-- dump date   	20140619_104341
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
374930000001	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
374930000002	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930000003	potential frameshift: common BLAST hit: gi|68249200|ref|YP_248312.1| peptidase E [Haemophilus influenzae 86-028NP]
374930000004	potential frameshift: common BLAST hit: gi|68249201|ref|YP_248313.1| predicted C4-dicarboxylate transporter [Haemophilus influenzae]
374930000005	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
374930000006	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
374930000007	putative metal binding site [ion binding]; other site
374930000008	dimer interface [polypeptide binding]; other site
374930000009	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
374930000010	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
374930000011	active site
374930000012	metal binding site [ion binding]; metal-binding site
374930000013	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
374930000014	Methyltransferase domain; Region: Methyltransf_24; pfam13578
374930000015	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
374930000016	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
374930000017	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
374930000018	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
374930000019	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
374930000020	S17 interaction site [polypeptide binding]; other site
374930000021	S8 interaction site; other site
374930000022	16S rRNA interaction site [nucleotide binding]; other site
374930000023	streptomycin interaction site [chemical binding]; other site
374930000024	23S rRNA interaction site [nucleotide binding]; other site
374930000025	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
374930000026	30S ribosomal protein S7; Validated; Region: PRK05302
374930000027	elongation factor G; Reviewed; Region: PRK00007
374930000028	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
374930000029	G1 box; other site
374930000030	putative GEF interaction site [polypeptide binding]; other site
374930000031	GTP/Mg2+ binding site [chemical binding]; other site
374930000032	Switch I region; other site
374930000033	G2 box; other site
374930000034	G3 box; other site
374930000035	Switch II region; other site
374930000036	G4 box; other site
374930000037	G5 box; other site
374930000038	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
374930000039	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
374930000040	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
374930000041	elongation factor Tu; Reviewed; Region: PRK00049
374930000042	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
374930000043	G1 box; other site
374930000044	GEF interaction site [polypeptide binding]; other site
374930000045	GTP/Mg2+ binding site [chemical binding]; other site
374930000046	Switch I region; other site
374930000047	G2 box; other site
374930000048	G3 box; other site
374930000049	Switch II region; other site
374930000050	G4 box; other site
374930000051	G5 box; other site
374930000052	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
374930000053	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
374930000054	Antibiotic Binding Site [chemical binding]; other site
374930000055	Uncharacterized conserved protein involved in oxidation of intracellular sulfur [Inorganic ion transport and metabolism]; Region: DsrH; COG2168
374930000056	sulfur relay protein TusC; Validated; Region: PRK00211
374930000057	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
374930000058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
374930000059	YheO-like PAS domain; Region: PAS_6; pfam08348
374930000060	HTH domain; Region: HTH_22; pfam13309
374930000061	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
374930000062	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
374930000063	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
374930000064	hypothetical protein; Provisional; Region: PRK02119
374930000065	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
374930000066	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
374930000067	catalytic triad [active]
374930000068	dimer interface [polypeptide binding]; other site
374930000069	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
374930000070	GSH binding site [chemical binding]; other site
374930000071	catalytic residues [active]
374930000072	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
374930000073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
374930000074	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
374930000075	dimerization interface [polypeptide binding]; other site
374930000076	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
374930000077	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
374930000078	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
374930000079	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
374930000080	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
374930000081	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
374930000082	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
374930000083	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
374930000084	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
374930000085	RNA binding site [nucleotide binding]; other site
374930000086	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
374930000087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930000088	ATP binding site [chemical binding]; other site
374930000089	Mg2+ binding site [ion binding]; other site
374930000090	G-X-G motif; other site
374930000091	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
374930000092	anchoring element; other site
374930000093	dimer interface [polypeptide binding]; other site
374930000094	ATP binding site [chemical binding]; other site
374930000095	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
374930000096	active site
374930000097	putative metal-binding site [ion binding]; other site
374930000098	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
374930000099	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
374930000100	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
374930000101	substrate binding site [chemical binding]; other site
374930000102	hexamer interface [polypeptide binding]; other site
374930000103	metal binding site [ion binding]; metal-binding site
374930000104	phosphoglycolate phosphatase; Provisional; Region: PRK13222
374930000105	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
374930000106	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
374930000107	motif II; other site
374930000108	Helix-turn-helix domain; Region: HTH_28; pfam13518
374930000109	Integrase core domain; Region: rve; pfam00665
374930000110	Integrase core domain; Region: rve_2; pfam13333
374930000111	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
374930000112	dimer interface [polypeptide binding]; other site
374930000113	active site
374930000114	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
374930000115	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
374930000116	dimerization interface [polypeptide binding]; other site
374930000117	putative DNA binding site [nucleotide binding]; other site
374930000118	putative Zn2+ binding site [ion binding]; other site
374930000119	AsnC family; Region: AsnC_trans_reg; pfam01037
374930000120	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930000121	RNA binding surface [nucleotide binding]; other site
374930000122	Predicted membrane protein [Function unknown]; Region: COG1297
374930000123	putative oligopeptide transporter, OPT family; Region: TIGR00733
374930000124	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
374930000125	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
374930000126	active site
374930000127	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
374930000128	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
374930000129	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
374930000130	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
374930000131	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
374930000132	putative active site [active]
374930000133	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
374930000134	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
374930000135	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
374930000136	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
374930000137	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786
374930000138	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
374930000139	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
374930000140	active site
374930000141	metal binding site [ion binding]; metal-binding site
374930000142	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930000143	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
374930000144	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
374930000145	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
374930000146	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
374930000147	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
374930000148	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930000149	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
374930000150	rRNA binding site [nucleotide binding]; other site
374930000151	predicted 30S ribosome binding site; other site
374930000152	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
374930000153	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
374930000154	dimer interface [polypeptide binding]; other site
374930000155	ssDNA binding site [nucleotide binding]; other site
374930000156	tetramer (dimer of dimers) interface [polypeptide binding]; other site
374930000157	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
374930000158	ribosomal protein L9; Region: L9; TIGR00158
374930000159	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
374930000160	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
374930000161	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
374930000162	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
374930000163	ring oligomerisation interface [polypeptide binding]; other site
374930000164	ATP/Mg binding site [chemical binding]; other site
374930000165	stacking interactions; other site
374930000166	hinge regions; other site
374930000167	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
374930000168	oligomerisation interface [polypeptide binding]; other site
374930000169	mobile loop; other site
374930000170	roof hairpin; other site
374930000171	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
374930000172	alpha-gamma subunit interface [polypeptide binding]; other site
374930000173	beta-gamma subunit interface [polypeptide binding]; other site
374930000174	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
374930000175	gamma-beta subunit interface [polypeptide binding]; other site
374930000176	alpha-beta subunit interface [polypeptide binding]; other site
374930000177	urease subunit alpha; Reviewed; Region: ureC; PRK13207
374930000178	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
374930000179	subunit interactions [polypeptide binding]; other site
374930000180	active site
374930000181	flap region; other site
374930000182	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
374930000183	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
374930000184	dimer interface [polypeptide binding]; other site
374930000185	catalytic residues [active]
374930000186	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
374930000187	UreF; Region: UreF; pfam01730
374930000188	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
374930000189	G1 box; other site
374930000190	GTP/Mg2+ binding site [chemical binding]; other site
374930000191	G2 box; other site
374930000192	Switch I region; other site
374930000193	G3 box; other site
374930000194	Switch II region; other site
374930000195	G4 box; other site
374930000196	G5 box; other site
374930000197	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
374930000198	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
374930000199	Aspartase; Region: Aspartase; cd01357
374930000200	active sites [active]
374930000201	tetramer interface [polypeptide binding]; other site
374930000202	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
374930000203	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
374930000204	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
374930000205	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
374930000206	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
374930000207	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
374930000208	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
374930000209	DNA binding residues [nucleotide binding]
374930000210	DNA primase; Validated; Region: dnaG; PRK05667
374930000211	CHC2 zinc finger; Region: zf-CHC2; pfam01807
374930000212	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
374930000213	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
374930000214	active site
374930000215	metal binding site [ion binding]; metal-binding site
374930000216	interdomain interaction site; other site
374930000217	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
374930000218	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
374930000219	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
374930000220	UGMP family protein; Validated; Region: PRK09604
374930000221	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
374930000222	thymidine kinase; Provisional; Region: PRK04296
374930000223	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
374930000224	ATP binding site [chemical binding]; other site
374930000225	Walker A motif; other site
374930000226	Walker B motif; other site
374930000227	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
374930000228	aromatic amino acid transport protein; Region: araaP; TIGR00837
374930000229	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
374930000230	Ribonuclease I [Translation, ribosomal structure and biogenesis]; Region: Rna; COG3719
374930000231	CAS motifs; other site
374930000232	active site
374930000233	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
374930000234	Phosphoglycerate kinase; Region: PGK; pfam00162
374930000235	substrate binding site [chemical binding]; other site
374930000236	hinge regions; other site
374930000237	ADP binding site [chemical binding]; other site
374930000238	catalytic site [active]
374930000239	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
374930000240	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
374930000241	active site
374930000242	intersubunit interface [polypeptide binding]; other site
374930000243	zinc binding site [ion binding]; other site
374930000244	Na+ binding site [ion binding]; other site
374930000245	potential frameshift: common BLAST hit: gi|68249120|ref|YP_248232.1| ADP-heptose--lipooligosaccharide heptosyltransferase III
374930000246	potential frameshift: common BLAST hit: gi|68249119|ref|YP_248231.1| predicted membrane protein [Haemophilus influenzae 86-028NP]
374930000247	glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040
374930000248	Pyruvate formate lyase; Region: PFL; pfam02901
374930000249	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
374930000250	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930000251	FeS/SAM binding site; other site
374930000252	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
374930000253	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
374930000254	Nucleoside recognition; Region: Gate; pfam07670
374930000255	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
374930000256	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
374930000257	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
374930000258	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
374930000259	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
374930000260	23S rRNA interface [nucleotide binding]; other site
374930000261	L7/L12 interface [polypeptide binding]; other site
374930000262	putative thiostrepton binding site; other site
374930000263	L25 interface [polypeptide binding]; other site
374930000264	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
374930000265	mRNA/rRNA interface [nucleotide binding]; other site
374930000266	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
374930000267	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
374930000268	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
374930000269	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
374930000270	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
374930000271	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
374930000272	RPB1 interaction site [polypeptide binding]; other site
374930000273	RPB11 interaction site [polypeptide binding]; other site
374930000274	RPB10 interaction site [polypeptide binding]; other site
374930000275	RPB3 interaction site [polypeptide binding]; other site
374930000276	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
374930000277	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
374930000278	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
374930000279	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
374930000280	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
374930000281	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
374930000282	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
374930000283	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
374930000284	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
374930000285	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
374930000286	DNA binding site [nucleotide binding]
374930000287	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
374930000288	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
374930000289	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
374930000290	gating phenylalanine in ion channel; other site
374930000291	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
374930000292	homodimer interaction site [polypeptide binding]; other site
374930000293	cofactor binding site; other site
374930000294	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
374930000295	UbiA prenyltransferase family; Region: UbiA; pfam01040
374930000296	regulator of ribonuclease activity A; Region: RraA_entero; TIGR02998
374930000297	hypothetical protein; Provisional; Region: PRK05208
374930000298	transcriptional repressor RbsR; Provisional; Region: PRK10423
374930000299	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
374930000300	DNA binding site [nucleotide binding]
374930000301	domain linker motif; other site
374930000302	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
374930000303	dimerization interface [polypeptide binding]; other site
374930000304	ligand binding site [chemical binding]; other site
374930000305	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
374930000306	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
374930000307	substrate binding site [chemical binding]; other site
374930000308	dimer interface [polypeptide binding]; other site
374930000309	ATP binding site [chemical binding]; other site
374930000310	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
374930000311	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
374930000312	ligand binding site [chemical binding]; other site
374930000313	dimerization interface [polypeptide binding]; other site
374930000314	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
374930000315	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930000316	TM-ABC transporter signature motif; other site
374930000317	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
374930000318	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
374930000319	Walker A/P-loop; other site
374930000320	ATP binding site [chemical binding]; other site
374930000321	Q-loop/lid; other site
374930000322	ABC transporter signature motif; other site
374930000323	Walker B; other site
374930000324	D-loop; other site
374930000325	H-loop/switch region; other site
374930000326	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
374930000327	D-ribose pyranase; Provisional; Region: PRK11797
374930000328	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
374930000329	RmuC family; Region: RmuC; pfam02646
374930000330	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
374930000331	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
374930000332	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
374930000333	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
374930000334	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
374930000335	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
374930000336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930000337	Walker A motif; other site
374930000338	ATP binding site [chemical binding]; other site
374930000339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930000340	Walker B motif; other site
374930000341	arginine finger; other site
374930000342	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
374930000343	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
374930000344	HslU subunit interaction site [polypeptide binding]; other site
374930000345	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
374930000346	Integrase core domain; Region: rve; pfam00665
374930000347	Integrase core domain; Region: rve_3; cl15866
374930000348	S-ribosylhomocysteinase; Provisional; Region: PRK02260
374930000349	Predicted membrane protein [Function unknown]; Region: COG1238
374930000350	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
374930000351	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
374930000352	motif II; other site
374930000353	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
374930000354	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
374930000355	F0F1 ATP synthase subunit I; Validated; Region: PRK06099
374930000356	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
374930000357	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
374930000358	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
374930000359	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
374930000360	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
374930000361	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
374930000362	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
374930000363	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
374930000364	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
374930000365	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
374930000366	beta subunit interaction interface [polypeptide binding]; other site
374930000367	Walker A motif; other site
374930000368	ATP binding site [chemical binding]; other site
374930000369	Walker B motif; other site
374930000370	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
374930000371	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
374930000372	core domain interface [polypeptide binding]; other site
374930000373	delta subunit interface [polypeptide binding]; other site
374930000374	epsilon subunit interface [polypeptide binding]; other site
374930000375	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
374930000376	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
374930000377	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
374930000378	alpha subunit interaction interface [polypeptide binding]; other site
374930000379	Walker A motif; other site
374930000380	ATP binding site [chemical binding]; other site
374930000381	Walker B motif; other site
374930000382	inhibitor binding site; inhibition site
374930000383	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
374930000384	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
374930000385	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
374930000386	gamma subunit interface [polypeptide binding]; other site
374930000387	epsilon subunit interface [polypeptide binding]; other site
374930000388	LBP interface [polypeptide binding]; other site
374930000389	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
374930000390	aromatic amino acid transport protein; Region: araaP; TIGR00837
374930000391	potential frameshift: common BLAST hit: gi|68249077|ref|YP_248189.1| histidine biosynthesis bifunctional protein HisIE [Haemophilus]
374930000392	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
374930000393	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
374930000394	substrate binding site [chemical binding]; other site
374930000395	glutamase interaction surface [polypeptide binding]; other site
374930000396	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
374930000397	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
374930000398	catalytic residues [active]
374930000399	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
374930000400	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
374930000401	putative active site [active]
374930000402	oxyanion strand; other site
374930000403	catalytic triad [active]
374930000404	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
374930000405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
374930000406	active site
374930000407	motif I; other site
374930000408	motif II; other site
374930000409	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
374930000410	putative active site pocket [active]
374930000411	4-fold oligomerization interface [polypeptide binding]; other site
374930000412	metal binding residues [ion binding]; metal-binding site
374930000413	3-fold/trimer interface [polypeptide binding]; other site
374930000414	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
374930000415	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
374930000416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930000417	homodimer interface [polypeptide binding]; other site
374930000418	catalytic residue [active]
374930000419	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
374930000420	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
374930000421	NAD binding site [chemical binding]; other site
374930000422	dimerization interface [polypeptide binding]; other site
374930000423	product binding site; other site
374930000424	substrate binding site [chemical binding]; other site
374930000425	zinc binding site [ion binding]; other site
374930000426	catalytic residues [active]
374930000427	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
374930000428	ATP phosphoribosyltransferase; Region: HisG; pfam01634
374930000429	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
374930000430	hypothetical protein; Provisional; Region: PRK11820
374930000431	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
374930000432	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
374930000433	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
374930000434	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
374930000435	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
374930000436	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
374930000437	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
374930000438	ligand binding site [chemical binding]; other site
374930000439	NAD binding site [chemical binding]; other site
374930000440	tetramer interface [polypeptide binding]; other site
374930000441	catalytic site [active]
374930000442	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
374930000443	L-serine binding site [chemical binding]; other site
374930000444	ACT domain interface; other site
374930000445	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
374930000446	tetramer (dimer of dimers) interface [polypeptide binding]; other site
374930000447	active site
374930000448	dimer interface [polypeptide binding]; other site
374930000449	HemN family oxidoreductase; Provisional; Region: PRK05660
374930000450	HemN C-terminal domain; Region: HemN_C; pfam06969
374930000451	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
374930000452	Found in ATP-dependent protease La (LON); Region: LON; smart00464
374930000453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930000454	Walker A motif; other site
374930000455	ATP binding site [chemical binding]; other site
374930000456	Walker B motif; other site
374930000457	arginine finger; other site
374930000458	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
374930000459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
374930000460	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
374930000461	homodimer interface [polypeptide binding]; other site
374930000462	MazG family protein; Region: mazG; TIGR00444
374930000463	metal binding site [ion binding]; metal-binding site
374930000464	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
374930000465	homodimer interface [polypeptide binding]; other site
374930000466	active site
374930000467	putative chemical substrate binding site [chemical binding]; other site
374930000468	metal binding site [ion binding]; metal-binding site
374930000469	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
374930000470	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930000471	active site
374930000472	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
374930000473	SurA N-terminal domain; Region: SurA_N; pfam09312
374930000474	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
374930000475	conserved hypothetical protein, YceG family; Region: TIGR00247
374930000476	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
374930000477	dimerization interface [polypeptide binding]; other site
374930000478	thymidylate kinase; Validated; Region: tmk; PRK00698
374930000479	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
374930000480	TMP-binding site; other site
374930000481	ATP-binding site [chemical binding]; other site
374930000482	DNA polymerase III subunit delta'; Validated; Region: PRK06871
374930000483	DNA polymerase III subunit delta'; Validated; Region: PRK08485
374930000484	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
374930000485	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
374930000486	active site
374930000487	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
374930000488	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
374930000489	Domain of unknown function DUF21; Region: DUF21; pfam01595
374930000490	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
374930000491	Transporter associated domain; Region: CorC_HlyC; smart01091
374930000492	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
374930000493	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779
374930000494	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
374930000495	active site
374930000496	phosphorylation site [posttranslational modification]
374930000497	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
374930000498	dimerization domain swap beta strand [polypeptide binding]; other site
374930000499	regulatory protein interface [polypeptide binding]; other site
374930000500	active site
374930000501	regulatory phosphorylation site [posttranslational modification]; other site
374930000502	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
374930000503	dimerization domain swap beta strand [polypeptide binding]; other site
374930000504	regulatory protein interface [polypeptide binding]; other site
374930000505	active site
374930000506	regulatory phosphorylation site [posttranslational modification]; other site
374930000507	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
374930000508	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
374930000509	putative substrate binding site [chemical binding]; other site
374930000510	putative ATP binding site [chemical binding]; other site
374930000511	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
374930000512	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
374930000513	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
374930000514	active site
374930000515	P-loop; other site
374930000516	phosphorylation site [posttranslational modification]
374930000517	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
374930000518	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
374930000519	DNA topoisomerase III; Provisional; Region: PRK07726
374930000520	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
374930000521	active site
374930000522	putative interdomain interaction site [polypeptide binding]; other site
374930000523	putative metal-binding site [ion binding]; other site
374930000524	putative nucleotide binding site [chemical binding]; other site
374930000525	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
374930000526	domain I; other site
374930000527	DNA binding groove [nucleotide binding]
374930000528	phosphate binding site [ion binding]; other site
374930000529	domain II; other site
374930000530	domain III; other site
374930000531	nucleotide binding site [chemical binding]; other site
374930000532	catalytic site [active]
374930000533	domain IV; other site
374930000534	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353
374930000535	RecR protein; Region: RecR; pfam02132
374930000536	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
374930000537	putative active site [active]
374930000538	putative metal-binding site [ion binding]; other site
374930000539	tetramer interface [polypeptide binding]; other site
374930000540	hypothetical protein; Validated; Region: PRK00153
374930000541	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
374930000542	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
374930000543	Transglycosylase; Region: Transgly; pfam00912
374930000544	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
374930000545	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
374930000546	Pilus assembly protein, PilP; Region: PilP; pfam04351
374930000547	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
374930000548	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
374930000549	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
374930000550	comF family protein; Region: comF; TIGR00201
374930000551	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930000552	active site
374930000553	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
374930000554	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
374930000555	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
374930000556	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
374930000557	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
374930000558	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
374930000559	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
374930000560	putative NADH binding site [chemical binding]; other site
374930000561	putative active site [active]
374930000562	nudix motif; other site
374930000563	putative metal binding site [ion binding]; other site
374930000564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
374930000565	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
374930000566	IHF dimer interface [polypeptide binding]; other site
374930000567	IHF - DNA interface [nucleotide binding]; other site
374930000568	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
374930000569	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
374930000570	glutaminase active site [active]
374930000571	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
374930000572	dimer interface [polypeptide binding]; other site
374930000573	active site
374930000574	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
374930000575	dimer interface [polypeptide binding]; other site
374930000576	active site
374930000577	disulfide bond formation protein B; Provisional; Region: PRK01749
374930000578	potential frameshift: common BLAST hit: gi|30995374|ref|NP_438588.2| Na+/H+ antiporter [Haemophilus influenzae Rd KW20]
374930000579	fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812
374930000580	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
374930000581	DNA-binding site [nucleotide binding]; DNA binding site
374930000582	FadR C-terminal domain; Region: FadR_C; pfam07840
374930000583	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
374930000584	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
374930000585	domain interface [polypeptide binding]; other site
374930000586	putative active site [active]
374930000587	catalytic site [active]
374930000588	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
374930000589	domain interface [polypeptide binding]; other site
374930000590	putative active site [active]
374930000591	catalytic site [active]
374930000592	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
374930000593	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
374930000594	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
374930000595	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
374930000596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930000597	S-adenosylmethionine binding site [chemical binding]; other site
374930000598	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
374930000599	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
374930000600	ATP binding site [chemical binding]; other site
374930000601	Mg++ binding site [ion binding]; other site
374930000602	motif III; other site
374930000603	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930000604	nucleotide binding region [chemical binding]; other site
374930000605	ATP-binding site [chemical binding]; other site
374930000606	putative protease; Provisional; Region: PRK15452
374930000607	Peptidase family U32; Region: Peptidase_U32; pfam01136
374930000608	metabolite-proton symporter; Region: 2A0106; TIGR00883
374930000609	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930000610	putative substrate translocation pore; other site
374930000611	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
374930000612	thiamine phosphate binding site [chemical binding]; other site
374930000613	active site
374930000614	pyrophosphate binding site [ion binding]; other site
374930000615	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
374930000616	dimer interface [polypeptide binding]; other site
374930000617	substrate binding site [chemical binding]; other site
374930000618	ATP binding site [chemical binding]; other site
374930000619	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
374930000620	substrate binding site [chemical binding]; other site
374930000621	multimerization interface [polypeptide binding]; other site
374930000622	ATP binding site [chemical binding]; other site
374930000623	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
374930000624	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
374930000625	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
374930000626	homodimer interface [polypeptide binding]; other site
374930000627	oligonucleotide binding site [chemical binding]; other site
374930000628	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
374930000629	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
374930000630	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930000631	RNA binding surface [nucleotide binding]; other site
374930000632	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
374930000633	active site
374930000634	bacterial Hfq-like; Region: Hfq; cd01716
374930000635	hexamer interface [polypeptide binding]; other site
374930000636	Sm1 motif; other site
374930000637	RNA binding site [nucleotide binding]; other site
374930000638	Sm2 motif; other site
374930000639	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
374930000640	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930000641	Walker A motif; other site
374930000642	ATP binding site [chemical binding]; other site
374930000643	Walker B motif; other site
374930000644	arginine finger; other site
374930000645	putative peptidase; Provisional; Region: PRK11649
374930000646	Peptidase family M23; Region: Peptidase_M23; pfam01551
374930000647	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
374930000648	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930000649	Walker A/P-loop; other site
374930000650	ATP binding site [chemical binding]; other site
374930000651	Q-loop/lid; other site
374930000652	ABC transporter signature motif; other site
374930000653	Walker B; other site
374930000654	D-loop; other site
374930000655	H-loop/switch region; other site
374930000656	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
374930000657	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
374930000658	ABC-ATPase subunit  interface; other site
374930000659	dimer interface [polypeptide binding]; other site
374930000660	putative PBP binding regions; other site
374930000661	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
374930000662	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
374930000663	pyridoxamine kinase; Validated; Region: PRK05756
374930000664	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
374930000665	dimer interface [polypeptide binding]; other site
374930000666	pyridoxal binding site [chemical binding]; other site
374930000667	ATP binding site [chemical binding]; other site
374930000668	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
374930000669	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
374930000670	Ligand Binding Site [chemical binding]; other site
374930000671	TilS substrate binding domain; Region: TilS; pfam09179
374930000672	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
374930000673	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
374930000674	putative DNA-binding cleft [nucleotide binding]; other site
374930000675	putative DNA clevage site; other site
374930000676	molecular lever; other site
374930000677	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
374930000678	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
374930000679	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
374930000680	DNA binding site [nucleotide binding]
374930000681	active site
374930000682	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
374930000683	conserved hypothetical protein; Region: TIGR00743
374930000684	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
374930000685	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
374930000686	active site
374930000687	metal binding site [ion binding]; metal-binding site
374930000688	hexamer interface [polypeptide binding]; other site
374930000689	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
374930000690	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
374930000691	dimer interface [polypeptide binding]; other site
374930000692	ADP-ribose binding site [chemical binding]; other site
374930000693	active site
374930000694	nudix motif; other site
374930000695	metal binding site [ion binding]; metal-binding site
374930000696	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
374930000697	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
374930000698	generic binding surface II; other site
374930000699	generic binding surface I; other site
374930000700	Uncharacterized conserved protein [Function unknown]; Region: COG2850
374930000701	hypothetical protein; Validated; Region: PRK01777
374930000702	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
374930000703	putative active site [active]
374930000704	GTP-binding protein YchF; Reviewed; Region: PRK09601
374930000705	YchF GTPase; Region: YchF; cd01900
374930000706	G1 box; other site
374930000707	GTP/Mg2+ binding site [chemical binding]; other site
374930000708	Switch I region; other site
374930000709	G2 box; other site
374930000710	Switch II region; other site
374930000711	G3 box; other site
374930000712	G4 box; other site
374930000713	G5 box; other site
374930000714	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
374930000715	potential frameshift: common BLAST hit: gi|59802031|ref|YP_208743.1| putative trans-acylase protein [Neisseria gonorrhoeae FA 1090]
374930000716	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
374930000717	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
374930000718	catalytic site [active]
374930000719	putative active site [active]
374930000720	putative substrate binding site [chemical binding]; other site
374930000721	Helicase and RNase D C-terminal; Region: HRDC; smart00341
374930000722	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
374930000723	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
374930000724	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
374930000725	acyl-activating enzyme (AAE) consensus motif; other site
374930000726	putative AMP binding site [chemical binding]; other site
374930000727	putative active site [active]
374930000728	putative CoA binding site [chemical binding]; other site
374930000729	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
374930000730	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
374930000731	Glycoprotease family; Region: Peptidase_M22; pfam00814
374930000732	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
374930000733	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
374930000734	DEAD_2; Region: DEAD_2; pfam06733
374930000735	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
374930000736	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
374930000737	active site
374930000738	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
374930000739	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
374930000740	colicin uptake protein TolR; Provisional; Region: PRK11024
374930000741	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
374930000742	TolA C-terminal; Region: TolA; pfam06519
374930000743	translocation protein TolB; Provisional; Region: tolB; PRK01742
374930000744	TolB amino-terminal domain; Region: TolB_N; pfam04052
374930000745	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
374930000746	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
374930000747	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
374930000748	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
374930000749	ligand binding site [chemical binding]; other site
374930000750	potential frameshift: common BLAST hit: gi|113460425|ref|YP_718487.1| possible tRNA/rRNA methyltransferase [Haemophilus somnus 129PT]
374930000751	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
374930000752	Rrf2 family protein; Region: rrf2_super; TIGR00738
374930000753	cysteine desulfurase; Provisional; Region: PRK14012
374930000754	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
374930000755	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930000756	catalytic residue [active]
374930000757	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
374930000758	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
374930000759	trimerization site [polypeptide binding]; other site
374930000760	active site
374930000761	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
374930000762	DnaJ domain; Region: DnaJ; pfam00226
374930000763	Fe-S protein assembly co-chaperone HscB; Region: hscB; TIGR00714
374930000764	HSP70 interaction site [polypeptide binding]; other site
374930000765	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
374930000766	Protein of unknown function DUF2625; Region: DUF2625; pfam10946
374930000767	chaperone protein HscA; Provisional; Region: hscA; PRK05183
374930000768	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
374930000769	nucleotide binding site [chemical binding]; other site
374930000770	putative NEF/HSP70 interaction site [polypeptide binding]; other site
374930000771	SBD interface [polypeptide binding]; other site
374930000772	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
374930000773	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
374930000774	catalytic loop [active]
374930000775	iron binding site [ion binding]; other site
374930000776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2975
374930000777	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
374930000778	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
374930000779	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
374930000780	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
374930000781	dimer interface [polypeptide binding]; other site
374930000782	motif 1; other site
374930000783	active site
374930000784	motif 2; other site
374930000785	motif 3; other site
374930000786	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
374930000787	anticodon binding site; other site
374930000788	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
374930000789	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
374930000790	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
374930000791	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
374930000792	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
374930000793	non-specific DNA binding site [nucleotide binding]; other site
374930000794	salt bridge; other site
374930000795	sequence-specific DNA binding site [nucleotide binding]; other site
374930000796	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
374930000797	TPR repeat; Region: TPR_11; pfam13414
374930000798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
374930000799	TPR motif; other site
374930000800	binding surface
374930000801	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
374930000802	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930000803	FeS/SAM binding site; other site
374930000804	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
374930000805	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
374930000806	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
374930000807	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
374930000808	metal binding site [ion binding]; metal-binding site
374930000809	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
374930000810	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
374930000811	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
374930000812	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
374930000813	ABC-ATPase subunit  interface; other site
374930000814	dimer interface [polypeptide binding]; other site
374930000815	putative PBP binding regions; other site
374930000816	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
374930000817	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
374930000818	ABC-ATPase subunit  interface; other site
374930000819	dimer interface [polypeptide binding]; other site
374930000820	putative PBP binding regions; other site
374930000821	Putative transcription activator [Transcription]; Region: TenA; COG0819
374930000822	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
374930000823	NMT1/THI5 like; Region: NMT1; pfam09084
374930000824	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
374930000825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930000826	dimer interface [polypeptide binding]; other site
374930000827	conserved gate region; other site
374930000828	putative PBP binding loops; other site
374930000829	ABC-ATPase subunit interface; other site
374930000830	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
374930000831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930000832	Walker A/P-loop; other site
374930000833	ATP binding site [chemical binding]; other site
374930000834	Q-loop/lid; other site
374930000835	ABC transporter signature motif; other site
374930000836	Walker B; other site
374930000837	D-loop; other site
374930000838	H-loop/switch region; other site
374930000839	Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002
374930000840	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
374930000841	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
374930000842	NAD binding site [chemical binding]; other site
374930000843	homodimer interface [polypeptide binding]; other site
374930000844	active site
374930000845	substrate binding site [chemical binding]; other site
374930000846	muropeptide transporter; Reviewed; Region: ampG; PRK11902
374930000847	AmpG-like permease; Region: 2A0125; TIGR00901
374930000848	adenylate kinase; Reviewed; Region: adk; PRK00279
374930000849	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
374930000850	AMP-binding site [chemical binding]; other site
374930000851	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
374930000852	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
374930000853	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
374930000854	Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043
374930000855	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
374930000856	4Fe-4S binding domain; Region: Fer4_5; pfam12801
374930000857	4Fe-4S binding domain; Region: Fer4_6; pfam12837
374930000858	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
374930000859	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
374930000860	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
374930000861	[4Fe-4S] binding site [ion binding]; other site
374930000862	molybdopterin cofactor binding site; other site
374930000863	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
374930000864	molybdopterin cofactor binding site; other site
374930000865	Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062
374930000866	ferredoxin-type protein NapF; Region: napF; TIGR00402
374930000867	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
374930000868	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
374930000869	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
374930000870	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
374930000871	hypothetical protein; Provisional; Region: PRK11702
374930000872	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
374930000873	primosome assembly protein PriA; Validated; Region: PRK05580
374930000874	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930000875	ATP binding site [chemical binding]; other site
374930000876	putative Mg++ binding site [ion binding]; other site
374930000877	helicase superfamily c-terminal domain; Region: HELICc; smart00490
374930000878	nucleotide binding region [chemical binding]; other site
374930000879	ATP-binding site [chemical binding]; other site
374930000880	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
374930000881	Domain of unknown function DUF20; Region: UPF0118; pfam01594
374930000882	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
374930000883	Nitrogen regulatory protein P-II; Region: P-II; smart00938
374930000884	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
374930000885	MPT binding site; other site
374930000886	trimer interface [polypeptide binding]; other site
374930000887	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
374930000888	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
374930000889	HD domain; Region: HD_4; pfam13328
374930000890	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
374930000891	synthetase active site [active]
374930000892	NTP binding site [chemical binding]; other site
374930000893	metal binding site [ion binding]; metal-binding site
374930000894	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
374930000895	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
374930000896	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
374930000897	active site
374930000898	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
374930000899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
374930000900	potential frameshift: common BLAST hit: gi|24378571|ref|NP_720526.1| putative site-specific DNA-methyltransferase
374930000901	potential frameshift: common BLAST hit: gi|68248938|ref|YP_248050.1| 23S rRNA (uracil-5-)-methyltransferase [Haemophilus influenzae]
374930000902	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
374930000903	Recombination protein O N terminal; Region: RecO_N; pfam11967
374930000904	Recombination protein O C terminal; Region: RecO_C; pfam02565
374930000905	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
374930000906	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
374930000907	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
374930000908	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930000909	FeS/SAM binding site; other site
374930000910	elongation factor P; Validated; Region: PRK00529
374930000911	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
374930000912	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
374930000913	RNA binding site [nucleotide binding]; other site
374930000914	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
374930000915	RNA binding site [nucleotide binding]; other site
374930000916	Primosomal replication protein N'' [DNA replication, recombination, and repair]; Region: PriC; COG3923
374930000917	potential frameshift: common BLAST hit: gi|113461157|ref|YP_719225.1| possible permease [Haemophilus somnus 129PT]
374930000918	ribonuclease T; Provisional; Region: PRK05168
374930000919	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
374930000920	active site
374930000921	catalytic site [active]
374930000922	substrate binding site [chemical binding]; other site
374930000923	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
374930000924	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
374930000925	dimer interface [polypeptide binding]; other site
374930000926	active site
374930000927	metal binding site [ion binding]; metal-binding site
374930000928	glutathione binding site [chemical binding]; other site
374930000929	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
374930000930	oligomeric interface; other site
374930000931	putative active site [active]
374930000932	homodimer interface [polypeptide binding]; other site
374930000933	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
374930000934	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930000935	S-adenosylmethionine binding site [chemical binding]; other site
374930000936	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
374930000937	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
374930000938	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
374930000939	dimer interface [polypeptide binding]; other site
374930000940	anticodon binding site; other site
374930000941	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
374930000942	homodimer interface [polypeptide binding]; other site
374930000943	motif 1; other site
374930000944	active site
374930000945	motif 2; other site
374930000946	GAD domain; Region: GAD; pfam02938
374930000947	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
374930000948	active site
374930000949	motif 3; other site
374930000950	Predicted transcriptional regulator [Transcription]; Region: COG2932
374930000951	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
374930000952	Catalytic site [active]
374930000953	HTH-like domain; Region: HTH_21; pfam13276
374930000954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
374930000955	Integrase core domain; Region: rve; pfam00665
374930000956	Integrase core domain; Region: rve_2; pfam13333
374930000957	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
374930000958	Helix-turn-helix domain; Region: HTH_28; pfam13518
374930000959	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
374930000960	dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438
374930000961	hypothetical protein; Validated; Region: PRK00110
374930000962	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
374930000963	active site
374930000964	putative DNA-binding cleft [nucleotide binding]; other site
374930000965	dimer interface [polypeptide binding]; other site
374930000966	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
374930000967	RuvA N terminal domain; Region: RuvA_N; pfam01330
374930000968	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
374930000969	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
374930000970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930000971	Walker A motif; other site
374930000972	ATP binding site [chemical binding]; other site
374930000973	Walker B motif; other site
374930000974	arginine finger; other site
374930000975	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
374930000976	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
374930000977	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
374930000978	active site
374930000979	Int/Topo IB signature motif; other site
374930000980	phenyl proprionate permease family protein; Region: 2A0127; TIGR00902
374930000981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930000982	putative substrate translocation pore; other site
374930000983	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
374930000984	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
374930000985	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
374930000986	RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250
374930000987	Putative transcriptional regulator [Transcription]; Region: COG1678
374930000988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
374930000989	RNA methyltransferase, RsmE family; Region: TIGR00046
374930000990	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
374930000991	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
374930000992	putative active site [active]
374930000993	catalytic triad [active]
374930000994	putative dimer interface [polypeptide binding]; other site
374930000995	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
374930000996	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
374930000997	Transporter associated domain; Region: CorC_HlyC; smart01091
374930000998	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
374930000999	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
374930001000	amidase catalytic site [active]
374930001001	Zn binding residues [ion binding]; other site
374930001002	substrate binding site [chemical binding]; other site
374930001003	putative major pilin subunit; Provisional; Region: PRK10574
374930001004	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
374930001005	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
374930001006	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
374930001007	Walker A motif; other site
374930001008	ATP binding site [chemical binding]; other site
374930001009	Walker B motif; other site
374930001010	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
374930001011	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
374930001012	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
374930001013	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
374930001014	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
374930001015	transcription termination factor Rho; Provisional; Region: rho; PRK09376
374930001016	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
374930001017	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
374930001018	RNA binding site [nucleotide binding]; other site
374930001019	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
374930001020	multimer interface [polypeptide binding]; other site
374930001021	Walker A motif; other site
374930001022	ATP binding site [chemical binding]; other site
374930001023	Walker B motif; other site
374930001024	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
374930001025	dimerization interface [polypeptide binding]; other site
374930001026	DNA binding site [nucleotide binding]
374930001027	corepressor binding sites; other site
374930001028	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
374930001029	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
374930001030	DNA binding residues [nucleotide binding]
374930001031	dimer interface [polypeptide binding]; other site
374930001032	copper binding site [ion binding]; other site
374930001033	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930001034	metal-binding site [ion binding]
374930001035	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930001036	metal-binding site [ion binding]
374930001037	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930001038	metal-binding site [ion binding]
374930001039	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
374930001040	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930001041	metal-binding site [ion binding]
374930001042	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
374930001043	Soluble P-type ATPase [General function prediction only]; Region: COG4087
374930001044	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
374930001045	serine transporter; Region: stp; TIGR00814
374930001046	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
374930001047	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
374930001048	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
374930001049	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
374930001050	aromatic amino acid transport protein; Region: araaP; TIGR00837
374930001051	aminotransferase AlaT; Validated; Region: PRK09265
374930001052	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
374930001053	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930001054	homodimer interface [polypeptide binding]; other site
374930001055	catalytic residue [active]
374930001056	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
374930001057	isochorismate synthases; Region: isochor_syn; TIGR00543
374930001058	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
374930001059	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
374930001060	dimer interface [polypeptide binding]; other site
374930001061	tetramer interface [polypeptide binding]; other site
374930001062	PYR/PP interface [polypeptide binding]; other site
374930001063	TPP binding site [chemical binding]; other site
374930001064	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
374930001065	TPP-binding site; other site
374930001066	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
374930001067	Protein of unknown function (DUF726); Region: DUF726; pfam05277
374930001068	metabolite-proton symporter; Region: 2A0106; TIGR00883
374930001069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930001070	putative substrate translocation pore; other site
374930001071	uridine phosphorylase; Provisional; Region: PRK11178
374930001072	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
374930001073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
374930001074	MOSC domain; Region: MOSC; pfam03473
374930001075	hypothetical protein; Provisional; Region: PRK01752
374930001076	SEC-C motif; Region: SEC-C; pfam02810
374930001077	SEC-C motif; Region: SEC-C; pfam02810
374930001078	hypothetical protein; Reviewed; Region: PRK01637
374930001079	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
374930001080	Sulfatase; Region: Sulfatase; cl17466
374930001081	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
374930001082	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
374930001083	HIGH motif; other site
374930001084	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
374930001085	active site
374930001086	KMSKS motif; other site
374930001087	ribonuclease PH; Reviewed; Region: rph; PRK00173
374930001088	Ribonuclease PH; Region: RNase_PH_bact; cd11362
374930001089	hexamer interface [polypeptide binding]; other site
374930001090	active site
374930001091	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930001092	active site
374930001093	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
374930001094	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
374930001095	putative metal binding site [ion binding]; other site
374930001096	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
374930001097	HSP70 interaction site [polypeptide binding]; other site
374930001098	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
374930001099	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
374930001100	FMN binding site [chemical binding]; other site
374930001101	active site
374930001102	catalytic residues [active]
374930001103	substrate binding site [chemical binding]; other site
374930001104	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
374930001105	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
374930001106	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
374930001107	DNA binding residues [nucleotide binding]
374930001108	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
374930001109	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
374930001110	FAD binding domain; Region: FAD_binding_4; pfam01565
374930001111	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
374930001112	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
374930001113	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
374930001114	HAMP domain; Region: HAMP; pfam00672
374930001115	Histidine kinase; Region: HisKA_3; pfam07730
374930001116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930001117	ATP binding site [chemical binding]; other site
374930001118	Mg2+ binding site [ion binding]; other site
374930001119	G-X-G motif; other site
374930001120	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
374930001121	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
374930001122	homooctamer interface [polypeptide binding]; other site
374930001123	active site
374930001124	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
374930001125	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
374930001126	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
374930001127	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
374930001128	Surface antigen; Region: Bac_surface_Ag; pfam01103
374930001129	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
374930001130	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930001131	N-terminal plug; other site
374930001132	ligand-binding site [chemical binding]; other site
374930001133	potential frameshift: common BLAST hit: gi|16272219|ref|NP_438430.1| lipopolysaccharide biosynthesis protein [Haemophilus influenzae Rd]
374930001134	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
374930001135	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
374930001136	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
374930001137	active site
374930001138	dimerization interface [polypeptide binding]; other site
374930001139	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
374930001140	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
374930001141	Ligand binding site; other site
374930001142	metal-binding site
374930001143	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
374930001144	30S subunit binding site; other site
374930001145	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
374930001146	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
374930001147	dihydrodipicolinate synthase; Region: dapA; TIGR00674
374930001148	dimer interface [polypeptide binding]; other site
374930001149	active site
374930001150	catalytic residue [active]
374930001151	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
374930001152	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
374930001153	catalytic triad [active]
374930001154	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
374930001155	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
374930001156	TonB system transport protein ExbD, group 2; Region: ExbD_2; TIGR02804
374930001157	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
374930001158	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
374930001159	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
374930001160	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
374930001161	dimer interface [polypeptide binding]; other site
374930001162	ssDNA binding site [nucleotide binding]; other site
374930001163	tetramer (dimer of dimers) interface [polypeptide binding]; other site
374930001164	potential frameshift: common BLAST hit: gi|16272207|ref|NP_438418.1| excinuclease ABC subunit A [Haemophilus influenzae Rd KW20]
374930001165	potential frameshift: common BLAST hit: gi|68248855|ref|YP_247967.1| adhesion and penetration protein Hap [Haemophilus influenzae]
374930001166	potential frameshift: common BLAST hit: gi|68248855|ref|YP_247967.1| adhesion and penetration protein Hap [Haemophilus influenzae]
374930001167	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
374930001168	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
374930001169	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
374930001170	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
374930001171	Hemerythrin-like domain; Region: Hr-like; cd12108
374930001172	Fe binding site [ion binding]; other site
374930001173	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
374930001174	CPxP  motif; other site
374930001175	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
374930001176	potential frameshift: common BLAST hit: gi|68248848|ref|YP_247960.1| protein export protein SecD [Haemophilus influenzae 86-028NP]
374930001177	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
374930001178	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
374930001179	Protein export membrane protein; Region: SecD_SecF; pfam02355
374930001180	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
374930001181	Domain of unknown function DUF20; Region: UPF0118; pfam01594
374930001182	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
374930001183	ArsC family; Region: ArsC; pfam03960
374930001184	catalytic residues [active]
374930001185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
374930001186	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
374930001187	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
374930001188	substrate binding pocket [chemical binding]; other site
374930001189	membrane-bound complex binding site; other site
374930001190	hinge residues; other site
374930001191	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
374930001192	N-acetyl-D-glucosamine binding site [chemical binding]; other site
374930001193	catalytic residue [active]
374930001194	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
374930001195	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
374930001196	ATP binding site [chemical binding]; other site
374930001197	Mg++ binding site [ion binding]; other site
374930001198	motif III; other site
374930001199	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930001200	nucleotide binding region [chemical binding]; other site
374930001201	ATP-binding site [chemical binding]; other site
374930001202	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
374930001203	putative RNA binding site [nucleotide binding]; other site
374930001204	Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785
374930001205	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
374930001206	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
374930001207	RNase E interface [polypeptide binding]; other site
374930001208	trimer interface [polypeptide binding]; other site
374930001209	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
374930001210	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
374930001211	RNase E interface [polypeptide binding]; other site
374930001212	trimer interface [polypeptide binding]; other site
374930001213	active site
374930001214	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
374930001215	putative nucleic acid binding region [nucleotide binding]; other site
374930001216	G-X-X-G motif; other site
374930001217	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
374930001218	RNA binding site [nucleotide binding]; other site
374930001219	domain interface; other site
374930001220	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
374930001221	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
374930001222	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
374930001223	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
374930001224	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
374930001225	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
374930001226	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
374930001227	putative DNA binding site [nucleotide binding]; other site
374930001228	putative Zn2+ binding site [ion binding]; other site
374930001229	AsnC family; Region: AsnC_trans_reg; pfam01037
374930001230	Predicted permeases [General function prediction only]; Region: RarD; COG2962
374930001231	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
374930001232	GMP synthase; Reviewed; Region: guaA; PRK00074
374930001233	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
374930001234	AMP/PPi binding site [chemical binding]; other site
374930001235	candidate oxyanion hole; other site
374930001236	catalytic triad [active]
374930001237	potential glutamine specificity residues [chemical binding]; other site
374930001238	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
374930001239	ATP Binding subdomain [chemical binding]; other site
374930001240	Ligand Binding sites [chemical binding]; other site
374930001241	Dimerization subdomain; other site
374930001242	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
374930001243	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
374930001244	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
374930001245	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
374930001246	active site
374930001247	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
374930001248	HTH domain; Region: HTH_11; cl17392
374930001249	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
374930001250	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
374930001251	Predicted membrane protein [Function unknown]; Region: COG3223
374930001252	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
374930001253	HemY protein N-terminus; Region: HemY_N; pfam07219
374930001254	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
374930001255	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
374930001256	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
374930001257	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
374930001258	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
374930001259	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
374930001260	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
374930001261	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
374930001262	serine acetyltransferase; Provisional; Region: cysE; PRK11132
374930001263	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
374930001264	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
374930001265	trimer interface [polypeptide binding]; other site
374930001266	active site
374930001267	substrate binding site [chemical binding]; other site
374930001268	CoA binding site [chemical binding]; other site
374930001269	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
374930001270	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
374930001271	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
374930001272	shikimate binding site; other site
374930001273	NAD(P) binding site [chemical binding]; other site
374930001274	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
374930001275	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
374930001276	transmembrane helices; other site
374930001277	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
374930001278	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
374930001279	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
374930001280	homodimer interface [polypeptide binding]; other site
374930001281	NADP binding site [chemical binding]; other site
374930001282	substrate binding site [chemical binding]; other site
374930001283	potential frameshift: common BLAST hit: gi|68249309|ref|YP_248421.1| L-fucose permease [Haemophilus influenzae 86-028NP]
374930001284	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
374930001285	intersubunit interface [polypeptide binding]; other site
374930001286	active site
374930001287	Zn2+ binding site [ion binding]; other site
374930001288	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
374930001289	L-fuculokinase; Region: fuculo_kin_coli; TIGR02628
374930001290	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
374930001291	nucleotide binding site [chemical binding]; other site
374930001292	L-fucose isomerase; Provisional; Region: fucI; PRK10991
374930001293	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
374930001294	hexamer (dimer of trimers) interface [polypeptide binding]; other site
374930001295	trimer interface [polypeptide binding]; other site
374930001296	substrate binding site [chemical binding]; other site
374930001297	Mn binding site [ion binding]; other site
374930001298	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
374930001299	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
374930001300	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
374930001301	ATP-dependent helicase HepA; Validated; Region: PRK04914
374930001302	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930001303	ATP binding site [chemical binding]; other site
374930001304	putative Mg++ binding site [ion binding]; other site
374930001305	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930001306	nucleotide binding region [chemical binding]; other site
374930001307	ATP-binding site [chemical binding]; other site
374930001308	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
374930001309	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
374930001310	active site
374930001311	Rhomboid family; Region: Rhomboid; pfam01694
374930001312	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
374930001313	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
374930001314	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
374930001315	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
374930001316	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
374930001317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930001318	dimer interface [polypeptide binding]; other site
374930001319	conserved gate region; other site
374930001320	ABC-ATPase subunit interface; other site
374930001321	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
374930001322	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
374930001323	Walker A/P-loop; other site
374930001324	ATP binding site [chemical binding]; other site
374930001325	Q-loop/lid; other site
374930001326	ABC transporter signature motif; other site
374930001327	Walker B; other site
374930001328	D-loop; other site
374930001329	H-loop/switch region; other site
374930001330	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
374930001331	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
374930001332	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
374930001333	active site
374930001334	motif I; other site
374930001335	motif II; other site
374930001336	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
374930001337	putative uracil binding site [chemical binding]; other site
374930001338	putative active site [active]
374930001339	potential frameshift: common BLAST hit: gi|68248825|ref|YP_247937.1| putative type I restriction-modification system [Haemophilus]
374930001340	AAA domain; Region: AAA_13; pfam13166
374930001341	AAA domain; Region: AAA_13; pfam13166
374930001342	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930001343	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
374930001344	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930001345	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
374930001346	HsdM N-terminal domain; Region: HsdM_N; pfam12161
374930001347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930001348	S-adenosylmethionine binding site [chemical binding]; other site
374930001349	oligopeptidase A; Provisional; Region: PRK10911
374930001350	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
374930001351	active site
374930001352	Zn binding site [ion binding]; other site
374930001353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
374930001354	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
374930001355	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
374930001356	peptide binding site [polypeptide binding]; other site
374930001357	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
374930001358	dimerization interface [polypeptide binding]; other site
374930001359	active site
374930001360	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
374930001361	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
374930001362	active site
374930001363	potential frameshift: common BLAST hit: gi|68248814|ref|YP_247926.1| DNA adenine methylase [Haemophilus influenzae 86-028NP]
374930001364	potential frameshift: common BLAST hit: gi|68248814|ref|YP_247926.1| DNA adenine methylase [Haemophilus influenzae 86-028NP]
374930001365	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
374930001366	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
374930001367	active site
374930001368	dimer interface [polypeptide binding]; other site
374930001369	metal binding site [ion binding]; metal-binding site
374930001370	shikimate kinase; Reviewed; Region: aroK; PRK00131
374930001371	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
374930001372	ADP binding site [chemical binding]; other site
374930001373	magnesium binding site [ion binding]; other site
374930001374	putative shikimate binding site; other site
374930001375	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
374930001376	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
374930001377	active site
374930001378	metal binding site [ion binding]; metal-binding site
374930001379	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
374930001380	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
374930001381	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
374930001382	RimM N-terminal domain; Region: RimM; pfam01782
374930001383	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
374930001384	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
374930001385	potential frameshift: common BLAST hit: gi|68248805|ref|YP_247917.1| selenide, water dikinase [Haemophilus influenzae 86-028NP]
374930001386	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
374930001387	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
374930001388	putative acyl-acceptor binding pocket; other site
374930001389	hypothetical protein; Provisional; Region: PRK10621
374930001390	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
374930001391	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
374930001392	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
374930001393	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
374930001394	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
374930001395	Tetramer interface [polypeptide binding]; other site
374930001396	active site
374930001397	FMN-binding site [chemical binding]; other site
374930001398	hypothetical protein; Provisional; Region: PRK11281
374930001399	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
374930001400	Mechanosensitive ion channel; Region: MS_channel; pfam00924
374930001401	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
374930001402	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
374930001403	acyl-activating enzyme (AAE) consensus motif; other site
374930001404	putative AMP binding site [chemical binding]; other site
374930001405	putative active site [active]
374930001406	putative CoA binding site [chemical binding]; other site
374930001407	potential frameshift: common BLAST hit: gi|68248798|ref|YP_247910.1| SeqA [Haemophilus influenzae 86-028NP]
374930001408	acyl-CoA esterase; Provisional; Region: PRK10673
374930001409	PGAP1-like protein; Region: PGAP1; pfam07819
374930001410	flavodoxin FldA; Validated; Region: PRK09267
374930001411	ferric uptake regulator; Provisional; Region: fur; PRK09462
374930001412	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
374930001413	metal binding site 2 [ion binding]; metal-binding site
374930001414	putative DNA binding helix; other site
374930001415	metal binding site 1 [ion binding]; metal-binding site
374930001416	dimer interface [polypeptide binding]; other site
374930001417	structural Zn2+ binding site [ion binding]; other site
374930001418	glutamate dehydrogenase; Provisional; Region: PRK09414
374930001419	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
374930001420	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
374930001421	NAD(P) binding site [chemical binding]; other site
374930001422	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
374930001423	sec-independent translocase; Provisional; Region: PRK01770
374930001424	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
374930001425	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
374930001426	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
374930001427	DNA binding residues [nucleotide binding]
374930001428	putative dimer interface [polypeptide binding]; other site
374930001429	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
374930001430	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
374930001431	substrate binding site [chemical binding]; other site
374930001432	catalytic Zn binding site [ion binding]; other site
374930001433	NAD binding site [chemical binding]; other site
374930001434	structural Zn binding site [ion binding]; other site
374930001435	dimer interface [polypeptide binding]; other site
374930001436	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
374930001437	S-formylglutathione hydrolase; Region: PLN02442
374930001438	potential frameshift: common BLAST hit: gi|59800725|ref|YP_207437.1| IgA-specific metalloendopeptidase [Neisseria gonorrhoeae FA 1090]
374930001439	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
374930001440	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
374930001441	E3 interaction surface; other site
374930001442	lipoyl attachment site [posttranslational modification]; other site
374930001443	Pleckstrin homology-like domain; Region: PH-like; cl17171
374930001444	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
374930001445	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
374930001446	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869
374930001447	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
374930001448	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
374930001449	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
374930001450	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
374930001451	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
374930001452	catalytic loop [active]
374930001453	iron binding site [ion binding]; other site
374930001454	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
374930001455	FAD binding pocket [chemical binding]; other site
374930001456	FAD binding motif [chemical binding]; other site
374930001457	phosphate binding motif [ion binding]; other site
374930001458	beta-alpha-beta structure motif; other site
374930001459	NAD binding pocket [chemical binding]; other site
374930001460	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
374930001461	ApbE family; Region: ApbE; pfam02424
374930001462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
374930001463	potential frameshift: common BLAST hit: gi|68248779|ref|YP_247891.1| tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
374930001464	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
374930001465	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
374930001466	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
374930001467	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930001468	RNA binding surface [nucleotide binding]; other site
374930001469	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
374930001470	active site
374930001471	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
374930001472	potential frameshift: common BLAST hit: gi|68248784|ref|YP_247896.1| pyruvate formate-lyase 1 activating enzyme [Haemophilus influenzae]
374930001473	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
374930001474	Pyruvate formate lyase 1; Region: PFL1; cd01678
374930001475	coenzyme A binding site [chemical binding]; other site
374930001476	active site
374930001477	catalytic residues [active]
374930001478	glycine loop; other site
374930001479	formate transporter FocA; Region: formate_focA; TIGR04060
374930001480	fructokinase; Reviewed; Region: PRK09557
374930001481	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
374930001482	nucleotide binding site [chemical binding]; other site
374930001483	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
374930001484	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
374930001485	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
374930001486	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
374930001487	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
374930001488	glutathione reductase; Validated; Region: PRK06116
374930001489	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
374930001490	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
374930001491	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
374930001492	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
374930001493	hypothetical protein; Provisional; Region: PRK11193
374930001494	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
374930001495	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
374930001496	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
374930001497	dimer interface [polypeptide binding]; other site
374930001498	active site
374930001499	CoA binding pocket [chemical binding]; other site
374930001500	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
374930001501	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
374930001502	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
374930001503	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
374930001504	NAD(P) binding site [chemical binding]; other site
374930001505	homotetramer interface [polypeptide binding]; other site
374930001506	homodimer interface [polypeptide binding]; other site
374930001507	active site
374930001508	acyl carrier protein; Provisional; Region: acpP; PRK00982
374930001509	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
374930001510	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
374930001511	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
374930001512	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
374930001513	FtsH protease regulator HflK; Provisional; Region: PRK10930
374930001514	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
374930001515	FtsH protease regulator HflC; Provisional; Region: PRK11029
374930001516	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
374930001517	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
374930001518	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
374930001519	Kelch motif; Region: Kelch_1; pfam01344
374930001520	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
374930001521	DctM-like transporters; Region: DctM; pfam06808
374930001522	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
374930001523	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
374930001524	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
374930001525	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
374930001526	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
374930001527	putative active site cavity [active]
374930001528	N-acetylmannosamine kinase; Provisional; Region: PRK05082
374930001529	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
374930001530	nucleotide binding site [chemical binding]; other site
374930001531	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
374930001532	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
374930001533	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
374930001534	putative active site [active]
374930001535	N-acetylneuraminate lyase; Provisional; Region: PRK04147
374930001536	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
374930001537	inhibitor site; inhibition site
374930001538	active site
374930001539	dimer interface [polypeptide binding]; other site
374930001540	catalytic residue [active]
374930001541	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
374930001542	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
374930001543	active site
374930001544	trimer interface [polypeptide binding]; other site
374930001545	allosteric site; other site
374930001546	active site lid [active]
374930001547	hexamer (dimer of trimers) interface [polypeptide binding]; other site
374930001548	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
374930001549	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
374930001550	active site
374930001551	dimer interface [polypeptide binding]; other site
374930001552	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
374930001553	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
374930001554	trimer interface [polypeptide binding]; other site
374930001555	eyelet of channel; other site
374930001556	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
374930001557	active site
374930001558	RNA/DNA hybrid binding site [nucleotide binding]; other site
374930001559	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
374930001560	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
374930001561	active site
374930001562	catalytic site [active]
374930001563	substrate binding site [chemical binding]; other site
374930001564	GTP-binding protein Der; Reviewed; Region: PRK00093
374930001565	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
374930001566	G1 box; other site
374930001567	GTP/Mg2+ binding site [chemical binding]; other site
374930001568	Switch I region; other site
374930001569	G2 box; other site
374930001570	Switch II region; other site
374930001571	G3 box; other site
374930001572	G4 box; other site
374930001573	G5 box; other site
374930001574	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
374930001575	G1 box; other site
374930001576	GTP/Mg2+ binding site [chemical binding]; other site
374930001577	Switch I region; other site
374930001578	G2 box; other site
374930001579	G3 box; other site
374930001580	Switch II region; other site
374930001581	G4 box; other site
374930001582	G5 box; other site
374930001583	potential frameshift: common BLAST hit: gi|68248743|ref|YP_247855.1| sugar efflux transporter [Haemophilus influenzae 86-028NP]
374930001584	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
374930001585	trimer interface [polypeptide binding]; other site
374930001586	active site
374930001587	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
374930001588	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
374930001589	Sugar specificity; other site
374930001590	Pyrimidine base specificity; other site
374930001591	ATP-binding site [chemical binding]; other site
374930001592	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
374930001593	dimer interface [polypeptide binding]; other site
374930001594	substrate binding site [chemical binding]; other site
374930001595	metal binding sites [ion binding]; metal-binding site
374930001596	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
374930001597	cystathionine beta-lyase; Provisional; Region: PRK08114
374930001598	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
374930001599	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930001600	catalytic residue [active]
374930001601	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
374930001602	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
374930001603	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930001604	Uncharacterized integral membrane protein [Function unknown]; Region: COG5413
374930001605	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
374930001606	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
374930001607	metal binding site [ion binding]; metal-binding site
374930001608	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
374930001609	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
374930001610	putative ATP binding site [chemical binding]; other site
374930001611	putative substrate interface [chemical binding]; other site
374930001612	murein transglycosylase A; Provisional; Region: mltA; PRK11162
374930001613	MltA specific insert domain; Region: MltA; smart00925
374930001614	3D domain; Region: 3D; pfam06725
374930001615	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
374930001616	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
374930001617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930001618	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
374930001619	putative RNA binding site [nucleotide binding]; other site
374930001620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930001621	S-adenosylmethionine binding site [chemical binding]; other site
374930001622	potential frameshift: common BLAST hit: gi|68248728|ref|YP_247840.1| hemin receptor [Haemophilus influenzae 86-028NP]
374930001623	Integrase core domain; Region: rve_3; cl15866
374930001624	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
374930001625	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
374930001626	C-terminal domain interface [polypeptide binding]; other site
374930001627	GSH binding site (G-site) [chemical binding]; other site
374930001628	dimer interface [polypeptide binding]; other site
374930001629	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
374930001630	dimer interface [polypeptide binding]; other site
374930001631	N-terminal domain interface [polypeptide binding]; other site
374930001632	substrate binding pocket (H-site) [chemical binding]; other site
374930001633	seryl-tRNA synthetase; Provisional; Region: PRK05431
374930001634	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
374930001635	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
374930001636	dimer interface [polypeptide binding]; other site
374930001637	active site
374930001638	motif 1; other site
374930001639	motif 2; other site
374930001640	motif 3; other site
374930001641	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
374930001642	Uncharacterized conserved protein [Function unknown]; Region: COG2966
374930001643	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
374930001644	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
374930001645	Domain of unknown function DUF21; Region: DUF21; pfam01595
374930001646	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
374930001647	Transporter associated domain; Region: CorC_HlyC; smart01091
374930001648	signal recognition particle protein; Provisional; Region: PRK10867
374930001649	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
374930001650	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
374930001651	P loop; other site
374930001652	GTP binding site [chemical binding]; other site
374930001653	Signal peptide binding domain; Region: SRP_SPB; pfam02978
374930001654	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
374930001655	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
374930001656	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
374930001657	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
374930001658	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930001659	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930001660	Divergent AAA domain; Region: AAA_4; pfam04326
374930001661	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
374930001662	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
374930001663	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
374930001664	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
374930001665	HsdM N-terminal domain; Region: HsdM_N; pfam12161
374930001666	Methyltransferase domain; Region: Methyltransf_26; pfam13659
374930001667	Uncharacterized conserved protein [Function unknown]; Region: COG0327
374930001668	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
374930001669	heat shock protein 90; Provisional; Region: PRK05218
374930001670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930001671	ATP binding site [chemical binding]; other site
374930001672	Mg2+ binding site [ion binding]; other site
374930001673	G-X-G motif; other site
374930001674	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
374930001675	ArsC family; Region: ArsC; pfam03960
374930001676	putative catalytic residues [active]
374930001677	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
374930001678	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
374930001679	metal binding site [ion binding]; metal-binding site
374930001680	dimer interface [polypeptide binding]; other site
374930001681	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
374930001682	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
374930001683	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
374930001684	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
374930001685	Walker A/P-loop; other site
374930001686	ATP binding site [chemical binding]; other site
374930001687	Q-loop/lid; other site
374930001688	ABC transporter signature motif; other site
374930001689	Walker B; other site
374930001690	D-loop; other site
374930001691	H-loop/switch region; other site
374930001692	potential frameshift: common BLAST hit: gi|30995355|ref|NP_438272.2| iron(III) ABC transporter permease protein [Haemophilus influenzae]
374930001693	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
374930001694	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
374930001695	Methyltransferase domain; Region: Methyltransf_31; pfam13847
374930001696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930001697	S-adenosylmethionine binding site [chemical binding]; other site
374930001698	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
374930001699	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
374930001700	Glycerate kinase family; Region: Gly_kinase; pfam02595
374930001701	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
374930001702	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
374930001703	catalytic residue [active]
374930001704	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
374930001705	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
374930001706	nucleotide binding site [chemical binding]; other site
374930001707	substrate binding site [chemical binding]; other site
374930001708	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
374930001709	dimer interface [polypeptide binding]; other site
374930001710	putative threonine allosteric regulatory site; other site
374930001711	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
374930001712	putative threonine allosteric regulatory site; other site
374930001713	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
374930001714	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
374930001715	homoserine kinase; Region: thrB; TIGR00191
374930001716	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
374930001717	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
374930001718	threonine synthase; Validated; Region: PRK09225
374930001719	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
374930001720	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930001721	catalytic residue [active]
374930001722	cystathionine gamma-synthase; Reviewed; Region: PRK08247
374930001723	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
374930001724	homodimer interface [polypeptide binding]; other site
374930001725	substrate-cofactor binding pocket; other site
374930001726	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930001727	catalytic residue [active]
374930001728	potential frameshift: common BLAST hit: gi|68248635|ref|YP_247747.1| D-lactate dehydrogenase [Haemophilus influenzae 86-028NP]
374930001729	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
374930001730	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
374930001731	catalytic residues [active]
374930001732	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
374930001733	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
374930001734	active site
374930001735	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
374930001736	substrate binding site [chemical binding]; other site
374930001737	potential frameshift: common BLAST hit: gi|68248628|ref|YP_247740.1| cysteinyl-tRNA synthetase [Haemophilus influenzae 86-028NP]
374930001738	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
374930001739	dinuclear metal binding motif [ion binding]; other site
374930001740	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
374930001741	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
374930001742	active site
374930001743	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
374930001744	catalytic triad [active]
374930001745	dimer interface [polypeptide binding]; other site
374930001746	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
374930001747	ATP cone domain; Region: ATP-cone; pfam03477
374930001748	Class III ribonucleotide reductase; Region: RNR_III; cd01675
374930001749	effector binding site; other site
374930001750	active site
374930001751	Zn binding site [ion binding]; other site
374930001752	glycine loop; other site
374930001753	nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987
374930001754	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
374930001755	active site
374930001756	NTP binding site [chemical binding]; other site
374930001757	metal binding triad [ion binding]; metal-binding site
374930001758	antibiotic binding site [chemical binding]; other site
374930001759	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
374930001760	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
374930001761	dimer interface [polypeptide binding]; other site
374930001762	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
374930001763	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
374930001764	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
374930001765	DNA repair protein RecN; Region: recN; TIGR00634
374930001766	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
374930001767	Walker A/P-loop; other site
374930001768	ATP binding site [chemical binding]; other site
374930001769	Q-loop/lid; other site
374930001770	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
374930001771	ABC transporter signature motif; other site
374930001772	Walker B; other site
374930001773	D-loop; other site
374930001774	H-loop/switch region; other site
374930001775	potential frameshift: common BLAST hit: gi|16272043|ref|NP_438242.1| glutamate-ammonia-ligase adenylyltransferase [Haemophilus]
374930001776	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
374930001777	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
374930001778	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
374930001779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930001780	ATP binding site [chemical binding]; other site
374930001781	Mg2+ binding site [ion binding]; other site
374930001782	G-X-G motif; other site
374930001783	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
374930001784	ATP binding site [chemical binding]; other site
374930001785	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
374930001786	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
374930001787	active site
374930001788	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
374930001789	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
374930001790	tRNA threonylcarbamoyl adenosine modification protein YjeE; Region: T6A_YjeE; TIGR00150
374930001791	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
374930001792	catalytic center binding site [active]
374930001793	ATP binding site [chemical binding]; other site
374930001794	poly(A) polymerase; Region: pcnB; TIGR01942
374930001795	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
374930001796	active site
374930001797	NTP binding site [chemical binding]; other site
374930001798	metal binding triad [ion binding]; metal-binding site
374930001799	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
374930001800	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
374930001801	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
374930001802	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
374930001803	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
374930001804	Competence protein; Region: Competence; pfam03772
374930001805	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
374930001806	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
374930001807	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
374930001808	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
374930001809	Walker A/P-loop; other site
374930001810	ATP binding site [chemical binding]; other site
374930001811	Q-loop/lid; other site
374930001812	ABC transporter signature motif; other site
374930001813	Walker B; other site
374930001814	D-loop; other site
374930001815	H-loop/switch region; other site
374930001816	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
374930001817	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
374930001818	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
374930001819	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
374930001820	Ligand binding site; other site
374930001821	oligomer interface; other site
374930001822	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
374930001823	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
374930001824	GIY-YIG motif/motif A; other site
374930001825	active site
374930001826	catalytic site [active]
374930001827	putative DNA binding site [nucleotide binding]; other site
374930001828	metal binding site [ion binding]; metal-binding site
374930001829	UvrB/uvrC motif; Region: UVR; pfam02151
374930001830	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
374930001831	Helix-hairpin-helix motif; Region: HHH; pfam00633
374930001832	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
374930001833	mannonate dehydratase; Provisional; Region: PRK03906
374930001834	mannonate dehydratase; Region: uxuA; TIGR00695
374930001835	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
374930001836	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
374930001837	DNA-binding site [nucleotide binding]; DNA binding site
374930001838	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
374930001839	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
374930001840	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
374930001841	putative NAD(P) binding site [chemical binding]; other site
374930001842	catalytic Zn binding site [ion binding]; other site
374930001843	structural Zn binding site [ion binding]; other site
374930001844	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
374930001845	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
374930001846	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
374930001847	DctM-like transporters; Region: DctM; pfam06808
374930001848	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
374930001849	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
374930001850	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
374930001851	substrate binding site [chemical binding]; other site
374930001852	ATP binding site [chemical binding]; other site
374930001853	D-mannonate oxidoreductase; Provisional; Region: PRK08277
374930001854	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
374930001855	putative NAD(P) binding site [chemical binding]; other site
374930001856	active site
374930001857	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
374930001858	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
374930001859	active site
374930001860	intersubunit interface [polypeptide binding]; other site
374930001861	catalytic residue [active]
374930001862	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
374930001863	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
374930001864	PhnA protein; Region: PhnA; pfam03831
374930001865	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398
374930001866	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
374930001867	YccA-like proteins; Region: YccA_like; cd10433
374930001868	Predicted membrane protein [Function unknown]; Region: COG3768
374930001869	TIGR01620 family protein; Region: hyp_HI0043
374930001870	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
374930001871	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
374930001872	active site
374930001873	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
374930001874	putative catalytic site [active]
374930001875	putative phosphate binding site [ion binding]; other site
374930001876	active site
374930001877	metal binding site A [ion binding]; metal-binding site
374930001878	DNA binding site [nucleotide binding]
374930001879	putative AP binding site [nucleotide binding]; other site
374930001880	putative metal binding site B [ion binding]; other site
374930001881	TIGR01619 family protein; Region: hyp_HI0040
374930001882	Family of unknown function (DUF695); Region: DUF695; pfam05117
374930001883	rod shape-determining protein MreD; Region: MreD; cl01087
374930001884	potential frameshift: common BLAST hit: gi|68248589|ref|YP_247701.1| rod shape-determining protein MreC [Haemophilus influenzae]
374930001885	potential frameshift: common BLAST hit: gi|16272013|ref|NP_438211.1| rod shape-determining protein [Haemophilus influenzae Rd KW20]
374930001886	rod shape-determining protein MreB; Provisional; Region: PRK13927
374930001887	MreB and similar proteins; Region: MreB_like; cd10225
374930001888	nucleotide binding site [chemical binding]; other site
374930001889	Mg binding site [ion binding]; other site
374930001890	putative protofilament interaction site [polypeptide binding]; other site
374930001891	RodZ interaction site [polypeptide binding]; other site
374930001892	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
374930001893	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
374930001894	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
374930001895	putative transporter; Validated; Region: PRK03818
374930001896	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
374930001897	TrkA-C domain; Region: TrkA_C; pfam02080
374930001898	TrkA-C domain; Region: TrkA_C; pfam02080
374930001899	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
374930001900	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
374930001901	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
374930001902	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
374930001903	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
374930001904	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
374930001905	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
374930001906	rare lipoprotein A; Region: rlpA; TIGR00413
374930001907	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
374930001908	Sporulation related domain; Region: SPOR; pfam05036
374930001909	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
374930001910	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
374930001911	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
374930001912	hypothetical protein; Provisional; Region: PRK04998
374930001913	lipoate-protein ligase B; Provisional; Region: PRK14342
374930001914	lipoyl synthase; Provisional; Region: PRK05481
374930001915	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930001916	FeS/SAM binding site; other site
374930001917	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
374930001918	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
374930001919	putative active site [active]
374930001920	(T/H)XGH motif; other site
374930001921	citrate lyase subunit gamma; Provisional; Region: PRK13253
374930001922	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
374930001923	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
374930001924	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
374930001925	holo-ACP synthase CitX; Region: citrate_citX; TIGR03124
374930001926	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
374930001927	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
374930001928	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
374930001929	transmembrane helices; other site
374930001930	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
374930001931	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
374930001932	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930001933	FeS/SAM binding site; other site
374930001934	TRAM domain; Region: TRAM; pfam01938
374930001935	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
374930001936	ligand binding site [chemical binding]; other site
374930001937	active site
374930001938	UGI interface [polypeptide binding]; other site
374930001939	catalytic site [active]
374930001940	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
374930001941	GTP-binding protein LepA; Provisional; Region: PRK05433
374930001942	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
374930001943	G1 box; other site
374930001944	putative GEF interaction site [polypeptide binding]; other site
374930001945	GTP/Mg2+ binding site [chemical binding]; other site
374930001946	Switch I region; other site
374930001947	G2 box; other site
374930001948	G3 box; other site
374930001949	Switch II region; other site
374930001950	G4 box; other site
374930001951	G5 box; other site
374930001952	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
374930001953	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
374930001954	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
374930001955	signal peptidase I; Provisional; Region: PRK10861
374930001956	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
374930001957	Catalytic site [active]
374930001958	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
374930001959	ribonuclease III; Reviewed; Region: rnc; PRK00102
374930001960	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
374930001961	dimerization interface [polypeptide binding]; other site
374930001962	active site
374930001963	metal binding site [ion binding]; metal-binding site
374930001964	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
374930001965	dsRNA binding site [nucleotide binding]; other site
374930001966	potential frameshift: common BLAST hit: gi|68248564|ref|YP_247676.1| GTP-binding protein Era [Haemophilus influenzae 86-028NP]
374930001967	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
374930001968	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
374930001969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930001970	S-adenosylmethionine binding site [chemical binding]; other site
374930001971	DNA polymerase III, psi subunit; Region: DNA_III_psi; TIGR00664
374930001972	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
374930001973	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
374930001974	Coenzyme A binding pocket [chemical binding]; other site
374930001975	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
374930001976	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
374930001977	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
374930001978	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
374930001979	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
374930001980	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
374930001981	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
374930001982	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
374930001983	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
374930001984	molybdopterin cofactor binding site; other site
374930001985	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
374930001986	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
374930001987	metal-binding heat shock protein; Provisional; Region: PRK00016
374930001988	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
374930001989	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
374930001990	active site
374930001991	motif I; other site
374930001992	motif II; other site
374930001993	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
374930001994	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
374930001995	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
374930001996	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
374930001997	acyl-activating enzyme (AAE) consensus motif; other site
374930001998	putative AMP binding site [chemical binding]; other site
374930001999	putative active site [active]
374930002000	putative CoA binding site [chemical binding]; other site
374930002001	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
374930002002	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
374930002003	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
374930002004	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
374930002005	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
374930002006	catalytic site [active]
374930002007	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
374930002008	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
374930002009	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
374930002010	Zn2+ binding site [ion binding]; other site
374930002011	Mg2+ binding site [ion binding]; other site
374930002012	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
374930002013	synthetase active site [active]
374930002014	NTP binding site [chemical binding]; other site
374930002015	metal binding site [ion binding]; metal-binding site
374930002016	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
374930002017	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
374930002018	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
374930002019	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
374930002020	generic binding surface II; other site
374930002021	ssDNA binding site; other site
374930002022	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930002023	ATP binding site [chemical binding]; other site
374930002024	putative Mg++ binding site [ion binding]; other site
374930002025	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930002026	nucleotide binding region [chemical binding]; other site
374930002027	ATP-binding site [chemical binding]; other site
374930002028	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
374930002029	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
374930002030	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
374930002031	phosphate binding site [ion binding]; other site
374930002032	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
374930002033	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
374930002034	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
374930002035	putative dimerization interface [polypeptide binding]; other site
374930002036	AzlC protein; Region: AzlC; cl00570
374930002037	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
374930002038	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
374930002039	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
374930002040	G1 box; other site
374930002041	putative GEF interaction site [polypeptide binding]; other site
374930002042	GTP/Mg2+ binding site [chemical binding]; other site
374930002043	Switch I region; other site
374930002044	G2 box; other site
374930002045	G3 box; other site
374930002046	Switch II region; other site
374930002047	G4 box; other site
374930002048	G5 box; other site
374930002049	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
374930002050	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
374930002051	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
374930002052	NAD binding site [chemical binding]; other site
374930002053	homotetramer interface [polypeptide binding]; other site
374930002054	homodimer interface [polypeptide binding]; other site
374930002055	substrate binding site [chemical binding]; other site
374930002056	active site
374930002057	potential frameshift: common BLAST hit: gi|68250330|ref|YP_249442.1| exoribonuclease II [Haemophilus influenzae 86-028NP]
374930002058	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
374930002059	sensor histidine kinase inhibitor, KipI family; Region: TIGR00370
374930002060	biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724
374930002061	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
374930002062	putative active site [active]
374930002063	potential frameshift: common BLAST hit: gi|68250326|ref|YP_249438.1| Mn2+ and Fe2+ transporter of the NRAMP family [Haemophilus]
374930002064	argininosuccinate synthase; Provisional; Region: PRK13820
374930002065	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
374930002066	ANP binding site [chemical binding]; other site
374930002067	Substrate Binding Site II [chemical binding]; other site
374930002068	Substrate Binding Site I [chemical binding]; other site
374930002069	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
374930002070	ATP binding site [chemical binding]; other site
374930002071	active site
374930002072	substrate binding site [chemical binding]; other site
374930002073	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
374930002074	Transglycosylase; Region: Transgly; pfam00912
374930002075	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
374930002076	Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474
374930002077	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
374930002078	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
374930002079	active site
374930002080	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
374930002081	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
374930002082	metal binding triad; other site
374930002083	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
374930002084	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
374930002085	Zn2+ binding site [ion binding]; other site
374930002086	Mg2+ binding site [ion binding]; other site
374930002087	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
374930002088	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
374930002089	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
374930002090	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
374930002091	Mg++ binding site [ion binding]; other site
374930002092	putative catalytic motif [active]
374930002093	substrate binding site [chemical binding]; other site
374930002094	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
374930002095	catalytic site [active]
374930002096	putative active site [active]
374930002097	putative substrate binding site [chemical binding]; other site
374930002098	dimer interface [polypeptide binding]; other site
374930002099	GTPase RsgA; Reviewed; Region: PRK12288
374930002100	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
374930002101	RNA binding site [nucleotide binding]; other site
374930002102	homodimer interface [polypeptide binding]; other site
374930002103	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
374930002104	GTPase/Zn-binding domain interface [polypeptide binding]; other site
374930002105	GTP/Mg2+ binding site [chemical binding]; other site
374930002106	G4 box; other site
374930002107	G5 box; other site
374930002108	G1 box; other site
374930002109	Switch I region; other site
374930002110	G2 box; other site
374930002111	G3 box; other site
374930002112	Switch II region; other site
374930002113	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
374930002114	dimerization domain swap beta strand [polypeptide binding]; other site
374930002115	regulatory protein interface [polypeptide binding]; other site
374930002116	active site
374930002117	regulatory phosphorylation site [posttranslational modification]; other site
374930002118	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
374930002119	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
374930002120	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
374930002121	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
374930002122	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
374930002123	HPr interaction site; other site
374930002124	glycerol kinase (GK) interaction site [polypeptide binding]; other site
374930002125	active site
374930002126	phosphorylation site [posttranslational modification]
374930002127	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
374930002128	TIGR00156 family protein; Region: TIGR00156
374930002129	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
374930002130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
374930002131	active site
374930002132	phosphorylation site [posttranslational modification]
374930002133	intermolecular recognition site; other site
374930002134	dimerization interface [polypeptide binding]; other site
374930002135	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
374930002136	DNA binding site [nucleotide binding]
374930002137	sensor protein QseC; Provisional; Region: PRK10337
374930002138	HAMP domain; Region: HAMP; pfam00672
374930002139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
374930002140	dimer interface [polypeptide binding]; other site
374930002141	phosphorylation site [posttranslational modification]
374930002142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930002143	ATP binding site [chemical binding]; other site
374930002144	Mg2+ binding site [ion binding]; other site
374930002145	G-X-G motif; other site
374930002146	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
374930002147	multifunctional aminopeptidase A; Provisional; Region: PRK00913
374930002148	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
374930002149	interface (dimer of trimers) [polypeptide binding]; other site
374930002150	Substrate-binding/catalytic site; other site
374930002151	Zn-binding sites [ion binding]; other site
374930002152	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
374930002153	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
374930002154	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
374930002155	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
374930002156	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
374930002157	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
374930002158	THF binding site; other site
374930002159	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
374930002160	substrate binding site [chemical binding]; other site
374930002161	THF binding site; other site
374930002162	zinc-binding site [ion binding]; other site
374930002163	Uncharacterized conserved protein [Function unknown]; Region: COG1434
374930002164	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
374930002165	putative active site [active]
374930002166	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
374930002167	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
374930002168	potential frameshift: common BLAST hit: gi|68250303|ref|YP_249415.1| CMP-N-acetylneuraminate-beta-galactosamide-alpha-2
374930002169	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
374930002170	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
374930002171	putative ADP-binding pocket [chemical binding]; other site
374930002172	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930002173	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
374930002174	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
374930002175	active site
374930002176	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
374930002177	GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195
374930002178	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
374930002179	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
374930002180	molybdenum-pterin binding domain; Region: Mop; TIGR00638
374930002181	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
374930002182	molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256
374930002183	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
374930002184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930002185	dimer interface [polypeptide binding]; other site
374930002186	conserved gate region; other site
374930002187	putative PBP binding loops; other site
374930002188	ABC-ATPase subunit interface; other site
374930002189	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
374930002190	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930002191	Walker A/P-loop; other site
374930002192	ATP binding site [chemical binding]; other site
374930002193	Q-loop/lid; other site
374930002194	ABC transporter signature motif; other site
374930002195	Walker B; other site
374930002196	D-loop; other site
374930002197	H-loop/switch region; other site
374930002198	molybdenum-pterin binding domain; Region: Mop; TIGR00638
374930002199	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
374930002200	Na2 binding site [ion binding]; other site
374930002201	putative substrate binding site 1 [chemical binding]; other site
374930002202	Na binding site 1 [ion binding]; other site
374930002203	putative substrate binding site 2 [chemical binding]; other site
374930002204	endonuclease III; Provisional; Region: PRK10702
374930002205	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
374930002206	minor groove reading motif; other site
374930002207	helix-hairpin-helix signature motif; other site
374930002208	substrate binding pocket [chemical binding]; other site
374930002209	active site
374930002210	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
374930002211	electron transport complex RsxE subunit; Provisional; Region: PRK12405
374930002212	electron transport complex protein RnfG; Validated; Region: PRK01908
374930002213	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
374930002214	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
374930002215	SLBB domain; Region: SLBB; pfam10531
374930002216	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
374930002217	electron transport complex protein RnfB; Provisional; Region: PRK05113
374930002218	Putative Fe-S cluster; Region: FeS; pfam04060
374930002219	4Fe-4S binding domain; Region: Fer4; pfam00037
374930002220	electron transport complex protein RsxA; Provisional; Region: PRK05151
374930002221	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
374930002222	putative inner membrane peptidase; Provisional; Region: PRK11778
374930002223	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
374930002224	tandem repeat interface [polypeptide binding]; other site
374930002225	oligomer interface [polypeptide binding]; other site
374930002226	active site residues [active]
374930002227	hypothetical protein; Provisional; Region: PRK01904
374930002228	hypothetical protein; Provisional; Region: PRK03641
374930002229	TIGR01666 family membrane protein; Region: YCCS
374930002230	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
374930002231	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
374930002232	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
374930002233	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
374930002234	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
374930002235	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
374930002236	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
374930002237	Uncharacterized conserved protein [Function unknown]; Region: COG3025
374930002238	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
374930002239	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
374930002240	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
374930002241	active site
374930002242	motif I; other site
374930002243	motif II; other site
374930002244	KpsF/GutQ family protein; Region: kpsF; TIGR00393
374930002245	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
374930002246	putative active site [active]
374930002247	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
374930002248	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
374930002249	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
374930002250	Hemerythrin-like domain; Region: Hr-like; cd12108
374930002251	Fe binding site [ion binding]; other site
374930002252	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
374930002253	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930002254	FeS/SAM binding site; other site
374930002255	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
374930002256	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
374930002257	trimer interface [polypeptide binding]; other site
374930002258	dimer interface [polypeptide binding]; other site
374930002259	putative active site [active]
374930002260	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
374930002261	MoaE interaction surface [polypeptide binding]; other site
374930002262	MoeB interaction surface [polypeptide binding]; other site
374930002263	thiocarboxylated glycine; other site
374930002264	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
374930002265	MoaE homodimer interface [polypeptide binding]; other site
374930002266	MoaD interaction [polypeptide binding]; other site
374930002267	active site residues [active]
374930002268	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
374930002269	mce related protein; Region: MCE; pfam02470
374930002270	mce related protein; Region: MCE; pfam02470
374930002271	mce related protein; Region: MCE; pfam02470
374930002272	mce related protein; Region: MCE; pfam02470
374930002273	mce related protein; Region: MCE; pfam02470
374930002274	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
374930002275	Paraquat-inducible protein A; Region: PqiA; pfam04403
374930002276	Paraquat-inducible protein A; Region: PqiA; pfam04403
374930002277	ProP expression regulator; Provisional; Region: PRK04950
374930002278	ProQ/FINO family; Region: ProQ; smart00945
374930002279	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
374930002280	KOW motif; Region: KOW; pfam00467
374930002281	carboxy-terminal protease; Provisional; Region: PRK11186
374930002282	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
374930002283	protein binding site [polypeptide binding]; other site
374930002284	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
374930002285	Catalytic dyad [active]
374930002286	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
374930002287	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
374930002288	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
374930002289	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
374930002290	Peptidase M15; Region: Peptidase_M15_3; cl01194
374930002291	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
374930002292	active site
374930002293	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
374930002294	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
374930002295	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
374930002296	TPP-binding site [chemical binding]; other site
374930002297	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
374930002298	PYR/PP interface [polypeptide binding]; other site
374930002299	dimer interface [polypeptide binding]; other site
374930002300	TPP binding site [chemical binding]; other site
374930002301	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
374930002302	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
374930002303	E3 interaction surface; other site
374930002304	lipoyl attachment site [posttranslational modification]; other site
374930002305	e3 binding domain; Region: E3_binding; pfam02817
374930002306	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
374930002307	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
374930002308	dimer interface [polypeptide binding]; other site
374930002309	putative radical transfer pathway; other site
374930002310	diiron center [ion binding]; other site
374930002311	tyrosyl radical; other site
374930002312	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
374930002313	ATP cone domain; Region: ATP-cone; pfam03477
374930002314	Class I ribonucleotide reductase; Region: RNR_I; cd01679
374930002315	active site
374930002316	dimer interface [polypeptide binding]; other site
374930002317	catalytic residues [active]
374930002318	effector binding site; other site
374930002319	R2 peptide binding site; other site
374930002320	outer membrane lipoprotein; Provisional; Region: PRK11023
374930002321	BON domain; Region: BON; pfam04972
374930002322	BON domain; Region: BON; cl02771
374930002323	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
374930002324	dimer interface [polypeptide binding]; other site
374930002325	active site
374930002326	TIGR00252 family protein; Region: TIGR00252
374930002327	LppC putative lipoprotein; Region: LppC; pfam04348
374930002328	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
374930002329	putative ligand binding site [chemical binding]; other site
374930002330	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
374930002331	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
374930002332	putative SAM binding site [chemical binding]; other site
374930002333	putative homodimer interface [polypeptide binding]; other site
374930002334	protease TldD; Provisional; Region: tldD; PRK10735
374930002335	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
374930002336	NlpC/P60 family; Region: NLPC_P60; pfam00877
374930002337	Integrase core domain; Region: rve; pfam00665
374930002338	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
374930002339	D-lactate dehydrogenase; Provisional; Region: PRK11183
374930002340	FAD binding domain; Region: FAD_binding_4; pfam01565
374930002341	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
374930002342	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
374930002343	predicted active site [active]
374930002344	catalytic triad [active]
374930002345	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
374930002346	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
374930002347	active site
374930002348	multimer interface [polypeptide binding]; other site
374930002349	cytidylate kinase; Provisional; Region: cmk; PRK00023
374930002350	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
374930002351	CMP-binding site; other site
374930002352	The sites determining sugar specificity; other site
374930002353	potential frameshift: common BLAST hit: gi|16273139|ref|NP_439376.1| 30S ribosomal protein S1 [Haemophilus influenzae Rd KW20]
374930002354	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
374930002355	IHF dimer interface [polypeptide binding]; other site
374930002356	IHF - DNA interface [nucleotide binding]; other site
374930002357	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
374930002358	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
374930002359	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
374930002360	binding surface
374930002361	TPR motif; other site
374930002362	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
374930002363	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
374930002364	active site
374930002365	dimer interface [polypeptide binding]; other site
374930002366	translation initiation factor Sui1; Validated; Region: PRK06824
374930002367	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
374930002368	putative rRNA binding site [nucleotide binding]; other site
374930002369	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
374930002370	DNA replication initiation factor; Validated; Region: PRK06893
374930002371	uracil-xanthine permease; Region: ncs2; TIGR00801
374930002372	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930002373	active site
374930002374	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
374930002375	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930002376	Walker A motif; other site
374930002377	ATP binding site [chemical binding]; other site
374930002378	Walker B motif; other site
374930002379	DNA polymerase III subunit delta'; Validated; Region: PRK08485
374930002380	arginine finger; other site
374930002381	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
374930002382	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
374930002383	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930002384	active site
374930002385	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
374930002386	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
374930002387	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
374930002388	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
374930002389	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
374930002390	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
374930002391	E3 interaction surface; other site
374930002392	lipoyl attachment site [posttranslational modification]; other site
374930002393	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
374930002394	E3 interaction surface; other site
374930002395	lipoyl attachment site [posttranslational modification]; other site
374930002396	e3 binding domain; Region: E3_binding; pfam02817
374930002397	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
374930002398	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
374930002399	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
374930002400	dimer interface [polypeptide binding]; other site
374930002401	TPP-binding site [chemical binding]; other site
374930002402	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
374930002403	active site
374930002404	dimer interfaces [polypeptide binding]; other site
374930002405	catalytic residues [active]
374930002406	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
374930002407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
374930002408	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
374930002409	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
374930002410	nucleotide binding site [chemical binding]; other site
374930002411	potential frameshift: common BLAST hit: gi|16273157|ref|NP_439394.1| heat shock protein [Haemophilus influenzae Rd KW20]
374930002412	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
374930002413	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
374930002414	putative catalytic cysteine [active]
374930002415	Predicted membrane protein [Function unknown]; Region: COG2860
374930002416	UPF0126 domain; Region: UPF0126; pfam03458
374930002417	UPF0126 domain; Region: UPF0126; pfam03458
374930002418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930002419	putative substrate translocation pore; other site
374930002420	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
374930002421	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
374930002422	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
374930002423	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930002424	RNA binding surface [nucleotide binding]; other site
374930002425	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
374930002426	active site
374930002427	uracil binding [chemical binding]; other site
374930002428	Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955
374930002429	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
374930002430	Malic enzyme, N-terminal domain; Region: malic; pfam00390
374930002431	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
374930002432	putative NAD(P) binding site [chemical binding]; other site
374930002433	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
374930002434	potential frameshift: common BLAST hit: gi|68250222|ref|YP_249334.1| predicted phosphoglycerol transferase-like protein [Haemophilus]
374930002435	potential frameshift: common BLAST hit: gi|68250221|ref|YP_249333.1| excinuclease ABC subunit B [Haemophilus influenzae 86-028NP]
374930002436	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
374930002437	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
374930002438	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
374930002439	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
374930002440	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
374930002441	non-specific DNA binding site [nucleotide binding]; other site
374930002442	salt bridge; other site
374930002443	sequence-specific DNA binding site [nucleotide binding]; other site
374930002444	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
374930002445	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930002446	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930002447	ABC transporter; Region: ABC_tran_2; pfam12848
374930002448	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930002449	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
374930002450	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
374930002451	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
374930002452	Helicase; Region: Helicase_RecD; pfam05127
374930002453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
374930002454	Coenzyme A binding pocket [chemical binding]; other site
374930002455	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
374930002456	transcription-repair coupling factor; Provisional; Region: PRK10689
374930002457	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
374930002458	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930002459	ATP binding site [chemical binding]; other site
374930002460	putative Mg++ binding site [ion binding]; other site
374930002461	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930002462	nucleotide binding region [chemical binding]; other site
374930002463	ATP-binding site [chemical binding]; other site
374930002464	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
374930002465	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
374930002466	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
374930002467	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
374930002468	protein binding site [polypeptide binding]; other site
374930002469	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
374930002470	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
374930002471	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
374930002472	potential frameshift: common BLAST hit: gi|68250209|ref|YP_249321.1| folylpolyglutamate synthase [Haemophilus influenzae 86-028NP]
374930002473	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
374930002474	putative active site [active]
374930002475	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
374930002476	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
374930002477	DNA gyrase subunit A; Validated; Region: PRK05560
374930002478	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
374930002479	CAP-like domain; other site
374930002480	active site
374930002481	primary dimer interface [polypeptide binding]; other site
374930002482	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002483	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002484	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002485	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002486	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002487	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
374930002488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930002489	S-adenosylmethionine binding site [chemical binding]; other site
374930002490	potential frameshift: common BLAST hit: gi|16273189|ref|NP_439427.1| hydroxyacylglutathione hydrolase [Haemophilus influenzae Rd KW20]
374930002491	tellurite resistance protein TehB; Provisional; Region: PRK12335
374930002492	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
374930002493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930002494	S-adenosylmethionine binding site [chemical binding]; other site
374930002495	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
374930002496	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
374930002497	active site
374930002498	HIGH motif; other site
374930002499	KMSKS motif; other site
374930002500	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
374930002501	tRNA binding surface [nucleotide binding]; other site
374930002502	anticodon binding site; other site
374930002503	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
374930002504	dimer interface [polypeptide binding]; other site
374930002505	putative tRNA-binding site [nucleotide binding]; other site
374930002506	antiporter inner membrane protein; Provisional; Region: PRK11670
374930002507	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
374930002508	Walker A motif; other site
374930002509	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
374930002510	dimer interface [polypeptide binding]; other site
374930002511	FMN binding site [chemical binding]; other site
374930002512	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
374930002513	ligand binding site; other site
374930002514	tetramer interface; other site
374930002515	Integrase core domain; Region: rve; pfam00665
374930002516	ribosome maturation protein RimP; Reviewed; Region: PRK00092
374930002517	Sm and related proteins; Region: Sm_like; cl00259
374930002518	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
374930002519	putative oligomer interface [polypeptide binding]; other site
374930002520	putative RNA binding site [nucleotide binding]; other site
374930002521	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
374930002522	NusA N-terminal domain; Region: NusA_N; pfam08529
374930002523	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
374930002524	RNA binding site [nucleotide binding]; other site
374930002525	homodimer interface [polypeptide binding]; other site
374930002526	NusA-like KH domain; Region: KH_5; pfam13184
374930002527	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
374930002528	G-X-X-G motif; other site
374930002529	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
374930002530	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
374930002531	translation initiation factor IF-2; Region: IF-2; TIGR00487
374930002532	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
374930002533	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
374930002534	G1 box; other site
374930002535	putative GEF interaction site [polypeptide binding]; other site
374930002536	GTP/Mg2+ binding site [chemical binding]; other site
374930002537	Switch I region; other site
374930002538	G2 box; other site
374930002539	G3 box; other site
374930002540	Switch II region; other site
374930002541	G4 box; other site
374930002542	G5 box; other site
374930002543	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
374930002544	Translation-initiation factor 2; Region: IF-2; pfam11987
374930002545	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
374930002546	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
374930002547	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
374930002548	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930002549	ATP binding site [chemical binding]; other site
374930002550	putative Mg++ binding site [ion binding]; other site
374930002551	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
374930002552	SIR2-like domain; Region: SIR2_2; pfam13289
374930002553	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
374930002554	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930002555	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
374930002556	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
374930002557	Methyltransferase domain; Region: Methyltransf_26; pfam13659
374930002558	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
374930002559	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
374930002560	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
374930002561	RNA binding site [nucleotide binding]; other site
374930002562	active site
374930002563	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
374930002564	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
374930002565	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
374930002566	prephenate dehydrogenase; Validated; Region: PRK08507
374930002567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
374930002568	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
374930002569	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
374930002570	Zn-ribbon-containing, possibly nucleic-acid-binding protein [General function prediction only]; Region: COG5595
374930002571	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
374930002572	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
374930002573	Aminotransferase class-V; Region: Aminotran_5; pfam00266
374930002574	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930002575	catalytic residue [active]
374930002576	Staphylococcal nuclease homologues; Region: SNc; smart00318
374930002577	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
374930002578	Catalytic site; other site
374930002579	hypothetical protein; Provisional; Region: PRK01821
374930002580	LrgB-like family; Region: LrgB; cl00596
374930002581	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
374930002582	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
374930002583	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
374930002584	ABC transporter ATPase component; Reviewed; Region: PRK11147
374930002585	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930002586	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930002587	ABC transporter; Region: ABC_tran_2; pfam12848
374930002588	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930002589	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
374930002590	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
374930002591	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
374930002592	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930002593	dimer interface [polypeptide binding]; other site
374930002594	conserved gate region; other site
374930002595	ABC-ATPase subunit interface; other site
374930002596	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
374930002597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930002598	dimer interface [polypeptide binding]; other site
374930002599	conserved gate region; other site
374930002600	putative PBP binding loops; other site
374930002601	ABC-ATPase subunit interface; other site
374930002602	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
374930002603	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
374930002604	Walker A/P-loop; other site
374930002605	ATP binding site [chemical binding]; other site
374930002606	Q-loop/lid; other site
374930002607	ABC transporter signature motif; other site
374930002608	Walker B; other site
374930002609	D-loop; other site
374930002610	H-loop/switch region; other site
374930002611	TOBE domain; Region: TOBE_2; pfam08402
374930002612	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
374930002613	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
374930002614	metal binding site [ion binding]; metal-binding site
374930002615	dimer interface [polypeptide binding]; other site
374930002616	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
374930002617	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
374930002618	dimerization interface [polypeptide binding]; other site
374930002619	DPS ferroxidase diiron center [ion binding]; other site
374930002620	ion pore; other site
374930002621	cytidine deaminase; Provisional; Region: PRK09027
374930002622	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
374930002623	active site
374930002624	catalytic motif [active]
374930002625	Zn binding site [ion binding]; other site
374930002626	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
374930002627	active site
374930002628	catalytic motif [active]
374930002629	Zn binding site [ion binding]; other site
374930002630	Methyltransferase domain; Region: Methyltransf_23; pfam13489
374930002631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930002632	S-adenosylmethionine binding site [chemical binding]; other site
374930002633	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
374930002634	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
374930002635	Na binding site [ion binding]; other site
374930002636	ribonuclease G; Provisional; Region: PRK11712
374930002637	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
374930002638	homodimer interface [polypeptide binding]; other site
374930002639	oligonucleotide binding site [chemical binding]; other site
374930002640	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
374930002641	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
374930002642	active site
374930002643	HIGH motif; other site
374930002644	nucleotide binding site [chemical binding]; other site
374930002645	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
374930002646	KMSKS motif; other site
374930002647	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
374930002648	Uncharacterized conserved protein [Function unknown]; Region: COG2983
374930002649	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
374930002650	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
374930002651	potential frameshift: common BLAST hit: gi|16273267|ref|NP_439508.1| glycogen branching enzyme [Haemophilus influenzae Rd KW20]
374930002652	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
374930002653	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
374930002654	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
374930002655	active site
374930002656	catalytic site [active]
374930002657	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
374930002658	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
374930002659	ligand binding site; other site
374930002660	oligomer interface; other site
374930002661	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
374930002662	dimer interface [polypeptide binding]; other site
374930002663	N-terminal domain interface [polypeptide binding]; other site
374930002664	sulfate 1 binding site; other site
374930002665	glycogen synthase; Provisional; Region: glgA; PRK00654
374930002666	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
374930002667	ADP-binding pocket [chemical binding]; other site
374930002668	homodimer interface [polypeptide binding]; other site
374930002669	glycogen phosphorylase; Provisional; Region: PRK14986
374930002670	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
374930002671	homodimer interface [polypeptide binding]; other site
374930002672	active site pocket [active]
374930002673	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
374930002674	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
374930002675	ligand binding site [chemical binding]; other site
374930002676	homodimer interface [polypeptide binding]; other site
374930002677	NAD(P) binding site [chemical binding]; other site
374930002678	trimer interface B [polypeptide binding]; other site
374930002679	trimer interface A [polypeptide binding]; other site
374930002680	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
374930002681	potential frameshift: common BLAST hit: gi|68250122|ref|YP_249234.1| pyridine nucleotide transhydrogenase [Haemophilus influenzae]
374930002682	Transcriptional regulator [Transcription]; Region: LysR; COG0583
374930002683	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
374930002684	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
374930002685	putative effector binding pocket; other site
374930002686	dimerization interface [polypeptide binding]; other site
374930002687	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
374930002688	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
374930002689	active site
374930002690	interdomain interaction site; other site
374930002691	putative metal-binding site [ion binding]; other site
374930002692	nucleotide binding site [chemical binding]; other site
374930002693	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
374930002694	domain I; other site
374930002695	DNA binding groove [nucleotide binding]
374930002696	phosphate binding site [ion binding]; other site
374930002697	domain II; other site
374930002698	domain III; other site
374930002699	nucleotide binding site [chemical binding]; other site
374930002700	catalytic site [active]
374930002701	domain IV; other site
374930002702	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
374930002703	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
374930002704	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
374930002705	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
374930002706	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
374930002707	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
374930002708	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
374930002709	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
374930002710	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
374930002711	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
374930002712	active site
374930002713	dimer interface [polypeptide binding]; other site
374930002714	motif 1; other site
374930002715	motif 2; other site
374930002716	motif 3; other site
374930002717	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
374930002718	anticodon binding site; other site
374930002719	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
374930002720	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
374930002721	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
374930002722	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
374930002723	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
374930002724	potential frameshift: common BLAST hit: gi|123440706|ref|YP_001004698.1| putative exported iron receptor protein [Yersinia enterocolitica]
374930002725	molybdenum-pterin binding domain; Region: Mop; TIGR00638
374930002726	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
374930002727	DsrC like protein; Region: DsrC; pfam04358
374930002728	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
374930002729	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
374930002730	Ligand Binding Site [chemical binding]; other site
374930002731	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukF; COG3006
374930002732	condesin subunit E; Provisional; Region: PRK05256
374930002733	potential frameshift: common BLAST hit: gi|68250109|ref|YP_249221.1| condesin subunit B [Haemophilus influenzae 86-028NP]
374930002734	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
374930002735	Uncharacterized conserved protein [Function unknown]; Region: COG3586
374930002736	exonuclease I; Provisional; Region: sbcB; PRK11779
374930002737	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
374930002738	active site
374930002739	catalytic site [active]
374930002740	substrate binding site [chemical binding]; other site
374930002741	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
374930002742	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
374930002743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
374930002744	putative active site [active]
374930002745	heme pocket [chemical binding]; other site
374930002746	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
374930002747	dimer interface [polypeptide binding]; other site
374930002748	phosphorylation site [posttranslational modification]
374930002749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930002750	ATP binding site [chemical binding]; other site
374930002751	Mg2+ binding site [ion binding]; other site
374930002752	G-X-G motif; other site
374930002753	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
374930002754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
374930002755	active site
374930002756	phosphorylation site [posttranslational modification]
374930002757	intermolecular recognition site; other site
374930002758	dimerization interface [polypeptide binding]; other site
374930002759	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
374930002760	DNA binding site [nucleotide binding]
374930002761	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
374930002762	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
374930002763	Walker A/P-loop; other site
374930002764	ATP binding site [chemical binding]; other site
374930002765	Q-loop/lid; other site
374930002766	ABC transporter signature motif; other site
374930002767	Walker B; other site
374930002768	D-loop; other site
374930002769	H-loop/switch region; other site
374930002770	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
374930002771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930002772	dimer interface [polypeptide binding]; other site
374930002773	conserved gate region; other site
374930002774	putative PBP binding loops; other site
374930002775	ABC-ATPase subunit interface; other site
374930002776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930002777	dimer interface [polypeptide binding]; other site
374930002778	conserved gate region; other site
374930002779	putative PBP binding loops; other site
374930002780	ABC-ATPase subunit interface; other site
374930002781	PBP superfamily domain; Region: PBP_like_2; cl17296
374930002782	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
374930002783	Ferritin-like domain; Region: Ferritin; pfam00210
374930002784	ferroxidase diiron center [ion binding]; other site
374930002785	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
374930002786	Ferritin-like domain; Region: Ferritin; pfam00210
374930002787	ferroxidase diiron center [ion binding]; other site
374930002788	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
374930002789	active site
374930002790	anthranilate synthase component I; Provisional; Region: PRK13564
374930002791	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
374930002792	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
374930002793	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
374930002794	Glutamine amidotransferase class-I; Region: GATase; pfam00117
374930002795	glutamine binding [chemical binding]; other site
374930002796	catalytic triad [active]
374930002797	potential frameshift: common BLAST hit: gi|120554009|ref|YP_958360.1| transglutaminase-like [Marinobacter aquaeolei VT8]
374930002798	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
374930002799	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
374930002800	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
374930002801	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
374930002802	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
374930002803	active site
374930002804	ribulose/triose binding site [chemical binding]; other site
374930002805	phosphate binding site [ion binding]; other site
374930002806	substrate (anthranilate) binding pocket [chemical binding]; other site
374930002807	product (indole) binding pocket [chemical binding]; other site
374930002808	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
374930002809	active site
374930002810	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
374930002811	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
374930002812	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
374930002813	HIGH motif; other site
374930002814	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
374930002815	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
374930002816	active site
374930002817	KMSKS motif; other site
374930002818	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
374930002819	tRNA binding surface [nucleotide binding]; other site
374930002820	anticodon binding site; other site
374930002821	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
374930002822	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
374930002823	putative active site [active]
374930002824	catalytic site [active]
374930002825	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
374930002826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
374930002827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
374930002828	DNA polymerase III subunit chi; Validated; Region: PRK05728
374930002829	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
374930002830	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
374930002831	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
374930002832	Ligand binding site; other site
374930002833	metal-binding site
374930002834	fumarate hydratase; Reviewed; Region: fumC; PRK00485
374930002835	Class II fumarases; Region: Fumarase_classII; cd01362
374930002836	active site
374930002837	tetramer interface [polypeptide binding]; other site
374930002838	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
374930002839	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
374930002840	active site
374930002841	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
374930002842	dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036
374930002843	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
374930002844	quinone interaction residues [chemical binding]; other site
374930002845	active site
374930002846	catalytic residues [active]
374930002847	FMN binding site [chemical binding]; other site
374930002848	substrate binding site [chemical binding]; other site
374930002849	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
374930002850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
374930002851	YcfA-like protein; Region: YcfA; pfam07927
374930002852	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
374930002853	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
374930002854	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
374930002855	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
374930002856	non-specific DNA binding site [nucleotide binding]; other site
374930002857	salt bridge; other site
374930002858	sequence-specific DNA binding site [nucleotide binding]; other site
374930002859	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
374930002860	non-specific DNA binding site [nucleotide binding]; other site
374930002861	salt bridge; other site
374930002862	sequence-specific DNA binding site [nucleotide binding]; other site
374930002863	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
374930002864	Catalytic site [active]
374930002865	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
374930002866	AntA/AntB antirepressor; Region: AntA; pfam08346
374930002867	lac repressor; Reviewed; Region: lacI; PRK09526
374930002868	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
374930002869	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
374930002870	active site
374930002871	DNA binding site [nucleotide binding]
374930002872	Int/Topo IB signature motif; other site
374930002873	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
374930002874	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
374930002875	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
374930002876	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
374930002877	ligand binding site [chemical binding]; other site
374930002878	flexible hinge region; other site
374930002879	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
374930002880	putative switch regulator; other site
374930002881	non-specific DNA interactions [nucleotide binding]; other site
374930002882	DNA binding site [nucleotide binding]
374930002883	sequence specific DNA binding site [nucleotide binding]; other site
374930002884	putative cAMP binding site [chemical binding]; other site
374930002885	universal stress protein UspE; Provisional; Region: PRK11175
374930002886	universal stress protein UspE; Provisional; Region: PRK11175
374930002887	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
374930002888	Ligand Binding Site [chemical binding]; other site
374930002889	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
374930002890	Ligand Binding Site [chemical binding]; other site
374930002891	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
374930002892	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
374930002893	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
374930002894	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
374930002895	active site
374930002896	substrate binding site [chemical binding]; other site
374930002897	cosubstrate binding site; other site
374930002898	catalytic site [active]
374930002899	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
374930002900	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
374930002901	dimerization interface [polypeptide binding]; other site
374930002902	putative ATP binding site [chemical binding]; other site
374930002903	potential frameshift: common BLAST hit: gi|16273335|ref|NP_439579.1| short chain dehydrogenase/reductase [Haemophilus influenzae Rd]
374930002904	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
374930002905	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
374930002906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930002907	catalytic residue [active]
374930002908	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
374930002909	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
374930002910	substrate binding site [chemical binding]; other site
374930002911	active site
374930002912	catalytic residues [active]
374930002913	heterodimer interface [polypeptide binding]; other site
374930002914	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
374930002915	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
374930002916	putative deacylase active site [active]
374930002917	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
374930002918	DNA-binding site [nucleotide binding]; DNA binding site
374930002919	RNA-binding motif; other site
374930002920	Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701
374930002921	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
374930002922	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
374930002923	probable active site [active]
374930002924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
374930002925	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
374930002926	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
374930002927	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
374930002928	Ligand Binding Site [chemical binding]; other site
374930002929	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
374930002930	active site residue [active]
374930002931	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
374930002932	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
374930002933	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
374930002934	substrate binding pocket [chemical binding]; other site
374930002935	chain length determination region; other site
374930002936	substrate-Mg2+ binding site; other site
374930002937	catalytic residues [active]
374930002938	aspartate-rich region 1; other site
374930002939	active site lid residues [active]
374930002940	aspartate-rich region 2; other site
374930002941	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
374930002942	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
374930002943	TPP-binding site; other site
374930002944	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
374930002945	PYR/PP interface [polypeptide binding]; other site
374930002946	dimer interface [polypeptide binding]; other site
374930002947	TPP binding site [chemical binding]; other site
374930002948	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
374930002949	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
374930002950	stringent starvation protein A; Provisional; Region: sspA; PRK09481
374930002951	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
374930002952	C-terminal domain interface [polypeptide binding]; other site
374930002953	putative GSH binding site (G-site) [chemical binding]; other site
374930002954	dimer interface [polypeptide binding]; other site
374930002955	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
374930002956	dimer interface [polypeptide binding]; other site
374930002957	N-terminal domain interface [polypeptide binding]; other site
374930002958	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
374930002959	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
374930002960	23S rRNA interface [nucleotide binding]; other site
374930002961	L3 interface [polypeptide binding]; other site
374930002962	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
374930002963	FAD binding site [chemical binding]; other site
374930002964	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
374930002965	AAA domain; Region: AAA_26; pfam13500
374930002966	YcgL domain; Region: YcgL; cl01189
374930002967	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
374930002968	homodecamer interface [polypeptide binding]; other site
374930002969	GTP cyclohydrolase I; Provisional; Region: PLN03044
374930002970	active site
374930002971	putative catalytic site residues [active]
374930002972	zinc binding site [ion binding]; other site
374930002973	GTP-CH-I/GFRP interaction surface; other site
374930002974	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
374930002975	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
374930002976	dimer interface [polypeptide binding]; other site
374930002977	putative functional site; other site
374930002978	putative MPT binding site; other site
374930002979	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
374930002980	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
374930002981	ATP binding site [chemical binding]; other site
374930002982	substrate interface [chemical binding]; other site
374930002983	dsDNA-mimic protein; Reviewed; Region: PRK05094
374930002984	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
374930002985	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
374930002986	catalytic residues [active]
374930002987	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
374930002988	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
374930002989	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
374930002990	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
374930002991	SelR domain; Region: SelR; pfam01641
374930002992	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
374930002993	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
374930002994	EamA-like transporter family; Region: EamA; cl17759
374930002995	Putative zinc-finger; Region: zf-HC2; pfam13490
374930002996	RNA polymerase sigma factor; Provisional; Region: PRK12530
374930002997	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
374930002998	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
374930002999	DNA binding residues [nucleotide binding]
374930003000	YadA-like C-terminal region; Region: YadA; pfam03895
374930003001	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
374930003002	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
374930003003	catalytic core [active]
374930003004	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
374930003005	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
374930003006	active site
374930003007	substrate binding site [chemical binding]; other site
374930003008	metal binding site [ion binding]; metal-binding site
374930003009	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
374930003010	dihydropteroate synthase; Region: DHPS; TIGR01496
374930003011	substrate binding pocket [chemical binding]; other site
374930003012	dimer interface [polypeptide binding]; other site
374930003013	inhibitor binding site; inhibition site
374930003014	potential frameshift: common BLAST hit: gi|68250004|ref|YP_249116.1| cell division protein FtsH homolog 1 [Haemophilus influenzae]
374930003015	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
374930003016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930003017	S-adenosylmethionine binding site [chemical binding]; other site
374930003018	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
374930003019	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
374930003020	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
374930003021	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
374930003022	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
374930003023	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
374930003024	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676
374930003025	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676
374930003026	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
374930003027	16S/18S rRNA binding site [nucleotide binding]; other site
374930003028	S13e-L30e interaction site [polypeptide binding]; other site
374930003029	25S rRNA binding site [nucleotide binding]; other site
374930003030	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
374930003031	ATP binding site [chemical binding]; other site
374930003032	3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174
374930003033	active site 2 [active]
374930003034	active site 1 [active]
374930003035	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
374930003036	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
374930003037	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
374930003038	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
374930003039	AAA domain; Region: AAA_30; pfam13604
374930003040	Family description; Region: UvrD_C_2; pfam13538
374930003041	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
374930003042	Family description; Region: UvrD_C_2; pfam13538
374930003043	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
374930003044	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
374930003045	23S rRNA binding site [nucleotide binding]; other site
374930003046	L21 binding site [polypeptide binding]; other site
374930003047	L13 binding site [polypeptide binding]; other site
374930003048	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
374930003049	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
374930003050	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
374930003051	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
374930003052	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
374930003053	active site
374930003054	phosphate binding residues; other site
374930003055	catalytic residues [active]
374930003056	potential frameshift: common BLAST hit: gi|68249985|ref|YP_249097.1| predicted arylsulfatase A-like enzyme [Haemophilus influenzae]
374930003057	potential frameshift: common BLAST hit: gi|68249984|ref|YP_249096.1| predicted serine/threonine protein phosphatase family protein
374930003058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930003059	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
374930003060	Walker A motif; other site
374930003061	ATP binding site [chemical binding]; other site
374930003062	Restriction endonuclease; Region: Mrr_cat; pfam04471
374930003063	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
374930003064	active site
374930003065	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296
374930003066	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
374930003067	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
374930003068	Fic/DOC family; Region: Fic; pfam02661
374930003069	Fic/DOC family; Region: Fic; cl00960
374930003070	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
374930003071	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
374930003072	NAD-dependent deacetylase; Provisional; Region: PRK00481
374930003073	NAD+ binding site [chemical binding]; other site
374930003074	substrate binding site [chemical binding]; other site
374930003075	Zn binding site [ion binding]; other site
374930003076	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
374930003077	Predicted transcriptional regulator [Transcription]; Region: COG2378
374930003078	WYL domain; Region: WYL; pfam13280
374930003079	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
374930003080	NlpC/P60 family; Region: NLPC_P60; pfam00877
374930003081	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
374930003082	IHF dimer interface [polypeptide binding]; other site
374930003083	IHF - DNA interface [nucleotide binding]; other site
374930003084	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
374930003085	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
374930003086	putative tRNA-binding site [nucleotide binding]; other site
374930003087	B3/4 domain; Region: B3_4; pfam03483
374930003088	tRNA synthetase B5 domain; Region: B5; smart00874
374930003089	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
374930003090	dimer interface [polypeptide binding]; other site
374930003091	motif 1; other site
374930003092	motif 3; other site
374930003093	motif 2; other site
374930003094	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
374930003095	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
374930003096	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
374930003097	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
374930003098	dimer interface [polypeptide binding]; other site
374930003099	motif 1; other site
374930003100	active site
374930003101	motif 2; other site
374930003102	motif 3; other site
374930003103	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
374930003104	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
374930003105	catalytic loop [active]
374930003106	iron binding site [ion binding]; other site
374930003107	dihydrodipicolinate reductase; Region: dapB; TIGR00036
374930003108	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
374930003109	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
374930003110	LysE type translocator; Region: LysE; cl00565
374930003111	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
374930003112	tetramer interfaces [polypeptide binding]; other site
374930003113	binuclear metal-binding site [ion binding]; other site
374930003114	thiamine-monophosphate kinase; Region: thiL; TIGR01379
374930003115	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
374930003116	ATP binding site [chemical binding]; other site
374930003117	dimerization interface [polypeptide binding]; other site
374930003118	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
374930003119	putative RNA binding site [nucleotide binding]; other site
374930003120	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
374930003121	homopentamer interface [polypeptide binding]; other site
374930003122	active site
374930003123	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
374930003124	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
374930003125	putative anticodon binding site; other site
374930003126	putative dimer interface [polypeptide binding]; other site
374930003127	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
374930003128	homodimer interface [polypeptide binding]; other site
374930003129	motif 1; other site
374930003130	motif 2; other site
374930003131	active site
374930003132	motif 3; other site
374930003133	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
374930003134	active site clefts [active]
374930003135	zinc binding site [ion binding]; other site
374930003136	dimer interface [polypeptide binding]; other site
374930003137	potential frameshift: common BLAST hit: gi|68250142|ref|YP_249254.1| ABC transporter ATP-binding protein [Haemophilus influenzae]
374930003138	potential frameshift: common BLAST hit: gi|68250142|ref|YP_249254.1| ABC transporter ATP-binding protein [Haemophilus influenzae]
374930003139	Abortive infection C-terminus; Region: Abi_C; pfam14355
374930003140	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
374930003141	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
374930003142	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
374930003143	putative ribose interaction site [chemical binding]; other site
374930003144	putative ADP binding site [chemical binding]; other site
374930003145	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
374930003146	active site
374930003147	nucleotide binding site [chemical binding]; other site
374930003148	HIGH motif; other site
374930003149	KMSKS motif; other site
374930003150	potential frameshift: common BLAST hit: gi|68249956|ref|YP_249068.1| lipid A biosynthesis lauroyl acyltransferase [Haemophilus]
374930003151	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
374930003152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
374930003153	ATP binding site [chemical binding]; other site
374930003154	Mg2+ binding site [ion binding]; other site
374930003155	G-X-G motif; other site
374930003156	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
374930003157	anchoring element; other site
374930003158	dimer interface [polypeptide binding]; other site
374930003159	ATP binding site [chemical binding]; other site
374930003160	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
374930003161	active site
374930003162	putative metal-binding site [ion binding]; other site
374930003163	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
374930003164	potential frameshift: common BLAST hit: gi|68249954|ref|YP_249066.1| DNA topoisomerase IV subunit A [Haemophilus influenzae 86-028NP]
374930003165	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
374930003166	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
374930003167	RimK-like ATP-grasp domain; Region: RimK; pfam08443
374930003168	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
374930003169	GSH binding site [chemical binding]; other site
374930003170	catalytic residues [active]
374930003171	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
374930003172	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
374930003173	dimer interface [polypeptide binding]; other site
374930003174	active site
374930003175	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
374930003176	Uncharacterized conserved protein [Function unknown]; Region: COG4121
374930003177	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
374930003178	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
374930003179	active site
374930003180	ATP binding site [chemical binding]; other site
374930003181	Phosphotransferase enzyme family; Region: APH; pfam01636
374930003182	substrate binding site [chemical binding]; other site
374930003183	dimer interface [polypeptide binding]; other site
374930003184	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
374930003185	EamA-like transporter family; Region: EamA; pfam00892
374930003186	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
374930003187	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
374930003188	active site
374930003189	metal-binding site
374930003190	potential frameshift: common BLAST hit: gi|68249945|ref|YP_249057.1| phosphorylcholine transferase [Haemophilus influenzae 86-028NP]
374930003191	potential frameshift: common BLAST hit: gi|68249944|ref|YP_249056.1| protease IV [Haemophilus influenzae 86-028NP]
374930003192	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
374930003193	putative FMN binding site [chemical binding]; other site
374930003194	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
374930003195	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
374930003196	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
374930003197	serine/threonine transporter SstT; Provisional; Region: PRK13628
374930003198	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
374930003199	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
374930003200	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
374930003201	Catalytic site [active]
374930003202	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
374930003203	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
374930003204	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
374930003205	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
374930003206	FtsX-like permease family; Region: FtsX; pfam02687
374930003207	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
374930003208	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
374930003209	Walker A/P-loop; other site
374930003210	ATP binding site [chemical binding]; other site
374930003211	Q-loop/lid; other site
374930003212	ABC transporter signature motif; other site
374930003213	Walker B; other site
374930003214	D-loop; other site
374930003215	H-loop/switch region; other site
374930003216	AAA domain; Region: AAA_26; pfam13500
374930003217	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
374930003218	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
374930003219	ADP binding site [chemical binding]; other site
374930003220	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
374930003221	Methyltransferase domain; Region: Methyltransf_11; pfam08241
374930003222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2830
374930003223	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
374930003224	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
374930003225	substrate-cofactor binding pocket; other site
374930003226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003227	catalytic residue [active]
374930003228	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
374930003229	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
374930003230	inhibitor-cofactor binding pocket; inhibition site
374930003231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003232	catalytic residue [active]
374930003233	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
374930003234	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
374930003235	FtsX-like permease family; Region: FtsX; pfam02687
374930003236	glycerate dehydrogenase; Provisional; Region: PRK06932
374930003237	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
374930003238	putative ligand binding site [chemical binding]; other site
374930003239	putative NAD binding site [chemical binding]; other site
374930003240	catalytic site [active]
374930003241	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
374930003242	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
374930003243	Uncharacterized conserved protein [Function unknown]; Region: COG2912
374930003244	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
374930003245	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
374930003246	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930003247	RDD family; Region: RDD; pfam06271
374930003248	peptide chain release factor 1; Validated; Region: prfA; PRK00591
374930003249	This domain is found in peptide chain release factors; Region: PCRF; smart00937
374930003250	RF-1 domain; Region: RF-1; pfam00472
374930003251	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
374930003252	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
374930003253	Sel1-like repeats; Region: SEL1; smart00671
374930003254	Sel1-like repeats; Region: SEL1; smart00671
374930003255	Sel1-like repeats; Region: SEL1; smart00671
374930003256	Sel1-like repeats; Region: SEL1; smart00671
374930003257	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
374930003258	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
374930003259	Sel1-like repeats; Region: SEL1; smart00671
374930003260	Sel1-like repeats; Region: SEL1; smart00671
374930003261	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
374930003262	binding surface
374930003263	TPR motif; other site
374930003264	Sel1-like repeats; Region: SEL1; smart00671
374930003265	Sel1-like repeats; Region: SEL1; smart00671
374930003266	Sel1-like repeats; Region: SEL1; smart00671
374930003267	Sel1-like repeats; Region: SEL1; smart00671
374930003268	Protein of unknown function, DUF462; Region: DUF462; cl01190
374930003269	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
374930003270	Protein of unknown function (DUF935); Region: DUF935; pfam06074
374930003271	pyruvate kinase; Provisional; Region: PRK05826
374930003272	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
374930003273	domain interfaces; other site
374930003274	active site
374930003275	potential frameshift: common BLAST hit: gi|68249840|ref|YP_248952.1| replicative DNA helicase [Haemophilus influenzae 86-028NP]
374930003276	potential frameshift: common BLAST hit: gi|16273469|ref|NP_439720.1| replicative DNA helicase [Haemophilus influenzae Rd KW20]
374930003277	alanine racemase; Reviewed; Region: alr; PRK00053
374930003278	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
374930003279	active site
374930003280	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
374930003281	substrate binding site [chemical binding]; other site
374930003282	catalytic residues [active]
374930003283	dimer interface [polypeptide binding]; other site
374930003284	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
374930003285	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
374930003286	active site
374930003287	dimer interface [polypeptide binding]; other site
374930003288	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
374930003289	dimer interface [polypeptide binding]; other site
374930003290	active site
374930003291	potential frameshift: common BLAST hit: gi|68249837|ref|YP_248949.1| UDP-glcNAc--lipooligosaccharide N-acetylglucosamine
374930003292	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
374930003293	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
374930003294	arginyl-tRNA synthetase; Region: argS; TIGR00456
374930003295	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
374930003296	active site
374930003297	HIGH motif; other site
374930003298	KMSK motif region; other site
374930003299	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
374930003300	tRNA binding surface [nucleotide binding]; other site
374930003301	anticodon binding site; other site
374930003302	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
374930003303	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
374930003304	putative valine binding site [chemical binding]; other site
374930003305	dimer interface [polypeptide binding]; other site
374930003306	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
374930003307	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882
374930003308	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
374930003309	PYR/PP interface [polypeptide binding]; other site
374930003310	dimer interface [polypeptide binding]; other site
374930003311	TPP binding site [chemical binding]; other site
374930003312	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
374930003313	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
374930003314	TPP-binding site [chemical binding]; other site
374930003315	dimer interface [polypeptide binding]; other site
374930003316	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
374930003317	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
374930003318	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
374930003319	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
374930003320	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
374930003321	putative active site [active]
374930003322	putative substrate binding site [chemical binding]; other site
374930003323	putative cosubstrate binding site; other site
374930003324	catalytic site [active]
374930003325	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
374930003326	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
374930003327	hinge; other site
374930003328	active site
374930003329	potential frameshift: common BLAST hit: gi|68249825|ref|YP_248937.1| modification methylase BepI-like [Haemophilus influenzae 86-028NP]
374930003330	recombination factor protein RarA; Reviewed; Region: PRK13342
374930003331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930003332	Walker A motif; other site
374930003333	ATP binding site [chemical binding]; other site
374930003334	Walker B motif; other site
374930003335	arginine finger; other site
374930003336	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
374930003337	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
374930003338	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
374930003339	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
374930003340	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
374930003341	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
374930003342	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
374930003343	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
374930003344	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
374930003345	dimerization interface [polypeptide binding]; other site
374930003346	putative DNA binding site [nucleotide binding]; other site
374930003347	putative Zn2+ binding site [ion binding]; other site
374930003348	AsnC family; Region: AsnC_trans_reg; pfam01037
374930003349	DNA repair protein RadA; Region: sms; TIGR00416
374930003350	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
374930003351	Walker A motif; other site
374930003352	ATP binding site [chemical binding]; other site
374930003353	Walker B motif; other site
374930003354	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
374930003355	Uncharacterized conserved protein [Function unknown]; Region: COG3025
374930003356	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
374930003357	putative active site [active]
374930003358	putative metal binding residues [ion binding]; other site
374930003359	signature motif; other site
374930003360	putative triphosphate binding site [ion binding]; other site
374930003361	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
374930003362	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
374930003363	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
374930003364	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
374930003365	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
374930003366	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
374930003367	Homeodomain-like domain; Region: HTH_23; pfam13384
374930003368	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
374930003369	Mor transcription activator family; Region: Mor; cl02360
374930003370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219
374930003371	Protein of unknown function (DUF692); Region: DUF692; pfam05114
374930003372	Uncharacterized low-complexity protein [Function unknown]; Region: COG3767
374930003373	potential frameshift: common BLAST hit: gi|68249808|ref|YP_248920.1| predicted membrane protein [Haemophilus influenzae 86-028NP]
374930003374	TIGR00153 family protein; Region: TIGR00153
374930003375	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
374930003376	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
374930003377	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
374930003378	Bacterial SH3 domain homologues; Region: SH3b; smart00287
374930003379	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
374930003380	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
374930003381	active site
374930003382	NTP binding site [chemical binding]; other site
374930003383	metal binding triad [ion binding]; metal-binding site
374930003384	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
374930003385	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
374930003386	Zn2+ binding site [ion binding]; other site
374930003387	Mg2+ binding site [ion binding]; other site
374930003388	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
374930003389	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
374930003390	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
374930003391	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
374930003392	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
374930003393	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
374930003394	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
374930003395	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930003396	active site
374930003397	potential frameshift: common BLAST hit: gi|68249800|ref|YP_248912.1| tyrosyl-tRNA synthetase [Haemophilus influenzae 86-028NP]
374930003398	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
374930003399	multidrug efflux protein; Reviewed; Region: PRK01766
374930003400	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
374930003401	cation binding site [ion binding]; other site
374930003402	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
374930003403	Lumazine binding domain; Region: Lum_binding; pfam00677
374930003404	Lumazine binding domain; Region: Lum_binding; pfam00677
374930003405	aminopeptidase N; Provisional; Region: pepN; PRK14015
374930003406	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
374930003407	active site
374930003408	Zn binding site [ion binding]; other site
374930003409	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
374930003410	HicB family; Region: HicB; pfam05534
374930003411	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
374930003412	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
374930003413	ATP-grasp domain; Region: ATP-grasp; pfam02222
374930003414	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
374930003415	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
374930003416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003417	homodimer interface [polypeptide binding]; other site
374930003418	catalytic residue [active]
374930003419	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
374930003420	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
374930003421	Walker A/P-loop; other site
374930003422	ATP binding site [chemical binding]; other site
374930003423	Q-loop/lid; other site
374930003424	ABC transporter signature motif; other site
374930003425	Walker B; other site
374930003426	D-loop; other site
374930003427	H-loop/switch region; other site
374930003428	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
374930003429	cobalt transport protein CbiM; Validated; Region: PRK06265
374930003430	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
374930003431	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
374930003432	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
374930003433	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
374930003434	DNA binding residues [nucleotide binding]
374930003435	dimer interface [polypeptide binding]; other site
374930003436	putative metal binding site [ion binding]; other site
374930003437	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
374930003438	Sel1-like repeats; Region: SEL1; smart00671
374930003439	Sel1-like repeats; Region: SEL1; smart00671
374930003440	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
374930003441	homotrimer interaction site [polypeptide binding]; other site
374930003442	putative active site [active]
374930003443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
374930003444	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
374930003445	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
374930003446	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
374930003447	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
374930003448	5S rRNA interface [nucleotide binding]; other site
374930003449	CTC domain interface [polypeptide binding]; other site
374930003450	L16 interface [polypeptide binding]; other site
374930003451	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
374930003452	substrate binding site [chemical binding]; other site
374930003453	nucleotide binding site [chemical binding]; other site
374930003454	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
374930003455	dimer interface [polypeptide binding]; other site
374930003456	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
374930003457	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
374930003458	GDP-binding site [chemical binding]; other site
374930003459	ACT binding site; other site
374930003460	IMP binding site; other site
374930003461	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
374930003462	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
374930003463	trimer interface [polypeptide binding]; other site
374930003464	active site
374930003465	substrate binding site [chemical binding]; other site
374930003466	CoA binding site [chemical binding]; other site
374930003467	similar to hypothetical protein; COG2171 Tetrahydrodipicolinate N-succinyltransferase
374930003468	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
374930003469	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
374930003470	DNA binding site [nucleotide binding]
374930003471	domain linker motif; other site
374930003472	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
374930003473	dimerization interface [polypeptide binding]; other site
374930003474	ligand binding site [chemical binding]; other site
374930003475	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
374930003476	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
374930003477	putative transposase OrfB; Reviewed; Region: PHA02517
374930003478	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
374930003479	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
374930003480	cofactor binding site; other site
374930003481	DNA binding site [nucleotide binding]
374930003482	substrate interaction site [chemical binding]; other site
374930003483	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
374930003484	HNH endonuclease; Region: HNH_2; pfam13391
374930003485	Predicted ATPase [General function prediction only]; Region: COG3106
374930003486	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
374930003487	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
374930003488	peptide binding site [polypeptide binding]; other site
374930003489	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
374930003490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930003491	dimer interface [polypeptide binding]; other site
374930003492	conserved gate region; other site
374930003493	putative PBP binding loops; other site
374930003494	ABC-ATPase subunit interface; other site
374930003495	potential frameshift: common BLAST hit: gi|68249770|ref|YP_248882.1| ABC-type transport system, permease protein
374930003496	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
374930003497	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
374930003498	Walker A/P-loop; other site
374930003499	ATP binding site [chemical binding]; other site
374930003500	Q-loop/lid; other site
374930003501	ABC transporter signature motif; other site
374930003502	Walker B; other site
374930003503	D-loop; other site
374930003504	H-loop/switch region; other site
374930003505	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
374930003506	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
374930003507	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
374930003508	Walker A/P-loop; other site
374930003509	ATP binding site [chemical binding]; other site
374930003510	Q-loop/lid; other site
374930003511	ABC transporter signature motif; other site
374930003512	Walker B; other site
374930003513	D-loop; other site
374930003514	H-loop/switch region; other site
374930003515	conserved hypothetical integral membrane protein; Region: TIGR00698
374930003516	potential frameshift: common BLAST hit: gi|68249766|ref|YP_248878.1| tRNA pseudouridine synthase A [Haemophilus influenzae 86-028NP]
374930003517	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
374930003518	AMP binding site [chemical binding]; other site
374930003519	metal binding site [ion binding]; metal-binding site
374930003520	active site
374930003521	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
374930003522	active site
374930003523	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
374930003524	L-lactate transport; Region: lctP; TIGR00795
374930003525	potential frameshift: common BLAST hit: gi|16273136|ref|NP_439373.1| transferrin-binding protein [Haemophilus influenzae Rd KW20]
374930003526	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
374930003527	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
374930003528	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
374930003529	catalytic residues [active]
374930003530	hinge region; other site
374930003531	alpha helical domain; other site
374930003532	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
374930003533	Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608
374930003534	DHH family; Region: DHH; pfam01368
374930003535	DHHA1 domain; Region: DHHA1; pfam02272
374930003536	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
374930003537	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
374930003538	dimerization domain [polypeptide binding]; other site
374930003539	dimer interface [polypeptide binding]; other site
374930003540	catalytic residues [active]
374930003541	This domain is found in peptide chain release factors; Region: PCRF; smart00937
374930003542	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
374930003543	RF-1 domain; Region: RF-1; pfam00472
374930003544	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
374930003545	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
374930003546	dimer interface [polypeptide binding]; other site
374930003547	putative anticodon binding site; other site
374930003548	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
374930003549	motif 1; other site
374930003550	active site
374930003551	motif 2; other site
374930003552	motif 3; other site
374930003553	malate dehydrogenase; Provisional; Region: PRK05086
374930003554	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
374930003555	NAD binding site [chemical binding]; other site
374930003556	dimerization interface [polypeptide binding]; other site
374930003557	Substrate binding site [chemical binding]; other site
374930003558	arginine repressor; Provisional; Region: PRK05066
374930003559	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
374930003560	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
374930003561	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
374930003562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930003563	NAD(P) binding site [chemical binding]; other site
374930003564	active site
374930003565	amidophosphoribosyltransferase; Provisional; Region: PRK09246
374930003566	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
374930003567	active site
374930003568	tetramer interface [polypeptide binding]; other site
374930003569	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930003570	active site
374930003571	potential frameshift: common BLAST hit: gi|68249752|ref|YP_248864.1| colicin V production protein [Haemophilus influenzae 86-028NP]
374930003572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3092
374930003573	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
374930003574	propionate/acetate kinase; Provisional; Region: PRK12379
374930003575	phosphate acetyltransferase; Reviewed; Region: PRK05632
374930003576	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
374930003577	DRTGG domain; Region: DRTGG; pfam07085
374930003578	phosphate acetyltransferase; Region: pta; TIGR00651
374930003579	hypothetical protein; Provisional; Region: PRK04946
374930003580	Smr domain; Region: Smr; pfam01713
374930003581	HemK family putative methylases; Region: hemK_fam; TIGR00536
374930003582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930003583	S-adenosylmethionine binding site [chemical binding]; other site
374930003584	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
374930003585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
374930003586	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
374930003587	substrate binding site [chemical binding]; other site
374930003588	dimerization interface [polypeptide binding]; other site
374930003589	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
374930003590	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930003591	RNA binding surface [nucleotide binding]; other site
374930003592	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
374930003593	probable active site [active]
374930003594	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
374930003595	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
374930003596	CoA binding domain; Region: CoA_binding; pfam02629
374930003597	CoA-ligase; Region: Ligase_CoA; pfam00549
374930003598	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
374930003599	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
374930003600	CoA-ligase; Region: Ligase_CoA; pfam00549
374930003601	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
374930003602	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
374930003603	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
374930003604	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
374930003605	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
374930003606	dimerization interface [polypeptide binding]; other site
374930003607	substrate binding pocket [chemical binding]; other site
374930003608	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
374930003609	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
374930003610	homodimer interface [polypeptide binding]; other site
374930003611	substrate-cofactor binding pocket; other site
374930003612	catalytic residue [active]
374930003613	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
374930003614	Ligand Binding Site [chemical binding]; other site
374930003615	6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039
374930003616	active site
374930003617	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
374930003618	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930003619	FeS/SAM binding site; other site
374930003620	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
374930003621	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
374930003622	Part of AAA domain; Region: AAA_19; pfam13245
374930003623	Family description; Region: UvrD_C_2; pfam13538
374930003624	potential frameshift: common BLAST hit: gi|68249733|ref|YP_248845.1| dipeptide transport system permease protein [Haemophilus influenzae]
374930003625	dipeptide transporter; Provisional; Region: PRK10913
374930003626	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
374930003627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930003628	dimer interface [polypeptide binding]; other site
374930003629	conserved gate region; other site
374930003630	putative PBP binding loops; other site
374930003631	ABC-ATPase subunit interface; other site
374930003632	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
374930003633	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
374930003634	Walker A/P-loop; other site
374930003635	ATP binding site [chemical binding]; other site
374930003636	Q-loop/lid; other site
374930003637	ABC transporter signature motif; other site
374930003638	Walker B; other site
374930003639	D-loop; other site
374930003640	H-loop/switch region; other site
374930003641	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
374930003642	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
374930003643	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
374930003644	Walker A/P-loop; other site
374930003645	ATP binding site [chemical binding]; other site
374930003646	Q-loop/lid; other site
374930003647	ABC transporter signature motif; other site
374930003648	Walker B; other site
374930003649	D-loop; other site
374930003650	H-loop/switch region; other site
374930003651	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
374930003652	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
374930003653	active site
374930003654	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
374930003655	DNA binding site [nucleotide binding]
374930003656	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
374930003657	DNA binding site [nucleotide binding]
374930003658	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
374930003659	dimer interface [polypeptide binding]; other site
374930003660	active site
374930003661	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
374930003662	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930003663	Walker A/P-loop; other site
374930003664	ATP binding site [chemical binding]; other site
374930003665	Q-loop/lid; other site
374930003666	ABC transporter signature motif; other site
374930003667	Walker B; other site
374930003668	D-loop; other site
374930003669	H-loop/switch region; other site
374930003670	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
374930003671	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
374930003672	substrate binding pocket [chemical binding]; other site
374930003673	membrane-bound complex binding site; other site
374930003674	hinge residues; other site
374930003675	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
374930003676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930003677	dimer interface [polypeptide binding]; other site
374930003678	conserved gate region; other site
374930003679	putative PBP binding loops; other site
374930003680	ABC-ATPase subunit interface; other site
374930003681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930003682	dimer interface [polypeptide binding]; other site
374930003683	conserved gate region; other site
374930003684	putative PBP binding loops; other site
374930003685	ABC-ATPase subunit interface; other site
374930003686	YadA-like C-terminal region; Region: YadA; pfam03895
374930003687	Opacity family porin protein; Region: Opacity; pfam02462
374930003688	hypothetical protein; Provisional; Region: PRK04860
374930003689	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
374930003690	S-adenosylmethionine synthetase; Validated; Region: PRK05250
374930003691	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
374930003692	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
374930003693	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
374930003694	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
374930003695	Glutamine amidotransferase class-I; Region: GATase; pfam00117
374930003696	glutamine binding [chemical binding]; other site
374930003697	catalytic triad [active]
374930003698	para-aminobenzoate synthase component I; Validated; Region: PRK07093
374930003699	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
374930003700	hypothetical protein; Provisional; Region: PRK07101
374930003701	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
374930003702	substrate-cofactor binding pocket; other site
374930003703	hypothetical protein; Provisional; Region: PRK05423
374930003704	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
374930003705	homodimer interface [polypeptide binding]; other site
374930003706	substrate-cofactor binding pocket; other site
374930003707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003708	catalytic residue [active]
374930003709	potential frameshift: common BLAST hit: gi|68249714|ref|YP_248826.1| putative aminotransferase [Haemophilus influenzae 86-028NP]
374930003710	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
374930003711	putative GSH binding site [chemical binding]; other site
374930003712	catalytic residues [active]
374930003713	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
374930003714	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
374930003715	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
374930003716	ligand binding site [chemical binding]; other site
374930003717	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
374930003718	FAD binding domain; Region: FAD_binding_4; pfam01565
374930003719	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
374930003720	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
374930003721	CoenzymeA binding site [chemical binding]; other site
374930003722	subunit interaction site [polypeptide binding]; other site
374930003723	PHB binding site; other site
374930003724	ferrochelatase; Region: hemH; TIGR00109
374930003725	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
374930003726	C-terminal domain interface [polypeptide binding]; other site
374930003727	active site
374930003728	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
374930003729	active site
374930003730	N-terminal domain interface [polypeptide binding]; other site
374930003731	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
374930003732	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
374930003733	thioredoxin reductase; Provisional; Region: PRK10262
374930003734	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
374930003735	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
374930003736	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
374930003737	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
374930003738	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930003739	Walker A/P-loop; other site
374930003740	ATP binding site [chemical binding]; other site
374930003741	Q-loop/lid; other site
374930003742	ABC transporter signature motif; other site
374930003743	Walker B; other site
374930003744	D-loop; other site
374930003745	H-loop/switch region; other site
374930003746	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
374930003747	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
374930003748	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
374930003749	Walker A/P-loop; other site
374930003750	ATP binding site [chemical binding]; other site
374930003751	Q-loop/lid; other site
374930003752	ABC transporter signature motif; other site
374930003753	Walker B; other site
374930003754	D-loop; other site
374930003755	H-loop/switch region; other site
374930003756	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
374930003757	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930003758	FeS/SAM binding site; other site
374930003759	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
374930003760	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
374930003761	LysE type translocator; Region: LysE; cl00565
374930003762	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930003763	active site
374930003764	peptidase PmbA; Provisional; Region: PRK11040
374930003765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028
374930003766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
374930003767	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
374930003768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
374930003769	OstA-like protein; Region: OstA; cl00844
374930003770	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
374930003771	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
374930003772	Walker A/P-loop; other site
374930003773	ATP binding site [chemical binding]; other site
374930003774	Q-loop/lid; other site
374930003775	ABC transporter signature motif; other site
374930003776	Walker B; other site
374930003777	D-loop; other site
374930003778	H-loop/switch region; other site
374930003779	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
374930003780	active site
374930003781	phosphorylation site [posttranslational modification]
374930003782	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
374930003783	AAA domain; Region: AAA_22; pfam13401
374930003784	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
374930003785	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
374930003786	Prephenate dehydratase; Region: PDT; pfam00800
374930003787	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
374930003788	putative L-Phe binding site [chemical binding]; other site
374930003789	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
374930003790	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
374930003791	cell division protein FtsZ; Validated; Region: PRK09330
374930003792	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
374930003793	nucleotide binding site [chemical binding]; other site
374930003794	SulA interaction site; other site
374930003795	potential frameshift: common BLAST hit: gi|16273068|ref|NP_439300.1| cell division protein [Haemophilus influenzae Rd KW20]
374930003796	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
374930003797	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
374930003798	Cell division protein FtsQ; Region: FtsQ; pfam03799
374930003799	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
374930003800	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
374930003801	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
374930003802	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
374930003803	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
374930003804	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930003805	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930003806	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
374930003807	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
374930003808	active site
374930003809	homodimer interface [polypeptide binding]; other site
374930003810	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
374930003811	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
374930003812	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930003813	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930003814	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
374930003815	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
374930003816	Mg++ binding site [ion binding]; other site
374930003817	putative catalytic motif [active]
374930003818	putative substrate binding site [chemical binding]; other site
374930003819	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
374930003820	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
374930003821	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930003822	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930003823	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
374930003824	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
374930003825	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
374930003826	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
374930003827	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
374930003828	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
374930003829	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
374930003830	Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116
374930003831	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
374930003832	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
374930003833	mraZ protein; Region: TIGR00242
374930003834	MraZ protein; Region: MraZ; pfam02381
374930003835	MraZ protein; Region: MraZ; pfam02381
374930003836	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
374930003837	Carbon starvation protein CstA; Region: CstA; pfam02554
374930003838	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
374930003839	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
374930003840	transaldolase-like protein; Provisional; Region: PTZ00411
374930003841	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
374930003842	active site
374930003843	dimer interface [polypeptide binding]; other site
374930003844	catalytic residue [active]
374930003845	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
374930003846	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
374930003847	peptide binding site [polypeptide binding]; other site
374930003848	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
374930003849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930003850	dimer interface [polypeptide binding]; other site
374930003851	conserved gate region; other site
374930003852	putative PBP binding loops; other site
374930003853	ABC-ATPase subunit interface; other site
374930003854	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
374930003855	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
374930003856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930003857	dimer interface [polypeptide binding]; other site
374930003858	conserved gate region; other site
374930003859	ABC-ATPase subunit interface; other site
374930003860	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
374930003861	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
374930003862	Walker A/P-loop; other site
374930003863	ATP binding site [chemical binding]; other site
374930003864	Q-loop/lid; other site
374930003865	ABC transporter signature motif; other site
374930003866	Walker B; other site
374930003867	D-loop; other site
374930003868	H-loop/switch region; other site
374930003869	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
374930003870	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
374930003871	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
374930003872	Walker A/P-loop; other site
374930003873	ATP binding site [chemical binding]; other site
374930003874	Q-loop/lid; other site
374930003875	ABC transporter signature motif; other site
374930003876	Walker B; other site
374930003877	D-loop; other site
374930003878	H-loop/switch region; other site
374930003879	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
374930003880	potential frameshift: common BLAST hit: gi|68249670|ref|YP_248782.1| D-xylose transport permease protein [Haemophilus influenzae]
374930003881	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
374930003882	G1 box; other site
374930003883	GTP/Mg2+ binding site [chemical binding]; other site
374930003884	Switch I region; other site
374930003885	G2 box; other site
374930003886	G3 box; other site
374930003887	Switch II region; other site
374930003888	G4 box; other site
374930003889	G5 box; other site
374930003890	Mg chelatase-related protein; Region: TIGR00368
374930003891	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
374930003892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930003893	Walker A motif; other site
374930003894	ATP binding site [chemical binding]; other site
374930003895	Walker B motif; other site
374930003896	arginine finger; other site
374930003897	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
374930003898	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
374930003899	intersubunit interface [polypeptide binding]; other site
374930003900	active site
374930003901	catalytic residue [active]
374930003902	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
374930003903	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
374930003904	catalytic residues [active]
374930003905	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
374930003906	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
374930003907	NADP binding site [chemical binding]; other site
374930003908	homopentamer interface [polypeptide binding]; other site
374930003909	substrate binding site [chemical binding]; other site
374930003910	active site
374930003911	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
374930003912	active site
374930003913	xylulose binding site [chemical binding]; other site
374930003914	N- and C-terminal domain interface [polypeptide binding]; other site
374930003915	MgATP binding site [chemical binding]; other site
374930003916	putative homodimer interface [polypeptide binding]; other site
374930003917	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
374930003918	nucleotide binding site [chemical binding]; other site
374930003919	xylose isomerase; Provisional; Region: PRK05474
374930003920	xylose isomerase; Region: xylose_isom_A; TIGR02630
374930003921	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
374930003922	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
374930003923	putative ligand binding site [chemical binding]; other site
374930003924	potential frameshift: common BLAST hit: gi|16273035|ref|NP_439267.1| D-xylose ABC transporter ATP-binding protein [Haemophilus]
374930003925	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
374930003926	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930003927	TM-ABC transporter signature motif; other site
374930003928	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
374930003929	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
374930003930	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003931	homodimer interface [polypeptide binding]; other site
374930003932	catalytic residue [active]
374930003933	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
374930003934	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
374930003935	putative dimerization interface [polypeptide binding]; other site
374930003936	Transcriptional regulators [Transcription]; Region: PurR; COG1609
374930003937	putative ligand binding site [chemical binding]; other site
374930003938	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
374930003939	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
374930003940	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
374930003941	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
374930003942	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
374930003943	putative active site [active]
374930003944	benzoate transport; Region: 2A0115; TIGR00895
374930003945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930003946	putative substrate translocation pore; other site
374930003947	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
374930003948	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
374930003949	dimer interface [polypeptide binding]; other site
374930003950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930003951	catalytic residue [active]
374930003952	putative sulfate transport protein CysZ; Validated; Region: PRK04949
374930003953	cell division protein ZipA; Provisional; Region: PRK01741
374930003954	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
374930003955	FtsZ protein binding site [polypeptide binding]; other site
374930003956	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
374930003957	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
374930003958	nucleotide binding pocket [chemical binding]; other site
374930003959	K-X-D-G motif; other site
374930003960	catalytic site [active]
374930003961	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
374930003962	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
374930003963	Helix-hairpin-helix motif; Region: HHH; pfam00633
374930003964	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
374930003965	Dimer interface [polypeptide binding]; other site
374930003966	BRCT sequence motif; other site
374930003967	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
374930003968	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
374930003969	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
374930003970	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
374930003971	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
374930003972	TPR motif; other site
374930003973	binding surface
374930003974	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
374930003975	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
374930003976	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
374930003977	catalytic residues [active]
374930003978	central insert; other site
374930003979	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
374930003980	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
374930003981	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
374930003982	heme exporter protein CcmC; Region: ccmC; TIGR01191
374930003983	heme exporter protein CcmB; Region: ccmB; TIGR01190
374930003984	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
374930003985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930003986	Walker A/P-loop; other site
374930003987	ATP binding site [chemical binding]; other site
374930003988	Q-loop/lid; other site
374930003989	ABC transporter signature motif; other site
374930003990	Walker B; other site
374930003991	D-loop; other site
374930003992	H-loop/switch region; other site
374930003993	superoxide dismutase; Provisional; Region: PRK10925
374930003994	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
374930003995	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
374930003996	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
374930003997	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
374930003998	Walker A/P-loop; other site
374930003999	ATP binding site [chemical binding]; other site
374930004000	Q-loop/lid; other site
374930004001	ABC transporter signature motif; other site
374930004002	Walker B; other site
374930004003	D-loop; other site
374930004004	H-loop/switch region; other site
374930004005	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
374930004006	conserved hypothetical integral membrane protein; Region: TIGR00056
374930004007	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
374930004008	mce related protein; Region: MCE; pfam02470
374930004009	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854
374930004010	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
374930004011	anti sigma factor interaction site; other site
374930004012	regulatory phosphorylation site [posttranslational modification]; other site
374930004013	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
374930004014	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
374930004015	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
374930004016	hinge; other site
374930004017	active site
374930004018	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
374930004019	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
374930004020	substrate binding pocket [chemical binding]; other site
374930004021	membrane-bound complex binding site; other site
374930004022	hinge residues; other site
374930004023	potential frameshift: common BLAST hit: gi|16273641|ref|NP_439236.1| ABC-type amino acid transport system permease component
374930004024	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
374930004025	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
374930004026	Walker A/P-loop; other site
374930004027	ATP binding site [chemical binding]; other site
374930004028	Q-loop/lid; other site
374930004029	ABC transporter signature motif; other site
374930004030	Walker B; other site
374930004031	D-loop; other site
374930004032	H-loop/switch region; other site
374930004033	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
374930004034	CTP synthetase; Validated; Region: pyrG; PRK05380
374930004035	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
374930004036	Catalytic site [active]
374930004037	active site
374930004038	UTP binding site [chemical binding]; other site
374930004039	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
374930004040	active site
374930004041	putative oxyanion hole; other site
374930004042	catalytic triad [active]
374930004043	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
374930004044	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
374930004045	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
374930004046	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
374930004047	Predicted membrane protein [Function unknown]; Region: COG2707
374930004048	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
374930004049	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
374930004050	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930004051	ATP binding site [chemical binding]; other site
374930004052	putative Mg++ binding site [ion binding]; other site
374930004053	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930004054	nucleotide binding region [chemical binding]; other site
374930004055	ATP-binding site [chemical binding]; other site
374930004056	Helicase associated domain (HA2); Region: HA2; pfam04408
374930004057	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
374930004058	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
374930004059	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
374930004060	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
374930004061	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
374930004062	potential frameshift: common BLAST hit: gi|68249624|ref|YP_248736.1| NrfD, formate-dependent nitrite reductase, membrane component
374930004063	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
374930004064	putative nucleotide binding site [chemical binding]; other site
374930004065	uridine monophosphate binding site [chemical binding]; other site
374930004066	homohexameric interface [polypeptide binding]; other site
374930004067	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
374930004068	Sulfatase; Region: Sulfatase; pfam00884
374930004069	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
374930004070	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
374930004071	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
374930004072	active site
374930004073	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
374930004074	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
374930004075	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
374930004076	RNA/DNA hybrid binding site [nucleotide binding]; other site
374930004077	active site
374930004078	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
374930004079	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
374930004080	DNA methylase; Region: N6_N4_Mtase; pfam01555
374930004081	DNA methylase; Region: N6_N4_Mtase; pfam01555
374930004082	potential frameshift: common BLAST hit: gi|59801067|ref|YP_207779.1| RmsR [Neisseria gonorrhoeae FA 1090]
374930004083	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
374930004084	Cupin; Region: Cupin_6; pfam12852
374930004085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
374930004086	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
374930004087	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
374930004088	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
374930004089	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
374930004090	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
374930004091	Walker A/P-loop; other site
374930004092	ATP binding site [chemical binding]; other site
374930004093	Q-loop/lid; other site
374930004094	ABC transporter signature motif; other site
374930004095	Walker B; other site
374930004096	D-loop; other site
374930004097	H-loop/switch region; other site
374930004098	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
374930004099	metal-binding site [ion binding]
374930004100	MerT mercuric transport protein; Region: MerT; cl03578
374930004101	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
374930004102	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
374930004103	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
374930004104	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
374930004105	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
374930004106	putative [Fe4-S4] binding site [ion binding]; other site
374930004107	putative molybdopterin cofactor binding site [chemical binding]; other site
374930004108	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
374930004109	molybdopterin cofactor binding site; other site
374930004110	potential frameshift: common BLAST hit: gi|68249608|ref|YP_248720.1| anaerobic dimethyl sulfoxide reductase chain B [Haemophilus]
374930004111	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
374930004112	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
374930004113	ferredoxin-type protein NapF; Region: napF; TIGR00402
374930004114	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
374930004115	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
374930004116	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
374930004117	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
374930004118	putative active site [active]
374930004119	putative dimer interface [polypeptide binding]; other site
374930004120	YGGT family; Region: YGGT; pfam02325
374930004121	YGGT family; Region: YGGT; pfam02325
374930004122	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
374930004123	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
374930004124	Cl binding site [ion binding]; other site
374930004125	oligomer interface [polypeptide binding]; other site
374930004126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
374930004127	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
374930004128	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
374930004129	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
374930004130	motif II; other site
374930004131	transketolase; Reviewed; Region: PRK12753
374930004132	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
374930004133	TPP-binding site [chemical binding]; other site
374930004134	dimer interface [polypeptide binding]; other site
374930004135	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
374930004136	PYR/PP interface [polypeptide binding]; other site
374930004137	dimer interface [polypeptide binding]; other site
374930004138	TPP binding site [chemical binding]; other site
374930004139	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
374930004140	biotin synthase; Region: bioB; TIGR00433
374930004141	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930004142	FeS/SAM binding site; other site
374930004143	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
374930004144	potential frameshift: common BLAST hit: gi|68249594|ref|YP_248706.1| thiamine transport ATP-binding protein [Haemophilus influenzae]
374930004145	thiamine ABC transporter, permease protein; Region: thiP; TIGR01253
374930004146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930004147	dimer interface [polypeptide binding]; other site
374930004148	conserved gate region; other site
374930004149	putative PBP binding loops; other site
374930004150	ABC-ATPase subunit interface; other site
374930004151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
374930004152	dimer interface [polypeptide binding]; other site
374930004153	conserved gate region; other site
374930004154	putative PBP binding loops; other site
374930004155	ABC-ATPase subunit interface; other site
374930004156	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
374930004157	thiamine ABC transporter, periplasmic binding protein; Region: thiB; TIGR01276
374930004158	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
374930004159	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
374930004160	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
374930004161	potential frameshift: common BLAST hit: gi|16272941|ref|NP_439167.1| signal peptidase II [Haemophilus influenzae Rd KW20]
374930004162	potential frameshift: common BLAST hit: gi|68249588|ref|YP_248700.1| predicted PE--lipooligosaccharide phosphorylethanolamine
374930004163	periplasmic folding chaperone; Provisional; Region: PRK10788
374930004164	SurA N-terminal domain; Region: SurA_N_3; cl07813
374930004165	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
374930004166	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
374930004167	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
374930004168	trmE is a tRNA modification GTPase; Region: trmE; cd04164
374930004169	G1 box; other site
374930004170	GTP/Mg2+ binding site [chemical binding]; other site
374930004171	Switch I region; other site
374930004172	G2 box; other site
374930004173	Switch II region; other site
374930004174	G3 box; other site
374930004175	G4 box; other site
374930004176	G5 box; other site
374930004177	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
374930004178	membrane protein insertase; Provisional; Region: PRK01318
374930004179	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
374930004180	ribonuclease P; Reviewed; Region: rnpA; PRK01732
374930004181	hypothetical protein; Validated; Region: PRK00041
374930004182	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
374930004183	Protein of unknown function (DUF560); Region: DUF560; pfam04575
374930004184	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
374930004185	TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776
374930004186	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
374930004187	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930004188	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
374930004189	DnaA N-terminal domain; Region: DnaA_N; pfam11638
374930004190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930004191	Walker A motif; other site
374930004192	ATP binding site [chemical binding]; other site
374930004193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
374930004194	Walker B motif; other site
374930004195	arginine finger; other site
374930004196	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
374930004197	DnaA box-binding interface [nucleotide binding]; other site
374930004198	DNA polymerase III subunit beta; Validated; Region: PRK05643
374930004199	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
374930004200	putative DNA binding surface [nucleotide binding]; other site
374930004201	dimer interface [polypeptide binding]; other site
374930004202	beta-clamp/clamp loader binding surface; other site
374930004203	beta-clamp/translesion DNA polymerase binding surface; other site
374930004204	recF protein; Region: recf; TIGR00611
374930004205	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930004206	Walker A/P-loop; other site
374930004207	ATP binding site [chemical binding]; other site
374930004208	Q-loop/lid; other site
374930004209	ABC transporter signature motif; other site
374930004210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930004211	ABC transporter signature motif; other site
374930004212	Walker B; other site
374930004213	D-loop; other site
374930004214	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
374930004215	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
374930004216	Sporulation related domain; Region: SPOR; cl10051
374930004217	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
374930004218	Autotransporter beta-domain; Region: Autotransporter; pfam03797
374930004219	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
374930004220	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
374930004221	substrate binding site [chemical binding]; other site
374930004222	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
374930004223	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
374930004224	substrate binding site [chemical binding]; other site
374930004225	ligand binding site [chemical binding]; other site
374930004226	tartrate dehydrogenase; Region: TTC; TIGR02089
374930004227	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
374930004228	2-isopropylmalate synthase; Validated; Region: PRK00915
374930004229	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
374930004230	active site
374930004231	catalytic residues [active]
374930004232	metal binding site [ion binding]; metal-binding site
374930004233	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
374930004234	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
374930004235	DNA protecting protein DprA; Region: dprA; TIGR00732
374930004236	hypothetical protein; Validated; Region: PRK02101
374930004237	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
374930004238	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
374930004239	active site
374930004240	ADP/pyrophosphate binding site [chemical binding]; other site
374930004241	dimerization interface [polypeptide binding]; other site
374930004242	allosteric effector site; other site
374930004243	fructose-1,6-bisphosphate binding site; other site
374930004244	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
374930004245	SmpB-tmRNA interface; other site
374930004246	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
374930004247	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
374930004248	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
374930004249	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
374930004250	FMN binding site [chemical binding]; other site
374930004251	active site
374930004252	catalytic residues [active]
374930004253	substrate binding site [chemical binding]; other site
374930004254	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
374930004255	Methyltransferase domain; Region: Methyltransf_18; pfam12847
374930004256	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
374930004257	Fic/DOC family; Region: Fic; cl00960
374930004258	EamA-like transporter family; Region: EamA; pfam00892
374930004259	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
374930004260	EamA-like transporter family; Region: EamA; pfam00892
374930004261	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
374930004262	Na binding site [ion binding]; other site
374930004263	Predicted membrane protein [Function unknown]; Region: COG3924
374930004264	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
374930004265	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
374930004266	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
374930004267	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
374930004268	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
374930004269	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
374930004270	carboxyltransferase (CT) interaction site; other site
374930004271	biotinylation site [posttranslational modification]; other site
374930004272	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
374930004273	Dehydroquinase class II; Region: DHquinase_II; pfam01220
374930004274	active site
374930004275	trimer interface [polypeptide binding]; other site
374930004276	dimer interface [polypeptide binding]; other site
374930004277	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
374930004278	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
374930004279	active site
374930004280	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
374930004281	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
374930004282	substrate binding site [chemical binding]; other site
374930004283	oxyanion hole (OAH) forming residues; other site
374930004284	trimer interface [polypeptide binding]; other site
374930004285	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
374930004286	potential frameshift: common BLAST hit: gi|68249552|ref|YP_248664.1| putative virulence factor MviN [Haemophilus influenzae 86-028NP]
374930004287	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
374930004288	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
374930004289	active site
374930004290	Riboflavin kinase; Region: Flavokinase; smart00904
374930004291	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
374930004292	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
374930004293	active site
374930004294	HIGH motif; other site
374930004295	nucleotide binding site [chemical binding]; other site
374930004296	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
374930004297	active site
374930004298	KMSKS motif; other site
374930004299	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
374930004300	tRNA binding surface [nucleotide binding]; other site
374930004301	anticodon binding site; other site
374930004302	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
374930004303	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
374930004304	nucleotide binding site/active site [active]
374930004305	HIT family signature motif; other site
374930004306	catalytic residue [active]
374930004307	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
374930004308	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
374930004309	putative dimer interface [polypeptide binding]; other site
374930004310	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
374930004311	beta-hexosaminidase; Provisional; Region: PRK05337
374930004312	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
374930004313	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
374930004314	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
374930004315	ligand binding site [chemical binding]; other site
374930004316	flexible hinge region; other site
374930004317	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
374930004318	putative switch regulator; other site
374930004319	non-specific DNA interactions [nucleotide binding]; other site
374930004320	DNA binding site [nucleotide binding]
374930004321	sequence specific DNA binding site [nucleotide binding]; other site
374930004322	putative cAMP binding site [chemical binding]; other site
374930004323	hypothetical protein; Provisional; Region: PRK04966
374930004324	division inhibitor protein; Provisional; Region: slmA; PRK09480
374930004325	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
374930004326	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
374930004327	trimer interface [polypeptide binding]; other site
374930004328	active site
374930004329	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
374930004330	Flavoprotein; Region: Flavoprotein; pfam02441
374930004331	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
374930004332	hypothetical protein; Reviewed; Region: PRK00024
374930004333	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
374930004334	MPN+ (JAMM) motif; other site
374930004335	Zinc-binding site [ion binding]; other site
374930004336	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
374930004337	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
374930004338	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
374930004339	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
374930004340	inhibitor-cofactor binding pocket; inhibition site
374930004341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930004342	catalytic residue [active]
374930004343	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
374930004344	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
374930004345	oligomeric interface; other site
374930004346	putative active site [active]
374930004347	homodimer interface [polypeptide binding]; other site
374930004348	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
374930004349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930004350	catalytic residue [active]
374930004351	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
374930004352	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
374930004353	DNA binding site [nucleotide binding]
374930004354	catalytic residue [active]
374930004355	H2TH interface [polypeptide binding]; other site
374930004356	putative catalytic residues [active]
374930004357	turnover-facilitating residue; other site
374930004358	intercalation triad [nucleotide binding]; other site
374930004359	8OG recognition residue [nucleotide binding]; other site
374930004360	putative reading head residues; other site
374930004361	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
374930004362	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
374930004363	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
374930004364	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
374930004365	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
374930004366	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
374930004367	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
374930004368	catalytic motif [active]
374930004369	Zn binding site [ion binding]; other site
374930004370	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
374930004371	transcriptional regulator NrdR; Region: TIGR00244
374930004372	ATP cone domain; Region: ATP-cone; pfam03477
374930004373	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
374930004374	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
374930004375	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
374930004376	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
374930004377	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
374930004378	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
374930004379	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
374930004380	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
374930004381	active site
374930004382	dimerization interface [polypeptide binding]; other site
374930004383	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
374930004384	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
374930004385	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
374930004386	catalytic residues [active]
374930004387	central insert; other site
374930004388	cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147
374930004389	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
374930004390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
374930004391	binding surface
374930004392	TPR motif; other site
374930004393	enolase; Provisional; Region: eno; PRK00077
374930004394	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
374930004395	dimer interface [polypeptide binding]; other site
374930004396	metal binding site [ion binding]; metal-binding site
374930004397	substrate binding pocket [chemical binding]; other site
374930004398	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
374930004399	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
374930004400	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
374930004401	tetramer interface [polypeptide binding]; other site
374930004402	heme binding pocket [chemical binding]; other site
374930004403	NADPH binding site [chemical binding]; other site
374930004404	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
374930004405	dimer interface [polypeptide binding]; other site
374930004406	motif 1; other site
374930004407	active site
374930004408	motif 2; other site
374930004409	motif 3; other site
374930004410	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
374930004411	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
374930004412	putative active site [active]
374930004413	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
374930004414	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
374930004415	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
374930004416	primosomal protein DnaI; Provisional; Region: PRK02854
374930004417	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
374930004418	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
374930004419	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
374930004420	Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980
374930004421	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
374930004422	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
374930004423	HIGH motif; other site
374930004424	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
374930004425	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
374930004426	active site
374930004427	KMSKS motif; other site
374930004428	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
374930004429	tRNA binding surface [nucleotide binding]; other site
374930004430	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
374930004431	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
374930004432	catalytic residue [active]
374930004433	putative FPP diphosphate  binding site; other site
374930004434	putative FPP binding hydrophobic cleft; other site
374930004435	dimer interface [polypeptide binding]; other site
374930004436	putative IPP diphosphate binding site; other site
374930004437	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
374930004438	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
374930004439	zinc metallopeptidase RseP; Provisional; Region: PRK10779
374930004440	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
374930004441	active site
374930004442	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
374930004443	protein binding site [polypeptide binding]; other site
374930004444	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
374930004445	protein binding site [polypeptide binding]; other site
374930004446	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
374930004447	putative substrate binding region [chemical binding]; other site
374930004448	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
374930004449	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
374930004450	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
374930004451	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
374930004452	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
374930004453	Surface antigen; Region: Bac_surface_Ag; pfam01103
374930004454	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
374930004455	periplasmic chaperone; Provisional; Region: PRK10780
374930004456	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
374930004457	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
374930004458	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
374930004459	trimer interface [polypeptide binding]; other site
374930004460	active site
374930004461	UDP-GlcNAc binding site [chemical binding]; other site
374930004462	lipid binding site [chemical binding]; lipid-binding site
374930004463	elongation factor Ts; Provisional; Region: tsf; PRK09377
374930004464	UBA/TS-N domain; Region: UBA; pfam00627
374930004465	Elongation factor TS; Region: EF_TS; pfam00889
374930004466	Elongation factor TS; Region: EF_TS; pfam00889
374930004467	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
374930004468	rRNA interaction site [nucleotide binding]; other site
374930004469	S8 interaction site; other site
374930004470	putative laminin-1 binding site; other site
374930004471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930004472	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
374930004473	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
374930004474	TrkA-N domain; Region: TrkA_N; pfam02254
374930004475	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
374930004476	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
374930004477	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
374930004478	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
374930004479	nucleotide binding region [chemical binding]; other site
374930004480	ATP-binding site [chemical binding]; other site
374930004481	SEC-C motif; Region: SEC-C; pfam02810
374930004482	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
374930004483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701
374930004484	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
374930004485	nucleoside/Zn binding site; other site
374930004486	dimer interface [polypeptide binding]; other site
374930004487	catalytic motif [active]
374930004488	thymidylate synthase; Reviewed; Region: thyA; PRK01827
374930004489	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
374930004490	dimerization interface [polypeptide binding]; other site
374930004491	active site
374930004492	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
374930004493	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
374930004494	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
374930004495	putative active site [active]
374930004496	Ap4A binding site [chemical binding]; other site
374930004497	nudix motif; other site
374930004498	putative metal binding site [ion binding]; other site
374930004499	gamma-glutamyl kinase; Provisional; Region: PRK05429
374930004500	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
374930004501	nucleotide binding site [chemical binding]; other site
374930004502	homotetrameric interface [polypeptide binding]; other site
374930004503	putative phosphate binding site [ion binding]; other site
374930004504	putative allosteric binding site; other site
374930004505	PUA domain; Region: PUA; pfam01472
374930004506	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
374930004507	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
374930004508	folate binding site [chemical binding]; other site
374930004509	NADP+ binding site [chemical binding]; other site
374930004510	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
374930004511	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
374930004512	HlyD family secretion protein; Region: HlyD_3; pfam13437
374930004513	potential frameshift: common BLAST hit: gi|68249484|ref|YP_248596.1| multidrug resistance protein [Haemophilus influenzae 86-028NP]
374930004514	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
374930004515	Sporulation related domain; Region: SPOR; pfam05036
374930004516	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
374930004517	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
374930004518	HlyD family secretion protein; Region: HlyD_3; pfam13437
374930004519	potential frameshift: common BLAST hit: gi|16272831|ref|NP_439054.1| transcriptional repressor [Haemophilus influenzae Rd KW20]
374930004520	similar to hypothetical protein; COG1309 Transcriptional regulator
374930004521	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
374930004522	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
374930004523	ATP binding site [chemical binding]; other site
374930004524	Mg++ binding site [ion binding]; other site
374930004525	motif III; other site
374930004526	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930004527	nucleotide binding region [chemical binding]; other site
374930004528	ATP-binding site [chemical binding]; other site
374930004529	DNA gyrase inhibitor; Reviewed; Region: PRK00418
374930004530	dephospho-CoA kinase; Region: TIGR00152
374930004531	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
374930004532	CoA-binding site [chemical binding]; other site
374930004533	ATP-binding [chemical binding]; other site
374930004534	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
374930004535	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
374930004536	dimer interface [polypeptide binding]; other site
374930004537	active site
374930004538	glycine-pyridoxal phosphate binding site [chemical binding]; other site
374930004539	folate binding site [chemical binding]; other site
374930004540	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
374930004541	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
374930004542	active site
374930004543	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
374930004544	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
374930004545	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
374930004546	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
374930004547	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
374930004548	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
374930004549	purine monophosphate binding site [chemical binding]; other site
374930004550	dimer interface [polypeptide binding]; other site
374930004551	putative catalytic residues [active]
374930004552	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
374930004553	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
374930004554	Predicted membrane protein [Function unknown]; Region: COG2259
374930004555	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
374930004556	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
374930004557	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
374930004558	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
374930004559	DsbD alpha interface [polypeptide binding]; other site
374930004560	catalytic residues [active]
374930004561	two-component response regulator; Provisional; Region: PRK11173
374930004562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
374930004563	active site
374930004564	phosphorylation site [posttranslational modification]
374930004565	intermolecular recognition site; other site
374930004566	dimerization interface [polypeptide binding]; other site
374930004567	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
374930004568	DNA binding site [nucleotide binding]
374930004569	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
374930004570	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
374930004571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
374930004572	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
374930004573	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
374930004574	substrate binding pocket [chemical binding]; other site
374930004575	chain length determination region; other site
374930004576	substrate-Mg2+ binding site; other site
374930004577	catalytic residues [active]
374930004578	aspartate-rich region 1; other site
374930004579	active site lid residues [active]
374930004580	aspartate-rich region 2; other site
374930004581	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
374930004582	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
374930004583	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
374930004584	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
374930004585	EamA-like transporter family; Region: EamA; pfam00892
374930004586	EamA-like transporter family; Region: EamA; pfam00892
374930004587	GTPase CgtA; Reviewed; Region: obgE; PRK12298
374930004588	GTP1/OBG; Region: GTP1_OBG; pfam01018
374930004589	Obg GTPase; Region: Obg; cd01898
374930004590	G1 box; other site
374930004591	GTP/Mg2+ binding site [chemical binding]; other site
374930004592	Switch I region; other site
374930004593	G2 box; other site
374930004594	G3 box; other site
374930004595	Switch II region; other site
374930004596	G4 box; other site
374930004597	G5 box; other site
374930004598	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
374930004599	active site
374930004600	multimer interface [polypeptide binding]; other site
374930004601	aminopeptidase B; Provisional; Region: PRK05015
374930004602	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
374930004603	interface (dimer of trimers) [polypeptide binding]; other site
374930004604	Substrate-binding/catalytic site; other site
374930004605	Zn-binding sites [ion binding]; other site
374930004606	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
374930004607	O-Antigen ligase; Region: Wzy_C; pfam04932
374930004608	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
374930004609	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
374930004610	NAD binding site [chemical binding]; other site
374930004611	substrate binding site [chemical binding]; other site
374930004612	homodimer interface [polypeptide binding]; other site
374930004613	active site
374930004614	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
374930004615	Bacterial sugar transferase; Region: Bac_transf; pfam02397
374930004616	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
374930004617	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
374930004618	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
374930004619	active site
374930004620	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
374930004621	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
374930004622	active site
374930004623	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
374930004624	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
374930004625	potential frameshift: common BLAST hit: gi|68249460|ref|YP_248572.1| glutamine synthetase [Haemophilus influenzae 86-028NP]
374930004626	Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002
374930004627	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
374930004628	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
374930004629	G1 box; other site
374930004630	putative GEF interaction site [polypeptide binding]; other site
374930004631	GTP/Mg2+ binding site [chemical binding]; other site
374930004632	Switch I region; other site
374930004633	G2 box; other site
374930004634	G3 box; other site
374930004635	Switch II region; other site
374930004636	G4 box; other site
374930004637	G5 box; other site
374930004638	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
374930004639	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
374930004640	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
374930004641	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
374930004642	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
374930004643	hypothetical protein; Provisional; Region: PRK11212
374930004644	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
374930004645	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
374930004646	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
374930004647	RNB domain; Region: RNB; pfam00773
374930004648	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
374930004649	RNA binding site [nucleotide binding]; other site
374930004650	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
374930004651	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
374930004652	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
374930004653	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
374930004654	Clp amino terminal domain; Region: Clp_N; pfam02861
374930004655	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930004656	Walker A motif; other site
374930004657	ATP binding site [chemical binding]; other site
374930004658	Walker B motif; other site
374930004659	arginine finger; other site
374930004660	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930004661	Walker A motif; other site
374930004662	ATP binding site [chemical binding]; other site
374930004663	Walker B motif; other site
374930004664	arginine finger; other site
374930004665	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
374930004666	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
374930004667	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
374930004668	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
374930004669	DNA polymerase I; Provisional; Region: PRK05755
374930004670	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
374930004671	active site
374930004672	metal binding site 1 [ion binding]; metal-binding site
374930004673	putative 5' ssDNA interaction site; other site
374930004674	metal binding site 3; metal-binding site
374930004675	metal binding site 2 [ion binding]; metal-binding site
374930004676	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
374930004677	putative DNA binding site [nucleotide binding]; other site
374930004678	putative metal binding site [ion binding]; other site
374930004679	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
374930004680	active site
374930004681	catalytic site [active]
374930004682	substrate binding site [chemical binding]; other site
374930004683	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
374930004684	active site
374930004685	DNA binding site [nucleotide binding]
374930004686	catalytic site [active]
374930004687	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
374930004688	heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109
374930004689	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
374930004690	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
374930004691	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
374930004692	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
374930004693	peptide binding site [polypeptide binding]; other site
374930004694	potential frameshift: common BLAST hit: gi|52426109|ref|YP_089246.1| ProP protein [Mannheimia succiniciproducens MBEL55E]
374930004695	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
374930004696	Walker A motif; other site
374930004697	similar to hypothetical protein; COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein
374930004698	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
374930004699	Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445
374930004700	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
374930004701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930004702	S-adenosylmethionine binding site [chemical binding]; other site
374930004703	hypothetical protein; Provisional; Region: PRK11027
374930004704	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
374930004705	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
374930004706	catalytic residues [active]
374930004707	hinge region; other site
374930004708	alpha helical domain; other site
374930004709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084
374930004710	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
374930004711	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
374930004712	GTP binding site; other site
374930004713	hypothetical protein; Validated; Region: PRK06886
374930004714	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
374930004715	active site
374930004716	potential frameshift: common BLAST hit: gi|68249436|ref|YP_248548.1| predicted hydrolase of alkaline phosphatase superfamily
374930004717	hypothetical protein; Provisional; Region: PRK13689
374930004718	Nucleoid-associated protein [General function prediction only]; Region: COG3081
374930004719	nucleoid-associated protein NdpA; Validated; Region: PRK00378
374930004720	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
374930004721	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
374930004722	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
374930004723	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
374930004724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
374930004725	active site
374930004726	phosphorylation site [posttranslational modification]
374930004727	intermolecular recognition site; other site
374930004728	dimerization interface [polypeptide binding]; other site
374930004729	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
374930004730	DNA binding site [nucleotide binding]
374930004731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
374930004732	G-X-G motif; other site
374930004733	two-component sensor protein; Provisional; Region: cpxA; PRK09470
374930004734	poxB regulator PoxA; Provisional; Region: PRK09350
374930004735	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
374930004736	motif 1; other site
374930004737	dimer interface [polypeptide binding]; other site
374930004738	active site
374930004739	motif 2; other site
374930004740	motif 3; other site
374930004741	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
374930004742	L-aspartate oxidase; Provisional; Region: PRK06175
374930004743	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
374930004744	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
374930004745	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
374930004746	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
374930004747	D-subunit interface [polypeptide binding]; other site
374930004748	Iron-sulfur protein interface; other site
374930004749	proximal quinone binding site [chemical binding]; other site
374930004750	distal quinone binding site [chemical binding]; other site
374930004751	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
374930004752	Iron-sulfur protein interface; other site
374930004753	proximal quinone binding site [chemical binding]; other site
374930004754	C-subunit interface; other site
374930004755	distal quinone binding site; other site
374930004756	Transglycosylase; Region: Transgly; cl17702
374930004757	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
374930004758	Trp operon repressor; Provisional; Region: PRK01381
374930004759	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
374930004760	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
374930004761	N-acetyl-D-glucosamine binding site [chemical binding]; other site
374930004762	catalytic residue [active]
374930004763	YciI-like protein; Reviewed; Region: PRK11370
374930004764	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
374930004765	Intracellular septation protein A [Cell division and chromosome partitioning]; Region: COG2917
374930004766	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
374930004767	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930004768	TM-ABC transporter signature motif; other site
374930004769	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
374930004770	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
374930004771	Walker A/P-loop; other site
374930004772	ATP binding site [chemical binding]; other site
374930004773	Q-loop/lid; other site
374930004774	ABC transporter signature motif; other site
374930004775	Walker B; other site
374930004776	D-loop; other site
374930004777	H-loop/switch region; other site
374930004778	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
374930004779	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
374930004780	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
374930004781	ligand binding site [chemical binding]; other site
374930004782	calcium binding site [ion binding]; other site
374930004783	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
374930004784	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
374930004785	DNA binding site [nucleotide binding]
374930004786	domain linker motif; other site
374930004787	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
374930004788	ligand binding site [chemical binding]; other site
374930004789	dimerization interface (closed form) [polypeptide binding]; other site
374930004790	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
374930004791	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
374930004792	dimer interface [polypeptide binding]; other site
374930004793	active site
374930004794	galactokinase; Provisional; Region: PRK05101
374930004795	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
374930004796	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
374930004797	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
374930004798	active site
374930004799	catalytic residues [active]
374930004800	hypothetical protein; Reviewed; Region: PRK01736
374930004801	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
374930004802	proline aminopeptidase P II; Provisional; Region: PRK10879
374930004803	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
374930004804	active site
374930004805	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
374930004806	Ligand Binding Site [chemical binding]; other site
374930004807	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
374930004808	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
374930004809	motif 1; other site
374930004810	active site
374930004811	motif 2; other site
374930004812	motif 3; other site
374930004813	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
374930004814	DHHA1 domain; Region: DHHA1; pfam02272
374930004815	carbon storage regulator; Provisional; Region: PRK01712
374930004816	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
374930004817	active site
374930004818	tetramer interface; other site
374930004819	argininosuccinate lyase; Provisional; Region: PRK04833
374930004820	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
374930004821	active sites [active]
374930004822	tetramer interface [polypeptide binding]; other site
374930004823	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
374930004824	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
374930004825	dimerization interface [polypeptide binding]; other site
374930004826	domain crossover interface; other site
374930004827	redox-dependent activation switch; other site
374930004828	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
374930004829	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
374930004830	active site
374930004831	substrate-binding site [chemical binding]; other site
374930004832	metal-binding site [ion binding]
374930004833	ATP binding site [chemical binding]; other site
374930004834	ribosome recycling factor; Reviewed; Region: frr; PRK00083
374930004835	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
374930004836	hinge region; other site
374930004837	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
374930004838	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
374930004839	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
374930004840	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
374930004841	Predicted permeases [General function prediction only]; Region: COG0730
374930004842	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
374930004843	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
374930004844	FeS/SAM binding site; other site
374930004845	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
374930004846	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
374930004847	putative switch regulator; other site
374930004848	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
374930004849	non-specific DNA interactions [nucleotide binding]; other site
374930004850	DNA binding site [nucleotide binding]
374930004851	sequence specific DNA binding site [nucleotide binding]; other site
374930004852	putative cAMP binding site [chemical binding]; other site
374930004853	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
374930004854	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
374930004855	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
374930004856	alphaNTD homodimer interface [polypeptide binding]; other site
374930004857	alphaNTD - beta interaction site [polypeptide binding]; other site
374930004858	alphaNTD - beta' interaction site [polypeptide binding]; other site
374930004859	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
374930004860	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
374930004861	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
374930004862	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
374930004863	RNA binding surface [nucleotide binding]; other site
374930004864	30S ribosomal protein S11; Validated; Region: PRK05309
374930004865	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
374930004866	30S ribosomal protein S13; Region: bact_S13; TIGR03631
374930004867	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
374930004868	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
374930004869	SecY translocase; Region: SecY; pfam00344
374930004870	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
374930004871	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
374930004872	23S rRNA binding site [nucleotide binding]; other site
374930004873	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
374930004874	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
374930004875	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
374930004876	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
374930004877	5S rRNA interface [nucleotide binding]; other site
374930004878	L27 interface [polypeptide binding]; other site
374930004879	23S rRNA interface [nucleotide binding]; other site
374930004880	L5 interface [polypeptide binding]; other site
374930004881	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
374930004882	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
374930004883	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
374930004884	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
374930004885	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
374930004886	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
374930004887	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
374930004888	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
374930004889	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
374930004890	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
374930004891	RNA binding site [nucleotide binding]; other site
374930004892	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
374930004893	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
374930004894	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
374930004895	23S rRNA interface [nucleotide binding]; other site
374930004896	putative translocon interaction site; other site
374930004897	signal recognition particle (SRP54) interaction site; other site
374930004898	L23 interface [polypeptide binding]; other site
374930004899	trigger factor interaction site; other site
374930004900	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
374930004901	23S rRNA interface [nucleotide binding]; other site
374930004902	5S rRNA interface [nucleotide binding]; other site
374930004903	putative antibiotic binding site [chemical binding]; other site
374930004904	L25 interface [polypeptide binding]; other site
374930004905	L27 interface [polypeptide binding]; other site
374930004906	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
374930004907	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
374930004908	G-X-X-G motif; other site
374930004909	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
374930004910	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
374930004911	protein-rRNA interface [nucleotide binding]; other site
374930004912	putative translocon binding site; other site
374930004913	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
374930004914	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
374930004915	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
374930004916	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
374930004917	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
374930004918	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
374930004919	potential frameshift: common BLAST hit: gi|68249373|ref|YP_248485.1| 50S ribosomal protein L3 [Haemophilus influenzae 86-028NP]
374930004920	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
374930004921	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
374930004922	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
374930004923	putative N- and C-terminal domain interface [polypeptide binding]; other site
374930004924	putative active site [active]
374930004925	putative MgATP binding site [chemical binding]; other site
374930004926	catalytic site [active]
374930004927	metal binding site [ion binding]; metal-binding site
374930004928	putative carbohydrate binding site [chemical binding]; other site
374930004929	transcriptional regulator LsrR; Provisional; Region: PRK15418
374930004930	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
374930004931	potential frameshift: common BLAST hit: gi|113460200|ref|YP_718257.1| ABC transporter, ATP-binding, sugar transport [Haemophilus somnus]
374930004932	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
374930004933	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930004934	TM-ABC transporter signature motif; other site
374930004935	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
374930004936	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
374930004937	TM-ABC transporter signature motif; other site
374930004938	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
374930004939	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
374930004940	ligand binding site [chemical binding]; other site
374930004941	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
374930004942	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
374930004943	putative active site; other site
374930004944	catalytic residue [active]
374930004945	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
374930004946	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
374930004947	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
374930004948	substrate binding site [chemical binding]; other site
374930004949	hexamer interface [polypeptide binding]; other site
374930004950	metal binding site [ion binding]; metal-binding site
374930004951	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
374930004952	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
374930004953	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
374930004954	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930004955	Walker A/P-loop; other site
374930004956	ATP binding site [chemical binding]; other site
374930004957	Q-loop/lid; other site
374930004958	ABC transporter signature motif; other site
374930004959	Walker B; other site
374930004960	D-loop; other site
374930004961	H-loop/switch region; other site
374930004962	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
374930004963	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
374930004964	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
374930004965	P loop; other site
374930004966	GTP binding site [chemical binding]; other site
374930004967	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
374930004968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930004969	S-adenosylmethionine binding site [chemical binding]; other site
374930004970	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
374930004971	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930004972	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
374930004973	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
374930004974	potential frameshift: common BLAST hit: gi|68249359|ref|YP_248471.1| nicotinamide-nucleotide adenylyltransferase [Haemophilus influenzae]
374930004975	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
374930004976	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
374930004977	active site
374930004978	metal binding site [ion binding]; metal-binding site
374930004979	Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639
374930004980	murein transglycosylase C; Provisional; Region: mltC; PRK11671
374930004981	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
374930004982	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
374930004983	N-acetyl-D-glucosamine binding site [chemical binding]; other site
374930004984	catalytic residue [active]
374930004985	oxidative damage protection protein; Provisional; Region: PRK05408
374930004986	adenine DNA glycosylase; Provisional; Region: PRK10880
374930004987	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
374930004988	minor groove reading motif; other site
374930004989	helix-hairpin-helix signature motif; other site
374930004990	substrate binding pocket [chemical binding]; other site
374930004991	active site
374930004992	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
374930004993	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
374930004994	DNA binding and oxoG recognition site [nucleotide binding]
374930004995	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
374930004996	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
374930004997	catalytic core [active]
374930004998	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
374930004999	potential frameshift: common BLAST hit: gi|68249352|ref|YP_248464.1| predicted membrane-bound metallopeptidase [Haemophilus influenzae]
374930005000	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
374930005001	NodB motif; other site
374930005002	putative active site [active]
374930005003	putative catalytic site [active]
374930005004	Zn binding site [ion binding]; other site
374930005005	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
374930005006	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
374930005007	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
374930005008	dimerization interface [polypeptide binding]; other site
374930005009	ATP binding site [chemical binding]; other site
374930005010	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
374930005011	dimerization interface [polypeptide binding]; other site
374930005012	ATP binding site [chemical binding]; other site
374930005013	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
374930005014	putative active site [active]
374930005015	catalytic triad [active]
374930005016	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
374930005017	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
374930005018	dimer interface [polypeptide binding]; other site
374930005019	catalytic triad [active]
374930005020	peroxidatic and resolving cysteines [active]
374930005021	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
374930005022	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
374930005023	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
374930005024	LexA repressor; Validated; Region: PRK00215
374930005025	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
374930005026	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
374930005027	Catalytic site [active]
374930005028	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
374930005029	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
374930005030	putative acyl-acceptor binding pocket; other site
374930005031	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
374930005032	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
374930005033	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
374930005034	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
374930005035	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
374930005036	active site
374930005037	homotetramer interface [polypeptide binding]; other site
374930005038	homodimer interface [polypeptide binding]; other site
374930005039	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
374930005040	active site residue [active]
374930005041	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
374930005042	SecA binding site; other site
374930005043	Preprotein binding site; other site
374930005044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
374930005045	similar to hypothetical protein; COG0702 Predicted nucleoside-diphosphate-sugar epimerases
374930005046	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
374930005047	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
374930005048	active site
374930005049	substrate binding site [chemical binding]; other site
374930005050	metal binding site [ion binding]; metal-binding site
374930005051	potential frameshift: common BLAST hit: gi|16272681|ref|NP_438899.1| DNA polymerase III subunit alpha [Haemophilus influenzae Rd KW20]
374930005052	threonine dehydratase; Reviewed; Region: PRK09224
374930005053	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
374930005054	tetramer interface [polypeptide binding]; other site
374930005055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
374930005056	catalytic residue [active]
374930005057	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
374930005058	putative Ile/Val binding site [chemical binding]; other site
374930005059	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
374930005060	putative Ile/Val binding site [chemical binding]; other site
374930005061	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
374930005062	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
374930005063	PYR/PP interface [polypeptide binding]; other site
374930005064	dimer interface [polypeptide binding]; other site
374930005065	TPP binding site [chemical binding]; other site
374930005066	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
374930005067	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
374930005068	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
374930005069	Na2 binding site [ion binding]; other site
374930005070	putative substrate binding site 1 [chemical binding]; other site
374930005071	Na binding site 1 [ion binding]; other site
374930005072	putative substrate binding site 2 [chemical binding]; other site
374930005073	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
374930005074	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
374930005075	putative active site [active]
374930005076	putative metal binding site [ion binding]; other site
374930005077	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
374930005078	putative acyl-acceptor binding pocket; other site
374930005079	FtsI repressor; Provisional; Region: PRK10883
374930005080	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
374930005081	potential frameshift: common BLAST hit: gi|68249331|ref|YP_248443.1| organic solvent tolerance protein precursor [Haemophilus influenzae]
374930005082	prolyl-tRNA synthetase; Provisional; Region: PRK09194
374930005083	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
374930005084	dimer interface [polypeptide binding]; other site
374930005085	motif 1; other site
374930005086	active site
374930005087	motif 2; other site
374930005088	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
374930005089	putative deacylase active site [active]
374930005090	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
374930005091	active site
374930005092	motif 3; other site
374930005093	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
374930005094	anticodon binding site; other site
374930005095	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
374930005096	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
374930005097	ATP binding site [chemical binding]; other site
374930005098	putative Mg++ binding site [ion binding]; other site
374930005099	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
374930005100	nucleotide binding region [chemical binding]; other site
374930005101	ATP-binding site [chemical binding]; other site
374930005102	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
374930005103	Helicase and RNase D C-terminal; Region: HRDC; smart00341
374930005104	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
374930005105	putative iron binding site [ion binding]; other site
374930005106	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
374930005107	diaminopimelate decarboxylase; Region: lysA; TIGR01048
374930005108	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
374930005109	active site
374930005110	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
374930005111	substrate binding site [chemical binding]; other site
374930005112	catalytic residues [active]
374930005113	dimer interface [polypeptide binding]; other site
374930005114	transcriptional regulator NarP; Provisional; Region: PRK10403
374930005115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
374930005116	active site
374930005117	phosphorylation site [posttranslational modification]
374930005118	intermolecular recognition site; other site
374930005119	dimerization interface [polypeptide binding]; other site
374930005120	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
374930005121	DNA binding residues [nucleotide binding]
374930005122	dimerization interface [polypeptide binding]; other site
374930005123	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
374930005124	Der GTPase activator (YihI); Region: YihI; cl01172
374930005125	Cation transport protein; Region: TrkH; cl17365
374930005126	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
374930005127	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
374930005128	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
374930005129	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
374930005130	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
374930005131	CPxP  motif; other site
374930005132	heat shock protein HtpX; Provisional; Region: PRK05457
374930005133	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
374930005134	homotrimer interaction site [polypeptide binding]; other site
374930005135	putative active site [active]
374930005136	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
374930005137	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
374930005138	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
374930005139	putative homodimer interface [polypeptide binding]; other site
374930005140	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
374930005141	heterodimer interface [polypeptide binding]; other site
374930005142	homodimer interface [polypeptide binding]; other site
374930005143	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
374930005144	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
374930005145	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
374930005146	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
374930005147	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
374930005148	Walker A motif; other site
374930005149	ATP binding site [chemical binding]; other site
374930005150	Walker B motif; other site
374930005151	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
374930005152	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
374930005153	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
374930005154	oligomer interface [polypeptide binding]; other site
374930005155	active site residues [active]
374930005156	trigger factor; Provisional; Region: tig; PRK01490
374930005157	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
374930005158	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
374930005159	potential frameshift: common BLAST hit: gi|30995391|ref|NP_438795.2| hemoglobin-binding protein [Haemophilus influenzae Rd KW20]
374930005160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
374930005161	RelB antitoxin; Region: RelB; pfam04221
374930005162	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
374930005163	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
374930005164	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
374930005165	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
374930005166	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
374930005167	G1 box; other site
374930005168	putative GEF interaction site [polypeptide binding]; other site
374930005169	GTP/Mg2+ binding site [chemical binding]; other site
374930005170	Switch I region; other site
374930005171	G2 box; other site
374930005172	G3 box; other site
374930005173	Switch II region; other site
374930005174	G4 box; other site
374930005175	G5 box; other site
374930005176	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
374930005177	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
374930005178	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
374930005179	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
374930005180	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
374930005181	selenocysteine synthase; Provisional; Region: PRK04311
374930005182	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
374930005183	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
374930005184	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
374930005185	catalytic residue [active]
374930005186	Archaeal ATPase; Region: Arch_ATPase; pfam01637
374930005187	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
374930005188	MutS domain I; Region: MutS_I; pfam01624
374930005189	MutS domain II; Region: MutS_II; pfam05188
374930005190	MutS domain III; Region: MutS_III; pfam05192
374930005191	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
374930005192	Walker A/P-loop; other site
374930005193	ATP binding site [chemical binding]; other site
374930005194	Q-loop/lid; other site
374930005195	ABC transporter signature motif; other site
374930005196	Walker B; other site
374930005197	D-loop; other site
374930005198	H-loop/switch region; other site
374930005199	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
374930005200	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
374930005201	Peptidase family M23; Region: Peptidase_M23; pfam01551
374930005202	Predicted membrane protein [Function unknown]; Region: COG1238
374930005203	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
374930005204	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
374930005205	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
374930005206	Permutation of conserved domain; other site
374930005207	active site
374930005208	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
374930005209	RNase E inhibitor protein; Provisional; Region: PRK11191
374930005210	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
374930005211	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
374930005212	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
374930005213	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
374930005214	Surface antigen; Region: Bac_surface_Ag; pfam01103
374930005215	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
374930005216	Family of unknown function (DUF490); Region: DUF490; pfam04357
374930005217	Family of unknown function (DUF490); Region: DUF490; pfam04357
374930005218	exopolyphosphatase; Region: exo_poly_only; TIGR03706
374930005219	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
374930005220	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
374930005221	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
374930005222	probable active site [active]
374930005223	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
374930005224	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
374930005225	ketol-acid reductoisomerase; Validated; Region: PRK05225
374930005226	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
374930005227	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
374930005228	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
374930005229	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
374930005230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
374930005231	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
374930005232	putative dimerization interface [polypeptide binding]; other site
374930005233	rarD protein; Region: rarD; TIGR00688
374930005234	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
374930005235	active site residue [active]
374930005236	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
374930005237	triosephosphate isomerase; Provisional; Region: PRK14567
374930005238	substrate binding site [chemical binding]; other site
374930005239	dimer interface [polypeptide binding]; other site
374930005240	catalytic triad [active]
374930005241	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
374930005242	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
374930005243	active site
374930005244	Int/Topo IB signature motif; other site
374930005245	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
374930005246	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
374930005247	metal binding site [ion binding]; metal-binding site
374930005248	dimer interface [polypeptide binding]; other site
374930005249	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930005250	active site
374930005251	glycerol kinase; Provisional; Region: glpK; PRK00047
374930005252	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
374930005253	N- and C-terminal domain interface [polypeptide binding]; other site
374930005254	active site
374930005255	MgATP binding site [chemical binding]; other site
374930005256	catalytic site [active]
374930005257	metal binding site [ion binding]; metal-binding site
374930005258	glycerol binding site [chemical binding]; other site
374930005259	homotetramer interface [polypeptide binding]; other site
374930005260	homodimer interface [polypeptide binding]; other site
374930005261	FBP binding site [chemical binding]; other site
374930005262	protein IIAGlc interface [polypeptide binding]; other site
374930005263	potential frameshift: common BLAST hit: gi|16272632|ref|NP_438850.1| glycerol uptake facilitator protein [Haemophilus influenzae Rd]
374930005264	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
374930005265	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
374930005266	active site
374930005267	catalytic site [active]
374930005268	metal binding site [ion binding]; metal-binding site
374930005269	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
374930005270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
374930005271	putative substrate translocation pore; other site
374930005272	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
374930005273	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
374930005274	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
374930005275	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
374930005276	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
374930005277	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
374930005278	Cysteine-rich domain; Region: CCG; pfam02754
374930005279	Cysteine-rich domain; Region: CCG; pfam02754
374930005280	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
374930005281	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
374930005282	Walker A/P-loop; other site
374930005283	ATP binding site [chemical binding]; other site
374930005284	Q-loop/lid; other site
374930005285	ABC transporter signature motif; other site
374930005286	Walker B; other site
374930005287	D-loop; other site
374930005288	H-loop/switch region; other site
374930005289	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
374930005290	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
374930005291	siderophore binding site; other site
374930005292	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
374930005293	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
374930005294	ABC-ATPase subunit  interface; other site
374930005295	dimer interface [polypeptide binding]; other site
374930005296	putative PBP binding regions; other site
374930005297	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
374930005298	ABC-ATPase subunit  interface; other site
374930005299	dimer interface [polypeptide binding]; other site
374930005300	putative PBP binding regions; other site
374930005301	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
374930005302	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
374930005303	N-terminal plug; other site
374930005304	ligand-binding site [chemical binding]; other site
374930005305	putative transposase OrfB; Reviewed; Region: PHA02517
374930005306	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
374930005307	active site
374930005308	similar to hypothetical protein; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins
374930005309	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
374930005310	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
374930005311	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
374930005312	substrate binding site; other site
374930005313	dimer interface; other site
374930005314	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
374930005315	homotrimer interaction site [polypeptide binding]; other site
374930005316	zinc binding site [ion binding]; other site
374930005317	CDP-binding sites; other site
374930005318	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
374930005319	putative active site [active]
374930005320	dimerization interface [polypeptide binding]; other site
374930005321	putative tRNAtyr binding site [nucleotide binding]; other site
374930005322	FMN-binding protein MioC; Provisional; Region: PRK09004
374930005323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074
374930005324	potential frameshift: common BLAST hit: gi|68249246|ref|YP_248358.1| fructose 1,6-bisphosphatase II [Haemophilus influenzae 86-028NP]
374930005325	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
374930005326	non-specific DNA binding site [nucleotide binding]; other site
374930005327	salt bridge; other site
374930005328	sequence-specific DNA binding site [nucleotide binding]; other site
374930005329	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
374930005330	HipA N-terminal domain; Region: Couple_hipA; pfam13657
374930005331	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
374930005332	HipA-like N-terminal domain; Region: HipA_N; pfam07805
374930005333	HipA-like C-terminal domain; Region: HipA_C; pfam07804
374930005334	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
374930005335	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
374930005336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930005337	Walker A/P-loop; other site
374930005338	ATP binding site [chemical binding]; other site
374930005339	Q-loop/lid; other site
374930005340	ABC transporter signature motif; other site
374930005341	Walker B; other site
374930005342	D-loop; other site
374930005343	H-loop/switch region; other site
374930005344	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
374930005345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
374930005346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
374930005347	Walker A/P-loop; other site
374930005348	ATP binding site [chemical binding]; other site
374930005349	Q-loop/lid; other site
374930005350	ABC transporter signature motif; other site
374930005351	Walker B; other site
374930005352	D-loop; other site
374930005353	H-loop/switch region; other site
374930005354	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
374930005355	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
374930005356	Phage-related protein [Function unknown]; Region: COG4679
374930005357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
374930005358	non-specific DNA binding site [nucleotide binding]; other site
374930005359	salt bridge; other site
374930005360	sequence-specific DNA binding site [nucleotide binding]; other site
374930005361	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
374930005362	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930005363	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930005364	ABC transporter; Region: ABC_tran_2; pfam12848
374930005365	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
374930005366	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
374930005367	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
374930005368	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
374930005369	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
374930005370	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
374930005371	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
374930005372	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
374930005373	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
374930005374	shikimate binding site; other site
374930005375	NAD(P) binding site [chemical binding]; other site
374930005376	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
374930005377	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
374930005378	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
374930005379	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
374930005380	putative metal binding site; other site
374930005381	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
374930005382	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
374930005383	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
374930005384	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
374930005385	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
374930005386	active site
374930005387	(T/H)XGH motif; other site
374930005388	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
374930005389	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
374930005390	Part of AAA domain; Region: AAA_19; pfam13245
374930005391	Family description; Region: UvrD_C_2; pfam13538
374930005392	Transcriptional regulator [Transcription]; Region: LysR; COG0583
374930005393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
374930005394	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
374930005395	dimerization interface [polypeptide binding]; other site
374930005396	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
374930005397	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
374930005398	MgtC family; Region: MgtC; pfam02308
374930005399	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
374930005400	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
374930005401	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
374930005402	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
374930005403	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
374930005404	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
374930005405	potential frameshift: common BLAST hit: gi|16272586|ref|NP_438803.1| biotin sulfoxide reductase [Haemophilus influenzae Rd KW20]
374930005406	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
374930005407	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
374930005408	Substrate binding site; other site
374930005409	Mg++ binding site; other site
374930005410	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
374930005411	active site
374930005412	substrate binding site [chemical binding]; other site
374930005413	CoA binding site [chemical binding]; other site
374930005414	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
374930005415	core dimer interface [polypeptide binding]; other site
374930005416	peripheral dimer interface [polypeptide binding]; other site
374930005417	L10 interface [polypeptide binding]; other site
374930005418	L11 interface [polypeptide binding]; other site
374930005419	putative EF-Tu interaction site [polypeptide binding]; other site
374930005420	putative EF-G interaction site [polypeptide binding]; other site
374930005421	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
374930005422	23S rRNA interface [nucleotide binding]; other site
374930005423	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
374930005424	adenylosuccinate lyase; Provisional; Region: PRK09285
374930005425	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
374930005426	tetramer interface [polypeptide binding]; other site
374930005427	active site
374930005428	Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915
374930005429	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
374930005430	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
374930005431	active site
374930005432	HIGH motif; other site
374930005433	dimer interface [polypeptide binding]; other site
374930005434	KMSKS motif; other site
374930005435	conserved hypothetical protein; Region: TIGR00743
374930005436	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
374930005437	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
374930005438	FMN binding site [chemical binding]; other site
374930005439	active site
374930005440	catalytic residues [active]
374930005441	substrate binding site [chemical binding]; other site
374930005442	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
374930005443	elongation factor Tu; Reviewed; Region: PRK00049
374930005444	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
374930005445	G1 box; other site
374930005446	GEF interaction site [polypeptide binding]; other site
374930005447	GTP/Mg2+ binding site [chemical binding]; other site
374930005448	Switch I region; other site
374930005449	G2 box; other site
374930005450	G3 box; other site
374930005451	Switch II region; other site
374930005452	G4 box; other site
374930005453	G5 box; other site
374930005454	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
374930005455	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
374930005456	Antibiotic Binding Site [chemical binding]; other site
374930005457	potential frameshift: common BLAST hit: gi|68249180|ref|YP_248292.1| pantothenate kinase [Haemophilus influenzae 86-028NP]
374930005458	anti-sigma E factor; Provisional; Region: rseB; PRK09455
374930005459	MucB/RseB family; Region: MucB_RseB; pfam03888
374930005460	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
374930005461	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
374930005462	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
374930005463	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
374930005464	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
374930005465	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
374930005466	DNA binding residues [nucleotide binding]
374930005467	Uncharacterized conserved protein [Function unknown]; Region: COG2938
374930005468	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
374930005469	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
374930005470	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
374930005471	TrkA-N domain; Region: TrkA_N; pfam02254
374930005472	TrkA-C domain; Region: TrkA_C; pfam02080
374930005473	TrkA-N domain; Region: TrkA_N; pfam02254
374930005474	TrkA-C domain; Region: TrkA_C; pfam02080
374930005475	16S rRNA methyltransferase B; Provisional; Region: PRK10901
374930005476	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
374930005477	putative RNA binding site [nucleotide binding]; other site
374930005478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
374930005479	S-adenosylmethionine binding site [chemical binding]; other site
374930005480	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
374930005481	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
374930005482	putative active site [active]
374930005483	substrate binding site [chemical binding]; other site
374930005484	putative cosubstrate binding site; other site
374930005485	catalytic site [active]
374930005486	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
374930005487	substrate binding site [chemical binding]; other site
374930005488	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
374930005489	active site
374930005490	catalytic residues [active]
374930005491	metal binding site [ion binding]; metal-binding site
374930005492	similar to hypothetical protein
374930005493	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
374930005494	TfoX C-terminal domain; Region: TfoX_C; pfam04994
374930005495	recombinase A; Provisional; Region: recA; PRK09354
374930005496	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
374930005497	hexamer interface [polypeptide binding]; other site
374930005498	Walker A motif; other site
374930005499	ATP binding site [chemical binding]; other site
374930005500	Walker B motif; other site
374930005501	recombination regulator RecX; Reviewed; Region: recX; PRK00117
374930005502	chromosome condensation membrane protein; Provisional; Region: PRK14196
374930005503	potential frameshift: common BLAST hit: gi|68249196|ref|YP_248308.1| predicted hydrolase of the HAD superfamily [Haemophilus influenzae]
374930005504	potential frameshift: common BLAST hit: gi|68249197|ref|YP_248309.1| ornithine carbamoyltransferase [Haemophilus influenzae 86-028NP]
374930005505	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
374930005506	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
374930005507	putative substrate binding site [chemical binding]; other site
374930005508	nucleotide binding site [chemical binding]; other site
374930005509	nucleotide binding site [chemical binding]; other site
374930005510	homodimer interface [polypeptide binding]; other site
374930005511	Predicted membrane protein [Function unknown]; Region: COG1288
374930005512	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606