-- dump date 20140619_104016 -- class Genbank::misc_feature -- table misc_feature_note -- id note 682795000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 682795000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 682795000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795000004 Walker A motif; other site 682795000005 ATP binding site [chemical binding]; other site 682795000006 Walker B motif; other site 682795000007 arginine finger; other site 682795000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 682795000009 DnaA box-binding interface [nucleotide binding]; other site 682795000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 682795000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 682795000012 putative DNA binding surface [nucleotide binding]; other site 682795000013 dimer interface [polypeptide binding]; other site 682795000014 beta-clamp/clamp loader binding surface; other site 682795000015 beta-clamp/translesion DNA polymerase binding surface; other site 682795000016 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 682795000017 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 682795000018 Walker A/P-loop; other site 682795000019 ATP binding site [chemical binding]; other site 682795000020 Q-loop/lid; other site 682795000021 ABC transporter signature motif; other site 682795000022 Walker B; other site 682795000023 D-loop; other site 682795000024 H-loop/switch region; other site 682795000025 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 682795000026 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 682795000027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795000028 dimer interface [polypeptide binding]; other site 682795000029 conserved gate region; other site 682795000030 putative PBP binding loops; other site 682795000031 ABC-ATPase subunit interface; other site 682795000032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795000033 dimer interface [polypeptide binding]; other site 682795000034 conserved gate region; other site 682795000035 putative PBP binding loops; other site 682795000036 ABC-ATPase subunit interface; other site 682795000037 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 682795000038 beta-galactosidase; Region: BGL; TIGR03356 682795000039 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000040 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795000041 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795000042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795000043 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 682795000044 dimerization interface [polypeptide binding]; other site 682795000045 substrate binding pocket [chemical binding]; other site 682795000046 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 682795000047 Cupin; Region: Cupin_1; smart00835 682795000048 Cupin; Region: Cupin_1; smart00835 682795000049 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 682795000050 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 682795000051 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 682795000052 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795000053 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 682795000054 peptide chain release factor 1; Validated; Region: prfA; PRK00591 682795000055 PCRF domain; Region: PCRF; pfam03462 682795000056 RF-1 domain; Region: RF-1; pfam00472 682795000057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 682795000058 Peptidase M15; Region: Peptidase_M15_3; cl01194 682795000059 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 682795000060 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 682795000061 iron-sulfur cluster [ion binding]; other site 682795000062 [2Fe-2S] cluster binding site [ion binding]; other site 682795000063 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 682795000064 hydrophobic ligand binding site; other site 682795000065 methionine sulfoxide reductase A; Provisional; Region: PRK13014 682795000066 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 682795000067 Protein of unknown function (DUF433); Region: DUF433; pfam04255 682795000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 682795000069 HindIII restriction endonuclease; Region: RE_HindIII; pfam09518 682795000070 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 682795000071 DNA methylase; Region: N6_N4_Mtase; pfam01555 682795000072 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 682795000073 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 682795000074 CAP-like domain; other site 682795000075 active site 682795000076 primary dimer interface [polypeptide binding]; other site 682795000077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 682795000078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 682795000079 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 682795000080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 682795000081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 682795000082 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 682795000083 active site 682795000084 phosphate binding residues; other site 682795000085 catalytic residues [active] 682795000086 Maf-like protein; Region: Maf; pfam02545 682795000087 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 682795000088 active site 682795000089 dimer interface [polypeptide binding]; other site 682795000090 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 682795000091 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 682795000092 active site 682795000093 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 682795000094 GIY-YIG motif/motif A; other site 682795000095 putative active site [active] 682795000096 putative metal binding site [ion binding]; other site 682795000097 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 682795000098 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 682795000099 helix-hairpin-helix signature motif; other site 682795000100 substrate binding pocket [chemical binding]; other site 682795000101 active site 682795000102 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 682795000103 active site 682795000104 dimer interface [polypeptide binding]; other site 682795000105 catalytic nucleophile [active] 682795000106 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 682795000107 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 682795000108 metal binding site [ion binding]; metal-binding site 682795000109 dimer interface [polypeptide binding]; other site 682795000110 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 682795000111 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 682795000112 DinB superfamily; Region: DinB_2; pfam12867 682795000113 DinB family; Region: DinB; cl17821 682795000114 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 682795000115 catalytic center binding site [active] 682795000116 ATP binding site [chemical binding]; other site 682795000117 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 682795000118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 682795000119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795000120 non-specific DNA binding site [nucleotide binding]; other site 682795000121 salt bridge; other site 682795000122 sequence-specific DNA binding site [nucleotide binding]; other site 682795000123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 682795000124 hypothetical protein; Provisional; Region: PRK07208 682795000125 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 682795000126 Clp amino terminal domain; Region: Clp_N; pfam02861 682795000127 Clp amino terminal domain; Region: Clp_N; pfam02861 682795000128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795000129 Walker A motif; other site 682795000130 ATP binding site [chemical binding]; other site 682795000131 Walker B motif; other site 682795000132 arginine finger; other site 682795000133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795000134 Walker A motif; other site 682795000135 ATP binding site [chemical binding]; other site 682795000136 Walker B motif; other site 682795000137 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 682795000138 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 682795000139 Alginate lyase; Region: Alginate_lyase; pfam05426 682795000140 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795000141 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 682795000142 PA/protease or protease-like domain interface [polypeptide binding]; other site 682795000143 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 682795000144 Peptidase family M28; Region: Peptidase_M28; pfam04389 682795000145 metal binding site [ion binding]; metal-binding site 682795000146 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 682795000147 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 682795000148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795000149 binding surface 682795000150 TPR motif; other site 682795000151 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 682795000152 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 682795000153 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 682795000154 putative acyl-acceptor binding pocket; other site 682795000155 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 682795000156 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 682795000157 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 682795000158 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 682795000159 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 682795000160 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 682795000161 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 682795000162 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 682795000163 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 682795000164 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 682795000165 AP (apurinic/apyrimidinic) site pocket; other site 682795000166 DNA interaction; other site 682795000167 Metal-binding active site; metal-binding site 682795000168 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 682795000169 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 682795000170 putative dimer interface [polypeptide binding]; other site 682795000171 putative anticodon binding site; other site 682795000172 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 682795000173 homodimer interface [polypeptide binding]; other site 682795000174 motif 1; other site 682795000175 motif 2; other site 682795000176 active site 682795000177 motif 3; other site 682795000178 TROVE domain; Region: TROVE; pfam05731 682795000179 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795000180 metal ion-dependent adhesion site (MIDAS); other site 682795000181 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 682795000182 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 682795000183 putative active site [active] 682795000184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795000186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000187 DinB superfamily; Region: DinB_2; pfam12867 682795000188 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 682795000189 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 682795000190 Transcriptional regulators [Transcription]; Region: MarR; COG1846 682795000191 MarR family; Region: MarR_2; pfam12802 682795000192 MarR family; Region: MarR_2; cl17246 682795000193 GTP-binding protein YchF; Reviewed; Region: PRK09601 682795000194 YchF GTPase; Region: YchF; cd01900 682795000195 G1 box; other site 682795000196 GTP/Mg2+ binding site [chemical binding]; other site 682795000197 Switch I region; other site 682795000198 G2 box; other site 682795000199 Switch II region; other site 682795000200 G3 box; other site 682795000201 G4 box; other site 682795000202 G5 box; other site 682795000203 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 682795000204 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 682795000205 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 682795000206 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 682795000207 threonine dehydratase; Provisional; Region: PRK08198 682795000208 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 682795000209 tetramer interface [polypeptide binding]; other site 682795000210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795000211 catalytic residue [active] 682795000212 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 682795000213 TIGR03118 family protein; Region: PEPCTERM_chp_1 682795000214 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000215 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795000216 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 682795000217 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 682795000218 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 682795000219 Penicillinase repressor; Region: Pencillinase_R; pfam03965 682795000220 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 682795000221 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795000222 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 682795000223 FAD binding domain; Region: FAD_binding_4; pfam01565 682795000224 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 682795000225 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 682795000226 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 682795000227 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 682795000228 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 682795000229 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 682795000230 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 682795000231 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 682795000232 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 682795000233 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 682795000234 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 682795000235 metal binding site 2 [ion binding]; metal-binding site 682795000236 putative DNA binding helix; other site 682795000237 metal binding site 1 [ion binding]; metal-binding site 682795000238 dimer interface [polypeptide binding]; other site 682795000239 structural Zn2+ binding site [ion binding]; other site 682795000240 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 682795000241 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 682795000242 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795000243 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 682795000244 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 682795000245 Multicopper oxidase; Region: Cu-oxidase; pfam00394 682795000246 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 682795000247 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 682795000248 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 682795000249 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000250 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795000251 Transcriptional regulator [Transcription]; Region: IclR; COG1414 682795000252 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 682795000253 Bacterial transcriptional regulator; Region: IclR; pfam01614 682795000254 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 682795000255 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 682795000256 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 682795000257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795000258 dimerization interface [polypeptide binding]; other site 682795000259 putative DNA binding site [nucleotide binding]; other site 682795000260 putative Zn2+ binding site [ion binding]; other site 682795000261 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 682795000262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000263 NAD(P) binding site [chemical binding]; other site 682795000264 active site 682795000265 short chain dehydrogenase; Provisional; Region: PRK06500 682795000266 classical (c) SDRs; Region: SDR_c; cd05233 682795000267 NAD(P) binding site [chemical binding]; other site 682795000268 active site 682795000269 chorismate mutase; Provisional; Region: PRK09269 682795000270 Chorismate mutase type II; Region: CM_2; cl00693 682795000271 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 682795000272 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 682795000273 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 682795000274 Beta-lactamase; Region: Beta-lactamase; pfam00144 682795000275 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 682795000276 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 682795000277 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 682795000278 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 682795000279 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 682795000280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795000281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795000282 Chloramphenicol acetyltransferase; Region: CAT; cl02008 682795000283 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 682795000284 short chain dehydrogenase; Provisional; Region: PRK06500 682795000285 classical (c) SDRs; Region: SDR_c; cd05233 682795000286 NAD(P) binding site [chemical binding]; other site 682795000287 active site 682795000288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795000289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795000290 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 682795000291 active site 682795000292 ATP binding site [chemical binding]; other site 682795000293 Phosphotransferase enzyme family; Region: APH; pfam01636 682795000294 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000295 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 682795000296 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795000297 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 682795000298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795000299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 682795000300 dimerization interface [polypeptide binding]; other site 682795000301 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795000302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000303 NAD(P) binding site [chemical binding]; other site 682795000304 active site 682795000305 Cupin; Region: Cupin_6; pfam12852 682795000306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000307 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795000308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000309 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 682795000310 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795000311 putative NAD(P) binding site [chemical binding]; other site 682795000312 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 682795000313 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795000314 catalytic residues [active] 682795000315 Predicted transcriptional regulators [Transcription]; Region: COG1695 682795000316 Transcriptional regulator PadR-like family; Region: PadR; cl17335 682795000317 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 682795000318 dimer interface [polypeptide binding]; other site 682795000319 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 682795000320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795000321 DNA-binding site [nucleotide binding]; DNA binding site 682795000322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795000323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795000324 homodimer interface [polypeptide binding]; other site 682795000325 catalytic residue [active] 682795000326 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 682795000327 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 682795000328 dimer interface [polypeptide binding]; other site 682795000329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795000330 catalytic residue [active] 682795000331 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 682795000332 CoenzymeA binding site [chemical binding]; other site 682795000333 subunit interaction site [polypeptide binding]; other site 682795000334 PHB binding site; other site 682795000335 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 682795000336 B12 binding site [chemical binding]; other site 682795000337 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 682795000338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795000339 FeS/SAM binding site; other site 682795000340 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 682795000341 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 682795000342 active site residue [active] 682795000343 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 682795000344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795000345 putative DNA binding site [nucleotide binding]; other site 682795000346 putative Zn2+ binding site [ion binding]; other site 682795000347 AsnC family; Region: AsnC_trans_reg; pfam01037 682795000348 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 682795000349 EamA-like transporter family; Region: EamA; pfam00892 682795000350 EamA-like transporter family; Region: EamA; pfam00892 682795000351 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 682795000352 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000353 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 682795000355 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 682795000356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795000357 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 682795000358 YCII-related domain; Region: YCII; cl00999 682795000359 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 682795000360 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 682795000361 ligand binding site [chemical binding]; other site 682795000362 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 682795000363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795000364 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 682795000365 dimerization interface [polypeptide binding]; other site 682795000366 substrate binding pocket [chemical binding]; other site 682795000367 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795000368 classical (c) SDRs; Region: SDR_c; cd05233 682795000369 NAD(P) binding site [chemical binding]; other site 682795000370 active site 682795000371 Trehalase; Region: Trehalase; cl17346 682795000372 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 682795000373 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000374 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795000375 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795000376 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 682795000377 active site 682795000378 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 682795000379 active site 682795000380 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 682795000381 Helix-turn-helix domain; Region: HTH_18; pfam12833 682795000382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000383 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795000384 M28 Zn-Peptidases; Region: M28_like_4; cd08015 682795000385 Peptidase family M28; Region: Peptidase_M28; pfam04389 682795000386 metal binding site [ion binding]; metal-binding site 682795000387 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 682795000388 putative active site [active] 682795000389 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 682795000390 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 682795000391 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 682795000392 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 682795000393 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 682795000394 Walker A/P-loop; other site 682795000395 ATP binding site [chemical binding]; other site 682795000396 Q-loop/lid; other site 682795000397 ABC transporter signature motif; other site 682795000398 Walker B; other site 682795000399 D-loop; other site 682795000400 H-loop/switch region; other site 682795000401 NMT1/THI5 like; Region: NMT1; pfam09084 682795000402 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 682795000403 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 682795000404 malonyl-CoA binding site [chemical binding]; other site 682795000405 dimer interface [polypeptide binding]; other site 682795000406 active site 682795000407 product binding site; other site 682795000408 Methyltransferase domain; Region: Methyltransf_23; pfam13489 682795000409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795000410 S-adenosylmethionine binding site [chemical binding]; other site 682795000411 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 682795000412 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 682795000413 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 682795000414 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795000415 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 682795000416 FtsX-like permease family; Region: FtsX; pfam02687 682795000417 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795000418 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 682795000419 FtsX-like permease family; Region: FtsX; pfam02687 682795000420 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 682795000421 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 682795000422 ligand binding site; other site 682795000423 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795000424 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 682795000425 ligand binding site [chemical binding]; other site 682795000426 flexible hinge region; other site 682795000427 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 682795000428 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 682795000429 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 682795000430 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 682795000431 [2Fe-2S] cluster binding site [ion binding]; other site 682795000432 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 682795000433 hydrophobic ligand binding site; other site 682795000434 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 682795000435 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 682795000436 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 682795000437 active site 682795000438 catalytic site [active] 682795000439 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 682795000440 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 682795000441 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 682795000442 endonuclease III; Region: ENDO3c; smart00478 682795000443 minor groove reading motif; other site 682795000444 helix-hairpin-helix signature motif; other site 682795000445 substrate binding pocket [chemical binding]; other site 682795000446 active site 682795000447 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 682795000448 heme-binding residues [chemical binding]; other site 682795000449 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 682795000450 molybdopterin cofactor binding site; other site 682795000451 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 682795000452 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 682795000453 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 682795000454 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 682795000455 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 682795000456 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 682795000457 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 682795000458 Cu(I) binding site [ion binding]; other site 682795000459 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 682795000460 Cytochrome c; Region: Cytochrom_C; pfam00034 682795000461 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 682795000462 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 682795000463 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 682795000464 Subunit I/III interface [polypeptide binding]; other site 682795000465 caa(3)-type oxidase, subunit IV; Region: caa3_sub_IV; TIGR02229 682795000466 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 682795000467 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 682795000468 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 682795000469 CHC2 zinc finger; Region: zf-CHC2; pfam01807 682795000470 DNA primase; Validated; Region: dnaG; PRK05667 682795000471 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 682795000472 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 682795000473 active site 682795000474 metal binding site [ion binding]; metal-binding site 682795000475 interdomain interaction site; other site 682795000476 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 682795000477 UGMP family protein; Validated; Region: PRK09604 682795000478 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 682795000479 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 682795000480 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 682795000481 active site 682795000482 NTP binding site [chemical binding]; other site 682795000483 metal binding triad [ion binding]; metal-binding site 682795000484 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 682795000485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 682795000486 Zn2+ binding site [ion binding]; other site 682795000487 Mg2+ binding site [ion binding]; other site 682795000488 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 682795000489 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 682795000490 nucleoside/Zn binding site; other site 682795000491 dimer interface [polypeptide binding]; other site 682795000492 catalytic motif [active] 682795000493 Uncharacterized conserved protein [Function unknown]; Region: COG3542 682795000494 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 682795000495 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 682795000496 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 682795000497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 682795000498 hydroxyglutarate oxidase; Provisional; Region: PRK11728 682795000499 Pectic acid lyase; Region: Pec_lyase; pfam09492 682795000500 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 682795000501 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 682795000502 Sporulation related domain; Region: SPOR; pfam05036 682795000503 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 682795000504 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795000505 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795000506 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795000507 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795000508 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795000509 Surface antigen; Region: Bac_surface_Ag; pfam01103 682795000510 exosortase J; Region: exosort_xrtJ; TIGR04199 682795000511 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 682795000512 XrtJ-associated TM-motif-TM protein; Region: targ_of_XrtJ; TIGR04200 682795000513 ribosome recycling factor; Reviewed; Region: frr; PRK00083 682795000514 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 682795000515 hinge region; other site 682795000516 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 682795000517 dihydropteroate synthase; Region: DHPS; TIGR01496 682795000518 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 682795000519 substrate binding pocket [chemical binding]; other site 682795000520 dimer interface [polypeptide binding]; other site 682795000521 inhibitor binding site; inhibition site 682795000522 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 682795000523 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; cl01770 682795000524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 682795000525 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 682795000526 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 682795000527 Predicted transcriptional regulator [Transcription]; Region: COG2378 682795000528 HTH domain; Region: HTH_11; pfam08279 682795000529 WYL domain; Region: WYL; pfam13280 682795000530 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 682795000531 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 682795000532 oligomeric interface; other site 682795000533 putative active site [active] 682795000534 homodimer interface [polypeptide binding]; other site 682795000535 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 682795000536 replicative DNA helicase; Region: DnaB; TIGR00665 682795000537 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 682795000538 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 682795000539 Walker A motif; other site 682795000540 ATP binding site [chemical binding]; other site 682795000541 Walker B motif; other site 682795000542 DNA binding loops [nucleotide binding] 682795000543 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 682795000544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795000545 catalytic residue [active] 682795000546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795000547 S-adenosylmethionine binding site [chemical binding]; other site 682795000548 Yqey-like protein; Region: YqeY; pfam09424 682795000549 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795000550 Amidase; Region: Amidase; cl11426 682795000551 YCII-related domain; Region: YCII; pfam03795 682795000552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795000553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795000554 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 682795000555 oligomeric interface; other site 682795000556 putative active site [active] 682795000557 homodimer interface [polypeptide binding]; other site 682795000558 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 682795000559 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 682795000560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000562 Outer membrane efflux protein; Region: OEP; pfam02321 682795000563 Outer membrane efflux protein; Region: OEP; pfam02321 682795000564 multidrug resistance protein MdtN; Provisional; Region: PRK10476 682795000565 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795000566 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 682795000567 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 682795000568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000569 NADH(P)-binding; Region: NAD_binding_10; pfam13460 682795000570 NAD(P) binding site [chemical binding]; other site 682795000571 active site 682795000572 Cupin domain; Region: Cupin_2; pfam07883 682795000573 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 682795000574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795000575 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 682795000576 DNA binding residues [nucleotide binding] 682795000577 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 682795000578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795000579 FeS/SAM binding site; other site 682795000580 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 682795000581 aminodeoxychorismate synthase; Provisional; Region: PRK07508 682795000582 chorismate binding enzyme; Region: Chorismate_bind; cl10555 682795000583 hypothetical protein; Provisional; Region: PRK07546 682795000584 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 682795000585 substrate-cofactor binding pocket; other site 682795000586 homodimer interface [polypeptide binding]; other site 682795000587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795000588 catalytic residue [active] 682795000589 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 682795000590 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 682795000591 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 682795000592 Moco binding site; other site 682795000593 metal coordination site [ion binding]; other site 682795000594 Methyltransferase domain; Region: Methyltransf_31; pfam13847 682795000595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795000596 S-adenosylmethionine binding site [chemical binding]; other site 682795000597 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 682795000598 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 682795000599 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 682795000600 Ligand binding site; other site 682795000601 Putative Catalytic site; other site 682795000602 DXD motif; other site 682795000603 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795000604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000605 NAD(P) binding site [chemical binding]; other site 682795000606 active site 682795000607 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 682795000608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795000609 ATP binding site [chemical binding]; other site 682795000610 Mg2+ binding site [ion binding]; other site 682795000611 G-X-G motif; other site 682795000612 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 682795000613 anchoring element; other site 682795000614 dimer interface [polypeptide binding]; other site 682795000615 ATP binding site [chemical binding]; other site 682795000616 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 682795000617 active site 682795000618 putative metal-binding site [ion binding]; other site 682795000619 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 682795000620 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 682795000621 amphipathic channel; other site 682795000622 Asn-Pro-Ala signature motifs; other site 682795000623 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 682795000624 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 682795000625 putative active site [active] 682795000626 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 682795000627 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 682795000628 active site 682795000629 Zn binding site [ion binding]; other site 682795000630 Acyltransferase family; Region: Acyl_transf_3; pfam01757 682795000631 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 682795000632 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 682795000633 23S rRNA binding site [nucleotide binding]; other site 682795000634 L21 binding site [polypeptide binding]; other site 682795000635 L13 binding site [polypeptide binding]; other site 682795000636 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 682795000637 putative active site [active] 682795000638 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 682795000639 FAD binding domain; Region: FAD_binding_4; pfam01565 682795000640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000641 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 682795000642 NAD(P) binding site [chemical binding]; other site 682795000643 active site 682795000644 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795000646 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795000647 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795000648 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795000649 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 682795000650 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 682795000651 catalytic core [active] 682795000652 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 682795000653 Putative zinc-finger; Region: zf-HC2; pfam13490 682795000654 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 682795000655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 682795000656 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 682795000657 active site 682795000658 catalytic triad [active] 682795000659 oxyanion hole [active] 682795000660 Predicted transcriptional regulators [Transcription]; Region: COG1733 682795000661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795000662 putative DNA binding site [nucleotide binding]; other site 682795000663 putative Zn2+ binding site [ion binding]; other site 682795000664 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 682795000665 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 682795000666 FMN binding site [chemical binding]; other site 682795000667 active site 682795000668 substrate binding site [chemical binding]; other site 682795000669 catalytic residue [active] 682795000670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795000671 binding surface 682795000672 TPR motif; other site 682795000673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795000674 Coenzyme A binding pocket [chemical binding]; other site 682795000675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795000676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795000677 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795000678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000679 NAD(P) binding site [chemical binding]; other site 682795000680 active site 682795000681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000682 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795000683 NAD(P) binding site [chemical binding]; other site 682795000684 active site 682795000685 Domain of unknown function (DUF427); Region: DUF427; pfam04248 682795000686 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 682795000687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000688 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 682795000689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795000691 short chain dehydrogenase; Provisional; Region: PRK12937 682795000692 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 682795000693 NADP binding site [chemical binding]; other site 682795000694 homodimer interface [polypeptide binding]; other site 682795000695 active site 682795000696 substrate binding site [chemical binding]; other site 682795000697 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 682795000698 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 682795000699 NADP binding site [chemical binding]; other site 682795000700 active site 682795000701 steroid binding site; other site 682795000702 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 682795000703 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 682795000704 SIR2-like domain; Region: SIR2_2; pfam13289 682795000705 TIGR02646 family protein; Region: TIGR02646 682795000706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795000707 AAA domain; Region: AAA_21; pfam13304 682795000708 Walker A/P-loop; other site 682795000709 ATP binding site [chemical binding]; other site 682795000710 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 682795000711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795000712 FeS/SAM binding site; other site 682795000713 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 682795000714 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 682795000715 HEXXH motif domain; Region: mod_HExxH; TIGR04267 682795000716 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 682795000717 ParB-like nuclease domain; Region: ParBc; pfam02195 682795000718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795000719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795000720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 682795000721 dimerization interface [polypeptide binding]; other site 682795000722 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 682795000723 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 682795000724 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 682795000725 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 682795000726 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 682795000727 active site 682795000728 catalytic residues [active] 682795000729 DNA binding site [nucleotide binding] 682795000730 Int/Topo IB signature motif; other site 682795000731 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 682795000732 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795000733 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795000734 DNA binding residues [nucleotide binding] 682795000735 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 682795000736 tetratricopeptide repeat protein; Provisional; Region: PRK11788 682795000737 ribonuclease III; Reviewed; Region: rnc; PRK00102 682795000738 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 682795000739 dimerization interface [polypeptide binding]; other site 682795000740 active site 682795000741 metal binding site [ion binding]; metal-binding site 682795000742 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 682795000743 dsRNA binding site [nucleotide binding]; other site 682795000744 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 682795000745 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 682795000746 Catalytic site [active] 682795000747 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 682795000748 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 682795000749 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 682795000750 Catalytic site [active] 682795000751 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 682795000752 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 682795000753 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 682795000754 Catalytic site [active] 682795000755 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 682795000756 AsmA family; Region: AsmA; pfam05170 682795000757 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795000758 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795000759 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795000760 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 682795000761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795000762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795000763 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 682795000764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795000765 dimer interface [polypeptide binding]; other site 682795000766 phosphorylation site [posttranslational modification] 682795000767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795000768 ATP binding site [chemical binding]; other site 682795000769 Mg2+ binding site [ion binding]; other site 682795000770 G-X-G motif; other site 682795000771 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 682795000772 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 682795000773 Ligand Binding Site [chemical binding]; other site 682795000774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795000775 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 682795000776 putative ADP-binding pocket [chemical binding]; other site 682795000777 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 682795000778 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 682795000779 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 682795000780 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 682795000781 Soluble P-type ATPase [General function prediction only]; Region: COG4087 682795000782 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 682795000783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795000784 binding surface 682795000785 TPR motif; other site 682795000786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795000787 TPR repeat; Region: TPR_11; pfam13414 682795000788 binding surface 682795000789 TPR motif; other site 682795000790 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 682795000791 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 682795000792 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 682795000793 metal ion-dependent adhesion site (MIDAS); other site 682795000794 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 682795000795 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 682795000796 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 682795000797 2-methylcitrate dehydratase; Region: prpD; TIGR02330 682795000798 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 682795000799 methylcitrate synthase; Provisional; Region: PRK12351 682795000800 oxalacetate binding site [chemical binding]; other site 682795000801 citrylCoA binding site [chemical binding]; other site 682795000802 coenzyme A binding site [chemical binding]; other site 682795000803 catalytic triad [active] 682795000804 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 682795000805 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 682795000806 tetramer interface [polypeptide binding]; other site 682795000807 active site 682795000808 Mg2+/Mn2+ binding site [ion binding]; other site 682795000809 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 682795000810 active site 682795000811 metal binding site [ion binding]; metal-binding site 682795000812 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 682795000813 BON domain; Region: BON; pfam04972 682795000814 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 682795000815 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 682795000816 dimer interface [polypeptide binding]; other site 682795000817 active site 682795000818 acyl carrier protein; Provisional; Region: acpP; PRK00982 682795000819 RmuC family; Region: RmuC; pfam02646 682795000820 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 682795000821 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 682795000822 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 682795000823 catalytic residues [active] 682795000824 Radical SAM superfamily; Region: Radical_SAM; pfam04055 682795000825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795000826 FeS/SAM binding site; other site 682795000827 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 682795000828 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 682795000829 integral membrane protein MviN; Region: mviN; TIGR01695 682795000830 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 682795000831 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 682795000832 DNA binding residues [nucleotide binding] 682795000833 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 682795000834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 682795000835 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 682795000836 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 682795000837 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 682795000838 active site 682795000839 HIGH motif; other site 682795000840 dimer interface [polypeptide binding]; other site 682795000841 KMSKS motif; other site 682795000842 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795000843 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795000844 active site 682795000845 catalytic tetrad [active] 682795000846 Protein of unknown function (DUF419); Region: DUF419; cl15265 682795000847 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795000848 classical (c) SDRs; Region: SDR_c; cd05233 682795000849 NAD(P) binding site [chemical binding]; other site 682795000850 active site 682795000851 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 682795000852 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 682795000853 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 682795000854 active site 682795000855 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 682795000856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 682795000857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795000858 non-specific DNA binding site [nucleotide binding]; other site 682795000859 salt bridge; other site 682795000860 sequence-specific DNA binding site [nucleotide binding]; other site 682795000861 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 682795000862 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 682795000863 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 682795000864 catalytic triad [active] 682795000865 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 682795000866 N-acetyl-D-glucosamine binding site [chemical binding]; other site 682795000867 catalytic residue [active] 682795000868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 682795000869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 682795000870 GTP-binding protein LepA; Provisional; Region: PRK05433 682795000871 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 682795000872 G1 box; other site 682795000873 putative GEF interaction site [polypeptide binding]; other site 682795000874 GTP/Mg2+ binding site [chemical binding]; other site 682795000875 Switch I region; other site 682795000876 G2 box; other site 682795000877 G3 box; other site 682795000878 Switch II region; other site 682795000879 G4 box; other site 682795000880 G5 box; other site 682795000881 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 682795000882 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 682795000883 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 682795000884 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 682795000885 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 682795000886 active site 682795000887 catalytic nucleophile [active] 682795000888 dimer interface [polypeptide binding]; other site 682795000889 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 682795000890 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 682795000891 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 682795000892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795000893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795000894 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 682795000895 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 682795000896 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 682795000897 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 682795000898 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 682795000899 hypothetical protein; Provisional; Region: PRK11239 682795000900 Protein of unknown function, DUF480; Region: DUF480; pfam04337 682795000901 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 682795000902 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 682795000903 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 682795000904 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 682795000905 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 682795000906 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 682795000907 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 682795000908 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 682795000909 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 682795000910 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 682795000911 active site 682795000912 catalytic site [active] 682795000913 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795000914 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 682795000915 Protein export membrane protein; Region: SecD_SecF; cl14618 682795000916 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 682795000917 Protein export membrane protein; Region: SecD_SecF; cl14618 682795000918 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795000919 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795000920 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795000921 hypothetical protein; Validated; Region: PRK08238 682795000922 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 682795000923 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 682795000924 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 682795000925 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 682795000926 dimer interface [polypeptide binding]; other site 682795000927 motif 1; other site 682795000928 active site 682795000929 motif 2; other site 682795000930 motif 3; other site 682795000931 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 682795000932 four helix bundle protein; Region: TIGR02436 682795000933 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 682795000934 B3/4 domain; Region: B3_4; pfam03483 682795000935 tRNA synthetase B5 domain; Region: B5; smart00874 682795000936 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 682795000937 dimer interface [polypeptide binding]; other site 682795000938 motif 1; other site 682795000939 motif 3; other site 682795000940 motif 2; other site 682795000941 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 682795000942 Cell division protein ZapA; Region: ZapA; cl01146 682795000943 type III secretion protein GogB; Provisional; Region: PRK15386 682795000944 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 682795000945 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795000946 catalytic residues [active] 682795000947 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 682795000948 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 682795000949 RNA binding surface [nucleotide binding]; other site 682795000950 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 682795000951 active site 682795000952 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795000953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795000954 metal ion-dependent adhesion site (MIDAS); other site 682795000955 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 682795000956 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 682795000957 B1 nucleotide binding pocket [chemical binding]; other site 682795000958 B2 nucleotide binding pocket [chemical binding]; other site 682795000959 CAS motifs; other site 682795000960 active site 682795000961 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 682795000962 Part of AAA domain; Region: AAA_19; pfam13245 682795000963 AAA domain; Region: AAA_14; pfam13173 682795000964 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 682795000965 Family description; Region: UvrD_C_2; pfam13538 682795000966 amino acid transporter; Region: 2A0306; TIGR00909 682795000967 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 682795000968 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 682795000969 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 682795000970 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 682795000971 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 682795000972 adenosine deaminase; Provisional; Region: PRK09358 682795000973 active site 682795000974 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 682795000975 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 682795000976 CGNR zinc finger; Region: zf-CGNR; pfam11706 682795000977 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 682795000978 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795000979 hypothetical protein; Provisional; Region: PRK10621 682795000980 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 682795000981 Protein of unknown function (DUF971); Region: DUF971; pfam06155 682795000982 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 682795000983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 682795000984 Walker A/P-loop; other site 682795000985 ATP binding site [chemical binding]; other site 682795000986 Q-loop/lid; other site 682795000987 ABC transporter signature motif; other site 682795000988 Walker B; other site 682795000989 D-loop; other site 682795000990 H-loop/switch region; other site 682795000991 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 682795000992 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 682795000993 SnoaL-like domain; Region: SnoaL_3; pfam13474 682795000994 oxidoreductase; Provisional; Region: PRK06128 682795000995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795000996 NAD(P) binding site [chemical binding]; other site 682795000997 active site 682795000998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 682795000999 RNA binding surface [nucleotide binding]; other site 682795001000 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795001001 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795001002 lipoyl synthase; Provisional; Region: PRK05481 682795001003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795001004 FeS/SAM binding site; other site 682795001005 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 682795001006 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 682795001007 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 682795001008 SurA N-terminal domain; Region: SurA_N_3; cl07813 682795001009 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 682795001010 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 682795001011 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 682795001012 ligand binding site [chemical binding]; other site 682795001013 NAD binding site [chemical binding]; other site 682795001014 dimerization interface [polypeptide binding]; other site 682795001015 catalytic site [active] 682795001016 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 682795001017 putative L-serine binding site [chemical binding]; other site 682795001018 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 682795001019 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 682795001020 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 682795001021 active site 682795001022 tetramer interface; other site 682795001023 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 682795001024 Condensation domain; Region: Condensation; pfam00668 682795001025 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 682795001026 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 682795001027 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795001028 ATP binding site [chemical binding]; other site 682795001029 putative Mg++ binding site [ion binding]; other site 682795001030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 682795001031 nucleotide binding region [chemical binding]; other site 682795001032 ATP-binding site [chemical binding]; other site 682795001033 TRCF domain; Region: TRCF; pfam03461 682795001034 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 682795001035 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 682795001036 GatB domain; Region: GatB_Yqey; smart00845 682795001037 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 682795001038 Peptidase M15; Region: Peptidase_M15_3; cl01194 682795001039 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 682795001040 RDD family; Region: RDD; pfam06271 682795001041 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 682795001042 Organic solvent tolerance protein; Region: OstA_C; pfam04453 682795001043 Thioredoxin; Region: Thioredoxin_4; cl17273 682795001044 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 682795001045 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795001046 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 682795001047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795001048 FeS/SAM binding site; other site 682795001049 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 682795001050 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 682795001051 MarR family; Region: MarR_2; pfam12802 682795001052 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 682795001053 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795001054 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 682795001055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795001056 Walker A motif; other site 682795001057 ATP binding site [chemical binding]; other site 682795001058 Walker B motif; other site 682795001059 arginine finger; other site 682795001060 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 682795001061 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 682795001062 Helix-turn-helix domain; Region: HTH_38; pfam13936 682795001063 Integrase core domain; Region: rve; pfam00665 682795001064 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 682795001065 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 682795001066 putative active site [active] 682795001067 H+ Antiporter protein; Region: 2A0121; TIGR00900 682795001068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795001069 putative substrate translocation pore; other site 682795001070 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 682795001071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 682795001072 substrate binding pocket [chemical binding]; other site 682795001073 catalytic triad [active] 682795001074 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 682795001075 Putative esterase; Region: Esterase; pfam00756 682795001076 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 682795001077 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 682795001078 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 682795001079 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 682795001080 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795001081 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795001082 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 682795001083 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 682795001084 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 682795001085 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 682795001086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 682795001087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 682795001088 ABC transporter; Region: ABC_tran_2; pfam12848 682795001089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 682795001090 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 682795001091 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 682795001092 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 682795001093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795001094 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 682795001095 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 682795001096 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 682795001097 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 682795001098 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 682795001099 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 682795001100 RNA/DNA hybrid binding site [nucleotide binding]; other site 682795001101 active site 682795001102 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 682795001103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795001104 active site 682795001105 metal binding site [ion binding]; metal-binding site 682795001106 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 682795001107 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795001108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795001109 DNA binding residues [nucleotide binding] 682795001110 Putative zinc-finger; Region: zf-HC2; pfam13490 682795001111 HEAT repeats; Region: HEAT_2; pfam13646 682795001112 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 682795001113 protein binding site [polypeptide binding]; other site 682795001114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 682795001115 protein binding site [polypeptide binding]; other site 682795001116 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 682795001117 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 682795001118 catalytic loop [active] 682795001119 iron binding site [ion binding]; other site 682795001120 chaperone protein HscA; Provisional; Region: hscA; PRK05183 682795001121 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 682795001122 nucleotide binding site [chemical binding]; other site 682795001123 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 682795001124 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 682795001125 NAD(P) binding site [chemical binding]; other site 682795001126 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 682795001127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795001128 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 682795001129 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 682795001130 co-chaperone HscB; Provisional; Region: hscB; PRK05014 682795001131 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 682795001132 HSP70 interaction site [polypeptide binding]; other site 682795001133 Helix-turn-helix domain; Region: HTH_28; pfam13518 682795001134 Winged helix-turn helix; Region: HTH_29; pfam13551 682795001135 Homeodomain-like domain; Region: HTH_32; pfam13565 682795001136 putative transposase OrfB; Reviewed; Region: PHA02517 682795001137 Integrase core domain; Region: rve; pfam00665 682795001138 Integrase core domain; Region: rve_3; pfam13683 682795001139 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 682795001140 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 682795001141 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 682795001142 trimerization site [polypeptide binding]; other site 682795001143 active site 682795001144 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 682795001145 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 682795001146 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795001147 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795001148 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795001149 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795001150 cysteine desulfurase; Provisional; Region: PRK14012 682795001151 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 682795001152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795001153 catalytic residue [active] 682795001154 Predicted transcriptional regulator [Transcription]; Region: COG1959 682795001155 Transcriptional regulator; Region: Rrf2; pfam02082 682795001156 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 682795001157 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 682795001158 methionine sulfoxide reductase B; Provisional; Region: PRK00222 682795001159 SelR domain; Region: SelR; pfam01641 682795001160 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795001161 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795001162 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 682795001163 homotrimer interaction site [polypeptide binding]; other site 682795001164 putative active site [active] 682795001165 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 682795001166 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 682795001167 Glucose inhibited division protein A; Region: GIDA; pfam01134 682795001168 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 682795001169 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 682795001170 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 682795001171 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 682795001172 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 682795001173 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 682795001174 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 682795001175 putative active site [active] 682795001176 Phospholipid methyltransferase; Region: PEMT; cl17370 682795001177 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 682795001178 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 682795001179 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 682795001180 Ligand Binding Site [chemical binding]; other site 682795001181 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795001182 TPR repeat; Region: TPR_11; pfam13414 682795001183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795001184 binding surface 682795001185 TPR motif; other site 682795001186 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 682795001187 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 682795001188 dimer interface [polypeptide binding]; other site 682795001189 putative functional site; other site 682795001190 putative MPT binding site; other site 682795001191 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 682795001192 trimer interface [polypeptide binding]; other site 682795001193 dimer interface [polypeptide binding]; other site 682795001194 putative active site [active] 682795001195 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 682795001196 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 682795001197 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 682795001198 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 682795001199 CCC1; Region: CCC1; cd02435 682795001200 Predicted transcriptional regulators [Transcription]; Region: COG1733 682795001201 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 682795001202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795001203 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 682795001204 NAD(P) binding site [chemical binding]; other site 682795001205 active site 682795001206 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 682795001207 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 682795001208 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 682795001209 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 682795001210 RNA binding surface [nucleotide binding]; other site 682795001211 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 682795001212 active site 682795001213 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795001214 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 682795001215 active site 682795001216 catalytic triad [active] 682795001217 oxyanion hole [active] 682795001218 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 682795001219 Protein of unknown function, DUF417; Region: DUF417; cl01162 682795001220 Cupin; Region: Cupin_6; pfam12852 682795001221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795001222 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795001223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795001224 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795001225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795001226 active site 682795001227 phosphorylation site [posttranslational modification] 682795001228 intermolecular recognition site; other site 682795001229 dimerization interface [polypeptide binding]; other site 682795001230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795001231 DNA binding site [nucleotide binding] 682795001232 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 682795001233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795001234 dimer interface [polypeptide binding]; other site 682795001235 phosphorylation site [posttranslational modification] 682795001236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795001237 ATP binding site [chemical binding]; other site 682795001238 Mg2+ binding site [ion binding]; other site 682795001239 G-X-G motif; other site 682795001240 multicopper oxidase; Provisional; Region: PRK10965 682795001241 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 682795001242 Multicopper oxidase; Region: Cu-oxidase; pfam00394 682795001243 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 682795001244 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795001245 PBP superfamily domain; Region: PBP_like_2; cl17296 682795001246 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 682795001247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795001248 dimer interface [polypeptide binding]; other site 682795001249 conserved gate region; other site 682795001250 putative PBP binding loops; other site 682795001251 ABC-ATPase subunit interface; other site 682795001252 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 682795001253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795001254 dimer interface [polypeptide binding]; other site 682795001255 conserved gate region; other site 682795001256 putative PBP binding loops; other site 682795001257 ABC-ATPase subunit interface; other site 682795001258 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 682795001259 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 682795001260 Walker A/P-loop; other site 682795001261 ATP binding site [chemical binding]; other site 682795001262 Q-loop/lid; other site 682795001263 ABC transporter signature motif; other site 682795001264 Walker B; other site 682795001265 D-loop; other site 682795001266 H-loop/switch region; other site 682795001267 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 682795001268 PhoU domain; Region: PhoU; pfam01895 682795001269 PhoU domain; Region: PhoU; pfam01895 682795001270 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 682795001271 active site 682795001272 FMN binding site [chemical binding]; other site 682795001273 substrate binding site [chemical binding]; other site 682795001274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 682795001275 active site 682795001276 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 682795001277 active site 682795001278 dimer interface [polypeptide binding]; other site 682795001279 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 682795001280 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795001281 active site 682795001282 aspartate carbamoyltransferase; Region: PLN02527 682795001283 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 682795001284 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 682795001285 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 682795001286 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 682795001287 dimerization interface [polypeptide binding]; other site 682795001288 DPS ferroxidase diiron center [ion binding]; other site 682795001289 ion pore; other site 682795001290 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795001291 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 682795001292 Na binding site [ion binding]; other site 682795001293 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795001294 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 682795001295 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 682795001296 substrate binding site [chemical binding]; other site 682795001297 oxyanion hole (OAH) forming residues; other site 682795001298 trimer interface [polypeptide binding]; other site 682795001299 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 682795001300 homopentamer interface [polypeptide binding]; other site 682795001301 active site 682795001302 transcription antitermination factor NusB; Region: nusB; TIGR01951 682795001303 putative RNA binding site [nucleotide binding]; other site 682795001304 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 682795001305 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795001306 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795001307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795001308 Coenzyme A binding pocket [chemical binding]; other site 682795001309 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 682795001310 S17 interaction site [polypeptide binding]; other site 682795001311 S8 interaction site; other site 682795001312 16S rRNA interaction site [nucleotide binding]; other site 682795001313 streptomycin interaction site [chemical binding]; other site 682795001314 23S rRNA interaction site [nucleotide binding]; other site 682795001315 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 682795001316 30S ribosomal protein S7; Validated; Region: PRK05302 682795001317 elongation factor G; Reviewed; Region: PRK00007 682795001318 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 682795001319 G1 box; other site 682795001320 putative GEF interaction site [polypeptide binding]; other site 682795001321 GTP/Mg2+ binding site [chemical binding]; other site 682795001322 Switch I region; other site 682795001323 G2 box; other site 682795001324 G3 box; other site 682795001325 Switch II region; other site 682795001326 G4 box; other site 682795001327 G5 box; other site 682795001328 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 682795001329 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 682795001330 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 682795001331 elongation factor Tu; Reviewed; Region: PRK00049 682795001332 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 682795001333 G1 box; other site 682795001334 GEF interaction site [polypeptide binding]; other site 682795001335 GTP/Mg2+ binding site [chemical binding]; other site 682795001336 Switch I region; other site 682795001337 G2 box; other site 682795001338 G3 box; other site 682795001339 Switch II region; other site 682795001340 G4 box; other site 682795001341 G5 box; other site 682795001342 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 682795001343 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 682795001344 Antibiotic Binding Site [chemical binding]; other site 682795001345 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 682795001346 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 682795001347 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 682795001348 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 682795001349 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 682795001350 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 682795001351 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 682795001352 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 682795001353 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 682795001354 putative translocon binding site; other site 682795001355 protein-rRNA interface [nucleotide binding]; other site 682795001356 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 682795001357 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 682795001358 G-X-X-G motif; other site 682795001359 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 682795001360 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 682795001361 23S rRNA interface [nucleotide binding]; other site 682795001362 5S rRNA interface [nucleotide binding]; other site 682795001363 putative antibiotic binding site [chemical binding]; other site 682795001364 L25 interface [polypeptide binding]; other site 682795001365 L27 interface [polypeptide binding]; other site 682795001366 50S ribosomal protein L29; Reviewed; Region: PRK00306 682795001367 putative translocon interaction site; other site 682795001368 signal recognition particle (SRP54) interaction site; other site 682795001369 L23 interface [polypeptide binding]; other site 682795001370 trigger factor interaction site; other site 682795001371 23S rRNA interface [nucleotide binding]; other site 682795001372 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 682795001373 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 682795001374 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 682795001375 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 682795001376 RNA binding site [nucleotide binding]; other site 682795001377 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 682795001378 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 682795001379 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 682795001380 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 682795001381 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 682795001382 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 682795001383 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 682795001384 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 682795001385 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 682795001386 23S rRNA interface [nucleotide binding]; other site 682795001387 L21e interface [polypeptide binding]; other site 682795001388 5S rRNA interface [nucleotide binding]; other site 682795001389 L27 interface [polypeptide binding]; other site 682795001390 L5 interface [polypeptide binding]; other site 682795001391 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 682795001392 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 682795001393 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 682795001394 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 682795001395 23S rRNA binding site [nucleotide binding]; other site 682795001396 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 682795001397 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 682795001398 SecY translocase; Region: SecY; pfam00344 682795001399 adenylate kinase; Reviewed; Region: adk; PRK00279 682795001400 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 682795001401 AMP-binding site [chemical binding]; other site 682795001402 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 682795001403 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 682795001404 active site 682795001405 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 682795001406 active site 682795001407 substrate-binding site [chemical binding]; other site 682795001408 metal-binding site [ion binding] 682795001409 GTP binding site [chemical binding]; other site 682795001410 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 682795001411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795001412 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 682795001413 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 682795001414 homodimer interface [polypeptide binding]; other site 682795001415 substrate-cofactor binding pocket; other site 682795001416 catalytic residue [active] 682795001417 MarC family integral membrane protein; Region: MarC; pfam01914 682795001418 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 682795001419 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 682795001420 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795001421 Epoxide hydrolase N terminus; Region: EHN; pfam06441 682795001422 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795001423 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 682795001424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795001425 putative active site [active] 682795001426 heme pocket [chemical binding]; other site 682795001427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795001428 putative active site [active] 682795001429 heme pocket [chemical binding]; other site 682795001430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795001431 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 682795001432 Walker A motif; other site 682795001433 ATP binding site [chemical binding]; other site 682795001434 Walker B motif; other site 682795001435 arginine finger; other site 682795001436 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 682795001437 Uncharacterized conserved protein [Function unknown]; Region: COG3595 682795001438 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 682795001439 Putative zinc-finger; Region: zf-HC2; pfam13490 682795001440 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 682795001441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795001442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795001443 DNA binding residues [nucleotide binding] 682795001444 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 682795001445 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 682795001446 E-class dimer interface [polypeptide binding]; other site 682795001447 P-class dimer interface [polypeptide binding]; other site 682795001448 active site 682795001449 Cu2+ binding site [ion binding]; other site 682795001450 Zn2+ binding site [ion binding]; other site 682795001451 thymidine kinase; Provisional; Region: PRK04296 682795001452 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795001453 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 682795001454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 682795001455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795001456 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795001457 active site 682795001458 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 682795001459 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 682795001460 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 682795001461 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 682795001462 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 682795001463 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 682795001464 CoA-ligase; Region: Ligase_CoA; pfam00549 682795001465 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 682795001466 CoA binding domain; Region: CoA_binding; smart00881 682795001467 CoA-ligase; Region: Ligase_CoA; pfam00549 682795001468 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 682795001469 active site 682795001470 multimer interface [polypeptide binding]; other site 682795001471 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 682795001472 active site 682795001473 catalytic triad [active] 682795001474 oxyanion hole [active] 682795001475 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 682795001476 active site 682795001477 catalytic residues [active] 682795001478 fumarylacetoacetase; Region: PLN02856 682795001479 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 682795001480 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 682795001481 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795001482 active site 682795001483 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795001484 catalytic tetrad [active] 682795001485 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 682795001486 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 682795001487 dimer interface [polypeptide binding]; other site 682795001488 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 682795001489 active site 682795001490 Fe binding site [ion binding]; other site 682795001491 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 682795001492 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 682795001493 NADP binding site [chemical binding]; other site 682795001494 active site 682795001495 steroid binding site; other site 682795001496 short chain dehydrogenase; Provisional; Region: PRK12937 682795001497 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 682795001498 NADP binding site [chemical binding]; other site 682795001499 homodimer interface [polypeptide binding]; other site 682795001500 active site 682795001501 substrate binding site [chemical binding]; other site 682795001502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795001503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795001504 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 682795001505 substrate binding pocket [chemical binding]; other site 682795001506 dimerization interface [polypeptide binding]; other site 682795001507 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 682795001508 dimer interface [polypeptide binding]; other site 682795001509 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 682795001510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795001511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795001512 DNA binding residues [nucleotide binding] 682795001513 O-Antigen ligase; Region: Wzy_C; pfam04932 682795001514 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 682795001515 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 682795001516 Right handed beta helix region; Region: Beta_helix; pfam13229 682795001517 Domain of unknown function DUF20; Region: UPF0118; pfam01594 682795001518 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 682795001519 shikimate kinase; Reviewed; Region: aroK; PRK00131 682795001520 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 682795001521 ADP binding site [chemical binding]; other site 682795001522 magnesium binding site [ion binding]; other site 682795001523 putative shikimate binding site; other site 682795001524 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 682795001525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795001526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795001527 DNA binding residues [nucleotide binding] 682795001528 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 682795001529 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 682795001530 ATP binding site [chemical binding]; other site 682795001531 substrate interface [chemical binding]; other site 682795001532 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795001533 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795001534 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795001535 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795001536 Surface antigen; Region: Bac_surface_Ag; pfam01103 682795001537 SurA N-terminal domain; Region: SurA_N; pfam09312 682795001538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 682795001539 Family of unknown function (DUF490); Region: DUF490; pfam04357 682795001540 BON domain; Region: BON; pfam04972 682795001541 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 682795001542 BON domain; Region: BON; pfam04972 682795001543 BON domain; Region: BON; pfam04972 682795001544 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 682795001545 UbiA prenyltransferase family; Region: UbiA; pfam01040 682795001546 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 682795001547 CsbD-like; Region: CsbD; pfam05532 682795001548 prephenate dehydratase; Provisional; Region: PRK11898 682795001549 Prephenate dehydratase; Region: PDT; pfam00800 682795001550 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 682795001551 putative L-Phe binding site [chemical binding]; other site 682795001552 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 682795001553 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 682795001554 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 682795001555 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 682795001556 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 682795001557 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 682795001558 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 682795001559 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 682795001560 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 682795001561 putative active site [active] 682795001562 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 682795001563 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 682795001564 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 682795001565 Walker A motif; other site 682795001566 ATP binding site [chemical binding]; other site 682795001567 Walker B motif; other site 682795001568 Competence protein A; Region: Competence_A; pfam11104 682795001569 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 682795001570 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 682795001571 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 682795001572 active site 682795001573 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795001574 peptidase domain interface [polypeptide binding]; other site 682795001575 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795001576 active site 682795001577 catalytic triad [active] 682795001578 calcium binding site [ion binding]; other site 682795001579 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795001580 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 682795001581 RHS Repeat; Region: RHS_repeat; pfam05593 682795001582 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 682795001583 Predicted integral membrane protein [Function unknown]; Region: COG5650 682795001584 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 682795001585 translation initiation factor IF-2; Region: IF-2; TIGR00487 682795001586 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 682795001587 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 682795001588 G1 box; other site 682795001589 putative GEF interaction site [polypeptide binding]; other site 682795001590 GTP/Mg2+ binding site [chemical binding]; other site 682795001591 Switch I region; other site 682795001592 G2 box; other site 682795001593 G3 box; other site 682795001594 Switch II region; other site 682795001595 G4 box; other site 682795001596 G5 box; other site 682795001597 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 682795001598 Translation-initiation factor 2; Region: IF-2; pfam11987 682795001599 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 682795001600 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 682795001601 NusA N-terminal domain; Region: NusA_N; pfam08529 682795001602 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 682795001603 RNA binding site [nucleotide binding]; other site 682795001604 homodimer interface [polypeptide binding]; other site 682795001605 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 682795001606 G-X-X-G motif; other site 682795001607 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 682795001608 G-X-X-G motif; other site 682795001609 ribosome maturation protein RimP; Reviewed; Region: PRK00092 682795001610 Sm and related proteins; Region: Sm_like; cl00259 682795001611 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 682795001612 putative oligomer interface [polypeptide binding]; other site 682795001613 putative RNA binding site [nucleotide binding]; other site 682795001614 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 682795001615 active site 682795001616 NTP binding site [chemical binding]; other site 682795001617 metal binding triad [ion binding]; metal-binding site 682795001618 antibiotic binding site [chemical binding]; other site 682795001619 HEPN domain; Region: HEPN; pfam05168 682795001620 Protein of unknown function (DUF503); Region: DUF503; cl00669 682795001621 Ribosome-binding factor A; Region: RBFA; pfam02033 682795001622 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 682795001623 DHH family; Region: DHH; pfam01368 682795001624 DHHA1 domain; Region: DHHA1; pfam02272 682795001625 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 682795001626 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 682795001627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795001628 Coenzyme A binding pocket [chemical binding]; other site 682795001629 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 682795001630 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 682795001631 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 682795001632 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 682795001633 active site 682795001634 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795001635 Amidase; Region: Amidase; cl11426 682795001636 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 682795001637 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 682795001638 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 682795001639 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 682795001640 circadian clock protein KaiC; Reviewed; Region: PRK09302 682795001641 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 682795001642 Walker A motif; other site 682795001643 ATP binding site [chemical binding]; other site 682795001644 Walker B motif; other site 682795001645 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 682795001646 Walker A motif; other site 682795001647 ATP binding site [chemical binding]; other site 682795001648 Walker B motif; other site 682795001649 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 682795001650 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 682795001651 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795001652 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 682795001653 ribonuclease PH; Reviewed; Region: rph; PRK00173 682795001654 Ribonuclease PH; Region: RNase_PH_bact; cd11362 682795001655 hexamer interface [polypeptide binding]; other site 682795001656 active site 682795001657 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 682795001658 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 682795001659 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 682795001660 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795001661 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 682795001662 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 682795001663 Zn binding site [ion binding]; other site 682795001664 allantoate amidohydrolase; Reviewed; Region: PRK09290 682795001665 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 682795001666 active site 682795001667 metal binding site [ion binding]; metal-binding site 682795001668 dimer interface [polypeptide binding]; other site 682795001669 hypothetical protein; Provisional; Region: PRK11171 682795001670 Cupin domain; Region: Cupin_2; cl17218 682795001671 allantoate amidohydrolase; Reviewed; Region: PRK09290 682795001672 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 682795001673 active site 682795001674 metal binding site [ion binding]; metal-binding site 682795001675 dimer interface [polypeptide binding]; other site 682795001676 urate oxidase; Region: urate_oxi; TIGR03383 682795001677 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 682795001678 active site 682795001679 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 682795001680 active site 682795001681 homotetramer interface [polypeptide binding]; other site 682795001682 putative OHCU decarboxylase; Provisional; Region: PRK13798 682795001683 allantoinase; Region: allantoinase; TIGR03178 682795001684 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 682795001685 active site 682795001686 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 682795001687 nucleoside/Zn binding site; other site 682795001688 dimer interface [polypeptide binding]; other site 682795001689 catalytic motif [active] 682795001690 homoserine dehydrogenase; Provisional; Region: PRK06349 682795001691 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 682795001692 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 682795001693 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 682795001694 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 682795001695 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 682795001696 ATP binding site [chemical binding]; other site 682795001697 substrate interface [chemical binding]; other site 682795001698 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 682795001699 active site residue [active] 682795001700 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 682795001701 MoaE interaction surface [polypeptide binding]; other site 682795001702 MoeB interaction surface [polypeptide binding]; other site 682795001703 thiocarboxylated glycine; other site 682795001704 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 682795001705 MPN+ (JAMM) motif; other site 682795001706 Zinc-binding site [ion binding]; other site 682795001707 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 682795001708 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 682795001709 dimer interface [polypeptide binding]; other site 682795001710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795001711 catalytic residue [active] 682795001712 Transposase domain (DUF772); Region: DUF772; pfam05598 682795001713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 682795001714 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 682795001715 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 682795001716 Predicted methyltransferases [General function prediction only]; Region: COG0313 682795001717 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 682795001718 putative SAM binding site [chemical binding]; other site 682795001719 putative homodimer interface [polypeptide binding]; other site 682795001720 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 682795001721 active site 682795001722 putative substrate binding region [chemical binding]; other site 682795001723 FOG: CBS domain [General function prediction only]; Region: COG0517 682795001724 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 682795001725 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 682795001726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 682795001727 thiamine monophosphate kinase; Provisional; Region: PRK05731 682795001728 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 682795001729 ATP binding site [chemical binding]; other site 682795001730 dimerization interface [polypeptide binding]; other site 682795001731 Transposase domain (DUF772); Region: DUF772; pfam05598 682795001732 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 682795001733 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 682795001734 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795001735 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 682795001736 active site 682795001737 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 682795001738 Peptidase family M23; Region: Peptidase_M23; pfam01551 682795001739 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 682795001740 AIR carboxylase; Region: AIRC; smart01001 682795001741 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 682795001742 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 682795001743 Ligand Binding Site [chemical binding]; other site 682795001744 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 682795001745 Protein of unknown function DUF72; Region: DUF72; cl00777 682795001746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 682795001747 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 682795001748 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 682795001749 phage shock protein A; Region: phageshock_pspA; TIGR02977 682795001750 short chain dehydrogenase; Provisional; Region: PRK06500 682795001751 classical (c) SDRs; Region: SDR_c; cd05233 682795001752 NAD(P) binding site [chemical binding]; other site 682795001753 active site 682795001754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795001755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795001756 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 682795001757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795001758 active site 682795001759 phosphorylation site [posttranslational modification] 682795001760 intermolecular recognition site; other site 682795001761 dimerization interface [polypeptide binding]; other site 682795001762 LytTr DNA-binding domain; Region: LytTR; smart00850 682795001763 Histidine kinase; Region: His_kinase; pfam06580 682795001764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795001765 ATP binding site [chemical binding]; other site 682795001766 Mg2+ binding site [ion binding]; other site 682795001767 G-X-G motif; other site 682795001768 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 682795001769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795001770 binding surface 682795001771 TPR motif; other site 682795001772 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 682795001773 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 682795001774 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 682795001775 elongation factor Tu; Reviewed; Region: PRK00049 682795001776 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 682795001777 G1 box; other site 682795001778 GEF interaction site [polypeptide binding]; other site 682795001779 GTP/Mg2+ binding site [chemical binding]; other site 682795001780 Switch I region; other site 682795001781 G2 box; other site 682795001782 G3 box; other site 682795001783 Switch II region; other site 682795001784 G4 box; other site 682795001785 G5 box; other site 682795001786 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 682795001787 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 682795001788 Antibiotic Binding Site [chemical binding]; other site 682795001789 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 682795001790 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 682795001791 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 682795001792 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 682795001793 putative homodimer interface [polypeptide binding]; other site 682795001794 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 682795001795 heterodimer interface [polypeptide binding]; other site 682795001796 homodimer interface [polypeptide binding]; other site 682795001797 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 682795001798 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 682795001799 23S rRNA interface [nucleotide binding]; other site 682795001800 L7/L12 interface [polypeptide binding]; other site 682795001801 putative thiostrepton binding site; other site 682795001802 L25 interface [polypeptide binding]; other site 682795001803 TPR repeat; Region: TPR_11; pfam13414 682795001804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795001805 binding surface 682795001806 TPR motif; other site 682795001807 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 682795001808 Sulfatase; Region: Sulfatase; pfam00884 682795001809 Laminin G domain; Region: LamG; smart00282 682795001810 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 682795001811 catalytic motif [active] 682795001812 Catalytic residue [active] 682795001813 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 682795001814 inhibitor binding site; inhibition site 682795001815 catalytic motif [active] 682795001816 Catalytic residue [active] 682795001817 Active site flap [active] 682795001818 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 682795001819 protein binding site [polypeptide binding]; other site 682795001820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 682795001821 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 682795001822 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 682795001823 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 682795001824 substrate binding site [chemical binding]; other site 682795001825 dimer interface [polypeptide binding]; other site 682795001826 ATP binding site [chemical binding]; other site 682795001827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795001828 NAD(P) binding site [chemical binding]; other site 682795001829 short chain dehydrogenase; Provisional; Region: PRK07041 682795001830 active site 682795001831 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795001832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795001833 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 682795001834 substrate binding pocket [chemical binding]; other site 682795001835 dimerization interface [polypeptide binding]; other site 682795001836 Radical SAM superfamily; Region: Radical_SAM; pfam04055 682795001837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795001838 FeS/SAM binding site; other site 682795001839 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 682795001840 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795001841 Domain of unknown function (DUF756); Region: DUF756; pfam05506 682795001842 Domain of unknown function (DUF756); Region: DUF756; pfam05506 682795001843 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 682795001844 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 682795001845 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 682795001846 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 682795001847 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 682795001848 putative acyl-acceptor binding pocket; other site 682795001849 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 682795001850 mRNA/rRNA interface [nucleotide binding]; other site 682795001851 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 682795001852 23S rRNA interface [nucleotide binding]; other site 682795001853 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 682795001854 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 682795001855 L11 interface [polypeptide binding]; other site 682795001856 putative EF-Tu interaction site [polypeptide binding]; other site 682795001857 putative EF-G interaction site [polypeptide binding]; other site 682795001858 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 682795001859 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 682795001860 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 682795001861 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 682795001862 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 682795001863 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 682795001864 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 682795001865 RPB3 interaction site [polypeptide binding]; other site 682795001866 RPB1 interaction site [polypeptide binding]; other site 682795001867 RPB11 interaction site [polypeptide binding]; other site 682795001868 RPB10 interaction site [polypeptide binding]; other site 682795001869 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 682795001870 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 682795001871 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 682795001872 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 682795001873 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 682795001874 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 682795001875 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 682795001876 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 682795001877 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 682795001878 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 682795001879 DNA binding site [nucleotide binding] 682795001880 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 682795001881 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 682795001882 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 682795001883 putative active site [active] 682795001884 putative NTP binding site [chemical binding]; other site 682795001885 putative nucleic acid binding site [nucleotide binding]; other site 682795001886 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 682795001887 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 682795001888 putative active site [active] 682795001889 Transposase IS200 like; Region: Y1_Tnp; cl00848 682795001890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795001891 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795001892 NAD(P) binding site [chemical binding]; other site 682795001893 active site 682795001894 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 682795001895 active site 682795001896 Zn binding site [ion binding]; other site 682795001897 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 682795001898 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795001899 putative metal binding site [ion binding]; other site 682795001900 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 682795001901 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 682795001902 generic binding surface II; other site 682795001903 generic binding surface I; other site 682795001904 Ion channel; Region: Ion_trans_2; pfam07885 682795001905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 682795001906 binding surface 682795001907 TPR motif; other site 682795001908 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 682795001909 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 682795001910 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 682795001911 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 682795001912 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 682795001913 NAD(P) binding site [chemical binding]; other site 682795001914 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 682795001915 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 682795001916 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 682795001917 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 682795001918 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 682795001919 glutamine binding [chemical binding]; other site 682795001920 catalytic triad [active] 682795001921 translation elongation factor P; Region: efp; TIGR00038 682795001922 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 682795001923 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 682795001924 RNA binding site [nucleotide binding]; other site 682795001925 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 682795001926 RNA binding site [nucleotide binding]; other site 682795001927 Acylphosphatase; Region: Acylphosphatase; pfam00708 682795001928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 682795001929 active site 682795001930 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 682795001931 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795001932 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 682795001933 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 682795001934 putative NAD(P) binding site [chemical binding]; other site 682795001935 putative substrate binding site [chemical binding]; other site 682795001936 catalytic Zn binding site [ion binding]; other site 682795001937 structural Zn binding site [ion binding]; other site 682795001938 dimer interface [polypeptide binding]; other site 682795001939 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 682795001940 Protein of unknown function, DUF481; Region: DUF481; cl01213 682795001941 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338 682795001942 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 682795001943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795001944 NAD(P) binding site [chemical binding]; other site 682795001945 active site 682795001946 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 682795001947 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 682795001948 ligand binding site [chemical binding]; other site 682795001949 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 682795001950 Fumarase C-terminus; Region: Fumerase_C; pfam05683 682795001951 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 682795001952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795001953 Walker A/P-loop; other site 682795001954 ATP binding site [chemical binding]; other site 682795001955 Q-loop/lid; other site 682795001956 ABC transporter signature motif; other site 682795001957 Walker B; other site 682795001958 D-loop; other site 682795001959 H-loop/switch region; other site 682795001960 ABC-2 type transporter; Region: ABC2_membrane; cl17235 682795001961 Uncharacterized conserved protein [Function unknown]; Region: COG3391 682795001962 NHL repeat; Region: NHL; pfam01436 682795001963 NHL repeat; Region: NHL; pfam01436 682795001964 NHL repeat; Region: NHL; pfam01436 682795001965 NHL repeat; Region: NHL; pfam01436 682795001966 NHL repeat; Region: NHL; pfam01436 682795001967 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 682795001968 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 682795001969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795001970 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 682795001971 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795001972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795001973 TPR motif; other site 682795001974 binding surface 682795001975 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 682795001976 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 682795001977 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 682795001978 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 682795001979 Alginate lyase; Region: Alginate_lyase; pfam05426 682795001980 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 682795001981 Predicted membrane protein [Function unknown]; Region: COG4270 682795001982 Bacitracin resistance protein BacA; Region: BacA; pfam02673 682795001983 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 682795001984 putative transporter; Provisional; Region: PRK10504 682795001985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795001986 putative substrate translocation pore; other site 682795001987 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 682795001988 CheB methylesterase; Region: CheB_methylest; pfam01339 682795001989 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 682795001990 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 682795001991 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 682795001992 PAS domain; Region: PAS_10; pfam13596 682795001993 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 682795001994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795001995 dimer interface [polypeptide binding]; other site 682795001996 phosphorylation site [posttranslational modification] 682795001997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795001998 ATP binding site [chemical binding]; other site 682795001999 Mg2+ binding site [ion binding]; other site 682795002000 G-X-G motif; other site 682795002001 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 682795002002 DNA binding residues [nucleotide binding] 682795002003 TOBE domain; Region: TOBE; cl01440 682795002004 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002005 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 682795002006 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 682795002007 N-terminal plug; other site 682795002008 ligand-binding site [chemical binding]; other site 682795002009 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 682795002010 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 682795002011 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002012 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795002013 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 682795002014 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795002015 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795002016 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795002017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795002018 TPR motif; other site 682795002019 TPR repeat; Region: TPR_11; pfam13414 682795002020 binding surface 682795002021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795002022 binding surface 682795002023 TPR motif; other site 682795002024 TPR repeat; Region: TPR_11; pfam13414 682795002025 TPR repeat; Region: TPR_11; pfam13414 682795002026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795002027 binding surface 682795002028 TPR motif; other site 682795002029 TPR repeat; Region: TPR_11; pfam13414 682795002030 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 682795002031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002032 putative substrate translocation pore; other site 682795002033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002034 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 682795002035 Melibiase; Region: Melibiase; pfam02065 682795002036 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795002037 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795002038 DNA binding site [nucleotide binding] 682795002039 domain linker motif; other site 682795002040 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 682795002041 ligand binding site [chemical binding]; other site 682795002042 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 682795002043 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 682795002044 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 682795002045 active site 682795002046 catalytic residues [active] 682795002047 catalytic residues [active] 682795002048 Cupin domain; Region: Cupin_2; cl17218 682795002049 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 682795002050 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 682795002051 putative NAD(P) binding site [chemical binding]; other site 682795002052 dimer interface [polypeptide binding]; other site 682795002053 short chain dehydrogenase; Provisional; Region: PRK06180 682795002054 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 682795002055 NADP binding site [chemical binding]; other site 682795002056 active site 682795002057 steroid binding site; other site 682795002058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795002059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795002060 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 682795002061 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795002062 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795002063 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 682795002064 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795002065 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 682795002066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795002067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795002068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 682795002069 dimerization interface [polypeptide binding]; other site 682795002070 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 682795002071 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 682795002072 active site 682795002073 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002074 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795002075 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795002076 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 682795002077 cyanate hydratase; Validated; Region: PRK02866 682795002078 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 682795002079 oligomer interface [polypeptide binding]; other site 682795002080 active site 682795002081 formate dehydrogenase; Provisional; Region: PRK07574 682795002082 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 682795002083 dimerization interface [polypeptide binding]; other site 682795002084 ligand binding site [chemical binding]; other site 682795002085 NAD binding site [chemical binding]; other site 682795002086 catalytic site [active] 682795002087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795002088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795002089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 682795002090 dimerization interface [polypeptide binding]; other site 682795002091 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 682795002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002093 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 682795002094 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 682795002095 substrate binding site [chemical binding]; other site 682795002096 ATP binding site [chemical binding]; other site 682795002097 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 682795002098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795002099 DNA-binding site [nucleotide binding]; DNA binding site 682795002100 UTRA domain; Region: UTRA; pfam07702 682795002101 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002102 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 682795002103 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795002104 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 682795002105 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 682795002106 substrate binding site [chemical binding]; other site 682795002107 ATP binding site [chemical binding]; other site 682795002108 Protein of unknown function, DUF481; Region: DUF481; cl01213 682795002109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795002110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795002111 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 682795002112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795002113 NAD(P) binding site [chemical binding]; other site 682795002114 active site 682795002115 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 682795002116 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795002117 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 682795002118 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795002119 Penicillinase repressor; Region: Pencillinase_R; pfam03965 682795002120 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795002121 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795002122 DNA binding site [nucleotide binding] 682795002123 domain linker motif; other site 682795002124 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795002125 ligand binding site [chemical binding]; other site 682795002126 dimerization interface [polypeptide binding]; other site 682795002127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795002128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795002129 DNA binding site [nucleotide binding] 682795002130 domain linker motif; other site 682795002131 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795002132 ligand binding site [chemical binding]; other site 682795002133 dimerization interface [polypeptide binding]; other site 682795002134 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002135 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 682795002136 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795002137 Ca binding site [ion binding]; other site 682795002138 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795002139 Ca binding site [ion binding]; other site 682795002140 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 682795002141 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795002142 Ca binding site [ion binding]; other site 682795002143 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795002144 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 682795002145 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795002146 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795002147 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 682795002148 Melibiase; Region: Melibiase; pfam02065 682795002149 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 682795002150 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 682795002151 active site 682795002152 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 682795002153 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 682795002154 ANTAR domain; Region: ANTAR; pfam03861 682795002155 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 682795002156 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 682795002157 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 682795002158 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 682795002159 Flavodoxin; Region: Flavodoxin_1; pfam00258 682795002160 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 682795002161 FAD binding pocket [chemical binding]; other site 682795002162 FAD binding motif [chemical binding]; other site 682795002163 catalytic residues [active] 682795002164 NAD binding pocket [chemical binding]; other site 682795002165 phosphate binding motif [ion binding]; other site 682795002166 beta-alpha-beta structure motif; other site 682795002167 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 682795002168 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 682795002169 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 682795002170 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 682795002171 [4Fe-4S] binding site [ion binding]; other site 682795002172 molybdopterin cofactor binding site; other site 682795002173 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 682795002174 molybdopterin cofactor binding site; other site 682795002175 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 682795002176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002177 putative substrate translocation pore; other site 682795002178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002179 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795002180 putative substrate translocation pore; other site 682795002181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795002182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795002183 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 682795002184 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795002185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795002186 NAD(P) binding site [chemical binding]; other site 682795002187 active site 682795002188 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 682795002189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795002190 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795002191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795002192 S-adenosylmethionine binding site [chemical binding]; other site 682795002193 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 682795002194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795002195 Radical SAM superfamily; Region: Radical_SAM; pfam04055 682795002196 FeS/SAM binding site; other site 682795002197 Plant calmodulin-binding domain; Region: CaM_binding; cl06741 682795002198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 682795002199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795002200 S-adenosylmethionine binding site [chemical binding]; other site 682795002201 B12 binding domain; Region: B12-binding; pfam02310 682795002202 B12 binding site [chemical binding]; other site 682795002203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795002204 Radical SAM superfamily; Region: Radical_SAM; pfam04055 682795002205 FeS/SAM binding site; other site 682795002206 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 682795002207 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 682795002208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795002209 FeS/SAM binding site; other site 682795002210 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 682795002211 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 682795002212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795002213 FeS/SAM binding site; other site 682795002214 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 682795002215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795002216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795002217 short chain dehydrogenase; Provisional; Region: PRK08219 682795002218 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 682795002219 NADP binding site [chemical binding]; other site 682795002220 substrate binding site [chemical binding]; other site 682795002221 active site 682795002222 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 682795002223 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 682795002224 NADP binding site [chemical binding]; other site 682795002225 substrate binding site [chemical binding]; other site 682795002226 active site 682795002227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795002228 S-adenosylmethionine binding site [chemical binding]; other site 682795002229 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 682795002230 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 682795002231 putative hydrophobic ligand binding site [chemical binding]; other site 682795002232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795002233 dimerization interface [polypeptide binding]; other site 682795002234 putative DNA binding site [nucleotide binding]; other site 682795002235 putative Zn2+ binding site [ion binding]; other site 682795002236 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 682795002237 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 682795002238 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 682795002239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795002240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795002241 DNA binding site [nucleotide binding] 682795002242 Predicted integral membrane protein [Function unknown]; Region: COG5616 682795002243 TPR repeat; Region: TPR_11; pfam13414 682795002244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795002245 binding surface 682795002246 TPR motif; other site 682795002247 TPR repeat; Region: TPR_11; pfam13414 682795002248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795002249 TPR motif; other site 682795002250 binding surface 682795002251 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 682795002252 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795002253 peptidase domain interface [polypeptide binding]; other site 682795002254 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795002255 active site 682795002256 catalytic triad [active] 682795002257 calcium binding site [ion binding]; other site 682795002258 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 682795002259 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 682795002260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795002261 motif II; other site 682795002262 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 682795002263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002264 putative substrate translocation pore; other site 682795002265 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 682795002266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002267 putative substrate translocation pore; other site 682795002268 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002269 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 682795002270 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 682795002271 active site 682795002272 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 682795002273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795002274 catalytic residue [active] 682795002275 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 682795002276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795002277 Serine hydrolase; Region: Ser_hydrolase; cl17834 682795002278 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 682795002279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795002280 NAD(P) binding site [chemical binding]; other site 682795002281 active site 682795002282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795002283 short chain dehydrogenase; Provisional; Region: PRK06197 682795002284 NAD(P) binding site [chemical binding]; other site 682795002285 active site 682795002286 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 682795002287 hydrophobic ligand binding site; other site 682795002288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795002289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795002290 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 682795002291 putative effector binding pocket; other site 682795002292 dimerization interface [polypeptide binding]; other site 682795002293 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 682795002294 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 682795002295 active site 682795002296 ADP/pyrophosphate binding site [chemical binding]; other site 682795002297 dimerization interface [polypeptide binding]; other site 682795002298 allosteric effector site; other site 682795002299 fructose-1,6-bisphosphate binding site; other site 682795002300 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 682795002301 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 682795002302 substrate binding site [chemical binding]; other site 682795002303 ATP binding site [chemical binding]; other site 682795002304 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 682795002305 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 682795002306 dimer interface [polypeptide binding]; other site 682795002307 active site 682795002308 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 682795002309 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 682795002310 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 682795002311 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 682795002312 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 682795002313 Amidohydrolase; Region: Amidohydro_2; pfam04909 682795002314 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 682795002315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 682795002316 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795002317 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795002318 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 682795002319 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 682795002320 dimer interface [polypeptide binding]; other site 682795002321 active site 682795002322 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 682795002323 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002324 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795002325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795002326 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795002327 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795002328 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002329 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795002330 Melibiase; Region: Melibiase; pfam02065 682795002331 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 682795002332 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 682795002333 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 682795002334 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 682795002335 active site 682795002336 trimer interface [polypeptide binding]; other site 682795002337 allosteric site; other site 682795002338 active site lid [active] 682795002339 hexamer (dimer of trimers) interface [polypeptide binding]; other site 682795002340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002341 D-galactonate transporter; Region: 2A0114; TIGR00893 682795002342 putative substrate translocation pore; other site 682795002343 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 682795002344 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 682795002345 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 682795002346 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002347 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 682795002348 active site lid residues [active] 682795002349 substrate binding pocket [chemical binding]; other site 682795002350 catalytic residues [active] 682795002351 substrate-Mg2+ binding site; other site 682795002352 aspartate-rich region 1; other site 682795002353 aspartate-rich region 2; other site 682795002354 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002355 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 682795002356 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795002357 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 682795002358 putative active site [active] 682795002359 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002360 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795002361 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 682795002362 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 682795002363 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 682795002364 Domain of unknown function (DUF303); Region: DUF303; pfam03629 682795002365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002366 metabolite-proton symporter; Region: 2A0106; TIGR00883 682795002367 putative substrate translocation pore; other site 682795002368 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795002369 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795002370 active site 682795002371 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 682795002372 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 682795002373 Transcriptional regulators [Transcription]; Region: MarR; COG1846 682795002374 MarR family; Region: MarR_2; pfam12802 682795002375 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 682795002376 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 682795002377 dimer interface [polypeptide binding]; other site 682795002378 active site 682795002379 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795002380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795002381 NAD(P) binding site [chemical binding]; other site 682795002382 active site 682795002383 Cupin domain; Region: Cupin_2; pfam07883 682795002384 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 682795002385 Uncharacterized conserved protein [Function unknown]; Region: COG2128 682795002386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795002387 DNA-binding site [nucleotide binding]; DNA binding site 682795002388 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 682795002389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795002390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795002391 homodimer interface [polypeptide binding]; other site 682795002392 catalytic residue [active] 682795002393 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 682795002394 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 682795002395 catalytic triad [active] 682795002396 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 682795002397 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 682795002398 NodB motif; other site 682795002399 active site 682795002400 catalytic site [active] 682795002401 metal binding site [ion binding]; metal-binding site 682795002402 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 682795002403 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 682795002404 tetramer interface [polypeptide binding]; other site 682795002405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795002406 catalytic residue [active] 682795002407 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 682795002408 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 682795002409 tetramer interface [polypeptide binding]; other site 682795002410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795002411 catalytic residue [active] 682795002412 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 682795002413 lipoyl attachment site [posttranslational modification]; other site 682795002414 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 682795002415 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 682795002416 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 682795002417 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 682795002418 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 682795002419 ligand binding site; other site 682795002420 oligomer interface; other site 682795002421 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 682795002422 dimer interface [polypeptide binding]; other site 682795002423 N-terminal domain interface [polypeptide binding]; other site 682795002424 sulfate 1 binding site; other site 682795002425 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 682795002426 EamA-like transporter family; Region: EamA; pfam00892 682795002427 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795002428 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 682795002429 metal ion-dependent adhesion site (MIDAS); other site 682795002430 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795002431 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795002432 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795002433 metal ion-dependent adhesion site (MIDAS); other site 682795002434 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 682795002435 phosphate binding site [ion binding]; other site 682795002436 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 682795002437 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 682795002438 substrate binding site [chemical binding]; other site 682795002439 glutamase interaction surface [polypeptide binding]; other site 682795002440 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 682795002441 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 682795002442 putative active site [active] 682795002443 oxyanion strand; other site 682795002444 catalytic triad [active] 682795002445 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 682795002446 putative active site pocket [active] 682795002447 4-fold oligomerization interface [polypeptide binding]; other site 682795002448 metal binding residues [ion binding]; metal-binding site 682795002449 3-fold/trimer interface [polypeptide binding]; other site 682795002450 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 682795002451 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795002452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795002453 homodimer interface [polypeptide binding]; other site 682795002454 catalytic residue [active] 682795002455 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 682795002456 histidinol dehydrogenase; Region: hisD; TIGR00069 682795002457 NAD binding site [chemical binding]; other site 682795002458 dimerization interface [polypeptide binding]; other site 682795002459 product binding site; other site 682795002460 substrate binding site [chemical binding]; other site 682795002461 zinc binding site [ion binding]; other site 682795002462 catalytic residues [active] 682795002463 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 682795002464 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 682795002465 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 682795002466 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 682795002467 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795002468 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 682795002469 active site clefts [active] 682795002470 zinc binding site [ion binding]; other site 682795002471 dimer interface [polypeptide binding]; other site 682795002472 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 682795002473 putative catalytic residue [active] 682795002474 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795002475 peptidase domain interface [polypeptide binding]; other site 682795002476 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795002477 active site 682795002478 catalytic triad [active] 682795002479 calcium binding site [ion binding]; other site 682795002480 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 682795002481 active site 682795002482 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 682795002483 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 682795002484 rRNA binding site [nucleotide binding]; other site 682795002485 predicted 30S ribosome binding site; other site 682795002486 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 682795002487 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 682795002488 30S ribosomal protein S13; Region: bact_S13; TIGR03631 682795002489 30S ribosomal protein S11; Validated; Region: PRK05309 682795002490 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 682795002491 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 682795002492 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 682795002493 RNA binding surface [nucleotide binding]; other site 682795002494 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 682795002495 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 682795002496 alphaNTD homodimer interface [polypeptide binding]; other site 682795002497 alphaNTD - beta interaction site [polypeptide binding]; other site 682795002498 alphaNTD - beta' interaction site [polypeptide binding]; other site 682795002499 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 682795002500 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 682795002501 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 682795002502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795002503 Walker A/P-loop; other site 682795002504 ATP binding site [chemical binding]; other site 682795002505 Q-loop/lid; other site 682795002506 ABC transporter signature motif; other site 682795002507 Walker B; other site 682795002508 D-loop; other site 682795002509 H-loop/switch region; other site 682795002510 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 682795002511 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 682795002512 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 682795002513 putative acyl-acceptor binding pocket; other site 682795002514 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 682795002515 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 682795002516 5'-3' exonuclease; Region: 53EXOc; smart00475 682795002517 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 682795002518 active site 682795002519 metal binding site 1 [ion binding]; metal-binding site 682795002520 putative 5' ssDNA interaction site; other site 682795002521 metal binding site 3; metal-binding site 682795002522 metal binding site 2 [ion binding]; metal-binding site 682795002523 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 682795002524 putative DNA binding site [nucleotide binding]; other site 682795002525 putative metal binding site [ion binding]; other site 682795002526 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 682795002527 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 682795002528 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 682795002529 active site 682795002530 DNA binding site [nucleotide binding] 682795002531 catalytic site [active] 682795002532 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 682795002533 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 682795002534 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 682795002535 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 682795002536 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 682795002537 putative active site [active] 682795002538 putative substrate binding site [chemical binding]; other site 682795002539 putative cosubstrate binding site; other site 682795002540 catalytic site [active] 682795002541 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 682795002542 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 682795002543 active site 682795002544 substrate binding site [chemical binding]; other site 682795002545 metal binding site [ion binding]; metal-binding site 682795002546 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795002547 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795002548 metal ion-dependent adhesion site (MIDAS); other site 682795002549 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 682795002550 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795002551 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 682795002552 catalytic residues [active] 682795002553 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 682795002554 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 682795002555 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 682795002556 domain interfaces; other site 682795002557 active site 682795002558 maltose O-acetyltransferase; Provisional; Region: PRK10092 682795002559 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 682795002560 trimer interface [polypeptide binding]; other site 682795002561 active site 682795002562 substrate binding site [chemical binding]; other site 682795002563 CoA binding site [chemical binding]; other site 682795002564 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 682795002565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795002566 ATP binding site [chemical binding]; other site 682795002567 Mg2+ binding site [ion binding]; other site 682795002568 G-X-G motif; other site 682795002569 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 682795002570 ATP binding site [chemical binding]; other site 682795002571 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 682795002572 cytidylate kinase; Provisional; Region: cmk; PRK00023 682795002573 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 682795002574 CMP-binding site; other site 682795002575 The sites determining sugar specificity; other site 682795002576 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 682795002577 DNA-binding site [nucleotide binding]; DNA binding site 682795002578 RNA-binding motif; other site 682795002579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795002580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795002581 NAD(P) binding site [chemical binding]; other site 682795002582 active site 682795002583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795002584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795002585 Transmembrane secretion effector; Region: MFS_3; pfam05977 682795002586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795002587 putative substrate translocation pore; other site 682795002588 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 682795002589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795002590 non-specific DNA binding site [nucleotide binding]; other site 682795002591 salt bridge; other site 682795002592 sequence-specific DNA binding site [nucleotide binding]; other site 682795002593 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 682795002594 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 682795002595 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 682795002596 TPP-binding site [chemical binding]; other site 682795002597 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 682795002598 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 682795002599 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 682795002600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795002601 FeS/SAM binding site; other site 682795002602 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 682795002603 Integrase core domain; Region: rve; pfam00665 682795002604 RNB domain; Region: RNB; pfam00773 682795002605 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 682795002606 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002607 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 682795002608 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 682795002609 active site 682795002610 catalytic triad [active] 682795002611 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 682795002612 active site 682795002613 catalytic triad [active] 682795002614 RES domain; Region: RES; pfam08808 682795002615 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 682795002616 phosphoglucomutase; Validated; Region: PRK07564 682795002617 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 682795002618 active site 682795002619 substrate binding site [chemical binding]; other site 682795002620 metal binding site [ion binding]; metal-binding site 682795002621 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 682795002622 Zn binding site [ion binding]; other site 682795002623 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 682795002624 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 682795002625 active site 682795002626 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 682795002627 synthetase active site [active] 682795002628 NTP binding site [chemical binding]; other site 682795002629 metal binding site [ion binding]; metal-binding site 682795002630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795002631 non-specific DNA binding site [nucleotide binding]; other site 682795002632 salt bridge; other site 682795002633 sequence-specific DNA binding site [nucleotide binding]; other site 682795002634 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795002635 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 682795002636 deoxyhypusine synthase; Region: dhys; TIGR00321 682795002637 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 682795002638 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 682795002639 ATP-binding site [chemical binding]; other site 682795002640 Sugar specificity; other site 682795002641 Pyrimidine base specificity; other site 682795002642 purine nucleoside phosphorylase; Provisional; Region: PRK08202 682795002643 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 682795002644 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 682795002645 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 682795002646 Nucleoside recognition; Region: Gate; pfam07670 682795002647 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 682795002648 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 682795002649 DNA-binding site [nucleotide binding]; DNA binding site 682795002650 RNA-binding motif; other site 682795002651 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 682795002652 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 682795002653 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 682795002654 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 682795002655 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 682795002656 active site 682795002657 catalytic motif [active] 682795002658 Zn binding site [ion binding]; other site 682795002659 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 682795002660 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 682795002661 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 682795002662 Walker A motif; other site 682795002663 ATP binding site [chemical binding]; other site 682795002664 Walker B motif; other site 682795002665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795002666 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 682795002667 ATP binding site [chemical binding]; other site 682795002668 putative Mg++ binding site [ion binding]; other site 682795002669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 682795002670 nucleotide binding region [chemical binding]; other site 682795002671 ATP-binding site [chemical binding]; other site 682795002672 DEAD/H associated; Region: DEAD_assoc; pfam08494 682795002673 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 682795002674 Active site serine [active] 682795002675 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 682795002676 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 682795002677 putative hydrophobic ligand binding site [chemical binding]; other site 682795002678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795002679 dimerization interface [polypeptide binding]; other site 682795002680 putative DNA binding site [nucleotide binding]; other site 682795002681 putative Zn2+ binding site [ion binding]; other site 682795002682 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 682795002683 Domain of unknown function (DUF305); Region: DUF305; pfam03713 682795002684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795002685 DNA binding residues [nucleotide binding] 682795002686 dimerization interface [polypeptide binding]; other site 682795002687 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 682795002688 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795002689 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795002690 active site 682795002691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795002692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795002693 DNA binding site [nucleotide binding] 682795002694 Predicted integral membrane protein [Function unknown]; Region: COG5616 682795002695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795002696 TPR motif; other site 682795002697 TPR repeat; Region: TPR_11; pfam13414 682795002698 binding surface 682795002699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795002700 binding surface 682795002701 TPR motif; other site 682795002702 TPR repeat; Region: TPR_11; pfam13414 682795002703 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 682795002704 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795002705 Domain of unknown function (DUF718); Region: DUF718; pfam05336 682795002706 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 682795002707 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 682795002708 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 682795002709 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 682795002710 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 682795002711 Cysteine-rich domain; Region: CCG; pfam02754 682795002712 Cysteine-rich domain; Region: CCG; pfam02754 682795002713 rhamnose-proton symporter; Provisional; Region: PRK13499 682795002714 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 682795002715 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 682795002716 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 682795002717 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795002718 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 682795002719 ligand binding site [chemical binding]; other site 682795002720 short chain dehydrogenase; Validated; Region: PRK08324 682795002721 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 682795002722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795002723 NAD(P) binding site [chemical binding]; other site 682795002724 active site 682795002725 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 682795002726 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 682795002727 nucleotide binding site [chemical binding]; other site 682795002728 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 682795002729 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795002730 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 682795002731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 682795002732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795002733 dimer interface [polypeptide binding]; other site 682795002734 phosphorylation site [posttranslational modification] 682795002735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795002736 ATP binding site [chemical binding]; other site 682795002737 Mg2+ binding site [ion binding]; other site 682795002738 G-X-G motif; other site 682795002739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795002740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795002741 active site 682795002742 phosphorylation site [posttranslational modification] 682795002743 intermolecular recognition site; other site 682795002744 dimerization interface [polypeptide binding]; other site 682795002745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795002746 DNA binding site [nucleotide binding] 682795002747 Alginate lyase; Region: Alginate_lyase; pfam05426 682795002748 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795002749 beta-D-glucuronidase; Provisional; Region: PRK10150 682795002750 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795002751 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795002752 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795002753 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795002754 Predicted membrane protein [Function unknown]; Region: COG2259 682795002755 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 682795002756 active site 682795002757 DNA binding site [nucleotide binding] 682795002758 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 682795002759 active site 682795002760 SUMO-1 interface [polypeptide binding]; other site 682795002761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795002762 Coenzyme A binding pocket [chemical binding]; other site 682795002763 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 682795002764 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 682795002765 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 682795002766 DNA binding site [nucleotide binding] 682795002767 active site 682795002768 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 682795002769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795002770 catalytic residue [active] 682795002771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 682795002772 acyl-activating enzyme (AAE) consensus motif; other site 682795002773 active site 682795002774 AMP binding site [chemical binding]; other site 682795002775 CoA binding site [chemical binding]; other site 682795002776 MIP family channel proteins; Region: MIP; TIGR00861 682795002777 amphipathic channel; other site 682795002778 Asn-Pro-Ala signature motifs; other site 682795002779 GAF domain; Region: GAF_2; pfam13185 682795002780 GAF domain; Region: GAF; pfam01590 682795002781 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 682795002782 GAF domain; Region: GAF; pfam01590 682795002783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795002784 Walker A motif; other site 682795002785 ATP binding site [chemical binding]; other site 682795002786 Walker B motif; other site 682795002787 arginine finger; other site 682795002788 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 682795002789 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 682795002790 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 682795002791 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 682795002792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795002793 active site 682795002794 phosphorylation site [posttranslational modification] 682795002795 intermolecular recognition site; other site 682795002796 dimerization interface [polypeptide binding]; other site 682795002797 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 682795002798 intersubunit interface [polypeptide binding]; other site 682795002799 active site 682795002800 zinc binding site [ion binding]; other site 682795002801 Na+ binding site [ion binding]; other site 682795002802 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795002803 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 682795002804 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795002805 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 682795002806 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 682795002807 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 682795002808 putative NAD(P) binding site [chemical binding]; other site 682795002809 putative active site [active] 682795002810 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 682795002811 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 682795002812 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795002813 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795002814 DNA binding residues [nucleotide binding] 682795002815 Protein of unknown function, DUF417; Region: DUF417; cl01162 682795002816 mercuric reductase; Validated; Region: PRK06370 682795002817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795002818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 682795002819 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 682795002820 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795002821 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795002822 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795002823 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795002824 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 682795002825 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795002826 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795002827 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795002828 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795002829 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795002830 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 682795002831 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 682795002832 active site 682795002833 nucleophile elbow; other site 682795002834 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795002835 Carbohydrate-binding protein of the ER; Region: Malectin_like; pfam12819 682795002836 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795002837 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 682795002838 active site 682795002839 catalytic residues [active] 682795002840 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795002841 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795002842 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795002843 Carbohydrate-binding protein of the ER; Region: Malectin_like; pfam12819 682795002844 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795002845 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795002846 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 682795002847 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 682795002848 Active Sites [active] 682795002849 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 682795002850 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 682795002851 CysD dimerization site [polypeptide binding]; other site 682795002852 G1 box; other site 682795002853 putative GEF interaction site [polypeptide binding]; other site 682795002854 GTP/Mg2+ binding site [chemical binding]; other site 682795002855 Switch I region; other site 682795002856 G2 box; other site 682795002857 G3 box; other site 682795002858 Switch II region; other site 682795002859 G4 box; other site 682795002860 G5 box; other site 682795002861 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 682795002862 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 682795002863 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 682795002864 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 682795002865 Active Sites [active] 682795002866 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 682795002867 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 682795002868 XdhC Rossmann domain; Region: XdhC_C; pfam13478 682795002869 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 682795002870 Ligand binding site; other site 682795002871 metal-binding site 682795002872 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 682795002873 trehalose synthase; Region: treS_nterm; TIGR02456 682795002874 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 682795002875 active site 682795002876 catalytic site [active] 682795002877 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 682795002878 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 682795002879 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 682795002880 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 682795002881 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 682795002882 active site 682795002883 homodimer interface [polypeptide binding]; other site 682795002884 catalytic site [active] 682795002885 acceptor binding site [chemical binding]; other site 682795002886 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 682795002887 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 682795002888 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 682795002889 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 682795002890 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 682795002891 active site 682795002892 catalytic site [active] 682795002893 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 682795002894 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 682795002895 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 682795002896 catalytic site [active] 682795002897 active site 682795002898 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 682795002899 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 682795002900 dimer interface [polypeptide binding]; other site 682795002901 ADP-ribose binding site [chemical binding]; other site 682795002902 active site 682795002903 nudix motif; other site 682795002904 metal binding site [ion binding]; metal-binding site 682795002905 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 682795002906 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 682795002907 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795002908 metal ion-dependent adhesion site (MIDAS); other site 682795002909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795002910 S-adenosylmethionine binding site [chemical binding]; other site 682795002911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795002912 S-adenosylmethionine binding site [chemical binding]; other site 682795002913 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 682795002914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795002915 TPR motif; other site 682795002916 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 682795002917 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 682795002918 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 682795002919 GrpE; Region: GrpE; pfam01025 682795002920 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 682795002921 dimer interface [polypeptide binding]; other site 682795002922 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 682795002923 chaperone protein DnaJ; Provisional; Region: PRK10767 682795002924 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 682795002925 HSP70 interaction site [polypeptide binding]; other site 682795002926 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 682795002927 substrate binding site [polypeptide binding]; other site 682795002928 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 682795002929 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 682795002930 dimer interface [polypeptide binding]; other site 682795002931 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 682795002932 RNA methyltransferase, RsmE family; Region: TIGR00046 682795002933 CAAX protease self-immunity; Region: Abi; pfam02517 682795002934 putative acyltransferase; Provisional; Region: PRK05790 682795002935 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 682795002936 dimer interface [polypeptide binding]; other site 682795002937 active site 682795002938 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 682795002939 Predicted transcriptional regulator [Transcription]; Region: COG3905 682795002940 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 682795002941 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 682795002942 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 682795002943 Protein of unknown function (DUF419); Region: DUF419; pfam04237 682795002944 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 682795002945 Phosphotransferase enzyme family; Region: APH; pfam01636 682795002946 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 682795002947 active site 682795002948 ATP binding site [chemical binding]; other site 682795002949 substrate binding site [chemical binding]; other site 682795002950 dimer interface [polypeptide binding]; other site 682795002951 HEAT repeats; Region: HEAT_2; pfam13646 682795002952 HEAT repeats; Region: HEAT_2; pfam13646 682795002953 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 682795002954 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 682795002955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795002956 Walker A motif; other site 682795002957 ATP binding site [chemical binding]; other site 682795002958 Walker B motif; other site 682795002959 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 682795002960 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 682795002961 transcription termination factor Rho; Provisional; Region: rho; PRK09376 682795002962 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 682795002963 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 682795002964 RNA binding site [nucleotide binding]; other site 682795002965 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 682795002966 multimer interface [polypeptide binding]; other site 682795002967 Walker A motif; other site 682795002968 ATP binding site [chemical binding]; other site 682795002969 Walker B motif; other site 682795002970 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 682795002971 Lumazine binding domain; Region: Lum_binding; pfam00677 682795002972 Lumazine binding domain; Region: Lum_binding; pfam00677 682795002973 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 682795002974 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 682795002975 catalytic motif [active] 682795002976 Zn binding site [ion binding]; other site 682795002977 RibD C-terminal domain; Region: RibD_C; cl17279 682795002978 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 682795002979 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 682795002980 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795002981 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 682795002982 putative active site [active] 682795002983 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 682795002984 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 682795002985 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 682795002986 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 682795002987 competence damage-inducible protein A; Provisional; Region: PRK00549 682795002988 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 682795002989 putative MPT binding site; other site 682795002990 Competence-damaged protein; Region: CinA; pfam02464 682795002991 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 682795002992 structural tetrad; other site 682795002993 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 682795002994 tetramer interfaces [polypeptide binding]; other site 682795002995 binuclear metal-binding site [ion binding]; other site 682795002996 Domain of unknown function (DUF329); Region: DUF329; pfam03884 682795002997 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 682795002998 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 682795002999 Predicted transcriptional regulators [Transcription]; Region: COG1733 682795003000 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 682795003001 short chain dehydrogenase; Provisional; Region: PRK08303 682795003002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795003003 NAD(P) binding site [chemical binding]; other site 682795003004 active site 682795003005 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 682795003006 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 682795003007 active site 682795003008 Zn binding site [ion binding]; other site 682795003009 MutS domain III; Region: MutS_III; cl17822 682795003010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795003011 Walker A/P-loop; other site 682795003012 ATP binding site [chemical binding]; other site 682795003013 Q-loop/lid; other site 682795003014 ABC transporter signature motif; other site 682795003015 Walker B; other site 682795003016 D-loop; other site 682795003017 H-loop/switch region; other site 682795003018 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 682795003019 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 682795003020 dimer interface [polypeptide binding]; other site 682795003021 active site 682795003022 CoA binding pocket [chemical binding]; other site 682795003023 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 682795003024 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 682795003025 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 682795003026 DNA protecting protein DprA; Region: dprA; TIGR00732 682795003027 DNA topoisomerase I; Validated; Region: PRK06599 682795003028 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 682795003029 active site 682795003030 interdomain interaction site; other site 682795003031 putative metal-binding site [ion binding]; other site 682795003032 nucleotide binding site [chemical binding]; other site 682795003033 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 682795003034 domain I; other site 682795003035 phosphate binding site [ion binding]; other site 682795003036 Bacterial DNA topoisomerase I DNA-binding domain; Region: TOP1Ac; smart00437 682795003037 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 682795003038 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 682795003039 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]; Region: RPB9; COG1594 682795003040 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 682795003041 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 682795003042 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 682795003043 Domain of unknown function (DUF427); Region: DUF427; pfam04248 682795003044 ketol-acid reductoisomerase; Provisional; Region: PRK05479 682795003045 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 682795003046 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 682795003047 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 682795003048 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 682795003049 putative valine binding site [chemical binding]; other site 682795003050 dimer interface [polypeptide binding]; other site 682795003051 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 682795003052 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 682795003053 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 682795003054 PYR/PP interface [polypeptide binding]; other site 682795003055 dimer interface [polypeptide binding]; other site 682795003056 TPP binding site [chemical binding]; other site 682795003057 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 682795003058 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 682795003059 TPP-binding site [chemical binding]; other site 682795003060 dimer interface [polypeptide binding]; other site 682795003061 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 682795003062 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 682795003063 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 682795003064 substrate binding site [chemical binding]; other site 682795003065 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 682795003066 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 682795003067 substrate binding site [chemical binding]; other site 682795003068 ligand binding site [chemical binding]; other site 682795003069 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 682795003070 tartrate dehydrogenase; Region: TTC; TIGR02089 682795003071 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 682795003072 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 682795003073 active site 682795003074 catalytic residues [active] 682795003075 metal binding site [ion binding]; metal-binding site 682795003076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795003077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795003078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 682795003079 dimerization interface [polypeptide binding]; other site 682795003080 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 682795003081 dimer interface [polypeptide binding]; other site 682795003082 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 682795003083 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 682795003084 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795003085 Predicted membrane protein [Function unknown]; Region: COG2323 682795003086 acetyl-CoA synthetase; Provisional; Region: PRK00174 682795003087 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 682795003088 active site 682795003089 CoA binding site [chemical binding]; other site 682795003090 acyl-activating enzyme (AAE) consensus motif; other site 682795003091 AMP binding site [chemical binding]; other site 682795003092 acetate binding site [chemical binding]; other site 682795003093 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 682795003094 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 682795003095 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 682795003096 FecR protein; Region: FecR; pfam04773 682795003097 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 682795003098 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 682795003099 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795003100 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 682795003101 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795003102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795003103 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 682795003104 short chain dehydrogenase; Provisional; Region: PRK08263 682795003105 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 682795003106 NADP binding site [chemical binding]; other site 682795003107 active site 682795003108 steroid binding site; other site 682795003109 adenylosuccinate lyase; Provisional; Region: PRK07492 682795003110 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 682795003111 tetramer interface [polypeptide binding]; other site 682795003112 active site 682795003113 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 682795003114 MarR family; Region: MarR_2; cl17246 682795003115 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 682795003116 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 682795003117 Cl- selectivity filter; other site 682795003118 Cl- binding residues [ion binding]; other site 682795003119 pore gating glutamate residue; other site 682795003120 dimer interface [polypeptide binding]; other site 682795003121 FOG: CBS domain [General function prediction only]; Region: COG0517 682795003122 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 682795003123 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 682795003124 catalytic residues [active] 682795003125 Domain of unknown function DUF302; Region: DUF302; cl01364 682795003126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795003127 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795003128 NAD(P) binding site [chemical binding]; other site 682795003129 active site 682795003130 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 682795003131 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 682795003132 nucleoside/Zn binding site; other site 682795003133 dimer interface [polypeptide binding]; other site 682795003134 catalytic motif [active] 682795003135 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795003136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795003137 active site 682795003138 RibD C-terminal domain; Region: RibD_C; cl17279 682795003139 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 682795003140 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 682795003141 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 682795003142 Protein of unknown function (DUF433); Region: DUF433; pfam04255 682795003143 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 682795003144 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795003145 catalytic residues [active] 682795003146 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795003147 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 682795003148 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 682795003149 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 682795003150 putative active site; other site 682795003151 catalytic triad [active] 682795003152 putative dimer interface [polypeptide binding]; other site 682795003153 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 682795003154 putative active site [active] 682795003155 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 682795003156 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 682795003157 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 682795003158 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 682795003159 isocitrate dehydrogenase; Validated; Region: PRK07362 682795003160 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 682795003161 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 682795003162 oligomeric interface; other site 682795003163 putative active site [active] 682795003164 homodimer interface [polypeptide binding]; other site 682795003165 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 682795003166 malate dehydrogenase; Reviewed; Region: PRK06223 682795003167 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 682795003168 NAD(P) binding site [chemical binding]; other site 682795003169 dimer interface [polypeptide binding]; other site 682795003170 tetramer (dimer of dimers) interface [polypeptide binding]; other site 682795003171 substrate binding site [chemical binding]; other site 682795003172 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 682795003173 active site 682795003174 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 682795003175 active site 682795003176 Stress responsive A/B Barrel Domain; Region: Dabb; cl17744 682795003177 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 682795003178 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 682795003179 active site 682795003180 dimer interface [polypeptide binding]; other site 682795003181 Domain of unknown function (DUF336); Region: DUF336; cl01249 682795003182 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 682795003183 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 682795003184 Transposase IS200 like; Region: Y1_Tnp; pfam01797 682795003185 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 682795003186 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 682795003187 GDYXXLXY protein; Region: GDYXXLXY; cl02066 682795003188 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 682795003189 L-aspartate oxidase; Provisional; Region: PRK06175 682795003190 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 682795003191 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 682795003192 putative Iron-sulfur protein interface [polypeptide binding]; other site 682795003193 proximal heme binding site [chemical binding]; other site 682795003194 distal heme binding site [chemical binding]; other site 682795003195 putative dimer interface [polypeptide binding]; other site 682795003196 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 682795003197 active site 682795003198 dimerization interface [polypeptide binding]; other site 682795003199 Predicted permease; Region: DUF318; cl17795 682795003200 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 682795003201 Asp-box motif; other site 682795003202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 682795003203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 682795003204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795003205 Walker A/P-loop; other site 682795003206 ATP binding site [chemical binding]; other site 682795003207 Q-loop/lid; other site 682795003208 ABC transporter signature motif; other site 682795003209 Walker B; other site 682795003210 D-loop; other site 682795003211 H-loop/switch region; other site 682795003212 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 682795003213 Predicted permeases [General function prediction only]; Region: COG0795 682795003214 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 682795003215 Predicted permeases [General function prediction only]; Region: COG0795 682795003216 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 682795003217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795003218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795003219 active site 682795003220 phosphorylation site [posttranslational modification] 682795003221 intermolecular recognition site; other site 682795003222 dimerization interface [polypeptide binding]; other site 682795003223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795003224 DNA binding site [nucleotide binding] 682795003225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795003226 dimer interface [polypeptide binding]; other site 682795003227 phosphorylation site [posttranslational modification] 682795003228 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 682795003229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795003230 ATP binding site [chemical binding]; other site 682795003231 Mg2+ binding site [ion binding]; other site 682795003232 G-X-G motif; other site 682795003233 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 682795003234 Fatty acid desaturase; Region: FA_desaturase; pfam00487 682795003235 Di-iron ligands [ion binding]; other site 682795003236 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 682795003237 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 682795003238 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 682795003239 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 682795003240 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 682795003241 protein binding site [polypeptide binding]; other site 682795003242 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 682795003243 protein binding site [polypeptide binding]; other site 682795003244 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 682795003245 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 682795003246 putative metal binding site [ion binding]; other site 682795003247 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 682795003248 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 682795003249 dimerization interface 3.5A [polypeptide binding]; other site 682795003250 active site 682795003251 Outer membrane efflux protein; Region: OEP; pfam02321 682795003252 Outer membrane efflux protein; Region: OEP; pfam02321 682795003253 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 682795003254 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 682795003255 catalytic residues [active] 682795003256 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 682795003257 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 682795003258 Mechanosensitive ion channel; Region: MS_channel; pfam00924 682795003259 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 682795003260 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 682795003261 TPP-binding site [chemical binding]; other site 682795003262 tetramer interface [polypeptide binding]; other site 682795003263 heterodimer interface [polypeptide binding]; other site 682795003264 phosphorylation loop region [posttranslational modification] 682795003265 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 682795003266 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 682795003267 alpha subunit interface [polypeptide binding]; other site 682795003268 TPP binding site [chemical binding]; other site 682795003269 heterodimer interface [polypeptide binding]; other site 682795003270 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 682795003271 MgtE intracellular N domain; Region: MgtE_N; cl15244 682795003272 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 682795003273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 682795003274 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 682795003275 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795003276 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 682795003277 iron-sulfur cluster [ion binding]; other site 682795003278 [2Fe-2S] cluster binding site [ion binding]; other site 682795003279 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 682795003280 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 682795003281 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 682795003282 catalytic site [active] 682795003283 subunit interface [polypeptide binding]; other site 682795003284 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 682795003285 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 682795003286 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 682795003287 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 682795003288 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 682795003289 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 682795003290 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 682795003291 ATP-grasp domain; Region: ATP-grasp_4; cl17255 682795003292 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 682795003293 IMP binding site; other site 682795003294 dimer interface [polypeptide binding]; other site 682795003295 interdomain contacts; other site 682795003296 partial ornithine binding site; other site 682795003297 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 682795003298 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 682795003299 inhibitor site; inhibition site 682795003300 active site 682795003301 dimer interface [polypeptide binding]; other site 682795003302 catalytic residue [active] 682795003303 Class I aldolases; Region: Aldolase_Class_I; cl17187 682795003304 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 682795003305 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795003306 Transcriptional regulator PadR-like family; Region: PadR; cl17335 682795003307 Predicted transcriptional regulators [Transcription]; Region: COG1695 682795003308 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 682795003309 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 682795003310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 682795003311 TPR motif; other site 682795003312 binding surface 682795003313 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 682795003314 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 682795003315 ligand binding site [chemical binding]; other site 682795003316 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 682795003317 TolB amino-terminal domain; Region: TolB_N; pfam04052 682795003318 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795003319 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795003320 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795003321 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 682795003322 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 682795003323 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 682795003324 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 682795003325 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 682795003326 Walker A/P-loop; other site 682795003327 ATP binding site [chemical binding]; other site 682795003328 Q-loop/lid; other site 682795003329 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 682795003330 ABC transporter signature motif; other site 682795003331 Walker B; other site 682795003332 D-loop; other site 682795003333 H-loop/switch region; other site 682795003334 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 682795003335 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 682795003336 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 682795003337 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 682795003338 Active site cavity [active] 682795003339 catalytic acid [active] 682795003340 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 682795003341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795003342 FeS/SAM binding site; other site 682795003343 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 682795003344 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 682795003345 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 682795003346 putative NADP binding site [chemical binding]; other site 682795003347 putative substrate binding site [chemical binding]; other site 682795003348 active site 682795003349 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 682795003350 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 682795003351 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 682795003352 NAD(P) binding site [chemical binding]; other site 682795003353 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 682795003354 Putative zinc-finger; Region: zf-HC2; pfam13490 682795003355 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 682795003356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795003357 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795003358 DNA binding residues [nucleotide binding] 682795003359 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 682795003360 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795003361 active site 682795003362 metal binding site [ion binding]; metal-binding site 682795003363 Haem-binding domain; Region: Haem_bd; pfam14376 682795003364 Cytochrome c2 [Energy production and conversion]; Region: COG3474 682795003365 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 682795003366 Subunit I/III interface [polypeptide binding]; other site 682795003367 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 682795003368 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cd00919 682795003369 D-pathway; other site 682795003370 Low-spin heme binding site [chemical binding]; other site 682795003371 Putative water exit pathway; other site 682795003372 Binuclear center (active site) [active] 682795003373 K-pathway; other site 682795003374 Putative proton exit pathway; other site 682795003375 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 682795003376 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 682795003377 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 682795003378 predicted active site [active] 682795003379 catalytic triad [active] 682795003380 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 682795003381 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 682795003382 active site 682795003383 multimer interface [polypeptide binding]; other site 682795003384 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 682795003385 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 682795003386 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 682795003387 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 682795003388 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 682795003389 polyphosphate kinase; Provisional; Region: PRK05443 682795003390 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 682795003391 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 682795003392 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 682795003393 putative active site [active] 682795003394 catalytic site [active] 682795003395 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 682795003396 putative domain interface [polypeptide binding]; other site 682795003397 putative active site [active] 682795003398 catalytic site [active] 682795003399 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 682795003400 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 682795003401 tetrameric interface [polypeptide binding]; other site 682795003402 NAD binding site [chemical binding]; other site 682795003403 catalytic residues [active] 682795003404 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 682795003405 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 682795003406 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 682795003407 active site 682795003408 DNA binding site [nucleotide binding] 682795003409 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 682795003410 DNA binding site [nucleotide binding] 682795003411 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 682795003412 nucleotide binding site [chemical binding]; other site 682795003413 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 682795003414 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 682795003415 putative DNA binding site [nucleotide binding]; other site 682795003416 putative homodimer interface [polypeptide binding]; other site 682795003417 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 682795003418 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 682795003419 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795003420 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795003421 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 682795003422 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795003423 putative active site [active] 682795003424 metal binding site [ion binding]; metal-binding site 682795003425 homodimer binding site [polypeptide binding]; other site 682795003426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795003427 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 682795003428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795003429 homodimer interface [polypeptide binding]; other site 682795003430 catalytic residue [active] 682795003431 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 682795003432 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 682795003433 dimer interface [polypeptide binding]; other site 682795003434 putative anticodon binding site; other site 682795003435 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 682795003436 motif 1; other site 682795003437 active site 682795003438 motif 2; other site 682795003439 motif 3; other site 682795003440 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 682795003441 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 682795003442 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 682795003443 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 682795003444 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 682795003445 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 682795003446 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 682795003447 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 682795003448 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 682795003449 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 682795003450 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 682795003451 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 682795003452 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 682795003453 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 682795003454 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 682795003455 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 682795003456 catalytic loop [active] 682795003457 iron binding site [ion binding]; other site 682795003458 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 682795003459 4Fe-4S binding domain; Region: Fer4; pfam00037 682795003460 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 682795003461 molybdopterin cofactor binding site; other site 682795003462 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 682795003463 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 682795003464 SLBB domain; Region: SLBB; pfam10531 682795003465 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 682795003466 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 682795003467 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 682795003468 putative dimer interface [polypeptide binding]; other site 682795003469 [2Fe-2S] cluster binding site [ion binding]; other site 682795003470 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 682795003471 NADH dehydrogenase subunit D; Validated; Region: PRK06075 682795003472 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 682795003473 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 682795003474 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 682795003475 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 682795003476 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 682795003477 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 682795003478 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 682795003479 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795003480 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 682795003481 ThiS interaction site; other site 682795003482 putative active site [active] 682795003483 tetramer interface [polypeptide binding]; other site 682795003484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795003485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795003486 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 682795003487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795003488 NAD(P) binding site [chemical binding]; other site 682795003489 active site 682795003490 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 682795003491 Uncharacterized conserved protein [Function unknown]; Region: COG4198 682795003492 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795003493 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 682795003494 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 682795003495 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795003496 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795003497 metal ion-dependent adhesion site (MIDAS); other site 682795003498 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 682795003499 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 682795003500 dimer interface [polypeptide binding]; other site 682795003501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795003502 catalytic residue [active] 682795003503 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 682795003504 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 682795003505 acyl-activating enzyme (AAE) consensus motif; other site 682795003506 putative AMP binding site [chemical binding]; other site 682795003507 putative active site [active] 682795003508 putative CoA binding site [chemical binding]; other site 682795003509 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 682795003510 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 682795003511 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 682795003512 Helix-turn-helix domain; Region: HTH_17; pfam12728 682795003513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 682795003514 Histidine kinase; Region: His_kinase; pfam06580 682795003515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795003516 ATP binding site [chemical binding]; other site 682795003517 Mg2+ binding site [ion binding]; other site 682795003518 G-X-G motif; other site 682795003519 enolase; Provisional; Region: eno; PRK00077 682795003520 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 682795003521 dimer interface [polypeptide binding]; other site 682795003522 metal binding site [ion binding]; metal-binding site 682795003523 substrate binding pocket [chemical binding]; other site 682795003524 phosphoglyceromutase; Provisional; Region: PRK05434 682795003525 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 682795003526 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 682795003527 Large family of predicted nucleotide-binding domains; Region: PINc; smart00670 682795003528 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 682795003529 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 682795003530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795003531 active site 682795003532 metal binding site [ion binding]; metal-binding site 682795003533 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 682795003534 Helix-turn-helix domain; Region: HTH_38; pfam13936 682795003535 Integrase core domain; Region: rve; pfam00665 682795003536 recombination protein RecR; Reviewed; Region: recR; PRK00076 682795003537 RecR protein; Region: RecR; pfam02132 682795003538 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 682795003539 putative active site [active] 682795003540 putative metal-binding site [ion binding]; other site 682795003541 tetramer interface [polypeptide binding]; other site 682795003542 hypothetical protein; Validated; Region: PRK00153 682795003543 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 682795003544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795003545 Walker A motif; other site 682795003546 ATP binding site [chemical binding]; other site 682795003547 Walker B motif; other site 682795003548 arginine finger; other site 682795003549 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 682795003550 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 682795003551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795003552 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795003553 binding surface 682795003554 TPR motif; other site 682795003555 Cytochrome C biogenesis protein; Region: CcmH; cl01179 682795003556 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 682795003557 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 682795003558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795003559 active site 682795003560 phosphorylation site [posttranslational modification] 682795003561 intermolecular recognition site; other site 682795003562 dimerization interface [polypeptide binding]; other site 682795003563 Cupin domain; Region: Cupin_2; pfam07883 682795003564 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 682795003565 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 682795003566 active site 682795003567 ATP binding site [chemical binding]; other site 682795003568 substrate binding site [chemical binding]; other site 682795003569 activation loop (A-loop); other site 682795003570 Predicted integral membrane protein [Function unknown]; Region: COG5616 682795003571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795003572 binding surface 682795003573 TPR motif; other site 682795003574 TPR repeat; Region: TPR_11; pfam13414 682795003575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795003576 binding surface 682795003577 TPR motif; other site 682795003578 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 682795003579 Helix-turn-helix domain; Region: HTH_38; pfam13936 682795003580 Integrase core domain; Region: rve; pfam00665 682795003581 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 682795003582 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 682795003583 Escherichia coli YdjC-like family of proteins; Region: YdjC; cd10808 682795003584 putative active site [active] 682795003585 YdjC motif; other site 682795003586 Mg binding site [ion binding]; other site 682795003587 putative homodimer interface [polypeptide binding]; other site 682795003588 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 682795003589 active site 682795003590 oligomerization interface [polypeptide binding]; other site 682795003591 metal binding site [ion binding]; metal-binding site 682795003592 pantoate--beta-alanine ligase; Region: panC; TIGR00018 682795003593 Pantoate-beta-alanine ligase; Region: PanC; cd00560 682795003594 active site 682795003595 ATP-binding site [chemical binding]; other site 682795003596 pantoate-binding site; other site 682795003597 HXXH motif; other site 682795003598 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 682795003599 Flavoprotein; Region: Flavoprotein; pfam02441 682795003600 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 682795003601 quinolinate synthetase; Provisional; Region: PRK09375 682795003602 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 682795003603 L-aspartate oxidase; Provisional; Region: PRK06175 682795003604 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 682795003605 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 682795003606 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 682795003607 dimerization interface [polypeptide binding]; other site 682795003608 active site 682795003609 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 682795003610 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 682795003611 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795003612 catalytic residue [active] 682795003613 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795003614 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795003615 Amidase; Region: Amidase; pfam01425 682795003616 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795003617 Amidase; Region: Amidase; pfam01425 682795003618 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 682795003619 EamA-like transporter family; Region: EamA; pfam00892 682795003620 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795003621 Amidase; Region: Amidase; pfam01425 682795003622 Predicted integral membrane protein [Function unknown]; Region: COG5616 682795003623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795003624 TPR motif; other site 682795003625 binding surface 682795003626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795003627 TPR motif; other site 682795003628 binding surface 682795003629 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 682795003630 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 682795003631 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 682795003632 Family description; Region: VCBS; pfam13517 682795003633 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 682795003634 Phage Tail Collar Domain; Region: Collar; pfam07484 682795003635 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 682795003636 Phage Tail Collar Domain; Region: Collar; pfam07484 682795003637 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 682795003638 Phage Tail Collar Domain; Region: Collar; pfam07484 682795003639 Acetokinase family; Region: Acetate_kinase; cl17229 682795003640 propionate/acetate kinase; Provisional; Region: PRK12379 682795003641 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 682795003642 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795003643 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795003644 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 682795003645 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 682795003646 ApbE family; Region: ApbE; pfam02424 682795003647 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795003648 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795003649 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 682795003650 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 682795003651 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 682795003652 trimer interface [polypeptide binding]; other site 682795003653 active site 682795003654 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 682795003655 catalytic site [active] 682795003656 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 682795003657 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 682795003658 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 682795003659 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 682795003660 NADH(P)-binding; Region: NAD_binding_10; pfam13460 682795003661 NAD binding site [chemical binding]; other site 682795003662 substrate binding site [chemical binding]; other site 682795003663 putative active site [active] 682795003664 Predicted transcriptional regulators [Transcription]; Region: COG1733 682795003665 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 682795003666 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 682795003667 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 682795003668 active site 682795003669 cosubstrate binding site; other site 682795003670 substrate binding site [chemical binding]; other site 682795003671 catalytic site [active] 682795003672 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 682795003673 putative active site [active] 682795003674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795003675 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 682795003676 putative ADP-binding pocket [chemical binding]; other site 682795003677 Acyltransferase family; Region: Acyl_transf_3; pfam01757 682795003678 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 682795003679 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 682795003680 Ligand binding site; other site 682795003681 Putative Catalytic site; other site 682795003682 DXD motif; other site 682795003683 Methyltransferase domain; Region: Methyltransf_23; pfam13489 682795003684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795003685 S-adenosylmethionine binding site [chemical binding]; other site 682795003686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 682795003687 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 682795003688 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 682795003689 NAD(P) binding site [chemical binding]; other site 682795003690 homodimer interface [polypeptide binding]; other site 682795003691 substrate binding site [chemical binding]; other site 682795003692 active site 682795003693 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 682795003694 Catalytic site [active] 682795003695 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 682795003696 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 682795003697 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 682795003698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795003699 FeS/SAM binding site; other site 682795003700 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 682795003701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795003702 S-adenosylmethionine binding site [chemical binding]; other site 682795003703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 682795003704 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 682795003705 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 682795003706 active site 682795003707 homodimer interface [polypeptide binding]; other site 682795003708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795003709 binding surface 682795003710 TPR motif; other site 682795003711 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 682795003712 Chain length determinant protein; Region: Wzz; pfam02706 682795003713 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 682795003714 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 682795003715 Chain length determinant protein; Region: Wzz; cl15801 682795003716 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795003717 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 682795003718 O-Antigen ligase; Region: Wzy_C; pfam04932 682795003719 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 682795003720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795003721 S-adenosylmethionine binding site [chemical binding]; other site 682795003722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795003723 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 682795003724 putative ADP-binding pocket [chemical binding]; other site 682795003725 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 682795003726 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 682795003727 active site 682795003728 dimer interface [polypeptide binding]; other site 682795003729 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 682795003730 Ligand Binding Site [chemical binding]; other site 682795003731 Molecular Tunnel; other site 682795003732 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 682795003733 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 682795003734 putative ADP-binding pocket [chemical binding]; other site 682795003735 Bacterial sugar transferase; Region: Bac_transf; pfam02397 682795003736 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 682795003737 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 682795003738 putative trimer interface [polypeptide binding]; other site 682795003739 putative CoA binding site [chemical binding]; other site 682795003740 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 682795003741 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 682795003742 inhibitor-cofactor binding pocket; inhibition site 682795003743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795003744 catalytic residue [active] 682795003745 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 682795003746 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 682795003747 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 682795003748 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 682795003749 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 682795003750 NAD binding site [chemical binding]; other site 682795003751 substrate binding site [chemical binding]; other site 682795003752 active site 682795003753 FOG: CBS domain [General function prediction only]; Region: COG0517 682795003754 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 682795003755 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 682795003756 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 682795003757 Substrate binding site; other site 682795003758 metal-binding site 682795003759 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 682795003760 putative active site [active] 682795003761 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 682795003762 ligand binding site; other site 682795003763 tetramer interface; other site 682795003764 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 682795003765 NeuB family; Region: NeuB; pfam03102 682795003766 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 682795003767 NeuB binding interface [polypeptide binding]; other site 682795003768 putative substrate binding site [chemical binding]; other site 682795003769 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 682795003770 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 682795003771 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795003772 Cupin domain; Region: Cupin_2; pfam07883 682795003773 Predicted membrane protein [Function unknown]; Region: COG2259 682795003774 multidrug efflux system protein; Provisional; Region: PRK11431 682795003775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 682795003776 dimerization interface [polypeptide binding]; other site 682795003777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 682795003778 dimer interface [polypeptide binding]; other site 682795003779 phosphorylation site [posttranslational modification] 682795003780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795003781 ATP binding site [chemical binding]; other site 682795003782 Mg2+ binding site [ion binding]; other site 682795003783 G-X-G motif; other site 682795003784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795003785 osmolarity response regulator; Provisional; Region: ompR; PRK09468 682795003786 active site 682795003787 phosphorylation site [posttranslational modification] 682795003788 intermolecular recognition site; other site 682795003789 dimerization interface [polypeptide binding]; other site 682795003790 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795003791 DNA binding site [nucleotide binding] 682795003792 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795003793 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 682795003794 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795003795 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 682795003796 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 682795003797 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 682795003798 catalytic triad [active] 682795003799 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 682795003800 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 682795003801 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 682795003802 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 682795003803 Predicted membrane protein [Function unknown]; Region: COG2259 682795003804 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 682795003805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795003806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795003807 DNA binding residues [nucleotide binding] 682795003808 Putative zinc-finger; Region: zf-HC2; pfam13490 682795003809 Transcriptional regulators [Transcription]; Region: FadR; COG2186 682795003810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795003811 DNA-binding site [nucleotide binding]; DNA binding site 682795003812 FCD domain; Region: FCD; pfam07729 682795003813 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 682795003814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795003815 putative metal binding site [ion binding]; other site 682795003816 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 682795003817 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 682795003818 Glutamate binding site [chemical binding]; other site 682795003819 homodimer interface [polypeptide binding]; other site 682795003820 NAD binding site [chemical binding]; other site 682795003821 catalytic residues [active] 682795003822 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 682795003823 active site 682795003824 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 682795003825 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 682795003826 NodB motif; other site 682795003827 putative active site [active] 682795003828 putative catalytic site [active] 682795003829 putative Zn binding site [ion binding]; other site 682795003830 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 682795003831 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 682795003832 DXD motif; other site 682795003833 seryl-tRNA synthetase; Provisional; Region: PRK05431 682795003834 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 682795003835 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 682795003836 dimer interface [polypeptide binding]; other site 682795003837 active site 682795003838 motif 1; other site 682795003839 motif 2; other site 682795003840 motif 3; other site 682795003841 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 682795003842 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 682795003843 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 682795003844 Catalytic site [active] 682795003845 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 682795003846 triosephosphate isomerase; Provisional; Region: PRK14565 682795003847 substrate binding site [chemical binding]; other site 682795003848 dimer interface [polypeptide binding]; other site 682795003849 catalytic triad [active] 682795003850 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 682795003851 four helix bundle protein; Region: TIGR02436 682795003852 Phosphoglycerate kinase; Region: PGK; pfam00162 682795003853 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 682795003854 substrate binding site [chemical binding]; other site 682795003855 hinge regions; other site 682795003856 ADP binding site [chemical binding]; other site 682795003857 catalytic site [active] 682795003858 Predicted membrane protein [Function unknown]; Region: COG2855 682795003859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795003860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795003861 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 682795003862 putative dimerization interface [polypeptide binding]; other site 682795003863 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 682795003864 homotrimer interaction site [polypeptide binding]; other site 682795003865 putative active site [active] 682795003866 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 682795003867 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 682795003868 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 682795003869 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 682795003870 AAA domain; Region: AAA_33; pfam13671 682795003871 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 682795003872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795003873 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 682795003874 Walker A/P-loop; other site 682795003875 ATP binding site [chemical binding]; other site 682795003876 Q-loop/lid; other site 682795003877 ABC transporter signature motif; other site 682795003878 Walker B; other site 682795003879 D-loop; other site 682795003880 H-loop/switch region; other site 682795003881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795003882 dimer interface [polypeptide binding]; other site 682795003883 conserved gate region; other site 682795003884 ABC-ATPase subunit interface; other site 682795003885 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 682795003886 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 682795003887 DinB superfamily; Region: DinB_2; pfam12867 682795003888 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795003889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795003890 putative substrate translocation pore; other site 682795003891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795003892 MarR family; Region: MarR_2; cl17246 682795003893 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 682795003894 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 682795003895 dimerization interface [polypeptide binding]; other site 682795003896 active site 682795003897 phosphodiesterase YaeI; Provisional; Region: PRK11340 682795003898 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 682795003899 putative active site [active] 682795003900 putative metal binding site [ion binding]; other site 682795003901 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 682795003902 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 682795003903 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 682795003904 active site 682795003905 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 682795003906 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 682795003907 carboxyltransferase (CT) interaction site; other site 682795003908 biotinylation site [posttranslational modification]; other site 682795003909 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 682795003910 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 682795003911 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 682795003912 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 682795003913 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 682795003914 thiamine phosphate binding site [chemical binding]; other site 682795003915 active site 682795003916 pyrophosphate binding site [ion binding]; other site 682795003917 amino acid transporter; Region: 2A0306; TIGR00909 682795003918 amino acid transporter; Region: 2A0306; TIGR00909 682795003919 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 682795003920 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 682795003921 GIY-YIG motif/motif A; other site 682795003922 putative active site [active] 682795003923 putative metal binding site [ion binding]; other site 682795003924 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 682795003925 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 682795003926 Walker A/P-loop; other site 682795003927 ATP binding site [chemical binding]; other site 682795003928 Q-loop/lid; other site 682795003929 ABC transporter signature motif; other site 682795003930 Walker B; other site 682795003931 D-loop; other site 682795003932 H-loop/switch region; other site 682795003933 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795003934 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795003935 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 682795003936 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795003937 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 682795003938 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 682795003939 dimer interface [polypeptide binding]; other site 682795003940 active site 682795003941 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 682795003942 dimer interface [polypeptide binding]; other site 682795003943 active site 682795003944 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 682795003945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795003946 DNA-binding site [nucleotide binding]; DNA binding site 682795003947 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 682795003948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795003949 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 682795003950 pyruvate dehydrogenase; Provisional; Region: PRK09124 682795003951 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 682795003952 PYR/PP interface [polypeptide binding]; other site 682795003953 dimer interface [polypeptide binding]; other site 682795003954 tetramer interface [polypeptide binding]; other site 682795003955 TPP binding site [chemical binding]; other site 682795003956 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 682795003957 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 682795003958 TPP-binding site [chemical binding]; other site 682795003959 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795003960 nucleoside transporter; Region: 2A0110; TIGR00889 682795003961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795003962 putative substrate translocation pore; other site 682795003963 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 682795003964 4-alpha-glucanotransferase; Provisional; Region: PRK14508 682795003965 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 682795003966 BON domain; Region: BON; pfam04972 682795003967 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 682795003968 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795003969 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 682795003970 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 682795003971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795003972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795003973 short chain dehydrogenase; Provisional; Region: PRK06500 682795003974 classical (c) SDRs; Region: SDR_c; cd05233 682795003975 NAD(P) binding site [chemical binding]; other site 682795003976 active site 682795003977 DinB superfamily; Region: DinB_2; pfam12867 682795003978 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 682795003979 CGNR zinc finger; Region: zf-CGNR; pfam11706 682795003980 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 682795003981 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 682795003982 putative NAD(P) binding site [chemical binding]; other site 682795003983 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 682795003984 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 682795003985 nucleophilic elbow; other site 682795003986 catalytic triad; other site 682795003987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795003988 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 682795003989 dimerization interface [polypeptide binding]; other site 682795003990 metal binding site [ion binding]; metal-binding site 682795003991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 682795003992 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 682795003993 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 682795003994 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 682795003995 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 682795003996 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795003997 active site 682795003998 metal binding site [ion binding]; metal-binding site 682795003999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 682795004000 MarR family; Region: MarR; pfam01047 682795004001 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 682795004002 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795004003 PGAP1-like protein; Region: PGAP1; pfam07819 682795004004 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795004005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795004006 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 682795004007 dimerization interface [polypeptide binding]; other site 682795004008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 682795004009 SnoaL-like domain; Region: SnoaL_2; pfam12680 682795004010 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 682795004011 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 682795004012 tetramer interface [polypeptide binding]; other site 682795004013 heme binding pocket [chemical binding]; other site 682795004014 NADPH binding site [chemical binding]; other site 682795004015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795004016 Coenzyme A binding pocket [chemical binding]; other site 682795004017 EamA-like transporter family; Region: EamA; pfam00892 682795004018 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 682795004019 galactokinase; Provisional; Region: PRK03817 682795004020 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 682795004021 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 682795004022 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 682795004023 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 682795004024 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795004025 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795004026 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 682795004027 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 682795004028 putative active site [active] 682795004029 catalytic site [active] 682795004030 putative metal binding site [ion binding]; other site 682795004031 oligomer interface [polypeptide binding]; other site 682795004032 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 682795004033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795004034 NAD(P) binding site [chemical binding]; other site 682795004035 active site 682795004036 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 682795004037 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 682795004038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795004039 putative DNA binding site [nucleotide binding]; other site 682795004040 putative Zn2+ binding site [ion binding]; other site 682795004041 MarR family; Region: MarR_2; cl17246 682795004042 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 682795004043 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 682795004044 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 682795004045 active site 682795004046 catalytic site [active] 682795004047 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 682795004048 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 682795004049 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795004050 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795004051 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795004052 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795004053 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 682795004054 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 682795004055 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 682795004056 Zn binding site [ion binding]; other site 682795004057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795004058 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795004059 TPR motif; other site 682795004060 binding surface 682795004061 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 682795004062 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 682795004063 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795004064 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 682795004065 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 682795004066 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 682795004067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 682795004068 MarR family; Region: MarR; pfam01047 682795004069 H+ Antiporter protein; Region: 2A0121; TIGR00900 682795004070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795004071 putative substrate translocation pore; other site 682795004072 Isochorismatase family; Region: Isochorismatase; pfam00857 682795004073 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 682795004074 catalytic triad [active] 682795004075 conserved cis-peptide bond; other site 682795004076 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 682795004077 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 682795004078 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 682795004079 Walker A/P-loop; other site 682795004080 ATP binding site [chemical binding]; other site 682795004081 Q-loop/lid; other site 682795004082 ABC transporter signature motif; other site 682795004083 Walker B; other site 682795004084 D-loop; other site 682795004085 H-loop/switch region; other site 682795004086 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 682795004087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795004088 FeS/SAM binding site; other site 682795004089 HemN C-terminal domain; Region: HemN_C; pfam06969 682795004090 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 682795004091 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 682795004092 tetramer interface [polypeptide binding]; other site 682795004093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795004094 catalytic residue [active] 682795004095 CHASE3 domain; Region: CHASE3; pfam05227 682795004096 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 682795004097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795004098 putative active site [active] 682795004099 heme pocket [chemical binding]; other site 682795004100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795004101 dimer interface [polypeptide binding]; other site 682795004102 phosphorylation site [posttranslational modification] 682795004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795004104 ATP binding site [chemical binding]; other site 682795004105 Mg2+ binding site [ion binding]; other site 682795004106 G-X-G motif; other site 682795004107 Response regulator receiver domain; Region: Response_reg; pfam00072 682795004108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795004109 active site 682795004110 phosphorylation site [posttranslational modification] 682795004111 intermolecular recognition site; other site 682795004112 dimerization interface [polypeptide binding]; other site 682795004113 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 682795004114 Family description; Region: UvrD_C_2; pfam13538 682795004115 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 682795004116 probable DNA repair protein; Region: TIGR03623 682795004117 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 682795004118 SdiA-regulated; Region: SdiA-regulated; cd09971 682795004119 putative active site [active] 682795004120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795004121 putative substrate translocation pore; other site 682795004122 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 682795004123 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 682795004124 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 682795004125 Cu(I) binding site [ion binding]; other site 682795004126 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 682795004127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 682795004128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795004129 Walker A/P-loop; other site 682795004130 ATP binding site [chemical binding]; other site 682795004131 Q-loop/lid; other site 682795004132 ABC transporter signature motif; other site 682795004133 Walker B; other site 682795004134 D-loop; other site 682795004135 H-loop/switch region; other site 682795004136 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 682795004137 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 682795004138 putative active site [active] 682795004139 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 682795004140 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795004141 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 682795004142 Repair protein; Region: Repair_PSII; pfam04536 682795004143 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 682795004144 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 682795004145 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 682795004146 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 682795004147 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 682795004148 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 682795004149 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795004150 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795004151 active site 682795004152 catalytic tetrad [active] 682795004153 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 682795004154 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 682795004155 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 682795004156 active site 682795004157 8-oxo-dGMP binding site [chemical binding]; other site 682795004158 nudix motif; other site 682795004159 metal binding site [ion binding]; metal-binding site 682795004160 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 682795004161 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 682795004162 glucuronate isomerase; Reviewed; Region: PRK02925 682795004163 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 682795004164 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 682795004165 ATP-binding site [chemical binding]; other site 682795004166 Gluconate-6-phosphate binding site [chemical binding]; other site 682795004167 Shikimate kinase; Region: SKI; pfam01202 682795004168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795004169 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 682795004170 NAD(P) binding site [chemical binding]; other site 682795004171 active site 682795004172 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 682795004173 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795004174 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795004175 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795004176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795004177 putative substrate translocation pore; other site 682795004178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795004179 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795004180 muropeptide transporter; Validated; Region: ampG; cl17669 682795004181 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 682795004182 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 682795004183 nucleotide binding site [chemical binding]; other site 682795004184 NEF interaction site [polypeptide binding]; other site 682795004185 SBD interface [polypeptide binding]; other site 682795004186 endonuclease VIII; Provisional; Region: PRK10445 682795004187 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 682795004188 putative DNA binding site [nucleotide binding]; other site 682795004189 catalytic residue [active] 682795004190 putative H2TH interface [polypeptide binding]; other site 682795004191 putative catalytic residues [active] 682795004192 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 682795004193 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 682795004194 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 682795004195 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 682795004196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795004197 non-specific DNA binding site [nucleotide binding]; other site 682795004198 salt bridge; other site 682795004199 sequence-specific DNA binding site [nucleotide binding]; other site 682795004200 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 682795004201 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 682795004202 HSP70 interaction site [polypeptide binding]; other site 682795004203 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 682795004204 Zn binding sites [ion binding]; other site 682795004205 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 682795004206 dimer interface [polypeptide binding]; other site 682795004207 Protein of unknown function (DUF497); Region: DUF497; pfam04365 682795004208 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 682795004209 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 682795004210 DNA binding residues [nucleotide binding] 682795004211 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 682795004212 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 682795004213 ligand binding site; other site 682795004214 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 682795004215 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 682795004216 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 682795004217 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 682795004218 exopolyphosphatase; Region: exo_poly_only; TIGR03706 682795004219 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795004220 nucleotide binding site [chemical binding]; other site 682795004221 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 682795004222 catalytic core [active] 682795004223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 682795004224 Transposase; Region: DEDD_Tnp_IS110; pfam01548 682795004225 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 682795004226 Uncharacterized conserved protein [Function unknown]; Region: COG1543 682795004227 N-terminal catalytic domain of Gh57 branching enzyme TK 1436 and similar proteins; Region: GH57N_BE_TK1436_like; cd10816 682795004228 active site 682795004229 substrate binding site [chemical binding]; other site 682795004230 catalytic site [active] 682795004231 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 682795004232 periplasmic protein; Provisional; Region: PRK10568 682795004233 YtxH-like protein; Region: YtxH; pfam12732 682795004234 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 682795004235 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 682795004236 Ligand Binding Site [chemical binding]; other site 682795004237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795004238 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 682795004239 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 682795004240 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 682795004241 Protein of unknown function DUF72; Region: DUF72; pfam01904 682795004242 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 682795004243 TPR repeat; Region: TPR_11; pfam13414 682795004244 CHAT domain; Region: CHAT; pfam12770 682795004245 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795004246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795004247 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 682795004248 active site 682795004249 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795004250 Ca binding site [ion binding]; other site 682795004251 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 682795004252 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 682795004253 active site 682795004254 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 682795004255 active site 682795004256 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 682795004257 CHY zinc finger; Region: zf-CHY; pfam05495 682795004258 methionine sulfoxide reductase B; Provisional; Region: PRK00222 682795004259 SelR domain; Region: SelR; pfam01641 682795004260 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 682795004261 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 682795004262 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 682795004263 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795004264 catalytic residues [active] 682795004265 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 682795004266 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 682795004267 Cupin domain; Region: Cupin_2; pfam07883 682795004268 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 682795004269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004270 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795004271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004272 RDD family; Region: RDD; pfam06271 682795004273 Integral membrane protein DUF95; Region: DUF95; cl00572 682795004274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795004275 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 682795004276 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795004277 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 682795004278 Protein of unknown function DUF58; Region: DUF58; pfam01882 682795004279 von Willebrand factor type A domain; Region: VWA_2; pfam13519 682795004280 MoxR-like ATPases [General function prediction only]; Region: COG0714 682795004281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795004282 Walker A motif; other site 682795004283 ATP binding site [chemical binding]; other site 682795004284 Walker B motif; other site 682795004285 arginine finger; other site 682795004286 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 682795004287 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 682795004288 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 682795004289 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 682795004290 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 682795004291 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 682795004292 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 682795004293 SLBB domain; Region: SLBB; pfam10531 682795004294 SLBB domain; Region: SLBB; pfam10531 682795004295 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 682795004296 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 682795004297 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 682795004298 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 682795004299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795004300 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 682795004301 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 682795004302 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 682795004303 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 682795004304 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 682795004305 putative active site [active] 682795004306 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 682795004307 active site 682795004308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795004309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 682795004310 putative substrate translocation pore; other site 682795004311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795004312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 682795004313 putative substrate translocation pore; other site 682795004314 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 682795004315 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 682795004316 putative active site [active] 682795004317 catalytic site [active] 682795004318 putative metal binding site [ion binding]; other site 682795004319 oligomer interface [polypeptide binding]; other site 682795004320 HEAT repeats; Region: HEAT_2; pfam13646 682795004321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795004322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795004323 active site 682795004324 phosphorylation site [posttranslational modification] 682795004325 intermolecular recognition site; other site 682795004326 dimerization interface [polypeptide binding]; other site 682795004327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795004328 DNA binding site [nucleotide binding] 682795004329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 682795004330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 682795004331 dimerization interface [polypeptide binding]; other site 682795004332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795004333 dimer interface [polypeptide binding]; other site 682795004334 phosphorylation site [posttranslational modification] 682795004335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795004336 ATP binding site [chemical binding]; other site 682795004337 Mg2+ binding site [ion binding]; other site 682795004338 G-X-G motif; other site 682795004339 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 682795004340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 682795004341 mercuric reductase; Validated; Region: PRK06370 682795004342 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 682795004343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795004344 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 682795004345 Predicted membrane protein [Function unknown]; Region: COG3918 682795004346 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 682795004347 Na binding site [ion binding]; other site 682795004348 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 682795004349 Beta-lactamase; Region: Beta-lactamase; pfam00144 682795004350 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 682795004351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795004352 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 682795004353 active site 682795004354 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 682795004355 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 682795004356 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 682795004357 active site 682795004358 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 682795004359 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 682795004360 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 682795004361 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 682795004362 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 682795004363 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 682795004364 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 682795004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 682795004366 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 682795004367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795004368 FeS/SAM binding site; other site 682795004369 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 682795004370 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 682795004371 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 682795004372 putative substrate binding pocket [chemical binding]; other site 682795004373 dimer interface [polypeptide binding]; other site 682795004374 phosphate binding site [ion binding]; other site 682795004375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795004376 binding surface 682795004377 TPR motif; other site 682795004378 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795004379 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 682795004380 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 682795004381 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 682795004382 putative active site [active] 682795004383 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 682795004384 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 682795004385 putative ribose interaction site [chemical binding]; other site 682795004386 putative ADP binding site [chemical binding]; other site 682795004387 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 682795004388 active site 682795004389 nucleotide binding site [chemical binding]; other site 682795004390 HIGH motif; other site 682795004391 KMSKS motif; other site 682795004392 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 682795004393 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 682795004394 Cytochrome P450; Region: p450; cl12078 682795004395 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 682795004396 Helix-turn-helix domain; Region: HTH_17; cl17695 682795004397 Helix-turn-helix domain; Region: HTH_17; pfam12728 682795004398 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 682795004399 Helix-turn-helix domain; Region: HTH_17; pfam12728 682795004400 RHS Repeat; Region: RHS_repeat; pfam05593 682795004401 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 682795004402 Transposase IS200 like; Region: Y1_Tnp; cl00848 682795004403 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 682795004404 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 682795004405 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 682795004406 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 682795004407 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 682795004408 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 682795004409 active site 682795004410 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 682795004411 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 682795004412 conserved cys residue [active] 682795004413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004415 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 682795004416 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 682795004417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795004418 NAD(P) binding site [chemical binding]; other site 682795004419 active site 682795004420 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 682795004421 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 682795004422 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 682795004423 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 682795004424 active site 682795004425 HIGH motif; other site 682795004426 nucleotide binding site [chemical binding]; other site 682795004427 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 682795004428 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 682795004429 tRNA binding surface [nucleotide binding]; other site 682795004430 anticodon binding site; other site 682795004431 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 682795004432 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 682795004433 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 682795004434 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 682795004435 multifunctional aminopeptidase A; Provisional; Region: PRK00913 682795004436 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 682795004437 interface (dimer of trimers) [polypeptide binding]; other site 682795004438 Substrate-binding/catalytic site; other site 682795004439 Zn-binding sites [ion binding]; other site 682795004440 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 682795004441 SmpB-tmRNA interface; other site 682795004442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795004443 TPR repeat; Region: TPR_11; pfam13414 682795004444 binding surface 682795004445 TPR motif; other site 682795004446 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 682795004447 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 682795004448 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 682795004449 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 682795004450 dockerin binding interface; other site 682795004451 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 682795004452 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 682795004453 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 682795004454 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 682795004455 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 682795004456 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 682795004457 Peptidase family M48; Region: Peptidase_M48; pfam01435 682795004458 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 682795004459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795004460 putative substrate translocation pore; other site 682795004461 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 682795004462 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 682795004463 DXD motif; other site 682795004464 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 682795004465 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 682795004466 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 682795004467 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795004468 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 682795004469 Sulfatase; Region: Sulfatase; cl17466 682795004470 precorrin-3B synthase; Region: CobG; TIGR02435 682795004471 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 682795004472 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 682795004473 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 682795004474 Precorrin-8X methylmutase; Region: CbiC; pfam02570 682795004475 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 682795004476 active site 682795004477 SAM binding site [chemical binding]; other site 682795004478 homodimer interface [polypeptide binding]; other site 682795004479 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 682795004480 active site 682795004481 SAM binding site [chemical binding]; other site 682795004482 homodimer interface [polypeptide binding]; other site 682795004483 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 682795004484 active site 682795004485 putative homodimer interface [polypeptide binding]; other site 682795004486 SAM binding site [chemical binding]; other site 682795004487 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 682795004488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795004489 S-adenosylmethionine binding site [chemical binding]; other site 682795004490 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 682795004491 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 682795004492 active site 682795004493 SAM binding site [chemical binding]; other site 682795004494 homodimer interface [polypeptide binding]; other site 682795004495 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 682795004496 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 682795004497 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 682795004498 active site 682795004499 SAM binding site [chemical binding]; other site 682795004500 homodimer interface [polypeptide binding]; other site 682795004501 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 682795004502 putative efflux protein, MATE family; Region: matE; TIGR00797 682795004503 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795004504 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795004505 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795004506 active site 682795004507 DNA binding site [nucleotide binding] 682795004508 Int/Topo IB signature motif; other site 682795004509 Helix-turn-helix domain; Region: HTH_17; cl17695 682795004510 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 682795004511 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 682795004512 HNH endonuclease; Region: HNH_3; pfam13392 682795004513 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795004514 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 682795004515 DNA binding residues [nucleotide binding] 682795004516 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 682795004517 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 682795004518 active site 682795004519 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 682795004520 active site 682795004521 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 682795004522 Phage terminase, small subunit; Region: Terminase_4; cl01525 682795004523 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 682795004524 Phage-related protein [Function unknown]; Region: COG4695 682795004525 Phage portal protein; Region: Phage_portal; pfam04860 682795004526 Phage head maturation protease [General function prediction only]; Region: COG3740 682795004527 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 682795004528 Phage capsid family; Region: Phage_capsid; pfam05065 682795004529 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 682795004530 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 682795004531 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 682795004532 oligomerization interface [polypeptide binding]; other site 682795004533 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 682795004534 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 682795004535 Phage major tail protein 2; Region: Phage_tail_2; cl11463 682795004536 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 682795004537 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 682795004538 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 682795004539 GIY-YIG motif/motif A; other site 682795004540 putative active site [active] 682795004541 putative metal binding site [ion binding]; other site 682795004542 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 682795004543 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 682795004544 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 682795004545 Interdomain contacts; other site 682795004546 Cytokine receptor motif; other site 682795004547 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 682795004548 catalytic residues [active] 682795004549 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 682795004550 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 682795004551 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 682795004552 Ligand binding site; other site 682795004553 Putative Catalytic site; other site 682795004554 DXD motif; other site 682795004555 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 682795004556 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795004557 active site 682795004558 metal binding site [ion binding]; metal-binding site 682795004559 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 682795004560 B12 binding site [chemical binding]; other site 682795004561 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 682795004562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795004563 FeS/SAM binding site; other site 682795004564 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795004565 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795004566 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795004567 von Willebrand factor type A domain; Region: VWA_2; pfam13519 682795004568 arginine decarboxylase; Provisional; Region: PRK15029 682795004569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795004570 phosphorylation site [posttranslational modification] 682795004571 intermolecular recognition site; other site 682795004572 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 682795004573 homodimer interface [polypeptide binding]; other site 682795004574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795004575 catalytic residue [active] 682795004576 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 682795004577 Inner membrane protein CreD; Region: CreD; cl01844 682795004578 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 682795004579 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 682795004580 ring oligomerisation interface [polypeptide binding]; other site 682795004581 ATP/Mg binding site [chemical binding]; other site 682795004582 stacking interactions; other site 682795004583 hinge regions; other site 682795004584 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 682795004585 oligomerisation interface [polypeptide binding]; other site 682795004586 mobile loop; other site 682795004587 roof hairpin; other site 682795004588 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 682795004589 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 682795004590 classical (c) SDRs; Region: SDR_c; cd05233 682795004591 NAD(P) binding site [chemical binding]; other site 682795004592 active site 682795004593 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 682795004594 Cytochrome P450; Region: p450; cl12078 682795004595 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 682795004596 Uncharacterized conserved protein [Function unknown]; Region: COG3472 682795004597 Response regulator receiver domain; Region: Response_reg; pfam00072 682795004598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795004599 active site 682795004600 phosphorylation site [posttranslational modification] 682795004601 intermolecular recognition site; other site 682795004602 dimerization interface [polypeptide binding]; other site 682795004603 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 682795004604 putative metal binding site; other site 682795004605 putative acyl transferase; Provisional; Region: PRK10502 682795004606 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 682795004607 putative trimer interface [polypeptide binding]; other site 682795004608 putative active site [active] 682795004609 putative substrate binding site [chemical binding]; other site 682795004610 putative CoA binding site [chemical binding]; other site 682795004611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795004612 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 682795004613 putative ADP-binding pocket [chemical binding]; other site 682795004614 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795004615 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795004616 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 682795004617 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 682795004618 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 682795004619 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 682795004620 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795004621 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 682795004622 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 682795004623 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 682795004624 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 682795004625 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 682795004626 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795004627 NAD binding site [chemical binding]; other site 682795004628 putative substrate binding site 2 [chemical binding]; other site 682795004629 putative substrate binding site 1 [chemical binding]; other site 682795004630 active site 682795004631 Alginate lyase; Region: Alginate_lyase2; pfam08787 682795004632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795004634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004635 Condensation domain; Region: Condensation; pfam00668 682795004636 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 682795004637 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 682795004638 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 682795004639 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 682795004640 dimer interface [polypeptide binding]; other site 682795004641 TPP-binding site [chemical binding]; other site 682795004642 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 682795004643 heterotetramer interface [polypeptide binding]; other site 682795004644 active site pocket [active] 682795004645 cleavage site 682795004646 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 682795004647 ThiC family; Region: ThiC; pfam01964 682795004648 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795004649 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795004650 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 682795004651 apical/protease domain interface [polypeptide binding]; other site 682795004652 substrate binding [chemical binding]; other site 682795004653 dimer interface [polypeptide binding]; other site 682795004654 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 682795004655 dimer interface [polypeptide binding]; other site 682795004656 Peptidase family M28; Region: Peptidase_M28; pfam04389 682795004657 active site 682795004658 metal binding site [ion binding]; metal-binding site 682795004659 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 682795004660 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 682795004661 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 682795004662 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 682795004663 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 682795004664 MoaE interaction surface [polypeptide binding]; other site 682795004665 MoeB interaction surface [polypeptide binding]; other site 682795004666 thiocarboxylated glycine; other site 682795004667 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 682795004668 MoaE homodimer interface [polypeptide binding]; other site 682795004669 MoaD interaction [polypeptide binding]; other site 682795004670 active site residues [active] 682795004671 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795004672 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795004673 metal ion-dependent adhesion site (MIDAS); other site 682795004674 Sm and related proteins; Region: Sm_like; cl00259 682795004675 heptamer interface [polypeptide binding]; other site 682795004676 Sm1 motif; other site 682795004677 hexamer interface [polypeptide binding]; other site 682795004678 RNA binding site [nucleotide binding]; other site 682795004679 Sm2 motif; other site 682795004680 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 682795004681 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 682795004682 active site 682795004683 dimerization interface [polypeptide binding]; other site 682795004684 Ferredoxin [Energy production and conversion]; Region: COG1146 682795004685 4Fe-4S binding domain; Region: Fer4; cl02805 682795004686 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 682795004687 Recombination protein O N terminal; Region: RecO_N; pfam11967 682795004688 Recombination protein O C terminal; Region: RecO_C; pfam02565 682795004689 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 682795004690 RNAase interaction site [polypeptide binding]; other site 682795004691 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 682795004692 motif 1; other site 682795004693 dimer interface [polypeptide binding]; other site 682795004694 active site 682795004695 motif 2; other site 682795004696 motif 3; other site 682795004697 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 682795004698 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 682795004699 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 682795004700 putative heme binding pocket [chemical binding]; other site 682795004701 OstA-like protein; Region: OstA; cl00844 682795004702 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 682795004703 OstA-like protein; Region: OstA; cl00844 682795004704 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 682795004705 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 682795004706 Walker A/P-loop; other site 682795004707 ATP binding site [chemical binding]; other site 682795004708 Q-loop/lid; other site 682795004709 ABC transporter signature motif; other site 682795004710 Walker B; other site 682795004711 D-loop; other site 682795004712 H-loop/switch region; other site 682795004713 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 682795004714 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 682795004715 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 682795004716 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 682795004717 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 682795004718 30S subunit binding site; other site 682795004719 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 682795004720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 682795004721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 682795004722 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 682795004723 Walker A/P-loop; other site 682795004724 ATP binding site [chemical binding]; other site 682795004725 Q-loop/lid; other site 682795004726 ABC transporter signature motif; other site 682795004727 Walker B; other site 682795004728 D-loop; other site 682795004729 H-loop/switch region; other site 682795004730 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 682795004731 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 682795004732 catalytic site [active] 682795004733 G-X2-G-X-G-K; other site 682795004734 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 682795004735 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 682795004736 Fe-S cluster binding site [ion binding]; other site 682795004737 active site 682795004738 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 682795004739 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 682795004740 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795004741 peptidase domain interface [polypeptide binding]; other site 682795004742 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795004743 active site 682795004744 catalytic triad [active] 682795004745 calcium binding site [ion binding]; other site 682795004746 Family description; Region: VCBS; pfam13517 682795004747 Family description; Region: VCBS; pfam13517 682795004748 Family description; Region: VCBS; pfam13517 682795004749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795004750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795004751 DNA binding site [nucleotide binding] 682795004752 TPR repeat; Region: TPR_11; pfam13414 682795004753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795004754 TPR motif; other site 682795004755 binding surface 682795004756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 682795004757 TPR motif; other site 682795004758 binding surface 682795004759 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 682795004760 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 682795004761 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 682795004762 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 682795004763 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795004764 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 682795004765 active site 682795004766 Zn binding site [ion binding]; other site 682795004767 Transcriptional regulators [Transcription]; Region: GntR; COG1802 682795004768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795004769 DNA-binding site [nucleotide binding]; DNA binding site 682795004770 FCD domain; Region: FCD; pfam07729 682795004771 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795004772 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 682795004773 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795004774 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 682795004775 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 682795004776 structural tetrad; other site 682795004777 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 682795004778 Catalytic domain of Protein Kinases; Region: PKc; cd00180 682795004779 active site 682795004780 ATP binding site [chemical binding]; other site 682795004781 substrate binding site [chemical binding]; other site 682795004782 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 682795004783 substrate binding site [chemical binding]; other site 682795004784 activation loop (A-loop); other site 682795004785 activation loop (A-loop); other site 682795004786 PEGA domain; Region: PEGA; pfam08308 682795004787 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 682795004788 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 682795004789 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 682795004790 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 682795004791 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 682795004792 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 682795004793 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 682795004794 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 682795004795 hydrogenase membrane subunit; Validated; Region: PRK08667 682795004796 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 682795004797 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795004798 active site 682795004799 metal binding site [ion binding]; metal-binding site 682795004800 Prokaryotic RING finger family 2; Region: Prok-RING_2; pfam14445 682795004801 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 682795004802 ATP binding site [chemical binding]; other site 682795004803 substrate interface [chemical binding]; other site 682795004804 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 682795004805 phosphopeptide binding site; other site 682795004806 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795004807 metal ion-dependent adhesion site (MIDAS); other site 682795004808 Protein of unknown function (DUF770); Region: DUF770; cl01402 682795004809 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 682795004810 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 682795004811 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 682795004812 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 682795004813 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 682795004814 phosphopeptide binding site; other site 682795004815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004816 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795004817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004818 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795004819 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795004820 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795004821 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 682795004822 active site 682795004823 Glyco_18 domain; Region: Glyco_18; smart00636 682795004824 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 682795004825 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 682795004826 inhibitor-cofactor binding pocket; inhibition site 682795004827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795004828 catalytic residue [active] 682795004829 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 682795004830 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 682795004831 tetrameric interface [polypeptide binding]; other site 682795004832 NAD binding site [chemical binding]; other site 682795004833 catalytic residues [active] 682795004834 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 682795004835 FAD binding domain; Region: FAD_binding_4; pfam01565 682795004836 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 682795004837 Cysteine-rich domain; Region: CCG; pfam02754 682795004838 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 682795004839 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 682795004840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795004841 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 682795004842 dimerization interface [polypeptide binding]; other site 682795004843 substrate binding pocket [chemical binding]; other site 682795004844 Arginine repressor [Transcription]; Region: ArgR; COG1438 682795004845 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 682795004846 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 682795004847 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 682795004848 Amidinotransferase; Region: Amidinotransf; cl12043 682795004849 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 682795004850 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 682795004851 inhibitor-cofactor binding pocket; inhibition site 682795004852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795004853 catalytic residue [active] 682795004854 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 682795004855 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 682795004856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795004857 putative DNA binding site [nucleotide binding]; other site 682795004858 putative Zn2+ binding site [ion binding]; other site 682795004859 AsnC family; Region: AsnC_trans_reg; pfam01037 682795004860 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 682795004861 active sites [active] 682795004862 tetramer interface [polypeptide binding]; other site 682795004863 urocanate hydratase; Provisional; Region: PRK05414 682795004864 imidazolonepropionase; Validated; Region: PRK09356 682795004865 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795004866 active site 682795004867 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 682795004868 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795004869 active site 682795004870 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 682795004871 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795004872 metal binding site [ion binding]; metal-binding site 682795004873 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 682795004874 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 682795004875 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 682795004876 peptide synthase; Provisional; Region: PRK12316 682795004877 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795004878 acyl-activating enzyme (AAE) consensus motif; other site 682795004879 AMP binding site [chemical binding]; other site 682795004880 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795004881 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 682795004882 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795004883 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795004884 acyl-activating enzyme (AAE) consensus motif; other site 682795004885 AMP binding site [chemical binding]; other site 682795004886 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795004887 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795004888 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795004889 acyl-activating enzyme (AAE) consensus motif; other site 682795004890 AMP binding site [chemical binding]; other site 682795004891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795004892 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 682795004893 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795004894 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795004895 acyl-activating enzyme (AAE) consensus motif; other site 682795004896 AMP binding site [chemical binding]; other site 682795004897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795004898 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 682795004899 MbtH-like protein; Region: MbtH; cl01279 682795004900 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795004901 Domain of unknown function (DU1801); Region: DUF1801; cl17490 682795004902 Creatinine amidohydrolase; Region: Creatininase; pfam02633 682795004903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 682795004904 Transposase; Region: DEDD_Tnp_IS110; pfam01548 682795004905 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 682795004906 Cupin-like domain; Region: Cupin_8; pfam13621 682795004907 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 682795004908 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 682795004909 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 682795004910 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 682795004911 short chain dehydrogenase; Provisional; Region: PRK07454 682795004912 NADP binding site [chemical binding]; other site 682795004913 substrate binding site [chemical binding]; other site 682795004914 active site 682795004915 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795004916 Amidase; Region: Amidase; cl11426 682795004917 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795004918 FAD binding domain; Region: FAD_binding_3; pfam01494 682795004919 hypothetical protein; Provisional; Region: PRK07236 682795004920 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 682795004921 hypothetical protein; Provisional; Region: PRK06834 682795004922 hydroxyglutarate oxidase; Provisional; Region: PRK11728 682795004923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795004924 DinB family; Region: DinB; cl17821 682795004925 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 682795004926 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795004927 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 682795004928 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 682795004929 Domain interface; other site 682795004930 Peptide binding site; other site 682795004931 Active site tetrad [active] 682795004932 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 682795004933 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 682795004934 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 682795004935 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 682795004936 RibD C-terminal domain; Region: RibD_C; cl17279 682795004937 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 682795004938 short chain dehydrogenase; Provisional; Region: PRK06500 682795004939 classical (c) SDRs; Region: SDR_c; cd05233 682795004940 NAD(P) binding site [chemical binding]; other site 682795004941 active site 682795004942 Cupin; Region: Cupin_6; pfam12852 682795004943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004944 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795004945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795004946 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795004947 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795004948 active site 682795004949 catalytic tetrad [active] 682795004950 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 682795004951 Helix-turn-helix domain; Region: HTH_38; pfam13936 682795004952 Integrase core domain; Region: rve; pfam00665 682795004953 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 682795004954 C-terminal peptidase (prc); Region: prc; TIGR00225 682795004955 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 682795004956 protein binding site [polypeptide binding]; other site 682795004957 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 682795004958 Catalytic dyad [active] 682795004959 SurA N-terminal domain; Region: SurA_N; pfam09312 682795004960 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 682795004961 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 682795004962 generic binding surface I; other site 682795004963 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 682795004964 generic binding surface II; other site 682795004965 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 682795004966 Zn2+ binding site [ion binding]; other site 682795004967 Mg2+ binding site [ion binding]; other site 682795004968 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 682795004969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795004970 DNA-binding site [nucleotide binding]; DNA binding site 682795004971 UTRA domain; Region: UTRA; pfam07702 682795004972 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795004973 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795004974 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795004975 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795004976 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795004977 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795004978 DNA binding site [nucleotide binding] 682795004979 domain linker motif; other site 682795004980 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795004981 dimerization interface [polypeptide binding]; other site 682795004982 ligand binding site [chemical binding]; other site 682795004983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 682795004984 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 682795004985 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 682795004986 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 682795004987 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 682795004988 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 682795004989 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 682795004990 Tetramer interface [polypeptide binding]; other site 682795004991 active site 682795004992 FMN-binding site [chemical binding]; other site 682795004993 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 682795004994 active site 682795004995 catalytic residues [active] 682795004996 metal binding site [ion binding]; metal-binding site 682795004997 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 682795004998 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 682795004999 putative active site [active] 682795005000 substrate binding site [chemical binding]; other site 682795005001 putative cosubstrate binding site; other site 682795005002 catalytic site [active] 682795005003 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 682795005004 substrate binding site [chemical binding]; other site 682795005005 16S rRNA methyltransferase B; Provisional; Region: PRK14901 682795005006 NusB family; Region: NusB; pfam01029 682795005007 putative RNA binding site [nucleotide binding]; other site 682795005008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795005009 S-adenosylmethionine binding site [chemical binding]; other site 682795005010 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005011 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 682795005012 PASTA domain; Region: PASTA; smart00740 682795005013 Cation efflux family; Region: Cation_efflux; pfam01545 682795005014 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 682795005015 Cation efflux family; Region: Cation_efflux; cl00316 682795005016 Cation efflux family; Region: Cation_efflux; cl00316 682795005017 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 682795005018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795005019 S-adenosylmethionine binding site [chemical binding]; other site 682795005020 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 682795005021 active site 682795005022 dimer interface [polypeptide binding]; other site 682795005023 metal binding site [ion binding]; metal-binding site 682795005024 Integral membrane protein TerC family; Region: TerC; cl10468 682795005025 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795005026 Peptidase family M28; Region: Peptidase_M28; pfam04389 682795005027 metal binding site [ion binding]; metal-binding site 682795005028 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 682795005029 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 682795005030 6-phosphogluconolactonase; Provisional; Region: PRK11028 682795005031 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 682795005032 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 682795005033 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 682795005034 inhibitor-cofactor binding pocket; inhibition site 682795005035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795005036 catalytic residue [active] 682795005037 bacterial Hfq-like; Region: Hfq; cd01716 682795005038 hexamer interface [polypeptide binding]; other site 682795005039 Sm1 motif; other site 682795005040 RNA binding site [nucleotide binding]; other site 682795005041 Sm2 motif; other site 682795005042 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 682795005043 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 682795005044 HflX GTPase family; Region: HflX; cd01878 682795005045 G1 box; other site 682795005046 GTP/Mg2+ binding site [chemical binding]; other site 682795005047 Switch I region; other site 682795005048 G2 box; other site 682795005049 G3 box; other site 682795005050 Switch II region; other site 682795005051 G4 box; other site 682795005052 G5 box; other site 682795005053 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 682795005054 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 682795005055 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 682795005056 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 682795005057 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 682795005058 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 682795005059 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 682795005060 beta subunit interaction interface [polypeptide binding]; other site 682795005061 Walker A motif; other site 682795005062 ATP binding site [chemical binding]; other site 682795005063 Walker B motif; other site 682795005064 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 682795005065 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 682795005066 core domain interface [polypeptide binding]; other site 682795005067 delta subunit interface [polypeptide binding]; other site 682795005068 epsilon subunit interface [polypeptide binding]; other site 682795005069 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 682795005070 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 682795005071 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 682795005072 alpha subunit interaction interface [polypeptide binding]; other site 682795005073 Walker A motif; other site 682795005074 ATP binding site [chemical binding]; other site 682795005075 Walker B motif; other site 682795005076 inhibitor binding site; inhibition site 682795005077 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 682795005078 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 682795005079 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 682795005080 gamma subunit interface [polypeptide binding]; other site 682795005081 epsilon subunit interface [polypeptide binding]; other site 682795005082 LBP interface [polypeptide binding]; other site 682795005083 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 682795005084 CAAX protease self-immunity; Region: Abi; pfam02517 682795005085 Predicted transcriptional regulators [Transcription]; Region: COG1510 682795005086 short chain dehydrogenase; Provisional; Region: PRK06914 682795005087 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 682795005088 NADP binding site [chemical binding]; other site 682795005089 active site 682795005090 steroid binding site; other site 682795005091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795005092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795005093 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 682795005094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795005095 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 682795005096 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795005097 catalytic residues [active] 682795005098 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 682795005099 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005100 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005101 active site 682795005102 SnoaL-like domain; Region: SnoaL_3; pfam13474 682795005103 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 682795005104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795005105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 682795005106 ligand binding site [chemical binding]; other site 682795005107 flexible hinge region; other site 682795005108 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 682795005109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 682795005110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795005111 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 682795005112 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 682795005113 Adenylation domain of ATP-dependent DNA Ligases; Region: Adenylation_DNA_ligase; cd07898 682795005114 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 682795005115 active site 682795005116 DNA binding site [nucleotide binding] 682795005117 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 682795005118 DNA binding site [nucleotide binding] 682795005119 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795005120 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 682795005121 active site 682795005122 metal binding site [ion binding]; metal-binding site 682795005123 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 682795005124 active site 682795005125 metal binding site [ion binding]; metal-binding site 682795005126 Cupin domain; Region: Cupin_2; cl17218 682795005127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795005128 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795005129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795005130 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 682795005131 Beta-lactamase; Region: Beta-lactamase; pfam00144 682795005132 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 682795005133 DNA methylase; Region: N6_N4_Mtase; pfam01555 682795005134 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 682795005135 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 682795005136 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 682795005137 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 682795005138 putative active site [active] 682795005139 putative catalytic site [active] 682795005140 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 682795005141 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 682795005142 Rhomboid family; Region: Rhomboid; pfam01694 682795005143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 682795005144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795005145 non-specific DNA binding site [nucleotide binding]; other site 682795005146 salt bridge; other site 682795005147 sequence-specific DNA binding site [nucleotide binding]; other site 682795005148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795005149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795005150 NAD(P) binding site [chemical binding]; other site 682795005151 active site 682795005152 Thymidylate synthase complementing protein; Region: Thy1; cl03630 682795005153 Thymidylate synthase complementing protein; Region: Thy1; cl03630 682795005154 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 682795005155 recombinase A; Provisional; Region: recA; PRK09354 682795005156 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 682795005157 hexamer interface [polypeptide binding]; other site 682795005158 Walker A motif; other site 682795005159 ATP binding site [chemical binding]; other site 682795005160 Walker B motif; other site 682795005161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795005162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795005163 DNA binding site [nucleotide binding] 682795005164 Tetratricopeptide repeat; Region: TPR_12; pfam13424 682795005165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005166 binding surface 682795005167 TPR motif; other site 682795005168 TPR repeat; Region: TPR_11; pfam13414 682795005169 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 682795005170 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795005171 peptidase domain interface [polypeptide binding]; other site 682795005172 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 682795005173 active site 682795005174 catalytic residues [active] 682795005175 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 682795005176 catalytic residues [active] 682795005177 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795005178 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 682795005179 ligand binding site [chemical binding]; other site 682795005180 flexible hinge region; other site 682795005181 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 682795005182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 682795005183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795005184 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 682795005185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 682795005186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795005187 Coenzyme A binding pocket [chemical binding]; other site 682795005188 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 682795005189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795005190 DNA binding residues [nucleotide binding] 682795005191 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 682795005192 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 682795005193 putative active site [active] 682795005194 excinuclease ABC subunit B; Provisional; Region: PRK05298 682795005195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795005196 ATP binding site [chemical binding]; other site 682795005197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 682795005198 nucleotide binding region [chemical binding]; other site 682795005199 ATP-binding site [chemical binding]; other site 682795005200 Ultra-violet resistance protein B; Region: UvrB; pfam12344 682795005201 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 682795005202 catalytic core [active] 682795005203 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 682795005204 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 682795005205 Walker A/P-loop; other site 682795005206 ATP binding site [chemical binding]; other site 682795005207 Q-loop/lid; other site 682795005208 ABC transporter signature motif; other site 682795005209 Walker B; other site 682795005210 D-loop; other site 682795005211 H-loop/switch region; other site 682795005212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 682795005213 argininosuccinate lyase; Provisional; Region: PRK00855 682795005214 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 682795005215 active sites [active] 682795005216 tetramer interface [polypeptide binding]; other site 682795005217 argininosuccinate synthase; Validated; Region: PRK05370 682795005218 argininosuccinate synthase; Provisional; Region: PRK13820 682795005219 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 682795005220 ornithine carbamoyltransferase; Provisional; Region: PRK00779 682795005221 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 682795005222 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 682795005223 acetylornithine aminotransferase; Provisional; Region: PRK02627 682795005224 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 682795005225 inhibitor-cofactor binding pocket; inhibition site 682795005226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795005227 catalytic residue [active] 682795005228 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 682795005229 nucleotide binding site [chemical binding]; other site 682795005230 N-acetyl-L-glutamate binding site [chemical binding]; other site 682795005231 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 682795005232 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 682795005233 Arginine repressor [Transcription]; Region: ArgR; COG1438 682795005234 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 682795005235 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 682795005236 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 682795005237 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 682795005238 active site 682795005239 dimer interface [polypeptide binding]; other site 682795005240 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 682795005241 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 682795005242 active site 682795005243 FMN binding site [chemical binding]; other site 682795005244 substrate binding site [chemical binding]; other site 682795005245 3Fe-4S cluster binding site [ion binding]; other site 682795005246 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 682795005247 domain_subunit interface; other site 682795005248 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 682795005249 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 682795005250 homodimer interface [polypeptide binding]; other site 682795005251 substrate-cofactor binding pocket; other site 682795005252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795005253 catalytic residue [active] 682795005254 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 682795005255 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 682795005256 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 682795005257 FAD binding site [chemical binding]; other site 682795005258 homotetramer interface [polypeptide binding]; other site 682795005259 substrate binding pocket [chemical binding]; other site 682795005260 catalytic base [active] 682795005261 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 682795005262 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 682795005263 active site 682795005264 (T/H)XGH motif; other site 682795005265 Methyltransferase domain; Region: Methyltransf_31; pfam13847 682795005266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795005267 S-adenosylmethionine binding site [chemical binding]; other site 682795005268 aspartate aminotransferase; Provisional; Region: PRK05764 682795005269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795005270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795005271 homodimer interface [polypeptide binding]; other site 682795005272 catalytic residue [active] 682795005273 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 682795005274 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 682795005275 Substrate binding site; other site 682795005276 Cupin domain; Region: Cupin_2; cl17218 682795005277 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 682795005278 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 682795005279 active site 682795005280 substrate binding site [chemical binding]; other site 682795005281 metal binding site [ion binding]; metal-binding site 682795005282 putative phosphatase; Provisional; Region: PRK11587 682795005283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795005284 motif II; other site 682795005285 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005286 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 682795005287 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 682795005288 Ligand binding site; other site 682795005289 oligomer interface; other site 682795005290 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 682795005291 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 682795005292 protein binding site [polypeptide binding]; other site 682795005293 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 682795005294 Catalytic dyad [active] 682795005295 Transglycosylase; Region: Transgly; pfam00912 682795005296 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 682795005297 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 682795005298 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 682795005299 active site 682795005300 Riboflavin kinase; Region: Flavokinase; pfam01687 682795005301 putative hydrolase; Provisional; Region: PRK02113 682795005302 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 682795005303 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 682795005304 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 682795005305 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 682795005306 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 682795005307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005308 binding surface 682795005309 TPR motif; other site 682795005310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005311 binding surface 682795005312 TPR repeat; Region: TPR_11; pfam13414 682795005313 TPR motif; other site 682795005314 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795005315 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795005316 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795005317 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 682795005318 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795005319 dimerization interface [polypeptide binding]; other site 682795005320 putative DNA binding site [nucleotide binding]; other site 682795005321 putative Zn2+ binding site [ion binding]; other site 682795005322 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 682795005323 4Fe-4S binding domain; Region: Fer4; pfam00037 682795005324 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 682795005325 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 682795005326 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 682795005327 putative deacylase active site [active] 682795005328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795005329 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 682795005330 Walker A/P-loop; other site 682795005331 ATP binding site [chemical binding]; other site 682795005332 Q-loop/lid; other site 682795005333 ABC transporter signature motif; other site 682795005334 Walker B; other site 682795005335 D-loop; other site 682795005336 H-loop/switch region; other site 682795005337 CcmE; Region: CcmE; cl00994 682795005338 putative oxidoreductase; Provisional; Region: PRK11579 682795005339 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795005340 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 682795005341 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 682795005342 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795005343 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 682795005344 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795005345 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 682795005346 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 682795005347 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795005348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 682795005349 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 682795005350 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 682795005351 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 682795005352 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 682795005353 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 682795005354 substrate binding site [chemical binding]; other site 682795005355 ATP binding site [chemical binding]; other site 682795005356 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 682795005357 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 682795005358 MgtC family; Region: MgtC; pfam02308 682795005359 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 682795005360 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 682795005361 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 682795005362 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 682795005363 dimer interface [polypeptide binding]; other site 682795005364 catalytic triad [active] 682795005365 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 682795005366 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 682795005367 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 682795005368 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 682795005369 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 682795005370 Leucine-rich repeats; other site 682795005371 Leucine rich repeat; Region: LRR_8; pfam13855 682795005372 Substrate binding site [chemical binding]; other site 682795005373 Leucine rich repeat; Region: LRR_8; pfam13855 682795005374 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 682795005375 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 682795005376 putative acyl-acceptor binding pocket; other site 682795005377 Sporulation related domain; Region: SPOR; pfam05036 682795005378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005379 binding surface 682795005380 TPR repeat; Region: TPR_11; pfam13414 682795005381 TPR motif; other site 682795005382 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 682795005383 putative active site [active] 682795005384 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 682795005385 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 682795005386 hinge; other site 682795005387 active site 682795005388 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 682795005389 Trp docking motif [polypeptide binding]; other site 682795005390 putative active site [active] 682795005391 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 682795005392 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 682795005393 putative active site [active] 682795005394 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 682795005395 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 682795005396 purine monophosphate binding site [chemical binding]; other site 682795005397 dimer interface [polypeptide binding]; other site 682795005398 putative catalytic residues [active] 682795005399 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 682795005400 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 682795005401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005402 binding surface 682795005403 TPR motif; other site 682795005404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005405 binding surface 682795005406 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795005407 TPR motif; other site 682795005408 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795005409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005410 binding surface 682795005411 TPR motif; other site 682795005412 Tetratricopeptide repeat; Region: TPR_12; pfam13424 682795005413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005414 binding surface 682795005415 TPR motif; other site 682795005416 TPR repeat; Region: TPR_11; pfam13414 682795005417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005418 TPR motif; other site 682795005419 binding surface 682795005420 Tetratricopeptide repeat; Region: TPR_12; pfam13424 682795005421 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 682795005422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 682795005423 Zn2+ binding site [ion binding]; other site 682795005424 Mg2+ binding site [ion binding]; other site 682795005425 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 682795005426 integron integrase; Region: integrase_gron; TIGR02249 682795005427 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795005428 active site 682795005429 DNA binding site [nucleotide binding] 682795005430 Int/Topo IB signature motif; other site 682795005431 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005432 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005433 Amidohydrolase; Region: Amidohydro_4; pfam13147 682795005434 active site 682795005435 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 682795005436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795005437 putative substrate translocation pore; other site 682795005438 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 682795005439 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 682795005440 MOFRL family; Region: MOFRL; pfam05161 682795005441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795005442 Walker A motif; other site 682795005443 ATP binding site [chemical binding]; other site 682795005444 Walker B motif; other site 682795005445 arginine finger; other site 682795005446 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 682795005447 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795005448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795005449 DNA binding site [nucleotide binding] 682795005450 Predicted transcriptional regulators [Transcription]; Region: COG1733 682795005451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795005452 putative DNA binding site [nucleotide binding]; other site 682795005453 putative Zn2+ binding site [ion binding]; other site 682795005454 short chain dehydrogenase; Provisional; Region: PRK12937 682795005455 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 682795005456 NADP binding site [chemical binding]; other site 682795005457 homodimer interface [polypeptide binding]; other site 682795005458 active site 682795005459 substrate binding site [chemical binding]; other site 682795005460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795005461 NAD(P) binding site [chemical binding]; other site 682795005462 active site 682795005463 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 682795005464 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 682795005465 FMN binding site [chemical binding]; other site 682795005466 active site 682795005467 substrate binding site [chemical binding]; other site 682795005468 catalytic residue [active] 682795005469 formate dehydrogenase; Provisional; Region: PRK07574 682795005470 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 682795005471 dimerization interface [polypeptide binding]; other site 682795005472 ligand binding site [chemical binding]; other site 682795005473 NAD binding site [chemical binding]; other site 682795005474 catalytic site [active] 682795005475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 682795005476 SnoaL-like domain; Region: SnoaL_2; pfam12680 682795005477 Isochorismatase family; Region: Isochorismatase; pfam00857 682795005478 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 682795005479 catalytic triad [active] 682795005480 dimer interface [polypeptide binding]; other site 682795005481 conserved cis-peptide bond; other site 682795005482 short chain dehydrogenase; Provisional; Region: PRK12829 682795005483 classical (c) SDRs; Region: SDR_c; cd05233 682795005484 NAD(P) binding site [chemical binding]; other site 682795005485 active site 682795005486 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795005487 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 682795005488 ligand binding site [chemical binding]; other site 682795005489 flexible hinge region; other site 682795005490 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 682795005491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 682795005492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795005493 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795005494 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 682795005495 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 682795005496 classical (c) SDRs; Region: SDR_c; cd05233 682795005497 NAD(P) binding site [chemical binding]; other site 682795005498 active site 682795005499 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 682795005500 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 682795005501 active site 682795005502 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 682795005503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005504 binding surface 682795005505 TPR motif; other site 682795005506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005507 TPR motif; other site 682795005508 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795005509 binding surface 682795005510 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 682795005511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005512 binding surface 682795005513 TPR motif; other site 682795005514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795005515 TPR motif; other site 682795005516 binding surface 682795005517 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 682795005518 endo-1,4-D-glucanase; Provisional; Region: PRK11097 682795005519 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 682795005520 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 682795005521 DXD motif; other site 682795005522 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 682795005523 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795005524 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 682795005525 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 682795005526 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 682795005527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795005528 dimer interface [polypeptide binding]; other site 682795005529 phosphorylation site [posttranslational modification] 682795005530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795005531 ATP binding site [chemical binding]; other site 682795005532 Mg2+ binding site [ion binding]; other site 682795005533 G-X-G motif; other site 682795005534 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 682795005535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795005536 active site 682795005537 phosphorylation site [posttranslational modification] 682795005538 intermolecular recognition site; other site 682795005539 dimerization interface [polypeptide binding]; other site 682795005540 Response regulator receiver domain; Region: Response_reg; pfam00072 682795005541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795005542 active site 682795005543 phosphorylation site [posttranslational modification] 682795005544 intermolecular recognition site; other site 682795005545 dimerization interface [polypeptide binding]; other site 682795005546 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 682795005547 putative binding surface; other site 682795005548 active site 682795005549 Response regulator receiver domain; Region: Response_reg; pfam00072 682795005550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795005551 active site 682795005552 phosphorylation site [posttranslational modification] 682795005553 intermolecular recognition site; other site 682795005554 dimerization interface [polypeptide binding]; other site 682795005555 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 682795005556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 682795005557 metal binding site [ion binding]; metal-binding site 682795005558 active site 682795005559 I-site; other site 682795005560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 682795005561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 682795005562 metal binding site [ion binding]; metal-binding site 682795005563 active site 682795005564 I-site; other site 682795005565 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 682795005566 Domain of unknown function DUF11; Region: DUF11; cl17728 682795005567 OsmC-like protein; Region: OsmC; cl00767 682795005568 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 682795005569 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 682795005570 DNA binding residues [nucleotide binding] 682795005571 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 682795005572 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 682795005573 active site 682795005574 ATP binding site [chemical binding]; other site 682795005575 substrate binding site [chemical binding]; other site 682795005576 activation loop (A-loop); other site 682795005577 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 682795005578 active site residue [active] 682795005579 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 682795005580 active site residue [active] 682795005581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795005582 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795005583 DNA binding residues [nucleotide binding] 682795005584 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 682795005585 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005586 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 682795005587 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795005588 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795005589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795005590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795005591 WHG domain; Region: WHG; pfam13305 682795005592 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795005593 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 682795005594 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 682795005595 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795005596 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 682795005597 dimer interface [polypeptide binding]; other site 682795005598 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 682795005599 Mechanosensitive ion channel; Region: MS_channel; pfam00924 682795005600 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795005601 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 682795005602 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 682795005603 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 682795005604 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795005605 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 682795005606 Zn2+ binding site [ion binding]; other site 682795005607 Mg2+ binding site [ion binding]; other site 682795005608 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 682795005609 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 682795005610 putative NAD(P) binding site [chemical binding]; other site 682795005611 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795005612 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795005613 Predicted membrane protein [Function unknown]; Region: COG2860 682795005614 UPF0126 domain; Region: UPF0126; pfam03458 682795005615 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 682795005616 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 682795005617 beta-galactosidase; Region: BGL; TIGR03356 682795005618 Uncharacterized conserved protein [Function unknown]; Region: COG5495 682795005619 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 682795005620 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795005621 Serine hydrolase; Region: Ser_hydrolase; pfam06821 682795005622 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 682795005623 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795005624 Predicted membrane protein [Function unknown]; Region: COG2311 682795005625 Protein of unknown function (DUF418); Region: DUF418; cl12135 682795005626 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 682795005627 active site 682795005628 catalytic triad [active] 682795005629 oxyanion hole [active] 682795005630 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795005631 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795005632 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 682795005633 putative ligand binding site [chemical binding]; other site 682795005634 putative catalytic site [active] 682795005635 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795005636 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 682795005637 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 682795005638 putative sugar binding sites [chemical binding]; other site 682795005639 Q-X-W motif; other site 682795005640 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 682795005641 putative metal binding site [ion binding]; other site 682795005642 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 682795005643 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 682795005644 substrate binding site [chemical binding]; other site 682795005645 catalytic residues [active] 682795005646 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795005647 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795005648 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795005649 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795005650 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795005652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795005653 DNA binding site [nucleotide binding] 682795005654 domain linker motif; other site 682795005655 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795005656 dimerization interface [polypeptide binding]; other site 682795005657 ligand binding site [chemical binding]; other site 682795005658 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 682795005659 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 682795005660 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 682795005661 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 682795005662 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795005663 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795005664 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795005665 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 682795005666 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005667 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 682795005668 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795005669 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 682795005670 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 682795005671 Protein of unknown function, DUF608; Region: DUF608; pfam04685 682795005672 Trehalose utilisation; Region: ThuA; pfam06283 682795005673 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 682795005674 A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570 682795005675 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 682795005676 active site 682795005677 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 682795005678 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795005679 putative catalytic residue [active] 682795005680 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795005681 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 682795005682 catalytic residues [active] 682795005683 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 682795005684 MarR family; Region: MarR_2; pfam12802 682795005685 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 682795005686 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795005687 nucleotide binding site [chemical binding]; other site 682795005688 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 682795005689 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 682795005690 dimer interface [polypeptide binding]; other site 682795005691 active site 682795005692 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 682795005693 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 682795005694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795005695 putative substrate translocation pore; other site 682795005696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795005697 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 682795005698 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795005699 nucleotide binding site [chemical binding]; other site 682795005700 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 682795005701 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 682795005702 Amino acid permease; Region: AA_permease_2; pfam13520 682795005703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005704 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 682795005705 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005706 active site 682795005707 GntP family permease; Region: GntP_permease; pfam02447 682795005708 fructuronate transporter; Provisional; Region: PRK10034; cl15264 682795005709 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 682795005710 homotrimer interaction site [polypeptide binding]; other site 682795005711 putative active site [active] 682795005712 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 682795005713 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 682795005714 active site 682795005715 putative substrate binding pocket [chemical binding]; other site 682795005716 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005717 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 682795005718 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 682795005719 dimer interface [polypeptide binding]; other site 682795005720 active site 682795005721 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 682795005722 substrate binding site [chemical binding]; other site 682795005723 catalytic residue [active] 682795005724 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 682795005725 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 682795005726 substrate binding pocket [chemical binding]; other site 682795005727 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795005728 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795005729 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795005730 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795005731 DNA binding site [nucleotide binding] 682795005732 domain linker motif; other site 682795005733 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795005734 dimerization interface [polypeptide binding]; other site 682795005735 ligand binding site [chemical binding]; other site 682795005736 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005737 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795005738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 682795005739 MOSC domain; Region: MOSC; pfam03473 682795005740 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 682795005741 Sulfatase; Region: Sulfatase; pfam00884 682795005742 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 682795005743 CHRD domain; Region: CHRD; pfam07452 682795005744 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005745 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795005746 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 682795005747 active site residue [active] 682795005748 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 682795005749 Protein of unknown function (DUF229); Region: DUF229; pfam02995 682795005750 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 682795005751 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 682795005752 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 682795005753 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 682795005754 BioY family; Region: BioY; pfam02632 682795005755 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 682795005756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795005757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795005758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 682795005759 dimerization interface [polypeptide binding]; other site 682795005760 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 682795005762 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 682795005763 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 682795005764 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 682795005765 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 682795005766 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 682795005767 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 682795005768 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 682795005769 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 682795005770 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 682795005771 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 682795005772 Walker A/P-loop; other site 682795005773 ATP binding site [chemical binding]; other site 682795005774 Q-loop/lid; other site 682795005775 ABC transporter signature motif; other site 682795005776 Walker B; other site 682795005777 D-loop; other site 682795005778 H-loop/switch region; other site 682795005779 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 682795005780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795005781 dimer interface [polypeptide binding]; other site 682795005782 conserved gate region; other site 682795005783 putative PBP binding loops; other site 682795005784 ABC-ATPase subunit interface; other site 682795005785 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 682795005786 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 682795005787 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 682795005788 catalytic residues [active] 682795005789 dimer interface [polypeptide binding]; other site 682795005790 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005791 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 682795005792 active site 682795005793 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 682795005794 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 682795005795 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 682795005796 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 682795005797 urea carboxylase; Region: urea_carbox; TIGR02712 682795005798 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 682795005799 ATP-grasp domain; Region: ATP-grasp_4; cl17255 682795005800 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 682795005801 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 682795005802 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 682795005803 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 682795005804 carboxyltransferase (CT) interaction site; other site 682795005805 biotinylation site [posttranslational modification]; other site 682795005806 allophanate hydrolase; Provisional; Region: PRK08186 682795005807 Amidase; Region: Amidase; cl11426 682795005808 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 682795005809 active site 682795005810 catalytic site [active] 682795005811 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 682795005812 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 682795005813 Ca binding site [ion binding]; other site 682795005814 substrate binding site [chemical binding]; other site 682795005815 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005816 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 682795005817 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795005818 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795005819 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795005820 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 682795005821 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795005822 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795005823 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795005824 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 682795005825 classical (c) SDRs; Region: SDR_c; cd05233 682795005826 NAD(P) binding site [chemical binding]; other site 682795005827 active site 682795005828 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 682795005829 active site 682795005830 catalytic triad [active] 682795005831 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 682795005832 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795005833 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 682795005834 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 682795005835 active site 682795005836 catalytic triad [active] 682795005837 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 682795005838 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 682795005839 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795005840 alpha-galactosidase; Region: PLN02808; cl17638 682795005841 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795005842 Ca binding site [ion binding]; other site 682795005843 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795005844 Ca binding site [ion binding]; other site 682795005845 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795005846 Amidase; Region: Amidase; pfam01425 682795005847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795005848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795005849 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 682795005850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795005851 putative NAD(P) binding site [chemical binding]; other site 682795005852 Cupin; Region: Cupin_6; pfam12852 682795005853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795005854 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795005855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795005856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795005857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795005858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795005859 NAD(P) binding site [chemical binding]; other site 682795005860 active site 682795005861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795005862 Coenzyme A binding pocket [chemical binding]; other site 682795005863 RibD C-terminal domain; Region: RibD_C; cl17279 682795005864 YCII-related domain; Region: YCII; cl00999 682795005865 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795005866 Cupin domain; Region: Cupin_2; pfam07883 682795005867 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005868 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795005869 GAF domain; Region: GAF_3; pfam13492 682795005870 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 682795005871 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 682795005872 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_1; cd11747 682795005873 homodimer interface [polypeptide binding]; other site 682795005874 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 682795005875 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005876 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795005877 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 682795005878 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 682795005879 Pectic acid lyase; Region: Pec_lyase; pfam09492 682795005880 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 682795005881 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 682795005882 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005883 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795005884 Amidohydrolase; Region: Amidohydro_4; pfam13147 682795005885 active site 682795005886 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005887 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795005888 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 682795005889 homotrimer interaction site [polypeptide binding]; other site 682795005890 putative active site [active] 682795005891 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 682795005892 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 682795005893 tetramer interface [polypeptide binding]; other site 682795005894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795005895 catalytic residue [active] 682795005896 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 682795005897 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 682795005898 E-class dimer interface [polypeptide binding]; other site 682795005899 P-class dimer interface [polypeptide binding]; other site 682795005900 active site 682795005901 Cu2+ binding site [ion binding]; other site 682795005902 Zn2+ binding site [ion binding]; other site 682795005903 Repair protein; Region: Repair_PSII; pfam04536 682795005904 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 682795005905 Viral RNA dependent RNA polymerase; Region: RdRP_3; pfam00998 682795005906 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 682795005907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795005908 non-specific DNA binding site [nucleotide binding]; other site 682795005909 salt bridge; other site 682795005910 sequence-specific DNA binding site [nucleotide binding]; other site 682795005911 oxidoreductase; Provisional; Region: PRK06196 682795005912 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 682795005913 putative NAD(P) binding site [chemical binding]; other site 682795005914 active site 682795005915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795005916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795005917 SnoaL-like domain; Region: SnoaL_4; cl17707 682795005918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 682795005919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795005920 non-specific DNA binding site [nucleotide binding]; other site 682795005921 salt bridge; other site 682795005922 sequence-specific DNA binding site [nucleotide binding]; other site 682795005923 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 682795005924 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 682795005925 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 682795005926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795005927 active site 682795005928 motif I; other site 682795005929 motif II; other site 682795005930 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 682795005931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 682795005932 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 682795005933 biotin synthase; Region: bioB; TIGR00433 682795005934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795005935 FeS/SAM binding site; other site 682795005936 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 682795005937 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005938 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795005939 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 682795005940 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 682795005941 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 682795005942 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 682795005943 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 682795005944 putative metal binding site [ion binding]; other site 682795005945 putative homodimer interface [polypeptide binding]; other site 682795005946 putative homotetramer interface [polypeptide binding]; other site 682795005947 putative homodimer-homodimer interface [polypeptide binding]; other site 682795005948 putative allosteric switch controlling residues; other site 682795005949 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795005950 magnesium transport protein MgtC; Provisional; Region: PRK15385 682795005951 MgtC family; Region: MgtC; pfam02308 682795005952 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 682795005953 adenosine deaminase; Provisional; Region: PRK09358 682795005954 active site 682795005955 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 682795005956 putative FMN binding site [chemical binding]; other site 682795005957 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795005958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 682795005959 Predicted membrane protein [Function unknown]; Region: COG2510 682795005960 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 682795005961 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 682795005962 aromatic arch; other site 682795005963 DCoH dimer interaction site [polypeptide binding]; other site 682795005964 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 682795005965 DCoH tetramer interaction site [polypeptide binding]; other site 682795005966 substrate binding site [chemical binding]; other site 682795005967 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 682795005968 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 682795005969 Substrate binding site; other site 682795005970 Mg++ binding site; other site 682795005971 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 682795005972 active site 682795005973 substrate binding site [chemical binding]; other site 682795005974 CoA binding site [chemical binding]; other site 682795005975 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 682795005976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795005977 ATP binding site [chemical binding]; other site 682795005978 putative Mg++ binding site [ion binding]; other site 682795005979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 682795005980 nucleotide binding region [chemical binding]; other site 682795005981 ATP-binding site [chemical binding]; other site 682795005982 HRDC domain; Region: HRDC; pfam00570 682795005983 HRDC domain; Region: HRDC; pfam00570 682795005984 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 682795005985 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 682795005986 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 682795005987 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 682795005988 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 682795005989 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 682795005990 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 682795005991 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 682795005992 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 682795005993 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 682795005994 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 682795005995 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 682795005996 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 682795005997 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 682795005998 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 682795005999 Multicopper oxidase; Region: Cu-oxidase; pfam00394 682795006000 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 682795006001 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 682795006002 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 682795006003 conserved cys residue [active] 682795006004 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 682795006005 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 682795006006 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 682795006007 dimerization interface [polypeptide binding]; other site 682795006008 active site 682795006009 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 682795006010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795006011 motif II; other site 682795006012 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 682795006013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795006014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795006015 homodimer interface [polypeptide binding]; other site 682795006016 catalytic residue [active] 682795006017 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 682795006018 Preprotein translocase SecG subunit; Region: SecG; pfam03840 682795006019 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795006020 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 682795006021 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 682795006022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795006023 motif II; other site 682795006024 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 682795006025 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795006026 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 682795006027 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795006028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795006029 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795006030 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 682795006031 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 682795006032 hinge; other site 682795006033 active site 682795006034 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 682795006035 active site 682795006036 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 682795006037 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795006038 Protein of unknown function DUF45; Region: DUF45; cl00636 682795006039 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795006040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006041 TPR motif; other site 682795006042 binding surface 682795006043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006044 TPR motif; other site 682795006045 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 682795006046 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 682795006047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795006048 ABC transporter signature motif; other site 682795006049 Walker B; other site 682795006050 D-loop; other site 682795006051 H-loop/switch region; other site 682795006052 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 682795006053 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 682795006054 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 682795006055 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 682795006056 active site 682795006057 HIGH motif; other site 682795006058 nucleotide binding site [chemical binding]; other site 682795006059 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 682795006060 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 682795006061 active site 682795006062 KMSKS motif; other site 682795006063 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 682795006064 tRNA binding surface [nucleotide binding]; other site 682795006065 anticodon binding site; other site 682795006066 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 682795006067 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795006068 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 682795006069 putative active site [active] 682795006070 putative metal binding residues [ion binding]; other site 682795006071 signature motif; other site 682795006072 putative triphosphate binding site [ion binding]; other site 682795006073 dimer interface [polypeptide binding]; other site 682795006074 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 682795006075 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 682795006076 Sm and related proteins; Region: Sm_like; cl00259 682795006077 heptamer interface [polypeptide binding]; other site 682795006078 Sm1 motif; other site 682795006079 hexamer interface [polypeptide binding]; other site 682795006080 RNA binding site [nucleotide binding]; other site 682795006081 Sm2 motif; other site 682795006082 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 682795006083 DNA polymerase III subunit delta'; Validated; Region: PRK05564 682795006084 DNA polymerase III subunit delta'; Validated; Region: PRK08485 682795006085 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 682795006086 Cytochrome P450; Region: p450; cl12078 682795006087 thymidylate kinase; Validated; Region: tmk; PRK00698 682795006088 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 682795006089 TMP-binding site; other site 682795006090 ATP-binding site [chemical binding]; other site 682795006091 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 682795006092 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 682795006093 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 682795006094 trimer interface [polypeptide binding]; other site 682795006095 active site 682795006096 UDP-GlcNAc binding site [chemical binding]; other site 682795006097 lipid binding site [chemical binding]; lipid-binding site 682795006098 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 682795006099 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 682795006100 active site 682795006101 NTP binding site [chemical binding]; other site 682795006102 metal binding triad [ion binding]; metal-binding site 682795006103 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 682795006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795006105 active site 682795006106 phosphorylation site [posttranslational modification] 682795006107 intermolecular recognition site; other site 682795006108 dimerization interface [polypeptide binding]; other site 682795006109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795006110 Walker A motif; other site 682795006111 ATP binding site [chemical binding]; other site 682795006112 Walker B motif; other site 682795006113 arginine finger; other site 682795006114 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 682795006115 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 682795006116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795006117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 682795006118 putative active site [active] 682795006119 heme pocket [chemical binding]; other site 682795006120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795006121 dimer interface [polypeptide binding]; other site 682795006122 phosphorylation site [posttranslational modification] 682795006123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795006124 ATP binding site [chemical binding]; other site 682795006125 Mg2+ binding site [ion binding]; other site 682795006126 G-X-G motif; other site 682795006127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795006128 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 682795006129 catalytic site [active] 682795006130 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795006131 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 682795006132 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like_fungal; cd05652 682795006133 metal binding site [ion binding]; metal-binding site 682795006134 putative dimer interface [polypeptide binding]; other site 682795006135 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 682795006136 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 682795006137 active site 682795006138 PHP Thumb interface [polypeptide binding]; other site 682795006139 metal binding site [ion binding]; metal-binding site 682795006140 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 682795006141 generic binding surface I; other site 682795006142 generic binding surface II; other site 682795006143 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795006144 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 682795006145 CAAX protease self-immunity; Region: Abi; pfam02517 682795006146 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 682795006147 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 682795006148 Transcriptional regulators [Transcription]; Region: GntR; COG1802 682795006149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795006150 DNA-binding site [nucleotide binding]; DNA binding site 682795006151 FCD domain; Region: FCD; pfam07729 682795006152 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006153 alpha-galactosidase; Region: PLN02229 682795006154 alpha-galactosidase; Region: PLN02808; cl17638 682795006155 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795006156 Ca binding site [ion binding]; other site 682795006157 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795006158 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 682795006159 Amidinotransferase; Region: Amidinotransf; cl12043 682795006160 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 682795006161 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 682795006162 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 682795006163 dimer interface [polypeptide binding]; other site 682795006164 substrate binding site [chemical binding]; other site 682795006165 ATP binding site [chemical binding]; other site 682795006166 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 682795006167 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 682795006168 thiS-thiF/thiG interaction site; other site 682795006169 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 682795006170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795006171 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 682795006172 Interdomain contacts; other site 682795006173 Cytokine receptor motif; other site 682795006174 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 682795006175 putative metal binding site [ion binding]; other site 682795006176 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 682795006177 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 682795006178 putative sugar binding sites [chemical binding]; other site 682795006179 Q-X-W motif; other site 682795006180 Aspartyl protease; Region: Asp_protease_2; pfam13650 682795006181 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 682795006182 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 682795006183 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795006184 XrtJ-associated TM-motif-TM protein; Region: targ_of_XrtJ; TIGR04200 682795006185 exosortase J; Region: exosort_xrtJ; TIGR04199 682795006186 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 682795006187 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 682795006188 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 682795006189 putative sugar binding sites [chemical binding]; other site 682795006190 Q-X-W motif; other site 682795006191 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 682795006192 active site 682795006193 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 682795006194 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 682795006195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795006196 putative active site [active] 682795006197 heme pocket [chemical binding]; other site 682795006198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795006199 putative active site [active] 682795006200 heme pocket [chemical binding]; other site 682795006201 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 682795006202 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 682795006203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795006204 PAS fold; Region: PAS_3; pfam08447 682795006205 putative active site [active] 682795006206 heme pocket [chemical binding]; other site 682795006207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795006208 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 682795006209 putative active site [active] 682795006210 heme pocket [chemical binding]; other site 682795006211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795006212 dimer interface [polypeptide binding]; other site 682795006213 phosphorylation site [posttranslational modification] 682795006214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795006215 ATP binding site [chemical binding]; other site 682795006216 G-X-G motif; other site 682795006217 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 682795006218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795006219 active site 682795006220 phosphorylation site [posttranslational modification] 682795006221 intermolecular recognition site; other site 682795006222 dimerization interface [polypeptide binding]; other site 682795006223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795006224 DNA binding residues [nucleotide binding] 682795006225 dimerization interface [polypeptide binding]; other site 682795006226 Response regulator receiver domain; Region: Response_reg; pfam00072 682795006227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795006228 active site 682795006229 phosphorylation site [posttranslational modification] 682795006230 intermolecular recognition site; other site 682795006231 dimerization interface [polypeptide binding]; other site 682795006232 Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857 682795006233 emp24/gp25L/p24 family/GOLD; Region: EMP24_GP25L; pfam01105 682795006234 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 682795006235 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 682795006236 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 682795006237 putative active site [active] 682795006238 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 682795006239 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 682795006240 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 682795006241 protein binding site [polypeptide binding]; other site 682795006242 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 682795006243 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795006244 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795006245 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795006246 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 682795006247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795006248 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 682795006249 dimerization interface [polypeptide binding]; other site 682795006250 substrate binding pocket [chemical binding]; other site 682795006251 Cupin; Region: Cupin_1; smart00835 682795006252 Cupin; Region: Cupin_1; smart00835 682795006253 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 682795006254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006255 binding surface 682795006256 TPR motif; other site 682795006257 Tetratricopeptide repeat; Region: TPR_12; pfam13424 682795006258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006259 binding surface 682795006260 TPR motif; other site 682795006261 TPR repeat; Region: TPR_11; pfam13414 682795006262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006263 binding surface 682795006264 TPR motif; other site 682795006265 TPR repeat; Region: TPR_11; pfam13414 682795006266 Cna protein B-type domain; Region: Cna_B_2; pfam13715 682795006267 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 682795006268 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006270 TPR motif; other site 682795006271 binding surface 682795006272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006273 TPR motif; other site 682795006274 TPR repeat; Region: TPR_11; pfam13414 682795006275 binding surface 682795006276 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795006277 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 682795006278 PA14 domain; Region: PA14; cl08459 682795006279 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795006280 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795006281 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795006282 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 682795006283 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795006284 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795006285 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006286 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795006287 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 682795006288 putative active site [active] 682795006289 catalytic site [active] 682795006290 putative metal binding site [ion binding]; other site 682795006291 Amidohydrolase; Region: Amidohydro_2; pfam04909 682795006292 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 682795006293 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 682795006294 Fasciclin domain; Region: Fasciclin; pfam02469 682795006295 Ferritin-like domain; Region: Ferritin_2; pfam13668 682795006296 Ferritin-like domain; Region: Ferritin_2; pfam13668 682795006297 RNA polymerase sigma factor; Provisional; Region: PRK12519 682795006298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795006299 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795006300 DNA binding residues [nucleotide binding] 682795006301 Anti-sigma-K factor rskA; Region: RskA; pfam10099 682795006302 Bifunctional nuclease; Region: DNase-RNase; pfam02577 682795006303 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 682795006304 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 682795006305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795006306 FeS/SAM binding site; other site 682795006307 TRAM domain; Region: TRAM; cl01282 682795006308 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 682795006309 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 682795006310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795006311 S-adenosylmethionine binding site [chemical binding]; other site 682795006312 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 682795006313 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 682795006314 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 682795006315 active site 682795006316 metal binding site [ion binding]; metal-binding site 682795006317 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795006318 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006319 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795006320 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 682795006321 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795006322 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795006323 Amidohydrolase; Region: Amidohydro_2; pfam04909 682795006324 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 682795006325 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 682795006326 Cl- selectivity filter; other site 682795006327 Cl- binding residues [ion binding]; other site 682795006328 pore gating glutamate residue; other site 682795006329 dimer interface [polypeptide binding]; other site 682795006330 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 682795006331 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 682795006332 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 682795006333 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 682795006334 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795006335 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795006336 Domain of unknown function (DUF756); Region: DUF756; pfam05506 682795006337 Domain of unknown function (DUF756); Region: DUF756; pfam05506 682795006338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795006339 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795006340 active site 682795006341 catalytic tetrad [active] 682795006342 Predicted acyl esterases [General function prediction only]; Region: COG2936 682795006343 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 682795006344 MarC family integral membrane protein; Region: MarC; pfam01914 682795006345 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795006346 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006347 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795006348 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795006349 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 682795006350 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795006351 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 682795006352 Penicillinase repressor; Region: Pencillinase_R; pfam03965 682795006353 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795006354 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795006355 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795006356 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795006357 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795006358 Uncharacterized conserved protein [Function unknown]; Region: COG3538 682795006359 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 682795006360 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 682795006361 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795006362 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795006363 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006364 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795006365 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 682795006366 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 682795006367 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 682795006368 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 682795006369 A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570 682795006370 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 682795006371 active site 682795006372 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 682795006373 Part of AAA domain; Region: AAA_19; pfam13245 682795006374 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 682795006375 AAA domain; Region: AAA_12; pfam13087 682795006376 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 682795006377 elongation factor P; Validated; Region: PRK00529 682795006378 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 682795006379 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 682795006380 RNA binding site [nucleotide binding]; other site 682795006381 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 682795006382 RNA binding site [nucleotide binding]; other site 682795006383 glycerol kinase; Provisional; Region: glpK; PRK00047 682795006384 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 682795006385 N- and C-terminal domain interface [polypeptide binding]; other site 682795006386 active site 682795006387 MgATP binding site [chemical binding]; other site 682795006388 catalytic site [active] 682795006389 metal binding site [ion binding]; metal-binding site 682795006390 glycerol binding site [chemical binding]; other site 682795006391 homotetramer interface [polypeptide binding]; other site 682795006392 homodimer interface [polypeptide binding]; other site 682795006393 FBP binding site [chemical binding]; other site 682795006394 protein IIAGlc interface [polypeptide binding]; other site 682795006395 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 682795006396 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 682795006397 amphipathic channel; other site 682795006398 Asn-Pro-Ala signature motifs; other site 682795006399 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 682795006400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795006401 active site 682795006402 motif I; other site 682795006403 motif II; other site 682795006404 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 682795006405 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 682795006406 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 682795006407 active site 682795006408 homotetramer interface [polypeptide binding]; other site 682795006409 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 682795006410 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 682795006411 trimer interface [polypeptide binding]; other site 682795006412 active site 682795006413 substrate binding site [chemical binding]; other site 682795006414 CoA binding site [chemical binding]; other site 682795006415 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795006416 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 682795006417 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 682795006418 phosphate binding site [ion binding]; other site 682795006419 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006420 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 682795006421 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795006422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 682795006423 TPR motif; other site 682795006424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795006425 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795006426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795006427 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 682795006428 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 682795006429 catalytic loop [active] 682795006430 iron binding site [ion binding]; other site 682795006431 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 682795006432 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 682795006433 [4Fe-4S] binding site [ion binding]; other site 682795006434 molybdopterin cofactor binding site; other site 682795006435 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 682795006436 molybdopterin cofactor binding site; other site 682795006437 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 682795006438 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 682795006439 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 682795006440 Cupin; Region: Cupin_1; smart00835 682795006441 Cupin; Region: Cupin_1; smart00835 682795006442 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 682795006443 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 682795006444 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006445 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795006446 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 682795006447 active site 682795006448 catalytic triad [active] 682795006449 oxyanion hole [active] 682795006450 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 682795006451 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 682795006452 Condensation domain; Region: Condensation; pfam00668 682795006453 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 682795006454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795006455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795006456 DNA binding residues [nucleotide binding] 682795006457 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 682795006458 Putative zinc-finger; Region: zf-HC2; pfam13490 682795006459 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 682795006460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795006461 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 682795006462 putative ADP-binding pocket [chemical binding]; other site 682795006463 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795006464 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 682795006465 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795006466 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 682795006467 Acyltransferase family; Region: Acyl_transf_3; pfam01757 682795006468 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795006469 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795006470 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 682795006471 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 682795006472 SLBB domain; Region: SLBB; pfam10531 682795006473 Chain length determinant protein; Region: Wzz; cl15801 682795006474 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 682795006475 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795006476 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 682795006477 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795006478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795006479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795006480 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795006481 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795006482 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795006483 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 682795006484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795006485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795006486 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795006487 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 682795006488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 682795006489 active site 682795006490 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795006491 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 682795006492 Acyltransferase family; Region: Acyl_transf_3; pfam01757 682795006493 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 682795006494 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 682795006495 Ligand binding site; other site 682795006496 Putative Catalytic site; other site 682795006497 DXD motif; other site 682795006498 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 682795006499 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 682795006500 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 682795006501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006502 binding surface 682795006503 TPR motif; other site 682795006504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006505 binding surface 682795006506 TPR motif; other site 682795006507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795006508 binding surface 682795006509 TPR motif; other site 682795006510 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006511 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795006512 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 682795006513 active site 682795006514 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 682795006515 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 682795006516 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 682795006517 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 682795006518 coenzyme PQQ biosynthesis enzyme PqqE; Region: PQQ_syn_pqqE; TIGR02109 682795006519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795006520 FeS/SAM binding site; other site 682795006521 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 682795006522 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 682795006523 Protein of unknown function (DUF507); Region: DUF507; cl01112 682795006524 Protein of unknown function (DUF507); Region: DUF507; cl01112 682795006525 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 682795006526 DHH family; Region: DHH; pfam01368 682795006527 DHHA1 domain; Region: DHHA1; pfam02272 682795006528 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795006529 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795006530 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 682795006531 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 682795006532 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 682795006533 B12 binding domain; Region: B12-binding; pfam02310 682795006534 B12 binding site [chemical binding]; other site 682795006535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795006536 FeS/SAM binding site; other site 682795006537 EamA-like transporter family; Region: EamA; pfam00892 682795006538 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 682795006539 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 682795006540 active site lid residues [active] 682795006541 substrate binding pocket [chemical binding]; other site 682795006542 catalytic residues [active] 682795006543 substrate-Mg2+ binding site; other site 682795006544 aspartate-rich region 1; other site 682795006545 aspartate-rich region 2; other site 682795006546 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 682795006547 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 682795006548 NAD(P) binding site [chemical binding]; other site 682795006549 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 682795006550 Permease; Region: Permease; pfam02405 682795006551 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 682795006552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795006553 Walker A/P-loop; other site 682795006554 ATP binding site [chemical binding]; other site 682795006555 Q-loop/lid; other site 682795006556 ABC transporter signature motif; other site 682795006557 Walker B; other site 682795006558 D-loop; other site 682795006559 H-loop/switch region; other site 682795006560 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 682795006561 Phosphopantetheine attachment site; Region: PP-binding; cl09936 682795006562 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 682795006563 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 682795006564 dimer interface [polypeptide binding]; other site 682795006565 active site 682795006566 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795006567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795006568 NAD(P) binding site [chemical binding]; other site 682795006569 active site 682795006570 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 682795006571 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 682795006572 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795006573 catalytic residue [active] 682795006574 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 682795006575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795006576 dimer interface [polypeptide binding]; other site 682795006577 conserved gate region; other site 682795006578 putative PBP binding loops; other site 682795006579 ABC-ATPase subunit interface; other site 682795006580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795006581 dimer interface [polypeptide binding]; other site 682795006582 conserved gate region; other site 682795006583 putative PBP binding loops; other site 682795006584 ABC-ATPase subunit interface; other site 682795006585 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 682795006586 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 682795006587 Walker A/P-loop; other site 682795006588 ATP binding site [chemical binding]; other site 682795006589 Q-loop/lid; other site 682795006590 ABC transporter signature motif; other site 682795006591 Walker B; other site 682795006592 D-loop; other site 682795006593 H-loop/switch region; other site 682795006594 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 682795006595 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 682795006596 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 682795006597 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 682795006598 NADP binding site [chemical binding]; other site 682795006599 active site 682795006600 putative substrate binding site [chemical binding]; other site 682795006601 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 682795006602 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 682795006603 substrate binding site; other site 682795006604 tetramer interface; other site 682795006605 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 682795006606 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 682795006607 NAD binding site [chemical binding]; other site 682795006608 substrate binding site [chemical binding]; other site 682795006609 homodimer interface [polypeptide binding]; other site 682795006610 active site 682795006611 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 682795006612 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 682795006613 active site 682795006614 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 682795006615 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 682795006616 SLBB domain; Region: SLBB; pfam10531 682795006617 SLBB domain; Region: SLBB; pfam10531 682795006618 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 682795006619 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 682795006620 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795006621 Cupin domain; Region: Cupin_2; pfam07883 682795006622 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 682795006623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795006624 putative substrate translocation pore; other site 682795006625 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 682795006626 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 682795006627 active site 682795006628 FOG: WD40 repeat [General function prediction only]; Region: COG2319 682795006629 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 682795006630 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795006631 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006632 SnoaL-like domain; Region: SnoaL_2; pfam12680 682795006633 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795006634 RibD C-terminal domain; Region: RibD_C; cl17279 682795006635 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 682795006636 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795006637 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 682795006638 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795006639 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795006640 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 682795006641 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795006642 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 682795006643 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 682795006644 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795006645 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 682795006646 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 682795006647 active site 682795006648 MEKHLA domain; Region: MEKHLA; pfam08670 682795006649 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 682795006650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795006651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795006652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795006653 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 682795006654 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 682795006655 FAD binding domain; Region: FAD_binding_4; pfam01565 682795006656 Berberine and berberine like; Region: BBE; pfam08031 682795006657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795006658 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795006659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795006660 Putative cyclase; Region: Cyclase; pfam04199 682795006661 Putative cyclase; Region: Cyclase; cl00814 682795006662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 682795006663 Zn2+ binding site [ion binding]; other site 682795006664 Mg2+ binding site [ion binding]; other site 682795006665 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795006666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795006667 putative substrate translocation pore; other site 682795006668 Transcriptional regulators [Transcription]; Region: MarR; COG1846 682795006669 MarR family; Region: MarR_2; pfam12802 682795006670 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 682795006671 putative amphipathic alpha helix; other site 682795006672 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 682795006673 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 682795006674 FAD binding domain; Region: FAD_binding_4; pfam01565 682795006675 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 682795006676 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795006677 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795006678 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795006679 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 682795006680 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 682795006681 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 682795006682 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 682795006683 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 682795006684 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 682795006685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795006686 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795006687 NAD(P) binding site [chemical binding]; other site 682795006688 active site 682795006689 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 682795006690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795006691 dimer interface [polypeptide binding]; other site 682795006692 conserved gate region; other site 682795006693 putative PBP binding loops; other site 682795006694 ABC-ATPase subunit interface; other site 682795006695 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 682795006696 active site 682795006697 metal binding site [ion binding]; metal-binding site 682795006698 homotetramer interface [polypeptide binding]; other site 682795006699 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 682795006700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795006701 dimer interface [polypeptide binding]; other site 682795006702 conserved gate region; other site 682795006703 putative PBP binding loops; other site 682795006704 ABC-ATPase subunit interface; other site 682795006705 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 682795006706 Domain of unknown function DUF21; Region: DUF21; pfam01595 682795006707 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 682795006708 Transporter associated domain; Region: CorC_HlyC; smart01091 682795006709 Protein of unknown function (DUF433); Region: DUF433; pfam04255 682795006710 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 682795006711 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795006712 catalytic residues [active] 682795006713 homoserine kinase; Provisional; Region: PRK01212 682795006714 threonine synthase; Validated; Region: PRK06260 682795006715 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 682795006716 homodimer interface [polypeptide binding]; other site 682795006717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795006718 catalytic residue [active] 682795006719 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 682795006720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 682795006721 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 682795006722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 682795006723 dimer interface [polypeptide binding]; other site 682795006724 conserved gate region; other site 682795006725 putative PBP binding loops; other site 682795006726 ABC-ATPase subunit interface; other site 682795006727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795006728 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 682795006729 Walker A/P-loop; other site 682795006730 ATP binding site [chemical binding]; other site 682795006731 Q-loop/lid; other site 682795006732 ABC transporter signature motif; other site 682795006733 Walker B; other site 682795006734 D-loop; other site 682795006735 H-loop/switch region; other site 682795006736 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 682795006737 FAD binding domain; Region: FAD_binding_4; pfam01565 682795006738 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 682795006739 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 682795006740 pyrroline-5-carboxylate reductase; Region: PLN02688 682795006741 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 682795006742 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 682795006743 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 682795006744 hypothetical protein; Provisional; Region: PRK06062 682795006745 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 682795006746 inhibitor-cofactor binding pocket; inhibition site 682795006747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795006748 catalytic residue [active] 682795006749 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 682795006750 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 682795006751 Na binding site [ion binding]; other site 682795006752 putative substrate binding site [chemical binding]; other site 682795006753 phenylhydantoinase; Validated; Region: PRK08323 682795006754 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 682795006755 tetramer interface [polypeptide binding]; other site 682795006756 active site 682795006757 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 682795006758 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 682795006759 homodimer interface [polypeptide binding]; other site 682795006760 active site 682795006761 FMN binding site [chemical binding]; other site 682795006762 substrate binding site [chemical binding]; other site 682795006763 4Fe-4S binding domain; Region: Fer4; cl02805 682795006764 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 682795006765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 682795006766 allantoate amidohydrolase; Reviewed; Region: PRK09290 682795006767 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 682795006768 active site 682795006769 metal binding site [ion binding]; metal-binding site 682795006770 dimer interface [polypeptide binding]; other site 682795006771 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795006772 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 682795006773 PA14 domain; Region: PA14; cl08459 682795006774 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795006775 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 682795006776 active site 682795006777 catalytic triad [active] 682795006778 oxyanion hole [active] 682795006779 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 682795006780 alpha-galactosidase; Region: PLN02692 682795006781 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006782 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795006783 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795006784 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 682795006785 putative transporter; Provisional; Region: PRK10484 682795006786 Na binding site [ion binding]; other site 682795006787 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 682795006788 Melibiase; Region: Melibiase; pfam02065 682795006789 alpha-galactosidase; Region: PLN02229 682795006790 alpha-galactosidase; Region: PLN02808; cl17638 682795006791 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795006792 Ca binding site [ion binding]; other site 682795006793 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795006794 Ca binding site [ion binding]; other site 682795006795 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795006796 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795006797 DNA binding site [nucleotide binding] 682795006798 domain linker motif; other site 682795006799 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795006800 dimerization interface [polypeptide binding]; other site 682795006801 ligand binding site [chemical binding]; other site 682795006802 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 682795006803 classical (c) SDRs; Region: SDR_c; cd05233 682795006804 NAD(P) binding site [chemical binding]; other site 682795006805 active site 682795006806 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 682795006807 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 682795006808 metal binding site [ion binding]; metal-binding site 682795006809 substrate binding pocket [chemical binding]; other site 682795006810 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 682795006811 Transcriptional regulators [Transcription]; Region: GntR; COG1802 682795006812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795006813 DNA-binding site [nucleotide binding]; DNA binding site 682795006814 FCD domain; Region: FCD; pfam07729 682795006815 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 682795006816 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795006817 nucleotide binding site [chemical binding]; other site 682795006818 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 682795006819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795006820 putative substrate translocation pore; other site 682795006821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795006822 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 682795006823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795006824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795006825 DNA binding site [nucleotide binding] 682795006826 domain linker motif; other site 682795006827 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795006828 dimerization interface [polypeptide binding]; other site 682795006829 ligand binding site [chemical binding]; other site 682795006830 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 682795006831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795006832 active site 682795006833 phosphorylation site [posttranslational modification] 682795006834 intermolecular recognition site; other site 682795006835 dimerization interface [polypeptide binding]; other site 682795006836 LytTr DNA-binding domain; Region: LytTR; smart00850 682795006837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 682795006838 Histidine kinase; Region: His_kinase; pfam06580 682795006839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795006840 ATP binding site [chemical binding]; other site 682795006841 Mg2+ binding site [ion binding]; other site 682795006842 G-X-G motif; other site 682795006843 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 682795006844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795006845 putative substrate translocation pore; other site 682795006846 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 682795006847 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 682795006848 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 682795006849 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 682795006850 RNA binding site [nucleotide binding]; other site 682795006851 recombination factor protein RarA; Reviewed; Region: PRK13342 682795006852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795006853 Walker A motif; other site 682795006854 ATP binding site [chemical binding]; other site 682795006855 Walker B motif; other site 682795006856 arginine finger; other site 682795006857 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 682795006858 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 682795006859 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 682795006860 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 682795006861 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 682795006862 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 682795006863 putative active site [active] 682795006864 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 682795006865 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 682795006866 peptide chain release factor 2; Validated; Region: prfB; PRK00578 682795006867 This domain is found in peptide chain release factors; Region: PCRF; smart00937 682795006868 RF-1 domain; Region: RF-1; pfam00472 682795006869 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 682795006870 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 682795006871 putative active site [active] 682795006872 catalytic triad [active] 682795006873 putative dimer interface [polypeptide binding]; other site 682795006874 Methyltransferase domain; Region: Methyltransf_25; pfam13649 682795006875 S-adenosylmethionine binding site [chemical binding]; other site 682795006876 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 682795006877 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 682795006878 active site 682795006879 octamer interface [polypeptide binding]; other site 682795006880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795006881 Coenzyme A binding pocket [chemical binding]; other site 682795006882 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 682795006883 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 682795006884 homodimer interface [polypeptide binding]; other site 682795006885 metal binding site [ion binding]; metal-binding site 682795006886 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 682795006887 homodimer interface [polypeptide binding]; other site 682795006888 active site 682795006889 putative chemical substrate binding site [chemical binding]; other site 682795006890 metal binding site [ion binding]; metal-binding site 682795006891 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 682795006892 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 682795006893 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 682795006894 GIY-YIG motif/motif A; other site 682795006895 active site 682795006896 catalytic site [active] 682795006897 putative DNA binding site [nucleotide binding]; other site 682795006898 metal binding site [ion binding]; metal-binding site 682795006899 UvrB/uvrC motif; Region: UVR; pfam02151 682795006900 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 682795006901 Y-family of DNA polymerases; Region: PolY; cl12025 682795006902 PIN domain; Region: PIN; pfam01850 682795006903 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 682795006904 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 682795006905 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 682795006906 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 682795006907 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 682795006908 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 682795006909 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 682795006910 active site 682795006911 putative DNA-binding cleft [nucleotide binding]; other site 682795006912 dimer interface [polypeptide binding]; other site 682795006913 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 682795006914 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 682795006915 active site 682795006916 metal binding site [ion binding]; metal-binding site 682795006917 Sporulation and spore germination; Region: Germane; pfam10646 682795006918 glutamate racemase; Provisional; Region: PRK00865 682795006919 EVE domain; Region: EVE; pfam01878 682795006920 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 682795006921 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 682795006922 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 682795006923 active site 682795006924 catalytic site [active] 682795006925 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 682795006926 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 682795006927 NAD binding site [chemical binding]; other site 682795006928 homotetramer interface [polypeptide binding]; other site 682795006929 homodimer interface [polypeptide binding]; other site 682795006930 substrate binding site [chemical binding]; other site 682795006931 active site 682795006932 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 682795006933 Helix-turn-helix domain; Region: HTH_38; pfam13936 682795006934 Integrase core domain; Region: rve; pfam00665 682795006935 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 682795006936 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 682795006937 Walker A/P-loop; other site 682795006938 ATP binding site [chemical binding]; other site 682795006939 Q-loop/lid; other site 682795006940 ABC transporter signature motif; other site 682795006941 Walker B; other site 682795006942 D-loop; other site 682795006943 H-loop/switch region; other site 682795006944 ABC transporter; Region: ABC_tran_2; pfam12848 682795006945 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 682795006946 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 682795006947 PLD-like domain; Region: PLDc_2; pfam13091 682795006948 putative active site [active] 682795006949 putative catalytic site [active] 682795006950 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 682795006951 PLD-like domain; Region: PLDc_2; pfam13091 682795006952 putative active site [active] 682795006953 putative catalytic site [active] 682795006954 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 682795006955 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 682795006956 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 682795006957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 682795006958 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 682795006959 dimer interface [polypeptide binding]; other site 682795006960 ADP-ribose binding site [chemical binding]; other site 682795006961 active site 682795006962 nudix motif; other site 682795006963 metal binding site [ion binding]; metal-binding site 682795006964 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 682795006965 DNA-binding site [nucleotide binding]; DNA binding site 682795006966 RNA-binding motif; other site 682795006967 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 682795006968 hypothetical protein; Provisional; Region: PRK08609 682795006969 active site 682795006970 primer binding site [nucleotide binding]; other site 682795006971 NTP binding site [chemical binding]; other site 682795006972 metal binding triad [ion binding]; metal-binding site 682795006973 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 682795006974 active site 682795006975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795006976 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 682795006977 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 682795006978 dimer interface [polypeptide binding]; other site 682795006979 Citrate synthase; Region: Citrate_synt; pfam00285 682795006980 active site 682795006981 citrylCoA binding site [chemical binding]; other site 682795006982 oxalacetate/citrate binding site [chemical binding]; other site 682795006983 coenzyme A binding site [chemical binding]; other site 682795006984 catalytic triad [active] 682795006985 DinB superfamily; Region: DinB_2; pfam12867 682795006986 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 682795006987 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 682795006988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795006989 catalytic residue [active] 682795006990 Amino acid permease; Region: AA_permease_2; pfam13520 682795006991 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 682795006992 catalytic residues [active] 682795006993 dimer interface [polypeptide binding]; other site 682795006994 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 682795006995 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 682795006996 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 682795006997 protein binding site [polypeptide binding]; other site 682795006998 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 682795006999 active site 682795007000 SAM binding site [chemical binding]; other site 682795007001 homodimer interface [polypeptide binding]; other site 682795007002 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 682795007003 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 682795007004 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 682795007005 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 682795007006 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 682795007007 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 682795007008 cofactor binding site; other site 682795007009 metal binding site [ion binding]; metal-binding site 682795007010 putative sialic acid transporter; Region: 2A0112; TIGR00891 682795007011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795007012 putative substrate translocation pore; other site 682795007013 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 682795007014 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 682795007015 carboxylate-amine ligase; Provisional; Region: PRK13515 682795007016 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 682795007017 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 682795007018 ATP-grasp domain; Region: ATP-grasp_4; cl17255 682795007019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 682795007020 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 682795007021 Putative esterase; Region: Esterase; pfam00756 682795007022 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 682795007023 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 682795007024 RimM N-terminal domain; Region: RimM; pfam01782 682795007025 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 682795007026 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 682795007027 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 682795007028 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 682795007029 RNA/DNA hybrid binding site [nucleotide binding]; other site 682795007030 active site 682795007031 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 682795007032 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 682795007033 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 682795007034 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 682795007035 Helix-turn-helix domain; Region: HTH_38; pfam13936 682795007036 Integrase core domain; Region: rve; pfam00665 682795007037 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 682795007038 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 682795007039 Walker A/P-loop; other site 682795007040 ATP binding site [chemical binding]; other site 682795007041 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 682795007042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795007043 Q-loop/lid; other site 682795007044 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 682795007045 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 682795007046 ABC transporter signature motif; other site 682795007047 Walker B; other site 682795007048 D-loop; other site 682795007049 H-loop/switch region; other site 682795007050 Colicin V production protein; Region: Colicin_V; pfam02674 682795007051 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 682795007052 Tetratricopeptide repeat; Region: TPR_16; pfam13432 682795007053 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 682795007054 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 682795007055 dinuclear metal binding motif [ion binding]; other site 682795007056 CCC1-related family of proteins; Region: CCC1_like; cl00278 682795007057 hypothetical protein; Provisional; Region: PRK06132 682795007058 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 682795007059 PAS domain; Region: PAS_9; pfam13426 682795007060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795007061 putative active site [active] 682795007062 heme pocket [chemical binding]; other site 682795007063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 682795007064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795007065 dimer interface [polypeptide binding]; other site 682795007066 phosphorylation site [posttranslational modification] 682795007067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795007068 ATP binding site [chemical binding]; other site 682795007069 Mg2+ binding site [ion binding]; other site 682795007070 G-X-G motif; other site 682795007071 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795007072 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 682795007073 ligand binding site [chemical binding]; other site 682795007074 flexible hinge region; other site 682795007075 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 682795007076 putative switch regulator; other site 682795007077 non-specific DNA interactions [nucleotide binding]; other site 682795007078 DNA binding site [nucleotide binding] 682795007079 sequence specific DNA binding site [nucleotide binding]; other site 682795007080 putative cAMP binding site [chemical binding]; other site 682795007081 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 682795007082 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 682795007083 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 682795007084 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 682795007085 active site 682795007086 catalytic site [active] 682795007087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 682795007088 Ligand Binding Site [chemical binding]; other site 682795007089 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 682795007090 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 682795007091 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 682795007092 Soluble P-type ATPase [General function prediction only]; Region: COG4087 682795007093 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 682795007094 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795007095 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 682795007096 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 682795007097 catalytic residues [active] 682795007098 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 682795007099 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 682795007100 putative NAD(P) binding site [chemical binding]; other site 682795007101 putative substrate binding site [chemical binding]; other site 682795007102 catalytic Zn binding site [ion binding]; other site 682795007103 structural Zn binding site [ion binding]; other site 682795007104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795007105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795007106 dimerization interface [polypeptide binding]; other site 682795007107 putative DNA binding site [nucleotide binding]; other site 682795007108 putative Zn2+ binding site [ion binding]; other site 682795007109 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 682795007110 benzoate transport; Region: 2A0115; TIGR00895 682795007111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795007112 putative substrate translocation pore; other site 682795007113 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 682795007114 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 682795007115 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 682795007116 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 682795007117 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 682795007118 Transcriptional regulators [Transcription]; Region: FadR; COG2186 682795007119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795007120 DNA-binding site [nucleotide binding]; DNA binding site 682795007121 FCD domain; Region: FCD; pfam07729 682795007122 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 682795007123 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 682795007124 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007125 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795007126 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795007127 acetolactate synthase; Reviewed; Region: PRK08617 682795007128 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 682795007129 PYR/PP interface [polypeptide binding]; other site 682795007130 dimer interface [polypeptide binding]; other site 682795007131 TPP binding site [chemical binding]; other site 682795007132 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 682795007133 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 682795007134 TPP-binding site [chemical binding]; other site 682795007135 dimer interface [polypeptide binding]; other site 682795007136 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 682795007137 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 682795007138 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 682795007139 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 682795007140 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 682795007141 FAD binding domain; Region: FAD_binding_4; pfam01565 682795007142 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 682795007143 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 682795007144 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795007145 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795007146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795007147 Outer membrane efflux protein; Region: OEP; pfam02321 682795007148 Outer membrane efflux protein; Region: OEP; pfam02321 682795007149 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 682795007150 MarR family; Region: MarR; pfam01047 682795007151 Isochorismatase family; Region: Isochorismatase; pfam00857 682795007152 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 682795007153 catalytic triad [active] 682795007154 conserved cis-peptide bond; other site 682795007155 H+ Antiporter protein; Region: 2A0121; TIGR00900 682795007156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795007157 putative substrate translocation pore; other site 682795007158 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 682795007159 Two component regulator propeller; Region: Reg_prop; pfam07494 682795007160 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 682795007161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 682795007162 Histidine kinase; Region: HisKA_3; pfam07730 682795007163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795007164 ATP binding site [chemical binding]; other site 682795007165 Mg2+ binding site [ion binding]; other site 682795007166 G-X-G motif; other site 682795007167 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 682795007168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795007169 active site 682795007170 phosphorylation site [posttranslational modification] 682795007171 intermolecular recognition site; other site 682795007172 dimerization interface [polypeptide binding]; other site 682795007173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795007174 DNA binding residues [nucleotide binding] 682795007175 dimerization interface [polypeptide binding]; other site 682795007176 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 682795007177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795007178 active site 682795007179 phosphorylation site [posttranslational modification] 682795007180 intermolecular recognition site; other site 682795007181 dimerization interface [polypeptide binding]; other site 682795007182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795007183 DNA binding residues [nucleotide binding] 682795007184 dimerization interface [polypeptide binding]; other site 682795007185 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 682795007186 NHL repeat; Region: NHL; pfam01436 682795007187 NHL repeat; Region: NHL; pfam01436 682795007188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795007189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795007190 DNA binding site [nucleotide binding] 682795007191 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 682795007192 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 682795007193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007194 binding surface 682795007195 TPR motif; other site 682795007196 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 682795007197 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 682795007198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795007199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795007200 DNA binding site [nucleotide binding] 682795007201 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 682795007202 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 682795007203 structural tetrad; other site 682795007204 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 682795007205 structural tetrad; other site 682795007206 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 682795007207 catalytic residues [active] 682795007208 dimer interface [polypeptide binding]; other site 682795007209 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 682795007210 Peptidase family M23; Region: Peptidase_M23; pfam01551 682795007211 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007212 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795007213 FOG: WD40 repeat [General function prediction only]; Region: COG2319 682795007214 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 682795007215 structural tetrad; other site 682795007216 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 682795007217 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795007218 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 682795007219 Interdomain contacts; other site 682795007220 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795007221 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795007222 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 682795007223 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 682795007224 putative NAD(P) binding site [chemical binding]; other site 682795007225 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 682795007226 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 682795007227 active site 682795007228 ATP binding site [chemical binding]; other site 682795007229 substrate binding site [chemical binding]; other site 682795007230 activation loop (A-loop); other site 682795007231 PAAR motif; Region: PAAR_motif; pfam05488 682795007232 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 682795007233 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 682795007234 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 682795007235 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 682795007236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795007237 Walker A motif; other site 682795007238 ATP binding site [chemical binding]; other site 682795007239 Walker B motif; other site 682795007240 arginine finger; other site 682795007241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795007242 Walker A motif; other site 682795007243 ATP binding site [chemical binding]; other site 682795007244 Walker B motif; other site 682795007245 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 682795007246 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 682795007247 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 682795007248 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 682795007249 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 682795007250 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 682795007251 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 682795007252 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 682795007253 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 682795007254 ImpE protein; Region: ImpE; pfam07024 682795007255 Protein of unknown function (DUF796); Region: DUF796; cl01226 682795007256 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 682795007257 Protein of unknown function (DUF877); Region: DUF877; pfam05943 682795007258 Protein of unknown function (DUF770); Region: DUF770; pfam05591 682795007259 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 682795007260 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 682795007261 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 682795007262 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 682795007263 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 682795007264 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 682795007265 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 682795007266 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 682795007267 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 682795007268 Protein phosphatase 2C; Region: PP2C; pfam00481 682795007269 active site 682795007270 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 682795007271 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 682795007272 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 682795007273 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 682795007274 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 682795007275 Cytochrome c; Region: Cytochrom_C; cl11414 682795007276 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 682795007277 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 682795007278 D-pathway; other site 682795007279 Putative ubiquinol binding site [chemical binding]; other site 682795007280 Low-spin heme (heme b) binding site [chemical binding]; other site 682795007281 Putative water exit pathway; other site 682795007282 Binuclear center (heme o3/CuB) [ion binding]; other site 682795007283 K-pathway; other site 682795007284 Putative proton exit pathway; other site 682795007285 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 682795007286 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 682795007287 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 682795007288 Cytochrome c; Region: Cytochrom_C; pfam00034 682795007289 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 682795007290 iron-sulfur cluster [ion binding]; other site 682795007291 [2Fe-2S] cluster binding site [ion binding]; other site 682795007292 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 682795007293 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 682795007294 heme bH binding site [chemical binding]; other site 682795007295 intrachain domain interface; other site 682795007296 Qi binding site; other site 682795007297 heme bL binding site [chemical binding]; other site 682795007298 interchain domain interface [polypeptide binding]; other site 682795007299 Qo binding site; other site 682795007300 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 682795007301 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 682795007302 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 682795007303 active site 682795007304 DNA binding site [nucleotide binding] 682795007305 Uncharacterized conserved protein [Function unknown]; Region: COG3189 682795007306 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007307 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795007308 CHASE3 domain; Region: CHASE3; pfam05227 682795007309 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 682795007310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795007311 putative active site [active] 682795007312 heme pocket [chemical binding]; other site 682795007313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795007314 dimer interface [polypeptide binding]; other site 682795007315 phosphorylation site [posttranslational modification] 682795007316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795007317 ATP binding site [chemical binding]; other site 682795007318 Mg2+ binding site [ion binding]; other site 682795007319 G-X-G motif; other site 682795007320 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 682795007321 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 682795007322 Zn2+ binding site [ion binding]; other site 682795007323 Mg2+ binding site [ion binding]; other site 682795007324 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007325 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795007326 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 682795007327 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 682795007328 alpha-galactosidase; Region: PLN02808; cl17638 682795007329 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 682795007330 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 682795007331 active site 682795007332 catalytic residues [active] 682795007333 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 682795007334 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 682795007335 intersubunit interface [polypeptide binding]; other site 682795007336 active site 682795007337 Zn2+ binding site [ion binding]; other site 682795007338 L-arabinose isomerase; Provisional; Region: PRK02929 682795007339 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 682795007340 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 682795007341 trimer interface [polypeptide binding]; other site 682795007342 putative substrate binding site [chemical binding]; other site 682795007343 putative metal binding site [ion binding]; other site 682795007344 ribulokinase; Provisional; Region: PRK04123 682795007345 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 682795007346 nucleotide binding site [chemical binding]; other site 682795007347 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795007348 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795007349 DNA binding site [nucleotide binding] 682795007350 domain linker motif; other site 682795007351 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795007352 dimerization interface [polypeptide binding]; other site 682795007353 ligand binding site [chemical binding]; other site 682795007354 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 682795007355 substrate binding site [chemical binding]; other site 682795007356 active site 682795007357 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007358 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795007359 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 682795007360 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795007361 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795007362 active site 682795007363 metal binding site [ion binding]; metal-binding site 682795007364 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795007365 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795007366 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795007367 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795007368 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 682795007369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795007370 ATP binding site [chemical binding]; other site 682795007371 putative Mg++ binding site [ion binding]; other site 682795007372 nucleotide binding region [chemical binding]; other site 682795007373 helicase superfamily c-terminal domain; Region: HELICc; smart00490 682795007374 ATP-binding site [chemical binding]; other site 682795007375 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 682795007376 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 682795007377 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795007378 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 682795007379 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 682795007380 putative switch regulator; other site 682795007381 non-specific DNA interactions [nucleotide binding]; other site 682795007382 DNA binding site [nucleotide binding] 682795007383 sequence specific DNA binding site [nucleotide binding]; other site 682795007384 putative cAMP binding site [chemical binding]; other site 682795007385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 682795007386 phosphorylation site [posttranslational modification] 682795007387 dimer interface [polypeptide binding]; other site 682795007388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795007389 ATP binding site [chemical binding]; other site 682795007390 Mg2+ binding site [ion binding]; other site 682795007391 G-X-G motif; other site 682795007392 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795007393 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 682795007394 ligand binding site [chemical binding]; other site 682795007395 flexible hinge region; other site 682795007396 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 682795007397 putative switch regulator; other site 682795007398 non-specific DNA interactions [nucleotide binding]; other site 682795007399 DNA binding site [nucleotide binding] 682795007400 sequence specific DNA binding site [nucleotide binding]; other site 682795007401 putative cAMP binding site [chemical binding]; other site 682795007402 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 682795007403 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 682795007404 active site 682795007405 DNA binding site [nucleotide binding] 682795007406 Int/Topo IB signature motif; other site 682795007407 catalytic residues [active] 682795007408 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 682795007409 iron-sulfur cluster [ion binding]; other site 682795007410 [2Fe-2S] cluster binding site [ion binding]; other site 682795007411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 682795007412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795007413 Response regulator receiver domain; Region: Response_reg; pfam00072 682795007414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795007415 active site 682795007416 phosphorylation site [posttranslational modification] 682795007417 intermolecular recognition site; other site 682795007418 dimerization interface [polypeptide binding]; other site 682795007419 Purine nucleoside permease (NUP); Region: NUP; cl17832 682795007420 membrane protein insertase; Provisional; Region: PRK01318 682795007421 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 682795007422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795007423 metabolite-proton symporter; Region: 2A0106; TIGR00883 682795007424 putative substrate translocation pore; other site 682795007425 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 682795007426 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 682795007427 conserved cys residue [active] 682795007428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795007429 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 682795007430 Zn2+ binding site [ion binding]; other site 682795007431 Mg2+ binding site [ion binding]; other site 682795007432 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007433 Outer membrane efflux protein; Region: OEP; pfam02321 682795007434 Outer membrane efflux protein; Region: OEP; pfam02321 682795007435 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795007436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795007437 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795007438 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 682795007439 Protein export membrane protein; Region: SecD_SecF; cl14618 682795007440 Protein export membrane protein; Region: SecD_SecF; cl14618 682795007441 Uncharacterized conserved protein [Function unknown]; Region: COG3391 682795007442 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795007443 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795007444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 682795007445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795007446 dimer interface [polypeptide binding]; other site 682795007447 phosphorylation site [posttranslational modification] 682795007448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795007449 ATP binding site [chemical binding]; other site 682795007450 Mg2+ binding site [ion binding]; other site 682795007451 G-X-G motif; other site 682795007452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795007453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795007454 active site 682795007455 phosphorylation site [posttranslational modification] 682795007456 intermolecular recognition site; other site 682795007457 dimerization interface [polypeptide binding]; other site 682795007458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795007459 DNA binding site [nucleotide binding] 682795007460 Right handed beta helix region; Region: Beta_helix; pfam13229 682795007461 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 682795007462 Interdomain contacts; other site 682795007463 Cytokine receptor motif; other site 682795007464 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 682795007465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795007466 putative substrate translocation pore; other site 682795007467 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 682795007468 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 682795007469 putative active site pocket [active] 682795007470 metal binding site [ion binding]; metal-binding site 682795007471 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 682795007472 classical (c) SDRs; Region: SDR_c; cd05233 682795007473 NAD(P) binding site [chemical binding]; other site 682795007474 active site 682795007475 short chain dehydrogenase; Provisional; Region: PRK08628 682795007476 classical (c) SDRs; Region: SDR_c; cd05233 682795007477 NAD(P) binding site [chemical binding]; other site 682795007478 active site 682795007479 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 682795007480 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 682795007481 active site 682795007482 TDP-binding site; other site 682795007483 acceptor substrate-binding pocket; other site 682795007484 Predicted esterase [General function prediction only]; Region: COG0400 682795007485 putative hydrolase; Provisional; Region: PRK11460 682795007486 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 682795007487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795007488 Zn binding site [ion binding]; other site 682795007489 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 682795007490 Zn binding site [ion binding]; other site 682795007491 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 682795007492 Na binding site [ion binding]; other site 682795007493 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 682795007494 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 682795007495 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 682795007496 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 682795007497 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 682795007498 dimer interface [polypeptide binding]; other site 682795007499 active site 682795007500 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 682795007501 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 682795007502 NAD binding site [chemical binding]; other site 682795007503 homodimer interface [polypeptide binding]; other site 682795007504 active site 682795007505 substrate binding site [chemical binding]; other site 682795007506 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 682795007507 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 682795007508 Cl- selectivity filter; other site 682795007509 Cl- binding residues [ion binding]; other site 682795007510 pore gating glutamate residue; other site 682795007511 dimer interface [polypeptide binding]; other site 682795007512 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007513 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 682795007514 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 682795007515 N-terminal plug; other site 682795007516 ligand-binding site [chemical binding]; other site 682795007517 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 682795007518 Septum formation initiator; Region: DivIC; pfam04977 682795007519 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 682795007520 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 682795007521 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 682795007522 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 682795007523 core dimer interface [polypeptide binding]; other site 682795007524 L11 interface [polypeptide binding]; other site 682795007525 putative EF-Tu interaction site [polypeptide binding]; other site 682795007526 putative EF-G interaction site [polypeptide binding]; other site 682795007527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 682795007528 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 682795007529 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 682795007530 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 682795007531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 682795007532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 682795007533 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 682795007534 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 682795007535 catalytic residue [active] 682795007536 Phage terminase large subunit; Region: Terminase_3; cl12054 682795007537 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 682795007538 non-specific DNA interactions [nucleotide binding]; other site 682795007539 DNA binding site [nucleotide binding] 682795007540 sequence specific DNA binding site [nucleotide binding]; other site 682795007541 putative cAMP binding site [chemical binding]; other site 682795007542 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 682795007543 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 682795007544 putative NAD(P) binding site [chemical binding]; other site 682795007545 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 682795007546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795007547 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 682795007548 putative active site [active] 682795007549 heme pocket [chemical binding]; other site 682795007550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795007551 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 682795007552 putative active site [active] 682795007553 heme pocket [chemical binding]; other site 682795007554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795007555 dimer interface [polypeptide binding]; other site 682795007556 phosphorylation site [posttranslational modification] 682795007557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795007558 ATP binding site [chemical binding]; other site 682795007559 Mg2+ binding site [ion binding]; other site 682795007560 G-X-G motif; other site 682795007561 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 682795007562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795007563 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795007564 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795007565 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795007566 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795007567 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795007568 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795007569 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 682795007570 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 682795007571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795007572 FeS/SAM binding site; other site 682795007573 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 682795007574 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 682795007575 catalytic residue [active] 682795007576 putative FPP diphosphate binding site; other site 682795007577 putative FPP binding hydrophobic cleft; other site 682795007578 dimer interface [polypeptide binding]; other site 682795007579 putative IPP diphosphate binding site; other site 682795007580 Transcriptional regulators [Transcription]; Region: MarR; COG1846 682795007581 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 682795007582 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 682795007583 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 682795007584 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795007585 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795007586 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795007587 Response regulator receiver domain; Region: Response_reg; pfam00072 682795007588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795007589 active site 682795007590 phosphorylation site [posttranslational modification] 682795007591 intermolecular recognition site; other site 682795007592 dimerization interface [polypeptide binding]; other site 682795007593 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 682795007594 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 682795007595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 682795007596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795007597 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795007598 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 682795007599 ligand binding site [chemical binding]; other site 682795007600 flexible hinge region; other site 682795007601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 682795007602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795007603 ATP binding site [chemical binding]; other site 682795007604 Mg2+ binding site [ion binding]; other site 682795007605 G-X-G motif; other site 682795007606 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 682795007607 putative substrate binding site [chemical binding]; other site 682795007608 active site 682795007609 Nitronate monooxygenase; Region: NMO; pfam03060 682795007610 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 682795007611 FMN binding site [chemical binding]; other site 682795007612 substrate binding site [chemical binding]; other site 682795007613 putative catalytic residue [active] 682795007614 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795007615 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 682795007616 structural tetrad; other site 682795007617 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795007618 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 682795007619 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 682795007620 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 682795007621 protein binding site [polypeptide binding]; other site 682795007622 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 682795007623 Domain interface; other site 682795007624 Peptide binding site; other site 682795007625 Active site tetrad [active] 682795007626 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 682795007627 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 682795007628 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795007629 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795007630 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 682795007631 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 682795007632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795007633 non-specific DNA binding site [nucleotide binding]; other site 682795007634 salt bridge; other site 682795007635 sequence-specific DNA binding site [nucleotide binding]; other site 682795007636 Predicted transcriptional regulator [Transcription]; Region: COG2932 682795007637 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 682795007638 Catalytic site [active] 682795007639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795007640 DNA binding site [nucleotide binding] 682795007641 Predicted integral membrane protein [Function unknown]; Region: COG5616 682795007642 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007643 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 682795007644 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795007645 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 682795007646 active site 682795007647 DNA binding site [nucleotide binding] 682795007648 Int/Topo IB signature motif; other site 682795007649 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795007650 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 682795007651 active site 682795007652 DNA binding site [nucleotide binding] 682795007653 Int/Topo IB signature motif; other site 682795007654 signal recognition particle protein; Provisional; Region: PRK10867 682795007655 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 682795007656 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 682795007657 P loop; other site 682795007658 GTP binding site [chemical binding]; other site 682795007659 Signal peptide binding domain; Region: SRP_SPB; pfam02978 682795007660 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 682795007661 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 682795007662 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 682795007663 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 682795007664 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 682795007665 substrate binding pocket [chemical binding]; other site 682795007666 catalytic triad [active] 682795007667 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 682795007668 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 682795007669 putative catalytic residues [active] 682795007670 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795007671 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 682795007672 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 682795007673 active site 682795007674 dimer interface [polypeptide binding]; other site 682795007675 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 682795007676 dimer interface [polypeptide binding]; other site 682795007677 active site 682795007678 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 682795007679 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 682795007680 Bacterial transcriptional regulator; Region: IclR; pfam01614 682795007681 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 682795007682 phosphoglycolate phosphatase; Provisional; Region: PRK13222 682795007683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795007684 motif II; other site 682795007685 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 682795007686 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 682795007687 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 682795007688 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 682795007689 LexA repressor; Validated; Region: PRK00215 682795007690 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 682795007691 Catalytic site [active] 682795007692 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 682795007693 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 682795007694 16S/18S rRNA binding site [nucleotide binding]; other site 682795007695 S13e-L30e interaction site [polypeptide binding]; other site 682795007696 25S rRNA binding site [nucleotide binding]; other site 682795007697 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 682795007698 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 682795007699 RNase E interface [polypeptide binding]; other site 682795007700 trimer interface [polypeptide binding]; other site 682795007701 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 682795007702 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 682795007703 RNase E interface [polypeptide binding]; other site 682795007704 trimer interface [polypeptide binding]; other site 682795007705 active site 682795007706 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 682795007707 putative nucleic acid binding region [nucleotide binding]; other site 682795007708 G-X-X-G motif; other site 682795007709 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 682795007710 RNA binding site [nucleotide binding]; other site 682795007711 domain interface; other site 682795007712 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 682795007713 DinB superfamily; Region: DinB_2; pfam12867 682795007714 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 682795007715 fructokinase; Reviewed; Region: PRK09557 682795007716 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 682795007717 nucleotide binding site [chemical binding]; other site 682795007718 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795007719 peptidase domain interface [polypeptide binding]; other site 682795007720 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795007721 active site 682795007722 catalytic triad [active] 682795007723 calcium binding site [ion binding]; other site 682795007724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795007725 DNA binding site [nucleotide binding] 682795007726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007727 TPR repeat; Region: TPR_11; pfam13414 682795007728 binding surface 682795007729 TPR motif; other site 682795007730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 682795007731 TPR motif; other site 682795007732 binding surface 682795007733 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 682795007734 MgtC family; Region: MgtC; pfam02308 682795007735 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 682795007736 active site 682795007737 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 682795007738 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 682795007739 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 682795007740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795007741 S-adenosylmethionine binding site [chemical binding]; other site 682795007742 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 682795007743 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795007744 peptidase domain interface [polypeptide binding]; other site 682795007745 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795007746 active site 682795007747 catalytic triad [active] 682795007748 calcium binding site [ion binding]; other site 682795007749 YbbR-like protein; Region: YbbR; pfam07949 682795007750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795007751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795007752 DNA binding site [nucleotide binding] 682795007753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007754 TPR motif; other site 682795007755 binding surface 682795007756 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 682795007757 putative active site [active] 682795007758 catalytic site [active] 682795007759 putative metal binding site [ion binding]; other site 682795007760 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 682795007761 active site 682795007762 metal binding site [ion binding]; metal-binding site 682795007763 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795007764 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007765 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795007766 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795007767 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 682795007768 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 682795007769 Sulfate transporter family; Region: Sulfate_transp; pfam00916 682795007770 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 682795007771 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 682795007772 Mechanosensitive ion channel; Region: MS_channel; pfam00924 682795007773 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 682795007774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795007775 DNA-binding site [nucleotide binding]; DNA binding site 682795007776 UTRA domain; Region: UTRA; pfam07702 682795007777 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 682795007778 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 682795007779 Chromate transporter; Region: Chromate_transp; pfam02417 682795007780 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007781 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 682795007782 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 682795007783 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 682795007784 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 682795007785 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 682795007786 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 682795007787 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 682795007788 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 682795007789 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 682795007790 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 682795007791 metal ion-dependent adhesion site (MIDAS); other site 682795007792 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 682795007793 homotrimer interface [polypeptide binding]; other site 682795007794 Walker A motif; other site 682795007795 GTP binding site [chemical binding]; other site 682795007796 Walker B motif; other site 682795007797 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 682795007798 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 682795007799 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 682795007800 catalytic triad [active] 682795007801 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 682795007802 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 682795007803 putative dimer interface [polypeptide binding]; other site 682795007804 active site pocket [active] 682795007805 putative cataytic base [active] 682795007806 cobalamin synthase; Reviewed; Region: cobS; PRK00235 682795007807 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 682795007808 catalytic core [active] 682795007809 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 682795007810 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 682795007811 putative FMN binding site [chemical binding]; other site 682795007812 cobyric acid synthase; Provisional; Region: PRK00784 682795007813 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795007814 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795007815 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 682795007816 catalytic triad [active] 682795007817 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 682795007818 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 682795007819 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795007820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795007821 homodimer interface [polypeptide binding]; other site 682795007822 catalytic residue [active] 682795007823 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 682795007824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795007825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795007826 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795007827 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795007828 active site 682795007829 catalytic tetrad [active] 682795007830 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 682795007831 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 682795007832 RNA binding site [nucleotide binding]; other site 682795007833 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 682795007834 RNA binding site [nucleotide binding]; other site 682795007835 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 682795007836 RNA binding site [nucleotide binding]; other site 682795007837 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 682795007838 RNA binding site [nucleotide binding]; other site 682795007839 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 682795007840 RNA binding site [nucleotide binding]; other site 682795007841 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795007842 peptidase domain interface [polypeptide binding]; other site 682795007843 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 682795007844 active site 682795007845 catalytic residues [active] 682795007846 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 682795007847 catalytic residues [active] 682795007848 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 682795007849 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 682795007850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 682795007851 Histidine kinase; Region: HisKA_3; pfam07730 682795007852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795007853 ATP binding site [chemical binding]; other site 682795007854 Mg2+ binding site [ion binding]; other site 682795007855 G-X-G motif; other site 682795007856 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 682795007857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795007858 active site 682795007859 phosphorylation site [posttranslational modification] 682795007860 intermolecular recognition site; other site 682795007861 dimerization interface [polypeptide binding]; other site 682795007862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795007863 DNA binding residues [nucleotide binding] 682795007864 dimerization interface [polypeptide binding]; other site 682795007865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795007866 DNA binding site [nucleotide binding] 682795007867 Predicted integral membrane protein [Function unknown]; Region: COG5616 682795007868 TPR repeat; Region: TPR_11; pfam13414 682795007869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007870 binding surface 682795007871 TPR motif; other site 682795007872 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 682795007873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007874 TPR motif; other site 682795007875 binding surface 682795007876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007877 binding surface 682795007878 TPR motif; other site 682795007879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007880 binding surface 682795007881 TPR motif; other site 682795007882 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007883 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 682795007884 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 682795007885 active site 682795007886 catalytic site [active] 682795007887 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 682795007888 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 682795007889 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795007890 peptidase domain interface [polypeptide binding]; other site 682795007891 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795007892 active site 682795007893 catalytic triad [active] 682795007894 calcium binding site [ion binding]; other site 682795007895 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795007896 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795007897 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795007898 Uncharacterized conserved protein [Function unknown]; Region: COG1262 682795007899 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 682795007900 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 682795007901 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 682795007902 substrate binding site [chemical binding]; other site 682795007903 dimer interface [polypeptide binding]; other site 682795007904 ATP binding site [chemical binding]; other site 682795007905 Ureide permease; Region: Ureide_permease; pfam07168 682795007906 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795007908 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795007909 DNA binding site [nucleotide binding] 682795007910 domain linker motif; other site 682795007911 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795007912 dimerization interface [polypeptide binding]; other site 682795007913 ligand binding site [chemical binding]; other site 682795007914 Transcriptional regulator [Transcription]; Region: IclR; COG1414 682795007915 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 682795007916 Bacterial transcriptional regulator; Region: IclR; pfam01614 682795007917 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 682795007918 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 682795007919 CoA-transferase family III; Region: CoA_transf_3; pfam02515 682795007920 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 682795007921 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795007922 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795007923 active site 682795007924 catalytic triad [active] 682795007925 calcium binding site [ion binding]; other site 682795007926 Family description; Region: VCBS; pfam13517 682795007927 Family description; Region: VCBS; pfam13517 682795007928 Family description; Region: VCBS; pfam13517 682795007929 Family description; Region: VCBS; pfam13517 682795007930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795007931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795007932 DNA binding site [nucleotide binding] 682795007933 TPR repeat; Region: TPR_11; pfam13414 682795007934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007935 TPR motif; other site 682795007936 binding surface 682795007937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795007938 binding surface 682795007939 TPR motif; other site 682795007940 Uncharacterized conserved protein [Function unknown]; Region: COG5649 682795007941 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 682795007942 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 682795007943 NADP binding site [chemical binding]; other site 682795007944 dimer interface [polypeptide binding]; other site 682795007945 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795007946 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 682795007947 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 682795007948 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007949 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 682795007950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795007951 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 682795007952 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 682795007953 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 682795007954 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 682795007955 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 682795007956 Uncharacterized conserved protein [Function unknown]; Region: COG3391 682795007957 Cupin domain; Region: Cupin_2; pfam07883 682795007958 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795007959 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795007960 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007961 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795007962 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 682795007963 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 682795007964 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 682795007965 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 682795007966 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795007967 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 682795007968 active site 682795007969 metal binding site [ion binding]; metal-binding site 682795007970 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 682795007971 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795007972 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 682795007973 TrwC relaxase; Region: TrwC; pfam08751 682795007974 AAA domain; Region: AAA_30; pfam13604 682795007975 Family description; Region: UvrD_C_2; pfam13538 682795007976 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 682795007977 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 682795007978 Walker A motif; other site 682795007979 ATP binding site [chemical binding]; other site 682795007980 Walker B motif; other site 682795007981 RNA polymerase sigma factor; Provisional; Region: PRK12519 682795007982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795007983 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 682795007984 Anti-sigma-K factor rskA; Region: RskA; pfam10099 682795007985 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795007986 active site 682795007987 DNA binding site [nucleotide binding] 682795007988 Int/Topo IB signature motif; other site 682795007989 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 682795007990 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 682795007991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795007992 active site 682795007993 DNA binding site [nucleotide binding] 682795007994 Int/Topo IB signature motif; other site 682795007995 Uncharacterized conserved protein [Function unknown]; Region: COG2135 682795007996 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 682795007997 Walker A motif; other site 682795007998 ATP binding site [chemical binding]; other site 682795007999 DNA Polymerase Y-family; Region: PolY_like; cd03468 682795008000 active site 682795008001 DNA binding site [nucleotide binding] 682795008002 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 682795008003 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 682795008004 active site 682795008005 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 682795008006 generic binding surface II; other site 682795008007 generic binding surface I; other site 682795008008 AAA domain; Region: AAA_21; pfam13304 682795008009 AAA domain; Region: AAA_21; pfam13304 682795008010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795008011 Q-loop/lid; other site 682795008012 ABC transporter signature motif; other site 682795008013 Walker B; other site 682795008014 D-loop; other site 682795008015 H-loop/switch region; other site 682795008016 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 682795008017 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 682795008018 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 682795008019 HsdM N-terminal domain; Region: HsdM_N; pfam12161 682795008020 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 682795008021 Methyltransferase domain; Region: Methyltransf_26; pfam13659 682795008022 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 682795008023 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 682795008024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795008025 ATP binding site [chemical binding]; other site 682795008026 putative Mg++ binding site [ion binding]; other site 682795008027 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795008028 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 682795008029 active site 682795008030 catalytic residues [active] 682795008031 DNA binding site [nucleotide binding] 682795008032 Int/Topo IB signature motif; other site 682795008033 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 682795008034 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 682795008035 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 682795008036 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 682795008037 N-acetyl-D-glucosamine binding site [chemical binding]; other site 682795008038 catalytic residue [active] 682795008039 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795008040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795008041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795008042 DNA binding residues [nucleotide binding] 682795008043 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 682795008044 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 682795008045 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 682795008046 Formiminotransferase domain; Region: FTCD; pfam02971 682795008047 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 682795008048 hypothetical protein; Validated; Region: PRK00110 682795008049 Predicted transcriptional regulator [Transcription]; Region: COG3905 682795008050 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 682795008051 diaminopimelate decarboxylase; Region: lysA; TIGR01048 682795008052 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 682795008053 active site 682795008054 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 682795008055 substrate binding site [chemical binding]; other site 682795008056 catalytic residues [active] 682795008057 dimer interface [polypeptide binding]; other site 682795008058 PspC domain; Region: PspC; pfam04024 682795008059 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008060 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 682795008061 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795008062 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795008063 metal ion-dependent adhesion site (MIDAS); other site 682795008064 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 682795008065 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795008066 FtsX-like permease family; Region: FtsX; pfam02687 682795008067 Transposase domain (DUF772); Region: DUF772; pfam05598 682795008068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 682795008069 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 682795008070 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 682795008071 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 682795008072 Walker A/P-loop; other site 682795008073 ATP binding site [chemical binding]; other site 682795008074 Q-loop/lid; other site 682795008075 ABC transporter signature motif; other site 682795008076 Walker B; other site 682795008077 D-loop; other site 682795008078 H-loop/switch region; other site 682795008079 Pectate lyase; Region: Pec_lyase_C; cl01593 682795008080 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 682795008081 Peptidase family M23; Region: Peptidase_M23; pfam01551 682795008082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 682795008083 Beta-lactamase; Region: Beta-lactamase; pfam00144 682795008084 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 682795008085 Clp amino terminal domain; Region: Clp_N; pfam02861 682795008086 Clp amino terminal domain; Region: Clp_N; pfam02861 682795008087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795008088 Walker A motif; other site 682795008089 ATP binding site [chemical binding]; other site 682795008090 Walker B motif; other site 682795008091 arginine finger; other site 682795008092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795008093 Walker A motif; other site 682795008094 ATP binding site [chemical binding]; other site 682795008095 Walker B motif; other site 682795008096 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 682795008097 Cupin domain; Region: Cupin_2; pfam07883 682795008098 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 682795008099 Fe-S cluster binding site [ion binding]; other site 682795008100 DNA binding site [nucleotide binding] 682795008101 active site 682795008102 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 682795008103 active site 682795008104 catalytic residues [active] 682795008105 trigger factor; Region: tig; TIGR00115 682795008106 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 682795008107 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 682795008108 Clp protease; Region: CLP_protease; pfam00574 682795008109 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 682795008110 oligomer interface [polypeptide binding]; other site 682795008111 active site residues [active] 682795008112 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 682795008113 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 682795008114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795008115 Walker A motif; other site 682795008116 ATP binding site [chemical binding]; other site 682795008117 Walker B motif; other site 682795008118 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 682795008119 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 682795008120 Found in ATP-dependent protease La (LON); Region: LON; smart00464 682795008121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795008122 Walker A motif; other site 682795008123 ATP binding site [chemical binding]; other site 682795008124 Walker B motif; other site 682795008125 arginine finger; other site 682795008126 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 682795008127 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 682795008128 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795008129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795008130 homodimer interface [polypeptide binding]; other site 682795008131 catalytic residue [active] 682795008132 soil-associated protein, TIGR03435 family; Region: Soli_TIGR03435 682795008133 Ubiquitin-like proteins; Region: UBQ; cl00155 682795008134 charged pocket; other site 682795008135 hydrophobic patch; other site 682795008136 threonine synthase; Validated; Region: PRK07591 682795008137 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 682795008138 homodimer interface [polypeptide binding]; other site 682795008139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795008140 catalytic residue [active] 682795008141 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 682795008142 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 682795008143 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 682795008144 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795008145 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795008146 Uncharacterized conserved protein [Function unknown]; Region: COG3391 682795008147 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 682795008148 epoxyqueuosine reductase; Region: TIGR00276 682795008149 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 682795008150 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 682795008151 heat shock protein 90; Provisional; Region: PRK05218 682795008152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795008153 ATP binding site [chemical binding]; other site 682795008154 Mg2+ binding site [ion binding]; other site 682795008155 G-X-G motif; other site 682795008156 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 682795008157 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795008158 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 682795008159 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 682795008160 active site 682795008161 TDP-binding site; other site 682795008162 acceptor substrate-binding pocket; other site 682795008163 homodimer interface [polypeptide binding]; other site 682795008164 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 682795008165 Helix-turn-helix domain; Region: HTH_38; pfam13936 682795008166 Integrase core domain; Region: rve; pfam00665 682795008167 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008168 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 682795008169 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 682795008170 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 682795008171 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 682795008172 substrate binding pocket [chemical binding]; other site 682795008173 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 682795008174 B12 binding site [chemical binding]; other site 682795008175 cobalt ligand [ion binding]; other site 682795008176 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 682795008177 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 682795008178 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 682795008179 Protein of unknown function (DUF763); Region: DUF763; pfam05559 682795008180 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 682795008181 active site 682795008182 DNA polymerase IV; Validated; Region: PRK02406 682795008183 DNA binding site [nucleotide binding] 682795008184 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 682795008185 nudix motif; other site 682795008186 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008187 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795008188 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795008189 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795008190 Fn3 associated; Region: Fn3_assoc; pfam13287 682795008191 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008192 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 682795008193 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795008194 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795008195 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795008196 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 682795008197 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 682795008198 homodimer interface [polypeptide binding]; other site 682795008199 active site 682795008200 TDP-binding site; other site 682795008201 acceptor substrate-binding pocket; other site 682795008202 hypothetical protein; Validated; Region: PRK00029 682795008203 Uncharacterized conserved protein [Function unknown]; Region: COG0397 682795008204 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 682795008205 active site 682795008206 catalytic residues [active] 682795008207 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 682795008208 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 682795008209 putative sugar binding sites [chemical binding]; other site 682795008210 Q-X-W motif; other site 682795008211 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008212 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 682795008213 Sulfatase; Region: Sulfatase; pfam00884 682795008214 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 682795008215 substrate binding pocket [chemical binding]; other site 682795008216 substrate-Mg2+ binding site; other site 682795008217 aspartate-rich region 1; other site 682795008218 aspartate-rich region 2; other site 682795008219 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795008220 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795008221 DNA binding site [nucleotide binding] 682795008222 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 682795008223 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795008224 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795008225 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795008226 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 682795008227 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795008228 active site 682795008229 metal binding site [ion binding]; metal-binding site 682795008230 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 682795008232 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 682795008233 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 682795008234 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 682795008235 PAAR motif; Region: PAAR_motif; pfam05488 682795008236 RHS Repeat; Region: RHS_repeat; cl11982 682795008237 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 682795008238 RHS Repeat; Region: RHS_repeat; pfam05593 682795008239 RHS Repeat; Region: RHS_repeat; pfam05593 682795008240 RHS Repeat; Region: RHS_repeat; pfam05593 682795008241 RHS Repeat; Region: RHS_repeat; pfam05593 682795008242 RHS Repeat; Region: RHS_repeat; pfam05593 682795008243 RHS Repeat; Region: RHS_repeat; cl11982 682795008244 RHS Repeat; Region: RHS_repeat; pfam05593 682795008245 RHS protein; Region: RHS; pfam03527 682795008246 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 682795008247 Condensation domain; Region: Condensation; pfam00668 682795008248 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 682795008249 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795008250 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795008251 acyl-activating enzyme (AAE) consensus motif; other site 682795008252 AMP binding site [chemical binding]; other site 682795008253 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008254 Condensation domain; Region: Condensation; pfam00668 682795008255 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795008256 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 682795008257 acyl-activating enzyme (AAE) consensus motif; other site 682795008258 AMP binding site [chemical binding]; other site 682795008259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008260 Condensation domain; Region: Condensation; pfam00668 682795008261 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795008262 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 682795008263 acyl-activating enzyme (AAE) consensus motif; other site 682795008264 AMP binding site [chemical binding]; other site 682795008265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008266 Condensation domain; Region: Condensation; pfam00668 682795008267 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 682795008268 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795008269 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795008270 acyl-activating enzyme (AAE) consensus motif; other site 682795008271 AMP binding site [chemical binding]; other site 682795008272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008273 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 682795008274 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795008275 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 682795008276 acyl-activating enzyme (AAE) consensus motif; other site 682795008277 AMP binding site [chemical binding]; other site 682795008278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008279 Condensation domain; Region: Condensation; pfam00668 682795008280 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 682795008281 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795008282 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 682795008283 acyl-activating enzyme (AAE) consensus motif; other site 682795008284 AMP binding site [chemical binding]; other site 682795008285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008286 Condensation domain; Region: Condensation; pfam00668 682795008287 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 682795008288 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795008289 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795008290 acyl-activating enzyme (AAE) consensus motif; other site 682795008291 AMP binding site [chemical binding]; other site 682795008292 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008293 Condensation domain; Region: Condensation; pfam00668 682795008294 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 682795008295 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 682795008296 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 682795008297 substrate-cofactor binding pocket; other site 682795008298 homodimer interface [polypeptide binding]; other site 682795008299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795008300 catalytic residue [active] 682795008301 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 682795008302 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 682795008303 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 682795008304 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 682795008305 Glutamine amidotransferase class-I; Region: GATase; pfam00117 682795008306 glutamine binding [chemical binding]; other site 682795008307 catalytic triad [active] 682795008308 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 682795008309 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 682795008310 active site 682795008311 Acyl transferase domain; Region: Acyl_transf_1; cl08282 682795008312 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 682795008313 KR domain; Region: KR; pfam08659 682795008314 putative NADP binding site [chemical binding]; other site 682795008315 active site 682795008316 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 682795008317 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 682795008318 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 682795008319 active site 682795008320 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 682795008321 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 682795008322 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008323 Condensation domain; Region: Condensation; pfam00668 682795008324 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 682795008325 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795008326 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795008327 acyl-activating enzyme (AAE) consensus motif; other site 682795008328 AMP binding site [chemical binding]; other site 682795008329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008330 Condensation domain; Region: Condensation; pfam00668 682795008331 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 682795008332 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 682795008333 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 682795008334 acyl-activating enzyme (AAE) consensus motif; other site 682795008335 AMP binding site [chemical binding]; other site 682795008336 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008337 acyl-CoA synthetase; Validated; Region: PRK05850 682795008338 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 682795008339 acyl-activating enzyme (AAE) consensus motif; other site 682795008340 active site 682795008341 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795008342 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 682795008343 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 682795008344 active site 682795008345 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 682795008346 KR domain; Region: KR; pfam08659 682795008347 putative NADP binding site [chemical binding]; other site 682795008348 active site 682795008349 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 682795008350 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 682795008351 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 682795008352 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 682795008353 tetramerization interface [polypeptide binding]; other site 682795008354 active site 682795008355 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 682795008356 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 682795008357 Walker A/P-loop; other site 682795008358 ATP binding site [chemical binding]; other site 682795008359 Q-loop/lid; other site 682795008360 ABC transporter signature motif; other site 682795008361 Walker B; other site 682795008362 D-loop; other site 682795008363 H-loop/switch region; other site 682795008364 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 682795008365 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 682795008366 Thioesterase domain; Region: Thioesterase; pfam00975 682795008367 Ferritin-like domain; Region: Ferritin_2; pfam13668 682795008368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795008369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795008370 LysR substrate binding domain; Region: LysR_substrate; pfam03466 682795008371 dimerization interface [polypeptide binding]; other site 682795008372 Helix-turn-helix domain; Region: HTH_17; pfam12728 682795008373 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 682795008374 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 682795008375 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 682795008376 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 682795008377 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795008378 active site 682795008379 DNA binding site [nucleotide binding] 682795008380 Int/Topo IB signature motif; other site 682795008381 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 682795008382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 682795008383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795008384 ATP binding site [chemical binding]; other site 682795008385 Mg2+ binding site [ion binding]; other site 682795008386 G-X-G motif; other site 682795008387 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 682795008388 Active Sites [active] 682795008389 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 682795008390 DNA-sulfur modification-associated; Region: DndB; pfam14072 682795008391 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 682795008392 GIY-YIG motif/motif A; other site 682795008393 active site 682795008394 catalytic site [active] 682795008395 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 682795008396 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795008397 putative active site [active] 682795008398 putative metal binding site [ion binding]; other site 682795008399 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795008400 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795008401 active site 682795008402 DNA binding site [nucleotide binding] 682795008403 Int/Topo IB signature motif; other site 682795008404 Helix-turn-helix domain; Region: HTH_17; pfam12728 682795008405 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 682795008406 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 682795008407 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 682795008408 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 682795008409 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 682795008410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795008411 Coenzyme A binding pocket [chemical binding]; other site 682795008412 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 682795008413 Glycoprotease family; Region: Peptidase_M22; pfam00814 682795008414 Protein of unknown function, DUF488; Region: DUF488; pfam04343 682795008415 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 682795008416 Found in ATP-dependent protease La (LON); Region: LON; smart00464 682795008417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795008418 Walker A motif; other site 682795008419 ATP binding site [chemical binding]; other site 682795008420 Walker B motif; other site 682795008421 arginine finger; other site 682795008422 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 682795008423 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 682795008424 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 682795008425 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008426 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795008427 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795008428 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 682795008429 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 682795008430 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 682795008431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795008432 Coenzyme A binding pocket [chemical binding]; other site 682795008433 VanW like protein; Region: VanW; pfam04294 682795008434 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 682795008435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 682795008436 FeS/SAM binding site; other site 682795008437 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 682795008438 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 682795008439 ligand binding site [chemical binding]; other site 682795008440 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 682795008441 ligand binding site [chemical binding]; other site 682795008442 NADH dehydrogenase subunit B; Validated; Region: PRK06411 682795008443 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 682795008444 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 682795008445 metal binding triad; other site 682795008446 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 682795008447 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 682795008448 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 682795008449 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 682795008450 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 682795008451 Nitrogen regulatory protein P-II; Region: P-II; smart00938 682795008452 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 682795008453 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 682795008454 NeuB family; Region: NeuB; pfam03102 682795008455 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 682795008456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795008457 active site 682795008458 motif I; other site 682795008459 motif II; other site 682795008460 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 682795008461 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 682795008462 PYR/PP interface [polypeptide binding]; other site 682795008463 dimer interface [polypeptide binding]; other site 682795008464 TPP binding site [chemical binding]; other site 682795008465 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 682795008466 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 682795008467 TPP-binding site [chemical binding]; other site 682795008468 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 682795008469 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 682795008470 Metal-binding active site; metal-binding site 682795008471 D-mannonate oxidoreductase; Provisional; Region: PRK08277 682795008472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795008473 NAD(P) binding site [chemical binding]; other site 682795008474 active site 682795008475 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 682795008476 classical (c) SDRs; Region: SDR_c; cd05233 682795008477 NAD(P) binding site [chemical binding]; other site 682795008478 active site 682795008479 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 682795008480 short chain dehydrogenase; Provisional; Region: PRK06914 682795008481 NADP binding site [chemical binding]; other site 682795008482 active site 682795008483 steroid binding site; other site 682795008484 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 682795008485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795008486 NAD(P) binding site [chemical binding]; other site 682795008487 active site 682795008488 Predicted membrane protein [Function unknown]; Region: COG2246 682795008489 GtrA-like protein; Region: GtrA; pfam04138 682795008490 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 682795008491 Ligand binding site; other site 682795008492 Putative Catalytic site; other site 682795008493 DXD motif; other site 682795008494 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 682795008495 dimer interface [polypeptide binding]; other site 682795008496 active site 682795008497 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795008498 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 682795008499 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 682795008500 H+ Antiporter protein; Region: 2A0121; TIGR00900 682795008501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795008502 putative substrate translocation pore; other site 682795008503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795008504 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 682795008505 NAD(P) binding site [chemical binding]; other site 682795008506 active site 682795008507 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 682795008508 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 682795008509 inhibitor-cofactor binding pocket; inhibition site 682795008510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795008511 catalytic residue [active] 682795008512 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 682795008513 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 682795008514 substrate binding site; other site 682795008515 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 682795008516 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 682795008517 NAD binding site [chemical binding]; other site 682795008518 homotetramer interface [polypeptide binding]; other site 682795008519 homodimer interface [polypeptide binding]; other site 682795008520 substrate binding site [chemical binding]; other site 682795008521 active site 682795008522 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 682795008523 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 682795008524 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 682795008525 active site 682795008526 catalytic site [active] 682795008527 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 682795008528 G1 box; other site 682795008529 GTP/Mg2+ binding site [chemical binding]; other site 682795008530 Switch I region; other site 682795008531 G2 box; other site 682795008532 G3 box; other site 682795008533 Switch II region; other site 682795008534 G4 box; other site 682795008535 G5 box; other site 682795008536 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 682795008537 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 682795008538 Flavoprotein; Region: Flavoprotein; pfam02441 682795008539 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 682795008540 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795008541 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 682795008542 dimer interface [polypeptide binding]; other site 682795008543 FMN binding site [chemical binding]; other site 682795008544 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 682795008545 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 682795008546 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 682795008547 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 682795008548 CAAX protease self-immunity; Region: Abi; pfam02517 682795008549 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795008550 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 682795008551 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 682795008552 active site residue [active] 682795008553 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 682795008554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795008555 NAD(P) binding site [chemical binding]; other site 682795008556 active site 682795008557 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 682795008558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795008559 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795008560 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 682795008561 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 682795008562 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 682795008563 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 682795008564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795008565 active site 682795008566 motif I; other site 682795008567 motif II; other site 682795008568 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 682795008569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795008570 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795008571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795008572 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795008573 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 682795008574 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 682795008575 active site 682795008576 DinB family; Region: DinB; cl17821 682795008577 DinB superfamily; Region: DinB_2; pfam12867 682795008578 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 682795008579 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 682795008580 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 682795008581 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 682795008582 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 682795008583 potential catalytic triad [active] 682795008584 conserved cys residue [active] 682795008585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795008586 NAD(P) binding site [chemical binding]; other site 682795008587 active site 682795008588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795008589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795008590 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 682795008591 putative effector binding pocket; other site 682795008592 dimerization interface [polypeptide binding]; other site 682795008593 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 682795008594 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 682795008595 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008596 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795008597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795008598 putative substrate translocation pore; other site 682795008599 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 682795008600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795008601 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 682795008602 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 682795008603 active site 682795008604 HIGH motif; other site 682795008605 KMSKS motif; other site 682795008606 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 682795008607 tRNA binding surface [nucleotide binding]; other site 682795008608 anticodon binding site; other site 682795008609 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 682795008610 dimer interface [polypeptide binding]; other site 682795008611 putative tRNA-binding site [nucleotide binding]; other site 682795008612 Cupin domain; Region: Cupin_2; pfam07883 682795008613 Cupin domain; Region: Cupin_2; pfam07883 682795008614 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 682795008615 active site 682795008616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 682795008617 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 682795008618 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 682795008619 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 682795008620 substrate binding pocket [chemical binding]; other site 682795008621 chain length determination region; other site 682795008622 substrate-Mg2+ binding site; other site 682795008623 catalytic residues [active] 682795008624 aspartate-rich region 1; other site 682795008625 active site lid residues [active] 682795008626 aspartate-rich region 2; other site 682795008627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 682795008628 AAA domain; Region: AAA_33; pfam13671 682795008629 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 682795008630 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 682795008631 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 682795008632 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 682795008633 FAD binding site [chemical binding]; other site 682795008634 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 682795008635 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 682795008636 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 682795008637 trimer interface [polypeptide binding]; other site 682795008638 active site 682795008639 UDP-GlcNAc binding site [chemical binding]; other site 682795008640 lipid binding site [chemical binding]; lipid-binding site 682795008641 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 682795008642 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 682795008643 putative acyl-acceptor binding pocket; other site 682795008644 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 682795008645 putative amphipathic alpha helix; other site 682795008646 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 682795008647 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 682795008648 Chlorite dismutase; Region: Chlor_dismutase; cl01280 682795008649 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 682795008650 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 682795008651 minor groove reading motif; other site 682795008652 helix-hairpin-helix signature motif; other site 682795008653 substrate binding pocket [chemical binding]; other site 682795008654 active site 682795008655 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 682795008656 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 682795008657 active site 682795008658 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 682795008659 active site 682795008660 catalytic site [active] 682795008661 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 682795008662 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 682795008663 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 682795008664 intersubunit interface [polypeptide binding]; other site 682795008665 active site 682795008666 catalytic residue [active] 682795008667 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 682795008668 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 682795008669 NAD(P) binding site [chemical binding]; other site 682795008670 catalytic residues [active] 682795008671 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 682795008672 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 682795008673 short chain dehydrogenase; Provisional; Region: PRK06197 682795008674 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 682795008675 putative NAD(P) binding site [chemical binding]; other site 682795008676 active site 682795008677 Predicted transcriptional regulators [Transcription]; Region: COG1733 682795008678 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 682795008679 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 682795008680 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795008681 nucleotide binding site [chemical binding]; other site 682795008682 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 682795008683 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 682795008684 dimer interface [polypeptide binding]; other site 682795008685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795008686 catalytic residue [active] 682795008687 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 682795008688 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 682795008689 tetramer interface [polypeptide binding]; other site 682795008690 heme binding pocket [chemical binding]; other site 682795008691 NADPH binding site [chemical binding]; other site 682795008692 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 682795008693 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 682795008694 domain interfaces; other site 682795008695 active site 682795008696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795008697 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 682795008698 NAD(P) binding site [chemical binding]; other site 682795008699 active site 682795008700 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 682795008701 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 682795008702 tRNA; other site 682795008703 putative tRNA binding site [nucleotide binding]; other site 682795008704 putative NADP binding site [chemical binding]; other site 682795008705 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 682795008706 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 682795008707 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 682795008708 MutS domain I; Region: MutS_I; pfam01624 682795008709 MutS domain II; Region: MutS_II; pfam05188 682795008710 MutS domain III; Region: MutS_III; pfam05192 682795008711 MutS domain V; Region: MutS_V; pfam00488 682795008712 Walker A/P-loop; other site 682795008713 ATP binding site [chemical binding]; other site 682795008714 Q-loop/lid; other site 682795008715 ABC transporter signature motif; other site 682795008716 Walker B; other site 682795008717 D-loop; other site 682795008718 H-loop/switch region; other site 682795008719 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 682795008720 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 682795008721 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 682795008722 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 682795008723 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 682795008724 active site 682795008725 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 682795008726 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795008727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795008728 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 682795008729 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008730 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008731 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795008732 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 682795008733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795008734 alpha-galactosidase; Region: PLN02808; cl17638 682795008735 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 682795008736 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 682795008737 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 682795008738 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795008739 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795008740 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795008741 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795008742 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795008743 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008744 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 682795008745 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 682795008746 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 682795008747 ligand binding site [chemical binding]; other site 682795008748 mannonate dehydratase; Region: uxuA; TIGR00695 682795008749 mannonate dehydratase; Provisional; Region: PRK03906 682795008750 aldose dehydrogenase; Validated; Region: PRK06398 682795008751 classical (c) SDRs; Region: SDR_c; cd05233 682795008752 NAD(P) binding site [chemical binding]; other site 682795008753 active site 682795008754 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 682795008755 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008756 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795008757 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 682795008758 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 682795008759 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 682795008760 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 682795008761 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 682795008762 Multicopper oxidase; Region: Cu-oxidase; pfam00394 682795008763 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 682795008764 HEAT repeats; Region: HEAT_2; pfam13646 682795008765 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 682795008766 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795008767 active site 682795008768 metal binding site [ion binding]; metal-binding site 682795008769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795008770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795008771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 682795008772 dimerization interface [polypeptide binding]; other site 682795008773 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 682795008774 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 682795008775 dimer interface [polypeptide binding]; other site 682795008776 active site 682795008777 heme binding site [chemical binding]; other site 682795008778 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 682795008779 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 682795008780 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 682795008781 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 682795008782 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 682795008783 Membrane transport protein; Region: Mem_trans; cl09117 682795008784 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 682795008785 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 682795008786 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 682795008787 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 682795008788 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 682795008789 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 682795008790 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795008791 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 682795008792 dimerization interface [polypeptide binding]; other site 682795008793 substrate binding pocket [chemical binding]; other site 682795008794 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 682795008795 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 682795008796 homodimer interface [polypeptide binding]; other site 682795008797 active site 682795008798 TDP-binding site; other site 682795008799 acceptor substrate-binding pocket; other site 682795008800 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 682795008801 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 682795008802 NADP binding site [chemical binding]; other site 682795008803 substrate binding site [chemical binding]; other site 682795008804 active site 682795008805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795008806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795008807 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795008808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795008809 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 682795008810 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008811 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 682795008812 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 682795008813 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 682795008814 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 682795008815 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795008816 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795008817 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 682795008818 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795008819 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 682795008820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795008821 catalytic residue [active] 682795008822 putative oxidoreductase; Provisional; Region: PRK11579 682795008823 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795008824 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 682795008825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795008826 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 682795008827 putative substrate translocation pore; other site 682795008828 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 682795008829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 682795008830 Histidine kinase; Region: HisKA_3; pfam07730 682795008831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795008832 ATP binding site [chemical binding]; other site 682795008833 Mg2+ binding site [ion binding]; other site 682795008834 G-X-G motif; other site 682795008835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 682795008836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795008837 active site 682795008838 phosphorylation site [posttranslational modification] 682795008839 intermolecular recognition site; other site 682795008840 dimerization interface [polypeptide binding]; other site 682795008841 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795008842 DNA binding residues [nucleotide binding] 682795008843 dimerization interface [polypeptide binding]; other site 682795008844 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 682795008845 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 682795008846 dihydroorotase; Provisional; Region: PRK09237 682795008847 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795008848 active site 682795008849 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 682795008850 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 682795008851 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 682795008852 Walker A/P-loop; other site 682795008853 ATP binding site [chemical binding]; other site 682795008854 Q-loop/lid; other site 682795008855 ABC transporter signature motif; other site 682795008856 Walker B; other site 682795008857 D-loop; other site 682795008858 H-loop/switch region; other site 682795008859 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795008860 FtsX-like permease family; Region: FtsX; pfam02687 682795008861 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 682795008862 homotrimer interaction site [polypeptide binding]; other site 682795008863 putative active site [active] 682795008864 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008865 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795008866 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 682795008867 FAD binding domain; Region: FAD_binding_4; pfam01565 682795008868 Berberine and berberine like; Region: BBE; pfam08031 682795008869 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 682795008870 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 682795008871 Permease; Region: Permease; pfam02405 682795008872 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 682795008873 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 682795008874 Walker A/P-loop; other site 682795008875 ATP binding site [chemical binding]; other site 682795008876 Q-loop/lid; other site 682795008877 ABC transporter signature motif; other site 682795008878 Walker B; other site 682795008879 D-loop; other site 682795008880 H-loop/switch region; other site 682795008881 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 682795008882 mce related protein; Region: MCE; pfam02470 682795008883 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 682795008884 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 682795008885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 682795008886 classical (c) SDRs; Region: SDR_c; cd05233 682795008887 NAD(P) binding site [chemical binding]; other site 682795008888 active site 682795008889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795008890 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795008891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795008892 Cupin domain; Region: Cupin_2; cl17218 682795008893 Cupin domain; Region: Cupin_2; cl17218 682795008894 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 682795008895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795008896 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795008897 active site 682795008898 catalytic tetrad [active] 682795008899 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795008900 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795008901 active site 682795008902 catalytic tetrad [active] 682795008903 Cupin domain; Region: Cupin_2; cl17218 682795008904 NIPSNAP; Region: NIPSNAP; pfam07978 682795008905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795008906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795008907 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 682795008908 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 682795008909 Predicted flavoprotein [General function prediction only]; Region: COG0431 682795008910 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 682795008911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795008912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795008913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 682795008914 dimerization interface [polypeptide binding]; other site 682795008915 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 682795008916 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 682795008917 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 682795008918 Metal-binding active site; metal-binding site 682795008919 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795008920 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795008921 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795008922 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795008923 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795008924 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795008925 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795008926 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795008927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795008928 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795008929 active site 682795008930 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795008931 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795008932 active site 682795008933 metal binding site [ion binding]; metal-binding site 682795008934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795008935 D-galactonate transporter; Region: 2A0114; TIGR00893 682795008936 putative substrate translocation pore; other site 682795008937 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 682795008938 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 682795008939 NADP binding site [chemical binding]; other site 682795008940 homodimer interface [polypeptide binding]; other site 682795008941 active site 682795008942 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 682795008943 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 682795008944 putative NAD(P) binding site [chemical binding]; other site 682795008945 catalytic Zn binding site [ion binding]; other site 682795008946 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795008947 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 682795008948 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 682795008949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795008950 active site 682795008951 phosphorylation site [posttranslational modification] 682795008952 intermolecular recognition site; other site 682795008953 dimerization interface [polypeptide binding]; other site 682795008954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795008955 DNA binding residues [nucleotide binding] 682795008956 dimerization interface [polypeptide binding]; other site 682795008957 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 682795008958 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 682795008959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 682795008960 Histidine kinase; Region: HisKA_3; pfam07730 682795008961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795008962 ATP binding site [chemical binding]; other site 682795008963 Mg2+ binding site [ion binding]; other site 682795008964 G-X-G motif; other site 682795008965 Ricin-type beta-trefoil; Region: RICIN; smart00458 682795008966 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 682795008967 putative sugar binding sites [chemical binding]; other site 682795008968 Q-X-W motif; other site 682795008969 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 682795008970 Putative Ig domain; Region: He_PIG; pfam05345 682795008971 hypothetical protein; Provisional; Region: PRK06489 682795008972 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 682795008973 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 682795008974 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 682795008975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795008976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795008977 DNA binding site [nucleotide binding] 682795008978 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 682795008979 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 682795008980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795008981 Walker A motif; other site 682795008982 ATP binding site [chemical binding]; other site 682795008983 Walker B motif; other site 682795008984 arginine finger; other site 682795008985 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 682795008986 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 682795008987 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 682795008988 Ligand Binding Site [chemical binding]; other site 682795008989 Bacterial sugar transferase; Region: Bac_transf; pfam02397 682795008990 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 682795008991 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 682795008992 inhibitor-cofactor binding pocket; inhibition site 682795008993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795008994 catalytic residue [active] 682795008995 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 682795008996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795008997 NAD(P) binding site [chemical binding]; other site 682795008998 active site 682795008999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795009000 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795009001 NAD(P) binding site [chemical binding]; other site 682795009002 active site 682795009003 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 682795009004 active site 682795009005 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 682795009006 homodimer interface [polypeptide binding]; other site 682795009007 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 682795009008 putative trimer interface [polypeptide binding]; other site 682795009009 putative CoA binding site [chemical binding]; other site 682795009010 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 682795009011 putative trimer interface [polypeptide binding]; other site 682795009012 putative active site [active] 682795009013 putative substrate binding site [chemical binding]; other site 682795009014 putative CoA binding site [chemical binding]; other site 682795009015 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 682795009016 Putative Catalytic site; other site 682795009017 DXD motif; other site 682795009018 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 682795009019 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 682795009020 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 682795009021 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 682795009022 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795009023 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795009024 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 682795009025 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 682795009026 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 682795009027 hypothetical protein; Provisional; Region: PRK07233 682795009028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 682795009029 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 682795009030 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 682795009031 putative active site [active] 682795009032 putative metal binding site [ion binding]; other site 682795009033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795009034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795009035 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795009036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795009037 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 682795009038 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 682795009039 SLBB domain; Region: SLBB; pfam10531 682795009040 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 682795009041 Chain length determinant protein; Region: Wzz; cl15801 682795009042 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 682795009043 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 682795009044 Predicted membrane protein [Function unknown]; Region: COG3463 682795009045 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 682795009046 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 682795009047 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 682795009048 O-Antigen ligase; Region: Wzy_C; cl04850 682795009049 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 682795009050 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795009051 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 682795009052 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 682795009053 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 682795009054 DXD motif; other site 682795009055 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 682795009056 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 682795009057 putative active site [active] 682795009058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 682795009059 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795009060 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 682795009061 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 682795009062 active site 682795009063 substrate binding site [chemical binding]; other site 682795009064 trimer interface [polypeptide binding]; other site 682795009065 CoA binding site [chemical binding]; other site 682795009066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795009067 PAS domain; Region: PAS_9; pfam13426 682795009068 putative active site [active] 682795009069 heme pocket [chemical binding]; other site 682795009070 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795009071 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 682795009072 ligand binding site [chemical binding]; other site 682795009073 flexible hinge region; other site 682795009074 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 682795009075 non-specific DNA interactions [nucleotide binding]; other site 682795009076 DNA binding site [nucleotide binding] 682795009077 sequence specific DNA binding site [nucleotide binding]; other site 682795009078 putative cAMP binding site [chemical binding]; other site 682795009079 Tannase and feruloyl esterase; Region: Tannase; pfam07519 682795009080 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 682795009081 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 682795009082 Ca binding site [ion binding]; other site 682795009083 active site 682795009084 catalytic site [active] 682795009085 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 682795009086 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009087 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795009088 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795009089 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 682795009090 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795009091 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 682795009092 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795009093 TIGR03118 family protein; Region: PEPCTERM_chp_1 682795009094 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222 682795009095 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 682795009096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 682795009097 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 682795009098 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 682795009099 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 682795009100 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 682795009101 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 682795009102 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 682795009103 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 682795009104 catalytic loop [active] 682795009105 iron binding site [ion binding]; other site 682795009106 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 682795009107 Penicillin amidase; Region: Penicil_amidase; pfam01804 682795009108 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 682795009109 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 682795009110 active site 682795009111 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 682795009112 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 682795009113 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795009114 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 682795009115 active site 682795009116 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795009117 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795009118 Amidohydrolase; Region: Amidohydro_4; pfam13147 682795009119 active site 682795009120 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 682795009121 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 682795009122 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 682795009123 putative sugar binding sites [chemical binding]; other site 682795009124 Q-X-W motif; other site 682795009125 alpha-galactosidase; Region: PLN02808; cl17638 682795009126 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795009127 Ca binding site [ion binding]; other site 682795009128 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 682795009129 Ca binding site [ion binding]; other site 682795009130 Domain of unknown function (DUF336); Region: DUF336; cl01249 682795009131 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 682795009132 Uncharacterized conserved protein [Function unknown]; Region: COG3391 682795009133 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 682795009134 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795009135 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 682795009136 active site 682795009137 metal binding site [ion binding]; metal-binding site 682795009138 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009139 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795009140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795009141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795009142 active site 682795009143 phosphorylation site [posttranslational modification] 682795009144 intermolecular recognition site; other site 682795009145 dimerization interface [polypeptide binding]; other site 682795009146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795009147 DNA binding site [nucleotide binding] 682795009148 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 682795009149 HAMP domain; Region: HAMP; pfam00672 682795009150 dimerization interface [polypeptide binding]; other site 682795009151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795009152 dimer interface [polypeptide binding]; other site 682795009153 phosphorylation site [posttranslational modification] 682795009154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795009155 ATP binding site [chemical binding]; other site 682795009156 Mg2+ binding site [ion binding]; other site 682795009157 G-X-G motif; other site 682795009158 PQQ-like domain; Region: PQQ_2; pfam13360 682795009159 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 682795009160 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 682795009161 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795009162 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 682795009163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 682795009164 dimerization interface [polypeptide binding]; other site 682795009165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795009166 dimer interface [polypeptide binding]; other site 682795009167 phosphorylation site [posttranslational modification] 682795009168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795009169 ATP binding site [chemical binding]; other site 682795009170 Mg2+ binding site [ion binding]; other site 682795009171 G-X-G motif; other site 682795009172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795009173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795009174 active site 682795009175 phosphorylation site [posttranslational modification] 682795009176 intermolecular recognition site; other site 682795009177 dimerization interface [polypeptide binding]; other site 682795009178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795009179 DNA binding site [nucleotide binding] 682795009180 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009181 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795009182 Uncharacterized conserved protein [Function unknown]; Region: COG3391 682795009183 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 682795009184 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 682795009185 active site 682795009186 putative alpha-glucosidase; Provisional; Region: PRK10658 682795009187 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 682795009188 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 682795009189 active site 682795009190 catalytic site [active] 682795009191 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 682795009192 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009193 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 682795009194 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 682795009195 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 682795009196 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795009197 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795009198 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 682795009199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795009200 putative substrate translocation pore; other site 682795009201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795009202 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 682795009203 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795009204 FtsX-like permease family; Region: FtsX; pfam02687 682795009205 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 682795009206 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 682795009207 Walker A/P-loop; other site 682795009208 ATP binding site [chemical binding]; other site 682795009209 Q-loop/lid; other site 682795009210 ABC transporter signature motif; other site 682795009211 Walker B; other site 682795009212 D-loop; other site 682795009213 H-loop/switch region; other site 682795009214 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 682795009215 active site 682795009216 catalytic triad [active] 682795009217 oxyanion hole [active] 682795009218 switch loop; other site 682795009219 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 682795009220 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 682795009221 RNA binding site [nucleotide binding]; other site 682795009222 active site 682795009223 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 682795009224 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 682795009225 homodecamer interface [polypeptide binding]; other site 682795009226 GTP cyclohydrolase I; Provisional; Region: PLN03044 682795009227 active site 682795009228 putative catalytic site residues [active] 682795009229 zinc binding site [ion binding]; other site 682795009230 GTP-CH-I/GFRP interaction surface; other site 682795009231 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 682795009232 active site 682795009233 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 682795009234 active site 682795009235 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 682795009236 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 682795009237 active site 682795009238 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 682795009239 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795009240 catalytic residues [active] 682795009241 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 682795009242 Iron permease FTR1 family; Region: FTR1; cl00475 682795009243 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 682795009244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795009245 FtsX-like permease family; Region: FtsX; pfam02687 682795009246 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795009247 FtsX-like permease family; Region: FtsX; pfam02687 682795009248 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 682795009249 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 682795009250 Walker A/P-loop; other site 682795009251 ATP binding site [chemical binding]; other site 682795009252 Q-loop/lid; other site 682795009253 ABC transporter signature motif; other site 682795009254 Walker B; other site 682795009255 D-loop; other site 682795009256 H-loop/switch region; other site 682795009257 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 682795009258 ATP-NAD kinase; Region: NAD_kinase; pfam01513 682795009259 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 682795009260 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 682795009261 RNA binding surface [nucleotide binding]; other site 682795009262 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 682795009263 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 682795009264 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 682795009265 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 682795009266 DsbD alpha interface [polypeptide binding]; other site 682795009267 catalytic residues [active] 682795009268 Aspartyl protease; Region: Asp_protease_2; pfam13650 682795009269 inhibitor binding site; inhibition site 682795009270 catalytic motif [active] 682795009271 Catalytic residue [active] 682795009272 Active site flap [active] 682795009273 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 682795009274 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 682795009275 inhibitor binding site; inhibition site 682795009276 catalytic motif [active] 682795009277 Catalytic residue [active] 682795009278 Active site flap [active] 682795009279 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 682795009280 ATP-grasp domain; Region: ATP-grasp; pfam02222 682795009281 AIR carboxylase; Region: AIRC; pfam00731 682795009282 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 682795009283 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 682795009284 active site 682795009285 substrate binding site [chemical binding]; other site 682795009286 cosubstrate binding site; other site 682795009287 catalytic site [active] 682795009288 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 682795009289 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 682795009290 ATP-grasp domain; Region: ATP-grasp_4; cl17255 682795009291 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 682795009292 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 682795009293 active site 682795009294 ATP binding site [chemical binding]; other site 682795009295 substrate binding site [chemical binding]; other site 682795009296 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 682795009297 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 682795009298 dimerization interface [polypeptide binding]; other site 682795009299 putative ATP binding site [chemical binding]; other site 682795009300 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 682795009301 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 682795009302 dimerization interface [polypeptide binding]; other site 682795009303 ATP binding site [chemical binding]; other site 682795009304 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 682795009305 dimerization interface [polypeptide binding]; other site 682795009306 ATP binding site [chemical binding]; other site 682795009307 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 682795009308 putative active site [active] 682795009309 catalytic triad [active] 682795009310 amidophosphoribosyltransferase; Provisional; Region: PRK09246 682795009311 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 682795009312 active site 682795009313 tetramer interface [polypeptide binding]; other site 682795009314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 682795009315 active site 682795009316 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 682795009317 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 682795009318 NAD synthetase; Provisional; Region: PRK13981 682795009319 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 682795009320 multimer interface [polypeptide binding]; other site 682795009321 active site 682795009322 catalytic triad [active] 682795009323 protein interface 1 [polypeptide binding]; other site 682795009324 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 682795009325 homodimer interface [polypeptide binding]; other site 682795009326 NAD binding pocket [chemical binding]; other site 682795009327 ATP binding pocket [chemical binding]; other site 682795009328 Mg binding site [ion binding]; other site 682795009329 active-site loop [active] 682795009330 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 682795009331 Bacterial sugar transferase; Region: Bac_transf; pfam02397 682795009332 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 682795009333 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 682795009334 Walker A/P-loop; other site 682795009335 ATP binding site [chemical binding]; other site 682795009336 Q-loop/lid; other site 682795009337 ABC transporter signature motif; other site 682795009338 Walker B; other site 682795009339 D-loop; other site 682795009340 H-loop/switch region; other site 682795009341 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 682795009342 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 682795009343 GTP binding site; other site 682795009344 hypothetical protein; Provisional; Region: PRK08201 682795009345 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 682795009346 metal binding site [ion binding]; metal-binding site 682795009347 putative dimer interface [polypeptide binding]; other site 682795009348 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 682795009349 active site 682795009350 catalytic triad [active] 682795009351 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 682795009352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 682795009353 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 682795009354 SEC-C motif; Region: SEC-C; pfam02810 682795009355 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 682795009356 putative hydrophobic ligand binding site [chemical binding]; other site 682795009357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795009358 dimerization interface [polypeptide binding]; other site 682795009359 putative DNA binding site [nucleotide binding]; other site 682795009360 putative Zn2+ binding site [ion binding]; other site 682795009361 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 682795009362 active site residue [active] 682795009363 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 682795009364 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 682795009365 active site 682795009366 intersubunit interface [polypeptide binding]; other site 682795009367 catalytic residue [active] 682795009368 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 682795009369 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 682795009370 substrate binding site [chemical binding]; other site 682795009371 ATP binding site [chemical binding]; other site 682795009372 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 682795009373 Cupin domain; Region: Cupin_2; pfam07883 682795009374 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 682795009375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795009376 NAD(P) binding site [chemical binding]; other site 682795009377 active site 682795009378 Helix-turn-helix domain; Region: HTH_28; pfam13518 682795009379 Winged helix-turn helix; Region: HTH_29; pfam13551 682795009380 Homeodomain-like domain; Region: HTH_32; pfam13565 682795009381 putative transposase OrfB; Reviewed; Region: PHA02517 682795009382 Integrase core domain; Region: rve; pfam00665 682795009383 Integrase core domain; Region: rve_3; pfam13683 682795009384 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 682795009385 rod shape-determining protein MreB; Provisional; Region: PRK13927 682795009386 MreB and similar proteins; Region: MreB_like; cd10225 682795009387 nucleotide binding site [chemical binding]; other site 682795009388 Mg binding site [ion binding]; other site 682795009389 putative protofilament interaction site [polypeptide binding]; other site 682795009390 RodZ interaction site [polypeptide binding]; other site 682795009391 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 682795009392 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 682795009393 hexamer interface [polypeptide binding]; other site 682795009394 ligand binding site [chemical binding]; other site 682795009395 putative active site [active] 682795009396 NAD(P) binding site [chemical binding]; other site 682795009397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 682795009398 dimerization interface [polypeptide binding]; other site 682795009399 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 682795009400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795009401 putative active site [active] 682795009402 heme pocket [chemical binding]; other site 682795009403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795009404 dimer interface [polypeptide binding]; other site 682795009405 phosphorylation site [posttranslational modification] 682795009406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795009407 ATP binding site [chemical binding]; other site 682795009408 Mg2+ binding site [ion binding]; other site 682795009409 G-X-G motif; other site 682795009410 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 682795009411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795009412 active site 682795009413 phosphorylation site [posttranslational modification] 682795009414 intermolecular recognition site; other site 682795009415 dimerization interface [polypeptide binding]; other site 682795009416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795009417 Walker A motif; other site 682795009418 ATP binding site [chemical binding]; other site 682795009419 Walker B motif; other site 682795009420 arginine finger; other site 682795009421 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 682795009422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795009423 TIGR01777 family protein; Region: yfcH 682795009424 NAD(P) binding site [chemical binding]; other site 682795009425 active site 682795009426 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 682795009427 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 682795009428 GTPase Era; Reviewed; Region: era; PRK00089 682795009429 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 682795009430 G1 box; other site 682795009431 GTP/Mg2+ binding site [chemical binding]; other site 682795009432 Switch I region; other site 682795009433 G2 box; other site 682795009434 Switch II region; other site 682795009435 G3 box; other site 682795009436 G4 box; other site 682795009437 G5 box; other site 682795009438 KH domain; Region: KH_2; pfam07650 682795009439 FOG: CBS domain [General function prediction only]; Region: COG0517 682795009440 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 682795009441 Transporter associated domain; Region: CorC_HlyC; smart01091 682795009442 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 682795009443 PhoH-like protein; Region: PhoH; pfam02562 682795009444 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 682795009445 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 682795009446 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 682795009447 active site 682795009448 Zn binding site [ion binding]; other site 682795009449 EamA-like transporter family; Region: EamA; pfam00892 682795009450 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 682795009451 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 682795009452 threonine synthase; Validated; Region: PRK08197 682795009453 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 682795009454 homodimer interface [polypeptide binding]; other site 682795009455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795009456 catalytic residue [active] 682795009457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795009458 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 682795009459 active site 682795009460 motif I; other site 682795009461 motif II; other site 682795009462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795009463 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 682795009464 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 682795009465 N-acetyl-D-glucosamine binding site [chemical binding]; other site 682795009466 catalytic residue [active] 682795009467 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 682795009468 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 682795009469 ATP cone domain; Region: ATP-cone; pfam03477 682795009470 tartrate dehydrogenase; Region: TTC; TIGR02089 682795009471 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 682795009472 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009473 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 682795009474 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 682795009475 aspartate kinase III; Validated; Region: PRK09084 682795009476 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 682795009477 putative catalytic residues [active] 682795009478 nucleotide binding site [chemical binding]; other site 682795009479 aspartate binding site [chemical binding]; other site 682795009480 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 682795009481 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 682795009482 dihydrodipicolinate reductase; Provisional; Region: PRK00048 682795009483 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 682795009484 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 682795009485 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 682795009486 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 682795009487 PIN domain; Region: PIN; pfam01850 682795009488 putative active site [active] 682795009489 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 682795009490 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 682795009491 dihydrodipicolinate synthase; Region: dapA; TIGR00674 682795009492 dimer interface [polypeptide binding]; other site 682795009493 active site 682795009494 catalytic residue [active] 682795009495 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 682795009496 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 682795009497 active site pocket [active] 682795009498 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795009499 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 682795009500 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 682795009501 trimer interface [polypeptide binding]; other site 682795009502 active site 682795009503 substrate binding site [chemical binding]; other site 682795009504 CoA binding site [chemical binding]; other site 682795009505 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 682795009506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 682795009507 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 682795009508 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 682795009509 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009510 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 682795009511 OPT oligopeptide transporter protein; Region: OPT; cl14607 682795009512 OPT oligopeptide transporter protein; Region: OPT; cl14607 682795009513 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 682795009514 TPR repeat; Region: TPR_11; pfam13414 682795009515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795009516 binding surface 682795009517 TPR motif; other site 682795009518 TPR repeat; Region: TPR_11; pfam13414 682795009519 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 682795009520 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 682795009521 P-loop; other site 682795009522 Magnesium ion binding site [ion binding]; other site 682795009523 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 682795009524 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795009525 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 682795009526 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 682795009527 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795009528 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009529 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 682795009530 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 682795009531 Interdomain contacts; other site 682795009532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 682795009533 Histidine kinase; Region: HisKA_3; pfam07730 682795009534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795009535 ATP binding site [chemical binding]; other site 682795009536 Mg2+ binding site [ion binding]; other site 682795009537 G-X-G motif; other site 682795009538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 682795009539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795009540 active site 682795009541 phosphorylation site [posttranslational modification] 682795009542 intermolecular recognition site; other site 682795009543 dimerization interface [polypeptide binding]; other site 682795009544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795009545 DNA binding residues [nucleotide binding] 682795009546 dimerization interface [polypeptide binding]; other site 682795009547 HipA N-terminal domain; Region: Couple_hipA; pfam13657 682795009548 HipA-like N-terminal domain; Region: HipA_N; pfam07805 682795009549 HipA-like C-terminal domain; Region: HipA_C; pfam07804 682795009550 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 682795009551 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795009552 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795009553 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795009554 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795009555 Immunoglobulin domain; Region: Ig; cl11960 682795009556 Immunoglobulin domain; Region: Ig_2; pfam13895 682795009557 Immunoglobulin I-set domain; Region: I-set; pfam07679 682795009558 Immunoglobulin domain; Region: Ig; cd00096 682795009559 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795009560 sugar binding site [chemical binding]; other site 682795009561 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 682795009562 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795009563 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795009564 sugar binding site [chemical binding]; other site 682795009565 Immunoglobulin I-set domain; Region: I-set; pfam07679 682795009566 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795009567 sugar binding site [chemical binding]; other site 682795009568 Immunoglobulin domain; Region: Ig_2; pfam13895 682795009569 Immunoglobulin I-set domain; Region: I-set; pfam07679 682795009570 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 682795009571 substrate binding pocket [chemical binding]; other site 682795009572 catalytic residues [active] 682795009573 acyltransferase PapA5; Provisional; Region: PRK09294 682795009574 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 682795009575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 682795009576 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 682795009577 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 682795009578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795009579 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 682795009580 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 682795009581 DNA binding site [nucleotide binding] 682795009582 active site 682795009583 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 682795009584 endonuclease III; Region: ENDO3c; smart00478 682795009585 minor groove reading motif; other site 682795009586 helix-hairpin-helix signature motif; other site 682795009587 substrate binding pocket [chemical binding]; other site 682795009588 active site 682795009589 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 682795009590 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 682795009591 DNA binding site [nucleotide binding] 682795009592 active site 682795009593 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 682795009594 additional DNA contacts [nucleotide binding]; other site 682795009595 mismatch recognition site; other site 682795009596 active site 682795009597 zinc binding site [ion binding]; other site 682795009598 DNA intercalation site [nucleotide binding]; other site 682795009599 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795009600 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795009601 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795009602 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 682795009603 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795009604 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 682795009605 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 682795009606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795009607 Walker A/P-loop; other site 682795009608 ATP binding site [chemical binding]; other site 682795009609 Q-loop/lid; other site 682795009610 ABC transporter signature motif; other site 682795009611 Walker B; other site 682795009612 D-loop; other site 682795009613 H-loop/switch region; other site 682795009614 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 682795009615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795009616 NmrA-like family; Region: NmrA; pfam05368 682795009617 NAD(P) binding site [chemical binding]; other site 682795009618 active site 682795009619 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 682795009620 Cytochrome P450; Region: p450; cl12078 682795009621 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 682795009622 peptidase domain interface [polypeptide binding]; other site 682795009623 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 682795009624 active site 682795009625 catalytic triad [active] 682795009626 calcium binding site [ion binding]; other site 682795009627 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 682795009628 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 682795009629 ligand binding site [chemical binding]; other site 682795009630 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 682795009631 putative switch regulator; other site 682795009632 non-specific DNA interactions [nucleotide binding]; other site 682795009633 DNA binding site [nucleotide binding] 682795009634 sequence specific DNA binding site [nucleotide binding]; other site 682795009635 putative cAMP binding site [chemical binding]; other site 682795009636 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 682795009637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795009638 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 682795009639 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 682795009640 Histidine kinase; Region: HisKA_3; pfam07730 682795009641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795009642 ATP binding site [chemical binding]; other site 682795009643 Mg2+ binding site [ion binding]; other site 682795009644 G-X-G motif; other site 682795009645 benzoylformate decarboxylase; Reviewed; Region: PRK07092 682795009646 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 682795009647 PYR/PP interface [polypeptide binding]; other site 682795009648 dimer interface [polypeptide binding]; other site 682795009649 TPP binding site [chemical binding]; other site 682795009650 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 682795009651 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 682795009652 TPP-binding site [chemical binding]; other site 682795009653 dimer interface [polypeptide binding]; other site 682795009654 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 682795009655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795009656 putative DNA binding site [nucleotide binding]; other site 682795009657 putative Zn2+ binding site [ion binding]; other site 682795009658 AsnC family; Region: AsnC_trans_reg; pfam01037 682795009659 tyrosine decarboxylase; Region: PLN02880 682795009660 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 682795009661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795009662 catalytic residue [active] 682795009663 Chorismate mutase type II; Region: CM_2; cl00693 682795009664 Cupin domain; Region: Cupin_2; pfam07883 682795009665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795009666 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 682795009667 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 682795009668 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795009669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795009670 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795009671 DNA binding residues [nucleotide binding] 682795009672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 682795009673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795009674 active site 682795009675 phosphorylation site [posttranslational modification] 682795009676 intermolecular recognition site; other site 682795009677 dimerization interface [polypeptide binding]; other site 682795009678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795009679 DNA binding residues [nucleotide binding] 682795009680 dimerization interface [polypeptide binding]; other site 682795009681 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795009682 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 682795009683 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 682795009684 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 682795009685 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 682795009686 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 682795009687 active site 682795009688 catalytic triad [active] 682795009689 oxyanion hole [active] 682795009690 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 682795009691 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 682795009692 dimer interface [polypeptide binding]; other site 682795009693 decamer (pentamer of dimers) interface [polypeptide binding]; other site 682795009694 catalytic triad [active] 682795009695 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 682795009696 NADH(P)-binding; Region: NAD_binding_10; pfam13460 682795009697 NAD binding site [chemical binding]; other site 682795009698 substrate binding site [chemical binding]; other site 682795009699 putative active site [active] 682795009700 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 682795009701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 682795009702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795009703 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 682795009704 PQQ-like domain; Region: PQQ_2; pfam13360 682795009705 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 682795009706 Trp docking motif [polypeptide binding]; other site 682795009707 active site 682795009708 PQQ-like domain; Region: PQQ_2; pfam13360 682795009709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795009710 metabolite-proton symporter; Region: 2A0106; TIGR00883 682795009711 putative substrate translocation pore; other site 682795009712 choline dehydrogenase; Validated; Region: PRK02106 682795009713 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 682795009714 Protein of unknown function (DUF418); Region: DUF418; cl12135 682795009715 Protein of unknown function (DUF418); Region: DUF418; pfam04235 682795009716 ParB-like nuclease domain; Region: ParB; smart00470 682795009717 Winged helix-turn helix; Region: HTH_29; pfam13551 682795009718 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 682795009719 DNA-binding interface [nucleotide binding]; DNA binding site 682795009720 Homeodomain-like domain; Region: HTH_32; pfam13565 682795009721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 682795009722 Integrase core domain; Region: rve; pfam00665 682795009723 Integrase core domain; Region: rve_3; pfam13683 682795009724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795009725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795009726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 682795009727 dimerization interface [polypeptide binding]; other site 682795009728 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 682795009729 active site 682795009730 catalytic residues [active] 682795009731 DNA binding site [nucleotide binding] 682795009732 Int/Topo IB signature motif; other site 682795009733 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 682795009734 AMIN domain; Region: AMIN; pfam11741 682795009735 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 682795009736 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 682795009737 active site 682795009738 metal binding site [ion binding]; metal-binding site 682795009739 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 682795009740 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 682795009741 motif 1; other site 682795009742 active site 682795009743 motif 2; other site 682795009744 motif 3; other site 682795009745 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 682795009746 DHHA1 domain; Region: DHHA1; pfam02272 682795009747 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 682795009748 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 682795009749 putative active site [active] 682795009750 RecX family; Region: RecX; pfam02631 682795009751 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 682795009752 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795009753 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795009754 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795009755 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 682795009756 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 682795009757 active site 682795009758 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 682795009759 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 682795009760 active site 682795009761 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 682795009762 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 682795009763 FAD binding site [chemical binding]; other site 682795009764 homotetramer interface [polypeptide binding]; other site 682795009765 substrate binding pocket [chemical binding]; other site 682795009766 catalytic base [active] 682795009767 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 682795009768 UbiA prenyltransferase family; Region: UbiA; pfam01040 682795009769 Protein of unknown function (DUF420); Region: DUF420; pfam04238 682795009770 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 682795009771 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 682795009772 dimer interface [polypeptide binding]; other site 682795009773 ssDNA binding site [nucleotide binding]; other site 682795009774 tetramer (dimer of dimers) interface [polypeptide binding]; other site 682795009775 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 682795009776 active site 682795009777 catalytic triad [active] 682795009778 oxyanion hole [active] 682795009779 D-mannose binding lectin; Region: B_lectin; pfam01453 682795009780 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 682795009781 mannose binding site [chemical binding]; other site 682795009782 TIGR03790 family protein; Region: TIGR03790 682795009783 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 682795009784 ligand binding site [chemical binding]; other site 682795009785 metal binding site [ion binding]; metal-binding site 682795009786 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 682795009787 metal binding site [ion binding]; metal-binding site 682795009788 ligand binding site [chemical binding]; other site 682795009789 TIGR03790 family protein; Region: TIGR03790 682795009790 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 682795009791 metal binding site [ion binding]; metal-binding site 682795009792 ligand binding site [chemical binding]; other site 682795009793 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 682795009794 ligand binding site [chemical binding]; other site 682795009795 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009796 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795009797 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795009798 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795009799 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795009800 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 682795009801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 682795009802 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 682795009803 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 682795009804 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 682795009805 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 682795009806 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 682795009807 Ferritin-like domain; Region: Ferritin_2; pfam13668 682795009808 TIGR03118 family protein; Region: PEPCTERM_chp_1 682795009809 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 682795009810 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 682795009811 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 682795009812 CEO family (DUF1632); Region: DUF1632; pfam07857 682795009813 EamA-like transporter family; Region: EamA; pfam00892 682795009814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795009815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795009816 DNA binding site [nucleotide binding] 682795009817 domain linker motif; other site 682795009818 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795009819 dimerization interface [polypeptide binding]; other site 682795009820 ligand binding site [chemical binding]; other site 682795009821 Family of unknown function (DUF706); Region: DUF706; pfam05153 682795009822 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 682795009823 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 682795009824 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 682795009825 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 682795009826 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 682795009827 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 682795009828 beta-galactosidase; Region: BGL; TIGR03356 682795009829 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 682795009830 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795009831 Transposase domain (DUF772); Region: DUF772; pfam05598 682795009832 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 682795009833 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 682795009834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795009835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795009836 DNA binding site [nucleotide binding] 682795009837 domain linker motif; other site 682795009838 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795009839 ligand binding site [chemical binding]; other site 682795009840 dimerization interface [polypeptide binding]; other site 682795009841 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 682795009842 putative iron binding site [ion binding]; other site 682795009843 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 682795009844 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 682795009845 putative metal binding site; other site 682795009846 short chain dehydrogenase; Provisional; Region: PRK07774 682795009847 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 682795009848 NADP binding site [chemical binding]; other site 682795009849 substrate binding site [chemical binding]; other site 682795009850 active site 682795009851 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 682795009852 active site 682795009853 enoyl-CoA hydratase; Provisional; Region: PRK05995 682795009854 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 682795009855 substrate binding site [chemical binding]; other site 682795009856 oxyanion hole (OAH) forming residues; other site 682795009857 trimer interface [polypeptide binding]; other site 682795009858 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 682795009859 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 682795009860 active site 682795009861 catalytic residues [active] 682795009862 metal binding site [ion binding]; metal-binding site 682795009863 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 682795009864 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 682795009865 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 682795009866 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 682795009867 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 682795009868 Isochorismatase family; Region: Isochorismatase; pfam00857 682795009869 catalytic triad [active] 682795009870 metal binding site [ion binding]; metal-binding site 682795009871 conserved cis-peptide bond; other site 682795009872 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 682795009873 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 682795009874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795009875 non-specific DNA binding site [nucleotide binding]; other site 682795009876 salt bridge; other site 682795009877 sequence-specific DNA binding site [nucleotide binding]; other site 682795009878 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 682795009879 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 682795009880 catalytic residue [active] 682795009881 putative FPP diphosphate binding site; other site 682795009882 putative FPP binding hydrophobic cleft; other site 682795009883 dimer interface [polypeptide binding]; other site 682795009884 putative IPP diphosphate binding site; other site 682795009885 DinB superfamily; Region: DinB_2; pfam12867 682795009886 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 682795009887 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 682795009888 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 682795009889 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 682795009890 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 682795009891 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 682795009892 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 682795009893 RIP metalloprotease RseP; Region: TIGR00054 682795009894 active site 682795009895 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 682795009896 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 682795009897 protein binding site [polypeptide binding]; other site 682795009898 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 682795009899 putative substrate binding region [chemical binding]; other site 682795009900 Predicted transcriptional regulator [Transcription]; Region: COG3905 682795009901 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 682795009902 CAAX protease self-immunity; Region: Abi; pfam02517 682795009903 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 682795009904 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 682795009905 active site 682795009906 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 682795009907 Predicted integral membrane protein [Function unknown]; Region: COG5617 682795009908 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 682795009909 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 682795009910 substrate binding pocket [chemical binding]; other site 682795009911 chain length determination region; other site 682795009912 substrate-Mg2+ binding site; other site 682795009913 catalytic residues [active] 682795009914 aspartate-rich region 1; other site 682795009915 active site lid residues [active] 682795009916 aspartate-rich region 2; other site 682795009917 Domain of unknown function DUF59; Region: DUF59; cl00941 682795009918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795009919 S-adenosylmethionine binding site [chemical binding]; other site 682795009920 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 682795009921 Uncharacterized conserved protein [Function unknown]; Region: COG0062 682795009922 putative carbohydrate kinase; Provisional; Region: PRK10565 682795009923 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 682795009924 putative substrate binding site [chemical binding]; other site 682795009925 putative ATP binding site [chemical binding]; other site 682795009926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 682795009927 cell division protein FtsZ; Validated; Region: PRK09330 682795009928 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 682795009929 nucleotide binding site [chemical binding]; other site 682795009930 SulA interaction site; other site 682795009931 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 682795009932 Cell division protein FtsA; Region: FtsA; smart00842 682795009933 Cell division protein FtsA; Region: FtsA; pfam14450 682795009934 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 682795009935 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 682795009936 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 682795009937 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 682795009938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 682795009939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 682795009940 Predicted acetyltransferase [General function prediction only]; Region: COG3393 682795009941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 682795009942 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 682795009943 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 682795009944 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 682795009945 active site 682795009946 homodimer interface [polypeptide binding]; other site 682795009947 cell division protein FtsW; Region: ftsW; TIGR02614 682795009948 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 682795009949 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 682795009950 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 682795009951 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 682795009952 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 682795009953 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 682795009954 Mg++ binding site [ion binding]; other site 682795009955 putative catalytic motif [active] 682795009956 putative substrate binding site [chemical binding]; other site 682795009957 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 682795009958 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 682795009959 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 682795009960 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 682795009961 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 682795009962 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 682795009963 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 682795009964 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 682795009965 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 682795009966 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 682795009967 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 682795009968 Cell division protein FtsL; Region: FtsL; cl11433 682795009969 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 682795009970 MraW methylase family; Region: Methyltransf_5; cl17771 682795009971 cell division protein MraZ; Reviewed; Region: PRK00326 682795009972 MraZ protein; Region: MraZ; pfam02381 682795009973 MraZ protein; Region: MraZ; pfam02381 682795009974 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 682795009975 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 682795009976 Secretin and TonB N terminus short domain; Region: STN; smart00965 682795009977 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 682795009978 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 682795009979 N-terminal plug; other site 682795009980 ligand-binding site [chemical binding]; other site 682795009981 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 682795009982 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 682795009983 TPP-binding site; other site 682795009984 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 682795009985 PYR/PP interface [polypeptide binding]; other site 682795009986 dimer interface [polypeptide binding]; other site 682795009987 TPP binding site [chemical binding]; other site 682795009988 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 682795009989 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 682795009990 trimer interface [polypeptide binding]; other site 682795009991 active site 682795009992 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 682795009993 IHF - DNA interface [nucleotide binding]; other site 682795009994 IHF dimer interface [polypeptide binding]; other site 682795009995 primosomal protein N' Region: priA; TIGR00595 682795009996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795009997 ATP binding site [chemical binding]; other site 682795009998 putative Mg++ binding site [ion binding]; other site 682795009999 helicase superfamily c-terminal domain; Region: HELICc; smart00490 682795010000 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 682795010001 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 682795010002 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 682795010003 AMP binding site [chemical binding]; other site 682795010004 metal binding site [ion binding]; metal-binding site 682795010005 active site 682795010006 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 682795010007 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 682795010008 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 682795010009 active site 682795010010 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 682795010011 Predicted acyl esterases [General function prediction only]; Region: COG2936 682795010012 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795010013 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 682795010014 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795010015 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 682795010016 metal ion-dependent adhesion site (MIDAS); other site 682795010017 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 682795010018 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 682795010019 Lipopolysaccharide-assembly; Region: LptE; pfam04390 682795010020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795010021 Coenzyme A binding pocket [chemical binding]; other site 682795010022 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 682795010023 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 682795010024 Zn binding site [ion binding]; other site 682795010025 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 682795010026 FtsH Extracellular; Region: FtsH_ext; pfam06480 682795010027 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 682795010028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795010029 Walker A motif; other site 682795010030 ATP binding site [chemical binding]; other site 682795010031 Walker B motif; other site 682795010032 Peptidase family M41; Region: Peptidase_M41; pfam01434 682795010033 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 682795010034 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 682795010035 Ligand Binding Site [chemical binding]; other site 682795010036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 682795010037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795010038 Coenzyme A binding pocket [chemical binding]; other site 682795010039 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 682795010040 substrate binding site; other site 682795010041 dimer interface; other site 682795010042 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 682795010043 homotrimer interaction site [polypeptide binding]; other site 682795010044 zinc binding site [ion binding]; other site 682795010045 CDP-binding sites; other site 682795010046 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 682795010047 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 682795010048 HIGH motif; other site 682795010049 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 682795010050 active site 682795010051 KMSKS motif; other site 682795010052 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 682795010053 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 682795010054 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 682795010055 catalytic residues [active] 682795010056 KpsF/GutQ family protein; Region: kpsF; TIGR00393 682795010057 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 682795010058 putative active site [active] 682795010059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 682795010060 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 682795010061 prolyl-tRNA synthetase; Provisional; Region: PRK09194 682795010062 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 682795010063 dimer interface [polypeptide binding]; other site 682795010064 motif 1; other site 682795010065 active site 682795010066 motif 2; other site 682795010067 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 682795010068 putative deacylase active site [active] 682795010069 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 682795010070 active site 682795010071 motif 3; other site 682795010072 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 682795010073 anticodon binding site; other site 682795010074 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 682795010075 Transglycosylase; Region: Transgly; pfam00912 682795010076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 682795010077 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 682795010078 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 682795010079 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 682795010080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795010081 putative substrate translocation pore; other site 682795010082 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 682795010083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 682795010084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795010085 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 682795010086 RNA binding site [nucleotide binding]; other site 682795010087 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 682795010088 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 682795010089 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 682795010090 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 682795010091 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 682795010092 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 682795010093 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 682795010094 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795010095 Predicted transcriptional regulators [Transcription]; Region: COG1695 682795010096 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 682795010097 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 682795010098 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 682795010099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 682795010100 dimerization interface [polypeptide binding]; other site 682795010101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795010102 dimer interface [polypeptide binding]; other site 682795010103 phosphorylation site [posttranslational modification] 682795010104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010105 ATP binding site [chemical binding]; other site 682795010106 Mg2+ binding site [ion binding]; other site 682795010107 G-X-G motif; other site 682795010108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795010109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010110 active site 682795010111 phosphorylation site [posttranslational modification] 682795010112 intermolecular recognition site; other site 682795010113 dimerization interface [polypeptide binding]; other site 682795010114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795010115 DNA binding site [nucleotide binding] 682795010116 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 682795010117 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 682795010118 malonyl-CoA binding site [chemical binding]; other site 682795010119 dimer interface [polypeptide binding]; other site 682795010120 active site 682795010121 product binding site; other site 682795010122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795010123 S-adenosylmethionine binding site [chemical binding]; other site 682795010124 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 682795010125 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 682795010126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795010127 YceI-like domain; Region: YceI; pfam04264 682795010128 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 682795010129 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 682795010130 Multicopper oxidase; Region: Cu-oxidase; pfam00394 682795010131 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 682795010132 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 682795010133 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 682795010134 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 682795010135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795010136 S-adenosylmethionine binding site [chemical binding]; other site 682795010137 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 682795010138 generic binding surface II; other site 682795010139 generic binding surface I; other site 682795010140 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 682795010141 putative catalytic site [active] 682795010142 putative metal binding site [ion binding]; other site 682795010143 putative phosphate binding site [ion binding]; other site 682795010144 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 682795010145 classical (c) SDRs; Region: SDR_c; cd05233 682795010146 NAD(P) binding site [chemical binding]; other site 682795010147 active site 682795010148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795010149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795010150 TIGR03118 family protein; Region: PEPCTERM_chp_1 682795010151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 682795010152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 682795010153 short chain dehydrogenase; Provisional; Region: PRK07806 682795010154 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 682795010155 NAD(P) binding site [chemical binding]; other site 682795010156 active site 682795010157 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 682795010158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 682795010159 rod shape-determining protein MreC; Provisional; Region: PRK13922 682795010160 rod shape-determining protein MreC; Region: MreC; pfam04085 682795010161 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 682795010162 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 682795010163 generic binding surface I; other site 682795010164 generic binding surface II; other site 682795010165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795010166 ATP binding site [chemical binding]; other site 682795010167 putative Mg++ binding site [ion binding]; other site 682795010168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 682795010169 nucleotide binding region [chemical binding]; other site 682795010170 ATP-binding site [chemical binding]; other site 682795010171 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 682795010172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795010173 non-specific DNA binding site [nucleotide binding]; other site 682795010174 salt bridge; other site 682795010175 sequence-specific DNA binding site [nucleotide binding]; other site 682795010176 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 682795010177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010178 active site 682795010179 phosphorylation site [posttranslational modification] 682795010180 intermolecular recognition site; other site 682795010181 dimerization interface [polypeptide binding]; other site 682795010182 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 682795010183 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 682795010184 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 682795010185 dimer interface [polypeptide binding]; other site 682795010186 decamer (pentamer of dimers) interface [polypeptide binding]; other site 682795010187 catalytic triad [active] 682795010188 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010189 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010190 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010191 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 682795010192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795010193 dimer interface [polypeptide binding]; other site 682795010194 phosphorylation site [posttranslational modification] 682795010195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010196 ATP binding site [chemical binding]; other site 682795010197 Mg2+ binding site [ion binding]; other site 682795010198 G-X-G motif; other site 682795010199 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795010200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010201 active site 682795010202 phosphorylation site [posttranslational modification] 682795010203 intermolecular recognition site; other site 682795010204 dimerization interface [polypeptide binding]; other site 682795010205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795010206 DNA binding site [nucleotide binding] 682795010207 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 682795010208 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 682795010209 Soluble P-type ATPase [General function prediction only]; Region: COG4087 682795010210 Response regulator receiver domain; Region: Response_reg; pfam00072 682795010211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010212 active site 682795010213 phosphorylation site [posttranslational modification] 682795010214 intermolecular recognition site; other site 682795010215 dimerization interface [polypeptide binding]; other site 682795010216 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 682795010217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 682795010218 putative active site [active] 682795010219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795010220 dimer interface [polypeptide binding]; other site 682795010221 phosphorylation site [posttranslational modification] 682795010222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010223 ATP binding site [chemical binding]; other site 682795010224 Mg2+ binding site [ion binding]; other site 682795010225 G-X-G motif; other site 682795010226 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 682795010227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010228 ATP binding site [chemical binding]; other site 682795010229 Mg2+ binding site [ion binding]; other site 682795010230 G-X-G motif; other site 682795010231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 682795010232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795010233 dimer interface [polypeptide binding]; other site 682795010234 phosphorylation site [posttranslational modification] 682795010235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010236 ATP binding site [chemical binding]; other site 682795010237 Mg2+ binding site [ion binding]; other site 682795010238 G-X-G motif; other site 682795010239 Response regulator receiver domain; Region: Response_reg; pfam00072 682795010240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010241 active site 682795010242 phosphorylation site [posttranslational modification] 682795010243 intermolecular recognition site; other site 682795010244 dimerization interface [polypeptide binding]; other site 682795010245 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 682795010246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010247 active site 682795010248 phosphorylation site [posttranslational modification] 682795010249 intermolecular recognition site; other site 682795010250 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 682795010251 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 682795010252 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 682795010253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010254 ATP binding site [chemical binding]; other site 682795010255 Mg2+ binding site [ion binding]; other site 682795010256 G-X-G motif; other site 682795010257 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 682795010258 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 682795010259 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 682795010260 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795010261 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795010262 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795010263 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 682795010264 Protein export membrane protein; Region: SecD_SecF; cl14618 682795010265 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795010266 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 682795010267 PA14 domain; Region: PA14; cl08459 682795010268 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 682795010269 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795010270 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 682795010271 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 682795010272 active site 682795010273 Zn binding site [ion binding]; other site 682795010274 carboxylesterase BioH; Provisional; Region: PRK10349 682795010275 Putative esterase; Region: Esterase; pfam00756 682795010276 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 682795010277 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 682795010278 structural tetrad; other site 682795010279 PQQ-like domain; Region: PQQ_2; pfam13360 682795010280 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795010281 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795010282 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010283 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 682795010284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795010285 dimer interface [polypeptide binding]; other site 682795010286 phosphorylation site [posttranslational modification] 682795010287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010288 ATP binding site [chemical binding]; other site 682795010289 Mg2+ binding site [ion binding]; other site 682795010290 G-X-G motif; other site 682795010291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795010292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010293 active site 682795010294 phosphorylation site [posttranslational modification] 682795010295 intermolecular recognition site; other site 682795010296 dimerization interface [polypeptide binding]; other site 682795010297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795010298 DNA binding site [nucleotide binding] 682795010299 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 682795010300 active site 682795010301 catalytic residues [active] 682795010302 metal binding site [ion binding]; metal-binding site 682795010303 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 682795010304 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 682795010305 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 682795010306 catalytic residue [active] 682795010307 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 682795010308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795010309 putative DNA binding site [nucleotide binding]; other site 682795010310 putative Zn2+ binding site [ion binding]; other site 682795010311 AsnC family; Region: AsnC_trans_reg; pfam01037 682795010312 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 682795010313 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 682795010314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795010315 FeS/SAM binding site; other site 682795010316 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 682795010317 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 682795010318 Amidohydrolase; Region: Amidohydro_5; pfam13594 682795010319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 682795010320 active site 682795010321 Methyltransferase domain; Region: Methyltransf_31; pfam13847 682795010322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795010323 S-adenosylmethionine binding site [chemical binding]; other site 682795010324 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 682795010325 B12 binding site [chemical binding]; other site 682795010326 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 682795010327 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795010328 FeS/SAM binding site; other site 682795010329 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010330 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010331 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 682795010332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795010333 putative substrate translocation pore; other site 682795010334 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 682795010335 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795010336 Domain of unknown function (DUF756); Region: DUF756; pfam05506 682795010337 Domain of unknown function (DUF756); Region: DUF756; pfam05506 682795010338 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795010339 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 682795010340 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795010341 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795010342 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795010343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795010344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795010345 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 682795010346 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010347 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795010348 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010349 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 682795010350 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010351 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010352 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 682795010353 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 682795010354 FAD binding domain; Region: FAD_binding_4; pfam01565 682795010355 Berberine and berberine like; Region: BBE; pfam08031 682795010356 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010357 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010358 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 682795010359 alpha-galactosidase; Region: PLN02808; cl17638 682795010360 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010361 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 682795010362 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 682795010363 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 682795010364 putative sugar binding sites [chemical binding]; other site 682795010365 Q-X-W motif; other site 682795010366 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 682795010367 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 682795010368 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 682795010369 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 682795010370 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 682795010371 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 682795010372 active site 682795010373 catalytic site [active] 682795010374 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 682795010375 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795010376 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795010377 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795010378 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 682795010379 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795010380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010381 active site 682795010382 phosphorylation site [posttranslational modification] 682795010383 intermolecular recognition site; other site 682795010384 dimerization interface [polypeptide binding]; other site 682795010385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795010386 DNA binding site [nucleotide binding] 682795010387 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 682795010388 HAMP domain; Region: HAMP; pfam00672 682795010389 dimerization interface [polypeptide binding]; other site 682795010390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795010391 dimer interface [polypeptide binding]; other site 682795010392 phosphorylation site [posttranslational modification] 682795010393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010394 ATP binding site [chemical binding]; other site 682795010395 Mg2+ binding site [ion binding]; other site 682795010396 G-X-G motif; other site 682795010397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795010398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010399 active site 682795010400 phosphorylation site [posttranslational modification] 682795010401 intermolecular recognition site; other site 682795010402 dimerization interface [polypeptide binding]; other site 682795010403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795010404 DNA binding site [nucleotide binding] 682795010405 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 682795010406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 682795010407 dimerization interface [polypeptide binding]; other site 682795010408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795010409 dimer interface [polypeptide binding]; other site 682795010410 phosphorylation site [posttranslational modification] 682795010411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010412 ATP binding site [chemical binding]; other site 682795010413 Mg2+ binding site [ion binding]; other site 682795010414 G-X-G motif; other site 682795010415 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010416 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795010417 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010418 NHL repeat; Region: NHL; pfam01436 682795010419 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 682795010420 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 682795010421 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 682795010422 Ferrochelatase; Region: Ferrochelatase; pfam00762 682795010423 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 682795010424 C-terminal domain interface [polypeptide binding]; other site 682795010425 active site 682795010426 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 682795010427 active site 682795010428 N-terminal domain interface [polypeptide binding]; other site 682795010429 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 682795010430 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 682795010431 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795010432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795010433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 682795010434 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 682795010435 substrate binding site [chemical binding]; other site 682795010436 active site 682795010437 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 682795010438 dimer interface [polypeptide binding]; other site 682795010439 substrate binding site [chemical binding]; other site 682795010440 metal binding sites [ion binding]; metal-binding site 682795010441 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 682795010442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 682795010443 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 682795010444 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 682795010445 acyl-activating enzyme (AAE) consensus motif; other site 682795010446 AMP binding site [chemical binding]; other site 682795010447 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 682795010448 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 682795010449 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 682795010450 active site 682795010451 TDP-binding site; other site 682795010452 acceptor substrate-binding pocket; other site 682795010453 homodimer interface [polypeptide binding]; other site 682795010454 Condensation domain; Region: Condensation; pfam00668 682795010455 acyltransferase PapA5; Provisional; Region: PRK09294 682795010456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 682795010457 active site 682795010458 Condensation domain; Region: Condensation; pfam00668 682795010459 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 682795010460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795010461 Walker A/P-loop; other site 682795010462 ATP binding site [chemical binding]; other site 682795010463 Q-loop/lid; other site 682795010464 ABC transporter signature motif; other site 682795010465 Walker B; other site 682795010466 D-loop; other site 682795010467 H-loop/switch region; other site 682795010468 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 682795010469 ABC-2 type transporter; Region: ABC2_membrane; cl17235 682795010470 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 682795010471 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 682795010472 homodimer interface [polypeptide binding]; other site 682795010473 active site 682795010474 TDP-binding site; other site 682795010475 acceptor substrate-binding pocket; other site 682795010476 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 682795010477 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 682795010478 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 682795010479 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 682795010480 Multicopper oxidase; Region: Cu-oxidase; pfam00394 682795010481 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 682795010482 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010483 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010484 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010485 SnoaL-like domain; Region: SnoaL_2; pfam12680 682795010486 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 682795010487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795010488 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 682795010489 conserved cys residue [active] 682795010490 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 682795010491 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 682795010492 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 682795010493 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 682795010494 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 682795010495 Moco binding site; other site 682795010496 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 682795010497 metal coordination site [ion binding]; other site 682795010498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 682795010499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795010500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 682795010501 dimerization interface [polypeptide binding]; other site 682795010502 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 682795010503 classical (c) SDRs; Region: SDR_c; cd05233 682795010504 NAD(P) binding site [chemical binding]; other site 682795010505 active site 682795010506 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 682795010507 homotrimer interaction site [polypeptide binding]; other site 682795010508 putative active site [active] 682795010509 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 682795010510 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 682795010511 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 682795010512 active site 682795010513 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 682795010514 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010515 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795010516 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795010517 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 682795010518 FOG: WD40 repeat [General function prediction only]; Region: COG2319 682795010519 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795010520 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010521 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795010522 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010523 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 682795010524 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 682795010525 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 682795010526 AAA ATPase domain; Region: AAA_16; pfam13191 682795010527 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 682795010528 Uncharacterized conserved protein [Function unknown]; Region: COG3410 682795010529 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 682795010530 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 682795010531 hypothetical protein; Provisional; Region: PRK05409 682795010532 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 682795010533 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 682795010534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795010535 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 682795010536 active site 682795010537 phosphorylation site [posttranslational modification] 682795010538 intermolecular recognition site; other site 682795010539 dimerization interface [polypeptide binding]; other site 682795010540 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795010541 DNA binding site [nucleotide binding] 682795010542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 682795010543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 682795010544 dimerization interface [polypeptide binding]; other site 682795010545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795010546 dimer interface [polypeptide binding]; other site 682795010547 phosphorylation site [posttranslational modification] 682795010548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795010549 ATP binding site [chemical binding]; other site 682795010550 Mg2+ binding site [ion binding]; other site 682795010551 G-X-G motif; other site 682795010552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795010553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795010554 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 682795010555 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795010556 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795010557 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795010558 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 682795010559 Protein export membrane protein; Region: SecD_SecF; cl14618 682795010560 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 682795010561 Protein export membrane protein; Region: SecD_SecF; cl14618 682795010562 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795010563 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 682795010564 Interdomain contacts; other site 682795010565 Cytokine receptor motif; other site 682795010566 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795010567 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 682795010568 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 682795010569 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 682795010570 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 682795010571 Glyco_18 domain; Region: Glyco_18; smart00636 682795010572 active site 682795010573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 682795010574 DsrE/DsrF-like family; Region: DrsE; pfam02635 682795010575 amino acid transporter; Region: 2A0306; TIGR00909 682795010576 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 682795010577 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 682795010578 substrate binding site [chemical binding]; other site 682795010579 ATP binding site [chemical binding]; other site 682795010580 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 682795010581 MarR family; Region: MarR_2; pfam12802 682795010582 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 682795010583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795010584 nucleotide binding site [chemical binding]; other site 682795010585 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 682795010586 aromatic chitin/cellulose binding site residues [chemical binding]; other site 682795010587 Glyco_18 domain; Region: Glyco_18; smart00636 682795010588 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 682795010589 active site 682795010590 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 682795010591 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010592 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 682795010593 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 682795010594 A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570 682795010595 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 682795010596 active site 682795010597 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 682795010598 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 682795010599 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 682795010600 acyl-activating enzyme (AAE) consensus motif; other site 682795010601 AMP binding site [chemical binding]; other site 682795010602 active site 682795010603 CoA binding site [chemical binding]; other site 682795010604 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 682795010605 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 682795010606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 682795010607 putative acyl-acceptor binding pocket; other site 682795010608 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 682795010609 metal binding site [ion binding]; metal-binding site 682795010610 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 682795010611 active site 682795010612 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 682795010613 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 682795010614 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 682795010615 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 682795010616 RNA binding surface [nucleotide binding]; other site 682795010617 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 682795010618 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 682795010619 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 682795010620 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795010621 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010622 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795010623 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 682795010624 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 682795010625 Protein of unknown function (DUF721); Region: DUF721; cl02324 682795010626 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 682795010627 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 682795010628 putative active site [active] 682795010629 Bacterial sugar transferase; Region: Bac_transf; pfam02397 682795010630 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 682795010631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795010632 active site 682795010633 motif I; other site 682795010634 motif II; other site 682795010635 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 682795010636 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 682795010637 putative active site [active] 682795010638 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 682795010639 trimer interface [polypeptide binding]; other site 682795010640 active site 682795010641 substrate binding site [chemical binding]; other site 682795010642 CoA binding site [chemical binding]; other site 682795010643 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 682795010644 active site 682795010645 metal binding site [ion binding]; metal-binding site 682795010646 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 682795010647 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 682795010648 substrate binding site; other site 682795010649 tetramer interface; other site 682795010650 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 682795010651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 682795010652 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 682795010653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795010654 FeS/SAM binding site; other site 682795010655 Protein of unknown function (DUF497); Region: DUF497; cl01108 682795010656 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 682795010657 dimer interface [polypeptide binding]; other site 682795010658 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795010659 metal binding site [ion binding]; metal-binding site 682795010660 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 682795010661 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 682795010662 DXD motif; other site 682795010663 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 682795010664 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 682795010665 catalytic residue [active] 682795010666 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 682795010667 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 682795010668 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 682795010669 Uncharacterized conserved protein [Function unknown]; Region: COG1479 682795010670 Protein of unknown function DUF262; Region: DUF262; pfam03235 682795010671 Protein of unknown function DUF262; Region: DUF262; pfam03235 682795010672 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 682795010673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 682795010674 GMP synthase; Reviewed; Region: guaA; PRK00074 682795010675 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 682795010676 AMP/PPi binding site [chemical binding]; other site 682795010677 candidate oxyanion hole; other site 682795010678 catalytic triad [active] 682795010679 potential glutamine specificity residues [chemical binding]; other site 682795010680 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 682795010681 ATP Binding subdomain [chemical binding]; other site 682795010682 Ligand Binding sites [chemical binding]; other site 682795010683 Dimerization subdomain; other site 682795010684 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 682795010685 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 682795010686 HIGH motif; other site 682795010687 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 682795010688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 682795010689 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 682795010690 active site 682795010691 KMSKS motif; other site 682795010692 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 682795010693 tRNA binding surface [nucleotide binding]; other site 682795010694 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 682795010695 endonuclease IV; Provisional; Region: PRK01060 682795010696 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 682795010697 AP (apurinic/apyrimidinic) site pocket; other site 682795010698 DNA interaction; other site 682795010699 Metal-binding active site; metal-binding site 682795010700 FAD binding domain; Region: FAD_binding_1; pfam00667 682795010701 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 682795010702 FAD binding pocket [chemical binding]; other site 682795010703 FAD binding motif [chemical binding]; other site 682795010704 catalytic residues [active] 682795010705 NAD binding pocket [chemical binding]; other site 682795010706 phosphate binding motif [ion binding]; other site 682795010707 beta-alpha-beta structure motif; other site 682795010708 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 682795010709 Phosphoesterase family; Region: Phosphoesterase; pfam04185 682795010710 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 682795010711 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 682795010712 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795010713 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795010714 DNA binding site [nucleotide binding] 682795010715 domain linker motif; other site 682795010716 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795010717 dimerization interface [polypeptide binding]; other site 682795010718 ligand binding site [chemical binding]; other site 682795010719 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795010720 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795010721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 682795010722 Transposase; Region: DEDD_Tnp_IS110; pfam01548 682795010723 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 682795010724 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795010725 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 682795010726 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 682795010727 Trp docking motif [polypeptide binding]; other site 682795010728 putative active site [active] 682795010729 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 682795010730 Catalytic domain of Protein Kinases; Region: PKc; cd00180 682795010731 active site 682795010732 ATP binding site [chemical binding]; other site 682795010733 substrate binding site [chemical binding]; other site 682795010734 activation loop (A-loop); other site 682795010735 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 682795010736 Prokaryotic RING finger family 2; Region: Prok-RING_2; pfam14445 682795010737 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 682795010738 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 682795010739 ATP binding site [chemical binding]; other site 682795010740 substrate interface [chemical binding]; other site 682795010741 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795010742 metal ion-dependent adhesion site (MIDAS); other site 682795010743 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 682795010744 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 682795010745 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 682795010746 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 682795010747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795010748 Walker A motif; other site 682795010749 ATP binding site [chemical binding]; other site 682795010750 Walker B motif; other site 682795010751 arginine finger; other site 682795010752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795010753 Walker A motif; other site 682795010754 ATP binding site [chemical binding]; other site 682795010755 Walker B motif; other site 682795010756 arginine finger; other site 682795010757 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 682795010758 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 682795010759 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 682795010760 phosphopeptide binding site; other site 682795010761 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 682795010762 Protein phosphatase 2C; Region: PP2C; pfam00481 682795010763 active site 682795010764 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 682795010765 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 682795010766 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 682795010767 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795010768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795010769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795010770 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 682795010771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795010772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795010773 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 682795010774 Predicted membrane protein [Function unknown]; Region: COG3918 682795010775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795010776 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 682795010777 TPR repeat; Region: TPR_11; pfam13414 682795010778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795010779 binding surface 682795010780 TPR motif; other site 682795010781 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 682795010782 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 682795010783 dockerin binding interface; other site 682795010784 aminotransferase; Validated; Region: PRK08175 682795010785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 682795010786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795010787 homodimer interface [polypeptide binding]; other site 682795010788 catalytic residue [active] 682795010789 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 682795010790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 682795010791 Coenzyme A binding pocket [chemical binding]; other site 682795010792 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 682795010793 Acylphosphatase; Region: Acylphosphatase; pfam00708 682795010794 HypF finger; Region: zf-HYPF; pfam07503 682795010795 HypF finger; Region: zf-HYPF; pfam07503 682795010796 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 682795010797 HupF/HypC family; Region: HupF_HypC; pfam01455 682795010798 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 682795010799 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 682795010800 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 682795010801 dimerization interface [polypeptide binding]; other site 682795010802 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 682795010803 ATP binding site [chemical binding]; other site 682795010804 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 682795010805 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 682795010806 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 682795010807 NifU-like domain; Region: NifU; pfam01106 682795010808 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 682795010809 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 682795010810 nickel binding site [ion binding]; other site 682795010811 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 682795010812 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 682795010813 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 682795010814 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 682795010815 G1 box; other site 682795010816 GTP/Mg2+ binding site [chemical binding]; other site 682795010817 Switch I region; other site 682795010818 G3 box; other site 682795010819 Switch II region; other site 682795010820 G4 box; other site 682795010821 G5 box; other site 682795010822 High-affinity nickel-transport protein; Region: NicO; cl00964 682795010823 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 682795010824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795010825 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795010826 DNA binding residues [nucleotide binding] 682795010827 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 682795010828 Proline dehydrogenase; Region: Pro_dh; cl03282 682795010829 RHS Repeat; Region: RHS_repeat; cl11982 682795010830 RHS Repeat; Region: RHS_repeat; pfam05593 682795010831 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 682795010832 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 682795010833 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 682795010834 Ligand binding site; other site 682795010835 Ligand binding site; other site 682795010836 Ligand binding site; other site 682795010837 Putative Catalytic site; other site 682795010838 DXD motif; other site 682795010839 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 682795010840 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 682795010841 tandem repeat interface [polypeptide binding]; other site 682795010842 oligomer interface [polypeptide binding]; other site 682795010843 active site residues [active] 682795010844 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 682795010845 IHF dimer interface [polypeptide binding]; other site 682795010846 IHF - DNA interface [nucleotide binding]; other site 682795010847 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 682795010848 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 682795010849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795010850 Walker A/P-loop; other site 682795010851 ATP binding site [chemical binding]; other site 682795010852 Q-loop/lid; other site 682795010853 ABC transporter signature motif; other site 682795010854 Walker B; other site 682795010855 D-loop; other site 682795010856 H-loop/switch region; other site 682795010857 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 682795010858 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 682795010859 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 682795010860 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 682795010861 active site 682795010862 catalytic residue [active] 682795010863 dimer interface [polypeptide binding]; other site 682795010864 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 682795010865 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 682795010866 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 682795010867 shikimate binding site; other site 682795010868 NAD(P) binding site [chemical binding]; other site 682795010869 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 682795010870 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795010871 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 682795010872 Outer membrane efflux protein; Region: OEP; pfam02321 682795010873 Outer membrane efflux protein; Region: OEP; pfam02321 682795010874 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 682795010875 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 682795010876 active site 682795010877 Zn binding site [ion binding]; other site 682795010878 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 682795010879 substrate binding site [chemical binding]; other site 682795010880 putative active site [active] 682795010881 redox center [active] 682795010882 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 682795010883 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 682795010884 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 682795010885 tetramer interface [polypeptide binding]; other site 682795010886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795010887 catalytic residue [active] 682795010888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 682795010889 Uncharacterized conserved protein [Function unknown]; Region: COG1262 682795010890 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 682795010891 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 682795010892 Sulfatase; Region: Sulfatase; pfam00884 682795010893 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010894 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010895 Transcriptional regulators [Transcription]; Region: PurR; COG1609 682795010896 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 682795010897 DNA binding site [nucleotide binding] 682795010898 domain linker motif; other site 682795010899 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 682795010900 dimerization interface [polypeptide binding]; other site 682795010901 ligand binding site [chemical binding]; other site 682795010902 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010903 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010904 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 682795010905 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 682795010906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 682795010907 Putative glucoamylase; Region: Glycoamylase; pfam10091 682795010908 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 682795010909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795010910 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 682795010911 dimerization interface [polypeptide binding]; other site 682795010912 substrate binding pocket [chemical binding]; other site 682795010913 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 682795010914 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 682795010915 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 682795010916 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795010917 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 682795010918 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 682795010919 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 682795010920 nucleotide binding pocket [chemical binding]; other site 682795010921 K-X-D-G motif; other site 682795010922 catalytic site [active] 682795010923 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 682795010924 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 682795010925 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 682795010926 DNA binding site [nucleotide binding] 682795010927 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 682795010928 Dimer interface [polypeptide binding]; other site 682795010929 BRCT sequence motif; other site 682795010930 oxidative damage protection protein; Provisional; Region: PRK05408 682795010931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 682795010932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795010933 Walker A/P-loop; other site 682795010934 ATP binding site [chemical binding]; other site 682795010935 Q-loop/lid; other site 682795010936 ABC transporter signature motif; other site 682795010937 Walker B; other site 682795010938 D-loop; other site 682795010939 H-loop/switch region; other site 682795010940 Tetratricopeptide repeat; Region: TPR_12; pfam13424 682795010941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795010942 binding surface 682795010943 TPR motif; other site 682795010944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 682795010945 CHAT domain; Region: CHAT; pfam12770 682795010946 hypothetical protein; Provisional; Region: PRK09936 682795010947 Putative zinc-finger; Region: zf-HC2; pfam13490 682795010948 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795010949 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795010950 DNA binding residues [nucleotide binding] 682795010951 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 682795010952 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 682795010953 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 682795010954 Ca binding site [ion binding]; other site 682795010955 active site 682795010956 homodimer interface [polypeptide binding]; other site 682795010957 catalytic site [active] 682795010958 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795010959 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795010960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 682795010961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 682795010962 DNA binding site [nucleotide binding] 682795010963 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 682795010964 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 682795010965 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 682795010966 trimer interface [polypeptide binding]; other site 682795010967 active site 682795010968 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 682795010969 catalytic site [active] 682795010970 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795010971 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 682795010972 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795010973 Threonine dehydrogenase; Region: TDH; cd05281 682795010974 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 682795010975 structural Zn binding site [ion binding]; other site 682795010976 catalytic Zn binding site [ion binding]; other site 682795010977 tetramer interface [polypeptide binding]; other site 682795010978 NADP binding site [chemical binding]; other site 682795010979 Alginate lyase; Region: Alginate_lyase; pfam05426 682795010980 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 682795010981 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 682795010982 substrate-cofactor binding pocket; other site 682795010983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795010984 catalytic residue [active] 682795010985 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 682795010986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 682795010987 AAA domain; Region: AAA_33; pfam13671 682795010988 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 682795010989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 682795010990 Zn2+ binding site [ion binding]; other site 682795010991 Mg2+ binding site [ion binding]; other site 682795010992 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 682795010993 synthetase active site [active] 682795010994 NTP binding site [chemical binding]; other site 682795010995 metal binding site [ion binding]; metal-binding site 682795010996 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 682795010997 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 682795010998 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 682795010999 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 682795011000 TonB C terminal; Region: TonB_2; pfam13103 682795011001 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 682795011002 MPT binding site; other site 682795011003 trimer interface [polypeptide binding]; other site 682795011004 Predicted membrane protein [Function unknown]; Region: COG1238 682795011005 PEGA domain; Region: PEGA; pfam08308 682795011006 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 682795011007 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 682795011008 PEGA domain; Region: PEGA; pfam08308 682795011009 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011010 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795011011 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 682795011012 active site 682795011013 Zn binding site [ion binding]; other site 682795011014 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 682795011015 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 682795011016 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 682795011017 active site 682795011018 dimer interface [polypeptide binding]; other site 682795011019 effector binding site; other site 682795011020 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 682795011021 TSCPD domain; Region: TSCPD; pfam12637 682795011022 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 682795011023 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 682795011024 Walker A/P-loop; other site 682795011025 ATP binding site [chemical binding]; other site 682795011026 Q-loop/lid; other site 682795011027 ABC transporter signature motif; other site 682795011028 Walker B; other site 682795011029 D-loop; other site 682795011030 H-loop/switch region; other site 682795011031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795011032 DNA-binding site [nucleotide binding]; DNA binding site 682795011033 Uncharacterized conserved protein [Function unknown]; Region: COG2353 682795011034 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 682795011035 conserved cys residue [active] 682795011036 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 682795011037 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 682795011038 conserved cys residue [active] 682795011039 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 682795011040 homotrimer interaction site [polypeptide binding]; other site 682795011041 putative active site [active] 682795011042 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011043 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795011044 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795011045 integrase; Provisional; Region: int; PHA02601 682795011046 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 682795011047 active site 682795011048 DNA binding site [nucleotide binding] 682795011049 Int/Topo IB signature motif; other site 682795011050 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 682795011051 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 682795011052 Nitrogen regulatory protein P-II; Region: P-II; smart00938 682795011053 hypothetical protein; Reviewed; Region: PRK12497 682795011054 CTP synthetase; Validated; Region: pyrG; PRK05380 682795011055 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 682795011056 Catalytic site [active] 682795011057 active site 682795011058 UTP binding site [chemical binding]; other site 682795011059 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 682795011060 active site 682795011061 putative oxyanion hole; other site 682795011062 catalytic triad [active] 682795011063 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011064 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795011065 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795011066 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795011067 TPR repeat; Region: TPR_11; pfam13414 682795011068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795011069 binding surface 682795011070 TPR motif; other site 682795011071 TPR repeat; Region: TPR_11; pfam13414 682795011072 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 682795011073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 682795011074 ATP binding site [chemical binding]; other site 682795011075 putative Mg++ binding site [ion binding]; other site 682795011076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 682795011077 nucleotide binding region [chemical binding]; other site 682795011078 ATP-binding site [chemical binding]; other site 682795011079 DEAD/H associated; Region: DEAD_assoc; pfam08494 682795011080 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 682795011081 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 682795011082 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 682795011083 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 682795011084 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 682795011085 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 682795011086 RNB domain; Region: RNB; pfam00773 682795011087 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 682795011088 RNA binding site [nucleotide binding]; other site 682795011089 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 682795011090 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 682795011091 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795011092 Penicillinase repressor; Region: Pencillinase_R; pfam03965 682795011093 Beta-lactamase; Region: Beta-lactamase; pfam00144 682795011094 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 682795011095 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 682795011096 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 682795011097 RNA binding site [nucleotide binding]; other site 682795011098 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 682795011099 RNA binding site [nucleotide binding]; other site 682795011100 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 682795011101 RNA binding site [nucleotide binding]; other site 682795011102 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 682795011103 RNA binding site [nucleotide binding]; other site 682795011104 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 682795011105 RNA binding site [nucleotide binding]; other site 682795011106 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 682795011107 RNA binding site [nucleotide binding]; other site 682795011108 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 682795011109 nucleotide binding site/active site [active] 682795011110 HIT family signature motif; other site 682795011111 catalytic residue [active] 682795011112 SnoaL-like domain; Region: SnoaL_3; pfam13474 682795011113 Uncharacterized conserved protein [Function unknown]; Region: COG1359 682795011114 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 682795011115 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 682795011116 GDP-binding site [chemical binding]; other site 682795011117 ACT binding site; other site 682795011118 IMP binding site; other site 682795011119 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 682795011120 DinB superfamily; Region: DinB_2; pfam12867 682795011121 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 682795011122 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14810 682795011123 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 682795011124 DNA binding site [nucleotide binding] 682795011125 catalytic residue [active] 682795011126 H2TH interface [polypeptide binding]; other site 682795011127 putative catalytic residues [active] 682795011128 turnover-facilitating residue; other site 682795011129 intercalation triad [nucleotide binding]; other site 682795011130 8OG recognition residue [nucleotide binding]; other site 682795011131 putative reading head residues; other site 682795011132 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 682795011133 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 682795011134 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 682795011135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795011136 sequence-specific DNA binding site [nucleotide binding]; other site 682795011137 salt bridge; other site 682795011138 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 682795011139 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 682795011140 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 682795011141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 682795011142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795011143 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 682795011144 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 682795011145 thiamine phosphate binding site [chemical binding]; other site 682795011146 active site 682795011147 pyrophosphate binding site [ion binding]; other site 682795011148 FecR protein; Region: FecR; pfam04773 682795011149 Uncharacterized conserved protein [Function unknown]; Region: COG3391 682795011150 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 682795011151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795011152 Walker A/P-loop; other site 682795011153 ATP binding site [chemical binding]; other site 682795011154 Q-loop/lid; other site 682795011155 ABC transporter signature motif; other site 682795011156 Walker B; other site 682795011157 D-loop; other site 682795011158 H-loop/switch region; other site 682795011159 ABC transporter; Region: ABC_tran_2; pfam12848 682795011160 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 682795011161 CHASE3 domain; Region: CHASE3; pfam05227 682795011162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795011163 dimer interface [polypeptide binding]; other site 682795011164 phosphorylation site [posttranslational modification] 682795011165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795011166 ATP binding site [chemical binding]; other site 682795011167 Mg2+ binding site [ion binding]; other site 682795011168 G-X-G motif; other site 682795011169 Response regulator receiver domain; Region: Response_reg; pfam00072 682795011170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795011171 active site 682795011172 phosphorylation site [posttranslational modification] 682795011173 intermolecular recognition site; other site 682795011174 dimerization interface [polypeptide binding]; other site 682795011175 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 682795011176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795011177 active site 682795011178 phosphorylation site [posttranslational modification] 682795011179 intermolecular recognition site; other site 682795011180 dimerization interface [polypeptide binding]; other site 682795011181 PAS domain S-box; Region: sensory_box; TIGR00229 682795011182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 682795011183 putative active site [active] 682795011184 heme pocket [chemical binding]; other site 682795011185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 682795011186 dimer interface [polypeptide binding]; other site 682795011187 phosphorylation site [posttranslational modification] 682795011188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 682795011189 ATP binding site [chemical binding]; other site 682795011190 Mg2+ binding site [ion binding]; other site 682795011191 G-X-G motif; other site 682795011192 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 682795011193 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011194 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 682795011195 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 682795011196 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 682795011197 protein binding site [polypeptide binding]; other site 682795011198 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 682795011199 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 682795011200 CoA-binding site [chemical binding]; other site 682795011201 ATP-binding [chemical binding]; other site 682795011202 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 682795011203 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 682795011204 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 682795011205 homodimer interface [polypeptide binding]; other site 682795011206 NADP binding site [chemical binding]; other site 682795011207 substrate binding site [chemical binding]; other site 682795011208 putative phosphate acyltransferase; Provisional; Region: PRK05331 682795011209 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 682795011210 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 682795011211 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 682795011212 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 682795011213 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 682795011214 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 682795011215 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27); Region: Auto_anti-p27; cl00713 682795011216 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 682795011217 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 682795011218 active site 682795011219 H+ Antiporter protein; Region: 2A0121; TIGR00900 682795011220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011221 putative substrate translocation pore; other site 682795011222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011223 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 682795011224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795011225 non-specific DNA binding site [nucleotide binding]; other site 682795011226 salt bridge; other site 682795011227 sequence-specific DNA binding site [nucleotide binding]; other site 682795011228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795011229 TPR motif; other site 682795011230 binding surface 682795011231 short chain dehydrogenase; Provisional; Region: PRK06197 682795011232 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 682795011233 putative NAD(P) binding site [chemical binding]; other site 682795011234 active site 682795011235 Response regulator receiver domain; Region: Response_reg; pfam00072 682795011236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795011237 active site 682795011238 phosphorylation site [posttranslational modification] 682795011239 intermolecular recognition site; other site 682795011240 dimerization interface [polypeptide binding]; other site 682795011241 putative phosphoketolase; Provisional; Region: PRK05261 682795011242 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 682795011243 TPP-binding site; other site 682795011244 XFP C-terminal domain; Region: XFP_C; pfam09363 682795011245 Acetokinase family; Region: Acetate_kinase; cl17229 682795011246 propionate/acetate kinase; Provisional; Region: PRK12379 682795011247 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 682795011248 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 682795011249 HlyD family secretion protein; Region: HlyD_3; pfam13437 682795011250 YtkA-like; Region: YtkA; pfam13115 682795011251 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 682795011252 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 682795011253 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795011254 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 682795011255 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 682795011256 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 682795011257 protein binding site [polypeptide binding]; other site 682795011258 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 682795011259 Domain interface; other site 682795011260 Peptide binding site; other site 682795011261 Active site tetrad [active] 682795011262 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 682795011263 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 682795011264 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795011265 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 682795011266 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 682795011267 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 682795011268 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 682795011269 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 682795011270 active site 682795011271 FMN binding site [chemical binding]; other site 682795011272 substrate binding site [chemical binding]; other site 682795011273 homotetramer interface [polypeptide binding]; other site 682795011274 catalytic residue [active] 682795011275 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 682795011276 active site 682795011277 putative substrate binding region [chemical binding]; other site 682795011278 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 682795011279 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 682795011280 dimerization interface [polypeptide binding]; other site 682795011281 putative ATP binding site [chemical binding]; other site 682795011282 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 682795011283 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 682795011284 inhibitor-cofactor binding pocket; inhibition site 682795011285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795011286 catalytic residue [active] 682795011287 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 682795011288 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 682795011289 TolR protein; Region: tolR; TIGR02801 682795011290 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 682795011291 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795011292 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 682795011293 Protein export membrane protein; Region: SecD_SecF; pfam02355 682795011294 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 682795011295 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 682795011296 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 682795011297 Preprotein translocase subunit; Region: YajC; pfam02699 682795011298 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795011299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011300 putative substrate translocation pore; other site 682795011301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795011302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795011303 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795011304 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795011305 active site 682795011306 catalytic tetrad [active] 682795011307 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 682795011308 GIY-YIG motif/motif A; other site 682795011309 putative active site [active] 682795011310 putative metal binding site [ion binding]; other site 682795011311 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 682795011312 putative efflux protein, MATE family; Region: matE; TIGR00797 682795011313 cation binding site [ion binding]; other site 682795011314 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 682795011315 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 682795011316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795011317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795011318 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 682795011319 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 682795011320 oligomeric interface; other site 682795011321 putative active site [active] 682795011322 homodimer interface [polypeptide binding]; other site 682795011323 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 682795011324 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 682795011325 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 682795011326 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795011327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795011328 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 682795011329 DNA binding residues [nucleotide binding] 682795011330 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 682795011331 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011332 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795011333 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 682795011334 putative hydrophobic ligand binding site [chemical binding]; other site 682795011335 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 682795011336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795011337 S-adenosylmethionine binding site [chemical binding]; other site 682795011338 Predicted membrane protein [Function unknown]; Region: COG3918 682795011339 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 682795011340 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 682795011341 dimer interface [polypeptide binding]; other site 682795011342 active site 682795011343 glycine-pyridoxal phosphate binding site [chemical binding]; other site 682795011344 folate binding site [chemical binding]; other site 682795011345 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795011346 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 682795011347 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795011348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795011349 non-specific DNA binding site [nucleotide binding]; other site 682795011350 salt bridge; other site 682795011351 sequence-specific DNA binding site [nucleotide binding]; other site 682795011352 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 682795011353 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 682795011354 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 682795011355 active site 682795011356 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 682795011357 dimer interface [polypeptide binding]; other site 682795011358 substrate binding site [chemical binding]; other site 682795011359 catalytic residues [active] 682795011360 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 682795011361 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 682795011362 Peptidase family M48; Region: Peptidase_M48; cl12018 682795011363 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 682795011364 nucleotide binding site/active site [active] 682795011365 methionine sulfoxide reductase A; Provisional; Region: PRK14054 682795011366 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 682795011367 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 682795011368 nucleophile elbow; other site 682795011369 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 682795011370 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795011371 active site 682795011372 metal binding site [ion binding]; metal-binding site 682795011373 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 682795011374 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 682795011375 Walker A/P-loop; other site 682795011376 ATP binding site [chemical binding]; other site 682795011377 Q-loop/lid; other site 682795011378 ABC transporter signature motif; other site 682795011379 Walker B; other site 682795011380 D-loop; other site 682795011381 H-loop/switch region; other site 682795011382 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 682795011383 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 682795011384 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 682795011385 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 682795011386 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 682795011387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 682795011388 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011389 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 682795011390 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795011391 GTPase CgtA; Reviewed; Region: obgE; PRK12299 682795011392 GTP1/OBG; Region: GTP1_OBG; pfam01018 682795011393 Obg GTPase; Region: Obg; cd01898 682795011394 G1 box; other site 682795011395 GTP/Mg2+ binding site [chemical binding]; other site 682795011396 Switch I region; other site 682795011397 G2 box; other site 682795011398 G3 box; other site 682795011399 Switch II region; other site 682795011400 G4 box; other site 682795011401 G5 box; other site 682795011402 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 682795011403 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 682795011404 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 682795011405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795011406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795011407 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 682795011408 hydrophobic ligand binding site; other site 682795011409 Phospholipid methyltransferase; Region: PEMT; cl17370 682795011410 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 682795011411 prephenate dehydrogenase; Validated; Region: PRK08507 682795011412 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 682795011413 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 682795011414 putative catalytic cysteine [active] 682795011415 gamma-glutamyl kinase; Provisional; Region: PRK05429 682795011416 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 682795011417 nucleotide binding site [chemical binding]; other site 682795011418 homotetrameric interface [polypeptide binding]; other site 682795011419 putative phosphate binding site [ion binding]; other site 682795011420 putative allosteric binding site; other site 682795011421 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 682795011422 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 682795011423 Chorismate mutase type II; Region: CM_2; pfam01817 682795011424 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 682795011425 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 682795011426 substrate binding site [chemical binding]; other site 682795011427 active site 682795011428 catalytic residues [active] 682795011429 heterodimer interface [polypeptide binding]; other site 682795011430 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 682795011431 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 682795011432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 682795011433 catalytic residue [active] 682795011434 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 682795011435 active site 682795011436 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 682795011437 putative active site [active] 682795011438 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 682795011439 active site 682795011440 ribulose/triose binding site [chemical binding]; other site 682795011441 phosphate binding site [ion binding]; other site 682795011442 substrate (anthranilate) binding pocket [chemical binding]; other site 682795011443 product (indole) binding pocket [chemical binding]; other site 682795011444 aconitate hydratase; Validated; Region: PRK09277 682795011445 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 682795011446 substrate binding site [chemical binding]; other site 682795011447 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 682795011448 ligand binding site [chemical binding]; other site 682795011449 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 682795011450 substrate binding site [chemical binding]; other site 682795011451 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 682795011452 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 682795011453 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 682795011454 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 682795011455 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 682795011456 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 682795011457 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 682795011458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 682795011459 NAD(P) binding site [chemical binding]; other site 682795011460 active site 682795011461 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 682795011462 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 682795011463 Walker A/P-loop; other site 682795011464 ATP binding site [chemical binding]; other site 682795011465 Q-loop/lid; other site 682795011466 ABC transporter signature motif; other site 682795011467 Walker B; other site 682795011468 D-loop; other site 682795011469 H-loop/switch region; other site 682795011470 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 682795011471 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 682795011472 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 682795011473 Zn binding site [ion binding]; other site 682795011474 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 682795011475 trimer interface [polypeptide binding]; other site 682795011476 active site 682795011477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795011478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795011479 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 682795011480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 682795011481 Probable zinc-binding domain; Region: zf-trcl; pfam13451 682795011482 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 682795011483 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 682795011484 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 682795011485 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 682795011486 trimer interface [polypeptide binding]; other site 682795011487 putative metal binding site [ion binding]; other site 682795011488 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795011489 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795011490 active site 682795011491 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 682795011492 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 682795011493 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 682795011494 TPR repeat; Region: TPR_11; pfam13414 682795011495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 682795011496 binding surface 682795011497 TPR motif; other site 682795011498 Ferritin-like domain; Region: Ferritin; pfam00210 682795011499 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 682795011500 dinuclear metal binding motif [ion binding]; other site 682795011501 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 682795011502 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795011503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795011504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795011505 DNA binding residues [nucleotide binding] 682795011506 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 682795011507 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 682795011508 dimer interface [polypeptide binding]; other site 682795011509 motif 1; other site 682795011510 active site 682795011511 motif 2; other site 682795011512 motif 3; other site 682795011513 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 682795011514 anticodon binding site; other site 682795011515 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 682795011516 Aspartyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AspS; COG0173 682795011517 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 682795011518 dimer interface [polypeptide binding]; other site 682795011519 anticodon binding site; other site 682795011520 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 682795011521 homodimer interface [polypeptide binding]; other site 682795011522 motif 1; other site 682795011523 active site 682795011524 motif 2; other site 682795011525 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 682795011526 active site 682795011527 motif 3; other site 682795011528 Rhomboid family; Region: Rhomboid; cl11446 682795011529 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 682795011530 Peptidase family M28; Region: Peptidase_M28; pfam04389 682795011531 putative metal binding site [ion binding]; other site 682795011532 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 682795011533 Interdomain contacts; other site 682795011534 Cytokine receptor motif; other site 682795011535 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 682795011536 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011537 DNA polymerase IV; Validated; Region: PRK01810 682795011538 Y-family of DNA polymerases; Region: PolY; cd00424 682795011539 active site 682795011540 DNA binding site [nucleotide binding] 682795011541 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 682795011542 RDD family; Region: RDD; pfam06271 682795011543 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 682795011544 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 682795011545 Walker A/P-loop; other site 682795011546 ATP binding site [chemical binding]; other site 682795011547 Q-loop/lid; other site 682795011548 ABC transporter signature motif; other site 682795011549 Walker B; other site 682795011550 D-loop; other site 682795011551 H-loop/switch region; other site 682795011552 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 682795011553 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 682795011554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 682795011555 Histidine kinase; Region: HisKA_3; pfam07730 682795011556 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 682795011557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 682795011558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795011559 active site 682795011560 phosphorylation site [posttranslational modification] 682795011561 intermolecular recognition site; other site 682795011562 dimerization interface [polypeptide binding]; other site 682795011563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 682795011564 DNA binding residues [nucleotide binding] 682795011565 dimerization interface [polypeptide binding]; other site 682795011566 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 682795011567 active site 682795011568 HIGH motif; other site 682795011569 nucleotide binding site [chemical binding]; other site 682795011570 active site 682795011571 KMSKS motif; other site 682795011572 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 682795011573 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795011574 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795011575 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 682795011576 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 682795011577 active site 682795011578 HIGH motif; other site 682795011579 nucleotide binding site [chemical binding]; other site 682795011580 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 682795011581 KMSKS motif; other site 682795011582 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 682795011583 tRNA binding surface [nucleotide binding]; other site 682795011584 anticodon binding site; other site 682795011585 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 682795011586 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 682795011587 EamA-like transporter family; Region: EamA; pfam00892 682795011588 EamA-like transporter family; Region: EamA; pfam00892 682795011589 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011590 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795011591 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 682795011592 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 682795011593 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 682795011594 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 682795011595 Ligand binding site [chemical binding]; other site 682795011596 Electron transfer flavoprotein domain; Region: ETF; pfam01012 682795011597 NHL repeat; Region: NHL; pfam01436 682795011598 NHL repeat; Region: NHL; pfam01436 682795011599 NHL repeat; Region: NHL; pfam01436 682795011600 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 682795011601 Amidase; Region: Amidase; pfam01425 682795011602 MerC mercury resistance protein; Region: MerC; pfam03203 682795011603 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 682795011604 transmembrane helices; other site 682795011605 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 682795011606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011607 putative substrate translocation pore; other site 682795011608 sugar efflux transporter; Region: 2A0120; TIGR00899 682795011609 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 682795011610 Cysteine-rich domain; Region: CCG; pfam02754 682795011611 Cysteine-rich domain; Region: CCG; pfam02754 682795011612 Uncharacterized conserved protein [Function unknown]; Region: COG2968 682795011613 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 682795011614 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 682795011615 active site 682795011616 putative substrate binding region [chemical binding]; other site 682795011617 short chain dehydrogenase; Provisional; Region: PRK06180 682795011618 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 682795011619 NADP binding site [chemical binding]; other site 682795011620 active site 682795011621 steroid binding site; other site 682795011622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795011623 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795011624 active site 682795011625 metal binding site [ion binding]; metal-binding site 682795011626 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795011627 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 682795011628 active site 682795011629 metal binding site [ion binding]; metal-binding site 682795011630 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 682795011631 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 682795011632 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 682795011633 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 682795011634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795011635 S-adenosylmethionine binding site [chemical binding]; other site 682795011636 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 682795011637 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 682795011638 active site 682795011639 HIGH motif; other site 682795011640 dimer interface [polypeptide binding]; other site 682795011641 KMSKS motif; other site 682795011642 ScpA/B protein; Region: ScpA_ScpB; cl00598 682795011643 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 682795011644 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 682795011645 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 682795011646 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 682795011647 CoenzymeA binding site [chemical binding]; other site 682795011648 subunit interaction site [polypeptide binding]; other site 682795011649 PHB binding site; other site 682795011650 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 682795011651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 682795011652 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 682795011653 dimerization interface [polypeptide binding]; other site 682795011654 substrate binding pocket [chemical binding]; other site 682795011655 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 682795011656 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 682795011657 Ca binding site [ion binding]; other site 682795011658 active site 682795011659 catalytic site [active] 682795011660 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 682795011661 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795011662 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795011663 active site 682795011664 catalytic tetrad [active] 682795011665 Purine nucleoside permease (NUP); Region: NUP; pfam06516 682795011666 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 682795011667 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 682795011668 hypothetical protein; Provisional; Region: PRK06834 682795011669 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 682795011670 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 682795011671 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 682795011672 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 682795011673 putative ADP-ribose binding site [chemical binding]; other site 682795011674 putative active site [active] 682795011675 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 682795011676 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 682795011677 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 682795011678 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795011679 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 682795011680 active site 682795011681 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 682795011682 putative nucleotide binding site [chemical binding]; other site 682795011683 uridine monophosphate binding site [chemical binding]; other site 682795011684 homohexameric interface [polypeptide binding]; other site 682795011685 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 682795011686 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 682795011687 Predicted membrane protein [Function unknown]; Region: COG4818 682795011688 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 682795011689 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 682795011690 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 682795011691 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 682795011692 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 682795011693 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 682795011694 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 682795011695 active site 682795011696 Zn binding site [ion binding]; other site 682795011697 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 682795011698 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795011699 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 682795011700 mce related protein; Region: MCE; pfam02470 682795011701 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 682795011702 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 682795011703 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 682795011704 Walker A/P-loop; other site 682795011705 ATP binding site [chemical binding]; other site 682795011706 Q-loop/lid; other site 682795011707 ABC transporter signature motif; other site 682795011708 Walker B; other site 682795011709 D-loop; other site 682795011710 H-loop/switch region; other site 682795011711 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 682795011712 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795011713 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 682795011714 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 682795011715 Adenosylhomocysteinase; Provisional; Region: PTZ00075 682795011716 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 682795011717 homotetramer interface [polypeptide binding]; other site 682795011718 ligand binding site [chemical binding]; other site 682795011719 catalytic site [active] 682795011720 NAD binding site [chemical binding]; other site 682795011721 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 682795011722 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 682795011723 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 682795011724 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 682795011725 DNA binding site [nucleotide binding] 682795011726 active site 682795011727 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 682795011728 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 682795011729 S-adenosylmethionine synthetase; Validated; Region: PRK05250 682795011730 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 682795011731 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 682795011732 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 682795011733 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011734 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795011735 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795011736 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795011737 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011738 Helix-turn-helix domain; Region: HTH_25; pfam13413 682795011739 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795011740 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795011741 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 682795011742 FtsX-like permease family; Region: FtsX; pfam02687 682795011743 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 682795011744 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795011745 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795011746 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011747 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 682795011748 23S rRNA interface [nucleotide binding]; other site 682795011749 L3 interface [polypeptide binding]; other site 682795011750 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 682795011751 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 682795011752 rRNA interaction site [nucleotide binding]; other site 682795011753 S8 interaction site; other site 682795011754 putative laminin-1 binding site; other site 682795011755 elongation factor Ts; Reviewed; Region: tsf; PRK12332 682795011756 UBA/TS-N domain; Region: UBA; pfam00627 682795011757 Elongation factor TS; Region: EF_TS; pfam00889 682795011758 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 682795011759 hypothetical protein; Reviewed; Region: PRK09588 682795011760 NACHT domain; Region: NACHT; pfam05729 682795011761 HEAT repeats; Region: HEAT_2; pfam13646 682795011762 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795011763 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 682795011764 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 682795011765 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 682795011766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795011767 Walker A motif; other site 682795011768 ATP binding site [chemical binding]; other site 682795011769 Walker B motif; other site 682795011770 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 682795011771 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 682795011772 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 682795011773 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 682795011774 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795011775 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 682795011776 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 682795011777 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 682795011778 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 682795011779 FMN binding site [chemical binding]; other site 682795011780 active site 682795011781 catalytic residues [active] 682795011782 substrate binding site [chemical binding]; other site 682795011783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 682795011784 Protein of unknown function (DUF497); Region: DUF497; cl01108 682795011785 metal-dependent hydrolase; Provisional; Region: PRK13291 682795011786 DinB superfamily; Region: DinB_2; pfam12867 682795011787 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 682795011788 active site 682795011789 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795011790 protease TldD; Provisional; Region: tldD; PRK10735 682795011791 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 682795011792 hypothetical protein; Validated; Region: PRK07883 682795011793 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795011794 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795011795 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795011796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011797 putative substrate translocation pore; other site 682795011798 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 682795011799 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 682795011800 substrate binding site [chemical binding]; other site 682795011801 hexamer interface [polypeptide binding]; other site 682795011802 metal binding site [ion binding]; metal-binding site 682795011803 Outer membrane lipoprotein; Region: YfiO; pfam13525 682795011804 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 682795011805 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 682795011806 active site 682795011807 HIGH motif; other site 682795011808 nucleotide binding site [chemical binding]; other site 682795011809 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 682795011810 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 682795011811 active site 682795011812 KMSKS motif; other site 682795011813 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 682795011814 tRNA binding surface [nucleotide binding]; other site 682795011815 anticodon binding site; other site 682795011816 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 682795011817 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 682795011818 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 682795011819 active site 682795011820 metal binding site [ion binding]; metal-binding site 682795011821 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 682795011822 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 682795011823 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795011824 nucleotide binding site [chemical binding]; other site 682795011825 Type III pantothenate kinase; Region: Pan_kinase; cl17198 682795011826 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 682795011827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 682795011828 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 682795011829 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 682795011830 Competence protein; Region: Competence; pfam03772 682795011831 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 682795011832 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 682795011833 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795011834 exosortase J; Region: exosort_xrtJ; TIGR04199 682795011835 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 682795011836 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 682795011837 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 682795011838 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 682795011839 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 682795011840 glucokinase, proteobacterial type; Region: glk; TIGR00749 682795011841 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795011842 nucleotide binding site [chemical binding]; other site 682795011843 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 682795011844 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 682795011845 putative active site [active] 682795011846 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 682795011847 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 682795011848 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 682795011849 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 682795011850 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 682795011851 short chain dehydrogenase; Provisional; Region: PRK06180 682795011852 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 682795011853 NADP binding site [chemical binding]; other site 682795011854 active site 682795011855 steroid binding site; other site 682795011856 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 682795011857 tetramer (dimer of dimers) interface [polypeptide binding]; other site 682795011858 active site 682795011859 dimer interface [polypeptide binding]; other site 682795011860 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 682795011861 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 682795011862 TPP-binding site [chemical binding]; other site 682795011863 dimer interface [polypeptide binding]; other site 682795011864 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 682795011865 PYR/PP interface [polypeptide binding]; other site 682795011866 dimer interface [polypeptide binding]; other site 682795011867 TPP binding site [chemical binding]; other site 682795011868 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 682795011869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795011870 dimerization interface [polypeptide binding]; other site 682795011871 putative DNA binding site [nucleotide binding]; other site 682795011872 putative Zn2+ binding site [ion binding]; other site 682795011873 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 682795011874 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 682795011875 dimer interface [polypeptide binding]; other site 682795011876 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 682795011877 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 682795011878 Domain interface; other site 682795011879 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 682795011880 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 682795011881 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 682795011882 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 682795011883 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 682795011884 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 682795011885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 682795011886 sequence-specific DNA binding site [nucleotide binding]; other site 682795011887 salt bridge; other site 682795011888 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 682795011889 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 682795011890 G1 box; other site 682795011891 putative GEF interaction site [polypeptide binding]; other site 682795011892 GTP/Mg2+ binding site [chemical binding]; other site 682795011893 Switch I region; other site 682795011894 G2 box; other site 682795011895 G3 box; other site 682795011896 Switch II region; other site 682795011897 G4 box; other site 682795011898 G5 box; other site 682795011899 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 682795011900 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 682795011901 Uncharacterized conserved protein [Function unknown]; Region: COG2308 682795011902 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 682795011903 active site 682795011904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 682795011905 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 682795011906 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 682795011907 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 682795011908 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 682795011909 hypothetical protein; Validated; Region: PRK01415 682795011910 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 682795011911 active site residue [active] 682795011912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795011913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795011914 Isochorismatase family; Region: Isochorismatase; pfam00857 682795011915 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 682795011916 catalytic triad [active] 682795011917 conserved cis-peptide bond; other site 682795011918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011919 putative substrate translocation pore; other site 682795011920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 682795011921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011922 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 682795011923 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 682795011924 FtsX-like permease family; Region: FtsX; pfam02687 682795011925 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 682795011926 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 682795011927 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 682795011928 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 682795011929 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 682795011930 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 682795011931 putative active site [active] 682795011932 catalytic residue [active] 682795011933 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 682795011934 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 682795011935 5S rRNA interface [nucleotide binding]; other site 682795011936 CTC domain interface [polypeptide binding]; other site 682795011937 L16 interface [polypeptide binding]; other site 682795011938 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 682795011939 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 682795011940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 682795011941 active site 682795011942 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 682795011943 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 682795011944 putative active site [active] 682795011945 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 682795011946 Acid Phosphatase; Region: Acid_PPase; cl17256 682795011947 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 682795011948 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795011949 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 682795011950 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 682795011951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795011952 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795011953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011954 putative substrate translocation pore; other site 682795011955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795011956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 682795011957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 682795011958 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 682795011959 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 682795011960 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 682795011961 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 682795011962 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 682795011963 transaldolase-like protein; Provisional; Region: PTZ00411 682795011964 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 682795011965 active site 682795011966 dimer interface [polypeptide binding]; other site 682795011967 catalytic residue [active] 682795011968 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 682795011969 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 682795011970 Ligand binding site; other site 682795011971 Putative Catalytic site; other site 682795011972 DXD motif; other site 682795011973 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 682795011974 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 682795011975 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 682795011976 Predicted transcriptional regulators [Transcription]; Region: COG1695 682795011977 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 682795011978 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 682795011979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 682795011980 Walker A motif; other site 682795011981 ATP binding site [chemical binding]; other site 682795011982 Walker B motif; other site 682795011983 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 682795011984 Walker B motif; other site 682795011985 arginine finger; other site 682795011986 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 682795011987 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 682795011988 active site 682795011989 HslU subunit interaction site [polypeptide binding]; other site 682795011990 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795011991 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 682795011992 PA/protease or protease-like domain interface [polypeptide binding]; other site 682795011993 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795011994 Peptidase family M28; Region: Peptidase_M28; pfam04389 682795011995 metal binding site [ion binding]; metal-binding site 682795011996 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 682795011997 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 682795011998 minor groove reading motif; other site 682795011999 helix-hairpin-helix signature motif; other site 682795012000 substrate binding pocket [chemical binding]; other site 682795012001 active site 682795012002 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 682795012003 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 682795012004 DNA binding and oxoG recognition site [nucleotide binding] 682795012005 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 682795012006 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795012007 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795012008 active site 682795012009 catalytic tetrad [active] 682795012010 Protein of unknown function DUF72; Region: DUF72; pfam01904 682795012011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795012012 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 682795012013 putative substrate translocation pore; other site 682795012014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 682795012015 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 682795012016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 682795012017 motif II; other site 682795012018 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 682795012019 Putative zinc ribbon domain; Region: DUF164; pfam02591 682795012020 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 682795012021 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795012022 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795012023 active site 682795012024 catalytic tetrad [active] 682795012025 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 682795012026 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 682795012027 NAD binding site [chemical binding]; other site 682795012028 substrate binding site [chemical binding]; other site 682795012029 homodimer interface [polypeptide binding]; other site 682795012030 active site 682795012031 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 682795012032 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 682795012033 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 682795012034 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 682795012035 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 682795012036 HI0933-like protein; Region: HI0933_like; pfam03486 682795012037 malate dehydrogenase; Provisional; Region: PRK13529 682795012038 Malic enzyme, N-terminal domain; Region: malic; pfam00390 682795012039 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 682795012040 NAD(P) binding site [chemical binding]; other site 682795012041 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 682795012042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 682795012043 hypothetical protein; Provisional; Region: PRK02487 682795012044 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 682795012045 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 682795012046 putative RNA binding site [nucleotide binding]; other site 682795012047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 682795012048 S-adenosylmethionine binding site [chemical binding]; other site 682795012049 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 682795012050 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795012051 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 682795012052 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795012053 photolyase PhrII; Region: phr2; TIGR00591 682795012054 DNA photolyase; Region: DNA_photolyase; pfam00875 682795012055 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 682795012056 phosphogluconate dehydratase; Validated; Region: PRK09054 682795012057 6-phosphogluconate dehydratase; Region: edd; TIGR01196 682795012058 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 682795012059 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 682795012060 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 682795012061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795012062 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 682795012063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795012064 DNA binding residues [nucleotide binding] 682795012065 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795012066 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 682795012067 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 682795012068 Fic family protein [Function unknown]; Region: COG3177 682795012069 Fic/DOC family; Region: Fic; pfam02661 682795012070 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 682795012071 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 682795012072 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 682795012073 active site 682795012074 catalytic site [active] 682795012075 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 682795012076 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 682795012077 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 682795012078 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795012079 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 682795012080 arsenical-resistance protein; Region: acr3; TIGR00832 682795012081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 682795012082 dimerization interface [polypeptide binding]; other site 682795012083 putative DNA binding site [nucleotide binding]; other site 682795012084 putative Zn2+ binding site [ion binding]; other site 682795012085 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 682795012086 Low molecular weight phosphatase family; Region: LMWPc; cd00115 682795012087 active site 682795012088 Rhomboid family; Region: Rhomboid; pfam01694 682795012089 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 682795012090 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 682795012091 NAD binding site [chemical binding]; other site 682795012092 catalytic Zn binding site [ion binding]; other site 682795012093 structural Zn binding site [ion binding]; other site 682795012094 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 682795012095 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 682795012096 active site 682795012097 catalytic tetrad [active] 682795012098 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 682795012099 Zn binding site [ion binding]; other site 682795012100 Transcriptional regulators [Transcription]; Region: GntR; COG1802 682795012101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 682795012102 DNA-binding site [nucleotide binding]; DNA binding site 682795012103 FCD domain; Region: FCD; pfam07729 682795012104 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 682795012105 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 682795012106 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 682795012107 hydroxyglutarate oxidase; Provisional; Region: PRK11728 682795012108 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 682795012109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 682795012110 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 682795012111 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 682795012112 inhibitor site; inhibition site 682795012113 active site 682795012114 dimer interface [polypeptide binding]; other site 682795012115 catalytic residue [active] 682795012116 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795012117 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795012118 alpha-galactosidase; Region: PLN02808; cl17638 682795012119 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 682795012120 substrate binding site [chemical binding]; other site 682795012121 active site 682795012122 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 682795012123 ribulokinase; Provisional; Region: PRK04123 682795012124 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 682795012125 nucleotide binding site [chemical binding]; other site 682795012126 L-arabinose isomerase; Provisional; Region: PRK02929 682795012127 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 682795012128 hexamer (dimer of trimers) interface [polypeptide binding]; other site 682795012129 trimer interface [polypeptide binding]; other site 682795012130 substrate binding site [chemical binding]; other site 682795012131 Mn binding site [ion binding]; other site 682795012132 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 682795012133 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 682795012134 dimer interface [polypeptide binding]; other site 682795012135 NADP binding site [chemical binding]; other site 682795012136 catalytic residues [active] 682795012137 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 682795012138 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 682795012139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 682795012140 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 682795012141 Cytochrome P450; Region: p450; cl12078 682795012142 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 682795012143 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 682795012144 active site 682795012145 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 682795012146 SnoaL-like domain; Region: SnoaL_3; pfam13474 682795012147 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 682795012148 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 682795012149 homodimer interface [polypeptide binding]; other site 682795012150 active site 682795012151 TDP-binding site; other site 682795012152 acceptor substrate-binding pocket; other site 682795012153 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 682795012154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 682795012155 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 682795012156 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 682795012157 homodimer interface [polypeptide binding]; other site 682795012158 active site 682795012159 TDP-binding site; other site 682795012160 acceptor substrate-binding pocket; other site 682795012161 Protein of unknown function (DUF422); Region: DUF422; cl00991 682795012162 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 682795012163 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 682795012164 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 682795012165 glutaminase active site [active] 682795012166 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 682795012167 active site 682795012168 dimer interface [polypeptide binding]; other site 682795012169 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 682795012170 dimer interface [polypeptide binding]; other site 682795012171 active site 682795012172 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 682795012173 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 682795012174 active site 682795012175 dimer interface [polypeptide binding]; other site 682795012176 non-prolyl cis peptide bond; other site 682795012177 insertion regions; other site 682795012178 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 682795012179 ATP-grasp domain; Region: ATP-grasp_4; cl17255 682795012180 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 682795012181 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 682795012182 RES domain; Region: RES; pfam08808 682795012183 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 682795012184 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 682795012185 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 682795012186 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 682795012187 DEAD-like helicases superfamily; Region: DEXDc; smart00487 682795012188 ATP binding site [chemical binding]; other site 682795012189 Mg++ binding site [ion binding]; other site 682795012190 motif III; other site 682795012191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 682795012192 nucleotide binding region [chemical binding]; other site 682795012193 ATP-binding site [chemical binding]; other site 682795012194 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 682795012195 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 682795012196 active site 682795012197 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 682795012198 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 682795012199 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 682795012200 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 682795012201 N- and C-terminal domain interface [polypeptide binding]; other site 682795012202 D-xylulose kinase; Region: XylB; TIGR01312 682795012203 active site 682795012204 MgATP binding site [chemical binding]; other site 682795012205 catalytic site [active] 682795012206 metal binding site [ion binding]; metal-binding site 682795012207 xylulose binding site [chemical binding]; other site 682795012208 putative homodimer interface [polypeptide binding]; other site 682795012209 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 682795012210 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 682795012211 hexamer (dimer of trimers) interface [polypeptide binding]; other site 682795012212 trimer interface [polypeptide binding]; other site 682795012213 substrate binding site [chemical binding]; other site 682795012214 Mn binding site [ion binding]; other site 682795012215 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 682795012216 active site 682795012217 catalytic residues [active] 682795012218 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 682795012219 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 682795012220 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795012221 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 682795012222 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795012223 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 682795012224 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 682795012225 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 682795012226 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 682795012227 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 682795012228 Peptidase family M1; Region: Peptidase_M1; pfam01433 682795012229 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 682795012230 Zn binding site [ion binding]; other site 682795012231 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 682795012232 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 682795012233 Na binding site [ion binding]; other site 682795012234 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 682795012235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795012236 FeS/SAM binding site; other site 682795012237 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 682795012238 active site 682795012239 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 682795012240 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 682795012241 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 682795012242 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795012243 GTP-binding protein Der; Reviewed; Region: PRK00093 682795012244 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 682795012245 G1 box; other site 682795012246 GTP/Mg2+ binding site [chemical binding]; other site 682795012247 Switch I region; other site 682795012248 G2 box; other site 682795012249 Switch II region; other site 682795012250 G3 box; other site 682795012251 G4 box; other site 682795012252 G5 box; other site 682795012253 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 682795012254 G1 box; other site 682795012255 GTP/Mg2+ binding site [chemical binding]; other site 682795012256 Switch I region; other site 682795012257 G2 box; other site 682795012258 G3 box; other site 682795012259 Switch II region; other site 682795012260 G4 box; other site 682795012261 G5 box; other site 682795012262 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795012263 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795012264 Protein of unknown function (DUF497); Region: DUF497; pfam04365 682795012265 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 682795012266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 682795012267 active site 682795012268 phosphorylation site [posttranslational modification] 682795012269 intermolecular recognition site; other site 682795012270 dimerization interface [polypeptide binding]; other site 682795012271 LytTr DNA-binding domain; Region: LytTR; smart00850 682795012272 Double zinc ribbon; Region: DZR; pfam12773 682795012273 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 682795012274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 682795012275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 682795012276 DNA binding residues [nucleotide binding] 682795012277 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 682795012278 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 682795012279 Predicted transcriptional regulators [Transcription]; Region: COG1695 682795012280 Transcriptional regulator PadR-like family; Region: PadR; cl17335 682795012281 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 682795012282 active site 682795012283 ATP binding site [chemical binding]; other site 682795012284 substrate binding site [chemical binding]; other site 682795012285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795012286 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 682795012287 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 682795012288 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 682795012289 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 682795012290 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 682795012291 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 682795012292 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 682795012293 PA14 domain; Region: PA14; cl08459 682795012294 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 682795012295 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 682795012296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 682795012297 FeS/SAM binding site; other site 682795012298 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 682795012299 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 682795012300 metal ion-dependent adhesion site (MIDAS); other site 682795012301 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 682795012302 MutS domain III; Region: MutS_III; pfam05192 682795012303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 682795012304 Walker A/P-loop; other site 682795012305 ATP binding site [chemical binding]; other site 682795012306 Q-loop/lid; other site 682795012307 ABC transporter signature motif; other site 682795012308 Walker B; other site 682795012309 D-loop; other site 682795012310 H-loop/switch region; other site 682795012311 Smr domain; Region: Smr; pfam01713 682795012312 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 682795012313 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 682795012314 dimer interface [polypeptide binding]; other site 682795012315 active site 682795012316 Schiff base residues; other site 682795012317 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 682795012318 GIY-YIG motif/motif A; other site 682795012319 putative active site [active] 682795012320 putative metal binding site [ion binding]; other site 682795012321 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 682795012322 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 682795012323 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 682795012324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 682795012325 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 682795012326 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 682795012327 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 682795012328 E3 interaction surface; other site 682795012329 lipoyl attachment site [posttranslational modification]; other site 682795012330 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 682795012331 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 682795012332 E3 interaction surface; other site 682795012333 lipoyl attachment site [posttranslational modification]; other site 682795012334 e3 binding domain; Region: E3_binding; pfam02817 682795012335 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 682795012336 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 682795012337 HipA-like N-terminal domain; Region: HipA_N; pfam07805 682795012338 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 682795012339 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 682795012340 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 682795012341 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 682795012342 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 682795012343 YceG-like family; Region: YceG; pfam02618 682795012344 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 682795012345 dimerization interface [polypeptide binding]; other site 682795012346 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 682795012347 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 682795012348 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 682795012349 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 682795012350 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 682795012351 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 682795012352 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 682795012353 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 682795012354 active site 682795012355 (T/H)XGH motif; other site 682795012356 Oligomerisation domain; Region: Oligomerisation; pfam02410 682795012357 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795012358 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 682795012359 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795012360 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 682795012361 Cupin domain; Region: Cupin_2; cl17218 682795012362 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 682795012363 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 682795012364 IHF - DNA interface [nucleotide binding]; other site 682795012365 IHF dimer interface [polypeptide binding]; other site 682795012366 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 682795012367 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 682795012368 M28 Zn-Peptidases; Region: M28_like_4; cd08015 682795012369 Peptidase family M28; Region: Peptidase_M28; pfam04389 682795012370 metal binding site [ion binding]; metal-binding site 682795012371 Peptidase family M48; Region: Peptidase_M48; cl12018 682795012372 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 682795012373 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 682795012374 active site 682795012375 catalytic triad [active] 682795012376 oxyanion hole [active] 682795012377 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 682795012378 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 682795012379 Probable Catalytic site; other site 682795012380 metal-binding site 682795012381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 682795012382 active site 682795012383 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 682795012384 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 682795012385 active site 682795012386 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 682795012387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 682795012388 active site 682795012389 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 682795012390 Chain length determinant protein; Region: Wzz; cl15801 682795012391 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 682795012392 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 682795012393 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 682795012394 trmE is a tRNA modification GTPase; Region: trmE; cd04164 682795012395 G1 box; other site 682795012396 GTP/Mg2+ binding site [chemical binding]; other site 682795012397 Switch I region; other site 682795012398 G2 box; other site 682795012399 Switch II region; other site 682795012400 G3 box; other site 682795012401 G4 box; other site 682795012402 G5 box; other site 682795012403 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 682795012404 membrane protein insertase; Provisional; Region: PRK01318 682795012405 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 682795012406 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 682795012407 G-X-X-G motif; other site 682795012408 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 682795012409 RxxxH motif; other site 682795012410 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 682795012411 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 682795012412 putative NAD(P) binding site [chemical binding]; other site 682795012413 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 682795012414 putative active site [active] 682795012415 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 682795012416 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 682795012417 putative hydrophobic ligand binding site [chemical binding]; other site 682795012418 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 682795012419 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 682795012420 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 682795012421 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 682795012422 active site 682795012423 dimer interface [polypeptide binding]; other site 682795012424 motif 1; other site 682795012425 motif 2; other site 682795012426 motif 3; other site 682795012427 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 682795012428 anticodon binding site; other site 682795012429 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 682795012430 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 682795012431 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 682795012432 ParB-like nuclease domain; Region: ParBc; pfam02195 682795012433 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 682795012434 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 682795012435 P-loop; other site 682795012436 Magnesium ion binding site [ion binding]; other site 682795012437 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 682795012438 Magnesium ion binding site [ion binding]; other site 682795012439 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 682795012440 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 682795012441 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 682795012442 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 682795012443 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 682795012444 catalytic triad [active] 682795012445 Cytochrome c; Region: Cytochrom_C; cl11414 682795012446 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 682795012447 RuvA N terminal domain; Region: RuvA_N; pfam01330 682795012448 hypothetical protein; Validated; Region: PRK00041 682795012449 Ribonuclease P; Region: Ribonuclease_P; pfam00825 682795012450 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399