface II; other site
391165004111	generic binding surface I; other site
391165004112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165004113	TPR repeat; Region: TPR_11; pfam13414
391165004114	binding surface
391165004115	TPR motif; other site
391165004116	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391165004117	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391165004118	Walker A/P-loop; other site
391165004119	ATP binding site [chemical binding]; other site
391165004120	Q-loop/lid; other site
391165004121	ABC transporter signature motif; other site
391165004122	Walker B; other site
391165004123	D-loop; other site
391165004124	H-loop/switch region; other site
391165004125	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
391165004126	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391165004127	FtsX-like permease family; Region: FtsX; pfam02687
391165004128	prolyl-tRNA synthetase; Provisional; Region: PRK12325
391165004129	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
391165004130	dimer interface [polypeptide binding]; other site
391165004131	motif 1; other site
391165004132	active site
391165004133	motif 2; other site
391165004134	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391165004135	active site
391165004136	motif 3; other site
391165004137	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
391165004138	anticodon binding site; other site
391165004139	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
391165004140	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
391165004141	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
391165004142	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
391165004143	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391165004144	nucleotide binding site [chemical binding]; other site
391165004145	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
391165004146	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
391165004147	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
391165004148	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
391165004149	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391165004150	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
391165004151	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391165004152	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
391165004153	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
391165004154	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
391165004155	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
391165004156	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
391165004157	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
391165004158	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
391165004159	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
391165004160	4Fe-4S binding domain; Region: Fer4; pfam00037
391165004161	4Fe-4S binding domain; Region: Fer4; pfam00037
391165004162	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
391165004163	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
391165004164	NADH dehydrogenase subunit G; Validated; Region: PRK09130
391165004165	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391165004166	catalytic loop [active]
391165004167	iron binding site [ion binding]; other site
391165004168	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
391165004169	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
391165004170	molybdopterin cofactor binding site; other site
391165004171	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
391165004172	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
391165004173	SLBB domain; Region: SLBB; pfam10531
391165004174	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
391165004175	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
391165004176	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
391165004177	putative dimer interface [polypeptide binding]; other site
391165004178	[2Fe-2S] cluster binding site [ion binding]; other site
391165004179	NADH dehydrogenase subunit D; Validated; Region: PRK06075
391165004180	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
391165004181	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
391165004182	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
391165004183	NADH dehydrogenase subunit B; Validated; Region: PRK06411
391165004184	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
391165004185	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
391165004186	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
391165004187	IHF dimer interface [polypeptide binding]; other site
391165004188	IHF - DNA interface [nucleotide binding]; other site
391165004189	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
391165004190	Found in ATP-dependent protease La (LON); Region: LON; smart00464
391165004191	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165004192	Walker A motif; other site
391165004193	ATP binding site [chemical binding]; other site
391165004194	Walker B motif; other site
391165004195	arginine finger; other site
391165004196	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
391165004197	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
391165004198	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
391165004199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165004200	Walker A motif; other site
391165004201	ATP binding site [chemical binding]; other site
391165004202	Walker B motif; other site
391165004203	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
391165004204	Clp protease; Region: CLP_protease; pfam00574
391165004205	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
391165004206	oligomer interface [polypeptide binding]; other site
391165004207	active site residues [active]
391165004208	trigger factor; Provisional; Region: tig; PRK01490
391165004209	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391165004210	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
391165004211	Uncharacterized conserved protein [Function unknown]; Region: COG0062
391165004212	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
391165004213	putative substrate binding site [chemical binding]; other site
391165004214	putative ATP binding site [chemical binding]; other site
391165004215	Predicted integral membrane protein [Function unknown]; Region: COG5615
391165004216	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
391165004217	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
391165004218	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
391165004219	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165004220	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
391165004221	Protein export membrane protein; Region: SecD_SecF; cl14618
391165004222	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
391165004223	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
391165004224	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
391165004225	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297
391165004226	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
391165004227	ATP binding site [chemical binding]; other site
391165004228	Mg++ binding site [ion binding]; other site
391165004229	motif III; other site
391165004230	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165004231	nucleotide binding region [chemical binding]; other site
391165004232	ATP-binding site [chemical binding]; other site
391165004233	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
391165004234	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
391165004235	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
391165004236	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
391165004237	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
391165004238	trimerization site [polypeptide binding]; other site
391165004239	active site
391165004240	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
391165004241	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
391165004242	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391165004243	catalytic residue [active]
391165004244	FeS assembly protein SufD; Region: sufD; TIGR01981
391165004245	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
391165004246	FeS assembly ATPase SufC; Region: sufC; TIGR01978
391165004247	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
391165004248	Walker A/P-loop; other site
391165004249	ATP binding site [chemical binding]; other site
391165004250	Q-loop/lid; other site
391165004251	ABC transporter signature motif; other site
391165004252	Walker B; other site
391165004253	D-loop; other site
391165004254	H-loop/switch region; other site
391165004255	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
391165004256	putative ABC transporter; Region: ycf24; CHL00085
391165004257	Transcriptional regulator; Region: Rrf2; pfam02082
391165004258	Uncharacterized secreted protein [Function unknown]; Region: COG5430
391165004259	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
391165004260	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
391165004261	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
391165004262	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
391165004263	PapC C-terminal domain; Region: PapC_C; pfam13953
391165004264	Spore Coat Protein U domain; Region: SCPU; pfam05229
391165004265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165004266	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391165004267	putative substrate translocation pore; other site
391165004268	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
391165004269	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
391165004270	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
391165004271	Protein of unknown function (DUF445); Region: DUF445; pfam04286
391165004272	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391165004273	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391165004274	elongation factor G; Reviewed; Region: PRK12739
391165004275	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
391165004276	G1 box; other site
391165004277	putative GEF interaction site [polypeptide binding]; other site
391165004278	GTP/Mg2+ binding site [chemical binding]; other site
391165004279	Switch I region; other site
391165004280	G2 box; other site
391165004281	G3 box; other site
391165004282	Switch II region; other site
391165004283	G4 box; other site
391165004284	G5 box; other site
391165004285	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
391165004286	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
391165004287	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
391165004288	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
391165004289	active site
391165004290	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391165004291	endonuclease III; Region: ENDO3c; smart00478
391165004292	minor groove reading motif; other site
391165004293	helix-hairpin-helix signature motif; other site
391165004294	substrate binding pocket [chemical binding]; other site
391165004295	active site
391165004296	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
391165004297	folate binding site [chemical binding]; other site
391165004298	NADP+ binding site [chemical binding]; other site
391165004299	Hint domain; Region: Hint_2; pfam13403
391165004300	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391165004301	PGAP1-like protein; Region: PGAP1; pfam07819
391165004302	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
391165004303	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
391165004304	NAD(P) binding site [chemical binding]; other site
391165004305	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
391165004306	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
391165004307	Cl- selectivity filter; other site
391165004308	Cl- binding residues [ion binding]; other site
391165004309	pore gating glutamate residue; other site
391165004310	dimer interface [polypeptide binding]; other site
391165004311	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
391165004312	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
391165004313	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
391165004314	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
391165004315	FOG: CBS domain [General function prediction only]; Region: COG0517
391165004316	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
391165004317	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
391165004318	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
391165004319	N-terminal domain interface [polypeptide binding]; other site
391165004320	dimer interface [polypeptide binding]; other site
391165004321	substrate binding pocket (H-site) [chemical binding]; other site
391165004322	pyridoxamine kinase; Validated; Region: PRK05756
391165004323	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
391165004324	dimer interface [polypeptide binding]; other site
391165004325	pyridoxal binding site [chemical binding]; other site
391165004326	ATP binding site [chemical binding]; other site
391165004327	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
391165004328	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
391165004329	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
391165004330	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
391165004331	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
391165004332	putative dimer interface [polypeptide binding]; other site
391165004333	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
391165004334	MgtC family; Region: MgtC; pfam02308
391165004335	Protein of unknown function (DUF1192); Region: DUF1192; pfam06698
391165004336	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
391165004337	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
391165004338	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
391165004339	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
391165004340	ATP-grasp domain; Region: ATP-grasp; pfam02222
391165004341	isocitrate dehydrogenase; Validated; Region: PRK08299
391165004342	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
391165004343	Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705
391165004344	Proteolipid membrane potential modulator; Region: Pmp3; cl00431
391165004345	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
391165004346	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
391165004347	motif 1; other site
391165004348	active site
391165004349	motif 2; other site
391165004350	motif 3; other site
391165004351	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
391165004352	putative ssRNA endonuclease; Provisional; Region: PRK11558
391165004353	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
391165004354	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
391165004355	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
391165004356	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
391165004357	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
391165004358	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
391165004359	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
391165004360	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
391165004361	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
391165004362	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391165004363	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
391165004364	active site
391165004365	catalytic motif [active]
391165004366	Zn binding site [ion binding]; other site
391165004367	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
391165004368	recombinase A; Provisional; Region: recA; PRK09354
391165004369	hexamer interface [polypeptide binding]; other site
391165004370	Walker A motif; other site
391165004371	ATP binding site [chemical binding]; other site
391165004372	Walker B motif; other site
391165004373	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
391165004374	spermidine synthase; Provisional; Region: PRK00811
391165004375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165004376	S-adenosylmethionine binding site [chemical binding]; other site
391165004377	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
391165004378	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165004379	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
391165004380	hypothetical protein; Provisional; Region: PRK02853
391165004381	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
391165004382	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
391165004383	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
391165004384	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
391165004385	active site residue [active]
391165004386	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
391165004387	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
391165004388	dimer interface [polypeptide binding]; other site
391165004389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165004390	catalytic residue [active]
391165004391	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
391165004392	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
391165004393	putative active site [active]
391165004394	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
391165004395	DHH family; Region: DHH; pfam01368
391165004396	DHHA1 domain; Region: DHHA1; pfam02272
391165004397	Protein of unknown function, DUF606; Region: DUF606; pfam04657
391165004398	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
391165004399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165004400	S-adenosylmethionine binding site [chemical binding]; other site
391165004401	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
391165004402	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
391165004403	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
391165004404	structural tetrad; other site
391165004405	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
391165004406	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
391165004407	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
391165004408	putative hydrophobic ligand binding site [chemical binding]; other site
391165004409	protein interface [polypeptide binding]; other site
391165004410	gate; other site
391165004411	Hint domain; Region: Hint_2; pfam13403
391165004412	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
391165004413	catalytic core [active]
391165004414	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
391165004415	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
391165004416	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391165004417	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
391165004418	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
391165004419	transcription elongation factor regulatory protein; Validated; Region: PRK06342
391165004420	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
391165004421	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
391165004422	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391165004423	active site
391165004424	HIGH motif; other site
391165004425	nucleotide binding site [chemical binding]; other site
391165004426	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391165004427	active site
391165004428	KMSKS motif; other site
391165004429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
391165004430	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
391165004431	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
391165004432	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
391165004433	active site
391165004434	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
391165004435	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
391165004436	Cache domain; Region: Cache_1; pfam02743
391165004437	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
391165004438	GAF domain; Region: GAF; pfam01590
391165004439	cyclase homology domain; Region: CHD; cd07302
391165004440	dimer interface [polypeptide binding]; other site
391165004441	nucleotidyl binding site; other site
391165004442	metal binding site [ion binding]; metal-binding site
391165004443	Permease; Region: Permease; pfam02405
391165004444	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165004445	Q-loop/lid; other site
391165004446	ABC transporter signature motif; other site
391165004447	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
391165004448	mce related protein; Region: MCE; pfam02470
391165004449	glutathione reductase; Validated; Region: PRK06116
391165004450	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391165004451	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165004452	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391165004453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391165004454	psiF repeat; Region: PsiF_repeat; pfam07769
391165004455	psiF repeat; Region: PsiF_repeat; pfam07769
391165004456	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
391165004457	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
391165004458	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
391165004459	ligand binding site [chemical binding]; other site
391165004460	homoserine dehydrogenase; Provisional; Region: PRK06349
391165004461	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
391165004462	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
391165004463	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
391165004464	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
391165004465	Beta-lactamase; Region: Beta-lactamase; pfam00144
391165004466	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
391165004467	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
391165004468	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391165004469	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391165004470	catalytic residue [active]
391165004471	Sporulation related domain; Region: SPOR; pfam05036
391165004472	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
391165004473	Predicted amidohydrolase [General function prediction only]; Region: COG0388
391165004474	putative active site [active]
391165004475	catalytic triad [active]
391165004476	putative dimer interface [polypeptide binding]; other site
391165004477	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
391165004478	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
391165004479	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
391165004480	Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059
391165004481	calcium binding site 1 [ion binding]; other site
391165004482	active site
391165004483	catalytic triad [active]
391165004484	calcium binding site 2 [ion binding]; other site
391165004485	calcium binding site 3 [ion binding]; other site
391165004486	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
391165004487	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
391165004488	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
391165004489	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
391165004490	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
391165004491	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
391165004492	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
391165004493	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
391165004494	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
391165004495	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
391165004496	Protein export membrane protein; Region: SecD_SecF; pfam02355
391165004497	Predicted membrane protein [Function unknown]; Region: COG2246
391165004498	GtrA-like protein; Region: GtrA; pfam04138
391165004499	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
391165004500	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391165004501	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
391165004502	Ligand binding site; other site
391165004503	Putative Catalytic site; other site
391165004504	DXD motif; other site
391165004505	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
391165004506	Permease; Region: Permease; pfam02405
391165004507	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391165004508	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165004509	Walker A/P-loop; other site
391165004510	ATP binding site [chemical binding]; other site
391165004511	Q-loop/lid; other site
391165004512	ABC transporter signature motif; other site
391165004513	Walker B; other site
391165004514	D-loop; other site
391165004515	H-loop/switch region; other site
391165004516	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
391165004517	mce related protein; Region: MCE; pfam02470
391165004518	Protein of unknown function (DUF330); Region: DUF330; pfam03886
391165004519	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
391165004520	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391165004521	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391165004522	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
391165004523	Protein of unknown function (DUF3649); Region: DUF3649; pfam12365
391165004524	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
391165004525	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
391165004526	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
391165004527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165004528	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391165004529	putative substrate translocation pore; other site
391165004530	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
391165004531	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391165004532	HSP70 interaction site [polypeptide binding]; other site
391165004533	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
391165004534	substrate binding site [polypeptide binding]; other site
391165004535	dimer interface [polypeptide binding]; other site
391165004536	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
391165004537	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
391165004538	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
391165004539	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
391165004540	Ligand binding site; other site
391165004541	Putative Catalytic site; other site
391165004542	DXD motif; other site
391165004543	Predicted membrane protein [Function unknown]; Region: COG2246
391165004544	GtrA-like protein; Region: GtrA; pfam04138
391165004545	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
391165004546	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
391165004547	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
391165004548	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
391165004549	rod shape-determining protein MreC; Provisional; Region: PRK13922
391165004550	rod shape-determining protein MreC; Region: MreC; pfam04085
391165004551	rod shape-determining protein MreB; Provisional; Region: PRK13927
391165004552	MreB and similar proteins; Region: MreB_like; cd10225
391165004553	nucleotide binding site [chemical binding]; other site
391165004554	Mg binding site [ion binding]; other site
391165004555	putative protofilament interaction site [polypeptide binding]; other site
391165004556	RodZ interaction site [polypeptide binding]; other site
391165004557	2-isopropylmalate synthase; Validated; Region: PRK00915
391165004558	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
391165004559	active site
391165004560	catalytic residues [active]
391165004561	metal binding site [ion binding]; metal-binding site
391165004562	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
391165004563	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165004564	non-specific DNA binding site [nucleotide binding]; other site
391165004565	salt bridge; other site
391165004566	sequence-specific DNA binding site [nucleotide binding]; other site
391165004567	Predicted transcriptional regulator [Transcription]; Region: COG2932
391165004568	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
391165004569	Catalytic site [active]
391165004570	Hint domain; Region: Hint_2; pfam13403
391165004571	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
391165004572	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
391165004573	ketol-acid reductoisomerase; Provisional; Region: PRK05479
391165004574	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
391165004575	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
391165004576	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
391165004577	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
391165004578	putative valine binding site [chemical binding]; other site
391165004579	dimer interface [polypeptide binding]; other site
391165004580	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
391165004581	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
391165004582	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
391165004583	PYR/PP interface [polypeptide binding]; other site
391165004584	dimer interface [polypeptide binding]; other site
391165004585	TPP binding site [chemical binding]; other site
391165004586	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
391165004587	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
391165004588	TPP-binding site [chemical binding]; other site
391165004589	dimer interface [polypeptide binding]; other site
391165004590	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
391165004591	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
391165004592	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
391165004593	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165004594	motif II; other site
391165004595	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
391165004596	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
391165004597	Walker A/P-loop; other site
391165004598	ATP binding site [chemical binding]; other site
391165004599	Q-loop/lid; other site
391165004600	ABC transporter signature motif; other site
391165004601	Walker B; other site
391165004602	D-loop; other site
391165004603	H-loop/switch region; other site
391165004604	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
391165004605	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
391165004606	putative ligand binding site [chemical binding]; other site
391165004607	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
391165004608	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
391165004609	TM-ABC transporter signature motif; other site
391165004610	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
391165004611	TM-ABC transporter signature motif; other site
391165004612	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
391165004613	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
391165004614	Walker A/P-loop; other site
391165004615	ATP binding site [chemical binding]; other site
391165004616	Q-loop/lid; other site
391165004617	ABC transporter signature motif; other site
391165004618	Walker B; other site
391165004619	D-loop; other site
391165004620	H-loop/switch region; other site
391165004621	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
391165004622	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
391165004623	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
391165004624	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391165004625	protein binding site [polypeptide binding]; other site
391165004626	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391165004627	protein binding site [polypeptide binding]; other site
391165004628	Domain of unknown function DUF59; Region: DUF59; pfam01883
391165004629	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
391165004630	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
391165004631	Walker A motif; other site
391165004632	PAS fold; Region: PAS_2; pfam08446
391165004633	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
391165004634	GAF domain; Region: GAF; pfam01590
391165004635	Phytochrome region; Region: PHY; pfam00360
391165004636	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
391165004637	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
391165004638	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
391165004639	N-terminal plug; other site
391165004640	ligand-binding site [chemical binding]; other site
391165004641	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165004642	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165004643	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
391165004644	putative dimerization interface [polypeptide binding]; other site
391165004645	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
391165004646	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
391165004647	gating phenylalanine in ion channel; other site
391165004648	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
391165004649	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
391165004650	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
391165004651	P loop; other site
391165004652	GTP binding site [chemical binding]; other site
391165004653	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
391165004654	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
391165004655	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165004656	FeS/SAM binding site; other site
391165004657	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
391165004658	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
391165004659	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
391165004660	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
391165004661	active site
391165004662	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
391165004663	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
391165004664	23S rRNA binding site [nucleotide binding]; other site
391165004665	L21 binding site [polypeptide binding]; other site
391165004666	L13 binding site [polypeptide binding]; other site
391165004667	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
391165004668	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
391165004669	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
391165004670	dimer interface [polypeptide binding]; other site
391165004671	motif 1; other site
391165004672	active site
391165004673	motif 2; other site
391165004674	motif 3; other site
391165004675	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
391165004676	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
391165004677	putative tRNA-binding site [nucleotide binding]; other site
391165004678	B3/4 domain; Region: B3_4; pfam03483
391165004679	tRNA synthetase B5 domain; Region: B5; smart00874
391165004680	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
391165004681	dimer interface [polypeptide binding]; other site
391165004682	motif 1; other site
391165004683	motif 3; other site
391165004684	motif 2; other site
391165004685	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
391165004686	GTP-binding protein LepA; Provisional; Region: PRK05433
391165004687	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
391165004688	G1 box; other site
391165004689	putative GEF interaction site [polypeptide binding]; other site
391165004690	GTP/Mg2+ binding site [chemical binding]; other site
391165004691	Switch I region; other site
391165004692	G2 box; other site
391165004693	G3 box; other site
391165004694	Switch II region; other site
391165004695	G4 box; other site
391165004696	G5 box; other site
391165004697	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
391165004698	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
391165004699	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
391165004700	integrase; Provisional; Region: PRK09692
391165004701	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
391165004702	active site
391165004703	Int/Topo IB signature motif; other site
391165004704	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391165004705	AAA-like domain; Region: AAA_10; pfam12846
391165004706	Walker A motif; other site
391165004707	ATP binding site [chemical binding]; other site
391165004708	Walker B motif; other site
391165004709	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391165004710	TrwC relaxase; Region: TrwC; pfam08751
391165004711	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
391165004712	Family description; Region: UvrD_C_2; pfam13538
391165004713	Methyltransferase domain; Region: Methyltransf_26; pfam13659
391165004714	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
391165004715	HicB family; Region: HicB; pfam05534
391165004716	DEAD-like helicases superfamily; Region: DEXDc; smart00487
391165004717	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391165004718	ATP binding site [chemical binding]; other site
391165004719	putative Mg++ binding site [ion binding]; other site
391165004720	Pseudomurein-binding repeat; Region: PMBR; pfam09373
391165004721	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
391165004722	Beta protein; Region: Beta_protein; pfam14350
391165004723	Domain of unknown function (DUF955); Region: DUF955; pfam06114
391165004724	Class I aldolases; Region: Aldolase_Class_I; cl17187
391165004725	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
391165004726	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165004727	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
391165004728	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
391165004729	putative active site [active]
391165004730	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391165004731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165004732	Walker A/P-loop; other site
391165004733	ATP binding site [chemical binding]; other site
391165004734	Q-loop/lid; other site
391165004735	ABC transporter signature motif; other site
391165004736	Walker B; other site
391165004737	D-loop; other site
391165004738	H-loop/switch region; other site
391165004739	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
391165004740	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391165004741	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165004742	Walker A/P-loop; other site
391165004743	ATP binding site [chemical binding]; other site
391165004744	Q-loop/lid; other site
391165004745	ABC transporter signature motif; other site
391165004746	Walker B; other site
391165004747	D-loop; other site
391165004748	H-loop/switch region; other site
391165004749	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
391165004750	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
391165004751	Fe-S cluster binding site [ion binding]; other site
391165004752	active site
391165004753	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
391165004754	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165004755	FeS/SAM binding site; other site
391165004756	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
391165004757	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
391165004758	NADP binding site [chemical binding]; other site
391165004759	homopentamer interface [polypeptide binding]; other site
391165004760	substrate binding site [chemical binding]; other site
391165004761	active site
391165004762	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
391165004763	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
391165004764	putative active site [active]
391165004765	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
391165004766	putative ligand binding site [chemical binding]; other site
391165004767	putative catalytic site [active]
391165004768	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
391165004769	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
391165004770	dimer interface [polypeptide binding]; other site
391165004771	active site
391165004772	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
391165004773	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
391165004774	NAD(P) binding site [chemical binding]; other site
391165004775	catalytic residues [active]
391165004776	Hint domain; Region: Hint_2; pfam13403
391165004777	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
391165004778	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
391165004779	Probable Catalytic site; other site
391165004780	metal-binding site
391165004781	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165004782	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
391165004783	camphor resistance protein CrcB; Provisional; Region: PRK14198
391165004784	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
391165004785	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
391165004786	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
391165004787	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165004788	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391165004789	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391165004790	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
391165004791	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
391165004792	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
391165004793	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
391165004794	catalytic site [active]
391165004795	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
391165004796	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
391165004797	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
391165004798	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
391165004799	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
391165004800	Orbivirus outer capsid protein VP5; Region: Orbi_VP5; pfam00901
391165004801	Orbivirus outer capsid protein VP5; Region: Orbi_VP5; pfam00901
391165004802	isoleucine-tRNA ligase, putative; Provisional; Region: PTZ00427
391165004803	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
391165004804	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
391165004805	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
391165004806	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
391165004807	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
391165004808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
391165004809	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
391165004810	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
391165004811	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
391165004812	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
391165004813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
391165004814	Terminase-like family; Region: Terminase_6; pfam03237
391165004815	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
391165004816	Terminase small subunit; Region: Terminase_2; cl01513
391165004817	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
391165004818	Cytochrome c; Region: Cytochrom_C; pfam00034
391165004819	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
391165004820	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
391165004821	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165004822	non-specific DNA binding site [nucleotide binding]; other site
391165004823	salt bridge; other site
391165004824	Predicted transcriptional regulator [Transcription]; Region: COG2932
391165004825	sequence-specific DNA binding site [nucleotide binding]; other site
391165004826	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
391165004827	Catalytic site [active]
391165004828	PIN domain; Region: PIN_3; pfam13470
391165004829	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
391165004830	NADH(P)-binding; Region: NAD_binding_10; pfam13460
391165004831	NAD binding site [chemical binding]; other site
391165004832	substrate binding site [chemical binding]; other site
391165004833	putative active site [active]
391165004834	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
391165004835	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
391165004836	heme binding pocket [chemical binding]; other site
391165004837	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
391165004838	domain interactions; other site
391165004839	choline dehydrogenase; Validated; Region: PRK02106
391165004840	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
391165004841	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
391165004842	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
391165004843	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
391165004844	NAD(P) binding site [chemical binding]; other site
391165004845	catalytic residues [active]
391165004846	transcriptional regulator BetI; Validated; Region: PRK00767
391165004847	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391165004848	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
391165004849	signal recognition particle protein; Provisional; Region: PRK10867
391165004850	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
391165004851	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391165004852	Signal peptide binding domain; Region: SRP_SPB; pfam02978
391165004853	Hint domain; Region: Hint_2; pfam13403
391165004854	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
391165004855	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
391165004856	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
391165004857	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
391165004858	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
391165004859	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
391165004860	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
391165004861	active site
391165004862	dimer interface [polypeptide binding]; other site
391165004863	motif 1; other site
391165004864	motif 2; other site
391165004865	motif 3; other site
391165004866	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
391165004867	anticodon binding site; other site
391165004868	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
391165004869	putative heme binding pocket [chemical binding]; other site
391165004870	Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059
391165004871	calcium binding site 1 [ion binding]; other site
391165004872	active site
391165004873	catalytic triad [active]
391165004874	calcium binding site 2 [ion binding]; other site
391165004875	calcium binding site 3 [ion binding]; other site
391165004876	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
391165004877	Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462
391165004878	hypothetical protein; Provisional; Region: PRK09946
391165004879	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
391165004880	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
391165004881	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
391165004882	G1 box; other site
391165004883	GTP/Mg2+ binding site [chemical binding]; other site
391165004884	Switch I region; other site
391165004885	G2 box; other site
391165004886	G3 box; other site
391165004887	Switch II region; other site
391165004888	G4 box; other site
391165004889	G5 box; other site
391165004890	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
391165004891	Nucleoside recognition; Region: Gate; pfam07670
391165004892	Nucleoside recognition; Region: Gate; pfam07670
391165004893	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
391165004894	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
391165004895	Cl binding site [ion binding]; other site
391165004896	oligomer interface [polypeptide binding]; other site
391165004897	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
391165004898	hypothetical protein; Provisional; Region: PRK10621
391165004899	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
391165004900	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
391165004901	Spore germination protein GerPC; Region: GerPC; pfam10737
391165004902	Uncharacterized conserved protein [Function unknown]; Region: COG2353
391165004903	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
391165004904	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
391165004905	NAD binding site [chemical binding]; other site
391165004906	homodimer interface [polypeptide binding]; other site
391165004907	active site
391165004908	substrate binding site [chemical binding]; other site
391165004909	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
391165004910	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391165004911	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391165004912	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165004913	Walker A/P-loop; other site
391165004914	ATP binding site [chemical binding]; other site
391165004915	Q-loop/lid; other site
391165004916	ABC transporter signature motif; other site
391165004917	Walker B; other site
391165004918	D-loop; other site
391165004919	H-loop/switch region; other site
391165004920	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
391165004921	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
391165004922	active site
391165004923	NTP binding site [chemical binding]; other site
391165004924	metal binding triad [ion binding]; metal-binding site
391165004925	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
391165004926	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
391165004927	putative active site [active]
391165004928	putative CoA binding site [chemical binding]; other site
391165004929	nudix motif; other site
391165004930	metal binding site [ion binding]; metal-binding site
391165004931	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
391165004932	xanthine permease; Region: pbuX; TIGR03173
391165004933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165004934	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165004935	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
391165004936	dimerization interface [polypeptide binding]; other site
391165004937	MoxR-like ATPases [General function prediction only]; Region: COG0714
391165004938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
391165004939	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
391165004940	Protein of unknown function DUF58; Region: DUF58; pfam01882
391165004941	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
391165004942	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391165004943	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
391165004944	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
391165004945	TspO/MBR family; Region: TspO_MBR; pfam03073
391165004946	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
391165004947	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391165004948	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
391165004949	non-specific DNA interactions [nucleotide binding]; other site
391165004950	DNA binding site [nucleotide binding]
391165004951	putative cAMP binding site [chemical binding]; other site
391165004952	sequence specific DNA binding site [nucleotide binding]; other site
391165004953	Hint domain; Region: Hint_2; pfam13403
391165004954	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391165004955	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
391165004956	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
391165004957	purine monophosphate binding site [chemical binding]; other site
391165004958	dimer interface [polypeptide binding]; other site
391165004959	putative catalytic residues [active]
391165004960	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
391165004961	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
391165004962	Uncharacterized conserved protein [Function unknown]; Region: COG2127
391165004963	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
391165004964	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
391165004965	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
391165004966	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165004967	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
391165004968	active site
391165004969	hypothetical protein; Reviewed; Region: PRK00024
391165004970	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
391165004971	MPN+ (JAMM) motif; other site
391165004972	Zinc-binding site [ion binding]; other site
391165004973	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165004974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165004975	active site
391165004976	phosphorylation site [posttranslational modification]
391165004977	intermolecular recognition site; other site
391165004978	dimerization interface [polypeptide binding]; other site
391165004979	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165004980	DNA binding site [nucleotide binding]
391165004981	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
391165004982	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
391165004983	dimerization interface [polypeptide binding]; other site
391165004984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165004985	dimer interface [polypeptide binding]; other site
391165004986	phosphorylation site [posttranslational modification]
391165004987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165004988	ATP binding site [chemical binding]; other site
391165004989	Mg2+ binding site [ion binding]; other site
391165004990	G-X-G motif; other site
391165004991	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
391165004992	adenylosuccinate lyase; Provisional; Region: PRK07492
391165004993	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
391165004994	tetramer interface [polypeptide binding]; other site
391165004995	active site
391165004996	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
391165004997	NRDE protein; Region: NRDE; cl01315
391165004998	haemagglutination activity domain; Region: Haemagg_act; pfam05860
391165004999	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
391165005000	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
391165005001	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
391165005002	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
391165005003	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
391165005004	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
391165005005	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
391165005006	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
391165005007	ATP binding site [chemical binding]; other site
391165005008	active site
391165005009	substrate binding site [chemical binding]; other site
391165005010	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
391165005011	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
391165005012	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
391165005013	putative active site [active]
391165005014	catalytic triad [active]
391165005015	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
391165005016	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
391165005017	dimerization interface [polypeptide binding]; other site
391165005018	ATP binding site [chemical binding]; other site
391165005019	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
391165005020	dimerization interface [polypeptide binding]; other site
391165005021	ATP binding site [chemical binding]; other site
391165005022	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
391165005023	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
391165005024	putative GSH binding site [chemical binding]; other site
391165005025	catalytic residues [active]
391165005026	Transcriptional regulator; Region: Rrf2; cl17282
391165005027	Rrf2 family protein; Region: rrf2_super; TIGR00738
391165005028	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
391165005029	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
391165005030	heme-binding site [chemical binding]; other site
391165005031	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
391165005032	FAD binding pocket [chemical binding]; other site
391165005033	FAD binding motif [chemical binding]; other site
391165005034	phosphate binding motif [ion binding]; other site
391165005035	beta-alpha-beta structure motif; other site
391165005036	NAD binding pocket [chemical binding]; other site
391165005037	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
391165005038	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
391165005039	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
391165005040	dimer interface [polypeptide binding]; other site
391165005041	active site
391165005042	heme binding site [chemical binding]; other site
391165005043	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
391165005044	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
391165005045	tartrate dehydrogenase; Region: TTC; TIGR02089
391165005046	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
391165005047	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
391165005048	substrate binding site [chemical binding]; other site
391165005049	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
391165005050	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
391165005051	substrate binding site [chemical binding]; other site
391165005052	ligand binding site [chemical binding]; other site
391165005053	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
391165005054	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
391165005055	RimM N-terminal domain; Region: RimM; pfam01782
391165005056	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
391165005057	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
391165005058	FMN-binding domain; Region: FMN_bind; pfam04205
391165005059	ApbE family; Region: ApbE; pfam02424
391165005060	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
391165005061	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
391165005062	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
391165005063	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
391165005064	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391165005065	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
391165005066	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
391165005067	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
391165005068	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
391165005069	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
391165005070	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
391165005071	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
391165005072	CRISPR-associated protein (Cas_Cas2CT1978); Region: Cas_Cas2CT1978; pfam09707
391165005073	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
391165005074	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
391165005075	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
391165005076	GTPase CgtA; Reviewed; Region: obgE; PRK12299
391165005077	GTP1/OBG; Region: GTP1_OBG; pfam01018
391165005078	Obg GTPase; Region: Obg; cd01898
391165005079	G1 box; other site
391165005080	GTP/Mg2+ binding site [chemical binding]; other site
391165005081	Switch I region; other site
391165005082	G2 box; other site
391165005083	G3 box; other site
391165005084	Switch II region; other site
391165005085	G4 box; other site
391165005086	G5 box; other site
391165005087	gamma-glutamyl kinase; Provisional; Region: PRK05429
391165005088	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
391165005089	nucleotide binding site [chemical binding]; other site
391165005090	homotetrameric interface [polypeptide binding]; other site
391165005091	putative phosphate binding site [ion binding]; other site
391165005092	putative allosteric binding site; other site
391165005093	PUA domain; Region: PUA; pfam01472
391165005094	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
391165005095	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
391165005096	putative catalytic cysteine [active]
391165005097	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
391165005098	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
391165005099	active site
391165005100	(T/H)XGH motif; other site
391165005101	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
391165005102	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
391165005103	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
391165005104	phosphoglyceromutase; Provisional; Region: PRK05434
391165005105	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
391165005106	Peptidase family M23; Region: Peptidase_M23; pfam01551
391165005107	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
391165005108	C-terminal peptidase (prc); Region: prc; TIGR00225
391165005109	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
391165005110	protein binding site [polypeptide binding]; other site
391165005111	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
391165005112	Catalytic dyad [active]
391165005113	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
391165005114	putative active site [active]
391165005115	Ap4A binding site [chemical binding]; other site
391165005116	nudix motif; other site
391165005117	putative metal binding site [ion binding]; other site
391165005118	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
391165005119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165005120	NAD(P) binding site [chemical binding]; other site
391165005121	active site
391165005122	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
391165005123	putative deacylase active site [active]
391165005124	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
391165005125	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
391165005126	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
391165005127	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
391165005128	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
391165005129	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
391165005130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165005131	putative substrate translocation pore; other site
391165005132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165005133	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
391165005134	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
391165005135	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165005136	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
391165005137	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
391165005138	[4Fe-4S] binding site [ion binding]; other site
391165005139	molybdopterin cofactor binding site; other site
391165005140	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
391165005141	molybdopterin cofactor binding site; other site
391165005142	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
391165005143	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
391165005144	[2Fe-2S] cluster binding site [ion binding]; other site
391165005145	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
391165005146	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165005147	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
391165005148	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
391165005149	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
391165005150	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
391165005151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165005152	putative substrate translocation pore; other site
391165005153	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
391165005154	NMT1-like family; Region: NMT1_2; pfam13379
391165005155	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
391165005156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
391165005157	active site
391165005158	phosphorylation site [posttranslational modification]
391165005159	intermolecular recognition site; other site
391165005160	dimerization interface [polypeptide binding]; other site
391165005161	ANTAR domain; Region: ANTAR; pfam03861
391165005162	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
391165005163	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
391165005164	active site
391165005165	homotetramer interface [polypeptide binding]; other site
391165005166	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
391165005167	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165005168	active site
391165005169	motif I; other site
391165005170	motif II; other site
391165005171	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
391165005172	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
391165005173	mce related protein; Region: MCE; pfam02470
391165005174	NADH dehydrogenase; Validated; Region: PRK08183
391165005175	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
391165005176	TSCPD domain; Region: TSCPD; pfam12637
391165005177	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
391165005178	homotrimer interaction site [polypeptide binding]; other site
391165005179	putative active site [active]
391165005180	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
391165005181	Protein of unknown function, DUF482; Region: DUF482; pfam04339
391165005182	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
391165005183	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
391165005184	putative catalytic site [active]
391165005185	putative metal binding site [ion binding]; other site
391165005186	putative phosphate binding site [ion binding]; other site
391165005187	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
391165005188	malonic semialdehyde reductase; Provisional; Region: PRK10538
391165005189	putative NAD(P) binding site [chemical binding]; other site
391165005190	homodimer interface [polypeptide binding]; other site
391165005191	homotetramer interface [polypeptide binding]; other site
391165005192	active site
391165005193	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
391165005194	allophanate hydrolase; Provisional; Region: PRK08186
391165005195	Amidase; Region: Amidase; cl11426
391165005196	urea carboxylase; Region: urea_carbox; TIGR02712
391165005197	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391165005198	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391165005199	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
391165005200	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
391165005201	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
391165005202	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
391165005203	carboxyltransferase (CT) interaction site; other site
391165005204	biotinylation site [posttranslational modification]; other site
391165005205	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
391165005206	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
391165005207	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
391165005208	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
391165005209	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391165005210	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
391165005211	Walker A/P-loop; other site
391165005212	ATP binding site [chemical binding]; other site
391165005213	Q-loop/lid; other site
391165005214	ABC transporter signature motif; other site
391165005215	Walker B; other site
391165005216	D-loop; other site
391165005217	H-loop/switch region; other site
391165005218	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
391165005219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165005220	dimer interface [polypeptide binding]; other site
391165005221	conserved gate region; other site
391165005222	putative PBP binding loops; other site
391165005223	ABC-ATPase subunit interface; other site
391165005224	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
391165005225	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
391165005226	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
391165005227	Clp amino terminal domain; Region: Clp_N; pfam02861
391165005228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165005229	Walker A motif; other site
391165005230	ATP binding site [chemical binding]; other site
391165005231	Walker B motif; other site
391165005232	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
391165005233	arginine finger; other site
391165005234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165005235	Walker A motif; other site
391165005236	ATP binding site [chemical binding]; other site
391165005237	Walker B motif; other site
391165005238	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
391165005239	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165005240	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
391165005241	putative ADP-binding pocket [chemical binding]; other site
391165005242	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
391165005243	NusB family; Region: NusB; pfam01029
391165005244	putative RNA binding site [nucleotide binding]; other site
391165005245	16S rRNA methyltransferase B; Provisional; Region: PRK10901
391165005246	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
391165005247	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
391165005248	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
391165005249	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
391165005250	type II secretion system protein E; Region: type_II_gspE; TIGR02533
391165005251	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
391165005252	Walker A motif; other site
391165005253	ATP binding site [chemical binding]; other site
391165005254	Walker B motif; other site
391165005255	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
391165005256	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
391165005257	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
391165005258	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
391165005259	Type II transport protein GspH; Region: GspH; pfam12019
391165005260	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
391165005261	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
391165005262	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
391165005263	Catalytic domain of uncharacterized hypothetical proteins similar to eukaryotic phosphatidylinositol-specific phospholipase C, X domain containing proteins; Region: PI-PLCXDc_like_1; cd08620
391165005264	putative active site [active]
391165005265	catalytic site [active]
391165005266	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
391165005267	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
391165005268	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
391165005269	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
391165005270	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
391165005271	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
391165005272	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
391165005273	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391165005274	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391165005275	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391165005276	substrate binding pocket [chemical binding]; other site
391165005277	Ligand-gated ion channel; Region: Lig_chan; pfam00060
391165005278	Eukaryotic homologues of bacterial periplasmic substrate binding proteins; Region: PBPe; smart00079
391165005279	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391165005280	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
391165005281	short chain dehydrogenase; Provisional; Region: PRK06180
391165005282	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
391165005283	NADP binding site [chemical binding]; other site
391165005284	active site
391165005285	steroid binding site; other site
391165005286	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165005287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165005288	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
391165005289	putative effector binding pocket; other site
391165005290	putative dimerization interface [polypeptide binding]; other site
391165005291	Transcriptional regulator; Region: Rrf2; pfam02082
391165005292	Rrf2 family protein; Region: rrf2_super; TIGR00738
391165005293	Methyltransferase domain; Region: Methyltransf_11; pfam08241
391165005294	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
391165005295	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391165005296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391165005297	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
391165005298	NAD(P) binding site [chemical binding]; other site
391165005299	active site lysine
391165005300	Epoxide hydrolase N terminus; Region: EHN; pfam06441
391165005301	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
391165005302	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
391165005303	NIPSNAP; Region: NIPSNAP; pfam07978
391165005304	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
391165005305	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
391165005306	putative NAD(P) binding site [chemical binding]; other site
391165005307	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165005308	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391165005309	sequence-specific DNA binding site [nucleotide binding]; other site
391165005310	salt bridge; other site
391165005311	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391165005312	MULE transposase domain; Region: MULE; pfam10551
391165005313	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391165005314	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391165005315	hypothetical protein; Provisional; Region: PRK06184
391165005316	hypothetical protein; Provisional; Region: PRK07236
391165005317	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
391165005318	Transcriptional regulators [Transcription]; Region: MarR; COG1846
391165005319	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391165005320	putative DNA binding site [nucleotide binding]; other site
391165005321	putative Zn2+ binding site [ion binding]; other site
391165005322	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
391165005323	putative transposase OrfB; Reviewed; Region: PHA02517
391165005324	HTH-like domain; Region: HTH_21; pfam13276
391165005325	Integrase core domain; Region: rve; pfam00665
391165005326	Integrase core domain; Region: rve_3; cl15866
391165005327	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
391165005328	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
391165005329	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391165005330	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
391165005331	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165005332	S-adenosylmethionine binding site [chemical binding]; other site
391165005333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165005334	NmrA-like family; Region: NmrA; pfam05368
391165005335	NAD(P) binding site [chemical binding]; other site
391165005336	active site
391165005337	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
391165005338	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
391165005339	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391165005340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391165005341	Transposase; Region: HTH_Tnp_1; cl17663
391165005342	Integrase core domain; Region: rve; pfam00665
391165005343	Integrase core domain; Region: rve_3; pfam13683
391165005344	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
391165005345	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
391165005346	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
391165005347	putative transposase OrfB; Reviewed; Region: PHA02517
391165005348	HTH-like domain; Region: HTH_21; pfam13276
391165005349	Integrase core domain; Region: rve; pfam00665
391165005350	Integrase core domain; Region: rve_3; pfam13683
391165005351	Transposase; Region: HTH_Tnp_1; pfam01527
391165005352	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
391165005353	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
391165005354	active site
391165005355	Int/Topo IB signature motif; other site
391165005356	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
391165005357	Clp amino terminal domain; Region: Clp_N; pfam02861
391165005358	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165005359	Walker A motif; other site
391165005360	ATP binding site [chemical binding]; other site
391165005361	Walker B motif; other site
391165005362	arginine finger; other site
391165005363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165005364	Walker A motif; other site
391165005365	ATP binding site [chemical binding]; other site
391165005366	Walker B motif; other site
391165005367	arginine finger; other site
391165005368	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
391165005369	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
391165005370	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
391165005371	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
391165005372	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
391165005373	active site
391165005374	DNA binding site [nucleotide binding]
391165005375	fumarate hydratase; Provisional; Region: PRK15389
391165005376	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
391165005377	Fumarase C-terminus; Region: Fumerase_C; pfam05683
391165005378	Stringent starvation protein B; Region: SspB; pfam04386
391165005379	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
391165005380	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
391165005381	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
391165005382	substrate binding site [chemical binding]; other site
391165005383	dimer interface [polypeptide binding]; other site
391165005384	ATP binding site [chemical binding]; other site
391165005385	N-formylglutamate amidohydrolase; Region: FGase; cl01522
391165005386	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
391165005387	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
391165005388	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
391165005389	substrate binding site [chemical binding]; other site
391165005390	oxyanion hole (OAH) forming residues; other site
391165005391	trimer interface [polypeptide binding]; other site
391165005392	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
391165005393	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
391165005394	Cation efflux family; Region: Cation_efflux; pfam01545
391165005395	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
391165005396	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391165005397	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391165005398	catalytic residue [active]
391165005399	Sporulation related domain; Region: SPOR; pfam05036
391165005400	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
391165005401	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
391165005402	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
391165005403	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
391165005404	Walker A/P-loop; other site
391165005405	ATP binding site [chemical binding]; other site
391165005406	Q-loop/lid; other site
391165005407	ABC transporter signature motif; other site
391165005408	Walker B; other site
391165005409	D-loop; other site
391165005410	H-loop/switch region; other site
391165005411	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
391165005412	active site
391165005413	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
391165005414	Amino acid permease; Region: AA_permease_2; pfam13520
391165005415	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391165005416	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391165005417	DNA binding residues [nucleotide binding]
391165005418	dimerization interface [polypeptide binding]; other site
391165005419	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
391165005420	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
391165005421	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
391165005422	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
391165005423	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
391165005424	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391165005425	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
391165005426	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
391165005427	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
391165005428	beta-alpha-beta structure motif; other site
391165005429	NAD binding pocket [chemical binding]; other site
391165005430	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391165005431	catalytic loop [active]
391165005432	iron binding site [ion binding]; other site
391165005433	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
391165005434	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
391165005435	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
391165005436	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
391165005437	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
391165005438	Walker A/P-loop; other site
391165005439	ATP binding site [chemical binding]; other site
391165005440	Q-loop/lid; other site
391165005441	ABC transporter signature motif; other site
391165005442	Walker B; other site
391165005443	D-loop; other site
391165005444	H-loop/switch region; other site
391165005445	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
391165005446	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
391165005447	Walker A/P-loop; other site
391165005448	ATP binding site [chemical binding]; other site
391165005449	Q-loop/lid; other site
391165005450	ABC transporter signature motif; other site
391165005451	Walker B; other site
391165005452	D-loop; other site
391165005453	H-loop/switch region; other site
391165005454	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
391165005455	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
391165005456	TM-ABC transporter signature motif; other site
391165005457	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
391165005458	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
391165005459	TM-ABC transporter signature motif; other site
391165005460	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
391165005461	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
391165005462	putative ligand binding site [chemical binding]; other site
391165005463	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
391165005464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391165005465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165005466	dimer interface [polypeptide binding]; other site
391165005467	phosphorylation site [posttranslational modification]
391165005468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165005469	ATP binding site [chemical binding]; other site
391165005470	Mg2+ binding site [ion binding]; other site
391165005471	G-X-G motif; other site
391165005472	Response regulator receiver domain; Region: Response_reg; pfam00072
391165005473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165005474	active site
391165005475	phosphorylation site [posttranslational modification]
391165005476	intermolecular recognition site; other site
391165005477	Response regulator receiver domain; Region: Response_reg; pfam00072
391165005478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165005479	active site
391165005480	phosphorylation site [posttranslational modification]
391165005481	intermolecular recognition site; other site
391165005482	dimerization interface [polypeptide binding]; other site
391165005483	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391165005484	DNA binding residues [nucleotide binding]
391165005485	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
391165005486	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
391165005487	multimer interface [polypeptide binding]; other site
391165005488	active site
391165005489	catalytic triad [active]
391165005490	dimer interface [polypeptide binding]; other site
391165005491	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165005492	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165005493	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
391165005494	putative effector binding pocket; other site
391165005495	dimerization interface [polypeptide binding]; other site
391165005496	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
391165005497	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
391165005498	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
391165005499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391165005500	EcsC protein family; Region: EcsC; pfam12787
391165005501	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
391165005502	putative mechanosensitive channel protein; Provisional; Region: PRK11465
391165005503	Mechanosensitive ion channel; Region: MS_channel; pfam00924
391165005504	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
391165005505	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
391165005506	Active Sites [active]
391165005507	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615
391165005508	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
391165005509	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165005510	binding surface
391165005511	TPR motif; other site
391165005512	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
391165005513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165005514	TPR motif; other site
391165005515	binding surface
391165005516	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165005517	binding surface
391165005518	TPR motif; other site
391165005519	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
391165005520	Fe-S cluster binding site [ion binding]; other site
391165005521	active site
391165005522	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
391165005523	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391165005524	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391165005525	catalytic residue [active]
391165005526	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
391165005527	MPT binding site; other site
391165005528	trimer interface [polypeptide binding]; other site
391165005529	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
391165005530	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
391165005531	conserved cys residue [active]
391165005532	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
391165005533	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
391165005534	putative ion selectivity filter; other site
391165005535	putative pore gating glutamate residue; other site
391165005536	putative H+/Cl- coupling transport residue; other site
391165005537	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
391165005538	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165005539	FeS/SAM binding site; other site
391165005540	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
391165005541	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
391165005542	RNA/DNA hybrid binding site [nucleotide binding]; other site
391165005543	active site
391165005544	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391165005545	DNA methylase; Region: N6_N4_Mtase; pfam01555
391165005546	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
391165005547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165005548	putative substrate translocation pore; other site
391165005549	POT family; Region: PTR2; cl17359
391165005550	Protein of unknown function (DUF721); Region: DUF721; cl02324
391165005551	Thioredoxin; Region: Thioredoxin_4; pfam13462
391165005552	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
391165005553	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
391165005554	AAA domain; Region: AAA_23; pfam13476
391165005555	Walker A/P-loop; other site
391165005556	ATP binding site [chemical binding]; other site
391165005557	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
391165005558	ABC transporter signature motif; other site
391165005559	Walker B; other site
391165005560	D-loop; other site
391165005561	H-loop/switch region; other site
391165005562	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
391165005563	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
391165005564	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
391165005565	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
391165005566	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
391165005567	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
391165005568	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
391165005569	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
391165005570	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
391165005571	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
391165005572	metal ion-dependent adhesion site (MIDAS); other site
391165005573	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
391165005574	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
391165005575	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
391165005576	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
391165005577	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
391165005578	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
391165005579	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
391165005580	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
391165005581	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
391165005582	putative active site [active]
391165005583	putative substrate binding site [chemical binding]; other site
391165005584	ATP binding site [chemical binding]; other site
391165005585	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
391165005586	RNA/DNA hybrid binding site [nucleotide binding]; other site
391165005587	active site
391165005588	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
391165005589	catalytic triad [active]
391165005590	dimer interface [polypeptide binding]; other site
391165005591	hypothetical protein; Validated; Region: PRK00228
391165005592	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
391165005593	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165005594	motif I; other site
391165005595	active site
391165005596	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165005597	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
391165005598	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
391165005599	quinone interaction residues [chemical binding]; other site
391165005600	active site
391165005601	catalytic residues [active]
391165005602	FMN binding site [chemical binding]; other site
391165005603	substrate binding site [chemical binding]; other site
391165005604	Predicted transcriptional regulator [Transcription]; Region: COG2932
391165005605	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
391165005606	Catalytic site [active]
391165005607	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
391165005608	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
391165005609	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
391165005610	putative dimer interface [polypeptide binding]; other site
391165005611	N-terminal domain interface [polypeptide binding]; other site
391165005612	putative substrate binding pocket (H-site) [chemical binding]; other site
391165005613	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
391165005614	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
391165005615	nudix motif; other site
391165005616	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
391165005617	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
391165005618	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
391165005619	Sodium Bile acid symporter family; Region: SBF; cl17470
391165005620	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
391165005621	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
391165005622	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
391165005623	ethanolamine permease; Region: 2A0305; TIGR00908
391165005624	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
391165005625	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
391165005626	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
391165005627	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
391165005628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165005629	dimer interface [polypeptide binding]; other site
391165005630	conserved gate region; other site
391165005631	putative PBP binding loops; other site
391165005632	ABC-ATPase subunit interface; other site
391165005633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165005634	dimer interface [polypeptide binding]; other site
391165005635	conserved gate region; other site
391165005636	putative PBP binding loops; other site
391165005637	ABC-ATPase subunit interface; other site
391165005638	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
391165005639	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
391165005640	Walker A/P-loop; other site
391165005641	ATP binding site [chemical binding]; other site
391165005642	Q-loop/lid; other site
391165005643	ABC transporter signature motif; other site
391165005644	Walker B; other site
391165005645	D-loop; other site
391165005646	H-loop/switch region; other site
391165005647	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165005648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165005649	active site
391165005650	phosphorylation site [posttranslational modification]
391165005651	intermolecular recognition site; other site
391165005652	dimerization interface [polypeptide binding]; other site
391165005653	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165005654	DNA binding site [nucleotide binding]
391165005655	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391165005656	dimerization interface [polypeptide binding]; other site
391165005657	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165005658	dimer interface [polypeptide binding]; other site
391165005659	phosphorylation site [posttranslational modification]
391165005660	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165005661	ATP binding site [chemical binding]; other site
391165005662	Mg2+ binding site [ion binding]; other site
391165005663	G-X-G motif; other site
391165005664	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
391165005665	active site clefts [active]
391165005666	zinc binding site [ion binding]; other site
391165005667	dimer interface [polypeptide binding]; other site
391165005668	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
391165005669	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
391165005670	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391165005671	protein binding site [polypeptide binding]; other site
391165005672	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391165005673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165005674	active site
391165005675	phosphorylation site [posttranslational modification]
391165005676	intermolecular recognition site; other site
391165005677	dimerization interface [polypeptide binding]; other site
391165005678	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391165005679	DNA binding residues [nucleotide binding]
391165005680	dimerization interface [polypeptide binding]; other site
391165005681	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391165005682	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
391165005683	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
391165005684	Cytochrome c2 [Energy production and conversion]; Region: COG3474
391165005685	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
391165005686	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165005687	Walker A/P-loop; other site
391165005688	ATP binding site [chemical binding]; other site
391165005689	Q-loop/lid; other site
391165005690	ABC transporter signature motif; other site
391165005691	Walker B; other site
391165005692	D-loop; other site
391165005693	H-loop/switch region; other site
391165005694	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
391165005695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165005696	dimer interface [polypeptide binding]; other site
391165005697	conserved gate region; other site
391165005698	putative PBP binding loops; other site
391165005699	ABC-ATPase subunit interface; other site
391165005700	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391165005701	substrate binding pocket [chemical binding]; other site
391165005702	membrane-bound complex binding site; other site
391165005703	hinge residues; other site
391165005704	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
391165005705	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
391165005706	ligand binding site [chemical binding]; other site
391165005707	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
391165005708	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165005709	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165005710	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
391165005711	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
391165005712	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165005713	Walker A/P-loop; other site
391165005714	ATP binding site [chemical binding]; other site
391165005715	Q-loop/lid; other site
391165005716	ABC transporter signature motif; other site
391165005717	Walker B; other site
391165005718	D-loop; other site
391165005719	H-loop/switch region; other site
391165005720	ABC-2 type transporter; Region: ABC2_membrane; cl17235
391165005721	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
391165005722	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
391165005723	active site residue [active]
391165005724	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
391165005725	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391165005726	substrate binding pocket [chemical binding]; other site
391165005727	membrane-bound complex binding site; other site
391165005728	hinge residues; other site
391165005729	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
391165005730	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
391165005731	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
391165005732	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
391165005733	Trp docking motif [polypeptide binding]; other site
391165005734	dimer interface [polypeptide binding]; other site
391165005735	active site
391165005736	small subunit binding site [polypeptide binding]; other site
391165005737	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
391165005738	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165005739	FeS/SAM binding site; other site
391165005740	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
391165005741	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
391165005742	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
391165005743	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
391165005744	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
391165005745	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165005746	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165005747	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
391165005748	dimerization interface [polypeptide binding]; other site
391165005749	Methyltransferase domain; Region: Methyltransf_24; pfam13578
391165005750	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
391165005751	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
391165005752	putative dimer interface [polypeptide binding]; other site
391165005753	[2Fe-2S] cluster binding site [ion binding]; other site
391165005754	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
391165005755	putative dimer interface [polypeptide binding]; other site
391165005756	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
391165005757	SLBB domain; Region: SLBB; pfam10531
391165005758	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
391165005759	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
391165005760	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391165005761	catalytic loop [active]
391165005762	iron binding site [ion binding]; other site
391165005763	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
391165005764	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
391165005765	[4Fe-4S] binding site [ion binding]; other site
391165005766	molybdopterin cofactor binding site; other site
391165005767	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
391165005768	molybdopterin cofactor binding site; other site
391165005769	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
391165005770	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
391165005771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165005772	putative substrate translocation pore; other site
391165005773	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
391165005774	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
391165005775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165005776	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
391165005777	putative dimerization interface [polypeptide binding]; other site
391165005778	putative substrate binding pocket [chemical binding]; other site
391165005779	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
391165005780	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
391165005781	N-terminal plug; other site
391165005782	ligand-binding site [chemical binding]; other site
391165005783	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
391165005784	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
391165005785	catalytic loop [active]
391165005786	iron binding site [ion binding]; other site
391165005787	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391165005788	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
391165005789	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391165005790	catalytic residue [active]
391165005791	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391165005792	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
391165005793	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391165005794	catalytic residue [active]
391165005795	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
391165005796	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
391165005797	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
391165005798	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
391165005799	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
391165005800	active site
391165005801	HIGH motif; other site
391165005802	dimer interface [polypeptide binding]; other site
391165005803	KMSKS motif; other site
391165005804	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391165005805	RNA binding surface [nucleotide binding]; other site
391165005806	ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854
391165005807	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
391165005808	inhibitor-cofactor binding pocket; inhibition site
391165005809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165005810	catalytic residue [active]
391165005811	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
391165005812	Protein of unknown function; Region: DUF3971; pfam13116
391165005813	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
391165005814	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391165005815	metal binding triad; other site
391165005816	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
391165005817	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391165005818	metal binding triad; other site
391165005819	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
391165005820	amino acid transporter; Region: 2A0306; TIGR00909
391165005821	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
391165005822	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
391165005823	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
391165005824	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
391165005825	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
391165005826	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
391165005827	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391165005828	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
391165005829	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
391165005830	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
391165005831	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
391165005832	carboxyltransferase (CT) interaction site; other site
391165005833	biotinylation site [posttranslational modification]; other site
391165005834	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
391165005835	Dehydroquinase class II; Region: DHquinase_II; pfam01220
391165005836	trimer interface [polypeptide binding]; other site
391165005837	active site
391165005838	dimer interface [polypeptide binding]; other site
391165005839	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
391165005840	ThiS interaction site; other site
391165005841	putative active site [active]
391165005842	tetramer interface [polypeptide binding]; other site
391165005843	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
391165005844	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
391165005845	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
391165005846	Zinc-finger domain; Region: zf-CHCC; pfam10276
391165005847	DNA polymerase I; Provisional; Region: PRK05755
391165005848	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
391165005849	active site
391165005850	metal binding site 1 [ion binding]; metal-binding site
391165005851	putative 5' ssDNA interaction site; other site
391165005852	metal binding site 3; metal-binding site
391165005853	metal binding site 2 [ion binding]; metal-binding site
391165005854	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
391165005855	putative DNA binding site [nucleotide binding]; other site
391165005856	putative metal binding site [ion binding]; other site
391165005857	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
391165005858	active site
391165005859	catalytic site [active]
391165005860	substrate binding site [chemical binding]; other site
391165005861	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
391165005862	active site
391165005863	DNA binding site [nucleotide binding]
391165005864	catalytic site [active]
391165005865	Pirin-related protein [General function prediction only]; Region: COG1741
391165005866	Pirin; Region: Pirin; pfam02678
391165005867	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
391165005868	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
391165005869	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165005870	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
391165005871	dimerization interface [polypeptide binding]; other site
391165005872	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
391165005873	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
391165005874	tetramer interface [polypeptide binding]; other site
391165005875	heme binding pocket [chemical binding]; other site
391165005876	NADPH binding site [chemical binding]; other site
391165005877	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
391165005878	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
391165005879	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
391165005880	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165005881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165005882	active site
391165005883	phosphorylation site [posttranslational modification]
391165005884	intermolecular recognition site; other site
391165005885	dimerization interface [polypeptide binding]; other site
391165005886	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165005887	DNA binding site [nucleotide binding]
391165005888	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
391165005889	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
391165005890	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391165005891	HAMP domain; Region: HAMP; pfam00672
391165005892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165005893	dimer interface [polypeptide binding]; other site
391165005894	phosphorylation site [posttranslational modification]
391165005895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165005896	ATP binding site [chemical binding]; other site
391165005897	Mg2+ binding site [ion binding]; other site
391165005898	G-X-G motif; other site
391165005899	OpgC protein; Region: OpgC_C; pfam10129
391165005900	Acyltransferase family; Region: Acyl_transf_3; pfam01757
391165005901	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
391165005902	Protein export membrane protein; Region: SecD_SecF; cl14618
391165005903	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
391165005904	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
391165005905	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
391165005906	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
391165005907	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
391165005908	putative NADP binding site [chemical binding]; other site
391165005909	putative substrate binding site [chemical binding]; other site
391165005910	active site
391165005911	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
391165005912	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
391165005913	active site
391165005914	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
391165005915	active site lid residues [active]
391165005916	substrate binding pocket [chemical binding]; other site
391165005917	catalytic residues [active]
391165005918	substrate-Mg2+ binding site; other site
391165005919	aspartate-rich region 1; other site
391165005920	aspartate-rich region 2; other site
391165005921	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
391165005922	active site lid residues [active]
391165005923	substrate binding pocket [chemical binding]; other site
391165005924	catalytic residues [active]
391165005925	substrate-Mg2+ binding site; other site
391165005926	aspartate-rich region 1; other site
391165005927	aspartate-rich region 2; other site
391165005928	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
391165005929	active site
391165005930	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
391165005931	dimer interface [polypeptide binding]; other site
391165005932	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
391165005933	Ligand Binding Site [chemical binding]; other site
391165005934	Molecular Tunnel; other site
391165005935	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
391165005936	putative ADP-binding pocket [chemical binding]; other site
391165005937	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165005938	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
391165005939	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
391165005940	putative active site [active]
391165005941	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
391165005942	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
391165005943	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
391165005944	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
391165005945	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391165005946	Walker A/P-loop; other site
391165005947	ATP binding site [chemical binding]; other site
391165005948	Q-loop/lid; other site
391165005949	ABC transporter signature motif; other site
391165005950	Walker B; other site
391165005951	D-loop; other site
391165005952	H-loop/switch region; other site
391165005953	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391165005954	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391165005955	Walker A/P-loop; other site
391165005956	ATP binding site [chemical binding]; other site
391165005957	Q-loop/lid; other site
391165005958	ABC transporter signature motif; other site
391165005959	Walker B; other site
391165005960	D-loop; other site
391165005961	H-loop/switch region; other site
391165005962	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391165005963	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
391165005964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165005965	dimer interface [polypeptide binding]; other site
391165005966	conserved gate region; other site
391165005967	putative PBP binding loops; other site
391165005968	ABC-ATPase subunit interface; other site
391165005969	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
391165005970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165005971	dimer interface [polypeptide binding]; other site
391165005972	conserved gate region; other site
391165005973	ABC-ATPase subunit interface; other site
391165005974	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
391165005975	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
391165005976	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
391165005977	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
391165005978	active site
391165005979	Cytochrome c; Region: Cytochrom_C; cl11414
391165005980	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
391165005981	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
391165005982	Ligand binding site; other site
391165005983	oligomer interface; other site
391165005984	prephenate dehydratase; Provisional; Region: PRK11899
391165005985	Prephenate dehydratase; Region: PDT; pfam00800
391165005986	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
391165005987	putative L-Phe binding site [chemical binding]; other site
391165005988	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
391165005989	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
391165005990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
391165005991	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
391165005992	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
391165005993	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391165005994	non-specific DNA binding site [nucleotide binding]; other site
391165005995	salt bridge; other site
391165005996	sequence-specific DNA binding site [nucleotide binding]; other site
391165005997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
391165005998	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165005999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165006000	active site
391165006001	phosphorylation site [posttranslational modification]
391165006002	intermolecular recognition site; other site
391165006003	dimerization interface [polypeptide binding]; other site
391165006004	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165006005	DNA binding site [nucleotide binding]
391165006006	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
391165006007	putative catalytic site [active]
391165006008	putative phosphate binding site [ion binding]; other site
391165006009	active site
391165006010	metal binding site A [ion binding]; metal-binding site
391165006011	DNA binding site [nucleotide binding]
391165006012	putative AP binding site [nucleotide binding]; other site
391165006013	putative metal binding site B [ion binding]; other site
391165006014	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
391165006015	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
391165006016	Peptidase C26; Region: Peptidase_C26; pfam07722
391165006017	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
391165006018	catalytic triad [active]
391165006019	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
391165006020	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391165006021	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
391165006022	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
391165006023	Phosphotransferase enzyme family; Region: APH; pfam01636
391165006024	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
391165006025	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
391165006026	Substrate binding site; other site
391165006027	metal-binding site
391165006028	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
391165006029	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
391165006030	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
391165006031	Family description; Region: UvrD_C_2; pfam13538
391165006032	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391165006033	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
391165006034	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
391165006035	catalytic residues [active]
391165006036	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
391165006037	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
391165006038	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
391165006039	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
391165006040	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
391165006041	substrate binding site [chemical binding]; other site
391165006042	active site
391165006043	catalytic residues [active]
391165006044	heterodimer interface [polypeptide binding]; other site
391165006045	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
391165006046	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
391165006047	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165006048	catalytic residue [active]
391165006049	malate dehydrogenase; Provisional; Region: PRK13529
391165006050	Malic enzyme, N-terminal domain; Region: malic; pfam00390
391165006051	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
391165006052	NAD(P) binding site [chemical binding]; other site
391165006053	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
391165006054	active site
391165006055	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
391165006056	active site
391165006057	dimer interface [polypeptide binding]; other site
391165006058	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
391165006059	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
391165006060	IHF dimer interface [polypeptide binding]; other site
391165006061	IHF - DNA interface [nucleotide binding]; other site
391165006062	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
391165006063	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
391165006064	tandem repeat interface [polypeptide binding]; other site
391165006065	oligomer interface [polypeptide binding]; other site
391165006066	active site residues [active]
391165006067	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
391165006068	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
391165006069	RNA binding site [nucleotide binding]; other site
391165006070	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
391165006071	RNA binding site [nucleotide binding]; other site
391165006072	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
391165006073	RNA binding site [nucleotide binding]; other site
391165006074	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391165006075	RNA binding site [nucleotide binding]; other site
391165006076	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391165006077	RNA binding site [nucleotide binding]; other site
391165006078	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
391165006079	RNA binding site [nucleotide binding]; other site
391165006080	cytidylate kinase; Provisional; Region: cmk; PRK00023
391165006081	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
391165006082	CMP-binding site; other site
391165006083	The sites determining sugar specificity; other site
391165006084	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
391165006085	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
391165006086	hinge; other site
391165006087	active site
391165006088	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
391165006089	TIGR02300 family protein; Region: FYDLN_acid
391165006090	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
391165006091	putative hydrophobic ligand binding site [chemical binding]; other site
391165006092	protein interface [polypeptide binding]; other site
391165006093	gate; other site
391165006094	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
391165006095	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
391165006096	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
391165006097	Multicopper oxidase; Region: Cu-oxidase; pfam00394
391165006098	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
391165006099	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391165006100	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391165006101	Bacterial transcriptional repressor; Region: TetR; pfam13972
391165006102	polyphosphate kinase; Provisional; Region: PRK05443
391165006103	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
391165006104	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
391165006105	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
391165006106	putative domain interface [polypeptide binding]; other site
391165006107	putative active site [active]
391165006108	catalytic site [active]
391165006109	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
391165006110	putative domain interface [polypeptide binding]; other site
391165006111	putative active site [active]
391165006112	catalytic site [active]
391165006113	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
391165006114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
391165006115	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
391165006116	Domain of unknown function DUF20; Region: UPF0118; pfam01594
391165006117	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
391165006118	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
391165006119	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
391165006120	dimerization interface [polypeptide binding]; other site
391165006121	putative ATP binding site [chemical binding]; other site
391165006122	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
391165006123	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
391165006124	active site
391165006125	substrate binding site [chemical binding]; other site
391165006126	cosubstrate binding site; other site
391165006127	catalytic site [active]
391165006128	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
391165006129	active site
391165006130	multimer interface [polypeptide binding]; other site
391165006131	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
391165006132	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391165006133	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391165006134	ABC transporter; Region: ABC_tran_2; pfam12848
391165006135	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391165006136	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
391165006137	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
391165006138	putative homodimer interface [polypeptide binding]; other site
391165006139	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
391165006140	heterodimer interface [polypeptide binding]; other site
391165006141	homodimer interface [polypeptide binding]; other site
391165006142	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
391165006143	phosphogluconate dehydratase; Validated; Region: PRK09054
391165006144	6-phosphogluconate dehydratase; Region: edd; TIGR01196
391165006145	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
391165006146	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
391165006147	active site
391165006148	intersubunit interface [polypeptide binding]; other site
391165006149	catalytic residue [active]
391165006150	Protein of unknown function DUF45; Region: DUF45; pfam01863
391165006151	hypothetical protein; Provisional; Region: PRK05170
391165006152	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
391165006153	putative amphipathic alpha helix; other site
391165006154	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
391165006155	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
391165006156	substrate binding site [chemical binding]; other site
391165006157	ATP binding site [chemical binding]; other site
391165006158	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
391165006159	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
391165006160	tartrate dehydrogenase; Region: TTC; TIGR02089
391165006161	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
391165006162	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
391165006163	Na binding site [ion binding]; other site
391165006164	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
391165006165	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
391165006166	dinuclear metal binding motif [ion binding]; other site
391165006167	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
391165006168	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
391165006169	gamma subunit interface [polypeptide binding]; other site
391165006170	epsilon subunit interface [polypeptide binding]; other site
391165006171	LBP interface [polypeptide binding]; other site
391165006172	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
391165006173	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
391165006174	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
391165006175	alpha subunit interaction interface [polypeptide binding]; other site
391165006176	Walker A motif; other site
391165006177	ATP binding site [chemical binding]; other site
391165006178	Walker B motif; other site
391165006179	inhibitor binding site; inhibition site
391165006180	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
391165006181	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
391165006182	core domain interface [polypeptide binding]; other site
391165006183	delta subunit interface [polypeptide binding]; other site
391165006184	epsilon subunit interface [polypeptide binding]; other site
391165006185	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
391165006186	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
391165006187	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
391165006188	beta subunit interaction interface [polypeptide binding]; other site
391165006189	Walker A motif; other site
391165006190	ATP binding site [chemical binding]; other site
391165006191	Walker B motif; other site
391165006192	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
391165006193	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
391165006194	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
391165006195	primosome assembly protein PriA; Validated; Region: PRK05580
391165006196	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391165006197	ATP binding site [chemical binding]; other site
391165006198	putative Mg++ binding site [ion binding]; other site
391165006199	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
391165006200	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391165006201	active site
391165006202	DNA binding site [nucleotide binding]
391165006203	Int/Topo IB signature motif; other site
391165006204	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
391165006205	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
391165006206	active site
391165006207	hydrophilic channel; other site
391165006208	dimerization interface [polypeptide binding]; other site
391165006209	catalytic residues [active]
391165006210	active site lid [active]
391165006211	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
391165006212	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
391165006213	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
391165006214	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391165006215	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391165006216	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391165006217	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
391165006218	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
391165006219	E3 interaction surface; other site
391165006220	lipoyl attachment site [posttranslational modification]; other site
391165006221	e3 binding domain; Region: E3_binding; pfam02817
391165006222	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
391165006223	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
391165006224	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
391165006225	TPP-binding site [chemical binding]; other site
391165006226	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
391165006227	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
391165006228	CoA binding domain; Region: CoA_binding; smart00881
391165006229	CoA-ligase; Region: Ligase_CoA; pfam00549
391165006230	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
391165006231	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
391165006232	CoA-ligase; Region: Ligase_CoA; pfam00549
391165006233	malate dehydrogenase; Reviewed; Region: PRK06223
391165006234	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
391165006235	NAD(P) binding site [chemical binding]; other site
391165006236	dimer interface [polypeptide binding]; other site
391165006237	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391165006238	substrate binding site [chemical binding]; other site
391165006239	Predicted ATPase [General function prediction only]; Region: COG1485
391165006240	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
391165006241	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
391165006242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165006243	putative substrate translocation pore; other site
391165006244	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
391165006245	Putative phosphatase (DUF442); Region: DUF442; cl17385
391165006246	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
391165006247	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
391165006248	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
391165006249	L-aspartate oxidase; Provisional; Region: PRK06175
391165006250	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
391165006251	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
391165006252	putative SdhC subunit interface [polypeptide binding]; other site
391165006253	putative proximal heme binding site [chemical binding]; other site
391165006254	putative Iron-sulfur protein interface [polypeptide binding]; other site
391165006255	putative proximal quinone binding site; other site
391165006256	succinate dehydrogenase, cytochrome b subunit family; Provisional; Region: PLN00126
391165006257	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
391165006258	Iron-sulfur protein interface; other site
391165006259	proximal quinone binding site [chemical binding]; other site
391165006260	SdhD (CybS) interface [polypeptide binding]; other site
391165006261	proximal heme binding site [chemical binding]; other site
391165006262	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
391165006263	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
391165006264	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
391165006265	MarR family; Region: MarR; pfam01047
391165006266	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
391165006267	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
391165006268	Walker A motif; other site
391165006269	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
391165006270	MoaE interaction surface [polypeptide binding]; other site
391165006271	MoeB interaction surface [polypeptide binding]; other site
391165006272	thiocarboxylated glycine; other site
391165006273	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
391165006274	MoaD interaction [polypeptide binding]; other site
391165006275	active site residues [active]
391165006276	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
391165006277	metal-binding site [ion binding]
391165006278	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
391165006279	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
391165006280	metal-binding site [ion binding]
391165006281	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391165006282	Soluble P-type ATPase [General function prediction only]; Region: COG4087
391165006283	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
391165006284	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
391165006285	DNA binding residues [nucleotide binding]
391165006286	dimer interface [polypeptide binding]; other site
391165006287	copper binding site [ion binding]; other site
391165006288	EF-hand domain pair; Region: EF_hand_5; pfam13499
391165006289	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
391165006290	Ca2+ binding site [ion binding]; other site
391165006291	EF-hand domain pair; Region: EF_hand_5; pfam13499
391165006292	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
391165006293	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
391165006294	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
391165006295	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
391165006296	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
391165006297	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
391165006298	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
391165006299	Ligand binding site [chemical binding]; other site
391165006300	Electron transfer flavoprotein domain; Region: ETF; pfam01012
391165006301	Biofilm formation and stress response factor; Region: BsmA; pfam10014
391165006302	pyruvate phosphate dikinase; Provisional; Region: PRK09279
391165006303	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
391165006304	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
391165006305	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
391165006306	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
391165006307	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
391165006308	putative active site [active]
391165006309	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
391165006310	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
391165006311	dimer interface [polypeptide binding]; other site
391165006312	motif 1; other site
391165006313	active site
391165006314	motif 2; other site
391165006315	motif 3; other site
391165006316	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
391165006317	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
391165006318	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165006319	LysR substrate binding domain; Region: LysR_substrate; pfam03466
391165006320	dimerization interface [polypeptide binding]; other site
391165006321	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
391165006322	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
391165006323	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
391165006324	Active site cavity [active]
391165006325	catalytic acid [active]
391165006326	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
391165006327	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
391165006328	putative active site [active]
391165006329	heme pocket [chemical binding]; other site
391165006330	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
391165006331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
391165006332	putative active site [active]
391165006333	heme pocket [chemical binding]; other site
391165006334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
391165006335	putative active site [active]
391165006336	heme pocket [chemical binding]; other site
391165006337	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165006338	dimer interface [polypeptide binding]; other site
391165006339	phosphorylation site [posttranslational modification]
391165006340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165006341	ATP binding site [chemical binding]; other site
391165006342	Mg2+ binding site [ion binding]; other site
391165006343	G-X-G motif; other site
391165006344	Response regulator receiver domain; Region: Response_reg; pfam00072
391165006345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165006346	active site
391165006347	phosphorylation site [posttranslational modification]
391165006348	intermolecular recognition site; other site
391165006349	dimerization interface [polypeptide binding]; other site
391165006350	Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690
391165006351	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
391165006352	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
391165006353	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
391165006354	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
391165006355	active site
391165006356	FMN binding site [chemical binding]; other site
391165006357	substrate binding site [chemical binding]; other site
391165006358	3Fe-4S cluster binding site [ion binding]; other site
391165006359	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
391165006360	domain_subunit interface; other site
391165006361	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
391165006362	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
391165006363	putative active site [active]
391165006364	Bacterial SH3 domain; Region: SH3_4; pfam06347
391165006365	Bacterial SH3 domain; Region: SH3_4; pfam06347
391165006366	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
391165006367	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
391165006368	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
391165006369	ATP binding site [chemical binding]; other site
391165006370	substrate interface [chemical binding]; other site
391165006371	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
391165006372	Ligand Binding Site [chemical binding]; other site
391165006373	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
391165006374	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
391165006375	G1 box; other site
391165006376	putative GEF interaction site [polypeptide binding]; other site
391165006377	GTP/Mg2+ binding site [chemical binding]; other site
391165006378	Switch I region; other site
391165006379	G2 box; other site
391165006380	G3 box; other site
391165006381	Switch II region; other site
391165006382	G4 box; other site
391165006383	G5 box; other site
391165006384	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
391165006385	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
391165006386	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
391165006387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165006388	Walker A/P-loop; other site
391165006389	ATP binding site [chemical binding]; other site
391165006390	Q-loop/lid; other site
391165006391	ABC transporter signature motif; other site
391165006392	Walker B; other site
391165006393	D-loop; other site
391165006394	H-loop/switch region; other site
391165006395	TOBE domain; Region: TOBE; cl01440
391165006396	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
391165006397	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
391165006398	putative transporter; Provisional; Region: PRK10504
391165006399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165006400	putative substrate translocation pore; other site
391165006401	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
391165006402	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
391165006403	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
391165006404	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
391165006405	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
391165006406	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
391165006407	FMN binding site [chemical binding]; other site
391165006408	active site
391165006409	substrate binding site [chemical binding]; other site
391165006410	catalytic residue [active]
391165006411	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
391165006412	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
391165006413	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
391165006414	HlyD family secretion protein; Region: HlyD_3; pfam13437
391165006415	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
391165006416	Fusaric acid resistance protein family; Region: FUSC; pfam04632
391165006417	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
391165006418	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
391165006419	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
391165006420	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
391165006421	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
391165006422	Nitrogen regulatory protein P-II; Region: P-II; smart00938
391165006423	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
391165006424	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
391165006425	phosphoribulokinase; Provisional; Region: PRK15453
391165006426	active site
391165006427	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
391165006428	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165006429	Walker A motif; other site
391165006430	ATP binding site [chemical binding]; other site
391165006431	Walker B motif; other site
391165006432	arginine finger; other site
391165006433	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
391165006434	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
391165006435	substrate binding site [chemical binding]; other site
391165006436	hexamer interface [polypeptide binding]; other site
391165006437	metal binding site [ion binding]; metal-binding site
391165006438	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
391165006439	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
391165006440	active site
391165006441	catalytic site [active]
391165006442	substrate binding site [chemical binding]; other site
391165006443	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
391165006444	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
391165006445	CoA-binding site [chemical binding]; other site
391165006446	ATP-binding [chemical binding]; other site
391165006447	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
391165006448	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
391165006449	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
391165006450	shikimate binding site; other site
391165006451	NAD(P) binding site [chemical binding]; other site
391165006452	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391165006453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165006454	putative substrate translocation pore; other site
391165006455	PRC-barrel domain; Region: PRC; pfam05239
391165006456	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
391165006457	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
391165006458	transmembrane helices; other site
391165006459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165006460	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391165006461	putative substrate translocation pore; other site
391165006462	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
391165006463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165006464	intermolecular recognition site; other site
391165006465	active site
391165006466	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165006467	dimerization interface [polypeptide binding]; other site
391165006468	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165006469	DNA binding site [nucleotide binding]
391165006470	putative glycosyl transferase; Provisional; Region: PRK10018
391165006471	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
391165006472	Probable Catalytic site; other site
391165006473	metal-binding site
391165006474	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391165006475	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
391165006476	Probable Catalytic site; other site
391165006477	metal-binding site
391165006478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165006479	Tetratricopeptide repeat; Region: TPR_16; pfam13432
391165006480	binding surface
391165006481	TPR motif; other site
391165006482	TPR repeat; Region: TPR_11; pfam13414
391165006483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165006484	binding surface
391165006485	TPR motif; other site
391165006486	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391165006487	TPR repeat; Region: TPR_11; pfam13414
391165006488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165006489	binding surface
391165006490	TPR motif; other site
391165006491	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391165006492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391165006493	binding surface
391165006494	TPR motif; other site
391165006495	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
391165006496	intersubunit interface [polypeptide binding]; other site
391165006497	active site
391165006498	Zn2+ binding site [ion binding]; other site
391165006499	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
391165006500	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
391165006501	SelR domain; Region: SelR; pfam01641
391165006502	methionine sulfoxide reductase B; Provisional; Region: PRK00222
391165006503	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
391165006504	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
391165006505	CysD dimerization site [polypeptide binding]; other site
391165006506	G1 box; other site
391165006507	putative GEF interaction site [polypeptide binding]; other site
391165006508	GTP/Mg2+ binding site [chemical binding]; other site
391165006509	Switch I region; other site
391165006510	G2 box; other site
391165006511	G3 box; other site
391165006512	Switch II region; other site
391165006513	G4 box; other site
391165006514	G5 box; other site
391165006515	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
391165006516	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
391165006517	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
391165006518	ligand-binding site [chemical binding]; other site
391165006519	UreD urease accessory protein; Region: UreD; pfam01774
391165006520	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
391165006521	alpha-gamma subunit interface [polypeptide binding]; other site
391165006522	beta-gamma subunit interface [polypeptide binding]; other site
391165006523	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
391165006524	gamma-beta subunit interface [polypeptide binding]; other site
391165006525	alpha-beta subunit interface [polypeptide binding]; other site
391165006526	urease subunit alpha; Reviewed; Region: ureC; PRK13207
391165006527	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
391165006528	subunit interactions [polypeptide binding]; other site
391165006529	active site
391165006530	flap region; other site
391165006531	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
391165006532	dimer interface [polypeptide binding]; other site
391165006533	catalytic residues [active]
391165006534	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
391165006535	UreF; Region: UreF; pfam01730
391165006536	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391165006537	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
391165006538	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
391165006539	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
391165006540	RmuC family; Region: RmuC; pfam02646
391165006541	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
391165006542	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
391165006543	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
391165006544	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
391165006545	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
391165006546	active site
391165006547	catalytic site [active]
391165006548	Predicted integral membrane protein [Function unknown]; Region: COG0392
391165006549	Uncharacterized conserved protein [Function unknown]; Region: COG2898
391165006550	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
391165006551	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
391165006552	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391165006553	active site
391165006554	nucleotide binding site [chemical binding]; other site
391165006555	HIGH motif; other site
391165006556	KMSKS motif; other site
391165006557	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391165006558	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
391165006559	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
391165006560	tellurite resistance protein terB; Region: terB; cd07176
391165006561	putative metal binding site [ion binding]; other site
391165006562	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
391165006563	DNA-binding site [nucleotide binding]; DNA binding site
391165006564	RNA-binding motif; other site
391165006565	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
391165006566	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
391165006567	ring oligomerisation interface [polypeptide binding]; other site
391165006568	ATP/Mg binding site [chemical binding]; other site
391165006569	stacking interactions; other site
391165006570	hinge regions; other site
391165006571	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
391165006572	oligomerisation interface [polypeptide binding]; other site
391165006573	mobile loop; other site
391165006574	roof hairpin; other site
391165006575	Usg-like family; Region: Usg; pfam06233
391165006576	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
391165006577	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
391165006578	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
391165006579	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
391165006580	active site
391165006581	catalytic triad [active]
391165006582	oxyanion hole [active]
391165006583	glutamate--cysteine ligase; Region: PLN02611
391165006584	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
391165006585	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
391165006586	UbiA prenyltransferase family; Region: UbiA; pfam01040
391165006587	Predicted methyltransferase [General function prediction only]; Region: COG3897
391165006588	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391165006589	Ligand Binding Site [chemical binding]; other site
391165006590	Protein of unknown function (DUF952); Region: DUF952; pfam06108
391165006591	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
391165006592	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
391165006593	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
391165006594	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
391165006595	active site
391165006596	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
391165006597	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
391165006598	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165006599	S-adenosylmethionine binding site [chemical binding]; other site
391165006600	SurA N-terminal domain; Region: SurA_N; pfam09312
391165006601	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
391165006602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
391165006603	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
391165006604	OstA-like protein; Region: OstA; cl00844
391165006605	Organic solvent tolerance protein; Region: OstA_C; pfam04453
391165006606	Predicted permeases [General function prediction only]; Region: COG0795
391165006607	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
391165006608	Predicted permeases [General function prediction only]; Region: COG0795
391165006609	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
391165006610	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
391165006611	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
391165006612	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
391165006613	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
391165006614	active site
391165006615	multifunctional aminopeptidase A; Provisional; Region: PRK00913
391165006616	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
391165006617	interface (dimer of trimers) [polypeptide binding]; other site
391165006618	Substrate-binding/catalytic site; other site
391165006619	Zn-binding sites [ion binding]; other site
391165006620	DNA polymerase III subunit chi; Validated; Region: PRK05728
391165006621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391165006622	Coenzyme A binding pocket [chemical binding]; other site
391165006623	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
391165006624	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
391165006625	catalytic site [active]
391165006626	G-X2-G-X-G-K; other site
391165006627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165006628	NAD(P) binding site [chemical binding]; other site
391165006629	active site
391165006630	YceG-like family; Region: YceG; pfam02618
391165006631	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
391165006632	dimerization interface [polypeptide binding]; other site
391165006633	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
391165006634	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
391165006635	dimer interface [polypeptide binding]; other site
391165006636	active site
391165006637	acyl carrier protein; Provisional; Region: acpP; PRK00982
391165006638	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
391165006639	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165006640	NAD(P) binding site [chemical binding]; other site
391165006641	active site
391165006642	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
391165006643	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
391165006644	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
391165006645	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
391165006646	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
391165006647	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
391165006648	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
391165006649	replicative DNA helicase; Provisional; Region: PRK09165
391165006650	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
391165006651	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
391165006652	Walker A motif; other site
391165006653	ATP binding site [chemical binding]; other site
391165006654	Walker B motif; other site
391165006655	DNA binding loops [nucleotide binding]
391165006656	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
391165006657	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
391165006658	active site
391165006659	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391165006660	dimer interface [polypeptide binding]; other site
391165006661	substrate binding site [chemical binding]; other site
391165006662	catalytic residues [active]
391165006663	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
391165006664	Permease; Region: Permease; pfam02405
391165006665	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
391165006666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391165006667	Walker A/P-loop; other site
391165006668	ATP binding site [chemical binding]; other site
391165006669	Q-loop/lid; other site
391165006670	ABC transporter signature motif; other site
391165006671	Walker B; other site
391165006672	D-loop; other site
391165006673	H-loop/switch region; other site
391165006674	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
391165006675	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
391165006676	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
391165006677	Methyltransferase domain; Region: Methyltransf_23; pfam13489
391165006678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165006679	S-adenosylmethionine binding site [chemical binding]; other site
391165006680	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
391165006681	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391165006682	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
391165006683	active site
391165006684	excinuclease ABC subunit B; Provisional; Region: PRK05298
391165006685	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391165006686	ATP binding site [chemical binding]; other site
391165006687	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165006688	nucleotide binding region [chemical binding]; other site
391165006689	ATP-binding site [chemical binding]; other site
391165006690	Ultra-violet resistance protein B; Region: UvrB; pfam12344
391165006691	UvrB/uvrC motif; Region: UVR; pfam02151
391165006692	short chain dehydrogenase; Provisional; Region: PRK09134
391165006693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165006694	NAD(P) binding site [chemical binding]; other site
391165006695	active site
391165006696	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
391165006697	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
391165006698	GIY-YIG motif/motif A; other site
391165006699	active site
391165006700	catalytic site [active]
391165006701	putative DNA binding site [nucleotide binding]; other site
391165006702	metal binding site [ion binding]; metal-binding site
391165006703	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
391165006704	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
391165006705	nucleotide binding site/active site [active]
391165006706	HIT family signature motif; other site
391165006707	catalytic residue [active]
391165006708	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
391165006709	metal binding site [ion binding]; metal-binding site
391165006710	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
391165006711	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
391165006712	substrate binding site [chemical binding]; other site
391165006713	glutamase interaction surface [polypeptide binding]; other site
391165006714	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
391165006715	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
391165006716	catalytic residues [active]
391165006717	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
391165006718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391165006719	Coenzyme A binding pocket [chemical binding]; other site
391165006720	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
391165006721	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
391165006722	putative active site [active]
391165006723	oxyanion strand; other site
391165006724	catalytic triad [active]
391165006725	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
391165006726	putative active site pocket [active]
391165006727	4-fold oligomerization interface [polypeptide binding]; other site
391165006728	metal binding residues [ion binding]; metal-binding site
391165006729	3-fold/trimer interface [polypeptide binding]; other site
391165006730	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
391165006731	active site
391165006732	HslU subunit interaction site [polypeptide binding]; other site
391165006733	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
391165006734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391165006735	Walker A motif; other site
391165006736	ATP binding site [chemical binding]; other site
391165006737	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
391165006738	Walker B motif; other site
391165006739	arginine finger; other site
391165006740	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
391165006741	Fe-S metabolism associated domain; Region: SufE; cl00951
391165006742	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
391165006743	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165006744	active site
391165006745	motif I; other site
391165006746	motif II; other site
391165006747	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391165006748	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
391165006749	MarR family; Region: MarR_2; pfam12802
391165006750	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391165006751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165006752	active site
391165006753	phosphorylation site [posttranslational modification]
391165006754	intermolecular recognition site; other site
391165006755	dimerization interface [polypeptide binding]; other site
391165006756	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391165006757	DNA binding site [nucleotide binding]
391165006758	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391165006759	dimerization interface [polypeptide binding]; other site
391165006760	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165006761	dimer interface [polypeptide binding]; other site
391165006762	phosphorylation site [posttranslational modification]
391165006763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165006764	ATP binding site [chemical binding]; other site
391165006765	Mg2+ binding site [ion binding]; other site
391165006766	G-X-G motif; other site
391165006767	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
391165006768	putative acyl-acceptor binding pocket; other site
391165006769	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
391165006770	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
391165006771	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
391165006772	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
391165006773	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
391165006774	putative acyl-acceptor binding pocket; other site
391165006775	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391165006776	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
391165006777	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
391165006778	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
391165006779	putative active site [active]
391165006780	putative metal binding site [ion binding]; other site
391165006781	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
391165006782	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
391165006783	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
391165006784	Subunit III/VIIa interface [polypeptide binding]; other site
391165006785	Phospholipid binding site [chemical binding]; other site
391165006786	Subunit I/III interface [polypeptide binding]; other site
391165006787	Subunit III/VIb interface [polypeptide binding]; other site
391165006788	Subunit III/VIa interface; other site
391165006789	Subunit III/Vb interface [polypeptide binding]; other site
391165006790	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
391165006791	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
391165006792	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
391165006793	active site
391165006794	Zn binding site [ion binding]; other site
391165006795	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
391165006796	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
391165006797	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165006798	catalytic residue [active]
391165006799	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
391165006800	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
391165006801	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
391165006802	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
391165006803	Tim44-like domain; Region: Tim44; pfam04280
391165006804	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
391165006805	UbiA prenyltransferase family; Region: UbiA; pfam01040
391165006806	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
391165006807	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
391165006808	Subunit I/III interface [polypeptide binding]; other site
391165006809	D-pathway; other site
391165006810	Subunit I/VIIc interface [polypeptide binding]; other site
391165006811	Subunit I/IV interface [polypeptide binding]; other site
391165006812	Subunit I/II interface [polypeptide binding]; other site
391165006813	Low-spin heme (heme a) binding site [chemical binding]; other site
391165006814	Subunit I/VIIa interface [polypeptide binding]; other site
391165006815	Subunit I/VIa interface [polypeptide binding]; other site
391165006816	Dimer interface; other site
391165006817	Putative water exit pathway; other site
391165006818	Binuclear center (heme a3/CuB) [ion binding]; other site
391165006819	K-pathway; other site
391165006820	Subunit I/Vb interface [polypeptide binding]; other site
391165006821	Putative proton exit pathway; other site
391165006822	Subunit I/VIb interface; other site
391165006823	Subunit I/VIc interface [polypeptide binding]; other site
391165006824	Electron transfer pathway; other site
391165006825	Subunit I/VIIIb interface [polypeptide binding]; other site
391165006826	Subunit I/VIIb interface [polypeptide binding]; other site
391165006827	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
391165006828	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00139
391165006829	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
391165006830	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391165006831	S-adenosylmethionine binding site [chemical binding]; other site
391165006832	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
391165006833	DNA-binding site [nucleotide binding]; DNA binding site
391165006834	RNA-binding motif; other site
391165006835	GcrA cell cycle regulator; Region: GcrA; cl11564
391165006836	GcrA cell cycle regulator; Region: GcrA; cl11564
391165006837	CHAP domain; Region: CHAP; cl17642
391165006838	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
391165006839	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
391165006840	intersubunit interface [polypeptide binding]; other site
391165006841	active site
391165006842	Zn2+ binding site [ion binding]; other site
391165006843	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
391165006844	Cupin domain; Region: Cupin_2; cl17218
391165006845	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
391165006846	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
391165006847	motif II; other site
391165006848	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
391165006849	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
391165006850	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
391165006851	dimerization interface [polypeptide binding]; other site
391165006852	domain crossover interface; other site
391165006853	redox-dependent activation switch; other site
391165006854	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
391165006855	putative homodimer interface [polypeptide binding]; other site
391165006856	putative homotetramer interface [polypeptide binding]; other site
391165006857	putative metal binding site [ion binding]; other site
391165006858	putative homodimer-homodimer interface [polypeptide binding]; other site
391165006859	putative allosteric switch controlling residues; other site
391165006860	serine acetyltransferase; Provisional; Region: cysE; PRK11132
391165006861	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
391165006862	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
391165006863	trimer interface [polypeptide binding]; other site
391165006864	active site
391165006865	substrate binding site [chemical binding]; other site
391165006866	CoA binding site [chemical binding]; other site
391165006867	ornithine carbamoyltransferase; Provisional; Region: PRK00779
391165006868	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
391165006869	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
391165006870	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
391165006871	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
391165006872	inhibitor-cofactor binding pocket; inhibition site
391165006873	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165006874	catalytic residue [active]
391165006875	RecX family; Region: RecX; pfam02631
391165006876	Predicted membrane protein [Function unknown]; Region: COG2246
391165006877	GtrA-like protein; Region: GtrA; pfam04138
391165006878	hypothetical protein; Provisional; Region: PRK07233
391165006879	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391165006880	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391165006881	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
391165006882	NAD(P) binding site [chemical binding]; other site
391165006883	active site
391165006884	short chain dehydrogenase; Provisional; Region: PRK08251
391165006885	classical (c) SDRs; Region: SDR_c; cd05233
391165006886	NAD(P) binding site [chemical binding]; other site
391165006887	active site
391165006888	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
391165006889	FAD binding domain; Region: FAD_binding_4; pfam01565
391165006890	hypothetical protein; Validated; Region: PRK08238
391165006891	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
391165006892	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
391165006893	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
391165006894	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391165006895	Coenzyme A binding pocket [chemical binding]; other site
391165006896	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
391165006897	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
391165006898	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
391165006899	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
391165006900	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391165006901	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
391165006902	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391165006903	DNA binding residues [nucleotide binding]
391165006904	DNA primase, catalytic core; Region: dnaG; TIGR01391
391165006905	CHC2 zinc finger; Region: zf-CHC2; pfam01807
391165006906	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
391165006907	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
391165006908	active site
391165006909	metal binding site [ion binding]; metal-binding site
391165006910	interdomain interaction site; other site
391165006911	Yqey-like protein; Region: YqeY; cl17540
391165006912	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
391165006913	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
391165006914	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
391165006915	catalytic site [active]
391165006916	subunit interface [polypeptide binding]; other site
391165006917	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
391165006918	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391165006919	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
391165006920	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
391165006921	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391165006922	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391165006923	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
391165006924	IMP binding site; other site
391165006925	dimer interface [polypeptide binding]; other site
391165006926	partial ornithine binding site; other site
391165006927	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
391165006928	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
391165006929	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
391165006930	threonine dehydratase; Provisional; Region: PRK07334
391165006931	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
391165006932	tetramer interface [polypeptide binding]; other site
391165006933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391165006934	catalytic residue [active]
391165006935	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
391165006936	dihydroorotase; Validated; Region: PRK09060
391165006937	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
391165006938	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
391165006939	active site
391165006940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165006941	metabolite-proton symporter; Region: 2A0106; TIGR00883
391165006942	putative substrate translocation pore; other site
391165006943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
391165006944	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
391165006945	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
391165006946	Trp docking motif [polypeptide binding]; other site
391165006947	active site
391165006948	GTP-binding protein Der; Reviewed; Region: PRK00093
391165006949	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
391165006950	G1 box; other site
391165006951	GTP/Mg2+ binding site [chemical binding]; other site
391165006952	Switch I region; other site
391165006953	G2 box; other site
391165006954	Switch II region; other site
391165006955	G3 box; other site
391165006956	G4 box; other site
391165006957	G5 box; other site
391165006958	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
391165006959	G1 box; other site
391165006960	GTP/Mg2+ binding site [chemical binding]; other site
391165006961	Switch I region; other site
391165006962	G2 box; other site
391165006963	G3 box; other site
391165006964	Switch II region; other site
391165006965	G4 box; other site
391165006966	G5 box; other site
391165006967	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
391165006968	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
391165006969	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
391165006970	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391165006971	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
391165006972	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
391165006973	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
391165006974	generic binding surface II; other site
391165006975	generic binding surface I; other site
391165006976	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
391165006977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391165006978	dimer interface [polypeptide binding]; other site
391165006979	conserved gate region; other site
391165006980	ABC-ATPase subunit interface; other site
391165006981	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
391165006982	NMT1-like family; Region: NMT1_2; pfam13379
391165006983	substrate binding pocket [chemical binding]; other site
391165006984	membrane-bound complex binding site; other site
391165006985	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
391165006986	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
391165006987	Walker A/P-loop; other site
391165006988	ATP binding site [chemical binding]; other site
391165006989	Q-loop/lid; other site
391165006990	ABC transporter signature motif; other site
391165006991	Walker B; other site
391165006992	D-loop; other site
391165006993	H-loop/switch region; other site
391165006994	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
391165006995	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
391165006996	active site
391165006997	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
391165006998	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
391165006999	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
391165007000	active site
391165007001	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
391165007002	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165007003	FeS/SAM binding site; other site
391165007004	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
391165007005	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
391165007006	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
391165007007	Membrane fusogenic activity; Region: BMFP; pfam04380
391165007008	Uncharacterized conserved protein [Function unknown]; Region: COG1565
391165007009	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
391165007010	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
391165007011	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
391165007012	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
391165007013	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391165007014	active site
391165007015	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391165007016	catalytic core [active]
391165007017	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
391165007018	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
391165007019	5S rRNA interface [nucleotide binding]; other site
391165007020	CTC domain interface [polypeptide binding]; other site
391165007021	L16 interface [polypeptide binding]; other site
391165007022	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
391165007023	putative active site [active]
391165007024	catalytic residue [active]
391165007025	GTP-binding protein YchF; Reviewed; Region: PRK09601
391165007026	YchF GTPase; Region: YchF; cd01900
391165007027	G1 box; other site
391165007028	GTP/Mg2+ binding site [chemical binding]; other site
391165007029	Switch I region; other site
391165007030	G2 box; other site
391165007031	Switch II region; other site
391165007032	G3 box; other site
391165007033	G4 box; other site
391165007034	G5 box; other site
391165007035	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
391165007036	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
391165007037	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
391165007038	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
391165007039	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
391165007040	active site
391165007041	metal binding site [ion binding]; metal-binding site
391165007042	Uncharacterized conserved protein [Function unknown]; Region: COG2353
391165007043	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
391165007044	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391165007045	DNA methylase; Region: N6_N4_Mtase; pfam01555
391165007046	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
391165007047	Cysteine-rich domain; Region: CCG; pfam02754
391165007048	Cysteine-rich domain; Region: CCG; pfam02754
391165007049	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
391165007050	active site
391165007051	catalytic site [active]
391165007052	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
391165007053	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
391165007054	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
391165007055	Smr domain; Region: Smr; pfam01713
391165007056	PAS fold; Region: PAS_4; pfam08448
391165007057	GAF domain; Region: GAF_3; pfam13492
391165007058	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
391165007059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165007060	dimer interface [polypeptide binding]; other site
391165007061	phosphorylation site [posttranslational modification]
391165007062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165007063	ATP binding site [chemical binding]; other site
391165007064	Mg2+ binding site [ion binding]; other site
391165007065	G-X-G motif; other site
391165007066	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
391165007067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165007068	active site
391165007069	phosphorylation site [posttranslational modification]
391165007070	intermolecular recognition site; other site
391165007071	dimerization interface [polypeptide binding]; other site
391165007072	Response regulator receiver domain; Region: Response_reg; pfam00072
391165007073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391165007074	active site
391165007075	phosphorylation site [posttranslational modification]
391165007076	intermolecular recognition site; other site
391165007077	dimerization interface [polypeptide binding]; other site
391165007078	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
391165007079	MltA specific insert domain; Region: MltA; smart00925
391165007080	3D domain; Region: 3D; pfam06725
391165007081	Tim44-like domain; Region: Tim44; pfam04280
391165007082	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391165007083	catalytic core [active]
391165007084	preprotein translocase subunit SecB; Validated; Region: PRK05751
391165007085	SecA binding site; other site
391165007086	Preprotein binding site; other site
391165007087	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391165007088	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391165007089	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
391165007090	putative substrate binding pocket [chemical binding]; other site
391165007091	putative dimerization interface [polypeptide binding]; other site
391165007092	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391165007093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391165007094	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
391165007095	Walker A/P-loop; other site
391165007096	ATP binding site [chemical binding]; other site
391165007097	Q-loop/lid; other site
391165007098	ABC transporter signature motif; other site
391165007099	Walker B; other site
391165007100	D-loop; other site
391165007101	H-loop/switch region; other site
391165007102	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
391165007103	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
391165007104	ligand binding site; other site
391165007105	oligomer interface; other site
391165007106	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
391165007107	dimer interface [polypeptide binding]; other site
391165007108	N-terminal domain interface [polypeptide binding]; other site
391165007109	sulfate 1 binding site; other site
391165007110	glycogen synthase; Provisional; Region: glgA; PRK00654
391165007111	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
391165007112	ADP-binding pocket [chemical binding]; other site
391165007113	homodimer interface [polypeptide binding]; other site
391165007114	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
391165007115	potassium uptake protein; Region: kup; TIGR00794
391165007116	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
391165007117	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391165007118	catalytic residue [active]
391165007119	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
391165007120	thiamine phosphate binding site [chemical binding]; other site
391165007121	active site
391165007122	pyrophosphate binding site [ion binding]; other site
391165007123	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
391165007124	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
391165007125	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
391165007126	putative NAD(P) binding site [chemical binding]; other site
391165007127	putative substrate binding site [chemical binding]; other site
391165007128	catalytic Zn binding site [ion binding]; other site
391165007129	structural Zn binding site [ion binding]; other site
391165007130	dimer interface [polypeptide binding]; other site
391165007131	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
391165007132	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
391165007133	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
391165007134	pyruvate dehydrogenase; Provisional; Region: PRK09124
391165007135	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
391165007136	PYR/PP interface [polypeptide binding]; other site
391165007137	tetramer interface [polypeptide binding]; other site
391165007138	dimer interface [polypeptide binding]; other site
391165007139	TPP binding site [chemical binding]; other site
391165007140	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
391165007141	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
391165007142	TPP-binding site [chemical binding]; other site
391165007143	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
391165007144	FMN binding site [chemical binding]; other site
391165007145	substrate binding site [chemical binding]; other site
391165007146	putative catalytic residue [active]
391165007147	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
391165007148	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
391165007149	RNase E interface [polypeptide binding]; other site
391165007150	trimer interface [polypeptide binding]; other site
391165007151	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
391165007152	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
391165007153	RNase E interface [polypeptide binding]; other site
391165007154	trimer interface [polypeptide binding]; other site
391165007155	active site
391165007156	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
391165007157	putative nucleic acid binding region [nucleotide binding]; other site
391165007158	G-X-X-G motif; other site
391165007159	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
391165007160	RNA binding site [nucleotide binding]; other site
391165007161	domain interface; other site
391165007162	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
391165007163	16S/18S rRNA binding site [nucleotide binding]; other site
391165007164	S13e-L30e interaction site [polypeptide binding]; other site
391165007165	25S rRNA binding site [nucleotide binding]; other site
391165007166	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
391165007167	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
391165007168	RNA binding site [nucleotide binding]; other site
391165007169	active site
391165007170	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
391165007171	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
391165007172	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
391165007173	NADP-binding site; other site
391165007174	homotetramer interface [polypeptide binding]; other site
391165007175	substrate binding site [chemical binding]; other site
391165007176	homodimer interface [polypeptide binding]; other site
391165007177	active site
391165007178	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
391165007179	Transglycosylase; Region: Transgly; pfam00912
391165007180	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
391165007181	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
391165007182	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
391165007183	MG2 domain; Region: A2M_N; pfam01835
391165007184	Alpha-2-macroglobulin family; Region: A2M; pfam00207
391165007185	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
391165007186	surface patch; other site
391165007187	thioester region; other site
391165007188	specificity defining residues; other site
391165007189	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
391165007190	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391165007191	putative acyl-acceptor binding pocket; other site
391165007192	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
391165007193	acyl-activating enzyme (AAE) consensus motif; other site
391165007194	putative AMP binding site [chemical binding]; other site
391165007195	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
391165007196	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
391165007197	putative FMN binding site [chemical binding]; other site
391165007198	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
391165007199	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391165007200	dimer interface [polypeptide binding]; other site
391165007201	phosphorylation site [posttranslational modification]
391165007202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391165007203	ATP binding site [chemical binding]; other site
391165007204	Mg2+ binding site [ion binding]; other site
391165007205	G-X-G motif; other site
391165007206	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
391165007207	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
391165007208	putative ligand binding site [chemical binding]; other site
391165007209	Predicted methyltransferases [General function prediction only]; Region: COG0313
391165007210	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
391165007211	putative homodimer interface [polypeptide binding]; other site
391165007212	putative SAM binding site [chemical binding]; other site
391165007213	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
391165007214	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
391165007215	active site
391165007216	dimer interface [polypeptide binding]; other site
391165007217	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391165007218	active site
391165007219	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
391165007220	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
391165007221	GTP binding site; other site
391165007222	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
391165007223	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391165007224	substrate binding pocket [chemical binding]; other site
391165007225	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391165007226	malate synthase G; Provisional; Region: PRK02999
391165007227	active site
391165007228	Phosphoglycerate mutase family; Region: PGAM; smart00855
391165007229	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391165007230	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
391165007231	Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490
391165007232	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
391165007233	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391165007234	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
391165007235	IucA / IucC family; Region: IucA_IucC; pfam04183
391165007236	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
391165007237	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
391165007238	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
391165007239	IucA / IucC family; Region: IucA_IucC; pfam04183
391165007240	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
391165007241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391165007242	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391165007243	putative substrate translocation pore; other site
391165007244	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
391165007245	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
391165007246	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
391165007247	hydrogenase 4 subunit B; Validated; Region: PRK06521
391165007248	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
391165007249	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
391165007250	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
391165007251	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
391165007252	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
391165007253	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
391165007254	Probable Catalytic site; other site
391165007255	metal-binding site
391165007256	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391165007257	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
391165007258	Probable Catalytic site; other site
391165007259	metal-binding site
391165007260	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
391165007261	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
391165007262	translation initiation factor IF-2; Region: IF-2; TIGR00487
391165007263	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
391165007264	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
391165007265	G1 box; other site
391165007266	putative GEF interaction site [polypeptide binding]; other site
391165007267	GTP/Mg2+ binding site [chemical binding]; other site
391165007268	Switch I region; other site
391165007269	G2 box; other site
391165007270	G3 box; other site
391165007271	Switch II region; other site
391165007272	G4 box; other site
391165007273	G5 box; other site
391165007274	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
391165007275	Translation-initiation factor 2; Region: IF-2; pfam11987
391165007276	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
391165007277	hypothetical protein; Provisional; Region: PRK09190
391165007278	Protein of unknown function (DUF448); Region: DUF448; pfam04296
391165007279	putative RNA binding cleft [nucleotide binding]; other site
391165007280	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
391165007281	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
391165007282	NusA N-terminal domain; Region: NusA_N; pfam08529
391165007283	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
391165007284	RNA binding site [nucleotide binding]; other site
391165007285	homodimer interface [polypeptide binding]; other site
391165007286	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
391165007287	G-X-X-G motif; other site
391165007288	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
391165007289	G-X-X-G motif; other site
391165007290	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
391165007291	ribosome maturation protein RimP; Reviewed; Region: PRK00092
391165007292	Sm and related proteins; Region: Sm_like; cl00259
391165007293	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
391165007294	putative oligomer interface [polypeptide binding]; other site
391165007295	putative RNA binding site [nucleotide binding]; other site
391165007296	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
391165007297	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
391165007298	Domain of unknown function DUF20; Region: UPF0118; pfam01594
391165007299	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
391165007300	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
391165007301	S-adenosylmethionine synthetase; Validated; Region: PRK05250
391165007302	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
391165007303	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
391165007304	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
391165007305	putative active site [active]
391165007306	YdjC motif; other site
391165007307	Mg binding site [ion binding]; other site
391165007308	putative homodimer interface [polypeptide binding]; other site
391165007309	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
391165007310	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
391165007311	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165007312	FeS/SAM binding site; other site
391165007313	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
391165007314	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
391165007315	ligand binding site; other site
391165007316	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
391165007317	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
391165007318	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
391165007319	TPP-binding site; other site
391165007320	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
391165007321	PYR/PP interface [polypeptide binding]; other site
391165007322	dimer interface [polypeptide binding]; other site
391165007323	TPP binding site [chemical binding]; other site
391165007324	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391165007325	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
391165007326	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391165007327	FeS/SAM binding site; other site
391165007328	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
391165007329	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
391165007330	dihydrodipicolinate reductase; Provisional; Region: PRK00048
391165007331	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
391165007332	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
391165007333	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
391165007334	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
391165007335	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391165007336	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391165007337	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
391165007338	homodimer interface [polypeptide binding]; other site
391165007339	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
391165007340	active site pocket [active]
391165007341	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
391165007342	active site
391165007343	HIGH motif; other site
391165007344	dimer interface [polypeptide binding]; other site
391165007345	KMSKS motif; other site
391165007346	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
391165007347	Ligand binding site; other site
391165007348	Putative Catalytic site; other site
391165007349	DXD motif; other site
391165007350	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
391165007351	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391165007352	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
391165007353	methionine sulfoxide reductase A; Provisional; Region: PRK14054
391165007354	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
391165007355	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
391165007356	active site
391165007357	non-prolyl cis peptide bond; other site
391165007358	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
391165007359	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
391165007360	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
391165007361	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
391165007362	active site
391165007363	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
391165007364	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
391165007365	domain interfaces; other site
391165007366	active site
391165007367	UGMP family protein; Validated; Region: PRK09604
391165007368	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
391165007369	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
391165007370	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
391165007371	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
391165007372	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
391165007373	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
391165007374	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391165007375	minor groove reading motif; other site
391165007376	helix-hairpin-helix signature motif; other site
391165007377	substrate binding pocket [chemical binding]; other site
391165007378	active site
391165007379	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
391165007380	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
391165007381	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
391165007382	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
391165007383	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
391165007384	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
391165007385	Ferrochelatase; Region: Ferrochelatase; pfam00762
391165007386	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
391165007387	C-terminal domain interface [polypeptide binding]; other site
391165007388	active site
391165007389	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
391165007390	active site
391165007391	N-terminal domain interface [polypeptide binding]; other site
391165007392	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
391165007393	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
391165007394	ATP binding site [chemical binding]; other site
391165007395	Mg++ binding site [ion binding]; other site
391165007396	motif III; other site
391165007397	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391165007398	nucleotide binding region [chemical binding]; other site
391165007399	ATP-binding site [chemical binding]; other site