-- dump date 20140619_104414 -- class Genbank::CDS -- table cds_note -- id note YP_001291510.1 COG3102 Uncharacterized protein conserved in bacteria YP_001291511.1 COG3102 Uncharacterized protein conserved in bacteria YP_001291512.1 COG3133 Outer membrane lipoprotein YP_001291515.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001291516.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001291517.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001291518.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001291520.1 COG0582 Integrase YP_001291522.1 COG0582 Integrase YP_001291524.1 COG4383 Mu-like prophage protein gp29 YP_001291525.1 COG5005 Mu-like prophage protein gpG YP_001291526.1 COG3475 LPS biosynthesis protein YP_001291527.1 COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes YP_001291528.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_001291530.1 COG4416 Mu-like prophage protein Com YP_001291531.1 COG3101 Uncharacterized protein conserved in bacteria YP_001291533.1 COG0790 FOG: TPR repeat, SEL1 subfamily YP_001291534.1 COG0790 FOG: TPR repeat, SEL1 subfamily YP_001291535.1 COG0790 FOG: TPR repeat, SEL1 subfamily YP_001291536.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001291537.1 COG1714 Predicted membrane protein/domain YP_001291538.1 COG2890 Methylase of polypeptide chain release factors YP_001291539.1 COG2912 Uncharacterized conserved protein YP_001291540.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001291541.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor YP_001291542.1 COG4591 ABC-type transport system, involved in lipoprotein release, permease component YP_001291543.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_001291544.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_001291545.1 COG2830 Uncharacterized protein conserved in bacteria YP_001291546.1 COG0500 SAM-dependent methyltransferases YP_001291547.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001291548.1 COG1136 ABC-type antimicrobial peptide transport system, ATPase component YP_001291549.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001291550.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001291552.1 involved in the import of serine and threonine coupled with the import of sodium YP_001291553.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) YP_001291554.1 COG3381 Uncharacterized component of anaerobic dehydrogenases YP_001291555.1 COG0778 Nitroreductase YP_001291556.1 COG3475 LPS biosynthesis protein YP_001291557.1 COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes YP_001291558.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_001291559.1 COG0510 Predicted choline kinase involved in LPS biosynthesis YP_001291560.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_001291561.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001291562.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_001291563.1 COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) YP_001291564.1 COG0786 Na+/glutamate symporter YP_001291565.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001291566.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001291567.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_001291569.1 COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase YP_001291570.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_001291571.1 COG0687 Spermidine/putrescine-binding periplasmic protein YP_001291572.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_001291573.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_001291574.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001291575.1 COG0783 DNA-binding ferritin-like protein (oxidative damage protectant) YP_001291576.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_001291577.1 COG0500 SAM-dependent methyltransferases YP_001291578.1 COG0591 Na+/proline symporter YP_001291579.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001291580.1 COG2983 Uncharacterized conserved protein YP_001291581.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001291582.1 COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases YP_001291583.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001291584.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001291585.1 COG0058 Glucan phosphorylase YP_001291586.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_001291587.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_001291588.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001291589.1 COG1182 Acyl carrier protein phosphodiesterase YP_001291590.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001291591.1 COG0612 Predicted Zn-dependent peptidases YP_001291593.1 COG3585 Molybdopterin-binding protein YP_001291594.1 COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit YP_001291595.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_001291597.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_001291598.1 COG3586 Uncharacterized conserved protein YP_001291599.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_001291600.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_001291602.1 COG2925 Exonuclease I YP_001291611.1 COG0181 Porphobilinogen deaminase YP_001291612.1 COG4128 Zonula occludens toxin YP_001291613.1 COG1450 Type II secretory pathway, component PulD YP_001291614.1 COG0642 Signal transduction histidine kinase YP_001291615.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001291616.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001291617.1 COG0581 ABC-type phosphate transport system, permease component YP_001291618.1 COG0573 ABC-type phosphate transport system, permease component YP_001291619.1 COG0226 ABC-type phosphate transport system, periplasmic component YP_001291620.1 COG1528 Ferritin-like protein YP_001291621.1 COG1528 Ferritin-like protein YP_001291622.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001291623.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_001291624.1 COG0512 Anthranilate/para-aminobenzoate synthases component II YP_001291625.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001291626.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_001291627.1 COG0298 Hydrogenase maturation factor YP_001291628.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001291631.1 COG0525 Valyl-tRNA synthetase YP_001291632.1 COG3097 Uncharacterized protein conserved in bacteria YP_001291633.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001291634.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001291635.1 COG0114 Fumarase YP_001291636.1 COG0613 Predicted metal-dependent phosphoesterases (PHP family) YP_001291637.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001291638.1 COG1855 ATPase (PilT family) YP_001291639.1 COG3566 Uncharacterized protein conserved in bacteria YP_001291640.1 COG2369 Uncharacterized protein, homolog of phage Mu protein gp30 YP_001291641.1 COG1783 Phage terminase large subunit YP_001291642.1 COG3728 Phage terminase, small subunit YP_001291645.1 COG1396 Predicted transcriptional regulators YP_001291647.1 COG3179 Predicted chitinase YP_001291648.1 COG3617 Prophage antirepressor YP_001291649.1 COG1196 Chromosome segregation ATPases YP_001291661.1 COG3646 Uncharacterized phage-encoded protein YP_001291662.1 COG4197 Uncharacterized protein conserved in bacteria, prophage-related YP_001291665.1 COG2932 Predicted transcriptional regulator YP_001291670.1 COG3422 Uncharacterized conserved protein YP_001291671.1 COG0419 ATPase involved in DNA repair YP_001291674.1 COG3561 Phage anti-repressor protein YP_001291675.1 COG0582 Integrase YP_001291677.1 COG0582 Integrase YP_001291678.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_001291679.1 with UspC and UspD is involved in resistance to UV irradiation YP_001291680.1 COG5266 ABC-type Co2+ transport system, periplasmic component YP_001291681.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001291682.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001291683.1 COG4221 Short-chain alcohol dehydrogenase of unknown specificity YP_001291684.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001291685.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001291686.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001291687.1 COG2606 Uncharacterized conserved protein YP_001291688.1 COG1278 Cold shock proteins YP_001291689.1 COG3140 Uncharacterized protein conserved in bacteria YP_001291690.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_001291691.1 COG3098 Uncharacterized protein conserved in bacteria YP_001291692.1 Required for the synthesis of the thiazole moiety YP_001291693.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001291694.1 COG0142 Geranylgeranyl pyrophosphate synthase YP_001291695.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001291696.1 COG2969 Stringent starvation protein B YP_001291697.1 COG0625 Glutathione S-transferase YP_001291698.1 forms a direct contact with the tRNA during translation YP_001291699.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001291700.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_001291701.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001291702.1 COG3100 Uncharacterized protein conserved in bacteria YP_001291703.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001291704.1 COG0303 Molybdopterin biosynthesis enzyme YP_001291705.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_001291706.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_001291707.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001291708.1 COG0785 Cytochrome c biogenesis protein YP_001291709.1 COG0225 Peptide methionine sulfoxide reductase YP_001291711.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_001291712.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001291715.1 COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog YP_001291716.1 COG1538 Outer membrane protein YP_001291717.1 COG2062 Phosphohistidine phosphatase SixA YP_001291718.1 COG0294 Dihydropteroate synthase and related enzymes YP_001291719.1 COG0465 ATP-dependent Zn proteases YP_001291720.1 COG0293 23S rRNA methylase YP_001291721.1 COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein YP_001291722.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001291723.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001291725.1 COG0184 Ribosomal protein S15P/S13E YP_001291726.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001291727.1 COG1067 Predicted ATP-dependent protease YP_001291728.1 COG3120 Uncharacterized protein conserved in bacteria YP_001291729.1 COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_001291730.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001291731.1 COG0291 Ribosomal protein L35 YP_001291732.1 COG0290 Translation initiation factor 3 (IF-3) YP_001291733.1 related to aldose 1-epimerase; COG0676 Uncharacterized enzymes related to aldose 1-epimerase YP_001291734.1 COG3119 Arylsulfatase A and related enzymes YP_001291735.1 COG0464 ATPases of the AAA+ class YP_001291736.1 COG1479 Uncharacterized conserved protein YP_001291737.1 COG0631 Serine/threonine protein phosphatase YP_001291738.1 COG0846 NAD-dependent protein deacetylases, SIR2 family YP_001291739.1 COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_001291740.1 COG0846 NAD-dependent protein deacetylases, SIR2 family YP_001291741.1 COG4502 Uncharacterized protein conserved in bacteria YP_001291743.1 COG2378 Predicted transcriptional regulator YP_001291744.1 COG0791 Cell wall-associated hydrolases (invasion-associated proteins) YP_001291745.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001291746.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001291747.1 COG0016 Phenylalanyl-tRNA synthetase alpha subunit YP_001291748.1 COG0633 Ferredoxin YP_001291749.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001291750.1 COG1280 Putative threonine efflux protein YP_001291751.1 COG1267 Phosphatidylglycerophosphatase A and related proteins YP_001291752.1 COG0611 Thiamine monophosphate kinase YP_001291753.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001291754.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001291755.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001291756.1 COG0288 Carbonic anhydrase YP_001291757.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_001291758.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_001291759.1 COG1346 Putative effector of murein hydrolase YP_001291760.1 COG1380 Putative effector of murein hydrolase LrgA YP_001291761.1 COG1525 Micrococcal nuclease (thermonuclease) homologs YP_001291762.1 COG0520 Selenocysteine lyase YP_001291763.1 COG2166 SufE protein probably involved in Fe-S center assembly YP_001291764.1 COG5595 Zn-ribbon-containing, possibly nucleic-acid-binding protein YP_001291765.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001291766.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_001291767.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001291770.1 COG0732 Restriction endonuclease S subunits YP_001291772.1 COG1338 Flagellar biosynthesis pathway, component FliP YP_001291773.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001291774.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001291775.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001291777.1 COG2801 Transposase and inactivated derivatives YP_001291778.1 COG1083 CMP-N-acetylneuraminic acid synthetase YP_001291779.1 COG0778 Nitroreductase YP_001291780.1 COG0489 ATPases involved in chromosome partitioning YP_001291781.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001291782.1 COG0491 Zn-dependent hydrolases, including glyoxylases YP_001291783.1 COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components YP_001291784.1 COG0609 ABC-type Fe3+-siderophore transport system, permease component YP_001291786.1 COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component YP_001291787.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_001291788.1 COG2949 Uncharacterized membrane protein YP_001291789.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001291791.1 COG1197 Transcription-repair coupling factor (superfamily II helicase) YP_001291792.1 COG1444 Predicted P-loop ATPase fused to an acetyltransferase YP_001291793.1 COG3094 Uncharacterized protein conserved in bacteria YP_001291794.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001291795.1 COG3093 Plasmid maintenance system antidote protein YP_001291796.1 COG3549 Plasmid maintenance system killer protein YP_001291797.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001291798.1 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_001291799.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001291800.1 COG3955 Exopolysaccharide biosynthesis protein YP_001291801.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_001291802.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_001291803.1 COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily YP_001291804.1 COG2860 Predicted membrane protein YP_001291805.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001291806.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001291807.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001291808.1 COG5339 Uncharacterized protein conserved in bacteria YP_001291809.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_001291810.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001291811.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_001291812.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001291813.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001291814.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001291815.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001291816.1 COG2233 Xanthine/uracil permeases YP_001291817.1 COG0593 ATPase involved in DNA replication initiation YP_001291818.1 involved in start site selection during the initiation of translation YP_001291819.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001291820.1 COG2956 Predicted N-acetylglucosaminyl transferase YP_001291821.1 COG3771 Predicted membrane protein YP_001291822.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001291823.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001291824.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001291825.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_001291826.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_001291827.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_001291828.1 COG0277 FAD/FMN-containing dehydrogenases YP_001291829.1 COG0312 Predicted Zn-dependent proteases and their inactivated homologs YP_001291830.1 COG0313 Predicted methyltransferases YP_001291831.1 COG3107 Putative lipoprotein YP_001291832.1 COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase YP_001291833.1 COG0279 Phosphoheptose isomerase YP_001291834.1 COG2823 Predicted periplasmic or secreted lipoprotein YP_001291835.1 COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_001291836.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001291837.1 COG0790 FOG: TPR repeat, SEL1 subfamily YP_001291843.1 COG0790 FOG: TPR repeat, SEL1 subfamily YP_001291845.1 COG3108 Uncharacterized protein conserved in bacteria YP_001291846.1 COG2989 Uncharacterized protein conserved in bacteria YP_001291847.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_001291848.1 affects solute and DNA transport through an unknown mechanism YP_001291849.1 COG3109 Activator of osmoprotectant transporter ProP YP_001291850.1 COG0314 Molybdopterin converting factor, large subunit YP_001291851.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001291852.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001291853.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001291854.1 Involved in anaerobic NO protection and iron metabolism YP_001291855.1 COG0794 Predicted sugar phosphate isomerase involved in capsule formation YP_001291856.1 COG1778 Low specificity phosphatase (HAD superfamily) YP_001291857.1 COG1289 Predicted membrane protein YP_001291858.1 COG3110 Uncharacterized protein conserved in bacteria YP_001291859.1 COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA YP_001291860.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001291861.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001291862.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_001291863.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_001291864.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001291865.1 COG0177 Predicted EndoIII-related endonuclease YP_001291866.1 COG0733 Na+-dependent transporters of the SNF family YP_001291867.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_001291868.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_001291869.1 COG0725 ABC-type molybdate transport system, periplasmic component YP_001291870.1 COG2005 N-terminal domain of molybdenum-binding protein YP_001291871.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001291872.1 COG3306 Glycosyltransferase involved in LPS biosynthesis YP_001291874.1 COG0438 Glycosyltransferase YP_001291875.1 COG1112 Superfamily I DNA and RNA helicases and helicase subunits YP_001291876.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid YP_001291877.1 COG1434 Uncharacterized conserved protein YP_001291878.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001291879.1 COG0795 Predicted permeases YP_001291880.1 COG0795 Predicted permeases YP_001291881.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001291882.1 COG1292 Choline-glycine betaine transporter YP_001291883.1 COG0642 Signal transduction histidine kinase YP_001291884.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001291886.1 COG3111 Uncharacterized conserved protein YP_001291887.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_001291888.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_001291889.1 COG1925 Phosphotransferase system, HPr-related proteins YP_001291890.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001291891.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001291892.1 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase YP_001291893.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001291894.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_001291895.1 COG3112 Uncharacterized protein conserved in bacteria YP_001291896.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001291897.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_001291898.1 COG1914 Mn2+ and Fe2+ transporters of the NRAMP family YP_001291899.1 COG1540 Uncharacterized proteins, homologs of lactam utilization protein B YP_001291900.1 COG2049 Allophanate hydrolase subunit 1 YP_001291901.1 COG5295 Autotransporter adhesin YP_001291902.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_001291903.1 COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH) YP_001291904.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001291905.1 COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance) YP_001291906.1 COG1296 Predicted branched-chain amino acid permease (azaleucine resistance) YP_001291907.1 COG0583 Transcriptional regulator YP_001291908.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_001291909.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001291910.1 catalyzes branch migration in Holliday junction intermediates YP_001291911.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001291912.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001291913.1 Essential for recycling GMP and indirectly, cGMP YP_001291914.1 COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_001291915.1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) YP_001291916.1 COG0561 Predicted hydrolases of the HAD superfamily YP_001291917.1 COG0319 Predicted metal-dependent hydrolase YP_001291918.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001291919.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing YP_001291920.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing YP_001291921.1 COG0437 Fe-S-cluster-containing hydrogenase components 1 YP_001291922.1 required for the formation of active formate dehydrogenase YP_001291923.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_001291924.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001291925.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_001291926.1 COG1159 GTPase YP_001291927.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001291928.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001291929.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_001291930.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001291931.1 COG0471 Di- and tricarboxylate transporters YP_001291932.1 COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) YP_001291933.1 COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) YP_001291934.1 COG2301 Citrate lyase beta subunit YP_001291935.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_001291936.1 COG3053 Citrate lyase synthetase YP_001291937.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001291938.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001291939.1 COG2921 Uncharacterized conserved protein YP_001291940.1 COG0772 Bacterial cell division membrane protein YP_001291941.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_001291942.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001291943.1 COG0799 Uncharacterized homolog of plant Iojap protein YP_001291944.1 COG2985 Predicted permease YP_001291945.1 COG4178 ABC-type uncharacterized transport system, permease and ATPase components YP_001291946.1 functions in MreBCD complex in some organisms YP_001291947.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001291948.1 COG2891 Cell shape-determining protein YP_001291949.1 COG3076 Uncharacterized protein conserved in bacteria YP_001291950.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_001291951.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_001291952.1 COG3768 Predicted membrane protein YP_001291953.1 COG0670 Integral membrane protein, interacts with FtsH YP_001291954.1 COG3054 Predicted transcriptional regulator YP_001291955.1 COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism YP_001291956.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001291957.1 COG2211 Na+/melibiose symporter and related transporters YP_001291958.1 COG1472 Beta-glucosidase-related glycosidases YP_001291959.1 COG0546 Predicted phosphatases YP_001291960.1 Converts D-mannonate to D-mannuronate YP_001291961.1 COG3676 Transposase and inactivated derivatives YP_001291962.1 COG2186 Transcriptional regulators YP_001291963.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001291964.1 COG0861 Membrane protein TerC, possibly involved in tellurium resistance YP_001291965.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001291966.1 COG1663 Tetraacyldisaccharide-1-P 4'-kinase YP_001291967.1 involved in the transport of lipid A across the inner membrane YP_001291968.1 COG1734 DnaK suppressor protein YP_001291969.1 COG0617 tRNA nucleotidyltransferase/poly(A) polymerase YP_001291970.1 COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase YP_001291971.1 COG0802 Predicted ATPase or kinase YP_001291972.1 COG0860 N-acetylmuramoyl-L-alanine amidase YP_001291973.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001291974.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001291975.1 catalyzes the phosphorylation of NAD to NADP YP_001291976.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001291978.1 COG1708 Predicted nucleotidyltransferases YP_001291979.1 COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase YP_001291981.1 COG1946 Acyl-CoA thioesterase YP_001291982.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001291983.1 COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_001291984.1 COG0084 Mg-dependent DNase YP_001291986.1 COG1960 Acyl-CoA dehydrogenases YP_001291987.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001291988.1 COG1052 Lactate dehydrogenase and related dehydrogenases YP_001291989.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001291990.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001291991.1 COG0527 Aspartokinases YP_001291992.1 COG0325 Predicted enzyme with a TIM-barrel fold YP_001291994.1 COG1840 ABC-type Fe3+ transport system, periplasmic component YP_001291995.1 COG1876 D-alanyl-D-alanine carboxypeptidase YP_001291996.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001291997.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family YP_001291998.1 molecular chaperone YP_001291999.1 COG0286 Type I restriction-modification system methyltransferase subunit YP_001292000.1 COG0732 Restriction endonuclease S subunits YP_001292001.1 COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases YP_001292002.1 COG0541 Signal recognition particle GTPase YP_001292004.1 COG4536 Putative Mg2+ and Co2+ transporter CorB YP_001292005.1 COG2966 Uncharacterized conserved protein YP_001292007.1 COG3610 Uncharacterized conserved protein YP_001292008.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001292009.1 COG0625 Glutathione S-transferase YP_001292010.1 COG2963 Transposase and inactivated derivatives YP_001292011.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001292012.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001292013.1 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 YP_001292014.1 involved in transport of zinc(II) with ZnuA and C YP_001292015.1 COG5413 Uncharacterized integral membrane protein YP_001292017.1 COG0773 UDP-N-acetylmuramate-alanine ligase YP_001292018.1 catalyzes the formation of L-homocysteine from cystathionine YP_001292019.1 COG0450 Peroxiredoxin YP_001292022.1 COG0221 Inorganic pyrophosphatase YP_001292023.1 COG2252 Permeases YP_001292024.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import YP_001292025.1 COG1178 ABC-type Fe3+ transport system, permease component YP_001292026.1 COG1840 ABC-type Fe3+ transport system, periplasmic component YP_001292027.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_001292028.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001292029.1 COG2814 Arabinose efflux permease YP_001292030.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001292031.1 3'-5' exonuclease of DNA polymerase III YP_001292032.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001292033.1 COG3203 Outer membrane protein (porin) YP_001292034.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_001292035.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase YP_001292036.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_001292037.1 COG1737 Transcriptional regulators YP_001292038.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_001292039.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001292040.1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component YP_001292041.1 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component YP_001292042.1 COG3055 Uncharacterized protein conserved in bacteria YP_001292043.1 COG2020 Putative protein-S-isoprenylcysteine methyltransferase YP_001292044.1 COG0330 Membrane protease subunits, stomatin/prohibitin homologs YP_001292046.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_001292047.1 carries the fatty acid chain in fatty acid biosynthesis YP_001292048.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001292049.1 COG0331 (acyl-carrier-protein) S-malonyltransferase YP_001292050.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001292051.1 COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III YP_001292052.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001292053.1 COG1399 Predicted metal-binding, possibly nucleic acid-binding protein YP_001292054.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001292055.1 COG3056 Uncharacterized lipoprotein YP_001292056.1 COG0271 Stress-induced morphogen (activity unknown) YP_001292057.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001292058.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001292059.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001292060.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_001292061.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_001292062.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001292063.1 COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis YP_001292064.1 COG2991 Uncharacterized protein conserved in bacteria YP_001292065.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001292066.1 COG1496 Uncharacterized conserved protein YP_001292067.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_001292068.1 COG4105 DNA uptake lipoprotein YP_001292069.1 COG0525 Valyl-tRNA synthetase YP_001292070.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_001292071.1 COG1882 Pyruvate-formate lyase YP_001292072.1 COG1882 Pyruvate-formate lyase YP_001292073.1 COG2116 Formate/nitrite family of transporters YP_001292074.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_001292075.1 COG1115 Na+/alanine symporter YP_001292076.1 COG0627 Predicted esterase YP_001292077.1 COG1062 Zn-dependent alcohol dehydrogenases, class III YP_001292078.1 COG0789 Predicted transcriptional regulators YP_001292079.1 COG1826 Sec-independent protein secretion pathway components YP_001292080.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_001292081.1 COG0805 Sec-independent protein secretion pathway component TatC YP_001292082.1 COG0735 Fe2+/Zn2+ uptake regulation proteins YP_001292083.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001292084.1 COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_001292085.1 negative modulator of the initiation of chromosome replication YP_001292086.1 COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_001292087.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_001292088.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001292089.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001292090.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_001292091.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001292092.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001292093.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001292094.1 Essential for efficient processing of 16S rRNA YP_001292095.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001292096.1 COG0228 Ribosomal protein S16 YP_001292097.1 COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases YP_001292098.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001292099.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001292101.1 COG0338 Site-specific DNA methylase YP_001292102.1 COG0671 Membrane-associated phospholipid phosphatase YP_001292103.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_001292104.1 COG4166 ABC-type oligopeptide transport system, periplasmic component YP_001292105.1 COG2832 Uncharacterized protein conserved in bacteria YP_001292106.1 COG0339 Zn-dependent oligopeptidases YP_001292107.1 COG0286 Type I restriction-modification system methyltransferase subunit YP_001292108.1 COG0732 Restriction endonuclease S subunits YP_001292109.1 COG1943 Transposase and inactivated derivatives YP_001292110.1 COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases YP_001292111.1 COG3059 Predicted membrane protein YP_001292112.1 COG0642 Signal transduction histidine kinase YP_001292113.1 COG1573 Uracil-DNA glycosylase YP_001292114.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_001292115.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001292116.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001292117.1 COG2962 Predicted permeases YP_001292118.1 COG1522 Transcriptional regulators YP_001292119.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001292120.1 COG1114 Branched-chain amino acid permeases YP_001292122.1 COG2731 Beta-galactosidase, beta subunit YP_001292124.1 COG0513 Superfamily II DNA and RNA helicases YP_001292125.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_001292127.1 COG4623 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein YP_001292128.1 COG3036 Uncharacterized protein conserved in bacteria YP_001292129.1 COG1393 Arsenate reductase and related proteins, glutaredoxin family YP_001292130.1 COG0628 Predicted permease YP_001292131.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001292132.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001292133.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001292134.1 COG0425 Predicted redox protein, regulator of disulfide bond formation YP_001292135.1 COG0457 FOG: TPR repeat YP_001292136.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001292137.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001292138.1 COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) YP_001292139.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001292140.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_001292141.1 COG0582 Integrase YP_001292142.1 COG4688 Uncharacterized protein conserved in bacteria YP_001292143.1 COG3621 Patatin YP_001292144.1 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 YP_001292147.1 COG0810 Periplasmic protein TonB, links inner and outer membranes YP_001292148.1 COG0848 Biopolymer transport protein YP_001292149.1 COG0811 Biopolymer transport proteins YP_001292150.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_001292151.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001292152.1 COG3317 Uncharacterized lipoprotein YP_001292153.1 COG1544 Ribosome-associated protein Y (PSrp-1) YP_001292154.1 COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system YP_001292155.1 COG2161 Antitoxin of toxin-antitoxin stability system YP_001292160.1 COG5519 Superfamily II helicase and inactivated derivatives YP_001292163.1 COG0553 Superfamily II DNA/RNA helicases, SNF2 family YP_001292164.1 COG1196 Chromosome segregation ATPases YP_001292165.1 COG1196 Chromosome segregation ATPases YP_001292167.1 COG3311 Predicted transcriptional regulator YP_001292168.1 COG0582 Integrase YP_001292169.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001292170.1 catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position YP_001292171.1 COG0859 ADP-heptose:LPS heptosyltransferase YP_001292172.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_001292173.1 COG2831 Hemolysin activation/secretion protein YP_001292174.1 COG1539 Dihydroneopterin aldolase YP_001292175.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001292176.1 COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific YP_001292177.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001292178.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_001292179.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001292180.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001292181.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001292182.1 COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_001292183.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_001292184.1 COG3012 Uncharacterized protein conserved in bacteria YP_001292185.1 COG2258 Uncharacterized protein conserved in bacteria YP_001292186.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_001292187.1 COG0477 Permeases of the major facilitator superfamily YP_001292188.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_001292189.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001292191.1 COG1169 Isochorismate synthase YP_001292192.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001292193.1 COG0814 Amino acid permeases YP_001292194.1 COG0814 Amino acid permeases YP_001292195.1 COG2217 Cation transport ATPase YP_001292196.1 COG2608 Copper chaperone YP_001292197.1 COG2608 Copper chaperone YP_001292198.1 COG2608 Copper chaperone YP_001292199.1 COG2608 Copper chaperone YP_001292200.1 COG0789 Predicted transcriptional regulators YP_001292201.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_001292202.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001292203.1 COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases YP_001292204.1 COG1459 Type II secretory pathway, component PulF YP_001292205.1 COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB YP_001292206.1 COG4969 Tfp pilus assembly protein, major pilin PilA YP_001292207.1 COG3023 Negative regulator of beta-lactamase expression YP_001292208.1 COG4535 Putative Mg2+ and Co2+ transporter CorC YP_001292209.1 Transfers the fatty acyl group on membrane lipoproteins YP_001292210.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001292211.1 COG1678 Putative transcriptional regulator YP_001292212.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001292213.1 Required for efficient pilin antigenic variation YP_001292214.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001292215.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_001292216.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001292217.1 COG1196 Chromosome segregation ATPases YP_001292218.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001292219.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001292220.1 COG0217 Uncharacterized conserved protein YP_001292221.1 converts dATP to dAMP and pyrophosphate YP_001292222.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001292223.1 COG1755 Uncharacterized protein conserved in bacteria YP_001292224.1 COG0500 SAM-dependent methyltransferases YP_001292225.1 COG0346 Lactoylglutathione lyase and related lyases YP_001292226.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001292227.1 COG2056 Predicted permease YP_001292228.1 COG3923 Primosomal replication protein N'' YP_001292229.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001292231.1 COG3061 Cell envelope opacity-associated protein A YP_001292232.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001292233.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001292234.1 COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001292235.1 COG0818 Diacylglycerol kinase YP_001292236.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001292237.1 COG0347 Nitrogen regulatory protein PII YP_001292238.1 COG0628 Predicted permease YP_001292239.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001292240.1 COG3171 Uncharacterized protein conserved in bacteria YP_001292241.1 COG1145 Ferredoxin YP_001292242.1 COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase YP_001292243.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_001292244.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_001292247.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001292260.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001292261.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001292265.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001292267.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001292270.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001292327.1 Required for efficient pilin antigenic variation YP_001292340.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001292341.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_001292342.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001292346.1 COG0349 Ribonuclease D YP_001292347.1 COG1835 Predicted acyltransferases YP_001292348.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001292349.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001292350.1 COG2914 Uncharacterized protein conserved in bacteria YP_001292351.1 COG2850 Uncharacterized conserved protein YP_001292352.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001292353.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_001292354.1 COG1409 Predicted phosphohydrolases YP_001292355.1 COG3691 Uncharacterized protein conserved in bacteria YP_001292356.1 COG2067 Long-chain fatty acid transport protein YP_001292357.1 COG0350 Methylated DNA-protein cysteine methyltransferase YP_001292358.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_001292359.1 COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_001292360.1 COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase YP_001292361.1 COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components YP_001292362.1 COG1121 ABC-type Mn/Zn transport systems, ATPase component YP_001292363.1 COG3283 Transcriptional regulator of aromatic amino acids metabolism YP_001292364.1 Stimulates the elongation of poly(A) tails YP_001292365.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_001292367.1 COG1530 Ribonucleases G and E YP_001292368.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001292369.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_001292370.1 COG0477 Permeases of the major facilitator superfamily YP_001292371.1 COG4453 Uncharacterized protein conserved in bacteria YP_001292372.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_001292373.1 COG5295 Autotransporter adhesin YP_001292374.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_001292375.1 COG4123 Predicted O-methyltransferase YP_001292376.1 COG0566 rRNA methylases YP_001292377.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_001292378.1 Multifunctional regulator of fatty acid metabolism YP_001292379.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_001292380.1 COG0776 Bacterial nucleoid DNA-binding protein YP_001292381.1 COG3068 Uncharacterized protein conserved in bacteria YP_001292382.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_001292383.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_001292384.1 COG1040 Predicted amidophosphoribosyltransferases YP_001292389.1 COG4796 Type II secretory pathway, component HofQ YP_001292390.1 COG5009 Membrane carboxypeptidase/penicillin-binding protein YP_001292391.1 COG0718 Uncharacterized protein conserved in bacteria YP_001292392.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001292393.1 decatenates replicating daughter chromosomes YP_001292394.1 COG1314 Preprotein translocase subunit SecG YP_001292395.1 COG3925 N-terminal domain of the phosphotransferase system fructose-specific component IIB YP_001292396.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_001292397.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_001292398.1 COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain YP_001292400.1 COG3309 Uncharacterized virulence-associated protein D YP_001292401.1 COG1253 Hemolysins and related proteins containing CBS domains YP_001292402.1 COG0084 Mg-dependent DNase YP_001292403.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001292404.1 COG0470 ATPase involved in DNA replication YP_001292405.1 COG3468 Type V secretory pathway, adhesin AidA YP_001292406.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001292407.1 COG1559 Predicted periplasmic solute-binding protein YP_001292408.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_001292409.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_001292410.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001292411.1 COG2990 Uncharacterized protein conserved in bacteria YP_001292412.1 COG0466 ATP-dependent Lon protease, bacterial type YP_001292413.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001292414.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001292415.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001292416.1 COG0354 Predicted aminomethyltransferase related to GcvT YP_001292418.1 COG1561 Uncharacterized stress-induced protein YP_001292419.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001292420.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001292421.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001292422.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_001292423.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001292424.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001292425.1 COG0140 Phosphoribosyl-ATP pyrophosphohydrolase YP_001292426.1 COG0814 Amino acid permeases YP_001292427.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001292428.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001292429.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001292430.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001292431.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001292432.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001292433.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001292434.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001292435.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_001292436.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001292437.1 COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division YP_001292438.1 COG0637 Predicted phosphatase/phosphohexomutase YP_001292439.1 COG1238 Predicted membrane protein YP_001292440.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001292441.1 COG2963 Transposase and inactivated derivatives YP_001292442.1 COG2801 Transposase and inactivated derivatives YP_001292443.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_001292444.1 heat shock protein involved in degradation of misfolded proteins YP_001292445.1 COG0687 Spermidine/putrescine-binding periplasmic protein YP_001292446.1 COG1322 Uncharacterized protein conserved in bacteria YP_001292447.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001292448.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_001292449.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_001292450.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_001292451.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_001292452.1 COG1609 Transcriptional regulators YP_001292453.1 COG2862 Predicted membrane protein YP_001292454.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001292455.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001292456.1 COG1720 Uncharacterized conserved protein YP_001292457.1 COG1275 Tellurite resistance protein and related permeases YP_001292458.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001292459.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001292460.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001292461.1 binds directly to 23S ribosomal RNA YP_001292462.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001292463.1 COG1972 Nucleoside permease YP_001292464.1 COG1180 Pyruvate-formate lyase-activating enzyme YP_001292465.1 COG1882 Pyruvate-formate lyase YP_001292466.1 COG2364 Predicted membrane protein YP_001292467.1 COG0859 ADP-heptose:LPS heptosyltransferase YP_001292468.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001292469.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001292470.1 COG3719 Ribonuclease I YP_001292471.1 COG1145 Ferredoxin YP_001292472.1 COG0814 Amino acid permeases YP_001292473.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001292474.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001292475.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001292476.1 synthesizes RNA primers at the replication forks YP_001292478.1 COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) YP_001292479.1 catalyzes the formation of fumarate from aspartate YP_001292480.1 COG0829 Urease accessory protein UreH YP_001292481.1 COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase YP_001292482.1 COG0830 Urease accessory protein UreF YP_001292483.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_001292484.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_001292485.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_001292486.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001292487.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001292488.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001292489.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001292490.1 COG2965 Primosomal replication protein N YP_001292491.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001292492.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001292494.1 COG3306 Glycosyltransferase involved in LPS biosynthesis YP_001292495.1 COG0438 Glycosyltransferase YP_001292496.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001292497.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001292498.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases YP_001292499.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001292500.1 COG1943 Transposase and inactivated derivatives YP_001292501.1 COG3759 Predicted membrane protein YP_001292502.1 COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase YP_001292503.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001292505.1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase YP_001292506.1 COG1297 Predicted membrane protein YP_001292507.1 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_001292508.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_001292509.1 catalyzes the formation of asparagine from aspartate and ammonia YP_001292510.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001292511.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001292512.1 negatively supercoils closed circular double-stranded DNA YP_001292513.1 COG2183 Transcriptional accessory protein YP_001292514.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001292515.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_001292516.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_001292517.1 COG0678 Peroxiredoxin YP_001292518.1 COG2900 Uncharacterized protein conserved in bacteria YP_001292519.1 COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 YP_001292520.1 COG2964 Uncharacterized protein conserved in bacteria YP_001292521.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001292522.1 COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur YP_001292523.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001292524.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_001292525.1 COG3073 Negative regulator of sigma E activity YP_001292526.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001292527.1 COG2938 Uncharacterized conserved protein YP_001292528.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001292529.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001292530.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001292531.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001292538.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001292539.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001292540.1 COG0239 Integral membrane protein possibly involved in chromosome condensation YP_001292541.1 COG0561 Predicted hydrolases of the HAD superfamily YP_001292542.1 COG0078 Ornithine carbamoyltransferase YP_001292543.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001292544.1 COG1288 Predicted membrane protein YP_001292545.1 COG1522 Transcriptional regulators YP_001292546.1 COG1522 Transcriptional regulators YP_001292548.1 COG0078 Ornithine carbamoyltransferase YP_001292549.1 COG1982 Arginine/lysine/ornithine decarboxylases YP_001292550.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_001292551.1 COG3086 Positive regulator of sigma E activity YP_001292552.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001292553.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_001292554.1 COG3069 C4-dicarboxylate transporter YP_001292555.1 COG0789 Predicted transcriptional regulators YP_001292556.1 COG1230 Co/Zn/Cd efflux system component YP_001292557.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001292558.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001292559.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001292560.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001292561.1 COG0038 Chloride channel protein EriC YP_001292562.1 COG0038 Chloride channel protein EriC YP_001292563.1 COG0042 tRNA-dihydrouridine synthase YP_001292565.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_001292566.1 COG3691 Uncharacterized protein conserved in bacteria YP_001292567.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001292568.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_001292569.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001292570.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001292571.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001292572.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001292573.1 COG0805 Sec-independent protein secretion pathway component TatC YP_001292574.1 COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit YP_001292575.1 COG2267 Lysophospholipase YP_001292576.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001292577.1 COG1285 Uncharacterized membrane protein YP_001292578.1 COG0621 2-methylthioadenine synthetase YP_001292579.1 COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) YP_001292581.1 COG0210 Superfamily I DNA and RNA helicases YP_001292582.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001292583.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001292584.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001292586.1 COG2818 3-methyladenine DNA glycosylase YP_001292587.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001292588.1 COG0009 Putative translation factor (SUA5) YP_001292589.1 COG0551 Zn-finger domain associated with topoisomerase type I YP_001292590.1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains YP_001292591.1 COG1396 Predicted transcriptional regulators YP_001292592.1 COG4679 Phage-related protein YP_001292593.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_001292594.1 COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components YP_001292595.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001292596.1 COG3074 Uncharacterized protein conserved in bacteria YP_001292597.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001292598.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001292599.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001292600.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001292601.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_001292603.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001292604.1 COG2195 Di- and tripeptidases YP_001292605.1 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases YP_001292606.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001292607.1 COG0607 Rhodanese-related sulfurtransferase YP_001292608.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_001292609.1 COG0583 Transcriptional regulator YP_001292610.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001292611.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_001292612.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_001292613.1 COG2271 Sugar phosphate permease YP_001292614.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_001292615.1 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_001292616.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001292617.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001292618.1 COG0584 Glycerophosphoryl diester phosphodiesterase YP_001292619.1 COG2503 Predicted secreted acid phosphatase YP_001292620.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_001292621.1 COG0248 Exopolyphosphatase YP_001292622.1 COG2911 Uncharacterized protein conserved in bacteria YP_001292623.1 COG0729 Outer membrane protein YP_001292624.1 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 YP_001292625.1 COG3076 Uncharacterized protein conserved in bacteria YP_001292626.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001292627.1 COG1238 Predicted membrane protein YP_001292628.1 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases YP_001292630.1 COG0814 Amino acid permeases YP_001292631.1 COG3276 Selenocysteine-specific translation elongation factor YP_001292632.1 COG0642 Signal transduction histidine kinase YP_001292633.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_001292634.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001292635.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001292636.1 binds and unfolds substrates as part of the ClpXP protease YP_001292637.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001292638.1 Modulates Rho-dependent transcription termination YP_001292639.1 COG2853 Surface lipoprotein YP_001292640.1 COG0251 Putative translation initiation inhibitor, yjgF family YP_001292641.1 putative metalloprotease YP_001292642.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_001292643.1 COG1739 Uncharacterized conserved protein YP_001292644.1 COG0168 Trk-type K+ transport systems, membrane components YP_001292646.1 COG3223 Predicted membrane protein YP_001292647.1 COG3071 Uncharacterized enzyme of heme biosynthesis YP_001292648.1 COG2959 Uncharacterized enzyme of heme biosynthesis YP_001292649.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_001292650.1 catalyzes the O-acetylation of serine YP_001292651.1 catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001292652.1 COG0471 Di- and tricarboxylate transporters YP_001292653.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001292654.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_001292655.1 COG4154 Fucose dissimilation pathway protein FucU YP_001292656.1 COG2407 L-fucose isomerase and related proteins YP_001292657.1 COG1349 Transcriptional regulators of sugar metabolism YP_001292658.1 COG0564 Pseudouridylate synthases, 23S RNA-specific YP_001292659.1 COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_001292660.1 COG1349 Transcriptional regulators of sugar metabolism YP_001292661.1 COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen YP_001292662.1 COG2011 ABC-type metal ion transport system, permease component YP_001292663.1 part of the metNIQ transport system for methionine YP_001292664.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_001292666.1 COG3078 Uncharacterized protein conserved in bacteria YP_001292667.1 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_001292669.1 COG0019 Diaminopimelate decarboxylase YP_001292670.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001292671.1 COG0514 Superfamily II DNA helicase YP_001292672.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001292673.1 COG2132 Putative multicopper oxidases YP_001292674.1 COG2132 Putative multicopper oxidases YP_001292675.1 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_001292676.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001292677.1 COG2908 Uncharacterized protein conserved in bacteria YP_001292678.1 COG0733 Na+-dependent transporters of the SNF family YP_001292680.1 COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] YP_001292681.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001292683.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001292686.1 COG0702 Predicted nucleoside-diphosphate-sugar epimerases YP_001292687.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001292688.1 COG0607 Rhodanese-related sulfurtransferase YP_001292689.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_001292690.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001292691.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001292692.1 Represses a number of genes involved in the response to DNA damage YP_001292693.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001292694.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001292695.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001292696.1 COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain YP_001292697.1 COG3306 Glycosyltransferase involved in LPS biosynthesis YP_001292698.1 COG2861 Uncharacterized protein conserved in bacteria YP_001292699.1 COG4942 Membrane-bound metallopeptidase YP_001292700.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001292701.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001292702.1 COG1194 A/G-specific DNA glycosylase YP_001292703.1 COG2924 Fe-S cluster protector protein YP_001292704.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001292705.1 COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases YP_001292706.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_001292707.1 DHBP synthase; functions during riboflavin biosynthesis YP_001292708.1 COG3306 Glycosyltransferase involved in LPS biosynthesis YP_001292709.1 COG0219 Predicted rRNA methylase (SpoU class) YP_001292710.1 COG0742 N6-adenine-specific methylase YP_001292711.1 COG0552 Signal recognition particle GTPase YP_001292712.1 COG2884 Predicted ATPase involved in cell division YP_001292713.1 putative ABC transporter, membrane protein YP_001292714.1 COG0183 Acetyl-CoA acetyltransferase YP_001292715.1 COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit YP_001292716.1 COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit YP_001292717.1 COG0583 Transcriptional regulator YP_001292718.1 COG0051 Ribosomal protein S10 YP_001292719.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001292720.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001292721.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001292722.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001292723.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001292724.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001292725.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001292726.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001292727.1 one of the stabilizing components for the large ribosomal subunit YP_001292728.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001292729.1 COG0186 Ribosomal protein S17 YP_001292730.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001292731.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001292732.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001292733.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001292734.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001292735.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001292736.1 binds 5S rRNA along with protein L5 and L25 YP_001292737.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001292738.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001292739.1 late assembly protein YP_001292740.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001292741.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001292742.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001292743.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001292744.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001292745.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001292746.1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_001292747.1 COG0730 Predicted permeases YP_001292748.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001292749.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001292750.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001292751.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001292752.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001292753.1 COG1210 UDP-glucose pyrophosphorylase YP_001292754.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001292755.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001292756.1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins YP_001292757.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_001292758.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_001292759.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001292760.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_001292761.1 COG1609 Transcriptional regulators YP_001292762.1 COG1879 ABC-type sugar transport system, periplasmic component YP_001292763.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_001292764.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_001292765.1 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid YP_001292766.1 Involved in cell division; probably involved in intracellular septation YP_001292767.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001292768.1 COG1196 Chromosome segregation ATPases YP_001292769.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_001292770.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_001292771.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_001292772.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001292773.1 COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit YP_001292774.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001292775.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001292776.1 COG2913 Small protein A (tmRNA-binding) YP_001292777.1 COG3081 Nucleoid-associated protein YP_001292778.1 COG3082 Uncharacterized protein conserved in bacteria YP_001292779.1 COG3083 Predicted hydrolase of alkaline phosphatase superfamily YP_001292780.1 COG0402 Cytosine deaminase and related metal-dependent hydrolases YP_001292781.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001292782.1 COG3084 Uncharacterized protein conserved in bacteria YP_001292783.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001292784.1 COG3085 Uncharacterized protein conserved in bacteria YP_001292785.1 COG0500 SAM-dependent methyltransferases YP_001292788.1 COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein YP_001292789.1 COG0477 Permeases of the major facilitator superfamily YP_001292790.1 COG0748 Putative heme iron utilization protein YP_001292791.1 COG3681 Uncharacterized conserved protein YP_001292792.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001292793.1 COG3027 Uncharacterized protein conserved in bacteria YP_001292794.1 COG0212 5-formyltetrahydrofolate cyclo-ligase YP_001292795.1 COG0542 ATPases with chaperone activity, ATP-binding subunit YP_001292796.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_001292797.1 COG0557 Exoribonuclease R YP_001292798.1 COG1738 Uncharacterized conserved protein YP_001292799.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001292801.1 COG1217 Predicted membrane GTPase involved in stress response YP_001292802.1 COG0174 Glutamine synthetase YP_001292803.1 COG3765 Chain length determinant protein YP_001292804.1 COG0463 Glycosyltransferases involved in cell wall biogenesis YP_001292805.1 COG1216 Predicted glycosyltransferases YP_001292807.1 COG3307 Lipid A core - O-antigen ligase and related enzymes YP_001292808.1 COG2148 Sugar transferases involved in lipopolysaccharide synthesis YP_001292809.1 COG1088 dTDP-D-glucose 4,6-dehydratase YP_001292810.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_001292811.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001292812.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001292813.1 involved in the peptidyltransferase reaction during translation YP_001292814.1 COG0261 Ribosomal protein L21 YP_001292815.1 COG0142 Geranylgeranyl pyrophosphate synthase YP_001292816.1 COG1115 Na+/alanine symporter YP_001292817.1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001292818.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001292819.1 COG2259 Predicted membrane protein YP_001292820.1 involved in de novo purine biosynthesis YP_001292821.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001292822.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001292823.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001292824.1 COG3024 Uncharacterized protein conserved in bacteria YP_001292825.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_001292827.1 COG1309 Transcriptional regulator YP_001292828.1 COG0845 Membrane-fusion protein YP_001292829.1 COG0841 Cation/multidrug efflux pump YP_001292830.1 COG3087 Cell division protein YP_001292831.1 COG1566 Multidrug resistance efflux pump YP_001292832.1 COG0262 Dihydrofolate reductase YP_001292833.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001292834.1 hydrolyzes diadenosine polyphosphate YP_001292835.1 COG0730 Predicted permeases YP_001292836.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001292837.1 COG0590 Cytosine/adenosine deaminases YP_001292839.1 COG4701 Uncharacterized protein conserved in bacteria YP_001292840.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001292841.1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_001292842.1 COG0475 Kef-type K+ transport systems, membrane components YP_001292843.1 COG0500 SAM-dependent methyltransferases YP_001292844.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001292845.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001292846.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001292847.1 COG2825 Outer membrane protein YP_001292848.1 COG4775 Outer membrane protein/protective antigen OMA87 YP_001292849.1 COG0750 Predicted membrane-associated Zn-dependent proteases 1 YP_001292851.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001292852.1 COG2980 Rare lipoprotein B YP_001292853.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001292854.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001292855.1 COG2852 Uncharacterized protein conserved in bacteria YP_001292857.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001292862.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001292876.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001292880.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_001292881.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001292882.1 required for 70S ribosome assembly YP_001292883.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001292884.1 catalyzes the formation of dUMP from dUTP YP_001292885.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_001292886.1 COG3089 Uncharacterized protein conserved in bacteria YP_001292887.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_001292888.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_001292889.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001292890.1 COG5633 Predicted periplasmic lipoprotein YP_001292891.1 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_001292892.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001292893.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001292895.1 COG0728 Uncharacterized membrane protein, putative virulence factor YP_001292898.1 COG0268 Ribosomal protein S20 YP_001292899.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001292900.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_001292901.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001292902.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001292903.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001292904.1 COG3924 Predicted membrane protein YP_001292905.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_001292906.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001292907.1 COG0042 tRNA-dihydrouridine synthase YP_001292908.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_001292909.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001292910.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001292911.1 COG0205 6-phosphofructokinase YP_001292912.1 COG3022 Uncharacterized protein conserved in bacteria YP_001292913.1 COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake YP_001292914.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001292915.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001292916.1 binds the polymerase to DNA and acts as a sliding clamp YP_001292917.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001292920.1 COG1629 Outer membrane receptor proteins, mostly Fe transport YP_001292921.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001292922.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001292923.1 COG0759 Uncharacterized conserved protein YP_001292924.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001292925.1 COG0760 Parvulin-like peptidyl-prolyl isomerase YP_001292926.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase YP_001292927.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001292928.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001292929.1 COG1555 DNA uptake protein and related DNA-binding proteins YP_001292931.1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases YP_001292932.1 COG3395 Uncharacterized protein conserved in bacteria YP_001292933.1 COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases YP_001292934.1 COG3622 Hydroxypyruvate isomerase YP_001292935.1 COG2610 H+/gluconate symporter and related permeases YP_001292936.1 COG4099 Predicted peptidase YP_001292937.1 COG1878 Predicted metal-dependent hydrolase YP_001292938.1 COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_001292939.1 COG3676 Transposase and inactivated derivatives YP_001292940.1 COG4143 ABC-type thiamine transport system, periplasmic component YP_001292941.1 COG3840 ABC-type thiamine transport system, ATPase component YP_001292942.1 COG0502 Biotin synthase and related enzymes YP_001292943.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001292944.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_001292945.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_001292946.1 COG1070 Sugar (pentulose and hexulose) kinases YP_001292947.1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component YP_001292948.1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component YP_001292949.1 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component YP_001292950.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate YP_001292951.1 COG1414 Transcriptional regulator YP_001292952.1 catalyzes the formation of serine from O-phosphoserine YP_001292953.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001292954.1 responsible for the influx of magnesium ions YP_001292955.1 COG0762 Predicted integral membrane protein YP_001292956.1 COG0121 Predicted glutamine amidotransferase YP_001292959.1 COG1373 Predicted ATPase (AAA+ superfamily) YP_001292960.1 COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain YP_001292961.1 COG1145 Ferredoxin YP_001292962.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_001292963.1 COG3302 DMSO reductase anchor subunit YP_001292964.1 COG0437 Fe-S-cluster-containing hydrogenase components 1 YP_001292965.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing YP_001292966.1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing YP_001292968.1 COG1305 Transglutaminase-like enzymes, putative cysteine proteases YP_001292969.1 COG2608 Copper chaperone YP_001292970.1 COG1132 ABC-type multidrug transport system, ATPase and permease components YP_001292971.1 COG2207 AraC-type DNA-binding domain-containing proteins YP_001292972.1 COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit YP_001292973.1 COG3421 Uncharacterized protein conserved in bacteria YP_001292974.1 COG3421 Uncharacterized protein conserved in bacteria YP_001292975.1 COG2189 Adenine specific DNA methylase Mod YP_001292976.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001292977.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001292978.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001292979.1 COG2194 Predicted membrane-associated, metal-dependent hydrolase YP_001292980.1 Catalyzes the phosphorylation of UMP to UDP YP_001292982.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_001292983.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_001292984.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_001292985.1 COG2363 Uncharacterized small membrane protein YP_001292987.1 COG2707 Predicted membrane protein YP_001292988.1 COG1294 Cytochrome bd-type quinol oxidase, subunit 2 YP_001292990.1 COG1271 Cytochrome bd-type quinol oxidase, subunit 1 YP_001292991.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001292992.1 COG3201 Nicotinamide mononucleotide transporter YP_001292993.1 COG1126 ABC-type polar amino acid transport system, ATPase component YP_001292994.1 COG0765 ABC-type amino acid transport system, permease component YP_001292995.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_001292996.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001292997.1 COG5007 Predicted transcriptional regulator, BolA superfamily YP_001292998.1 COG3113 Predicted NTP binding protein (contains STAS domain) YP_001292999.1 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component YP_001293000.1 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component YP_001293001.1 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component YP_001293002.1 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component YP_001293003.1 COG0605 Superoxide dismutase YP_001293004.1 ATP-binding protein; required for proper cytochrome c maturation YP_001293005.1 COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_001293006.1 COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_001293007.1 COG3114 Heme exporter protein D YP_001293008.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001293009.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001293010.1 COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes YP_001293014.1 COG4235 Cytochrome c biogenesis factor YP_001293015.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001293016.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_001293017.1 putative role in sulfur assimilation YP_001293018.1 COG0031 Cysteine synthase YP_001293019.1 COG0477 Permeases of the major facilitator superfamily YP_001293020.1 COG0859 ADP-heptose:LPS heptosyltransferase YP_001293021.1 COG1609 Transcriptional regulators YP_001293022.1 COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities YP_001293023.1 COG4214 ABC-type xylose transport system, permease component YP_001293024.1 with XylFH is part of the high affinity xylose ABC transporter YP_001293025.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity YP_001293026.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001293027.1 COG1070 Sugar (pentulose and hexulose) kinases YP_001293028.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_001293029.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001293030.1 COG0606 Predicted ATPase with chaperone activity YP_001293031.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001293032.1 COG2990 Uncharacterized protein conserved in bacteria YP_001293033.1 COG4608 ABC-type oligopeptide transport system, ATPase component YP_001293034.1 COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_001293035.1 COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_001293036.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_001293037.1 COG4166 ABC-type oligopeptide transport system, periplasmic component YP_001293038.1 COG0176 Transaldolase YP_001293039.1 COG0777 Acetyl-CoA carboxylase beta subunit YP_001293040.1 COG1966 Carbon starvation protein, predicted membrane protein YP_001293041.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001293042.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_001293043.1 COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_001293044.1 COG3116 Cell division protein YP_001293045.1 COG0768 Cell division protein FtsI/penicillin-binding protein 2 YP_001293046.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001293047.1 COG0770 UDP-N-acetylmuramyl pentapeptide synthase YP_001293048.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001293049.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001293050.1 COG0772 Bacterial cell division membrane protein YP_001293051.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001293052.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001293053.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001293054.1 COG1589 Cell division septal protein YP_001293055.1 COG0849 Actin-like ATPase involved in cell division YP_001293056.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001293057.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001293058.1 COG1605 Chorismate mutase YP_001293059.1 COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) YP_001293060.1 COG1137 ABC-type (unclassified) transport system, ATPase component YP_001293061.1 COG1934 Uncharacterized protein conserved in bacteria YP_001293062.1 COG3117 Uncharacterized protein conserved in bacteria YP_001293063.1 COG3028 Uncharacterized protein conserved in bacteria YP_001293064.1 COG0634 Hypoxanthine-guanine phosphoribosyltransferase YP_001293065.1 COG1280 Putative threonine efflux protein YP_001293066.1 COG1823 Predicted Na+/dicarboxylate symporter YP_001293067.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_001293068.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001293069.1 COG3118 Thioredoxin domain-containing protein YP_001293070.1 COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_001293071.1 COG2852 Uncharacterized protein conserved in bacteria YP_001293072.1 COG0277 FAD/FMN-containing dehydrogenases YP_001293073.1 COG0278 Glutaredoxin-related protein YP_001293074.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001293075.1 COG2926 Uncharacterized protein conserved in bacteria YP_001293076.1 COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase YP_001293077.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine YP_001293078.1 catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis YP_001293079.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001293080.1 COG3091 Uncharacterized protein conserved in bacteria YP_001293081.1 COG3637 Opacity protein and related surface antigens YP_001293082.1 COG5295 Autotransporter adhesin YP_001293083.1 with ArtPQJI acts to transport arginine across the inner membrane YP_001293084.1 with ArtPMJI transports arginine across the inner membrane YP_001293085.1 COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_001293086.1 With ArtMQJI transports arginine across the inner membrane YP_001293087.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_001293088.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_001293089.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_001293090.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_001293091.1 COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_001293092.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_001293093.1 COG0210 Superfamily I DNA and RNA helicases YP_001293094.1 COG0720 6-pyruvoyl-tetrahydropterin synthase YP_001293095.1 COG0603 Predicted PP-loop superfamily ATPase YP_001293096.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001293097.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_001293098.1 COG2933 Predicted SAM-dependent methyltransferase YP_001293099.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001293100.1 COG0074 Succinyl-CoA synthetase, alpha subunit YP_001293101.1 COG0009 Putative translation factor (SUA5) YP_001293102.1 COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_001293103.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_001293104.1 involved in methylation of ribosomal protein L3 YP_001293105.1 COG2840 Uncharacterized protein conserved in bacteria YP_001293106.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001293107.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001293108.1 COG1286 Uncharacterized membrane protein, required for colicin V production YP_001293109.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001293110.1 COG1090 Predicted nucleoside-diphosphate sugar epimerase YP_001293111.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001293112.1 oxidizes malate to oxaloacetate YP_001293113.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001293114.1 COG1186 Protein chain release factor B YP_001293115.1 COG1651 Protein-disulfide isomerase YP_001293116.1 COG0526 Thiol-disulfide isomerase and thioredoxins YP_001293117.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001293119.1 COG1620 L-lactate permease YP_001293120.1 COG0158 Fructose-1,6-bisphosphatase YP_001293121.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001293122.1 COG2855 Predicted membrane protein YP_001293123.1 COG4167 ABC-type antimicrobial peptide transport system, ATPase component YP_001293124.1 COG4170 ABC-type antimicrobial peptide transport system, ATPase component YP_001293125.1 COG4171 ABC-type antimicrobial peptide transport system, permease component YP_001293126.1 COG4166 ABC-type oligopeptide transport system, periplasmic component YP_001293127.1 COG3106 Predicted ATPase YP_001293128.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001293129.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_001293131.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001293134.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001293135.1 COG0586 Uncharacterized membrane-associated protein YP_001293136.1 COG3105 Uncharacterized protein conserved in bacteria YP_001293138.1 COG0790 FOG: TPR repeat, SEL1 subfamily YP_001293139.1 COG0789 Predicted transcriptional regulators YP_001293140.1 COG5266 ABC-type Co2+ transport system, periplasmic component YP_001293141.1 COG0013 Alanyl-tRNA synthetase YP_001293142.1 catalyzes the ATP-dependent transport of cobalt YP_001293143.1 COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters YP_001293144.1 COG1122 ABC-type cobalt transport system, ATPase component YP_001293145.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001293146.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001293147.1 COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase YP_001293148.1 COG4226 Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters YP_001293149.1 COG3539 P pilus assembly protein, pilin FimA YP_001293150.1 COG3121 P pilus assembly protein, chaperone PapD YP_001293151.1 COG3188 P pilus assembly protein, porin PapC YP_001293153.1 COG3539 P pilus assembly protein, pilin FimA YP_001293154.1 COG0308 Aminopeptidase N YP_001293155.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001293156.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_001293157.1 Regulatory factor involved in maltose metabolism YP_001293158.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001293159.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001293160.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001293161.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_001293162.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_001293163.1 COG3103 SH3 domain protein YP_001293164.1 COG0306 Phosphate/sulphate permeases YP_001293165.1 COG1392 Phosphate transport regulator (distant homolog of PhoU) YP_001293166.1 COG2259 Predicted membrane protein YP_001293167.1 COG3767 Uncharacterized low-complexity protein YP_001293168.1 COG3220 Uncharacterized protein conserved in bacteria YP_001293169.1 COG3219 Uncharacterized protein conserved in bacteria YP_001293170.1 COG3025 Uncharacterized conserved protein YP_001293171.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_001293172.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_001293173.1 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase YP_001293174.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001293175.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001293176.1 COG2916 DNA-binding protein H-NS YP_001293177.1 COG1757 Na+/H+ antiporter YP_001293178.1 COG0440 Acetolactate synthase, small (regulatory) subunit YP_001293179.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase