-- dump date   	20140619_104341
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_001289887.1	COG1629 Outer membrane receptor proteins, mostly Fe transport
YP_001289888.1	COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase
YP_001289889.1	periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate
YP_001289890.1	COG0500 SAM-dependent methyltransferases
YP_001289891.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_001289892.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_001289893.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_001289894.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_001289895.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_001289896.1	COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur
YP_001289897.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_001289898.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_001289899.1	COG2964 Uncharacterized protein conserved in bacteria
YP_001289900.1	COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1
YP_001289901.1	COG2900 Uncharacterized protein conserved in bacteria
YP_001289902.1	COG0678 Peroxiredoxin
YP_001289903.1	Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA
YP_001289904.1	negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis
YP_001289905.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_001289906.1	COG2183 Transcriptional accessory protein
YP_001289907.1	negatively supercoils closed circular double-stranded DNA
YP_001289908.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_001289909.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_001289911.1	COG2963 Transposase and inactivated derivatives
YP_001289912.1	COG2801 Transposase and inactivated derivatives
YP_001289913.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_001289914.1	transcriptional repressor of asnA which codes for aspartate-ammonia ligase
YP_001289915.1	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)
YP_001289916.1	COG1297 Predicted membrane protein
YP_001289917.1	COG1175 ABC-type sugar transport systems, permease components
YP_001289918.1	COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase
YP_001289919.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_001289920.1	COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase
YP_001289922.1	COG3309 Uncharacterized virulence-associated protein D
YP_001289923.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_001289924.1	COG0362 6-phosphogluconate dehydrogenase
YP_001289925.1	hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP
YP_001289926.1	COG3306 Glycosyltransferase involved in LPS biosynthesis
YP_001289927.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_001289928.1	COG0438 Glycosyltransferase
YP_001289929.1	COG3306 Glycosyltransferase involved in LPS biosynthesis
YP_001289930.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_001289931.1	COG0361 Translation initiation factor 1 (IF-1)
YP_001289932.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_001289933.1	binds single-stranded DNA at the primosome assembly site
YP_001289934.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_001289935.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_001289936.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_001289937.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_001289938.1	UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter
YP_001289939.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active
YP_001289940.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits
YP_001289941.1	involved in the assembly of the urease metallocenter; possible nickel donor
YP_001289942.1	COG0830 Urease accessory protein UreF
YP_001289943.1	COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase
YP_001289944.1	COG0829 Urease accessory protein UreH
YP_001289945.1	catalyzes the formation of fumarate from aspartate
YP_001289946.1	COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)
YP_001289947.1	synthesizes RNA primers at the replication forks
YP_001289948.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_001289949.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_001289950.1	catalyzes the formation of thymidine 5'-phosphate from thymidine
YP_001289951.1	COG0814 Amino acid permeases
YP_001289952.1	COG1145 Ferredoxin
YP_001289953.1	COG3719 Ribonuclease I
YP_001289954.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_001289955.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_001289956.1	COG1882 Pyruvate-formate lyase
YP_001289957.1	COG1180 Pyruvate-formate lyase-activating enzyme
YP_001289958.1	COG1972 Nucleoside permease
YP_001289959.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_001289960.1	binds directly to 23S ribosomal RNA
YP_001289961.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_001289962.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_001289963.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_001289964.1	COG1275 Tellurite resistance protein and related permeases
YP_001289965.1	COG1720 Uncharacterized conserved protein
YP_001289966.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_001289967.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_001289968.1	COG2862 Predicted membrane protein
YP_001289969.1	COG1609 Transcriptional regulators
YP_001289970.1	catalyzes the formation of D-ribose 5-phosphate from ribose
YP_001289971.1	periplasmic substrate-binding component of the ATP-dependent ribose transport system
YP_001289972.1	functions to transport ribose at high affinity; forms a complex with RbsA2C2B
YP_001289973.1	with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain
YP_001289974.1	cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source
YP_001289975.1	COG1322 Uncharacterized protein conserved in bacteria
YP_001289976.1	COG0665 Glycine/D-amino acid oxidases (deaminating)
YP_001289977.1	COG0665 Glycine/D-amino acid oxidases (deaminating)
YP_001289978.1	COG0687 Spermidine/putrescine-binding periplasmic protein
YP_001289979.1	heat shock protein involved in degradation of misfolded proteins
YP_001289980.1	heat shock protein involved in degradation of misfolded proteins
YP_001289981.1	Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity
YP_001289982.1	COG2801 Transposase and inactivated derivatives
YP_001289983.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_001289984.1	COG1238 Predicted membrane protein
YP_001289986.1	COG0637 Predicted phosphatase/phosphohexomutase
YP_001289987.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_001289988.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
YP_001289989.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_001289990.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_001289991.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_001289992.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_001289993.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_001289994.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_001289995.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_001289996.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_001289998.1	COG0814 Amino acid permeases
YP_001289999.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_001290000.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_001290001.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_001290002.1	catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate
YP_001290003.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_001290004.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_001290005.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_001290006.1	COG1561 Uncharacterized stress-induced protein
YP_001290007.1	COG0354 Predicted aminomethyltransferase related to GcvT
YP_001290008.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_001290009.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_001290010.1	COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases
YP_001290011.1	COG0466 ATP-dependent Lon protease, bacterial type
YP_001290012.1	COG2990 Uncharacterized protein conserved in bacteria
YP_001290013.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era
YP_001290014.1	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity
YP_001290015.1	COG0760 Parvulin-like peptidyl-prolyl isomerase
YP_001290016.1	COG1559 Predicted periplasmic solute-binding protein
YP_001290017.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_001290018.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_001290020.1	COG0084 Mg-dependent DNase
YP_001290021.1	COG1253 Hemolysins and related proteins containing CBS domains
YP_001290024.1	COG1191 DNA-directed RNA polymerase specialized sigma subunit
YP_001290025.1	phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr
YP_001290026.1	converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers
YP_001290027.1	COG3925 N-terminal domain of the phosphotransferase system fructose-specific component IIB
YP_001290028.1	COG1314 Preprotein translocase subunit SecG
YP_001290029.1	decatenates replicating daughter chromosomes
YP_001290030.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_001290031.1	COG0718 Uncharacterized protein conserved in bacteria
YP_001290032.1	COG2961 Protein involved in catabolism of external DNA
YP_001290033.1	COG5009 Membrane carboxypeptidase/penicillin-binding protein
YP_001290034.1	COG0133 Tryptophan synthase beta chain
YP_001290035.1	COG0419 ATPase involved in DNA repair
YP_001290037.1	COG1196 Chromosome segregation ATPases
YP_001290038.1	COG4796 Type II secretory pathway, component HofQ
YP_001290039.1	COG1040 Predicted amidophosphoribosyltransferases
YP_001290040.1	cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source
YP_001290041.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_001290042.1	COG3068 Uncharacterized protein conserved in bacteria
YP_001290043.1	COG0776 Bacterial nucleoid DNA-binding protein
YP_001290044.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_001290045.1	disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein
YP_001290046.1	Multifunctional regulator of fatty acid metabolism
YP_001290047.1	catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome
YP_001290048.1	COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes
YP_001290049.1	COG0566 rRNA methylases
YP_001290050.1	COG4123 Predicted O-methyltransferase
YP_001290051.1	facilitates an early step in the assembly of the 50S subunit of the ribosome
YP_001290053.1	COG0826 Collagenase and related proteases
YP_001290054.1	COG0477 Permeases of the major facilitator superfamily
YP_001290055.1	Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate
YP_001290056.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_001290057.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_001290058.1	COG2145 Hydroxyethylthiazole kinase, sugar kinase family
YP_001290059.1	COG1530 Ribonucleases G and E
YP_001290060.1	catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA
YP_001290061.1	Stimulates the elongation of poly(A) tails
YP_001290062.1	COG3283 Transcriptional regulator of aromatic amino acids metabolism
YP_001290063.1	COG0739 Membrane proteins related to metalloendopeptidases
YP_001290064.1	COG1121 ABC-type Mn/Zn transport systems, ATPase component
YP_001290065.1	COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
YP_001290066.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_001290067.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_001290068.1	COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
YP_001290069.1	MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair
YP_001290070.1	COG0350 Methylated DNA-protein cysteine methyltransferase
YP_001290071.1	COG2067 Long-chain fatty acid transport protein
YP_001290072.1	COG3691 Uncharacterized protein conserved in bacteria
YP_001290073.1	COG1409 Predicted phosphohydrolases
YP_001290074.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_001290075.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_001290076.1	COG2850 Uncharacterized conserved protein
YP_001290077.1	COG2914 Uncharacterized protein conserved in bacteria
YP_001290078.1	COG0193 Peptidyl-tRNA hydrolase
YP_001290079.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_001290080.1	COG0349 Ribonuclease D
YP_001290081.1	Activates fatty acids by binding to coenzyme A
YP_001290082.1	COG3065 Starvation-inducible outer membrane lipoprotein
YP_001290083.1	COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone
YP_001290084.1	COG1199 Rad3-related DNA helicases
YP_001290085.1	COG0824 Predicted thioesterase
YP_001290086.1	COG0811 Biopolymer transport proteins
YP_001290087.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_001290088.1	inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins
YP_001290089.1	forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_001290090.1	COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins
YP_001290091.1	COG1959 Predicted transcriptional regulator
YP_001290092.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_001290093.1	COG0822 NifU homolog involved in Fe-S cluster formation
YP_001290094.1	COG0316 Uncharacterized conserved protein
YP_001290095.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_001290096.1	COG1076 DnaJ-domain-containing proteins 1
YP_001290097.1	involved in the maturation of iron-sulfur cluster-containing proteins
YP_001290098.1	COG0633 Ferredoxin
YP_001290099.1	COG2975 Uncharacterized protein conserved in bacteria
YP_001290100.1	COG2976 Uncharacterized protein conserved in bacteria
YP_001290101.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_001290102.1	COG0124 Histidyl-tRNA synthetase
YP_001290103.1	COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis
YP_001290104.1	COG1426 Uncharacterized protein conserved in bacteria
YP_001290105.1	COG3063 Tfp pilus assembly protein PilF
YP_001290106.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_001290107.1	COG1686 D-alanyl-D-alanine carboxypeptidase
YP_001290108.1	COG3064 Membrane protein involved in colicin uptake
YP_001290109.1	COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
YP_001290110.1	COG1121 ABC-type Mn/Zn transport systems, ATPase component
YP_001290111.1	COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
YP_001290112.1	COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
YP_001290113.1	COG0819 Putative transcription activator
YP_001290114.1	COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
YP_001290115.1	COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
YP_001290117.1	COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
YP_001290118.1	COG1087 UDP-glucose 4-epimerase
YP_001290119.1	COG0477 Permeases of the major facilitator superfamily
YP_001290120.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_001290121.1	COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit
YP_001290122.1	COG3043 Nitrate reductase cytochrome c-type subunit
YP_001290123.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA
YP_001290124.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway
YP_001290125.1	periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC
YP_001290127.1	COG1145 Ferredoxin
YP_001290128.1	COG3171 Uncharacterized protein conserved in bacteria
YP_001290129.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_001290130.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_001290131.1	COG0628 Predicted permease
YP_001290132.1	COG0347 Nitrogen regulatory protein PII
YP_001290133.1	forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis
YP_001290134.1	COG0818 Diacylglycerol kinase
YP_001290135.1	COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
YP_001290136.1	COG1403 Restriction endonuclease
YP_001290137.1	COG0784 FOG: CheY-like receiver
YP_001290138.1	COG0326 Molecular chaperone, HSP90 family
YP_001290139.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_001290140.1	COG1381 Recombinational DNA repair protein (RecF pathway)
YP_001290141.1	COG0532 Translation initiation factor 2 (IF-2; GTPase)
YP_001290142.1	COG1509 Lysine 2,3-aminomutase
YP_001290143.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_001290144.1	COG3923 Primosomal replication protein N''
YP_001290145.1	Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A)
YP_001290146.1	COG0346 Lactoylglutathione lyase and related lyases
YP_001290147.1	COG1487 Predicted nucleic acid-binding protein, contains PIN domain
YP_001290148.1	COG4456 Virulence-associated protein and related proteins
YP_001290149.1	COG0500 SAM-dependent methyltransferases
YP_001290150.1	COG1755 Uncharacterized protein conserved in bacteria
YP_001290151.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_001290154.1	COG2932 Predicted transcriptional regulator
YP_001290155.1	COG2801 Transposase and inactivated derivatives
YP_001290157.1	COG1914 Mn2+ and Fe2+ transporters of the NRAMP family
YP_001290158.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_001290159.1	COG0217 Uncharacterized conserved protein
YP_001290160.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_001290161.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_001290162.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_001290163.1	COG1196 Chromosome segregation ATPases
YP_001290164.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_001290165.1	putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters
YP_001290166.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_001290167.1	Required for efficient pilin antigenic variation
YP_001290168.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_001290169.1	COG1678 Putative transcriptional regulator
YP_001290170.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_001290171.1	Transfers the fatty acyl group on membrane lipoproteins
YP_001290172.1	COG4535 Putative Mg2+ and Co2+ transporter CorC
YP_001290174.1	COG3023 Negative regulator of beta-lactamase expression
YP_001290175.1	COG4969 Tfp pilus assembly protein, major pilin PilA
YP_001290176.1	COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB
YP_001290177.1	COG1459 Type II secretory pathway, component PulF
YP_001290178.1	COG1835 Predicted acyltransferases
YP_001290179.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_001290180.1	when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis
YP_001290181.1	COG0789 Predicted transcriptional regulators
YP_001290182.1	COG2608 Copper chaperone
YP_001290183.1	COG2608 Copper chaperone
YP_001290184.1	COG2608 Copper chaperone
YP_001290185.1	COG2217 Cation transport ATPase
YP_001290186.1	COG0814 Amino acid permeases
YP_001290187.1	COG1760 L-serine deaminase
YP_001290188.1	COG0814 Amino acid permeases
YP_001290189.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_001290190.1	COG1169 Isochorismate synthase
YP_001290191.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_001290192.1	catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA
YP_001290193.1	COG0477 Permeases of the major facilitator superfamily
YP_001290194.1	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway
YP_001290195.1	COG2258 Uncharacterized protein conserved in bacteria
YP_001290196.1	COG3012 Uncharacterized protein conserved in bacteria
YP_001290197.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease
YP_001290198.1	COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
YP_001290199.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_001290200.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_001290201.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_001290202.1	functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system
YP_001290203.1	COG0042 tRNA-dihydrouridine synthase
YP_001290204.1	binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_001290205.1	COG4390 Uncharacterized protein conserved in bacteria
YP_001290206.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_001290207.1	COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific
YP_001290208.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_001290209.1	COG1539 Dihydroneopterin aldolase
YP_001290210.1	COG3210 Large exoproteins involved in heme utilization or adhesion
YP_001290211.1	COG2831 Hemolysin activation/secretion protein
YP_001290212.1	COG1629 Outer membrane receptor proteins, mostly Fe transport
YP_001290213.1	catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position
YP_001290214.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_001290216.1	COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases
YP_001290217.1	COG1544 Ribosome-associated protein Y (PSrp-1)
YP_001290218.1	COG3317 Uncharacterized lipoprotein
YP_001290219.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_001290220.1	bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine
YP_001290221.1	COG0811 Biopolymer transport proteins
YP_001290222.1	COG0848 Biopolymer transport protein
YP_001290223.1	COG0810 Periplasmic protein TonB, links inner and outer membranes
YP_001290224.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_001290225.1	COG3468 Type V secretory pathway, adhesin AidA
YP_001290226.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_001290227.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_001290228.1	COG0457 FOG: TPR repeat
YP_001290229.1	COG0425 Predicted redox protein, regulator of disulfide bond formation
YP_001290230.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_001290231.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_001290232.1	COG0628 Predicted permease
YP_001290233.1	COG1393 Arsenate reductase and related proteins, glutaredoxin family
YP_001290236.1	COG3036 Uncharacterized protein conserved in bacteria
YP_001290237.1	YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function
YP_001290238.1	COG0513 Superfamily II DNA and RNA helicases
YP_001290239.1	lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing
YP_001290240.1	COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)
YP_001290241.1	COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases
YP_001290242.1	COG2731 Beta-galactosidase, beta subunit
YP_001290243.1	COG1114 Branched-chain amino acid permeases
YP_001290244.1	exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
YP_001290245.1	COG1522 Transcriptional regulators
YP_001290246.1	COG2962 Predicted permeases
YP_001290247.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_001290248.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_001290249.1	catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon
YP_001290250.1	COG3223 Predicted membrane protein
YP_001290251.1	COG3071 Uncharacterized enzyme of heme biosynthesis
YP_001290252.1	COG2959 Uncharacterized enzyme of heme biosynthesis
YP_001290253.1	catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP
YP_001290254.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_001290255.1	catalyzes the O-acetylation of serine
YP_001290256.1	catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_001290257.1	COG0471 Di- and tricarboxylate transporters
YP_001290258.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_001290259.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_001290260.1	COG4154 Fucose dissimilation pathway protein FucU
YP_001290261.1	COG1070 Sugar (pentulose and hexulose) kinases
YP_001290262.1	catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose
YP_001290263.1	COG1349 Transcriptional regulators of sugar metabolism
YP_001290264.1	transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA
YP_001290265.1	COG0564 Pseudouridylate synthases, 23S RNA-specific
YP_001290266.1	COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
YP_001290267.1	COG1349 Transcriptional regulators of sugar metabolism
YP_001290268.1	COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen
YP_001290269.1	COG2011 ABC-type metal ion transport system, permease component
YP_001290270.1	part of the metNIQ transport system for methionine
YP_001290271.1	Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate
YP_001290279.1	catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate
YP_001290282.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_001290283.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_001290285.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_001290286.1	Essential for efficient processing of 16S rRNA
YP_001290287.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_001290288.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_001290289.1	Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_001290290.1	COG0730 Predicted permeases
YP_001290291.1	D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm
YP_001290292.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_001290293.1	small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS
YP_001290294.1	COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II
YP_001290295.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_001290296.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_001290297.1	COG0735 Fe2+/Zn2+ uptake regulation proteins
YP_001290298.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_001290299.1	COG0805 Sec-independent protein secretion pathway component TatC
YP_001290300.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_001290301.1	COG1826 Sec-independent protein secretion pathway components
YP_001290302.1	COG0789 Predicted transcriptional regulators
YP_001290303.1	COG1062 Zn-dependent alcohol dehydrogenases, class III
YP_001290304.1	COG0627 Predicted esterase
YP_001290305.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_001290306.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_001290307.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_001290308.1	Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm
YP_001290309.1	Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
YP_001290310.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_001290311.1	COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis
YP_001290312.1	COG2991 Uncharacterized protein conserved in bacteria
YP_001290313.1	COG1496 Uncharacterized conserved protein
YP_001290314.1	responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA
YP_001290315.1	COG4105 DNA uptake lipoprotein
YP_001290316.1	COG1882 Pyruvate-formate lyase
YP_001290317.1	COG2116 Formate/nitrite family of transporters
YP_001290318.1	catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine
YP_001290319.1	COG1940 Transcriptional regulator/sugar kinase
YP_001290320.1	COG1115 Na+/alanine symporter
YP_001290321.1	COG0271 Stress-induced morphogen (activity unknown)
YP_001290322.1	COG3056 Uncharacterized lipoprotein
YP_001290323.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_001290324.1	catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine
YP_001290325.1	COG1399 Predicted metal-binding, possibly nucleic acid-binding protein
YP_001290326.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_001290327.1	COG0333 Ribosomal protein L32
YP_001290328.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_001290329.1	COG0331 (acyl-carrier-protein) S-malonyltransferase
YP_001290330.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_001290331.1	carries the fatty acid chain in fatty acid biosynthesis
YP_001290332.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters
YP_001290333.1	COG2091 Phosphopantetheinyl transferase
YP_001290334.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_001290335.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_001290336.1	COG2020 Putative protein-S-isoprenylcysteine methyltransferase
YP_001290337.1	COG3055 Uncharacterized protein conserved in bacteria
YP_001290338.1	COG3090 TRAP-type C4-dicarboxylate transport system, small permease component
YP_001290339.1	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component
YP_001290340.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_001290341.1	catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein
YP_001290342.1	COG1737 Transcriptional regulators
YP_001290343.1	catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid
YP_001290344.1	catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate
YP_001290345.1	catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate
YP_001290346.1	COG3203 Outer membrane protein (porin)
YP_001290347.1	COG0328 Ribonuclease HI
YP_001290348.1	3'-5' exonuclease of DNA polymerase III
YP_001290349.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_001290350.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_001290351.1	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_001290354.1	COG0558 Phosphatidylglycerophosphate synthase
YP_001290355.1	catalyzes the formation of L-homocysteine from cystathionine
YP_001290356.1	COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases
YP_001290357.1	COG0773 UDP-N-acetylmuramate-alanine ligase
YP_001290358.1	COG5413 Uncharacterized integral membrane protein
YP_001290359.1	involved in transport of zinc(II) with ZnuA and C
YP_001290360.1	COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1
YP_001290361.1	membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_001290362.1	catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA
YP_001290363.1	COG0116 Predicted N6-adenine-specific DNA methylase
YP_001290364.1	COG2801 Transposase and inactivated derivatives
YP_001290365.1	COG0625 Glutathione S-transferase
YP_001290366.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001290367.1	COG0172 Seryl-tRNA synthetase
YP_001290368.1	COG2966 Uncharacterized conserved protein
YP_001290369.1	COG4536 Putative Mg2+ and Co2+ transporter CorB
YP_001290370.1	COG0541 Signal recognition particle GTPase
YP_001290371.1	COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
YP_001290372.1	COG0732 Restriction endonuclease S subunits
YP_001290373.1	COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen
YP_001290374.1	COG0286 Type I restriction-modification system methyltransferase subunit
YP_001290375.1	COG0327 Uncharacterized conserved protein
YP_001290376.1	molecular chaperone
YP_001290377.1	COG1393 Arsenate reductase and related proteins, glutaredoxin family
YP_001290378.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_001290379.1	COG1876 D-alanyl-D-alanine carboxypeptidase
YP_001290380.1	COG3842 ABC-type spermidine/putrescine transport systems, ATPase components
YP_001290382.1	COG1840 ABC-type Fe3+ transport system, periplasmic component
YP_001290383.1	COG0500 SAM-dependent methyltransferases
YP_001290384.1	COG2610 H+/gluconate symporter and related permeases
YP_001290385.1	COG1929 Glycerate kinase
YP_001290386.1	COG0325 Predicted enzyme with a TIM-barrel fold
YP_001290387.1	multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_001290388.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_001290389.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_001290390.1	catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity
YP_001290391.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001290393.1	COG0620 Methionine synthase II (cobalamin-independent)
YP_001290394.1	COG0084 Mg-dependent DNase
YP_001290395.1	COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
YP_001290396.1	COG2833 Uncharacterized protein conserved in bacteria
YP_001290397.1	COG1946 Acyl-CoA thioesterase
YP_001290398.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_001290399.1	COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase
YP_001290400.1	COG1708 Predicted nucleotidyltransferases
YP_001290401.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_001290402.1	catalyzes the phosphorylation of NAD to NADP
YP_001290403.1	COG0497 ATPase involved in DNA repair
YP_001290404.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_001290405.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_001290406.1	COG0860 N-acetylmuramoyl-L-alanine amidase
YP_001290407.1	COG0802 Predicted ATPase or kinase
YP_001290408.1	COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
YP_001290409.1	COG0617 tRNA nucleotidyltransferase/poly(A) polymerase
YP_001290411.1	COG1734 DnaK suppressor protein
YP_001290412.1	COG0658 Predicted membrane metal-binding protein
YP_001290413.1	involved in the transport of lipid A across the inner membrane
YP_001290414.1	transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_001290415.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_001290416.1	COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase
YP_001290417.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_001290418.1	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
YP_001290419.1	catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate
YP_001290420.1	COG2186 Transcriptional regulators
YP_001290421.1	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
YP_001290422.1	COG3090 TRAP-type C4-dicarboxylate transport system, small permease component
YP_001290423.1	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component
YP_001290424.1	COG0524 Sugar kinases, ribokinase family
YP_001290425.1	Converts D-mannonate to D-mannuronate
YP_001290426.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_001290427.1	COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism
YP_001290428.1	COG3054 Predicted transcriptional regulator
YP_001290429.1	COG0670 Integral membrane protein, interacts with FtsH
YP_001290430.1	COG3768 Predicted membrane protein
YP_001290431.1	COG0564 Pseudouridylate synthases, 23S RNA-specific
YP_001290432.1	removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction
YP_001290433.1	COG3076 Uncharacterized protein conserved in bacteria
YP_001290435.1	functions in MreBCD complex in some organisms
YP_001290436.1	COG4178 ABC-type uncharacterized transport system, permease and ATPase components
YP_001290437.1	COG2985 Predicted permease
YP_001290438.1	COG0799 Uncharacterized homolog of plant Iojap protein
YP_001290439.1	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_001290440.1	COG0768 Cell division protein FtsI/penicillin-binding protein 2
YP_001290441.1	COG0772 Bacterial cell division membrane protein
YP_001290442.1	COG0797 Lipoproteins
YP_001290443.1	COG1686 D-alanyl-D-alanine carboxypeptidase
YP_001290444.1	COG2921 Uncharacterized conserved protein
YP_001290445.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_001290446.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_001290447.1	COG3053 Citrate lyase synthetase
YP_001290448.1	acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate
YP_001290449.1	COG2301 Citrate lyase beta subunit
YP_001290450.1	COG3051 Citrate lyase, alpha subunit
YP_001290451.1	COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase)
YP_001290452.1	COG0471 Di- and tricarboxylate transporters
YP_001290453.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_001290454.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_001290455.1	stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit
YP_001290456.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_001290457.1	COG0681 Signal peptidase I
YP_001290458.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_001290459.1	16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit
YP_001290460.1	with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_001290461.1	alanine acetyltransferase that specifically acetylates ribosomal protein S18
YP_001290462.1	required for the formation of active formate dehydrogenase
YP_001290463.1	COG2864 Cytochrome b subunit of formate dehydrogenase
YP_001290464.1	COG0437 Fe-S-cluster-containing hydrogenase components 1
YP_001290465.1	COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
YP_001290466.1	COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
YP_001290467.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_001290468.1	COG0319 Predicted metal-dependent hydrolase
YP_001290469.1	COG0561 Predicted hydrolases of the HAD superfamily
YP_001290470.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_001290471.1	COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase
YP_001290472.1	Essential for recycling GMP and indirectly, cGMP
YP_001290473.1	promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_001290474.1	COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases
YP_001290475.1	catalyzes branch migration in Holliday junction intermediates
YP_001290476.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_001290477.1	flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration
YP_001290478.1	COG0583 Transcriptional regulator
YP_001290479.1	COG1296 Predicted branched-chain amino acid permease (azaleucine resistance)
YP_001290481.1	COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance)
YP_001290482.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_001290483.1	COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)
YP_001290484.1	COG2049 Allophanate hydrolase subunit 1
YP_001290485.1	COG1984 Allophanate hydrolase subunit 2
YP_001290486.1	COG1540 Uncharacterized proteins, homologs of lactam utilization protein B
YP_001290487.1	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_001290488.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_001290489.1	COG0744 Membrane carboxypeptidase (penicillin-binding protein)
YP_001290490.1	COG3112 Uncharacterized protein conserved in bacteria
YP_001290491.1	essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors
YP_001290492.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_001290493.1	COG2844 UTP:GlnB (protein PII) uridylyltransferase
YP_001290494.1	COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase
YP_001290495.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_001290496.1	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_001290497.1	COG1925 Phosphotransferase system, HPr-related proteins
YP_001290498.1	Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system
YP_001290499.1	functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose
YP_001290500.1	COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization
YP_001290501.1	COG3111 Uncharacterized conserved protein
YP_001290502.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_001290503.1	COG0642 Signal transduction histidine kinase
YP_001290504.1	COG1292 Choline-glycine betaine transporter
YP_001290505.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_001290506.1	COG0795 Predicted permeases
YP_001290507.1	COG0795 Predicted permeases
YP_001290508.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_001290509.1	COG1434 Uncharacterized conserved protein
YP_001290511.1	COG0438 Glycosyltransferase
YP_001290512.1	COG3306 Glycosyltransferase involved in LPS biosynthesis
YP_001290513.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001290514.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001290515.1	COG2005 N-terminal domain of molybdenum-binding protein
YP_001290516.1	COG0725 ABC-type molybdate transport system, periplasmic component
YP_001290517.1	part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE
YP_001290518.1	Part of the ABC transporter complex modABC involved in molybdenum import
YP_001290519.1	COG0733 Na+-dependent transporters of the SNF family
YP_001290520.1	COG0177 Predicted EndoIII-related endonuclease
YP_001290521.1	in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase
YP_001290522.1	part of membrane-bound complex hought to be involved in electron transport to nitrogen
YP_001290523.1	RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents
YP_001290524.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_001290525.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_001290526.1	COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA
YP_001290527.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_001290528.1	COG3110 Uncharacterized protein conserved in bacteria
YP_001290529.1	COG1289 Predicted membrane protein
YP_001290530.1	COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family
YP_001290531.1	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
YP_001290533.1	COG3210 Large exoproteins involved in heme utilization or adhesion
YP_001290534.1	COG0675 Transposase and inactivated derivatives
YP_001290535.1	COG1778 Low specificity phosphatase (HAD superfamily)
YP_001290536.1	COG0794 Predicted sugar phosphate isomerase involved in capsule formation
YP_001290537.1	Involved in anaerobic NO protection and iron metabolism
YP_001290538.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_001290539.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_001290540.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_001290541.1	COG0314 Molybdopterin converting factor, large subunit
YP_001290542.1	COG3008 Paraquat-inducible protein B
YP_001290543.1	COG2995 Uncharacterized paraquat-inducible protein A
YP_001290544.1	affects solute and DNA transport through an unknown mechanism
YP_001290545.1	Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3
YP_001290546.1	COG2989 Uncharacterized protein conserved in bacteria
YP_001290547.1	COG3108 Uncharacterized protein conserved in bacteria
YP_001290548.1	COG0084 Mg-dependent DNase
YP_001290549.1	COG0491 Zn-dependent hydrolases, including glyoxylases
YP_001290550.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_001290551.1	COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes
YP_001290552.1	B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA
YP_001290553.1	COG0208 Ribonucleotide reductase, beta subunit
YP_001290554.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_001290555.1	COG2823 Predicted periplasmic or secreted lipoprotein
YP_001290556.1	COG0279 Phosphoheptose isomerase
YP_001290557.1	COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase
YP_001290558.1	COG3107 Putative lipoprotein
YP_001290559.1	COG0313 Predicted methyltransferases
YP_001290560.1	COG0312 Predicted Zn-dependent proteases and their inactivated homologs
YP_001290561.1	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
YP_001290562.1	COG2801 Transposase and inactivated derivatives
YP_001290563.1	COG0513 Superfamily II DNA and RNA helicases
YP_001290564.1	component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent
YP_001290565.1	with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate
YP_001290566.1	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate
YP_001290567.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_001290568.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_001290569.1	COG3771 Predicted membrane protein
YP_001290570.1	COG2956 Predicted N-acetylglucosaminyl transferase
YP_001290571.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_001290572.1	involved in start site selection during the initiation of translation
YP_001290573.1	controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP
YP_001290574.1	COG2233 Xanthine/uracil permeases
YP_001290575.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_001290576.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_001290577.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_001290578.1	COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
YP_001290579.1	E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_001290580.1	COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes
YP_001290581.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_001290582.1	catalyzes the formation of methylglyoxal from glycerone phosphate
YP_001290584.1	COG5339 Uncharacterized protein conserved in bacteria
YP_001290585.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_001290586.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_001290588.1	COG2860 Predicted membrane protein
YP_001290589.1	Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance
YP_001290590.1	COG0477 Permeases of the major facilitator superfamily
YP_001290591.1	COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases
YP_001290592.1	COG3955 Exopolysaccharide biosynthesis protein
YP_001290593.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_001290598.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_001290601.1	COG1444 Predicted P-loop ATPase fused to an acetyltransferase
YP_001290602.1	COG1197 Transcription-repair coupling factor (superfamily II helicase)
YP_001290603.1	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_001290604.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_001290605.1	COG2949 Uncharacterized membrane protein
YP_001290606.1	Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine
YP_001290607.1	negatively supercoils closed circular double-stranded DNA
YP_001290608.1	COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
YP_001290609.1	COG1944 Uncharacterized conserved protein
YP_001290610.1	COG0500 SAM-dependent methyltransferases
YP_001290611.1	with TehA confers resistance to tellurite
YP_001290612.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_001290613.1	COG0489 ATPases involved in chromosome partitioning
YP_001290614.1	COG0778 Nitroreductase
YP_001290615.1	COG1083 CMP-N-acetylneuraminic acid synthetase
YP_001290618.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_001290619.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_001290620.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_001290622.1	COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases
YP_001290623.1	COG0732 Restriction endonuclease S subunits
YP_001290625.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_001290626.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_001290627.1	catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis
YP_001290628.1	related to GTP cyclohydrolase I; catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_001290629.1	COG5595 Zn-ribbon-containing, possibly nucleic-acid-binding protein
YP_001290630.1	COG2166 SufE protein probably involved in Fe-S center assembly
YP_001290631.1	COG0520 Selenocysteine lyase
YP_001290632.1	COG1525 Micrococcal nuclease (thermonuclease) homologs
YP_001290633.1	COG1380 Putative effector of murein hydrolase LrgA
YP_001290634.1	COG1346 Putative effector of murein hydrolase
YP_001290635.1	dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate
YP_001290636.1	Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
YP_001290637.1	COG0687 Spermidine/putrescine-binding periplasmic protein
YP_001290638.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component
YP_001290639.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component
YP_001290640.1	functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase
YP_001290641.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_001290642.1	COG0783 DNA-binding ferritin-like protein (oxidative damage protectant)
YP_001290643.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_001290644.1	COG0500 SAM-dependent methyltransferases
YP_001290645.1	COG0591 Na+/proline symporter
YP_001290646.1	involved in the processing of the 5'end of 16S rRNA
YP_001290647.1	catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001290648.1	COG2983 Uncharacterized conserved protein
YP_001290649.1	COG1640 4-alpha-glucanotransferase
YP_001290650.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_001290651.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_001290652.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_001290653.1	COG0058 Glucan phosphorylase
YP_001290654.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_001290655.1	COG0583 Transcriptional regulator
YP_001290656.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_001290658.1	COG1182 Acyl carrier protein phosphodiesterase
YP_001290659.1	catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001290660.1	COG0612 Predicted Zn-dependent peptidases
YP_001290661.1	COG3585 Molybdopterin-binding protein
YP_001290662.1	COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit
YP_001290663.1	COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
YP_001290664.1	acts with MukB and MukE to condense the chromosome and allow for segregation during cell division
YP_001290665.1	acts with MukB and MukF to condense the chromosome and allow for segregation during cell division
YP_001290666.1	COG3586 Uncharacterized conserved protein
YP_001290667.1	COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
YP_001290668.1	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
YP_001290669.1	COG0642 Signal transduction histidine kinase
YP_001290670.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_001290671.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_001290672.1	COG0581 ABC-type phosphate transport system, permease component
YP_001290673.1	COG0573 ABC-type phosphate transport system, permease component
YP_001290674.1	COG0226 ABC-type phosphate transport system, periplasmic component
YP_001290675.1	COG1528 Ferritin-like protein
YP_001290676.1	COG1528 Ferritin-like protein
YP_001290677.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001290678.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_001290679.1	TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity
YP_001290680.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_001290681.1	monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate
YP_001290682.1	COG0298 Hydrogenase maturation factor
YP_001290683.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_001290684.1	COG0525 Valyl-tRNA synthetase
YP_001290686.1	COG3097 Uncharacterized protein conserved in bacteria
YP_001290688.1	COG4185 Uncharacterized protein conserved in bacteria
YP_001290689.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_001290690.1	COG0136 Aspartate-semialdehyde dehydrogenase
YP_001290691.1	COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases
YP_001290692.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_001290693.1	COG0114 Fumarase
YP_001290694.1	COG0613 Predicted metal-dependent phosphoesterases (PHP family)
YP_001290695.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_001290696.1	COG0167 Dihydroorotate dehydrogenase
YP_001290697.1	COG1598 Uncharacterized conserved protein
YP_001290698.1	COG1724 Predicted periplasmic or secreted lipoprotein
YP_001290700.1	COG3646 Uncharacterized phage-encoded protein
YP_001290701.1	COG1396 Predicted transcriptional regulators
YP_001290702.1	COG1396 Predicted transcriptional regulators
YP_001290704.1	COG0419 ATPase involved in DNA repair
YP_001290711.1	COG3422 Uncharacterized conserved protein
YP_001290713.1	COG3561 Phage anti-repressor protein
YP_001290715.1	COG0582 Integrase
YP_001290718.1	Global transcription factor that controls the expression of over 100 target genes in response to anoxia
YP_001290719.1	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
YP_001290720.1	with UspC and UspD is involved in resistance to UV irradiation
YP_001290721.1	COG5266 ABC-type Co2+ transport system, periplasmic component
YP_001290722.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_001290723.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_001290724.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_001290725.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_001290726.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_001290727.1	COG2606 Uncharacterized conserved protein
YP_001290728.1	COG1278 Cold shock proteins
YP_001290729.1	COG3140 Uncharacterized protein conserved in bacteria
YP_001290730.1	catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp
YP_001290731.1	COG3098 Uncharacterized protein conserved in bacteria
YP_001290732.1	Required for the synthesis of the thiazole moiety
YP_001290733.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_001290734.1	COG0142 Geranylgeranyl pyrophosphate synthase
YP_001290735.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_001290736.1	COG2969 Stringent starvation protein B
YP_001290737.1	COG0625 Glutathione S-transferase
YP_001290738.1	forms a direct contact with the tRNA during translation
YP_001290739.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_001290740.1	MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor
YP_001290741.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_001290742.1	COG3100 Uncharacterized protein conserved in bacteria
YP_001290743.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_001290744.1	COG0303 Molybdopterin biosynthesis enzyme
YP_001290745.1	ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase
YP_001290746.1	highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein
YP_001290747.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001290748.1	COG0785 Cytochrome c biogenesis protein
YP_001290749.1	COG0225 Peptide methionine sulfoxide reductase
YP_001290751.1	COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
YP_001290752.1	Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_001290755.1	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog
YP_001290757.1	COG1538 Outer membrane protein
YP_001290758.1	COG0443 Molecular chaperone
YP_001290759.1	COG2062 Phosphohistidine phosphatase SixA
YP_001290760.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_001290761.1	COG0294 Dihydropteroate synthase and related enzymes
YP_001290762.1	COG0293 23S rRNA methylase
YP_001290763.1	COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
YP_001290764.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_001290765.1	penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_001290767.1	COG3676 Transposase and inactivated derivatives
YP_001290768.2	insertion of T, right before stop codon, leading to extension by 24 aa; marked partial
YP_001290769.1	COG0184 Ribosomal protein S15P/S13E
YP_001290770.1	COG0515 Serine/threonine protein kinase
YP_001290771.1	catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP
YP_001290772.1	COG1067 Predicted ATP-dependent protease
YP_001290773.1	COG3120 Uncharacterized protein conserved in bacteria
YP_001290774.1	COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member
YP_001290775.1	COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)
YP_001290776.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_001290777.1	COG0291 Ribosomal protein L35
YP_001290778.1	COG0290 Translation initiation factor 3 (IF-3)
YP_001290779.1	related to aldose 1-epimerase; COG0676 Uncharacterized enzymes related to aldose 1-epimerase
YP_001290781.1	COG0466 ATP-dependent Lon protease, bacterial type
YP_001290782.1	COG0631 Serine/threonine protein phosphatase
YP_001290783.1	COG0846 NAD-dependent protein deacetylases, SIR2 family
YP_001290784.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_001290786.1	COG3943 Virulence protein
YP_001290787.1	COG0462 Phosphoribosylpyrophosphate synthetase
YP_001290788.1	COG0846 NAD-dependent protein deacetylases, SIR2 family
YP_001290789.1	COG4502 Uncharacterized protein conserved in bacteria
YP_001290790.1	COG2378 Predicted transcriptional regulator
YP_001290791.1	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
YP_001290792.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_001290793.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_001290794.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_001290795.1	COG0016 Phenylalanyl-tRNA synthetase alpha subunit
YP_001290796.1	COG0633 Ferredoxin
YP_001290797.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_001290798.1	COG1280 Putative threonine efflux protein
YP_001290799.1	COG1267 Phosphatidylglycerophosphatase A and related proteins
YP_001290800.1	COG0611 Thiamine monophosphate kinase
YP_001290801.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_001290802.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_001290803.1	catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001290804.1	COG0288 Carbonic anhydrase
YP_001290806.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_001290807.1	catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose
YP_001290808.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_001290809.1	COG0786 Na+/glutamate symporter
YP_001290810.1	COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)
YP_001290811.1	functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase
YP_001290812.1	FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_001290813.1	catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules
YP_001290815.1	COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
YP_001290816.1	COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes
YP_001290817.1	COG0778 Nitroreductase
YP_001290818.1	COG3381 Uncharacterized component of anaerobic dehydrogenases
YP_001290819.1	COG2249 Putative NADPH-quinone reductase (modulator of drug activity B)
YP_001290820.1	involved in the import of serine and threonine coupled with the import of sodium
YP_001290821.1	COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases)
YP_001290822.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_001290823.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_001290824.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_001290825.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_001290826.1	COG0500 SAM-dependent methyltransferases
YP_001290827.1	COG2830 Uncharacterized protein conserved in bacteria
YP_001290828.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_001290829.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_001290830.1	COG4591 ABC-type transport system, involved in lipoprotein release, permease component
YP_001290831.1	Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor
YP_001290832.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_001290833.1	COG2912 Uncharacterized conserved protein
YP_001290834.1	COG2890 Methylase of polypeptide chain release factors
YP_001290835.1	COG1714 Predicted membrane protein/domain
YP_001290836.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_001290837.1	COG0790 FOG: TPR repeat, SEL1 subfamily
YP_001290838.1	COG0790 FOG: TPR repeat, SEL1 subfamily
YP_001290839.1	COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily)
YP_001290840.1	COG0790 FOG: TPR repeat, SEL1 subfamily
YP_001290841.1	COG3101 Uncharacterized protein conserved in bacteria
YP_001290844.1	COG5005 Mu-like prophage protein gpG
YP_001290846.1	COG4383 Mu-like prophage protein gp29
YP_001290847.1	COG0582 Integrase
YP_001290848.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_001290849.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_001290850.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_001290852.1	COG0166 Glucose-6-phosphate isomerase
YP_001290854.1	COG3133 Outer membrane lipoprotein
YP_001290855.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_001290856.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_001290857.1	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
YP_001290858.1	COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
YP_001290859.1	COG1757 Na+/H+ antiporter
YP_001290860.1	COG2916 DNA-binding protein H-NS
YP_001290861.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_001290862.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_001290863.1	COG0438 Glycosyltransferase
YP_001290864.1	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
YP_001290865.1	participates with LolB in the incorporation of lipoprotein into the outer membrane
YP_001290866.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_001290867.1	mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system
YP_001290868.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_001290869.1	COG3025 Uncharacterized conserved protein
YP_001290870.1	COG3210 Large exoproteins involved in heme utilization or adhesion
YP_001290871.1	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component
YP_001290872.1	COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family
YP_001290874.1	COG0675 Transposase and inactivated derivatives
YP_001290875.1	COG2801 Transposase and inactivated derivatives
YP_001290877.1	COG5566 Uncharacterized conserved protein
YP_001290878.1	COG3219 Uncharacterized protein conserved in bacteria
YP_001290879.1	COG3220 Uncharacterized protein conserved in bacteria
YP_001290880.1	COG3767 Uncharacterized low-complexity protein
YP_001290881.1	COG1392 Phosphate transport regulator (distant homolog of PhoU)
YP_001290882.1	COG0306 Phosphate/sulphate permeases
YP_001290883.1	COG3103 SH3 domain protein
YP_001290884.1	catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
YP_001290885.1	Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_001290886.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_001290887.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_001290888.1	Regulatory factor involved in maltose metabolism
YP_001290889.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_001290890.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_001290891.1	COG0308 Aminopeptidase N
YP_001290893.1	COG0024 Methionine aminopeptidase
YP_001290894.1	COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
YP_001290895.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_001290896.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_001290897.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_001290898.1	COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
YP_001290899.1	catalyzes the ATP-dependent transport of cobalt
YP_001290900.1	COG0013 Alanyl-tRNA synthetase
YP_001290901.1	COG5266 ABC-type Co2+ transport system, periplasmic component
YP_001290902.1	COG0789 Predicted transcriptional regulators
YP_001290903.1	COG0790 FOG: TPR repeat, SEL1 subfamily
YP_001290904.1	COG0251 Putative translation initiation inhibitor, yjgF family
YP_001290905.1	COG3105 Uncharacterized protein conserved in bacteria
YP_001290906.1	COG0586 Uncharacterized membrane-associated protein
YP_001290907.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_001290909.1	COG0527 Aspartokinases
YP_001290910.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_001290911.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_001290913.1	binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers
YP_001290914.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_001290915.1	COG2801 Transposase and inactivated derivatives
YP_001290916.1	COG2801 Transposase and inactivated derivatives
YP_001290917.1	COG0270 Site-specific DNA methylase
YP_001290918.1	COG3440 Predicted restriction endonuclease
YP_001290919.1	COG3106 Predicted ATPase
YP_001290920.1	COG4166 ABC-type oligopeptide transport system, periplasmic component
YP_001290921.1	COG4168 ABC-type antimicrobial peptide transport system, permease component
YP_001290922.1	COG4170 ABC-type antimicrobial peptide transport system, ATPase component
YP_001290923.1	COG4167 ABC-type antimicrobial peptide transport system, ATPase component
YP_001290924.1	COG2855 Predicted membrane protein
YP_001290925.1	catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate
YP_001290926.1	COG0158 Fructose-1,6-bisphosphatase
YP_001290927.1	COG1620 L-lactate permease
YP_001290928.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_001290929.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001290930.1	COG0608 Single-stranded DNA-specific exonuclease
YP_001290931.1	COG0608 Single-stranded DNA-specific exonuclease
YP_001290932.1	COG1651 Protein-disulfide isomerase
YP_001290933.1	COG1186 Protein chain release factor B
YP_001290934.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_001290935.1	oxidizes malate to oxaloacetate
YP_001290936.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_001290937.1	COG1090 Predicted nucleoside-diphosphate sugar epimerase
YP_001290938.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_001290939.1	COG3092 Uncharacterized protein conserved in bacteria
YP_001290940.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_001290941.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_001290942.1	COG2840 Uncharacterized protein conserved in bacteria
YP_001290943.1	involved in methylation of ribosomal protein L3
YP_001290944.1	LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation
YP_001290945.1	COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases
YP_001290946.1	COG0009 Putative translation factor (SUA5)
YP_001290947.1	COG0074 Succinyl-CoA synthetase, alpha subunit
YP_001290948.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_001290949.1	COG2933 Predicted SAM-dependent methyltransferase
YP_001290950.1	Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence
YP_001290951.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_001290952.1	COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
YP_001290953.1	COG0603 Predicted PP-loop superfamily ATPase
YP_001290954.1	COG0720 6-pyruvoyl-tetrahydropterin synthase
YP_001290955.1	COG0602 Organic radical activating enzymes
YP_001290956.1	COG0327 Uncharacterized conserved protein
YP_001290957.1	unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_001290958.1	COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
YP_001290959.1	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF
YP_001290960.1	Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides
YP_001290961.1	catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA
YP_001290962.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_001290963.1	With ArtMQJI transports arginine across the inner membrane
YP_001290964.1	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
YP_001290965.1	with ArtPMJI transports arginine across the inner membrane
YP_001290966.1	with ArtPQJI acts to transport arginine across the inner membrane
YP_001290967.1	COG5295 Autotransporter adhesin
YP_001290968.1	COG3637 Opacity protein and related surface antigens
YP_001290969.1	COG3091 Uncharacterized protein conserved in bacteria
YP_001290970.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_001290971.1	catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis
YP_001290972.1	catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine
YP_001290973.1	COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
YP_001290974.1	COG2926 Uncharacterized protein conserved in bacteria
YP_001290975.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_001290976.1	COG0278 Glutaredoxin-related protein
YP_001290977.1	COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins
YP_001290978.1	COG0277 FAD/FMN-containing dehydrogenases
YP_001290979.1	COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism
YP_001290980.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_001290981.1	COG3118 Thioredoxin domain-containing protein
YP_001290982.1	COG0492 Thioredoxin reductase
YP_001290983.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_001290984.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_001290985.1	activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions
YP_001290986.1	COG1823 Predicted Na+/dicarboxylate symporter
YP_001290987.1	COG1280 Putative threonine efflux protein
YP_001290988.1	COG0634 Hypoxanthine-guanine phosphoribosyltransferase
YP_001290989.1	COG0312 Predicted Zn-dependent proteases and their inactivated homologs
YP_001290990.1	COG3028 Uncharacterized protein conserved in bacteria
YP_001290991.1	COG3117 Uncharacterized protein conserved in bacteria
YP_001290992.1	COG1934 Uncharacterized protein conserved in bacteria
YP_001290993.1	COG1137 ABC-type (unclassified) transport system, ATPase component
YP_001290994.1	COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)
YP_001290995.1	COG1660 Predicted P-loop-containing kinase
YP_001290996.1	COG1605 Chorismate mutase
YP_001290997.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_001290998.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_001290999.1	COG1589 Cell division septal protein
YP_001291000.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_001291001.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_001291002.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_001291003.1	COG0772 Bacterial cell division membrane protein
YP_001291004.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_001291005.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_001291006.1	COG0770 UDP-N-acetylmuramyl pentapeptide synthase
YP_001291007.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_001291008.1	COG0768 Cell division protein FtsI/penicillin-binding protein 2
YP_001291009.1	COG3116 Cell division protein
YP_001291010.1	COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis
YP_001291011.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_001291012.1	COG1966 Carbon starvation protein, predicted membrane protein
YP_001291013.1	COG0777 Acetyl-CoA carboxylase beta subunit
YP_001291014.1	COG0176 Transaldolase
YP_001291015.1	COG4166 ABC-type oligopeptide transport system, periplasmic component
YP_001291016.1	COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
YP_001291017.1	COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components
YP_001291018.1	COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component
YP_001291019.1	COG4608 ABC-type oligopeptide transport system, ATPase component
YP_001291020.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_001291021.1	COG0606 Predicted ATPase with chaperone activity
YP_001291022.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_001291023.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001291024.1	catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose
YP_001291026.1	COG1070 Sugar (pentulose and hexulose) kinases
YP_001291027.1	catalyzes the interconversion of D-xylose to D-xylulose
YP_001291028.1	periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity
YP_001291029.1	COG4214 ABC-type xylose transport system, permease component
YP_001291030.1	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
YP_001291031.1	COG1757 Na+/H+ antiporter
YP_001291032.1	COG1609 Transcriptional regulators
YP_001291033.1	COG0859 ADP-heptose:LPS heptosyltransferase
YP_001291034.1	COG0477 Permeases of the major facilitator superfamily
YP_001291035.1	COG0031 Cysteine synthase
YP_001291036.1	putative role in sulfur assimilation
YP_001291037.1	interacts with cell division protein FitsZ and may be required to anchor septal ring structure
YP_001291038.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_001291041.1	COG0272 NAD-dependent DNA ligase (contains BRCT domain type II)
YP_001291042.1	COG4235 Cytochrome c biogenesis factor
YP_001291043.1	COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes
YP_001291044.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001291045.1	COG1138 Cytochrome c biogenesis factor
YP_001291046.1	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_001291047.1	COG3114 Heme exporter protein D
YP_001291048.1	COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component
YP_001291049.1	COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component
YP_001291050.1	ATP-binding protein; required for proper cytochrome c maturation
YP_001291051.1	COG0605 Superoxide dismutase
YP_001291052.1	COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component
YP_001291053.1	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component
YP_001291054.1	COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component
YP_001291055.1	COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component
YP_001291056.1	COG3113 Predicted NTP binding protein (contains STAS domain)
YP_001291057.1	COG5007 Predicted transcriptional regulator, BolA superfamily
YP_001291058.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_001291059.1	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
YP_001291060.1	COG1126 ABC-type polar amino acid transport system, ATPase component
YP_001291061.1	COG3201 Nicotinamide mononucleotide transporter
YP_001291062.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_001291063.1	COG0504 CTP synthase (UTP-ammonia lyase)
YP_001291064.1	COG1271 Cytochrome bd-type quinol oxidase, subunit 1
YP_001291066.1	COG1294 Cytochrome bd-type quinol oxidase, subunit 2
YP_001291067.1	COG2707 Predicted membrane protein
YP_001291068.1	COG2363 Uncharacterized small membrane protein
YP_001291069.1	involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
YP_001291070.1	COG0466 ATP-dependent Lon protease, bacterial type
YP_001291071.1	catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552
YP_001291072.1	part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia
YP_001291073.1	COG0437 Fe-S-cluster-containing hydrogenase components 1
YP_001291074.1	Catalyzes the phosphorylation of UMP to UDP
YP_001291075.1	COG2194 Predicted membrane-associated, metal-dependent hydrolase
YP_001291076.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_001291077.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_001291078.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_001291079.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_001291080.1	COG2189 Adenine specific DNA methylase Mod
YP_001291081.1	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
YP_001291082.1	COG2207 AraC-type DNA-binding domain-containing proteins
YP_001291083.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_001291085.1	COG2608 Copper chaperone
YP_001291086.1	COG1305 Transglutaminase-like enzymes, putative cysteine proteases
YP_001291087.1	COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing
YP_001291088.1	COG3302 DMSO reductase anchor subunit
YP_001291089.1	binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane
YP_001291095.1	responsible for the influx of magnesium ions
YP_001291096.1	putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_001291097.1	catalyzes the formation of serine from O-phosphoserine
YP_001291098.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_001291099.1	COG0502 Biotin synthase and related enzymes
YP_001291100.1	permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine
YP_001291101.1	COG4143 ABC-type thiamine transport system, periplasmic component
YP_001291102.1	COG1555 DNA uptake protein and related DNA-binding proteins
YP_001291103.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_001291104.1	COG0760 Parvulin-like peptidyl-prolyl isomerase
YP_001291105.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_001291106.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_001291107.1	COG0594 RNase P protein component
YP_001291108.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_001291110.1	COG0457 FOG: TPR repeat
YP_001291111.1	COG1629 Outer membrane receptor proteins, mostly Fe transport
YP_001291112.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_001291113.1	binds the polymerase to DNA and acts as a sliding clamp
YP_001291114.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_001291115.1	COG3468 Type V secretory pathway, adhesin AidA
YP_001291116.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_001291117.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_001291118.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_001291119.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_001291120.1	COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake
YP_001291122.1	COG3022 Uncharacterized protein conserved in bacteria
YP_001291123.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_001291124.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_001291125.1	Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription
YP_001291126.1	COG0042 tRNA-dihydrouridine synthase
YP_001291127.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_001291128.1	COG2184 Protein involved in cell division
YP_001291129.1	COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
YP_001291130.1	mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase
YP_001291131.1	COG3924 Predicted membrane protein
YP_001291132.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_001291133.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_001291134.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_001291135.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_001291136.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_001291137.1	COG0447 Dihydroxynaphthoic acid synthase
YP_001291138.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_001291139.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_001291140.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_001291141.1	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases
YP_001291142.1	COG5633 Predicted periplasmic lipoprotein
YP_001291143.1	hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_001291144.1	RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA
YP_001291145.1	complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons
YP_001291146.1	COG3089 Uncharacterized protein conserved in bacteria
YP_001291147.1	FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly
YP_001291148.1	catalyzes the formation of dUMP from dUTP
YP_001291149.1	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_001291150.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_001291151.1	required for 70S ribosome assembly
YP_001291152.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_001291153.1	catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde
YP_001291154.1	COG4456 Virulence-associated protein and related proteins
YP_001291155.1	COG1487 Predicted nucleic acid-binding protein, contains PIN domain
YP_001291156.1	COG0076 Glutamate decarboxylase and related PLP-dependent proteins
YP_001291157.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_001291158.1	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_001291159.1	COG0117 Pyrimidine deaminase
YP_001291160.1	COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains
YP_001291163.1	COG1330 Exonuclease V gamma subunit
YP_001291164.1	COG4795 Type II secretory pathway, component PulJ
YP_001291165.1	COG2165 Type II secretory pathway, pseudopilin PulG
YP_001291166.1	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
YP_001291167.1	COG1138 Cytochrome c biogenesis factor
YP_001291168.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001291169.1	COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes
YP_001291170.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_001291171.1	COG3210 Large exoproteins involved in heme utilization or adhesion
YP_001291172.1	COG0754 Glutathionylspermidine synthase
YP_001291173.1	COG0753 Catalase
YP_001291174.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001291175.1	COG4545 Glutaredoxin-related protein
YP_001291176.1	COG2852 Uncharacterized protein conserved in bacteria
YP_001291177.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001291180.1	COG0582 Integrase
YP_001291181.1	COG2161 Antitoxin of toxin-antitoxin stability system
YP_001291185.1	COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system
YP_001291186.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_001291187.1	COG2980 Rare lipoprotein B
YP_001291188.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_001291189.1	COG0020 Undecaprenyl pyrophosphate synthase
YP_001291190.1	COG0575 CDP-diglyceride synthetase
YP_001291191.1	COG0750 Predicted membrane-associated Zn-dependent proteases 1
YP_001291192.1	COG4775 Outer membrane protein/protective antigen OMA87
YP_001291193.1	COG2825 Outer membrane protein
YP_001291194.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_001291195.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_001291196.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_001291197.1	COG0500 SAM-dependent methyltransferases
YP_001291199.1	COG0475 Kef-type K+ transport systems, membrane components
YP_001291200.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_001291201.1	COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase)
YP_001291202.1	COG4701 Uncharacterized protein conserved in bacteria
YP_001291203.1	COG0590 Cytosine/adenosine deaminases
YP_001291204.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_001291205.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_001291206.1	COG0730 Predicted permeases
YP_001291207.1	hydrolyzes diadenosine polyphosphate
YP_001291208.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_001291209.1	COG0262 Dihydrofolate reductase
YP_001291210.1	COG1566 Multidrug resistance efflux pump
YP_001291211.1	COG3087 Cell division protein
YP_001291212.1	COG0841 Cation/multidrug efflux pump
YP_001291213.1	COG0845 Membrane-fusion protein
YP_001291215.1	enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation
YP_001291216.1	COG3024 Uncharacterized protein conserved in bacteria
YP_001291217.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_001291218.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_001291219.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001291220.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_001291221.1	involved in de novo purine biosynthesis
YP_001291222.1	COG2259 Predicted membrane protein
YP_001291223.1	two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_001291224.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_001291225.1	COG1115 Na+/alanine symporter
YP_001291226.1	COG1636 Uncharacterized protein conserved in bacteria
YP_001291227.1	COG0142 Geranylgeranyl pyrophosphate synthase
YP_001291228.1	COG0261 Ribosomal protein L21
YP_001291229.1	involved in the peptidyltransferase reaction during translation
YP_001291230.1	COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily
YP_001291231.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_001291232.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_001291233.1	catalyzes the removal of an N-terminal amino acid from a peptide or arylamide
YP_001291234.1	COG3307 Lipid A core - O-antigen ligase and related enzymes
YP_001291235.1	COG1088 dTDP-D-glucose 4,6-dehydratase
YP_001291237.1	COG2148 Sugar transferases involved in lipopolysaccharide synthesis
YP_001291239.1	COG3307 Lipid A core - O-antigen ligase and related enzymes
YP_001291240.1	COG1216 Predicted glycosyltransferases
YP_001291241.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001291242.1	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
YP_001291243.1	COG0174 Glutamine synthetase
YP_001291244.1	COG1217 Predicted membrane GTPase involved in stress response
YP_001291245.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_001291246.1	COG1738 Uncharacterized conserved protein
YP_001291247.1	COG0557 Exoribonuclease R
YP_001291248.1	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
YP_001291249.1	COG0542 ATPases with chaperone activity, ATP-binding subunit
YP_001291250.1	COG0212 5-formyltetrahydrofolate cyclo-ligase
YP_001291251.1	COG3027 Uncharacterized protein conserved in bacteria
YP_001291252.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_001291253.1	COG3681 Uncharacterized conserved protein
YP_001291254.1	COG0748 Putative heme iron utilization protein
YP_001291255.1	COG0747 ABC-type dipeptide transport system, periplasmic component
YP_001291258.1	COG3086 Positive regulator of sigma E activity
YP_001291259.1	COG0500 SAM-dependent methyltransferases
YP_001291260.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_001291261.1	COG3085 Uncharacterized protein conserved in bacteria
YP_001291262.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_001291263.1	COG3084 Uncharacterized protein conserved in bacteria
YP_001291264.1	in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis
YP_001291265.1	COG0402 Cytosine deaminase and related metal-dependent hydrolases
YP_001291266.1	COG3082 Uncharacterized protein conserved in bacteria
YP_001291267.1	COG3081 Nucleoid-associated protein
YP_001291268.1	COG2913 Small protein A (tmRNA-binding)
YP_001291269.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_001291270.1	COG0642 Signal transduction histidine kinase
YP_001291271.1	COG0642 Signal transduction histidine kinase
YP_001291272.1	lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001291273.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_001291274.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_001291275.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_001291276.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_001291277.1	glycosyltransferase; polymerizes glycan strands in the peptidoglycan
YP_001291278.1	When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription
YP_001291279.1	COG1196 Chromosome segregation ATPases
YP_001291280.1	unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity
YP_001291281.1	COG1607 Acyl-CoA hydrolase
YP_001291282.1	Involved in cell division; probably involved in intracellular septation
YP_001291283.1	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
YP_001291284.1	ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex
YP_001291285.1	with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains
YP_001291286.1	COG1879 ABC-type sugar transport system, periplasmic component
YP_001291287.1	COG1609 Transcriptional regulators
YP_001291288.1	catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P
YP_001291289.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_001291290.1	catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose
YP_001291291.1	the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown
YP_001291292.1	COG0006 Xaa-Pro aminopeptidase
YP_001291293.1	COG0589 Universal stress protein UspA and related nucleotide-binding proteins
YP_001291294.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001291295.1	affects carbohydrate metabolism; has regulatory role in many processes
YP_001291296.1	COG1210 UDP-glucose pyrophosphorylase
YP_001291297.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_001291298.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_001291299.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_001291300.1	COG0233 Ribosome recycling factor
YP_001291301.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_001291302.1	COG0730 Predicted permeases
YP_001291303.1	COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)
YP_001291304.1	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
YP_001291305.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_001291306.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_001291307.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_001291308.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_001291309.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_001291310.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_001291311.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_001291312.1	late assembly protein
YP_001291313.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_001291314.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_001291315.1	binds 5S rRNA along with protein L5 and L25
YP_001291316.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_001291317.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_001291318.1	COG0199 Ribosomal protein S14
YP_001291319.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_001291320.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_001291321.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_001291322.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_001291323.1	one of the stabilizing components for the large ribosomal subunit
YP_001291324.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_001291325.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_001291326.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_001291327.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_001291328.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_001291329.1	COG0089 Ribosomal protein L23
YP_001291330.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_001291331.1	COG0051 Ribosomal protein S10
YP_001291332.1	COG1070 Sugar (pentulose and hexulose) kinases
YP_001291333.1	COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain
YP_001291334.1	COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components
YP_001291335.1	COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components
YP_001291336.1	COG1879 ABC-type sugar transport system, periplasmic component
YP_001291337.1	COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes
YP_001291338.1	COG1359 Uncharacterized conserved protein
YP_001291339.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_001291340.1	putative ABC transporter, membrane protein
YP_001291341.1	COG2884 Predicted ATPase involved in cell division
YP_001291342.1	COG0552 Signal recognition particle GTPase
YP_001291343.1	COG0742 N6-adenine-specific methylase
YP_001291344.1	COG0219 Predicted rRNA methylase (SpoU class)
YP_001291345.1	COG3306 Glycosyltransferase involved in LPS biosynthesis
YP_001291346.1	DHBP synthase; functions during riboflavin biosynthesis
YP_001291347.1	COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases
YP_001291348.1	Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_001291349.1	COG2924 Fe-S cluster protector protein
YP_001291350.1	COG1194 A/G-specific DNA glycosylase
YP_001291351.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_001291352.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_001291353.1	COG2861 Uncharacterized protein conserved in bacteria
YP_001291355.1	COG3306 Glycosyltransferase involved in LPS biosynthesis
YP_001291356.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_001291357.1	COG3477 Predicted periplasmic/secreted protein
YP_001291358.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_001291359.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_001291360.1	Represses a number of genes involved in the response to DNA damage
YP_001291361.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_001291362.1	COG1252 NADH dehydrogenase, FAD-containing subunit
YP_001291363.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_001291364.1	catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis
YP_001291365.1	COG0607 Rhodanese-related sulfurtransferase
YP_001291366.1	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_001291369.1	COG1109 Phosphomannomutase
YP_001291370.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_001291371.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_001291372.1	COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
YP_001291374.1	COG0733 Na+-dependent transporters of the SNF family
YP_001291375.1	catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine
YP_001291376.1	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase
YP_001291377.1	COG2132 Putative multicopper oxidases
YP_001291378.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_001291379.1	COG0514 Superfamily II DNA helicase
YP_001291380.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_001291381.1	COG5567 Predicted small periplasmic lipoprotein
YP_001291382.1	COG0019 Diaminopimelate decarboxylase
YP_001291384.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
YP_001291385.1	COG3078 Uncharacterized protein conserved in bacteria
YP_001291386.1	COG0168 Trk-type K+ transport systems, membrane components
YP_001291387.1	COG1739 Uncharacterized conserved protein
YP_001291388.1	TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs
YP_001291389.1	putative metalloprotease
YP_001291390.1	COG0251 Putative translation initiation inhibitor, yjgF family
YP_001291391.1	COG2853 Surface lipoprotein
YP_001291392.1	Modulates Rho-dependent transcription termination
YP_001291393.1	forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_001291394.1	binds and unfolds substrates as part of the ClpXP protease
YP_001291395.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_001291396.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_001291397.1	COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)
YP_001291398.1	COG3041 Uncharacterized protein conserved in bacteria
YP_001291400.1	COG3077 DNA-damage-inducible protein J
YP_001291401.1	COG3276 Selenocysteine-specific translation elongation factor
YP_001291402.1	catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis
YP_001291403.1	COG1672 Predicted ATPase (AAA+ superfamily)
YP_001291404.1	This protein performs the mismatch recognition step during the DNA repair process
YP_001291405.1	COG0739 Membrane proteins related to metalloendopeptidases
YP_001291406.1	COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases
YP_001291407.1	COG1238 Predicted membrane protein
YP_001291408.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_001291409.1	catalyzes the modification of U13 in tRNA(Glu)
YP_001291410.1	COG3076 Uncharacterized protein conserved in bacteria
YP_001291411.1	COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2
YP_001291412.1	COG0729 Outer membrane protein
YP_001291413.1	COG2911 Uncharacterized protein conserved in bacteria
YP_001291414.1	COG0248 Exopolyphosphatase
YP_001291415.1	COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases
YP_001291416.1	COG2503 Predicted secreted acid phosphatase
YP_001291417.1	COG0584 Glycerophosphoryl diester phosphodiesterase
YP_001291418.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_001291419.1	COG0059 Ketol-acid reductoisomerase
YP_001291420.1	participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate
YP_001291421.1	COG2962 Predicted permeases
YP_001291422.1	COG0607 Rhodanese-related sulfurtransferase
YP_001291423.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_001291424.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_001291425.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_001291426.1	COG2195 Di- and tripeptidases
YP_001291427.1	catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively
YP_001291428.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_001291429.1	hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic
YP_001291430.1	COG2271 Sugar phosphate permease
YP_001291431.1	anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor
YP_001291432.1	sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters
YP_001291433.1	anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate
YP_001291434.1	COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components
YP_001291436.1	COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component
YP_001291437.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome
YP_001291438.1	COG1629 Outer membrane receptor proteins, mostly Fe transport
YP_001291439.1	COG2801 Transposase and inactivated derivatives
YP_001291440.1	catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively
YP_001291442.1	forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein
YP_001291443.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_001291444.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_001291445.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_001291446.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_001291447.1	COG3074 Uncharacterized protein conserved in bacteria
YP_001291448.1	COG1396 Predicted transcriptional regulators
YP_001291449.1	COG3550 Uncharacterized protein related to capsule biosynthesis enzymes
YP_001291450.1	COG3550 Uncharacterized protein related to capsule biosynthesis enzymes
YP_001291451.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_001291455.1	COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components
YP_001291456.1	COG1629 Outer membrane receptor proteins, mostly Fe transport
YP_001291457.1	COG4679 Phage-related protein
YP_001291458.1	COG1396 Predicted transcriptional regulators
YP_001291459.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_001291460.1	COG0551 Zn-finger domain associated with topoisomerase type I
YP_001291461.1	COG0009 Putative translation factor (SUA5)
YP_001291462.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_001291463.1	COG0169 Shikimate 5-dehydrogenase
YP_001291464.1	COG2818 3-methyladenine DNA glycosylase
YP_001291465.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_001291466.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_001291467.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_001291468.1	COG0669 Phosphopantetheine adenylyltransferase
YP_001291469.1	COG0210 Superfamily I DNA and RNA helicases
YP_001291470.1	COG0583 Transcriptional regulator
YP_001291472.1	COG2249 Putative NADPH-quinone reductase (modulator of drug activity B)
YP_001291473.1	COG1285 Uncharacterized membrane protein
YP_001291474.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_001291475.1	COG2267 Lysophospholipase
YP_001291476.1	COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit
YP_001291477.1	COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
YP_001291478.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_001291479.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_001291480.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_001291481.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_001291482.1	HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis
YP_001291483.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001291484.1	COG3691 Uncharacterized protein conserved in bacteria
YP_001291485.1	COG0042 tRNA-dihydrouridine synthase
YP_001291486.1	COG0038 Chloride channel protein EriC
YP_001291487.1	COG0038 Chloride channel protein EriC
YP_001291488.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_001291489.1	COG0050 GTPases - translation elongation factors
YP_001291490.1	periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP
YP_001291491.1	COG3073 Negative regulator of sigma E activity
YP_001291492.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_001291493.1	COG2938 Uncharacterized conserved protein
YP_001291494.1	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_001291495.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_001291496.1	COG0144 tRNA and rRNA cytosine-C5-methylases
YP_001291497.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_001291498.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_001291503.1	COG0242 N-formylmethionyl-tRNA deformylase
YP_001291504.1	COG3070 Regulator of competence-specific genes
YP_001291505.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_001291506.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_001291507.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_001291508.1	reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_001291509.1	COG1288 Predicted membrane protein