-- dump date   	20140619_104806
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
157239000001	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
157239000002	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
157239000003	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
157239000004	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
157239000005	S17 interaction site [polypeptide binding]; other site
157239000006	S8 interaction site; other site
157239000007	16S rRNA interaction site [nucleotide binding]; other site
157239000008	streptomycin interaction site [chemical binding]; other site
157239000009	23S rRNA interaction site [nucleotide binding]; other site
157239000010	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
157239000011	30S ribosomal protein S7; Validated; Region: PRK05302
157239000012	elongation factor G; Reviewed; Region: PRK00007
157239000013	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
157239000014	G1 box; other site
157239000015	putative GEF interaction site [polypeptide binding]; other site
157239000016	GTP/Mg2+ binding site [chemical binding]; other site
157239000017	Switch I region; other site
157239000018	G2 box; other site
157239000019	G3 box; other site
157239000020	Switch II region; other site
157239000021	G4 box; other site
157239000022	G5 box; other site
157239000023	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
157239000024	Elongation Factor G, domain II; Region: EFG_II; pfam14492
157239000025	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
157239000026	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
157239000027	elongation factor Tu; Reviewed; Region: PRK00049
157239000028	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
157239000029	G1 box; other site
157239000030	GEF interaction site [polypeptide binding]; other site
157239000031	GTP/Mg2+ binding site [chemical binding]; other site
157239000032	Switch I region; other site
157239000033	G2 box; other site
157239000034	G3 box; other site
157239000035	Switch II region; other site
157239000036	G4 box; other site
157239000037	G5 box; other site
157239000038	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
157239000039	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
157239000040	Antibiotic Binding Site [chemical binding]; other site
157239000041	Uncharacterized conserved protein involved in oxidation of intracellular sulfur [Inorganic ion transport and metabolism]; Region: DsrH; COG2168
157239000042	sulfur relay protein TusC; Validated; Region: PRK00211
157239000043	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
157239000044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
157239000045	YheO-like PAS domain; Region: PAS_6; pfam08348
157239000046	HTH domain; Region: HTH_22; pfam13309
157239000047	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
157239000048	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
157239000049	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
157239000050	hypothetical protein; Provisional; Region: PRK02119
157239000051	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
157239000052	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
157239000053	catalytic triad [active]
157239000054	dimer interface [polypeptide binding]; other site
157239000055	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
157239000056	GSH binding site [chemical binding]; other site
157239000057	catalytic residues [active]
157239000058	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
157239000059	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
157239000060	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
157239000061	dimerization interface [polypeptide binding]; other site
157239000062	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
157239000063	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
157239000064	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
157239000065	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
157239000066	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
157239000067	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
157239000068	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
157239000069	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
157239000070	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
157239000071	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
157239000072	RNA binding site [nucleotide binding]; other site
157239000073	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
157239000074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
157239000075	ATP binding site [chemical binding]; other site
157239000076	Mg2+ binding site [ion binding]; other site
157239000077	G-X-G motif; other site
157239000078	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
157239000079	anchoring element; other site
157239000080	dimer interface [polypeptide binding]; other site
157239000081	ATP binding site [chemical binding]; other site
157239000082	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
157239000083	active site
157239000084	putative metal-binding site [ion binding]; other site
157239000085	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
157239000086	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
157239000087	substrate binding site [chemical binding]; other site
157239000088	hexamer interface [polypeptide binding]; other site
157239000089	metal binding site [ion binding]; metal-binding site
157239000090	phosphoglycolate phosphatase; Provisional; Region: PRK13222
157239000091	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
157239000092	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
157239000093	motif II; other site
157239000094	aspartate--ammonia ligase, AsnA-type; Region: asnA; TIGR00669
157239000095	motif 1; other site
157239000096	dimer interface [polypeptide binding]; other site
157239000097	active site
157239000098	motif 2; other site
157239000099	motif 3; other site
157239000100	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
157239000101	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
157239000102	dimerization interface [polypeptide binding]; other site
157239000103	putative DNA binding site [nucleotide binding]; other site
157239000104	putative Zn2+ binding site [ion binding]; other site
157239000105	AsnC family; Region: AsnC_trans_reg; pfam01037
157239000106	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
157239000107	RNA binding surface [nucleotide binding]; other site
157239000108	putative oligopeptide transporter, OPT family; Region: TIGR00733
157239000109	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
157239000110	active site
157239000111	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
157239000112	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
157239000113	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
157239000114	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
157239000115	putative active site [active]
157239000116	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
157239000117	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
157239000118	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
157239000119	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
157239000120	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786
157239000121	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
157239000122	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
157239000123	active site
157239000124	metal binding site [ion binding]; metal-binding site
157239000125	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
157239000126	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
157239000127	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
157239000128	rRNA binding site [nucleotide binding]; other site
157239000129	predicted 30S ribosome binding site; other site
157239000130	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
157239000131	primosomal replication protein N; Provisional; Region: PRK02801
157239000132	generic binding surface I; other site
157239000133	generic binding surface II; other site
157239000134	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
157239000135	ribosomal protein L9; Region: L9; TIGR00158
157239000136	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
157239000137	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
157239000138	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
157239000139	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
157239000140	ring oligomerisation interface [polypeptide binding]; other site
157239000141	ATP/Mg binding site [chemical binding]; other site
157239000142	stacking interactions; other site
157239000143	hinge regions; other site
157239000144	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
157239000145	oligomerisation interface [polypeptide binding]; other site
157239000146	mobile loop; other site
157239000147	roof hairpin; other site
157239000148	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
157239000149	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
157239000150	Aspartase; Region: Aspartase; cd01357
157239000151	active sites [active]
157239000152	tetramer interface [polypeptide binding]; other site
157239000153	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
157239000154	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
157239000155	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
157239000156	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
157239000157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
157239000158	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
157239000159	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
157239000160	DNA binding residues [nucleotide binding]
157239000161	DNA primase; Validated; Region: dnaG; PRK05667
157239000162	CHC2 zinc finger; Region: zf-CHC2; pfam01807
157239000163	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
157239000164	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
157239000165	active site
157239000166	metal binding site [ion binding]; metal-binding site
157239000167	interdomain interaction site; other site
157239000168	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
157239000169	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
157239000170	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
157239000171	UGMP family protein; Validated; Region: PRK09604
157239000172	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
157239000173	nucleotide binding site [chemical binding]; other site
157239000174	thymidine kinase; Provisional; Region: PRK04296
157239000175	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
157239000176	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
157239000177	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
157239000178	Ribonuclease I [Translation, ribosomal structure and biogenesis]; Region: Rna; COG3719
157239000179	CAS motifs; other site
157239000180	active site
157239000181	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
157239000182	substrate binding site [chemical binding]; other site
157239000183	hinge regions; other site
157239000184	ADP binding site [chemical binding]; other site
157239000185	catalytic site [active]
157239000186	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
157239000187	active site
157239000188	intersubunit interface [polypeptide binding]; other site
157239000189	zinc binding site [ion binding]; other site
157239000190	Na+ binding site [ion binding]; other site
157239000191	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
157239000192	putative active site [active]
157239000193	Predicted membrane protein [Function unknown]; Region: COG2364
157239000194	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
157239000195	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
157239000196	glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040
157239000197	Pyruvate formate lyase; Region: PFL; pfam02901
157239000198	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
157239000199	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239000200	FeS/SAM binding site; other site
157239000201	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
157239000202	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
157239000203	Nucleoside recognition; Region: Gate; pfam07670
157239000204	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
157239000205	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
157239000206	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
157239000207	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
157239000208	23S rRNA interface [nucleotide binding]; other site
157239000209	L7/L12 interface [polypeptide binding]; other site
157239000210	putative thiostrepton binding site; other site
157239000211	L25 interface [polypeptide binding]; other site
157239000212	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
157239000213	mRNA/rRNA interface [nucleotide binding]; other site
157239000214	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
157239000215	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
157239000216	RPB12 interaction site [polypeptide binding]; other site
157239000217	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478
157239000218	RPB1 interaction site [polypeptide binding]; other site
157239000219	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
157239000220	RPB10 interaction site [polypeptide binding]; other site
157239000221	RPB11 interaction site [polypeptide binding]; other site
157239000222	RPB3 interaction site [polypeptide binding]; other site
157239000223	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
157239000224	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
157239000225	beta and beta' interface [polypeptide binding]; other site
157239000226	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
157239000227	beta' and sigma factor interface [polypeptide binding]; other site
157239000228	Zn-binding [ion binding]; other site
157239000229	active site region [active]
157239000230	catalytic site [active]
157239000231	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
157239000232	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
157239000233	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
157239000234	G-loop; other site
157239000235	DNA binding site [nucleotide binding]
157239000236	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
157239000237	gating phenylalanine in ion channel; other site
157239000238	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
157239000239	homodimer interaction site [polypeptide binding]; other site
157239000240	cofactor binding site; other site
157239000241	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
157239000242	putative active site [active]
157239000243	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
157239000244	hypothetical protein; Provisional; Region: PRK05208
157239000245	transcriptional repressor RbsR; Provisional; Region: PRK10423
157239000246	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
157239000247	DNA binding site [nucleotide binding]
157239000248	domain linker motif; other site
157239000249	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
157239000250	dimerization interface [polypeptide binding]; other site
157239000251	ligand binding site [chemical binding]; other site
157239000252	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
157239000253	substrate binding site [chemical binding]; other site
157239000254	dimer interface [polypeptide binding]; other site
157239000255	ATP binding site [chemical binding]; other site
157239000256	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
157239000257	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
157239000258	ligand binding site [chemical binding]; other site
157239000259	dimerization interface [polypeptide binding]; other site
157239000260	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
157239000261	TM-ABC transporter signature motif; other site
157239000262	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
157239000263	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
157239000264	Walker A/P-loop; other site
157239000265	ATP binding site [chemical binding]; other site
157239000266	Q-loop/lid; other site
157239000267	ABC transporter signature motif; other site
157239000268	Walker B; other site
157239000269	D-loop; other site
157239000270	H-loop/switch region; other site
157239000271	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
157239000272	D-ribose pyranase; Provisional; Region: PRK11797
157239000273	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
157239000274	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
157239000275	RmuC family; Region: RmuC; pfam02646
157239000276	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
157239000277	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
157239000278	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
157239000279	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
157239000280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239000281	Walker A motif; other site
157239000282	ATP binding site [chemical binding]; other site
157239000283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239000284	Walker B motif; other site
157239000285	arginine finger; other site
157239000286	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
157239000287	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
157239000288	active site
157239000289	HslU subunit interaction site [polypeptide binding]; other site
157239000290	Acid phosphatase (class B) [General function prediction only]; Region: AphA; COG3700
157239000291	Integrase core domain; Region: rve; pfam00665
157239000292	Integrase core domain; Region: rve_3; cl15866
157239000293	S-ribosylhomocysteinase; Provisional; Region: PRK02260
157239000294	Predicted membrane protein [Function unknown]; Region: COG1238
157239000295	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
157239000296	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
157239000297	motif II; other site
157239000298	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
157239000299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239000300	S-adenosylmethionine binding site [chemical binding]; other site
157239000301	F0F1 ATP synthase subunit I; Validated; Region: PRK06099
157239000302	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
157239000303	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
157239000304	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
157239000305	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
157239000306	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
157239000307	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
157239000308	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
157239000309	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
157239000310	beta subunit interaction interface [polypeptide binding]; other site
157239000311	Walker A motif; other site
157239000312	ATP binding site [chemical binding]; other site
157239000313	Walker B motif; other site
157239000314	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
157239000315	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
157239000316	core domain interface [polypeptide binding]; other site
157239000317	delta subunit interface [polypeptide binding]; other site
157239000318	epsilon subunit interface [polypeptide binding]; other site
157239000319	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
157239000320	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
157239000321	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
157239000322	alpha subunit interaction interface [polypeptide binding]; other site
157239000323	Walker A motif; other site
157239000324	ATP binding site [chemical binding]; other site
157239000325	Walker B motif; other site
157239000326	inhibitor binding site; inhibition site
157239000327	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
157239000328	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
157239000329	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
157239000330	gamma subunit interface [polypeptide binding]; other site
157239000331	epsilon subunit interface [polypeptide binding]; other site
157239000332	LBP interface [polypeptide binding]; other site
157239000333	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
157239000334	aromatic amino acid transport protein; Region: araaP; TIGR00837
157239000335	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
157239000336	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
157239000337	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
157239000338	metal binding site [ion binding]; metal-binding site
157239000339	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
157239000340	substrate binding site [chemical binding]; other site
157239000341	glutamase interaction surface [polypeptide binding]; other site
157239000342	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
157239000343	catalytic residues [active]
157239000344	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
157239000345	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
157239000346	putative active site [active]
157239000347	oxyanion strand; other site
157239000348	catalytic triad [active]
157239000349	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
157239000350	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
157239000351	active site
157239000352	motif I; other site
157239000353	motif II; other site
157239000354	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
157239000355	putative active site pocket [active]
157239000356	4-fold oligomerization interface [polypeptide binding]; other site
157239000357	metal binding residues [ion binding]; metal-binding site
157239000358	3-fold/trimer interface [polypeptide binding]; other site
157239000359	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
157239000360	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
157239000361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239000362	homodimer interface [polypeptide binding]; other site
157239000363	catalytic residue [active]
157239000364	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
157239000365	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
157239000366	NAD binding site [chemical binding]; other site
157239000367	dimerization interface [polypeptide binding]; other site
157239000368	product binding site; other site
157239000369	substrate binding site [chemical binding]; other site
157239000370	zinc binding site [ion binding]; other site
157239000371	catalytic residues [active]
157239000372	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
157239000373	ATP phosphoribosyltransferase; Region: HisG; pfam01634
157239000374	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
157239000375	hypothetical protein; Provisional; Region: PRK11820
157239000376	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
157239000377	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
157239000378	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
157239000379	Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893
157239000380	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
157239000381	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
157239000382	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
157239000383	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
157239000384	ligand binding site [chemical binding]; other site
157239000385	NAD binding site [chemical binding]; other site
157239000386	tetramer interface [polypeptide binding]; other site
157239000387	catalytic site [active]
157239000388	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
157239000389	L-serine binding site [chemical binding]; other site
157239000390	ACT domain interface; other site
157239000391	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
157239000392	tetramer (dimer of dimers) interface [polypeptide binding]; other site
157239000393	active site
157239000394	dimer interface [polypeptide binding]; other site
157239000395	HemN family oxidoreductase; Provisional; Region: PRK05660
157239000396	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239000397	FeS/SAM binding site; other site
157239000398	HemN C-terminal domain; Region: HemN_C; pfam06969
157239000399	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
157239000400	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
157239000401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239000402	Walker A motif; other site
157239000403	ATP binding site [chemical binding]; other site
157239000404	Walker B motif; other site
157239000405	arginine finger; other site
157239000406	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
157239000407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
157239000408	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
157239000409	homodimer interface [polypeptide binding]; other site
157239000410	MazG family protein; Region: mazG; TIGR00444
157239000411	metal binding site [ion binding]; metal-binding site
157239000412	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
157239000413	homodimer interface [polypeptide binding]; other site
157239000414	active site
157239000415	putative chemical substrate binding site [chemical binding]; other site
157239000416	metal binding site [ion binding]; metal-binding site
157239000417	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239000418	active site
157239000419	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
157239000420	SurA N-terminal domain; Region: SurA_N; pfam09312
157239000421	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
157239000422	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
157239000423	dimerization interface [polypeptide binding]; other site
157239000424	thymidylate kinase; Validated; Region: tmk; PRK00698
157239000425	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
157239000426	TMP-binding site; other site
157239000427	ATP-binding site [chemical binding]; other site
157239000428	DNA polymerase III subunit delta'; Validated; Region: PRK06871
157239000429	DNA polymerase III subunit delta'; Validated; Region: PRK08485
157239000430	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
157239000431	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
157239000432	active site
157239000433	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
157239000434	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
157239000435	Domain of unknown function DUF21; Region: DUF21; pfam01595
157239000436	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
157239000437	Transporter associated domain; Region: CorC_HlyC; smart01091
157239000438	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
157239000439	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779
157239000440	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
157239000441	active site
157239000442	phosphorylation site [posttranslational modification]
157239000443	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
157239000444	dimerization domain swap beta strand [polypeptide binding]; other site
157239000445	regulatory protein interface [polypeptide binding]; other site
157239000446	active site
157239000447	regulatory phosphorylation site [posttranslational modification]; other site
157239000448	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
157239000449	dimerization domain swap beta strand [polypeptide binding]; other site
157239000450	regulatory protein interface [polypeptide binding]; other site
157239000451	active site
157239000452	regulatory phosphorylation site [posttranslational modification]; other site
157239000453	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
157239000454	putative substrate binding site [chemical binding]; other site
157239000455	putative ATP binding site [chemical binding]; other site
157239000456	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
157239000457	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
157239000458	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
157239000459	active site
157239000460	P-loop; other site
157239000461	phosphorylation site [posttranslational modification]
157239000462	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
157239000463	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
157239000464	DNA topoisomerase III; Provisional; Region: PRK07726
157239000465	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
157239000466	active site
157239000467	putative interdomain interaction site [polypeptide binding]; other site
157239000468	putative metal-binding site [ion binding]; other site
157239000469	putative nucleotide binding site [chemical binding]; other site
157239000470	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
157239000471	domain I; other site
157239000472	DNA binding groove [nucleotide binding]
157239000473	phosphate binding site [ion binding]; other site
157239000474	domain II; other site
157239000475	domain III; other site
157239000476	nucleotide binding site [chemical binding]; other site
157239000477	catalytic site [active]
157239000478	domain IV; other site
157239000479	recombination protein RecR; Reviewed; Region: recR; PRK00076
157239000480	RecR protein; Region: RecR; pfam02132
157239000481	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
157239000482	putative active site [active]
157239000483	putative metal-binding site [ion binding]; other site
157239000484	tetramer interface [polypeptide binding]; other site
157239000485	hypothetical protein; Validated; Region: PRK00153
157239000486	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
157239000487	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
157239000488	Transglycosylase; Region: Transgly; pfam00912
157239000489	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
157239000490	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
157239000491	Pilus assembly protein, PilP; Region: PilP; cl19831
157239000492	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
157239000493	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
157239000494	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
157239000495	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
157239000496	zinc-ribbons; Region: zinc-ribbons_6; pfam07191
157239000497	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239000498	active site
157239000499	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
157239000500	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
157239000501	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
157239000502	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
157239000503	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
157239000504	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
157239000505	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
157239000506	putative NADH binding site [chemical binding]; other site
157239000507	putative active site [active]
157239000508	nudix motif; other site
157239000509	putative metal binding site [ion binding]; other site
157239000510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
157239000511	histone-like DNA-binding protein HU; Region: HU; cd13831
157239000512	dimer interface [polypeptide binding]; other site
157239000513	DNA binding site [nucleotide binding]
157239000514	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
157239000515	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
157239000516	glutaminase active site [active]
157239000517	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
157239000518	dimer interface [polypeptide binding]; other site
157239000519	active site
157239000520	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
157239000521	dimer interface [polypeptide binding]; other site
157239000522	active site
157239000523	disulfide bond formation protein B; Provisional; Region: PRK01749
157239000524	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
157239000525	fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812
157239000526	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
157239000527	DNA-binding site [nucleotide binding]; DNA binding site
157239000528	FadR C-terminal domain; Region: FadR_C; pfam07840
157239000529	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
157239000530	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
157239000531	domain interface [polypeptide binding]; other site
157239000532	putative active site [active]
157239000533	catalytic site [active]
157239000534	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
157239000535	domain interface [polypeptide binding]; other site
157239000536	putative active site [active]
157239000537	catalytic site [active]
157239000538	putative methyltransferase; Provisional; Region: PRK10864
157239000539	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
157239000540	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
157239000541	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
157239000542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239000543	S-adenosylmethionine binding site [chemical binding]; other site
157239000544	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
157239000545	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
157239000546	ATP binding site [chemical binding]; other site
157239000547	Mg++ binding site [ion binding]; other site
157239000548	motif III; other site
157239000549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239000550	nucleotide binding region [chemical binding]; other site
157239000551	ATP-binding site [chemical binding]; other site
157239000552	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
157239000553	putative protease; Provisional; Region: PRK15452
157239000554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239000555	metabolite-proton symporter; Region: 2A0106; TIGR00883
157239000556	putative substrate translocation pore; other site
157239000557	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
157239000558	thiamine phosphate binding site [chemical binding]; other site
157239000559	active site
157239000560	pyrophosphate binding site [ion binding]; other site
157239000561	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
157239000562	dimer interface [polypeptide binding]; other site
157239000563	substrate binding site [chemical binding]; other site
157239000564	ATP binding site [chemical binding]; other site
157239000565	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
157239000566	substrate binding site [chemical binding]; other site
157239000567	multimerization interface [polypeptide binding]; other site
157239000568	ATP binding site [chemical binding]; other site
157239000569	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
157239000570	ribonuclease E; Reviewed; Region: rne; PRK10811
157239000571	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
157239000572	homodimer interface [polypeptide binding]; other site
157239000573	oligonucleotide binding site [chemical binding]; other site
157239000574	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
157239000575	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
157239000576	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
157239000577	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
157239000578	RNA binding surface [nucleotide binding]; other site
157239000579	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
157239000580	active site
157239000581	bacterial Hfq-like; Region: Hfq; cd01716
157239000582	hexamer interface [polypeptide binding]; other site
157239000583	Sm1 motif; other site
157239000584	RNA binding site [nucleotide binding]; other site
157239000585	Sm2 motif; other site
157239000586	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
157239000587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239000588	Walker A motif; other site
157239000589	ATP binding site [chemical binding]; other site
157239000590	Walker B motif; other site
157239000591	arginine finger; other site
157239000592	putative peptidase; Provisional; Region: PRK11649
157239000593	Peptidase family M23; Region: Peptidase_M23; pfam01551
157239000594	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
157239000595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239000596	Walker A/P-loop; other site
157239000597	ATP binding site [chemical binding]; other site
157239000598	Q-loop/lid; other site
157239000599	ABC transporter signature motif; other site
157239000600	Walker B; other site
157239000601	D-loop; other site
157239000602	H-loop/switch region; other site
157239000603	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
157239000604	ABC-ATPase subunit  interface; other site
157239000605	dimer interface [polypeptide binding]; other site
157239000606	putative PBP binding regions; other site
157239000607	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
157239000608	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
157239000609	dimer interface [polypeptide binding]; other site
157239000610	pyridoxal binding site [chemical binding]; other site
157239000611	ATP binding site [chemical binding]; other site
157239000612	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
157239000613	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
157239000614	Ligand Binding Site [chemical binding]; other site
157239000615	TilS substrate binding domain; Region: TilS; pfam09179
157239000616	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
157239000617	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
157239000618	putative DNA-binding cleft [nucleotide binding]; other site
157239000619	putative DNA clevage site; other site
157239000620	molecular lever; other site
157239000621	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
157239000622	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
157239000623	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
157239000624	DNA binding site [nucleotide binding]
157239000625	active site
157239000626	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
157239000627	conserved hypothetical protein; Region: TIGR00743
157239000628	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
157239000629	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
157239000630	active site
157239000631	metal binding site [ion binding]; metal-binding site
157239000632	hexamer interface [polypeptide binding]; other site
157239000633	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
157239000634	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
157239000635	dimer interface [polypeptide binding]; other site
157239000636	ADP-ribose binding site [chemical binding]; other site
157239000637	active site
157239000638	nudix motif; other site
157239000639	metal binding site [ion binding]; metal-binding site
157239000640	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
157239000641	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
157239000642	generic binding surface II; other site
157239000643	generic binding surface I; other site
157239000644	Uncharacterized conserved protein [Function unknown]; Region: COG2850
157239000645	hypothetical protein; Validated; Region: PRK01777
157239000646	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
157239000647	putative active site [active]
157239000648	catalytic residue [active]
157239000649	GTP-binding protein YchF; Reviewed; Region: PRK09601
157239000650	YchF GTPase; Region: YchF; cd01900
157239000651	G1 box; other site
157239000652	GTP/Mg2+ binding site [chemical binding]; other site
157239000653	Switch I region; other site
157239000654	G2 box; other site
157239000655	Switch II region; other site
157239000656	G3 box; other site
157239000657	G4 box; other site
157239000658	G5 box; other site
157239000659	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
157239000660	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
157239000661	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
157239000662	catalytic site [active]
157239000663	putative active site [active]
157239000664	putative substrate binding site [chemical binding]; other site
157239000665	Helicase and RNase D C-terminal; Region: HRDC; smart00341
157239000666	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
157239000667	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
157239000668	acyl-activating enzyme (AAE) consensus motif; other site
157239000669	putative AMP binding site [chemical binding]; other site
157239000670	putative active site [active]
157239000671	putative CoA binding site [chemical binding]; other site
157239000672	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
157239000673	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
157239000674	Glycoprotease family; Region: Peptidase_M22; pfam00814
157239000675	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
157239000676	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708
157239000677	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
157239000678	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
157239000679	active site
157239000680	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
157239000681	colicin uptake protein TolR; Provisional; Region: PRK11024
157239000682	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
157239000683	TolA C-terminal; Region: TolA; pfam06519
157239000684	translocation protein TolB; Provisional; Region: tolB; PRK01742
157239000685	TolB amino-terminal domain; Region: TolB_N; pfam04052
157239000686	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
157239000687	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
157239000688	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
157239000689	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
157239000690	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
157239000691	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
157239000692	ligand binding site [chemical binding]; other site
157239000693	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
157239000694	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
157239000695	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
157239000696	Rrf2 family protein; Region: rrf2_super; TIGR00738
157239000697	cysteine desulfurase; Provisional; Region: PRK14012
157239000698	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
157239000699	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
157239000700	catalytic residue [active]
157239000701	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
157239000702	trimerization site [polypeptide binding]; other site
157239000703	active site
157239000704	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
157239000705	co-chaperone HscB; Provisional; Region: hscB; PRK01773
157239000706	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
157239000707	HSP70 interaction site [polypeptide binding]; other site
157239000708	HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743
157239000709	Protein of unknown function DUF2625; Region: DUF2625; pfam10946
157239000710	chaperone protein HscA; Provisional; Region: hscA; PRK05183
157239000711	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
157239000712	nucleotide binding site [chemical binding]; other site
157239000713	putative NEF/HSP70 interaction site [polypeptide binding]; other site
157239000714	SBD interface [polypeptide binding]; other site
157239000715	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
157239000716	catalytic loop [active]
157239000717	iron binding site [ion binding]; other site
157239000718	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
157239000719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
157239000720	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
157239000721	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
157239000722	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
157239000723	dimer interface [polypeptide binding]; other site
157239000724	motif 1; other site
157239000725	active site
157239000726	motif 2; other site
157239000727	motif 3; other site
157239000728	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
157239000729	anticodon binding site; other site
157239000730	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
157239000731	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
157239000732	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
157239000733	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239000734	non-specific DNA binding site [nucleotide binding]; other site
157239000735	salt bridge; other site
157239000736	sequence-specific DNA binding site [nucleotide binding]; other site
157239000737	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
157239000738	TPR repeat; Region: TPR_11; pfam13414
157239000739	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
157239000740	binding surface
157239000741	TPR motif; other site
157239000742	TPR repeat; Region: TPR_11; pfam13414
157239000743	23S rRNA m2A2503 methyltransferase; Region: TIGR00048
157239000744	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239000745	FeS/SAM binding site; other site
157239000746	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
157239000747	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
157239000748	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
157239000749	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
157239000750	Probable transposase; Region: OrfB_IS605; pfam01385
157239000751	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
157239000752	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
157239000753	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
157239000754	metal binding site [ion binding]; metal-binding site
157239000755	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
157239000756	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
157239000757	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
157239000758	ABC-ATPase subunit  interface; other site
157239000759	dimer interface [polypeptide binding]; other site
157239000760	putative PBP binding regions; other site
157239000761	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
157239000762	ABC-ATPase subunit  interface; other site
157239000763	dimer interface [polypeptide binding]; other site
157239000764	putative PBP binding regions; other site
157239000765	Putative transcription activator [Transcription]; Region: TenA; COG0819
157239000766	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
157239000767	NMT1/THI5 like; Region: NMT1; pfam09084
157239000768	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
157239000769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239000770	dimer interface [polypeptide binding]; other site
157239000771	conserved gate region; other site
157239000772	putative PBP binding loops; other site
157239000773	ABC-ATPase subunit interface; other site
157239000774	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
157239000775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239000776	Walker A/P-loop; other site
157239000777	ATP binding site [chemical binding]; other site
157239000778	Q-loop/lid; other site
157239000779	ABC transporter signature motif; other site
157239000780	Walker B; other site
157239000781	D-loop; other site
157239000782	H-loop/switch region; other site
157239000783	Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002
157239000784	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
157239000785	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
157239000786	NAD binding site [chemical binding]; other site
157239000787	homodimer interface [polypeptide binding]; other site
157239000788	active site
157239000789	substrate binding site [chemical binding]; other site
157239000790	Major Facilitator Superfamily; Region: MFS_1; pfam07690
157239000791	AmpG-like permease; Region: 2A0125; TIGR00901
157239000792	adenylate kinase; Reviewed; Region: adk; PRK00279
157239000793	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
157239000794	AMP-binding site [chemical binding]; other site
157239000795	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
157239000796	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
157239000797	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
157239000798	Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043
157239000799	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
157239000800	4Fe-4S binding domain; Region: Fer4_5; pfam12801
157239000801	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
157239000802	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
157239000803	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
157239000804	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
157239000805	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
157239000806	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
157239000807	[4Fe-4S] binding site [ion binding]; other site
157239000808	molybdopterin cofactor binding site; other site
157239000809	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
157239000810	molybdopterin cofactor binding site; other site
157239000811	Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062
157239000812	ferredoxin-type protein NapF; Region: napF; TIGR00402
157239000813	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
157239000814	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
157239000815	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
157239000816	hypothetical protein; Provisional; Region: PRK11702
157239000817	tRNA (guanine-N(7)-)-methyltransferase; Region: TIGR00091
157239000818	primosome assembly protein PriA; Validated; Region: PRK05580
157239000819	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239000820	ATP binding site [chemical binding]; other site
157239000821	putative Mg++ binding site [ion binding]; other site
157239000822	helicase superfamily c-terminal domain; Region: HELICc; smart00490
157239000823	Domain of unknown function DUF20; Region: UPF0118; cl00465
157239000824	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
157239000825	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
157239000826	MPT binding site; other site
157239000827	trimer interface [polypeptide binding]; other site
157239000828	Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264
157239000829	putative active site [active]
157239000830	trimer interface [polypeptide binding]; other site
157239000831	putative active site [active]
157239000832	Zn binding site [ion binding]; other site
157239000833	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
157239000834	HD domain; Region: HD_4; pfam13328
157239000835	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
157239000836	synthetase active site [active]
157239000837	NTP binding site [chemical binding]; other site
157239000838	metal binding site [ion binding]; metal-binding site
157239000839	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
157239000840	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
157239000841	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
157239000842	TRAM domain; Region: TRAM; pfam01938
157239000843	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239000844	S-adenosylmethionine binding site [chemical binding]; other site
157239000845	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
157239000846	Recombination protein O N terminal; Region: RecO_N; pfam11967
157239000847	Recombination protein O C terminal; Region: RecO_C; pfam02565
157239000848	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
157239000849	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
157239000850	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
157239000851	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
157239000852	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239000853	FeS/SAM binding site; other site
157239000854	elongation factor P; Validated; Region: PRK00529
157239000855	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
157239000856	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
157239000857	RNA binding site [nucleotide binding]; other site
157239000858	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
157239000859	RNA binding site [nucleotide binding]; other site
157239000860	Primosomal replication protein N'' [DNA replication, recombination, and repair]; Region: PriC; COG3923
157239000861	Predicted permease [General function prediction only]; Region: COG2056
157239000862	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
157239000863	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
157239000864	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
157239000865	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
157239000866	dimer interface [polypeptide binding]; other site
157239000867	catalytic site [active]
157239000868	putative active site [active]
157239000869	putative substrate binding site [chemical binding]; other site
157239000870	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
157239000871	dimer interface [polypeptide binding]; other site
157239000872	active site
157239000873	metal binding site [ion binding]; metal-binding site
157239000874	glutathione binding site [chemical binding]; other site
157239000875	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
157239000876	oligomeric interface; other site
157239000877	putative active site [active]
157239000878	homodimer interface [polypeptide binding]; other site
157239000879	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
157239000880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239000881	S-adenosylmethionine binding site [chemical binding]; other site
157239000882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
157239000883	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
157239000884	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
157239000885	dimer interface [polypeptide binding]; other site
157239000886	anticodon binding site; other site
157239000887	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
157239000888	homodimer interface [polypeptide binding]; other site
157239000889	motif 1; other site
157239000890	active site
157239000891	motif 2; other site
157239000892	GAD domain; Region: GAD; pfam02938
157239000893	motif 3; other site
157239000894	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
157239000895	nudix motif; other site
157239000896	hypothetical protein; Validated; Region: PRK00110
157239000897	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
157239000898	active site
157239000899	putative DNA-binding cleft [nucleotide binding]; other site
157239000900	dimer interface [polypeptide binding]; other site
157239000901	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
157239000902	RuvA N terminal domain; Region: RuvA_N; pfam01330
157239000903	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
157239000904	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
157239000905	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
157239000906	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239000907	Walker A motif; other site
157239000908	ATP binding site [chemical binding]; other site
157239000909	Walker B motif; other site
157239000910	arginine finger; other site
157239000911	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
157239000912	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
157239000913	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
157239000914	active site
157239000915	Int/Topo IB signature motif; other site
157239000916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239000917	Major Facilitator Superfamily; Region: MFS_1; pfam07690
157239000918	putative substrate translocation pore; other site
157239000919	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
157239000920	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
157239000921	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
157239000922	Replicase family; Region: Replicase; pfam03090
157239000923	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
157239000924	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
157239000925	Helix-turn-helix domain; Region: HTH_17; cl17695
157239000926	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
157239000927	GIY-YIG motif/motif A; other site
157239000928	putative active site [active]
157239000929	putative metal binding site [ion binding]; other site
157239000930	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239000931	non-specific DNA binding site [nucleotide binding]; other site
157239000932	salt bridge; other site
157239000933	sequence-specific DNA binding site [nucleotide binding]; other site
157239000934	integrase; Provisional; Region: PRK09692
157239000935	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
157239000936	active site
157239000937	Int/Topo IB signature motif; other site
157239000938	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
157239000939	RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250
157239000940	Putative transcriptional regulator [Transcription]; Region: COG1678
157239000941	RNA methyltransferase, RsmE family; Region: TIGR00046
157239000942	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
157239000943	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167
157239000944	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
157239000945	putative active site [active]
157239000946	catalytic triad [active]
157239000947	putative dimer interface [polypeptide binding]; other site
157239000948	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
157239000949	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
157239000950	Transporter associated domain; Region: CorC_HlyC; smart01091
157239000951	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
157239000952	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
157239000953	amidase catalytic site [active]
157239000954	Zn binding residues [ion binding]; other site
157239000955	substrate binding site [chemical binding]; other site
157239000956	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
157239000957	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
157239000958	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
157239000959	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
157239000960	Walker A motif; other site
157239000961	ATP binding site [chemical binding]; other site
157239000962	Walker B motif; other site
157239000963	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
157239000964	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
157239000965	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
157239000966	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
157239000967	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
157239000968	transcription termination factor Rho; Provisional; Region: rho; PRK09376
157239000969	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
157239000970	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
157239000971	RNA binding site [nucleotide binding]; other site
157239000972	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
157239000973	multimer interface [polypeptide binding]; other site
157239000974	Walker A motif; other site
157239000975	ATP binding site [chemical binding]; other site
157239000976	Walker B motif; other site
157239000977	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
157239000978	dimerization interface [polypeptide binding]; other site
157239000979	DNA binding site [nucleotide binding]
157239000980	corepressor binding sites; other site
157239000981	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
157239000982	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
157239000983	DNA binding residues [nucleotide binding]
157239000984	dimer interface [polypeptide binding]; other site
157239000985	copper binding site [ion binding]; other site
157239000986	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
157239000987	metal-binding site [ion binding]
157239000988	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
157239000989	metal-binding site [ion binding]
157239000990	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
157239000991	metal-binding site [ion binding]
157239000992	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
157239000993	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
157239000994	metal-binding site [ion binding]
157239000995	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
157239000996	Soluble P-type ATPase [General function prediction only]; Region: COG4087
157239000997	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
157239000998	serine transporter; Region: stp; TIGR00814
157239000999	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
157239001000	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
157239001001	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
157239001002	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
157239001003	aromatic amino acid transport protein; Region: araaP; TIGR00837
157239001004	aminotransferase AlaT; Validated; Region: PRK09265
157239001005	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
157239001006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239001007	homodimer interface [polypeptide binding]; other site
157239001008	catalytic residue [active]
157239001009	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
157239001010	isochorismate synthases; Region: isochor_syn; TIGR00543
157239001011	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
157239001012	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
157239001013	dimer interface [polypeptide binding]; other site
157239001014	tetramer interface [polypeptide binding]; other site
157239001015	PYR/PP interface [polypeptide binding]; other site
157239001016	TPP binding site [chemical binding]; other site
157239001017	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
157239001018	TPP-binding site; other site
157239001019	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
157239001020	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
157239001021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239001022	metabolite-proton symporter; Region: 2A0106; TIGR00883
157239001023	putative substrate translocation pore; other site
157239001024	uridine phosphorylase; Provisional; Region: PRK11178
157239001025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
157239001026	MOSC domain; Region: MOSC; pfam03473
157239001027	3-alpha domain; Region: 3-alpha; pfam03475
157239001028	hypothetical protein; Provisional; Region: PRK01752
157239001029	SEC-C motif; Region: SEC-C; cl19389
157239001030	SEC-C motif; Region: SEC-C; pfam02810
157239001031	hypothetical protein; Reviewed; Region: PRK01637
157239001032	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
157239001033	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
157239001034	Sulfatase; Region: Sulfatase; cl19157
157239001035	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
157239001036	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
157239001037	active site
157239001038	HIGH motif; other site
157239001039	KMSKS motif; other site
157239001040	ribonuclease PH; Reviewed; Region: rph; PRK00173
157239001041	Ribonuclease PH; Region: RNase_PH_bact; cd11362
157239001042	hexamer interface [polypeptide binding]; other site
157239001043	active site
157239001044	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239001045	active site
157239001046	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
157239001047	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
157239001048	putative metal binding site [ion binding]; other site
157239001049	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
157239001050	HSP70 interaction site [polypeptide binding]; other site
157239001051	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
157239001052	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
157239001053	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
157239001054	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
157239001055	DNA binding residues [nucleotide binding]
157239001056	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
157239001057	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
157239001058	FAD binding domain; Region: FAD_binding_4; pfam01565
157239001059	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
157239001060	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
157239001061	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
157239001062	HAMP domain; Region: HAMP; pfam00672
157239001063	Histidine kinase; Region: HisKA_3; pfam07730
157239001064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
157239001065	ATP binding site [chemical binding]; other site
157239001066	Mg2+ binding site [ion binding]; other site
157239001067	G-X-G motif; other site
157239001068	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
157239001069	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
157239001070	homooctamer interface [polypeptide binding]; other site
157239001071	active site
157239001072	haemagglutination activity domain; Region: Haemagg_act; pfam05860
157239001073	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
157239001074	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
157239001075	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
157239001076	Surface antigen; Region: Bac_surface_Ag; pfam01103
157239001077	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
157239001078	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
157239001079	N-terminal plug; other site
157239001080	ligand-binding site [chemical binding]; other site
157239001081	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
157239001082	putative active site [active]
157239001083	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
157239001084	active site
157239001085	ATP binding site [chemical binding]; other site
157239001086	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
157239001087	active site
157239001088	dimerization interface [polypeptide binding]; other site
157239001089	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
157239001090	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
157239001091	Ligand binding site; other site
157239001092	metal-binding site
157239001093	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
157239001094	30S subunit binding site; other site
157239001095	NlpB/DapX lipoprotein; Region: Lipoprotein_18; cl19507
157239001096	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
157239001097	dimer interface [polypeptide binding]; other site
157239001098	active site
157239001099	catalytic residue [active]
157239001100	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
157239001101	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
157239001102	catalytic triad [active]
157239001103	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
157239001104	TonB system transport protein ExbD, group 2; Region: ExbD_2; TIGR02804
157239001105	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
157239001106	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
157239001107	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
157239001108	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
157239001109	dimer interface [polypeptide binding]; other site
157239001110	ssDNA binding site [nucleotide binding]; other site
157239001111	tetramer (dimer of dimers) interface [polypeptide binding]; other site
157239001112	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
157239001113	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
157239001114	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
157239001115	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
157239001116	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
157239001117	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
157239001118	Autotransporter beta-domain; Region: Autotransporter; pfam03797
157239001119	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
157239001120	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
157239001121	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
157239001122	Hemerythrin-like domain; Region: Hr-like; cd12108
157239001123	Fe binding site [ion binding]; other site
157239001124	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
157239001125	CPxP  motif; other site
157239001126	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
157239001127	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
157239001128	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
157239001129	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
157239001130	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
157239001131	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
157239001132	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
157239001133	Protein export membrane protein; Region: SecD_SecF; pfam02355
157239001134	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
157239001135	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
157239001136	catalytic residues [active]
157239001137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
157239001138	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
157239001139	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
157239001140	substrate binding pocket [chemical binding]; other site
157239001141	membrane-bound complex binding site; other site
157239001142	hinge residues; other site
157239001143	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
157239001144	N-acetyl-D-glucosamine binding site [chemical binding]; other site
157239001145	catalytic residue [active]
157239001146	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
157239001147	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
157239001148	ATP binding site [chemical binding]; other site
157239001149	Mg++ binding site [ion binding]; other site
157239001150	motif III; other site
157239001151	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239001152	nucleotide binding region [chemical binding]; other site
157239001153	ATP-binding site [chemical binding]; other site
157239001154	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
157239001155	putative RNA binding site [nucleotide binding]; other site
157239001156	Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785
157239001157	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
157239001158	binding surface
157239001159	TPR motif; other site
157239001160	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
157239001161	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
157239001162	RNase E interface [polypeptide binding]; other site
157239001163	trimer interface [polypeptide binding]; other site
157239001164	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
157239001165	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
157239001166	RNase E interface [polypeptide binding]; other site
157239001167	trimer interface [polypeptide binding]; other site
157239001168	active site
157239001169	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
157239001170	putative nucleic acid binding region [nucleotide binding]; other site
157239001171	G-X-X-G motif; other site
157239001172	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
157239001173	RNA binding site [nucleotide binding]; other site
157239001174	domain interface; other site
157239001175	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
157239001176	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
157239001177	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
157239001178	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
157239001179	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
157239001180	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
157239001181	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
157239001182	putative DNA binding site [nucleotide binding]; other site
157239001183	putative Zn2+ binding site [ion binding]; other site
157239001184	Predicted permeases [General function prediction only]; Region: RarD; COG2962
157239001185	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
157239001186	GMP synthase; Reviewed; Region: guaA; PRK00074
157239001187	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
157239001188	AMP/PPi binding site [chemical binding]; other site
157239001189	candidate oxyanion hole; other site
157239001190	catalytic triad [active]
157239001191	potential glutamine specificity residues [chemical binding]; other site
157239001192	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
157239001193	ATP Binding subdomain [chemical binding]; other site
157239001194	Ligand Binding sites [chemical binding]; other site
157239001195	Dimerization subdomain; other site
157239001196	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
157239001197	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
157239001198	active site
157239001199	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
157239001200	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
157239001201	HTH domain; Region: HTH_11; cl17392
157239001202	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
157239001203	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
157239001204	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
157239001205	putative uracil binding site [chemical binding]; other site
157239001206	putative active site [active]
157239001207	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
157239001208	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
157239001209	dimer interface [polypeptide binding]; other site
157239001210	phosphorylation site [posttranslational modification]
157239001211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
157239001212	ATP binding site [chemical binding]; other site
157239001213	Mg2+ binding site [ion binding]; other site
157239001214	G-X-G motif; other site
157239001215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
157239001216	active site
157239001217	phosphorylation site [posttranslational modification]
157239001218	intermolecular recognition site; other site
157239001219	dimerization interface [polypeptide binding]; other site
157239001220	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
157239001221	putative binding surface; other site
157239001222	active site
157239001223	Predicted membrane protein [Function unknown]; Region: COG3059
157239001224	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
157239001225	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
157239001226	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239001227	ATP binding site [chemical binding]; other site
157239001228	putative Mg++ binding site [ion binding]; other site
157239001229	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
157239001230	Abi-like protein; Region: Abi_2; cl01988
157239001231	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
157239001232	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
157239001233	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
157239001234	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
157239001235	HsdM N-terminal domain; Region: HsdM_N; pfam12161
157239001236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239001237	S-adenosylmethionine binding site [chemical binding]; other site
157239001238	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
157239001239	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
157239001240	active site
157239001241	Zn binding site [ion binding]; other site
157239001242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
157239001243	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
157239001244	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
157239001245	peptide binding site [polypeptide binding]; other site
157239001246	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
157239001247	dimerization interface [polypeptide binding]; other site
157239001248	active site
157239001249	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
157239001250	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
157239001251	active site
157239001252	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
157239001253	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
157239001254	active site
157239001255	dimer interface [polypeptide binding]; other site
157239001256	metal binding site [ion binding]; metal-binding site
157239001257	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
157239001258	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
157239001259	ADP binding site [chemical binding]; other site
157239001260	magnesium binding site [ion binding]; other site
157239001261	putative shikimate binding site; other site
157239001262	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
157239001263	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
157239001264	active site
157239001265	metal binding site [ion binding]; metal-binding site
157239001266	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
157239001267	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
157239001268	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
157239001269	RimM N-terminal domain; Region: RimM; pfam01782
157239001270	PRC-barrel domain; Region: PRC; pfam05239
157239001271	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
157239001272	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
157239001273	selenophosphate synthetase; Provisional; Region: PRK00943
157239001274	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
157239001275	dimerization interface [polypeptide binding]; other site
157239001276	putative ATP binding site [chemical binding]; other site
157239001277	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
157239001278	putative acyl-acceptor binding pocket; other site
157239001279	hypothetical protein; Provisional; Region: PRK10621
157239001280	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
157239001281	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
157239001282	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
157239001283	Tetramer interface [polypeptide binding]; other site
157239001284	active site
157239001285	FMN-binding site [chemical binding]; other site
157239001286	hypothetical protein; Provisional; Region: PRK11281
157239001287	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
157239001288	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
157239001289	Mechanosensitive ion channel; Region: MS_channel; pfam00924
157239001290	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
157239001291	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
157239001292	acyl-activating enzyme (AAE) consensus motif; other site
157239001293	putative AMP binding site [chemical binding]; other site
157239001294	putative active site [active]
157239001295	putative CoA binding site [chemical binding]; other site
157239001296	replication initiation regulator SeqA; Provisional; Region: PRK11187
157239001297	Putative lysophospholipase; Region: Hydrolase_4; cl19140
157239001298	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
157239001299	flavodoxin FldA; Validated; Region: PRK09267
157239001300	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
157239001301	metal binding site 2 [ion binding]; metal-binding site
157239001302	putative DNA binding helix; other site
157239001303	metal binding site 1 [ion binding]; metal-binding site
157239001304	dimer interface [polypeptide binding]; other site
157239001305	structural Zn2+ binding site [ion binding]; other site
157239001306	glutamate dehydrogenase; Provisional; Region: PRK09414
157239001307	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
157239001308	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
157239001309	NAD(P) binding site [chemical binding]; other site
157239001310	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
157239001311	sec-independent translocase; Provisional; Region: PRK01770
157239001312	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
157239001313	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
157239001314	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
157239001315	DNA binding residues [nucleotide binding]
157239001316	putative dimer interface [polypeptide binding]; other site
157239001317	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
157239001318	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
157239001319	substrate binding site [chemical binding]; other site
157239001320	catalytic Zn binding site [ion binding]; other site
157239001321	NAD binding site [chemical binding]; other site
157239001322	structural Zn binding site [ion binding]; other site
157239001323	dimer interface [polypeptide binding]; other site
157239001324	Predicted esterase [General function prediction only]; Region: COG0627
157239001325	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
157239001326	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
157239001327	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
157239001328	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
157239001329	nucleotide binding site [chemical binding]; other site
157239001330	formate transporter FocA; Region: formate_focA; TIGR04060
157239001331	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
157239001332	Pyruvate formate lyase 1; Region: PFL1; cd01678
157239001333	coenzyme A binding site [chemical binding]; other site
157239001334	active site
157239001335	catalytic residues [active]
157239001336	glycine loop; other site
157239001337	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
157239001338	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239001339	FeS/SAM binding site; other site
157239001340	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
157239001341	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
157239001342	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
157239001343	RNA binding surface [nucleotide binding]; other site
157239001344	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
157239001345	active site
157239001346	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
157239001347	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
157239001348	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
157239001349	Ligand Binding Site [chemical binding]; other site
157239001350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
157239001351	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
157239001352	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
157239001353	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
157239001354	FAD binding pocket [chemical binding]; other site
157239001355	FAD binding motif [chemical binding]; other site
157239001356	phosphate binding motif [ion binding]; other site
157239001357	beta-alpha-beta structure motif; other site
157239001358	NAD binding pocket [chemical binding]; other site
157239001359	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
157239001360	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
157239001361	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869
157239001362	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
157239001363	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
157239001364	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
157239001365	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
157239001366	lipoyl-biotinyl attachment site [posttranslational modification]; other site
157239001367	Pleckstrin homology-like domain; Region: PH-like; cl17171
157239001368	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
157239001369	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
157239001370	Uncharacterized lipoprotein; Region: Lipoprotein_16; cl19472
157239001371	glutathione reductase; Validated; Region: PRK06116
157239001372	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
157239001373	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
157239001374	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
157239001375	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
157239001376	hypothetical protein; Provisional; Region: PRK11193
157239001377	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
157239001378	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
157239001379	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
157239001380	dimer interface [polypeptide binding]; other site
157239001381	active site
157239001382	CoA binding pocket [chemical binding]; other site
157239001383	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
157239001384	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
157239001385	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
157239001386	NAD(P) binding site [chemical binding]; other site
157239001387	homotetramer interface [polypeptide binding]; other site
157239001388	homodimer interface [polypeptide binding]; other site
157239001389	active site
157239001390	acyl carrier protein; Provisional; Region: acpP; PRK00982
157239001391	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
157239001392	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
157239001393	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
157239001394	FtsH protease regulator HflK; Provisional; Region: PRK10930
157239001395	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
157239001396	High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404
157239001397	HflC protein; Region: hflC; TIGR01932
157239001398	High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405
157239001399	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
157239001400	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
157239001401	Kelch motif; Region: Kelch_1; pfam01344
157239001402	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
157239001403	DctM-like transporters; Region: DctM; pfam06808
157239001404	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
157239001405	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
157239001406	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
157239001407	putative active site cavity [active]
157239001408	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
157239001409	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
157239001410	nucleotide binding site [chemical binding]; other site
157239001411	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
157239001412	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
157239001413	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
157239001414	putative active site [active]
157239001415	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
157239001416	inhibitor site; inhibition site
157239001417	active site
157239001418	dimer interface [polypeptide binding]; other site
157239001419	catalytic residue [active]
157239001420	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
157239001421	active site
157239001422	trimer interface [polypeptide binding]; other site
157239001423	allosteric site; other site
157239001424	active site lid [active]
157239001425	hexamer (dimer of trimers) interface [polypeptide binding]; other site
157239001426	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
157239001427	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
157239001428	active site
157239001429	dimer interface [polypeptide binding]; other site
157239001430	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
157239001431	trimer interface [polypeptide binding]; other site
157239001432	eyelet of channel; other site
157239001433	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
157239001434	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
157239001435	RNA/DNA hybrid binding site [nucleotide binding]; other site
157239001436	active site
157239001437	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
157239001438	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
157239001439	active site
157239001440	catalytic site [active]
157239001441	substrate binding site [chemical binding]; other site
157239001442	GTP-binding protein Der; Reviewed; Region: PRK00093
157239001443	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
157239001444	G1 box; other site
157239001445	GTP/Mg2+ binding site [chemical binding]; other site
157239001446	Switch I region; other site
157239001447	G2 box; other site
157239001448	Switch II region; other site
157239001449	G3 box; other site
157239001450	G4 box; other site
157239001451	G5 box; other site
157239001452	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
157239001453	G1 box; other site
157239001454	GTP/Mg2+ binding site [chemical binding]; other site
157239001455	Switch I region; other site
157239001456	G2 box; other site
157239001457	G3 box; other site
157239001458	Switch II region; other site
157239001459	G4 box; other site
157239001460	G5 box; other site
157239001461	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
157239001462	putative arabinose transporter; Provisional; Region: PRK03545
157239001463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239001464	putative substrate translocation pore; other site
157239001465	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
157239001466	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
157239001467	trimer interface [polypeptide binding]; other site
157239001468	active site
157239001469	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
157239001470	ATP-binding site [chemical binding]; other site
157239001471	Sugar specificity; other site
157239001472	Pyrimidine base specificity; other site
157239001473	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
157239001474	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
157239001475	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
157239001476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239001477	dimer interface [polypeptide binding]; other site
157239001478	conserved gate region; other site
157239001479	putative PBP binding loops; other site
157239001480	ABC-ATPase subunit interface; other site
157239001481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239001482	dimer interface [polypeptide binding]; other site
157239001483	conserved gate region; other site
157239001484	putative PBP binding loops; other site
157239001485	ABC-ATPase subunit interface; other site
157239001486	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
157239001487	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
157239001488	Walker A/P-loop; other site
157239001489	ATP binding site [chemical binding]; other site
157239001490	Q-loop/lid; other site
157239001491	ABC transporter signature motif; other site
157239001492	Walker B; other site
157239001493	D-loop; other site
157239001494	H-loop/switch region; other site
157239001495	TOBE domain; Region: TOBE_2; pfam08402
157239001496	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
157239001497	Sulfate transporter family; Region: Sulfate_transp; cl19250
157239001498	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
157239001499	dimer interface [polypeptide binding]; other site
157239001500	substrate binding site [chemical binding]; other site
157239001501	metal binding sites [ion binding]; metal-binding site
157239001502	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
157239001503	peroxidase; Provisional; Region: PRK15000
157239001504	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
157239001505	dimer interface [polypeptide binding]; other site
157239001506	decamer (pentamer of dimers) interface [polypeptide binding]; other site
157239001507	catalytic triad [active]
157239001508	peroxidatic and resolving cysteines [active]
157239001509	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
157239001510	homodimer interface [polypeptide binding]; other site
157239001511	substrate-cofactor binding pocket; other site
157239001512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239001513	catalytic residue [active]
157239001514	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
157239001515	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
157239001516	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
157239001517	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
157239001518	Uncharacterized integral membrane protein [Function unknown]; Region: COG5413
157239001519	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
157239001520	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
157239001521	metal binding site [ion binding]; metal-binding site
157239001522	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
157239001523	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
157239001524	putative ATP binding site [chemical binding]; other site
157239001525	putative substrate interface [chemical binding]; other site
157239001526	murein transglycosylase A; Provisional; Region: mltA; PRK11162
157239001527	MltA specific insert domain; Region: MltA; smart00925
157239001528	3D domain; Region: 3D; pfam06725
157239001529	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
157239001530	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
157239001531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239001532	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
157239001533	putative RNA binding site [nucleotide binding]; other site
157239001534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239001535	S-adenosylmethionine binding site [chemical binding]; other site
157239001536	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
157239001537	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
157239001538	N-terminal plug; other site
157239001539	ligand-binding site [chemical binding]; other site
157239001540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
157239001541	Helix-turn-helix domain; Region: HTH_28; pfam13518
157239001542	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
157239001543	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
157239001544	C-terminal domain interface [polypeptide binding]; other site
157239001545	GSH binding site (G-site) [chemical binding]; other site
157239001546	dimer interface [polypeptide binding]; other site
157239001547	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
157239001548	dimer interface [polypeptide binding]; other site
157239001549	N-terminal domain interface [polypeptide binding]; other site
157239001550	substrate binding pocket (H-site) [chemical binding]; other site
157239001551	seryl-tRNA synthetase; Provisional; Region: PRK05431
157239001552	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
157239001553	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
157239001554	dimer interface [polypeptide binding]; other site
157239001555	active site
157239001556	motif 1; other site
157239001557	motif 2; other site
157239001558	motif 3; other site
157239001559	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
157239001560	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
157239001561	Uncharacterized conserved protein [Function unknown]; Region: COG2966
157239001562	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
157239001563	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
157239001564	Domain of unknown function DUF21; Region: DUF21; pfam01595
157239001565	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
157239001566	Transporter associated domain; Region: CorC_HlyC; smart01091
157239001567	signal recognition particle protein; Provisional; Region: PRK10867
157239001568	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
157239001569	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
157239001570	P loop; other site
157239001571	GTP binding site [chemical binding]; other site
157239001572	Signal peptide binding domain; Region: SRP_SPB; pfam02978
157239001573	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
157239001574	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
157239001575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239001576	ATP binding site [chemical binding]; other site
157239001577	putative Mg++ binding site [ion binding]; other site
157239001578	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
157239001579	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
157239001580	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
157239001581	Divergent AAA domain; Region: AAA_4; pfam04326
157239001582	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
157239001583	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
157239001584	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
157239001585	HsdM N-terminal domain; Region: HsdM_N; pfam12161
157239001586	Methyltransferase domain; Region: Methyltransf_26; pfam13659
157239001587	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
157239001588	heat shock protein 90; Provisional; Region: PRK05218
157239001589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
157239001590	ATP binding site [chemical binding]; other site
157239001591	Mg2+ binding site [ion binding]; other site
157239001592	G-X-G motif; other site
157239001593	Hsp90 protein; Region: HSP90; pfam00183
157239001594	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
157239001595	putative catalytic residues [active]
157239001596	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
157239001597	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
157239001598	metal binding site [ion binding]; metal-binding site
157239001599	dimer interface [polypeptide binding]; other site
157239001600	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
157239001601	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
157239001602	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
157239001603	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
157239001604	Walker A/P-loop; other site
157239001605	ATP binding site [chemical binding]; other site
157239001606	Q-loop/lid; other site
157239001607	ABC transporter signature motif; other site
157239001608	Walker B; other site
157239001609	D-loop; other site
157239001610	H-loop/switch region; other site
157239001611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239001612	dimer interface [polypeptide binding]; other site
157239001613	conserved gate region; other site
157239001614	putative PBP binding loops; other site
157239001615	ABC-ATPase subunit interface; other site
157239001616	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
157239001617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239001618	dimer interface [polypeptide binding]; other site
157239001619	conserved gate region; other site
157239001620	putative PBP binding loops; other site
157239001621	ABC-ATPase subunit interface; other site
157239001622	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
157239001623	Methyltransferase domain; Region: Methyltransf_31; pfam13847
157239001624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239001625	S-adenosylmethionine binding site [chemical binding]; other site
157239001626	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
157239001627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
157239001628	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
157239001629	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
157239001630	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
157239001631	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
157239001632	fructuronate transporter; Provisional; Region: PRK10034; cl15264
157239001633	Glycerate kinase family; Region: Gly_kinase; pfam02595
157239001634	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
157239001635	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
157239001636	catalytic residue [active]
157239001637	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
157239001638	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
157239001639	nucleotide binding site [chemical binding]; other site
157239001640	substrate binding site [chemical binding]; other site
157239001641	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
157239001642	dimer interface [polypeptide binding]; other site
157239001643	putative threonine allosteric regulatory site; other site
157239001644	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
157239001645	putative threonine allosteric regulatory site; other site
157239001646	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
157239001647	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
157239001648	homoserine kinase; Region: thrB; TIGR00191
157239001649	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
157239001650	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
157239001651	threonine synthase; Validated; Region: PRK09225
157239001652	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
157239001653	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
157239001654	catalytic residue [active]
157239001655	integrase; Provisional; Region: int; PHA02601
157239001656	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
157239001657	dimer interface [polypeptide binding]; other site
157239001658	active site
157239001659	catalytic residues [active]
157239001660	Int/Topo IB signature motif; other site
157239001661	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
157239001662	hypothetical protein; Provisional; Region: PRK10040
157239001663	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
157239001664	Predicted membrane protein [Function unknown]; Region: COG4709
157239001665	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
157239001666	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
157239001667	YcfA-like protein; Region: YcfA; cl00752
157239001668	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
157239001669	portal vertex protein; Provisional; Region: Q; PHA02536
157239001670	terminase ATPase subunit; Provisional; Region: P; PHA02535
157239001671	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
157239001672	capsid-scaffolding protein; Provisional; Region: O; PHA02529
157239001673	phage major capsid protein, P2 family; Region: major_capsid_P2; TIGR01551
157239001674	terminase endonuclease subunit; Provisional; Region: M; PHA02537
157239001675	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
157239001676	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
157239001677	Protein of unknown function (DUF2586); Region: DUF2586; pfam10758
157239001678	Protein of unknown function (DUF2597); Region: DUF2597; pfam10772
157239001679	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
157239001680	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
157239001681	catalytic residues [active]
157239001682	HemX; Region: HemX; cl19375
157239001683	Protein of unknown function (DUF2765); Region: DUF2765; pfam10963
157239001684	Phage-related tail protein [Function unknown]; Region: COG5283
157239001685	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
157239001686	Protein of unknown function (DUF2590); Region: DUF2590; pfam10761
157239001687	Baseplate J-like protein; Region: Baseplate_J; cl01294
157239001688	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
157239001689	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
157239001690	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
157239001691	Phage Tail Collar Domain; Region: Collar; pfam07484
157239001692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
157239001693	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
157239001694	active site
157239001695	catalytic residues [active]
157239001696	DNA binding site [nucleotide binding]
157239001697	Int/Topo IB signature motif; other site
157239001698	Putative helicase; Region: TraI_2; pfam07514
157239001699	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
157239001700	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239001701	active site
157239001702	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
157239001703	multiple promoter invertase; Provisional; Region: mpi; PRK13413
157239001704	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
157239001705	catalytic residues [active]
157239001706	catalytic nucleophile [active]
157239001707	Presynaptic Site I dimer interface [polypeptide binding]; other site
157239001708	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
157239001709	Synaptic Flat tetramer interface [polypeptide binding]; other site
157239001710	Synaptic Site I dimer interface [polypeptide binding]; other site
157239001711	DNA binding site [nucleotide binding]
157239001712	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
157239001713	DNA-binding interface [nucleotide binding]; DNA binding site
157239001714	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
157239001715	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
157239001716	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
157239001717	phosphoribosylaminoimidazole carboxylase; Region: PLN02948
157239001718	Ssu72-like protein; Region: Ssu72; cl02161
157239001719	integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757
157239001720	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
157239001721	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
157239001722	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
157239001723	catalytic residue [active]
157239001724	beta-lactamase TEM; Provisional; Region: PRK15442
157239001725	multiple promoter invertase; Provisional; Region: mpi; PRK13413
157239001726	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
157239001727	catalytic residues [active]
157239001728	catalytic nucleophile [active]
157239001729	Presynaptic Site I dimer interface [polypeptide binding]; other site
157239001730	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
157239001731	Synaptic Flat tetramer interface [polypeptide binding]; other site
157239001732	Synaptic Site I dimer interface [polypeptide binding]; other site
157239001733	DNA binding site [nucleotide binding]
157239001734	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
157239001735	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
157239001736	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
157239001737	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
157239001738	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
157239001739	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
157239001740	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
157239001741	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
157239001742	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
157239001743	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
157239001744	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
157239001745	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
157239001746	Protein of unknown function (DUF2976); Region: DUF2976; pfam11190
157239001747	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
157239001748	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
157239001749	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
157239001750	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
157239001751	AAA-like domain; Region: AAA_10; pfam12846
157239001752	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
157239001753	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
157239001754	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
157239001755	catalytic residue [active]
157239001756	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
157239001757	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
157239001758	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
157239001759	TraX protein; Region: TraX; pfam05857
157239001760	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
157239001761	MPN+ (JAMM) motif; other site
157239001762	Zinc-binding site [ion binding]; other site
157239001763	Protein of unknown function (DUF328); Region: DUF328; cl01143
157239001764	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
157239001765	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
157239001766	DNA topoisomerase III; Provisional; Region: PRK07726
157239001767	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
157239001768	active site
157239001769	putative interdomain interaction site [polypeptide binding]; other site
157239001770	putative metal-binding site [ion binding]; other site
157239001771	putative nucleotide binding site [chemical binding]; other site
157239001772	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
157239001773	domain I; other site
157239001774	DNA binding groove [nucleotide binding]
157239001775	phosphate binding site [ion binding]; other site
157239001776	domain II; other site
157239001777	domain III; other site
157239001778	nucleotide binding site [chemical binding]; other site
157239001779	catalytic site [active]
157239001780	domain IV; other site
157239001781	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
157239001782	YedD-like protein; Region: YedD; cl08117
157239001783	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
157239001784	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
157239001785	dimer interface [polypeptide binding]; other site
157239001786	ssDNA binding site [nucleotide binding]; other site
157239001787	tetramer (dimer of dimers) interface [polypeptide binding]; other site
157239001788	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
157239001789	integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761
157239001790	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
157239001791	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
157239001792	replicative DNA helicase; Region: DnaB; TIGR00665
157239001793	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
157239001794	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
157239001795	Walker A motif; other site
157239001796	ATP binding site [chemical binding]; other site
157239001797	Walker B motif; other site
157239001798	DNA binding loops [nucleotide binding]
157239001799	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
157239001800	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
157239001801	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
157239001802	P-loop; other site
157239001803	Magnesium ion binding site [ion binding]; other site
157239001804	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
157239001805	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
157239001806	homodimer interface [polypeptide binding]; other site
157239001807	substrate-cofactor binding pocket; other site
157239001808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239001809	catalytic residue [active]
157239001810	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
157239001811	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
157239001812	putative ligand binding site [chemical binding]; other site
157239001813	putative NAD binding site [chemical binding]; other site
157239001814	catalytic site [active]
157239001815	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
157239001816	catalytic residues [active]
157239001817	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
157239001818	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
157239001819	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
157239001820	active site
157239001821	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
157239001822	substrate binding site [chemical binding]; other site
157239001823	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
157239001824	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
157239001825	active site
157239001826	HIGH motif; other site
157239001827	KMSKS motif; other site
157239001828	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
157239001829	tRNA binding surface [nucleotide binding]; other site
157239001830	anticodon binding site; other site
157239001831	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
157239001832	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
157239001833	active site
157239001834	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
157239001835	catalytic triad [active]
157239001836	dimer interface [polypeptide binding]; other site
157239001837	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
157239001838	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
157239001839	metal binding site [ion binding]; metal-binding site
157239001840	dimer interface [polypeptide binding]; other site
157239001841	hypothetical protein; Provisional; Region: PRK10519
157239001842	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
157239001843	Nucleoside recognition; Region: Gate; pfam07670
157239001844	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
157239001845	ATP cone domain; Region: ATP-cone; pfam03477
157239001846	Class III ribonucleotide reductase; Region: RNR_III; cd01675
157239001847	effector binding site; other site
157239001848	active site
157239001849	Zn binding site [ion binding]; other site
157239001850	glycine loop; other site
157239001851	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
157239001852	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
157239001853	active site
157239001854	NTP binding site [chemical binding]; other site
157239001855	metal binding triad [ion binding]; metal-binding site
157239001856	antibiotic binding site [chemical binding]; other site
157239001857	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
157239001858	dimer interface [polypeptide binding]; other site
157239001859	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
157239001860	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
157239001861	DNA repair protein RecN; Region: recN; TIGR00634
157239001862	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
157239001863	Walker A/P-loop; other site
157239001864	ATP binding site [chemical binding]; other site
157239001865	Q-loop/lid; other site
157239001866	Plant nuclear matrix protein 1 (NMP1); Region: Plant_NMP1; pfam06694
157239001867	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
157239001868	ABC transporter signature motif; other site
157239001869	Walker B; other site
157239001870	D-loop; other site
157239001871	H-loop/switch region; other site
157239001872	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
157239001873	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
157239001874	metal binding triad; other site
157239001875	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
157239001876	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
157239001877	metal binding triad; other site
157239001878	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627
157239001879	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
157239001880	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
157239001881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
157239001882	ATP binding site [chemical binding]; other site
157239001883	Mg2+ binding site [ion binding]; other site
157239001884	G-X-G motif; other site
157239001885	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
157239001886	ATP binding site [chemical binding]; other site
157239001887	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
157239001888	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
157239001889	active site
157239001890	metal binding site [ion binding]; metal-binding site
157239001891	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
157239001892	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
157239001893	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
157239001894	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
157239001895	tRNA threonylcarbamoyl adenosine modification protein YjeE; Region: T6A_YjeE; TIGR00150
157239001896	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
157239001897	catalytic center binding site [active]
157239001898	ATP binding site [chemical binding]; other site
157239001899	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
157239001900	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
157239001901	active site
157239001902	NTP binding site [chemical binding]; other site
157239001903	metal binding triad [ion binding]; metal-binding site
157239001904	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
157239001905	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
157239001906	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
157239001907	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
157239001908	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
157239001909	ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360
157239001910	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
157239001911	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
157239001912	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
157239001913	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239001914	Walker A/P-loop; other site
157239001915	ATP binding site [chemical binding]; other site
157239001916	Q-loop/lid; other site
157239001917	ABC transporter signature motif; other site
157239001918	Walker B; other site
157239001919	D-loop; other site
157239001920	H-loop/switch region; other site
157239001921	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
157239001922	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
157239001923	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
157239001924	Ligand binding site; other site
157239001925	oligomer interface; other site
157239001926	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
157239001927	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
157239001928	GIY-YIG motif/motif A; other site
157239001929	active site
157239001930	catalytic site [active]
157239001931	putative DNA binding site [nucleotide binding]; other site
157239001932	metal binding site [ion binding]; metal-binding site
157239001933	UvrB/uvrC motif; Region: UVR; pfam02151
157239001934	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
157239001935	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
157239001936	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
157239001937	mannonate dehydratase; Provisional; Region: PRK03906
157239001938	mannonate dehydratase; Region: uxuA; TIGR00695
157239001939	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
157239001940	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
157239001941	DNA-binding site [nucleotide binding]; DNA binding site
157239001942	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
157239001943	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
157239001944	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
157239001945	NAD(P) binding site [chemical binding]; other site
157239001946	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
157239001947	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
157239001948	DctM-like transporters; Region: DctM; pfam06808
157239001949	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
157239001950	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
157239001951	substrate binding site [chemical binding]; other site
157239001952	ATP binding site [chemical binding]; other site
157239001953	D-mannonate oxidoreductase; Provisional; Region: PRK08277
157239001954	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
157239001955	putative NAD(P) binding site [chemical binding]; other site
157239001956	active site
157239001957	Entner-Doudoroff aldolase; Region: eda; TIGR01182
157239001958	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
157239001959	active site
157239001960	intersubunit interface [polypeptide binding]; other site
157239001961	catalytic residue [active]
157239001962	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
157239001963	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
157239001964	PhnA protein; Region: PhnA; pfam03831
157239001965	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398
157239001966	YccA-like proteins; Region: YccA_like; cd10433
157239001967	Predicted membrane protein [Function unknown]; Region: COG3768
157239001968	TIGR01620 family protein; Region: hyp_HI0043
157239001969	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
157239001970	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
157239001971	active site
157239001972	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
157239001973	putative catalytic site [active]
157239001974	putative phosphate binding site [ion binding]; other site
157239001975	active site
157239001976	metal binding site A [ion binding]; metal-binding site
157239001977	DNA binding site [nucleotide binding]
157239001978	putative AP binding site [nucleotide binding]; other site
157239001979	putative metal binding site B [ion binding]; other site
157239001980	TIGR01619 family protein; Region: hyp_HI0040
157239001981	Family of unknown function (DUF695); Region: DUF695; pfam05117
157239001982	Regulator of ribonuclease activity B; Region: RraB; pfam06877
157239001983	rod shape-determining protein MreD; Region: MreD; cl01087
157239001984	rod shape-determining protein MreC; Region: mreC; TIGR00219
157239001985	rod shape-determining protein MreB; Provisional; Region: PRK13927
157239001986	MreB and similar proteins; Region: MreB_like; cd10225
157239001987	nucleotide binding site [chemical binding]; other site
157239001988	Mg binding site [ion binding]; other site
157239001989	putative protofilament interaction site [polypeptide binding]; other site
157239001990	RodZ interaction site [polypeptide binding]; other site
157239001991	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
157239001992	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
157239001993	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
157239001994	putative transporter; Validated; Region: PRK03818
157239001995	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
157239001996	TrkA-C domain; Region: TrkA_C; pfam02080
157239001997	TrkA-C domain; Region: TrkA_C; pfam02080
157239001998	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
157239001999	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
157239002000	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
157239002001	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
157239002002	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
157239002003	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
157239002004	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
157239002005	rare lipoprotein A; Region: rlpA; TIGR00413
157239002006	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
157239002007	Sporulation related domain; Region: SPOR; pfam05036
157239002008	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
157239002009	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
157239002010	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
157239002011	hypothetical protein; Provisional; Region: PRK04998
157239002012	lipoate-protein ligase B; Provisional; Region: PRK14342
157239002013	lipoyl synthase; Provisional; Region: PRK05481
157239002014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239002015	FeS/SAM binding site; other site
157239002016	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
157239002017	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
157239002018	putative active site [active]
157239002019	(T/H)XGH motif; other site
157239002020	citrate lyase subunit gamma; Provisional; Region: PRK13253
157239002021	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
157239002022	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
157239002023	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
157239002024	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
157239002025	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
157239002026	Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939
157239002027	anion transporter; Region: dass; TIGR00785
157239002028	transmembrane helices; other site
157239002029	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
157239002030	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
157239002031	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239002032	FeS/SAM binding site; other site
157239002033	TRAM domain; Region: TRAM; pfam01938
157239002034	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
157239002035	ligand binding site [chemical binding]; other site
157239002036	active site
157239002037	UGI interface [polypeptide binding]; other site
157239002038	catalytic site [active]
157239002039	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
157239002040	GTP-binding protein LepA; Provisional; Region: PRK05433
157239002041	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
157239002042	G1 box; other site
157239002043	putative GEF interaction site [polypeptide binding]; other site
157239002044	GTP/Mg2+ binding site [chemical binding]; other site
157239002045	Switch I region; other site
157239002046	G2 box; other site
157239002047	G3 box; other site
157239002048	Switch II region; other site
157239002049	G4 box; other site
157239002050	G5 box; other site
157239002051	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
157239002052	Elongation Factor G, domain II; Region: EFG_II; pfam14492
157239002053	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
157239002054	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
157239002055	signal peptidase I; Provisional; Region: PRK10861
157239002056	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
157239002057	Catalytic site [active]
157239002058	ribonuclease III; Reviewed; Region: rnc; PRK00102
157239002059	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
157239002060	dimerization interface [polypeptide binding]; other site
157239002061	active site
157239002062	metal binding site [ion binding]; metal-binding site
157239002063	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
157239002064	dsRNA binding site [nucleotide binding]; other site
157239002065	GTPase Era; Reviewed; Region: era; PRK00089
157239002066	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
157239002067	G1 box; other site
157239002068	GTP/Mg2+ binding site [chemical binding]; other site
157239002069	Switch I region; other site
157239002070	G2 box; other site
157239002071	Switch II region; other site
157239002072	G3 box; other site
157239002073	G4 box; other site
157239002074	G5 box; other site
157239002075	KH domain; Region: KH_2; pfam07650
157239002076	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
157239002077	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
157239002078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239002079	S-adenosylmethionine binding site [chemical binding]; other site
157239002080	DNA polymerase III, psi subunit; Region: DNA_III_psi; TIGR00664
157239002081	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
157239002082	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
157239002083	Coenzyme A binding pocket [chemical binding]; other site
157239002084	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
157239002085	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
157239002086	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
157239002087	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
157239002088	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
157239002089	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
157239002090	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
157239002091	[4Fe-4S] binding site [ion binding]; other site
157239002092	molybdopterin cofactor binding site; other site
157239002093	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
157239002094	molybdopterin cofactor binding site; other site
157239002095	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
157239002096	metal-binding heat shock protein; Provisional; Region: PRK00016
157239002097	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
157239002098	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
157239002099	active site
157239002100	motif I; other site
157239002101	motif II; other site
157239002102	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
157239002103	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
157239002104	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
157239002105	acyl-activating enzyme (AAE) consensus motif; other site
157239002106	putative AMP binding site [chemical binding]; other site
157239002107	putative active site [active]
157239002108	putative CoA binding site [chemical binding]; other site
157239002109	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
157239002110	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
157239002111	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
157239002112	Guanylate kinase; Region: Guanylate_kin; pfam00625
157239002113	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
157239002114	catalytic site [active]
157239002115	G-X2-G-X-G-K; other site
157239002116	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
157239002117	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
157239002118	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
157239002119	Zn2+ binding site [ion binding]; other site
157239002120	Mg2+ binding site [ion binding]; other site
157239002121	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
157239002122	synthetase active site [active]
157239002123	NTP binding site [chemical binding]; other site
157239002124	metal binding site [ion binding]; metal-binding site
157239002125	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
157239002126	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
157239002127	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
157239002128	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
157239002129	generic binding surface II; other site
157239002130	ssDNA binding site; other site
157239002131	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239002132	ATP binding site [chemical binding]; other site
157239002133	putative Mg++ binding site [ion binding]; other site
157239002134	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239002135	nucleotide binding region [chemical binding]; other site
157239002136	ATP-binding site [chemical binding]; other site
157239002137	glutamate racemase; Provisional; Region: PRK00865
157239002138	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
157239002139	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
157239002140	active site
157239002141	substrate binding site [chemical binding]; other site
157239002142	FMN binding site [chemical binding]; other site
157239002143	putative catalytic residues [active]
157239002144	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
157239002145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
157239002146	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
157239002147	putative dimerization interface [polypeptide binding]; other site
157239002148	4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346
157239002149	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
157239002150	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
157239002151	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
157239002152	G1 box; other site
157239002153	putative GEF interaction site [polypeptide binding]; other site
157239002154	GTP/Mg2+ binding site [chemical binding]; other site
157239002155	Switch I region; other site
157239002156	G2 box; other site
157239002157	G3 box; other site
157239002158	Switch II region; other site
157239002159	G4 box; other site
157239002160	G5 box; other site
157239002161	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
157239002162	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
157239002163	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
157239002164	NAD binding site [chemical binding]; other site
157239002165	homotetramer interface [polypeptide binding]; other site
157239002166	homodimer interface [polypeptide binding]; other site
157239002167	substrate binding site [chemical binding]; other site
157239002168	active site
157239002169	exoribonuclease II; Provisional; Region: PRK05054
157239002170	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
157239002171	RNB domain; Region: RNB; pfam00773
157239002172	S1 RNA binding domain; Region: S1; pfam00575
157239002173	RNA binding site [nucleotide binding]; other site
157239002174	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
157239002175	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
157239002176	HiaBD2_N domain of Trimeric autotransporter adhesin (GIN); Region: HiaBD2; pfam15403
157239002177	Tryptophan-ring motif of head of Trimeric autotransporter adhesin; Region: TAA-Trp-ring; pfam15401
157239002178	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
157239002179	HiaBD2_N domain of Trimeric autotransporter adhesin (GIN); Region: HiaBD2; pfam15403
157239002180	Tryptophan-ring motif of head of Trimeric autotransporter adhesin; Region: TAA-Trp-ring; pfam15401
157239002181	YadA-like C-terminal region; Region: YadA_anchor; pfam03895
157239002182	sensor histidine kinase inhibitor, KipI family; Region: TIGR00370
157239002183	biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724
157239002184	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
157239002185	putative active site [active]
157239002186	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
157239002187	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
157239002188	ANP binding site [chemical binding]; other site
157239002189	Substrate Binding Site II [chemical binding]; other site
157239002190	Substrate Binding Site I [chemical binding]; other site
157239002191	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
157239002192	ATP binding site [chemical binding]; other site
157239002193	active site
157239002194	phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959
157239002195	substrate binding site [chemical binding]; other site
157239002196	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
157239002197	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
157239002198	Transglycosylase; Region: Transgly; pfam00912
157239002199	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
157239002200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112
157239002201	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
157239002202	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
157239002203	active site
157239002204	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
157239002205	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
157239002206	metal binding triad; other site
157239002207	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
157239002208	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
157239002209	Zn2+ binding site [ion binding]; other site
157239002210	Mg2+ binding site [ion binding]; other site
157239002211	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
157239002212	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
157239002213	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
157239002214	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
157239002215	Mg++ binding site [ion binding]; other site
157239002216	putative catalytic motif [active]
157239002217	substrate binding site [chemical binding]; other site
157239002218	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
157239002219	catalytic site [active]
157239002220	putative active site [active]
157239002221	putative substrate binding site [chemical binding]; other site
157239002222	dimer interface [polypeptide binding]; other site
157239002223	GTPase RsgA; Reviewed; Region: PRK12288
157239002224	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
157239002225	RNA binding site [nucleotide binding]; other site
157239002226	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
157239002227	GTPase/Zn-binding domain interface [polypeptide binding]; other site
157239002228	GTP/Mg2+ binding site [chemical binding]; other site
157239002229	G4 box; other site
157239002230	G5 box; other site
157239002231	G1 box; other site
157239002232	Switch I region; other site
157239002233	G2 box; other site
157239002234	G3 box; other site
157239002235	Switch II region; other site
157239002236	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
157239002237	dimerization domain swap beta strand [polypeptide binding]; other site
157239002238	regulatory protein interface [polypeptide binding]; other site
157239002239	active site
157239002240	regulatory phosphorylation site [posttranslational modification]; other site
157239002241	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
157239002242	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
157239002243	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
157239002244	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
157239002245	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
157239002246	HPr interaction site; other site
157239002247	glycerol kinase (GK) interaction site [polypeptide binding]; other site
157239002248	active site
157239002249	phosphorylation site [posttranslational modification]
157239002250	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
157239002251	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
157239002252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
157239002253	active site
157239002254	phosphorylation site [posttranslational modification]
157239002255	intermolecular recognition site; other site
157239002256	dimerization interface [polypeptide binding]; other site
157239002257	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
157239002258	DNA binding site [nucleotide binding]
157239002259	sensor protein QseC; Provisional; Region: PRK10337
157239002260	HAMP domain; Region: HAMP; pfam00672
157239002261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
157239002262	dimer interface [polypeptide binding]; other site
157239002263	phosphorylation site [posttranslational modification]
157239002264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
157239002265	ATP binding site [chemical binding]; other site
157239002266	Mg2+ binding site [ion binding]; other site
157239002267	G-X-G motif; other site
157239002268	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
157239002269	multifunctional aminopeptidase A; Provisional; Region: PRK00913
157239002270	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
157239002271	interface (dimer of trimers) [polypeptide binding]; other site
157239002272	Substrate-binding/catalytic site; other site
157239002273	Zn-binding sites [ion binding]; other site
157239002274	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074
157239002275	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
157239002276	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
157239002277	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
157239002278	THF binding site; other site
157239002279	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
157239002280	substrate binding site [chemical binding]; other site
157239002281	THF binding site; other site
157239002282	zinc-binding site [ion binding]; other site
157239002283	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
157239002284	putative active site [active]
157239002285	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
157239002286	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
157239002287	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
157239002288	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
157239002289	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
157239002290	putative ADP-binding pocket [chemical binding]; other site
157239002291	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
157239002292	colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017
157239002293	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
157239002294	active site
157239002295	GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195
157239002296	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
157239002297	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
157239002298	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
157239002299	molybdenum-pterin binding domain; Region: Mop; TIGR00638
157239002300	TOBE domain; Region: TOBE; pfam03459
157239002301	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
157239002302	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
157239002303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239002304	dimer interface [polypeptide binding]; other site
157239002305	conserved gate region; other site
157239002306	putative PBP binding loops; other site
157239002307	ABC-ATPase subunit interface; other site
157239002308	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
157239002309	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239002310	Walker A/P-loop; other site
157239002311	ATP binding site [chemical binding]; other site
157239002312	Q-loop/lid; other site
157239002313	ABC transporter signature motif; other site
157239002314	Walker B; other site
157239002315	D-loop; other site
157239002316	H-loop/switch region; other site
157239002317	TOBE domain; Region: TOBE; cl01440
157239002318	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
157239002319	Na2 binding site [ion binding]; other site
157239002320	putative substrate binding site 1 [chemical binding]; other site
157239002321	Na binding site 1 [ion binding]; other site
157239002322	putative substrate binding site 2 [chemical binding]; other site
157239002323	endonuclease III; Provisional; Region: PRK10702
157239002324	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
157239002325	minor groove reading motif; other site
157239002326	helix-hairpin-helix signature motif; other site
157239002327	substrate binding pocket [chemical binding]; other site
157239002328	active site
157239002329	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
157239002330	electron transport complex RsxE subunit; Provisional; Region: PRK12405
157239002331	electron transport complex protein RnfG; Validated; Region: PRK01908
157239002332	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
157239002333	electron transport complex protein RnfC; Provisional; Region: PRK05035
157239002334	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
157239002335	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
157239002336	SLBB domain; Region: SLBB; pfam10531
157239002337	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
157239002338	electron transport complex protein RnfB; Provisional; Region: PRK05113
157239002339	Putative Fe-S cluster; Region: FeS; pfam04060
157239002340	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
157239002341	electron transport complex protein RsxA; Provisional; Region: PRK05151
157239002342	putative inner membrane peptidase; Provisional; Region: PRK11778
157239002343	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
157239002344	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
157239002345	tandem repeat interface [polypeptide binding]; other site
157239002346	oligomer interface [polypeptide binding]; other site
157239002347	active site residues [active]
157239002348	hypothetical protein; Provisional; Region: PRK01904
157239002349	TIGR01666 family membrane protein; Region: YCCS
157239002350	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
157239002351	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
157239002352	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
157239002353	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
157239002354	active site
157239002355	motif I; other site
157239002356	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
157239002357	motif II; other site
157239002358	KpsF/GutQ family protein; Region: kpsF; TIGR00393
157239002359	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
157239002360	putative active site [active]
157239002361	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
157239002362	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
157239002363	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
157239002364	Hemerythrin-like domain; Region: Hr-like; cd12108
157239002365	Fe binding site [ion binding]; other site
157239002366	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
157239002367	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239002368	FeS/SAM binding site; other site
157239002369	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
157239002370	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
157239002371	trimer interface [polypeptide binding]; other site
157239002372	dimer interface [polypeptide binding]; other site
157239002373	putative active site [active]
157239002374	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
157239002375	MoaE interaction surface [polypeptide binding]; other site
157239002376	MoeB interaction surface [polypeptide binding]; other site
157239002377	thiocarboxylated glycine; other site
157239002378	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
157239002379	MoaE homodimer interface [polypeptide binding]; other site
157239002380	MoaD interaction [polypeptide binding]; other site
157239002381	active site residues [active]
157239002382	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
157239002383	mce related protein; Region: MCE; pfam02470
157239002384	mce related protein; Region: MCE; pfam02470
157239002385	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
157239002386	mce related protein; Region: MCE; pfam02470
157239002387	mce related protein; Region: MCE; pfam02470
157239002388	mce related protein; Region: MCE; pfam02470
157239002389	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
157239002390	Lysine biosynthesis protein LysW; Region: LysW; cl11748
157239002391	Zn binding site [ion binding]; other site
157239002392	ArgX binding interface [polypeptide binding]; other site
157239002393	Paraquat-inducible protein A; Region: PqiA; pfam04403
157239002394	zinc-ribbons; Region: zinc-ribbons_6; pfam07191
157239002395	Paraquat-inducible protein A; Region: PqiA; pfam04403
157239002396	ProP expression regulator; Provisional; Region: PRK04950
157239002397	carboxy-terminal protease; Provisional; Region: PRK11186
157239002398	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
157239002399	protein binding site [polypeptide binding]; other site
157239002400	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
157239002401	Catalytic dyad [active]
157239002402	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
157239002403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
157239002404	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
157239002405	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
157239002406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
157239002407	Peptidase M15; Region: Peptidase_M15_3; cl01194
157239002408	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
157239002409	active site
157239002410	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
157239002411	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
157239002412	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
157239002413	TPP-binding site [chemical binding]; other site
157239002414	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
157239002415	PYR/PP interface [polypeptide binding]; other site
157239002416	dimer interface [polypeptide binding]; other site
157239002417	TPP binding site [chemical binding]; other site
157239002418	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
157239002419	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
157239002420	E3 interaction surface; other site
157239002421	lipoyl attachment site [posttranslational modification]; other site
157239002422	e3 binding domain; Region: E3_binding; pfam02817
157239002423	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
157239002424	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
157239002425	dimer interface [polypeptide binding]; other site
157239002426	putative radical transfer pathway; other site
157239002427	diiron center [ion binding]; other site
157239002428	tyrosyl radical; other site
157239002429	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
157239002430	ATP cone domain; Region: ATP-cone; pfam03477
157239002431	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
157239002432	outer membrane lipoprotein; Provisional; Region: PRK11023
157239002433	BON domain; Region: BON; pfam04972
157239002434	BON domain; Region: BON; pfam04972
157239002435	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
157239002436	dimer interface [polypeptide binding]; other site
157239002437	active site
157239002438	TIGR00252 family protein; Region: TIGR00252
157239002439	LppC putative lipoprotein; Region: LppC; pfam04348
157239002440	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
157239002441	putative ligand binding site [chemical binding]; other site
157239002442	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
157239002443	putative SAM binding site [chemical binding]; other site
157239002444	putative homodimer interface [polypeptide binding]; other site
157239002445	Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356
157239002446	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
157239002447	NlpC/P60 family; Region: NLPC_P60; pfam00877
157239002448	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
157239002449	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
157239002450	D-lactate dehydrogenase; Provisional; Region: PRK11183
157239002451	FAD binding domain; Region: FAD_binding_4; cl19922
157239002452	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
157239002453	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
157239002454	predicted active site [active]
157239002455	catalytic triad [active]
157239002456	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
157239002457	active site
157239002458	multimer interface [polypeptide binding]; other site
157239002459	cytidylate kinase; Provisional; Region: cmk; PRK00023
157239002460	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
157239002461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239002462	Walker A/P-loop; other site
157239002463	ATP binding site [chemical binding]; other site
157239002464	Q-loop/lid; other site
157239002465	CMP-binding site; other site
157239002466	The sites determining sugar specificity; other site
157239002467	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
157239002468	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
157239002469	RNA binding site [nucleotide binding]; other site
157239002470	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
157239002471	RNA binding site [nucleotide binding]; other site
157239002472	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
157239002473	RNA binding site [nucleotide binding]; other site
157239002474	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
157239002475	RNA binding site [nucleotide binding]; other site
157239002476	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
157239002477	RNA binding site [nucleotide binding]; other site
157239002478	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
157239002479	RNA binding site [nucleotide binding]; other site
157239002480	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
157239002481	dimer interface [polypeptide binding]; other site
157239002482	DNA binding site [nucleotide binding]
157239002483	Predicted membrane protein [Function unknown]; Region: COG3771
157239002484	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
157239002485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
157239002486	binding surface
157239002487	TPR motif; other site
157239002488	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
157239002489	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
157239002490	active site
157239002491	dimer interface [polypeptide binding]; other site
157239002492	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
157239002493	putative rRNA binding site [nucleotide binding]; other site
157239002494	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
157239002495	DNA replication initiation factor; Validated; Region: PRK06893
157239002496	uracil-xanthine permease; Region: ncs2; TIGR00801
157239002497	Sulfate transporter family; Region: Sulfate_transp; cl19250
157239002498	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239002499	active site
157239002500	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
157239002501	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239002502	Walker A motif; other site
157239002503	ATP binding site [chemical binding]; other site
157239002504	Walker B motif; other site
157239002505	arginine finger; other site
157239002506	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
157239002507	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
157239002508	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239002509	active site
157239002510	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
157239002511	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
157239002512	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
157239002513	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
157239002514	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
157239002515	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
157239002516	E3 interaction surface; other site
157239002517	lipoyl attachment site [posttranslational modification]; other site
157239002518	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
157239002519	E3 interaction surface; other site
157239002520	lipoyl attachment site [posttranslational modification]; other site
157239002521	e3 binding domain; Region: E3_binding; pfam02817
157239002522	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
157239002523	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
157239002524	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
157239002525	dimer interface [polypeptide binding]; other site
157239002526	TPP-binding site [chemical binding]; other site
157239002527	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
157239002528	active site
157239002529	dimer interfaces [polypeptide binding]; other site
157239002530	catalytic residues [active]
157239002531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
157239002532	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
157239002533	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
157239002534	nucleotide binding site [chemical binding]; other site
157239002535	chaperone protein DnaJ; Provisional; Region: PRK10767
157239002536	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
157239002537	HSP70 interaction site [polypeptide binding]; other site
157239002538	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
157239002539	substrate binding site [polypeptide binding]; other site
157239002540	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
157239002541	Zn binding sites [ion binding]; other site
157239002542	dimer interface [polypeptide binding]; other site
157239002543	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
157239002544	putative catalytic cysteine [active]
157239002545	Predicted membrane protein [Function unknown]; Region: COG2860
157239002546	UPF0126 domain; Region: UPF0126; pfam03458
157239002547	UPF0126 domain; Region: UPF0126; pfam03458
157239002548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239002549	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
157239002550	putative substrate translocation pore; other site
157239002551	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
157239002552	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
157239002553	RNA binding surface [nucleotide binding]; other site
157239002554	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
157239002555	active site
157239002556	uracil binding [chemical binding]; other site
157239002557	Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955
157239002558	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
157239002559	Malic enzyme, N-terminal domain; Region: malic; pfam00390
157239002560	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
157239002561	putative NAD(P) binding site [chemical binding]; other site
157239002562	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
157239002563	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
157239002564	Sulfatase; Region: Sulfatase; pfam00884
157239002565	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
157239002566	excinuclease ABC subunit B; Provisional; Region: PRK05298
157239002567	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239002568	ATP-binding site [chemical binding]; other site
157239002569	ATP binding site [chemical binding]; other site
157239002570	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
157239002571	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239002572	nucleotide binding region [chemical binding]; other site
157239002573	ATP-binding site [chemical binding]; other site
157239002574	Ultra-violet resistance protein B; Region: UvrB; pfam12344
157239002575	UvrB/uvrC motif; Region: UVR; pfam02151
157239002576	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
157239002577	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
157239002578	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
157239002579	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239002580	non-specific DNA binding site [nucleotide binding]; other site
157239002581	salt bridge; other site
157239002582	sequence-specific DNA binding site [nucleotide binding]; other site
157239002583	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
157239002584	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
157239002585	ABC transporter; Region: ABC_tran_2; pfam12848
157239002586	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
157239002587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094
157239002588	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
157239002589	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
157239002590	Helicase; Region: Helicase_RecD; pfam05127
157239002591	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
157239002592	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
157239002593	transcription-repair coupling factor; Provisional; Region: PRK10689
157239002594	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
157239002595	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
157239002596	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239002597	ATP binding site [chemical binding]; other site
157239002598	putative Mg++ binding site [ion binding]; other site
157239002599	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239002600	nucleotide binding region [chemical binding]; other site
157239002601	ATP-binding site [chemical binding]; other site
157239002602	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
157239002603	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
157239002604	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
157239002605	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
157239002606	protein binding site [polypeptide binding]; other site
157239002607	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
157239002608	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
157239002609	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
157239002610	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
157239002611	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
157239002612	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
157239002613	putative active site [active]
157239002614	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
157239002615	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
157239002616	DNA gyrase subunit A; Validated; Region: PRK05560
157239002617	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
157239002618	CAP-like domain; other site
157239002619	active site
157239002620	primary dimer interface [polypeptide binding]; other site
157239002621	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
157239002622	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
157239002623	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
157239002624	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
157239002625	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
157239002626	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
157239002627	uncharacterized domain; Region: TIGR00702
157239002628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239002629	S-adenosylmethionine binding site [chemical binding]; other site
157239002630	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
157239002631	tellurite resistance protein TehB; Provisional; Region: PRK12335
157239002632	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
157239002633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239002634	S-adenosylmethionine binding site [chemical binding]; other site
157239002635	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
157239002636	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
157239002637	active site
157239002638	HIGH motif; other site
157239002639	KMSKS motif; other site
157239002640	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
157239002641	tRNA binding surface [nucleotide binding]; other site
157239002642	anticodon binding site; other site
157239002643	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
157239002644	dimer interface [polypeptide binding]; other site
157239002645	putative tRNA-binding site [nucleotide binding]; other site
157239002646	antiporter inner membrane protein; Provisional; Region: PRK11670
157239002647	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
157239002648	Walker A motif; other site
157239002649	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
157239002650	dimer interface [polypeptide binding]; other site
157239002651	FMN binding site [chemical binding]; other site
157239002652	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
157239002653	ligand binding site; other site
157239002654	tetramer interface; other site
157239002655	hypothetical protein; Provisional; Region: PRK14641
157239002656	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
157239002657	putative oligomer interface [polypeptide binding]; other site
157239002658	putative RNA binding site [nucleotide binding]; other site
157239002659	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
157239002660	NusA N-terminal domain; Region: NusA_N; pfam08529
157239002661	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
157239002662	RNA binding site [nucleotide binding]; other site
157239002663	homodimer interface [polypeptide binding]; other site
157239002664	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
157239002665	G-X-X-G motif; other site
157239002666	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
157239002667	G-X-X-G motif; other site
157239002668	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
157239002669	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
157239002670	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
157239002671	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
157239002672	translation initiation factor IF-2; Validated; Region: infB; PRK05306
157239002673	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
157239002674	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
157239002675	G1 box; other site
157239002676	putative GEF interaction site [polypeptide binding]; other site
157239002677	GTP/Mg2+ binding site [chemical binding]; other site
157239002678	Switch I region; other site
157239002679	G2 box; other site
157239002680	G3 box; other site
157239002681	Switch II region; other site
157239002682	G4 box; other site
157239002683	G5 box; other site
157239002684	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
157239002685	Translation-initiation factor 2; Region: IF-2; pfam11987
157239002686	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
157239002687	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
157239002688	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
157239002689	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239002690	ATP binding site [chemical binding]; other site
157239002691	putative Mg++ binding site [ion binding]; other site
157239002692	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
157239002693	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
157239002694	Abortive infection C-terminus; Region: Abi_C; pfam14355
157239002695	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
157239002696	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
157239002697	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
157239002698	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
157239002699	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
157239002700	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
157239002701	RNA binding site [nucleotide binding]; other site
157239002702	active site
157239002703	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
157239002704	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
157239002705	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
157239002706	prephenate dehydrogenase; Validated; Region: PRK08507
157239002707	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
157239002708	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
157239002709	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
157239002710	Zn-ribbon-containing, possibly nucleic-acid-binding protein [General function prediction only]; Region: COG5595
157239002711	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
157239002712	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
157239002713	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
157239002714	catalytic residue [active]
157239002715	Staphylococcal nuclease homologues; Region: SNc; smart00318
157239002716	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
157239002717	Catalytic site; other site
157239002718	hypothetical protein; Provisional; Region: PRK01821
157239002719	TIGR00659 family protein; Region: TIGR00659
157239002720	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
157239002721	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
157239002722	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
157239002723	ABC transporter ATPase component; Reviewed; Region: PRK11147
157239002724	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
157239002725	ABC transporter; Region: ABC_tran_2; pfam12848
157239002726	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
157239002727	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
157239002728	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
157239002729	active site clefts [active]
157239002730	zinc binding site [ion binding]; other site
157239002731	dimer interface [polypeptide binding]; other site
157239002732	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
157239002733	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
157239002734	putative dimer interface [polypeptide binding]; other site
157239002735	putative anticodon binding site; other site
157239002736	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
157239002737	homodimer interface [polypeptide binding]; other site
157239002738	motif 1; other site
157239002739	motif 2; other site
157239002740	active site
157239002741	motif 3; other site
157239002742	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
157239002743	homopentamer interface [polypeptide binding]; other site
157239002744	active site
157239002745	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
157239002746	putative RNA binding site [nucleotide binding]; other site
157239002747	thiamine-monophosphate kinase; Region: thiL; TIGR01379
157239002748	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
157239002749	ATP binding site [chemical binding]; other site
157239002750	dimerization interface [polypeptide binding]; other site
157239002751	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
157239002752	tetramer interfaces [polypeptide binding]; other site
157239002753	binuclear metal-binding site [ion binding]; other site
157239002754	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
157239002755	dihydrodipicolinate reductase; Region: dapB; TIGR00036
157239002756	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
157239002757	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
157239002758	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
157239002759	catalytic loop [active]
157239002760	iron binding site [ion binding]; other site
157239002761	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
157239002762	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
157239002763	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
157239002764	dimer interface [polypeptide binding]; other site
157239002765	motif 1; other site
157239002766	active site
157239002767	motif 2; other site
157239002768	motif 3; other site
157239002769	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
157239002770	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
157239002771	putative tRNA-binding site [nucleotide binding]; other site
157239002772	B3/4 domain; Region: B3_4; pfam03483
157239002773	tRNA synthetase B5 domain; Region: B5; smart00874
157239002774	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
157239002775	dimer interface [polypeptide binding]; other site
157239002776	motif 1; other site
157239002777	motif 3; other site
157239002778	motif 2; other site
157239002779	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
157239002780	Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835
157239002781	DNA binding site [nucleotide binding]
157239002782	dimer interface [polypeptide binding]; other site
157239002783	NlpC/P60 family; Region: NLPC_P60; pfam00877
157239002784	Predicted transcriptional regulator [Transcription]; Region: COG2378
157239002785	WYL domain; Region: WYL; pfam13280
157239002786	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
157239002787	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
157239002788	NAD+ binding site [chemical binding]; other site
157239002789	substrate binding site [chemical binding]; other site
157239002790	Zn binding site [ion binding]; other site
157239002791	Virulence protein RhuM family; Region: Virulence_RhuM; cl19850
157239002792	Fic/DOC family; Region: Fic; pfam02661
157239002793	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
157239002794	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
157239002795	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
157239002796	active site
157239002797	Protein of unknown function DUF262; Region: DUF262; pfam03235
157239002798	Protein of unknown function DUF262; Region: DUF262; pfam03235
157239002799	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
157239002800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239002801	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
157239002802	Walker A motif; other site
157239002803	ATP binding site [chemical binding]; other site
157239002804	Walker B motif; other site
157239002805	arginine finger; other site
157239002806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239002807	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
157239002808	Walker A motif; other site
157239002809	ATP binding site [chemical binding]; other site
157239002810	Walker B motif; other site
157239002811	arginine finger; other site
157239002812	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
157239002813	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
157239002814	active site
157239002815	phosphate binding residues; other site
157239002816	catalytic residues [active]
157239002817	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
157239002818	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
157239002819	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
157239002820	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
157239002821	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
157239002822	23S rRNA binding site [nucleotide binding]; other site
157239002823	L21 binding site [polypeptide binding]; other site
157239002824	L13 binding site [polypeptide binding]; other site
157239002825	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
157239002826	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
157239002827	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
157239002828	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
157239002829	AAA domain; Region: AAA_30; pfam13604
157239002830	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
157239002831	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
157239002832	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
157239002833	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
157239002834	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
157239002835	active site 1 [active]
157239002836	dimer interface [polypeptide binding]; other site
157239002837	active site 2 [active]
157239002838	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
157239002839	ATP binding site [chemical binding]; other site
157239002840	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
157239002841	16S/18S rRNA binding site [nucleotide binding]; other site
157239002842	S13e-L30e interaction site [polypeptide binding]; other site
157239002843	25S rRNA binding site [nucleotide binding]; other site
157239002844	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
157239002845	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
157239002846	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
157239002847	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
157239002848	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
157239002849	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
157239002850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239002851	S-adenosylmethionine binding site [chemical binding]; other site
157239002852	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
157239002853	FtsH Extracellular; Region: FtsH_ext; pfam06480
157239002854	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239002855	Walker A motif; other site
157239002856	ATP binding site [chemical binding]; other site
157239002857	Walker B motif; other site
157239002858	arginine finger; other site
157239002859	Peptidase family M41; Region: Peptidase_M41; pfam01434
157239002860	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
157239002861	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
157239002862	substrate binding pocket [chemical binding]; other site
157239002863	dimer interface [polypeptide binding]; other site
157239002864	inhibitor binding site; inhibition site
157239002865	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
157239002866	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
157239002867	active site
157239002868	substrate binding site [chemical binding]; other site
157239002869	metal binding site [ion binding]; metal-binding site
157239002870	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
157239002871	catalytic core [active]
157239002872	Rotavirus VP2 protein; Region: Rota_VP2; pfam05087
157239002873	Late embryogenesis abundant protein; Region: LEA_4; pfam02987
157239002874	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
157239002875	Outer membrane efflux protein; Region: OEP; pfam02321
157239002876	Outer membrane efflux protein; Region: OEP; pfam02321
157239002877	RNA polymerase sigma factor; Provisional; Region: PRK12530
157239002878	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
157239002879	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
157239002880	DNA binding residues [nucleotide binding]
157239002881	Putative zinc-finger; Region: zf-HC2; pfam13490
157239002882	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
157239002883	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239002884	non-specific DNA binding site [nucleotide binding]; other site
157239002885	salt bridge; other site
157239002886	sequence-specific DNA binding site [nucleotide binding]; other site
157239002887	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
157239002888	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
157239002889	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
157239002890	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
157239002891	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
157239002892	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
157239002893	catalytic residues [active]
157239002894	dsDNA-mimic protein; Reviewed; Region: PRK05094
157239002895	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
157239002896	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
157239002897	ATP binding site [chemical binding]; other site
157239002898	substrate interface [chemical binding]; other site
157239002899	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
157239002900	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
157239002901	dimer interface [polypeptide binding]; other site
157239002902	putative functional site; other site
157239002903	putative MPT binding site; other site
157239002904	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
157239002905	homodecamer interface [polypeptide binding]; other site
157239002906	active site
157239002907	putative catalytic site residues [active]
157239002908	zinc binding site [ion binding]; other site
157239002909	GTP-CH-I/GFRP interaction surface; other site
157239002910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
157239002911	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
157239002912	AAA domain; Region: AAA_26; pfam13500
157239002913	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
157239002914	FAD binding site [chemical binding]; other site
157239002915	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
157239002916	23S rRNA interface [nucleotide binding]; other site
157239002917	L3 interface [polypeptide binding]; other site
157239002918	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
157239002919	stringent starvation protein A; Provisional; Region: sspA; PRK09481
157239002920	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
157239002921	C-terminal domain interface [polypeptide binding]; other site
157239002922	putative GSH binding site (G-site) [chemical binding]; other site
157239002923	dimer interface [polypeptide binding]; other site
157239002924	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
157239002925	dimer interface [polypeptide binding]; other site
157239002926	N-terminal domain interface [polypeptide binding]; other site
157239002927	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
157239002928	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
157239002929	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
157239002930	TPP-binding site; other site
157239002931	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
157239002932	PYR/PP interface [polypeptide binding]; other site
157239002933	dimer interface [polypeptide binding]; other site
157239002934	TPP binding site [chemical binding]; other site
157239002935	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
157239002936	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
157239002937	substrate binding pocket [chemical binding]; other site
157239002938	chain length determination region; other site
157239002939	substrate-Mg2+ binding site; other site
157239002940	catalytic residues [active]
157239002941	aspartate-rich region 1; other site
157239002942	active site lid residues [active]
157239002943	aspartate-rich region 2; other site
157239002944	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
157239002945	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
157239002946	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
157239002947	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
157239002948	Ligand Binding Site [chemical binding]; other site
157239002949	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
157239002950	active site residue [active]
157239002951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
157239002952	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
157239002953	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
157239002954	probable active site [active]
157239002955	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3140
157239002956	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
157239002957	DNA-binding site [nucleotide binding]; DNA binding site
157239002958	RNA-binding motif; other site
157239002959	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
157239002960	putative deacylase active site [active]
157239002961	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
157239002962	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
157239002963	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
157239002964	substrate binding site [chemical binding]; other site
157239002965	active site
157239002966	catalytic residues [active]
157239002967	heterodimer interface [polypeptide binding]; other site
157239002968	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
157239002969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239002970	catalytic residue [active]
157239002971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
157239002972	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
157239002973	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
157239002974	dimerization interface [polypeptide binding]; other site
157239002975	putative ATP binding site [chemical binding]; other site
157239002976	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
157239002977	active site
157239002978	substrate binding site [chemical binding]; other site
157239002979	cosubstrate binding site; other site
157239002980	catalytic site [active]
157239002981	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
157239002982	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
157239002983	universal stress protein UspE; Provisional; Region: PRK11175
157239002984	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
157239002985	Ligand Binding Site [chemical binding]; other site
157239002986	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
157239002987	Ligand Binding Site [chemical binding]; other site
157239002988	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
157239002989	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
157239002990	ligand binding site [chemical binding]; other site
157239002991	flexible hinge region; other site
157239002992	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
157239002993	putative switch regulator; other site
157239002994	non-specific DNA interactions [nucleotide binding]; other site
157239002995	DNA binding site [nucleotide binding]
157239002996	sequence specific DNA binding site [nucleotide binding]; other site
157239002997	putative cAMP binding site [chemical binding]; other site
157239002998	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
157239002999	DNA binding site [nucleotide binding]
157239003000	active site
157239003001	Int/Topo IB signature motif; other site
157239003002	lac repressor; Reviewed; Region: lacI; PRK09526
157239003003	AntA/AntB antirepressor; Region: AntA; pfam08346
157239003004	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
157239003005	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
157239003006	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
157239003007	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
157239003008	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
157239003009	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239003010	non-specific DNA binding site [nucleotide binding]; other site
157239003011	salt bridge; other site
157239003012	sequence-specific DNA binding site [nucleotide binding]; other site
157239003013	Predicted transcriptional regulator [Transcription]; Region: COG2932
157239003014	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
157239003015	Catalytic site [active]
157239003016	DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770
157239003017	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
157239003018	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
157239003019	Helix-turn-helix domain; Region: HTH_36; pfam13730
157239003020	Replication protein P; Region: Phage_lambda_P; pfam06992
157239003021	NinB protein; Region: NinB; pfam05772
157239003022	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
157239003023	active site
157239003024	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
157239003025	P63C domain; Region: P63C; pfam10546
157239003026	Prophage antirepressor [Transcription]; Region: COG3617
157239003027	BRO family, N-terminal domain; Region: Bro-N; pfam02498
157239003028	P22AR C-terminal domain; Region: P22_AR_C; pfam10548
157239003029	phage holin, lambda family; Region: holin_lambda; TIGR01594
157239003030	Predicted chitinase [General function prediction only]; Region: COG3179
157239003031	catalytic residue [active]
157239003032	Protein of unknown function (DUF2570); Region: DUF2570; pfam10828
157239003033	Terminase small subunit; Region: Terminase_2; pfam03592
157239003034	Phage terminase large subunit; Region: Terminase_3; cl12054
157239003035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567
157239003036	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842
157239003037	dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036
157239003038	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
157239003039	quinone interaction residues [chemical binding]; other site
157239003040	active site
157239003041	catalytic residues [active]
157239003042	FMN binding site [chemical binding]; other site
157239003043	substrate binding site [chemical binding]; other site
157239003044	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
157239003045	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
157239003046	active site
157239003047	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
157239003048	fumarate hydratase; Reviewed; Region: fumC; PRK00485
157239003049	Class II fumarases; Region: Fumarase_classII; cd01362
157239003050	active site
157239003051	tetramer interface [polypeptide binding]; other site
157239003052	DNA polymerase III subunit chi; Validated; Region: PRK05728
157239003053	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
157239003054	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
157239003055	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
157239003056	active site
157239003057	HIGH motif; other site
157239003058	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
157239003059	KMSKS motif; other site
157239003060	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
157239003061	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
157239003062	tRNA binding surface [nucleotide binding]; other site
157239003063	anticodon binding site; other site
157239003064	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
157239003065	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
157239003066	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
157239003067	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
157239003068	active site
157239003069	ribulose/triose binding site [chemical binding]; other site
157239003070	phosphate binding site [ion binding]; other site
157239003071	substrate (anthranilate) binding pocket [chemical binding]; other site
157239003072	product (indole) binding pocket [chemical binding]; other site
157239003073	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
157239003074	active site
157239003075	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
157239003076	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
157239003077	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
157239003078	Tautomerase enzyme; Region: Tautomerase_2; pfam14552
157239003079	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
157239003080	Glutamine amidotransferase class-I; Region: GATase; pfam00117
157239003081	glutamine binding [chemical binding]; other site
157239003082	catalytic triad [active]
157239003083	anthranilate synthase component I; Provisional; Region: PRK13564
157239003084	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
157239003085	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
157239003086	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
157239003087	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
157239003088	Ferritin-like domain; Region: Ferritin; pfam00210
157239003089	ferroxidase diiron center [ion binding]; other site
157239003090	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
157239003091	Ferritin-like domain; Region: Ferritin; pfam00210
157239003092	ferroxidase diiron center [ion binding]; other site
157239003093	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
157239003094	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
157239003095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003096	dimer interface [polypeptide binding]; other site
157239003097	conserved gate region; other site
157239003098	putative PBP binding loops; other site
157239003099	ABC-ATPase subunit interface; other site
157239003100	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
157239003101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003102	dimer interface [polypeptide binding]; other site
157239003103	conserved gate region; other site
157239003104	putative PBP binding loops; other site
157239003105	ABC-ATPase subunit interface; other site
157239003106	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
157239003107	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
157239003108	Walker A/P-loop; other site
157239003109	ATP binding site [chemical binding]; other site
157239003110	Q-loop/lid; other site
157239003111	ABC transporter signature motif; other site
157239003112	Walker B; other site
157239003113	D-loop; other site
157239003114	H-loop/switch region; other site
157239003115	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
157239003116	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
157239003117	active site
157239003118	phosphorylation site [posttranslational modification]
157239003119	intermolecular recognition site; other site
157239003120	dimerization interface [polypeptide binding]; other site
157239003121	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
157239003122	DNA binding site [nucleotide binding]
157239003123	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
157239003124	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
157239003125	putative active site [active]
157239003126	heme pocket [chemical binding]; other site
157239003127	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
157239003128	dimer interface [polypeptide binding]; other site
157239003129	phosphorylation site [posttranslational modification]
157239003130	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
157239003131	ATP binding site [chemical binding]; other site
157239003132	Mg2+ binding site [ion binding]; other site
157239003133	G-X-G motif; other site
157239003134	exonuclease I; Provisional; Region: sbcB; PRK11779
157239003135	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
157239003136	active site
157239003137	catalytic site [active]
157239003138	substrate binding site [chemical binding]; other site
157239003139	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
157239003140	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
157239003141	Uncharacterized conserved protein [Function unknown]; Region: COG3586
157239003142	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
157239003143	P-loop containing region of AAA domain; Region: AAA_29; cl17516
157239003144	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
157239003145	condesin subunit E; Provisional; Region: PRK05256
157239003146	KicB killing factor; Region: KicB; pfam03882
157239003147	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
157239003148	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
157239003149	Ligand Binding Site [chemical binding]; other site
157239003150	DsrC like protein; Region: DsrC; pfam04358
157239003151	molybdenum-pterin binding domain; Region: Mop; TIGR00638
157239003152	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
157239003153	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
157239003154	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
157239003155	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
157239003156	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
157239003157	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
157239003158	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
157239003159	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
157239003160	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
157239003161	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
157239003162	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
157239003163	active site
157239003164	dimer interface [polypeptide binding]; other site
157239003165	motif 1; other site
157239003166	motif 2; other site
157239003167	motif 3; other site
157239003168	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
157239003169	anticodon binding site; other site
157239003170	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
157239003171	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
157239003172	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
157239003173	active site
157239003174	interdomain interaction site; other site
157239003175	putative metal-binding site [ion binding]; other site
157239003176	nucleotide binding site [chemical binding]; other site
157239003177	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
157239003178	domain I; other site
157239003179	DNA binding groove [nucleotide binding]
157239003180	phosphate binding site [ion binding]; other site
157239003181	domain II; other site
157239003182	domain III; other site
157239003183	nucleotide binding site [chemical binding]; other site
157239003184	catalytic site [active]
157239003185	domain IV; other site
157239003186	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
157239003187	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
157239003188	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
157239003189	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
157239003190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
157239003191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
157239003192	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
157239003193	putative effector binding pocket; other site
157239003194	dimerization interface [polypeptide binding]; other site
157239003195	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
157239003196	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
157239003197	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
157239003198	ligand binding site [chemical binding]; other site
157239003199	homodimer interface [polypeptide binding]; other site
157239003200	NAD(P) binding site [chemical binding]; other site
157239003201	trimer interface B [polypeptide binding]; other site
157239003202	trimer interface A [polypeptide binding]; other site
157239003203	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
157239003204	glycogen phosphorylase; Provisional; Region: PRK14986
157239003205	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
157239003206	homodimer interface [polypeptide binding]; other site
157239003207	active site pocket [active]
157239003208	glycogen synthase; Provisional; Region: glgA; PRK00654
157239003209	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
157239003210	ADP-binding pocket [chemical binding]; other site
157239003211	homodimer interface [polypeptide binding]; other site
157239003212	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
157239003213	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
157239003214	ligand binding site; other site
157239003215	oligomer interface; other site
157239003216	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
157239003217	dimer interface [polypeptide binding]; other site
157239003218	N-terminal domain interface [polypeptide binding]; other site
157239003219	sulfate 1 binding site; other site
157239003220	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
157239003221	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
157239003222	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
157239003223	active site
157239003224	catalytic site [active]
157239003225	glycogen branching enzyme; Provisional; Region: PRK05402
157239003226	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
157239003227	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
157239003228	active site
157239003229	catalytic site [active]
157239003230	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
157239003231	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
157239003232	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
157239003233	Uncharacterized conserved protein [Function unknown]; Region: COG2983
157239003234	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
157239003235	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
157239003236	active site
157239003237	HIGH motif; other site
157239003238	KMSKS motif; other site
157239003239	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
157239003240	ribonuclease G; Provisional; Region: PRK11712
157239003241	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
157239003242	homodimer interface [polypeptide binding]; other site
157239003243	oligonucleotide binding site [chemical binding]; other site
157239003244	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
157239003245	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
157239003246	Na binding site [ion binding]; other site
157239003247	tRNA (mo5U34)-methyltransferase; Region: TIGR00452
157239003248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239003249	S-adenosylmethionine binding site [chemical binding]; other site
157239003250	cytidine deaminase; Provisional; Region: PRK09027
157239003251	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
157239003252	active site
157239003253	catalytic motif [active]
157239003254	Zn binding site [ion binding]; other site
157239003255	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
157239003256	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
157239003257	active site
157239003258	catalytic motif [active]
157239003259	Zn binding site [ion binding]; other site
157239003260	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
157239003261	Ferritin-like domain; Region: Ferritin; pfam00210
157239003262	dimerization interface [polypeptide binding]; other site
157239003263	DPS ferroxidase diiron center [ion binding]; other site
157239003264	ion pore; other site
157239003265	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
157239003266	peptidase T-like protein; Region: PepT-like; TIGR01883
157239003267	metal binding site [ion binding]; metal-binding site
157239003268	dimer interface [polypeptide binding]; other site
157239003269	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
157239003270	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
157239003271	Walker A/P-loop; other site
157239003272	ATP binding site [chemical binding]; other site
157239003273	Q-loop/lid; other site
157239003274	ABC transporter signature motif; other site
157239003275	Walker B; other site
157239003276	D-loop; other site
157239003277	H-loop/switch region; other site
157239003278	TOBE domain; Region: TOBE_2; pfam08402
157239003279	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
157239003280	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003281	dimer interface [polypeptide binding]; other site
157239003282	conserved gate region; other site
157239003283	putative PBP binding loops; other site
157239003284	ABC-ATPase subunit interface; other site
157239003285	spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500
157239003286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003287	dimer interface [polypeptide binding]; other site
157239003288	conserved gate region; other site
157239003289	putative PBP binding loops; other site
157239003290	ABC-ATPase subunit interface; other site
157239003291	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
157239003292	Abortive infection C-terminus; Region: Abi_C; pfam14355
157239003293	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
157239003294	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
157239003295	putative ribose interaction site [chemical binding]; other site
157239003296	putative ADP binding site [chemical binding]; other site
157239003297	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
157239003298	active site
157239003299	nucleotide binding site [chemical binding]; other site
157239003300	HIGH motif; other site
157239003301	KMSKS motif; other site
157239003302	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
157239003303	putative acyl-acceptor binding pocket; other site
157239003304	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
157239003305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
157239003306	ATP binding site [chemical binding]; other site
157239003307	Mg2+ binding site [ion binding]; other site
157239003308	G-X-G motif; other site
157239003309	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
157239003310	anchoring element; other site
157239003311	dimer interface [polypeptide binding]; other site
157239003312	ATP binding site [chemical binding]; other site
157239003313	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
157239003314	active site
157239003315	metal binding site [ion binding]; metal-binding site
157239003316	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
157239003317	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
157239003318	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
157239003319	CAP-like domain; other site
157239003320	active site
157239003321	primary dimer interface [polypeptide binding]; other site
157239003322	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
157239003323	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
157239003324	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
157239003325	RimK-like ATP-grasp domain; Region: RimK; pfam08443
157239003326	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
157239003327	GSH binding site [chemical binding]; other site
157239003328	catalytic residues [active]
157239003329	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
157239003330	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
157239003331	dimer interface [polypeptide binding]; other site
157239003332	active site
157239003333	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
157239003334	Uncharacterized conserved protein [Function unknown]; Region: COG4121
157239003335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
157239003336	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
157239003337	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
157239003338	active site
157239003339	ATP binding site [chemical binding]; other site
157239003340	Phosphotransferase enzyme family; Region: APH; pfam01636
157239003341	substrate binding site [chemical binding]; other site
157239003342	dimer interface [polypeptide binding]; other site
157239003343	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
157239003344	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
157239003345	EamA-like transporter family; Region: EamA; pfam00892
157239003346	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
157239003347	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
157239003348	active site
157239003349	metal-binding site
157239003350	LicD family; Region: LicD; cl01378
157239003351	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
157239003352	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
157239003353	tandem repeat interface [polypeptide binding]; other site
157239003354	oligomer interface [polypeptide binding]; other site
157239003355	active site residues [active]
157239003356	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
157239003357	tandem repeat interface [polypeptide binding]; other site
157239003358	oligomer interface [polypeptide binding]; other site
157239003359	active site residues [active]
157239003360	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
157239003361	putative FMN binding site [chemical binding]; other site
157239003362	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
157239003363	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
157239003364	serine/threonine transporter SstT; Provisional; Region: PRK13628
157239003365	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
157239003366	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
157239003367	Catalytic site [active]
157239003368	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
157239003369	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
157239003370	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
157239003371	FtsX-like permease family; Region: FtsX; pfam02687
157239003372	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
157239003373	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
157239003374	Walker A/P-loop; other site
157239003375	ATP binding site [chemical binding]; other site
157239003376	Q-loop/lid; other site
157239003377	ABC transporter signature motif; other site
157239003378	Walker B; other site
157239003379	D-loop; other site
157239003380	H-loop/switch region; other site
157239003381	AAA domain; Region: AAA_26; pfam13500
157239003382	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
157239003383	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
157239003384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239003385	S-adenosylmethionine binding site [chemical binding]; other site
157239003386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2830
157239003387	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
157239003388	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
157239003389	substrate-cofactor binding pocket; other site
157239003390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239003391	catalytic residue [active]
157239003392	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
157239003393	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
157239003394	inhibitor-cofactor binding pocket; inhibition site
157239003395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239003396	catalytic residue [active]
157239003397	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
157239003398	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
157239003399	FtsX-like permease family; Region: FtsX; pfam02687
157239003400	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
157239003401	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
157239003402	putative ligand binding site [chemical binding]; other site
157239003403	putative NAD binding site [chemical binding]; other site
157239003404	catalytic site [active]
157239003405	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
157239003406	Uncharacterized conserved protein [Function unknown]; Region: COG2912
157239003407	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
157239003408	HemK family putative methylases; Region: hemK_fam; TIGR00536
157239003409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239003410	S-adenosylmethionine binding site [chemical binding]; other site
157239003411	RDD family; Region: RDD; pfam06271
157239003412	peptide chain release factor 1; Validated; Region: prfA; PRK00591
157239003413	This domain is found in peptide chain release factors; Region: PCRF; smart00937
157239003414	RF-1 domain; Region: RF-1; pfam00472
157239003415	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
157239003416	Sel1-like repeats; Region: SEL1; smart00671
157239003417	Sel1-like repeats; Region: SEL1; smart00671
157239003418	Sel1-like repeats; Region: SEL1; smart00671
157239003419	Sel1-like repeats; Region: SEL1; smart00671
157239003420	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
157239003421	Sel1-like repeats; Region: SEL1; smart00671
157239003422	Sel1-like repeats; Region: SEL1; smart00671
157239003423	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
157239003424	Sel1-like repeats; Region: SEL1; smart00671
157239003425	Sel1-like repeats; Region: SEL1; smart00671
157239003426	Sel1-like repeats; Region: SEL1; smart00671
157239003427	Sel1-like repeats; Region: SEL1; smart00671
157239003428	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
157239003429	Sel1-like repeats; Region: SEL1; smart00671
157239003430	Sel1-like repeats; Region: SEL1; smart00671
157239003431	Protein of unknown function, DUF462; Region: DUF462; cl01190
157239003432	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
157239003433	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
157239003434	pyruvate kinase; Provisional; Region: PRK05826
157239003435	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
157239003436	domain interfaces; other site
157239003437	active site
157239003438	replicative DNA helicase; Validated; Region: PRK06904
157239003439	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
157239003440	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
157239003441	Walker A motif; other site
157239003442	ATP binding site [chemical binding]; other site
157239003443	Walker B motif; other site
157239003444	DNA binding loops [nucleotide binding]
157239003445	alanine racemase; Reviewed; Region: alr; PRK00053
157239003446	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
157239003447	active site
157239003448	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
157239003449	substrate binding site [chemical binding]; other site
157239003450	catalytic residues [active]
157239003451	dimer interface [polypeptide binding]; other site
157239003452	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
157239003453	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
157239003454	active site
157239003455	dimer interface [polypeptide binding]; other site
157239003456	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
157239003457	dimer interface [polypeptide binding]; other site
157239003458	active site
157239003459	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
157239003460	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
157239003461	active site
157239003462	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
157239003463	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
157239003464	putative metal binding site [ion binding]; other site
157239003465	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
157239003466	arginyl-tRNA synthetase; Region: argS; TIGR00456
157239003467	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
157239003468	active site
157239003469	HIGH motif; other site
157239003470	KMSK motif region; other site
157239003471	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
157239003472	tRNA binding surface [nucleotide binding]; other site
157239003473	anticodon binding site; other site
157239003474	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
157239003475	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
157239003476	putative valine binding site [chemical binding]; other site
157239003477	dimer interface [polypeptide binding]; other site
157239003478	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
157239003479	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882
157239003480	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
157239003481	PYR/PP interface [polypeptide binding]; other site
157239003482	dimer interface [polypeptide binding]; other site
157239003483	TPP binding site [chemical binding]; other site
157239003484	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
157239003485	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
157239003486	TPP-binding site [chemical binding]; other site
157239003487	dimer interface [polypeptide binding]; other site
157239003488	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
157239003489	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
157239003490	Domain in histone-like proteins of HNS family; Region: HNS; cl19571
157239003491	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
157239003492	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
157239003493	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
157239003494	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
157239003495	putative active site [active]
157239003496	putative substrate binding site [chemical binding]; other site
157239003497	putative cosubstrate binding site; other site
157239003498	catalytic site [active]
157239003499	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
157239003500	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
157239003501	hinge; other site
157239003502	active site
157239003503	recombination factor protein RarA; Reviewed; Region: PRK13342
157239003504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239003505	Walker A motif; other site
157239003506	ATP binding site [chemical binding]; other site
157239003507	Walker B motif; other site
157239003508	arginine finger; other site
157239003509	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
157239003510	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192
157239003511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239003512	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
157239003513	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
157239003514	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
157239003515	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
157239003516	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
157239003517	putative DNA binding site [nucleotide binding]; other site
157239003518	dimerization interface [polypeptide binding]; other site
157239003519	putative Zn2+ binding site [ion binding]; other site
157239003520	AsnC family; Region: AsnC_trans_reg; pfam01037
157239003521	DNA repair protein RadA; Region: sms; TIGR00416
157239003522	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
157239003523	Walker A motif/ATP binding site; other site
157239003524	ATP binding site [chemical binding]; other site
157239003525	Walker B motif; other site
157239003526	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
157239003527	Uncharacterized conserved protein [Function unknown]; Region: COG3025
157239003528	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
157239003529	putative active site [active]
157239003530	putative metal binding residues [ion binding]; other site
157239003531	signature motif; other site
157239003532	putative triphosphate binding site [ion binding]; other site
157239003533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219
157239003534	Protein of unknown function (DUF692); Region: DUF692; pfam05114
157239003535	Uncharacterized low-complexity protein [Function unknown]; Region: COG3767
157239003536	Predicted membrane protein [Function unknown]; Region: COG2259
157239003537	TIGR00153 family protein; Region: TIGR00153
157239003538	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
157239003539	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
157239003540	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
157239003541	Bacterial SH3 domain homologues; Region: SH3b; smart00287
157239003542	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
157239003543	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
157239003544	active site
157239003545	NTP binding site [chemical binding]; other site
157239003546	metal binding triad [ion binding]; metal-binding site
157239003547	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
157239003548	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
157239003549	Zn2+ binding site [ion binding]; other site
157239003550	Mg2+ binding site [ion binding]; other site
157239003551	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
157239003552	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
157239003553	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
157239003554	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
157239003555	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
157239003556	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
157239003557	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239003558	active site
157239003559	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
157239003560	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
157239003561	active site
157239003562	HIGH motif; other site
157239003563	dimer interface [polypeptide binding]; other site
157239003564	KMSKS motif; other site
157239003565	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
157239003566	RNA binding surface [nucleotide binding]; other site
157239003567	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
157239003568	multidrug efflux protein; Reviewed; Region: PRK01766
157239003569	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
157239003570	cation binding site [ion binding]; other site
157239003571	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
157239003572	Lumazine binding domain; Region: Lum_binding; pfam00677
157239003573	Lumazine binding domain; Region: Lum_binding; pfam00677
157239003574	aminopeptidase N; Provisional; Region: pepN; PRK14015
157239003575	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
157239003576	active site
157239003577	Zn binding site [ion binding]; other site
157239003578	Fimbrial protein; Region: Fimbrial; pfam00419
157239003579	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
157239003580	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
157239003581	PapC N-terminal domain; Region: PapC_N; pfam13954
157239003582	Outer membrane usher protein; Region: Usher; pfam00577
157239003583	PapC C-terminal domain; Region: PapC_C; pfam13953
157239003584	putative chaperone protein EcpD; Provisional; Region: PRK09926
157239003585	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
157239003586	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
157239003587	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
157239003588	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
157239003589	HicB family; Region: HicB; pfam05534
157239003590	YcfA-like protein; Region: YcfA; pfam07927
157239003591	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
157239003592	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
157239003593	ATP-grasp domain; Region: ATP-grasp; pfam02222
157239003594	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
157239003595	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
157239003596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239003597	homodimer interface [polypeptide binding]; other site
157239003598	catalytic residue [active]
157239003599	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
157239003600	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
157239003601	Walker A/P-loop; other site
157239003602	ATP binding site [chemical binding]; other site
157239003603	Q-loop/lid; other site
157239003604	ABC transporter signature motif; other site
157239003605	Walker B; other site
157239003606	D-loop; other site
157239003607	H-loop/switch region; other site
157239003608	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
157239003609	cobalt transport protein CbiM; Validated; Region: PRK06265
157239003610	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
157239003611	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
157239003612	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
157239003613	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
157239003614	DNA binding residues [nucleotide binding]
157239003615	dimer interface [polypeptide binding]; other site
157239003616	putative metal binding site [ion binding]; other site
157239003617	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
157239003618	Sel1-like repeats; Region: SEL1; smart00671
157239003619	Sel1-like repeats; Region: SEL1; smart00671
157239003620	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
157239003621	YwiC-like protein; Region: YwiC; pfam14256
157239003622	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
157239003623	homotrimer interaction site [polypeptide binding]; other site
157239003624	putative active site [active]
157239003625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
157239003626	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
157239003627	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
157239003628	5S rRNA interface [nucleotide binding]; other site
157239003629	CTC domain interface [polypeptide binding]; other site
157239003630	L16 interface [polypeptide binding]; other site
157239003631	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
157239003632	substrate binding site [chemical binding]; other site
157239003633	nucleotide binding site [chemical binding]; other site
157239003634	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
157239003635	dimer interface [polypeptide binding]; other site
157239003636	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
157239003637	GDP-binding site [chemical binding]; other site
157239003638	ACT binding site; other site
157239003639	IMP binding site; other site
157239003640	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
157239003641	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
157239003642	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
157239003643	trimer interface [polypeptide binding]; other site
157239003644	active site
157239003645	substrate binding site [chemical binding]; other site
157239003646	CoA binding site [chemical binding]; other site
157239003647	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
157239003648	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
157239003649	DNA binding site [nucleotide binding]
157239003650	domain linker motif; other site
157239003651	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
157239003652	dimerization interface [polypeptide binding]; other site
157239003653	ligand binding site [chemical binding]; other site
157239003654	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
157239003655	Predicted ATPase [General function prediction only]; Region: COG3106
157239003656	antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109
157239003657	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
157239003658	peptide binding site [polypeptide binding]; other site
157239003659	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
157239003660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003661	dimer interface [polypeptide binding]; other site
157239003662	conserved gate region; other site
157239003663	putative PBP binding loops; other site
157239003664	ABC-ATPase subunit interface; other site
157239003665	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
157239003666	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
157239003667	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003668	dimer interface [polypeptide binding]; other site
157239003669	conserved gate region; other site
157239003670	putative PBP binding loops; other site
157239003671	ABC-ATPase subunit interface; other site
157239003672	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
157239003673	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
157239003674	Walker A/P-loop; other site
157239003675	ATP binding site [chemical binding]; other site
157239003676	Q-loop/lid; other site
157239003677	ABC transporter signature motif; other site
157239003678	Walker B; other site
157239003679	D-loop; other site
157239003680	H-loop/switch region; other site
157239003681	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
157239003682	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
157239003683	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
157239003684	Walker A/P-loop; other site
157239003685	ATP binding site [chemical binding]; other site
157239003686	Q-loop/lid; other site
157239003687	ABC transporter signature motif; other site
157239003688	Walker B; other site
157239003689	D-loop; other site
157239003690	H-loop/switch region; other site
157239003691	conserved hypothetical integral membrane protein; Region: TIGR00698
157239003692	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
157239003693	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
157239003694	dimerization interface 3.5A [polypeptide binding]; other site
157239003695	active site
157239003696	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
157239003697	AMP binding site [chemical binding]; other site
157239003698	metal binding site [ion binding]; metal-binding site
157239003699	active site
157239003700	L-lactate transport; Region: lctP; TIGR00795
157239003701	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
157239003702	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
157239003703	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
157239003704	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
157239003705	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
157239003706	catalytic residues [active]
157239003707	hinge region; other site
157239003708	alpha helical domain; other site
157239003709	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
157239003710	DHH family; Region: DHH; pfam01368
157239003711	DHHA1 domain; Region: DHHA1; pfam02272
157239003712	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
157239003713	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
157239003714	dimerization domain [polypeptide binding]; other site
157239003715	dimer interface [polypeptide binding]; other site
157239003716	catalytic residues [active]
157239003717	peptide chain release factor 2; Validated; Region: prfB; PRK00578
157239003718	This domain is found in peptide chain release factors; Region: PCRF; smart00937
157239003719	RF-1 domain; Region: RF-1; pfam00472
157239003720	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
157239003721	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
157239003722	dimer interface [polypeptide binding]; other site
157239003723	putative anticodon binding site; other site
157239003724	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
157239003725	motif 1; other site
157239003726	active site
157239003727	motif 2; other site
157239003728	motif 3; other site
157239003729	malate dehydrogenase; Provisional; Region: PRK05086
157239003730	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
157239003731	NAD binding site [chemical binding]; other site
157239003732	dimerization interface [polypeptide binding]; other site
157239003733	Substrate binding site [chemical binding]; other site
157239003734	arginine repressor; Provisional; Region: PRK05066
157239003735	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
157239003736	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
157239003737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
157239003738	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
157239003739	NAD(P) binding site [chemical binding]; other site
157239003740	active site
157239003741	amidophosphoribosyltransferase; Provisional; Region: PRK09246
157239003742	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
157239003743	active site
157239003744	tetramer interface [polypeptide binding]; other site
157239003745	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239003746	active site
157239003747	Colicin V production protein; Region: Colicin_V; cl00567
157239003748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3092
157239003749	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
157239003750	phosphate acetyltransferase; Reviewed; Region: PRK05632
157239003751	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
157239003752	DRTGG domain; Region: DRTGG; pfam07085
157239003753	phosphate acetyltransferase; Region: pta; TIGR00651
157239003754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
157239003755	hypothetical protein; Provisional; Region: PRK04946
157239003756	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805
157239003757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239003758	S-adenosylmethionine binding site [chemical binding]; other site
157239003759	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
157239003760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
157239003761	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
157239003762	substrate binding site [chemical binding]; other site
157239003763	dimerization interface [polypeptide binding]; other site
157239003764	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
157239003765	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
157239003766	RNA binding surface [nucleotide binding]; other site
157239003767	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
157239003768	probable active site [active]
157239003769	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
157239003770	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
157239003771	CoA binding domain; Region: CoA_binding; pfam02629
157239003772	CoA-ligase; Region: Ligase_CoA; pfam00549
157239003773	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
157239003774	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
157239003775	CoA-ligase; Region: Ligase_CoA; pfam00549
157239003776	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
157239003777	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
157239003778	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
157239003779	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
157239003780	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
157239003781	dimerization interface [polypeptide binding]; other site
157239003782	substrate binding pocket [chemical binding]; other site
157239003783	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
157239003784	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
157239003785	homodimer interface [polypeptide binding]; other site
157239003786	substrate-cofactor binding pocket; other site
157239003787	catalytic residue [active]
157239003788	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
157239003789	Ligand Binding Site [chemical binding]; other site
157239003790	6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039
157239003791	active site
157239003792	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
157239003793	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
157239003794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239003795	FeS/SAM binding site; other site
157239003796	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
157239003797	Part of AAA domain; Region: AAA_19; pfam13245
157239003798	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
157239003799	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
157239003800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003801	dimer interface [polypeptide binding]; other site
157239003802	conserved gate region; other site
157239003803	putative PBP binding loops; other site
157239003804	ABC-ATPase subunit interface; other site
157239003805	dipeptide transporter; Provisional; Region: PRK10913
157239003806	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
157239003807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003808	dimer interface [polypeptide binding]; other site
157239003809	conserved gate region; other site
157239003810	putative PBP binding loops; other site
157239003811	ABC-ATPase subunit interface; other site
157239003812	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
157239003813	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
157239003814	Walker A/P-loop; other site
157239003815	ATP binding site [chemical binding]; other site
157239003816	Q-loop/lid; other site
157239003817	ABC transporter signature motif; other site
157239003818	Walker B; other site
157239003819	D-loop; other site
157239003820	H-loop/switch region; other site
157239003821	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
157239003822	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
157239003823	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
157239003824	Walker A/P-loop; other site
157239003825	ATP binding site [chemical binding]; other site
157239003826	Q-loop/lid; other site
157239003827	ABC transporter signature motif; other site
157239003828	Walker B; other site
157239003829	D-loop; other site
157239003830	H-loop/switch region; other site
157239003831	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
157239003832	DNA ligase; Provisional; Region: PRK09125
157239003833	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
157239003834	DNA binding site [nucleotide binding]
157239003835	active site
157239003836	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
157239003837	DNA binding site [nucleotide binding]
157239003838	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
157239003839	dimer interface [polypeptide binding]; other site
157239003840	active site
157239003841	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
157239003842	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239003843	Walker A/P-loop; other site
157239003844	ATP binding site [chemical binding]; other site
157239003845	Q-loop/lid; other site
157239003846	ABC transporter signature motif; other site
157239003847	Walker B; other site
157239003848	D-loop; other site
157239003849	H-loop/switch region; other site
157239003850	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
157239003851	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
157239003852	substrate binding pocket [chemical binding]; other site
157239003853	membrane-bound complex binding site; other site
157239003854	hinge residues; other site
157239003855	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
157239003856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003857	dimer interface [polypeptide binding]; other site
157239003858	conserved gate region; other site
157239003859	putative PBP binding loops; other site
157239003860	ABC-ATPase subunit interface; other site
157239003861	arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122
157239003862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239003863	dimer interface [polypeptide binding]; other site
157239003864	conserved gate region; other site
157239003865	putative PBP binding loops; other site
157239003866	ABC-ATPase subunit interface; other site
157239003867	YadA-like C-terminal region; Region: YadA_anchor; pfam03895
157239003868	Opacity family porin protein; Region: Opacity; pfam02462
157239003869	hypothetical protein; Provisional; Region: PRK04860
157239003870	S-adenosylmethionine synthetase; Validated; Region: PRK05250
157239003871	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
157239003872	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
157239003873	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
157239003874	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
157239003875	Glutamine amidotransferase class-I; Region: GATase; pfam00117
157239003876	glutamine binding [chemical binding]; other site
157239003877	catalytic triad [active]
157239003878	para-aminobenzoate synthase component I; Validated; Region: PRK07093
157239003879	hypothetical protein; Provisional; Region: PRK07101
157239003880	substrate-cofactor binding pocket; other site
157239003881	hypothetical protein; Provisional; Region: PRK05423
157239003882	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
157239003883	homodimer interface [polypeptide binding]; other site
157239003884	substrate-cofactor binding pocket; other site
157239003885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239003886	catalytic residue [active]
157239003887	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
157239003888	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
157239003889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239003890	homodimer interface [polypeptide binding]; other site
157239003891	catalytic residue [active]
157239003892	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
157239003893	putative GSH binding site [chemical binding]; other site
157239003894	catalytic residues [active]
157239003895	outer membrane protein A; Reviewed; Region: PRK10808
157239003896	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
157239003897	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
157239003898	ligand binding site [chemical binding]; other site
157239003899	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
157239003900	FAD binding domain; Region: FAD_binding_4; pfam01565
157239003901	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
157239003902	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
157239003903	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
157239003904	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
157239003905	CoenzymeA binding site [chemical binding]; other site
157239003906	subunit interaction site [polypeptide binding]; other site
157239003907	PHB binding site; other site
157239003908	ferrochelatase; Region: hemH; TIGR00109
157239003909	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
157239003910	C-terminal domain interface [polypeptide binding]; other site
157239003911	active site
157239003912	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
157239003913	active site
157239003914	N-terminal domain interface [polypeptide binding]; other site
157239003915	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
157239003916	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
157239003917	Tetratricopeptide repeat; Region: TPR_20; pfam14561
157239003918	thioredoxin reductase; Provisional; Region: PRK10262
157239003919	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
157239003920	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
157239003921	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
157239003922	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
157239003923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239003924	Walker A/P-loop; other site
157239003925	ATP binding site [chemical binding]; other site
157239003926	Q-loop/lid; other site
157239003927	ABC transporter signature motif; other site
157239003928	Walker B; other site
157239003929	D-loop; other site
157239003930	H-loop/switch region; other site
157239003931	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
157239003932	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
157239003933	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
157239003934	Walker A/P-loop; other site
157239003935	ATP binding site [chemical binding]; other site
157239003936	Q-loop/lid; other site
157239003937	ABC transporter signature motif; other site
157239003938	Walker B; other site
157239003939	D-loop; other site
157239003940	H-loop/switch region; other site
157239003941	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
157239003942	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239003943	FeS/SAM binding site; other site
157239003944	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
157239003945	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239003946	active site
157239003947	Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356
157239003948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028
157239003949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
157239003950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
157239003951	OstA-like protein; Region: OstA; cl00844
157239003952	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
157239003953	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
157239003954	Walker A/P-loop; other site
157239003955	ATP binding site [chemical binding]; other site
157239003956	Q-loop/lid; other site
157239003957	ABC transporter signature motif; other site
157239003958	Walker B; other site
157239003959	D-loop; other site
157239003960	H-loop/switch region; other site
157239003961	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
157239003962	active site
157239003963	phosphorylation site [posttranslational modification]
157239003964	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
157239003965	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
157239003966	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
157239003967	Prephenate dehydratase; Region: PDT; pfam00800
157239003968	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
157239003969	putative L-Phe binding site [chemical binding]; other site
157239003970	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
157239003971	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
157239003972	cell division protein FtsZ; Validated; Region: PRK09330
157239003973	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
157239003974	nucleotide binding site [chemical binding]; other site
157239003975	SulA interaction site; other site
157239003976	cell division protein FtsA; Region: ftsA; TIGR01174
157239003977	Cell division protein FtsA; Region: FtsA; smart00842
157239003978	Cell division protein FtsA; Region: FtsA; pfam14450
157239003979	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
157239003980	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
157239003981	Cell division protein FtsQ; Region: FtsQ; pfam03799
157239003982	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
157239003983	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
157239003984	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
157239003985	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
157239003986	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
157239003987	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
157239003988	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
157239003989	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
157239003990	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
157239003991	active site
157239003992	homodimer interface [polypeptide binding]; other site
157239003993	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
157239003994	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
157239003995	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
157239003996	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
157239003997	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
157239003998	Mg++ binding site [ion binding]; other site
157239003999	putative catalytic motif [active]
157239004000	putative substrate binding site [chemical binding]; other site
157239004001	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
157239004002	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
157239004003	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
157239004004	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
157239004005	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
157239004006	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
157239004007	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
157239004008	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
157239004009	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
157239004010	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
157239004011	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
157239004012	Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116
157239004013	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
157239004014	mraZ protein; Region: TIGR00242
157239004015	MraZ protein; Region: MraZ; pfam02381
157239004016	MraZ protein; Region: MraZ; pfam02381
157239004017	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
157239004018	Carbon starvation protein CstA; Region: CstA; pfam02554
157239004019	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
157239004020	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
157239004021	transaldolase-like protein; Provisional; Region: PTZ00411
157239004022	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
157239004023	active site
157239004024	dimer interface [polypeptide binding]; other site
157239004025	catalytic residue [active]
157239004026	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
157239004027	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
157239004028	peptide binding site [polypeptide binding]; other site
157239004029	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
157239004030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239004031	dimer interface [polypeptide binding]; other site
157239004032	conserved gate region; other site
157239004033	putative PBP binding loops; other site
157239004034	ABC-ATPase subunit interface; other site
157239004035	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
157239004036	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
157239004037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239004038	dimer interface [polypeptide binding]; other site
157239004039	conserved gate region; other site
157239004040	putative PBP binding loops; other site
157239004041	ABC-ATPase subunit interface; other site
157239004042	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
157239004043	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
157239004044	Walker A/P-loop; other site
157239004045	ATP binding site [chemical binding]; other site
157239004046	Q-loop/lid; other site
157239004047	ABC transporter signature motif; other site
157239004048	Walker B; other site
157239004049	D-loop; other site
157239004050	H-loop/switch region; other site
157239004051	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
157239004052	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
157239004053	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
157239004054	Walker A/P-loop; other site
157239004055	ATP binding site [chemical binding]; other site
157239004056	Q-loop/lid; other site
157239004057	ABC transporter signature motif; other site
157239004058	Walker B; other site
157239004059	D-loop; other site
157239004060	H-loop/switch region; other site
157239004061	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
157239004062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
157239004063	Predicted GTPase [General function prediction only]; Region: COG0218
157239004064	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
157239004065	G1 box; other site
157239004066	GTP/Mg2+ binding site [chemical binding]; other site
157239004067	Switch I region; other site
157239004068	G2 box; other site
157239004069	G3 box; other site
157239004070	Switch II region; other site
157239004071	G4 box; other site
157239004072	G5 box; other site
157239004073	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
157239004074	intersubunit interface [polypeptide binding]; other site
157239004075	active site
157239004076	catalytic residue [active]
157239004077	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
157239004078	catalytic residues [active]
157239004079	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
157239004080	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
157239004081	NADP binding site [chemical binding]; other site
157239004082	homopentamer interface [polypeptide binding]; other site
157239004083	substrate binding site [chemical binding]; other site
157239004084	active site
157239004085	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
157239004086	N- and C-terminal domain interface [polypeptide binding]; other site
157239004087	D-xylulose kinase; Region: XylB; TIGR01312
157239004088	active site
157239004089	MgATP binding site [chemical binding]; other site
157239004090	catalytic site [active]
157239004091	metal binding site [ion binding]; metal-binding site
157239004092	xylulose binding site [chemical binding]; other site
157239004093	putative homodimer interface [polypeptide binding]; other site
157239004094	xylose isomerase; Provisional; Region: PRK05474
157239004095	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
157239004096	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
157239004097	putative ligand binding site [chemical binding]; other site
157239004098	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
157239004099	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
157239004100	Walker A/P-loop; other site
157239004101	ATP binding site [chemical binding]; other site
157239004102	Q-loop/lid; other site
157239004103	ABC transporter signature motif; other site
157239004104	Walker B; other site
157239004105	D-loop; other site
157239004106	H-loop/switch region; other site
157239004107	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
157239004108	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
157239004109	TM-ABC transporter signature motif; other site
157239004110	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
157239004111	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
157239004112	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239004113	homodimer interface [polypeptide binding]; other site
157239004114	catalytic residue [active]
157239004115	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
157239004116	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
157239004117	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
157239004118	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
157239004119	putative dimerization interface [polypeptide binding]; other site
157239004120	Transcriptional regulators [Transcription]; Region: PurR; COG1609
157239004121	putative ligand binding site [chemical binding]; other site
157239004122	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
157239004123	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
157239004124	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
157239004125	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
157239004126	putative active site [active]
157239004127	benzoate transport; Region: 2A0115; TIGR00895
157239004128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239004129	putative substrate translocation pore; other site
157239004130	cysteine synthase; Region: PLN02565
157239004131	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
157239004132	dimer interface [polypeptide binding]; other site
157239004133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239004134	catalytic residue [active]
157239004135	putative sulfate transport protein CysZ; Validated; Region: PRK04949
157239004136	cell division protein ZipA; Provisional; Region: PRK01741
157239004137	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
157239004138	FtsZ protein binding site [polypeptide binding]; other site
157239004139	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
157239004140	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
157239004141	nucleotide binding pocket [chemical binding]; other site
157239004142	K-X-D-G motif; other site
157239004143	catalytic site [active]
157239004144	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
157239004145	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
157239004146	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
157239004147	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
157239004148	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
157239004149	Dimer interface [polypeptide binding]; other site
157239004150	BRCT sequence motif; other site
157239004151	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
157239004152	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
157239004153	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
157239004154	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
157239004155	TPR motif; other site
157239004156	binding surface
157239004157	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
157239004158	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
157239004159	catalytic residues [active]
157239004160	central insert; other site
157239004161	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
157239004162	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
157239004163	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
157239004164	heme exporter protein CcmC; Region: ccmC; TIGR01191
157239004165	heme exporter protein CcmB; Region: ccmB; TIGR01190
157239004166	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
157239004167	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
157239004168	Walker A/P-loop; other site
157239004169	ATP binding site [chemical binding]; other site
157239004170	Q-loop/lid; other site
157239004171	ABC transporter signature motif; other site
157239004172	Walker B; other site
157239004173	D-loop; other site
157239004174	H-loop/switch region; other site
157239004175	superoxide dismutase; Provisional; Region: PRK10925
157239004176	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
157239004177	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
157239004178	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
157239004179	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
157239004180	Walker A/P-loop; other site
157239004181	ATP binding site [chemical binding]; other site
157239004182	Q-loop/lid; other site
157239004183	ABC transporter signature motif; other site
157239004184	Walker B; other site
157239004185	D-loop; other site
157239004186	H-loop/switch region; other site
157239004187	conserved hypothetical integral membrane protein; Region: TIGR00056
157239004188	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
157239004189	mce related protein; Region: MCE; pfam02470
157239004190	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854
157239004191	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
157239004192	anti sigma factor interaction site; other site
157239004193	regulatory phosphorylation site [posttranslational modification]; other site
157239004194	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
157239004195	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
157239004196	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
157239004197	hinge; other site
157239004198	active site
157239004199	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
157239004200	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
157239004201	substrate binding pocket [chemical binding]; other site
157239004202	membrane-bound complex binding site; other site
157239004203	hinge residues; other site
157239004204	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
157239004205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239004206	dimer interface [polypeptide binding]; other site
157239004207	conserved gate region; other site
157239004208	putative PBP binding loops; other site
157239004209	ABC-ATPase subunit interface; other site
157239004210	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
157239004211	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
157239004212	Walker A/P-loop; other site
157239004213	ATP binding site [chemical binding]; other site
157239004214	Q-loop/lid; other site
157239004215	ABC transporter signature motif; other site
157239004216	Walker B; other site
157239004217	D-loop; other site
157239004218	H-loop/switch region; other site
157239004219	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
157239004220	CTP synthetase; Validated; Region: pyrG; PRK05380
157239004221	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
157239004222	Catalytic site [active]
157239004223	active site
157239004224	UTP binding site [chemical binding]; other site
157239004225	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
157239004226	active site
157239004227	putative oxyanion hole; other site
157239004228	catalytic triad [active]
157239004229	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
157239004230	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
157239004231	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
157239004232	Predicted membrane protein [Function unknown]; Region: COG2707
157239004233	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
157239004234	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
157239004235	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239004236	ATP binding site [chemical binding]; other site
157239004237	putative Mg++ binding site [ion binding]; other site
157239004238	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239004239	nucleotide binding region [chemical binding]; other site
157239004240	ATP-binding site [chemical binding]; other site
157239004241	Helicase associated domain (HA2); Region: HA2; pfam04408
157239004242	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
157239004243	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
157239004244	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
157239004245	Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926
157239004246	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914
157239004247	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
157239004248	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
157239004249	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048
157239004250	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
157239004251	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
157239004252	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
157239004253	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
157239004254	putative nucleotide binding site [chemical binding]; other site
157239004255	uridine monophosphate binding site [chemical binding]; other site
157239004256	homohexameric interface [polypeptide binding]; other site
157239004257	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
157239004258	Sulfatase; Region: Sulfatase; pfam00884
157239004259	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
157239004260	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
157239004261	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
157239004262	active site
157239004263	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
157239004264	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
157239004265	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
157239004266	RNA/DNA hybrid binding site [nucleotide binding]; other site
157239004267	active site
157239004268	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
157239004269	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
157239004270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
157239004271	DNA methylase; Region: N6_N4_Mtase; pfam01555
157239004272	DEAD-like helicases superfamily; Region: DEXDc; smart00487
157239004273	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239004274	ATP binding site [chemical binding]; other site
157239004275	putative Mg++ binding site [ion binding]; other site
157239004276	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
157239004277	Cupin; Region: Cupin_6; pfam12852
157239004278	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
157239004279	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
157239004280	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
157239004281	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
157239004282	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
157239004283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239004284	Walker A/P-loop; other site
157239004285	ATP binding site [chemical binding]; other site
157239004286	Q-loop/lid; other site
157239004287	ABC transporter signature motif; other site
157239004288	Walker B; other site
157239004289	D-loop; other site
157239004290	H-loop/switch region; other site
157239004291	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
157239004292	metal-binding site [ion binding]
157239004293	MerT mercuric transport protein; Region: MerT; cl03578
157239004294	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
157239004295	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
157239004296	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
157239004297	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
157239004298	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
157239004299	putative [Fe4-S4] binding site [ion binding]; other site
157239004300	putative molybdopterin cofactor binding site [chemical binding]; other site
157239004301	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
157239004302	putative molybdopterin cofactor binding site; other site
157239004303	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
157239004304	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
157239004305	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
157239004306	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
157239004307	ferredoxin-type protein; Provisional; Region: PRK10194
157239004308	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
157239004309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
157239004310	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
157239004311	AAA domain; Region: AAA_14; pfam13173
157239004312	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
157239004313	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
157239004314	putative active site [active]
157239004315	Glutamine amidotransferases class-II; Region: GATase_2; pfam00310
157239004316	putative dimer interface [polypeptide binding]; other site
157239004317	YGGT family; Region: YGGT; pfam02325
157239004318	Predicted integral membrane protein [Function unknown]; Region: COG0762
157239004319	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
157239004320	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
157239004321	Cl binding site [ion binding]; other site
157239004322	oligomer interface [polypeptide binding]; other site
157239004323	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
157239004324	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
157239004325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
157239004326	motif II; other site
157239004327	transketolase; Reviewed; Region: PRK12753
157239004328	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
157239004329	TPP-binding site [chemical binding]; other site
157239004330	dimer interface [polypeptide binding]; other site
157239004331	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
157239004332	PYR/PP interface [polypeptide binding]; other site
157239004333	dimer interface [polypeptide binding]; other site
157239004334	TPP binding site [chemical binding]; other site
157239004335	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
157239004336	biotin synthase; Region: bioB; TIGR00433
157239004337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239004338	FeS/SAM binding site; other site
157239004339	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
157239004340	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
157239004341	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239004342	Walker A/P-loop; other site
157239004343	ATP binding site [chemical binding]; other site
157239004344	Q-loop/lid; other site
157239004345	ABC transporter signature motif; other site
157239004346	Walker B; other site
157239004347	D-loop; other site
157239004348	H-loop/switch region; other site
157239004349	thiamine ABC transporter, permease protein; Region: thiP; TIGR01253
157239004350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239004351	dimer interface [polypeptide binding]; other site
157239004352	conserved gate region; other site
157239004353	putative PBP binding loops; other site
157239004354	ABC-ATPase subunit interface; other site
157239004355	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239004356	dimer interface [polypeptide binding]; other site
157239004357	conserved gate region; other site
157239004358	putative PBP binding loops; other site
157239004359	ABC-ATPase subunit interface; other site
157239004360	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
157239004361	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
157239004362	amphipathic channel; other site
157239004363	Asn-Pro-Ala signature motifs; other site
157239004364	GntP family permease; Region: GntP_permease; pfam02447
157239004365	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
157239004366	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
157239004367	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
157239004368	putative NAD(P) binding site [chemical binding]; other site
157239004369	active site
157239004370	putative substrate binding site [chemical binding]; other site
157239004371	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
157239004372	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
157239004373	putative aldolase; Validated; Region: PRK08130
157239004374	intersubunit interface [polypeptide binding]; other site
157239004375	active site
157239004376	Zn2+ binding site [ion binding]; other site
157239004377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
157239004378	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
157239004379	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
157239004380	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
157239004381	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
157239004382	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
157239004383	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
157239004384	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
157239004385	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
157239004386	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
157239004387	Fe-S cluster binding site [ion binding]; other site
157239004388	substrate binding site [chemical binding]; other site
157239004389	catalytic site [active]
157239004390	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
157239004391	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
157239004392	Acyltransferase family; Region: Acyl_transf_3; cl19154
157239004393	Sulfatase; Region: Sulfatase; pfam00884
157239004394	periplasmic folding chaperone; Provisional; Region: PRK10788
157239004395	SurA N-terminal domain; Region: SurA_N_3; cl07813
157239004396	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
157239004397	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
157239004398	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
157239004399	trmE is a tRNA modification GTPase; Region: trmE; cd04164
157239004400	G1 box; other site
157239004401	GTP/Mg2+ binding site [chemical binding]; other site
157239004402	Switch I region; other site
157239004403	G2 box; other site
157239004404	Switch II region; other site
157239004405	G3 box; other site
157239004406	G4 box; other site
157239004407	G5 box; other site
157239004408	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
157239004409	membrane protein insertase; Provisional; Region: PRK01318
157239004410	YidC periplasmic domain; Region: YidC_periplas; pfam14849
157239004411	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
157239004412	hypothetical protein; Validated; Region: PRK00041
157239004413	ribonuclease P; Reviewed; Region: rnpA; PRK01732
157239004414	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
157239004415	Protein of unknown function (DUF560); Region: DUF560; pfam04575
157239004416	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
157239004417	TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776
157239004418	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
157239004419	N-terminal plug; other site
157239004420	ligand-binding site [chemical binding]; other site
157239004421	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
157239004422	DnaA N-terminal domain; Region: DnaA_N; pfam11638
157239004423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239004424	Walker A motif; other site
157239004425	ATP binding site [chemical binding]; other site
157239004426	Walker B motif; other site
157239004427	arginine finger; other site
157239004428	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
157239004429	DnaA box-binding interface [nucleotide binding]; other site
157239004430	DNA polymerase III subunit beta; Validated; Region: PRK05643
157239004431	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
157239004432	putative DNA binding surface [nucleotide binding]; other site
157239004433	dimer interface [polypeptide binding]; other site
157239004434	beta-clamp/clamp loader binding surface; other site
157239004435	beta-clamp/translesion DNA polymerase binding surface; other site
157239004436	recF protein; Region: recf; TIGR00611
157239004437	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239004438	Walker A/P-loop; other site
157239004439	ATP binding site [chemical binding]; other site
157239004440	Q-loop/lid; other site
157239004441	ABC transporter signature motif; other site
157239004442	Walker B; other site
157239004443	D-loop; other site
157239004444	H-loop/switch region; other site
157239004445	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
157239004446	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
157239004447	Paralemmin; Region: Paralemmin; pfam03285
157239004448	Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466
157239004449	Autotransporter beta-domain; Region: Autotransporter; pfam03797
157239004450	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
157239004451	substrate binding site [chemical binding]; other site
157239004452	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
157239004453	substrate binding site [chemical binding]; other site
157239004454	ligand binding site [chemical binding]; other site
157239004455	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
157239004456	2-isopropylmalate synthase; Validated; Region: PRK00915
157239004457	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
157239004458	active site
157239004459	catalytic residues [active]
157239004460	metal binding site [ion binding]; metal-binding site
157239004461	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
157239004462	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
157239004463	DNA protecting protein DprA; Region: dprA; TIGR00732
157239004464	hypothetical protein; Validated; Region: PRK02101
157239004465	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
157239004466	active site
157239004467	ADP/pyrophosphate binding site [chemical binding]; other site
157239004468	dimerization interface [polypeptide binding]; other site
157239004469	allosteric effector site; other site
157239004470	fructose-1,6-bisphosphate binding site; other site
157239004471	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
157239004472	SmpB-tmRNA interface; other site
157239004473	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
157239004474	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
157239004475	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
157239004476	FMN binding site [chemical binding]; other site
157239004477	active site
157239004478	catalytic residues [active]
157239004479	substrate binding site [chemical binding]; other site
157239004480	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
157239004481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239004482	S-adenosylmethionine binding site [chemical binding]; other site
157239004483	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
157239004484	EamA-like transporter family; Region: EamA; pfam00892
157239004485	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
157239004486	EamA-like transporter family; Region: EamA; pfam00892
157239004487	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
157239004488	Na binding site [ion binding]; other site
157239004489	Predicted membrane protein [Function unknown]; Region: COG3924
157239004490	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
157239004491	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
157239004492	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
157239004493	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
157239004494	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
157239004495	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
157239004496	carboxyltransferase (CT) interaction site; other site
157239004497	biotinylation site [posttranslational modification]; other site
157239004498	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
157239004499	trimer interface [polypeptide binding]; other site
157239004500	active site
157239004501	dimer interface [polypeptide binding]; other site
157239004502	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
157239004503	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
157239004504	active site
157239004505	dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
157239004506	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
157239004507	substrate binding site [chemical binding]; other site
157239004508	oxyanion hole (OAH) forming residues; other site
157239004509	trimer interface [polypeptide binding]; other site
157239004510	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
157239004511	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
157239004512	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
157239004513	Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667
157239004514	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
157239004515	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
157239004516	active site
157239004517	Riboflavin kinase; Region: Flavokinase; smart00904
157239004518	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
157239004519	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
157239004520	active site
157239004521	HIGH motif; other site
157239004522	nucleotide binding site [chemical binding]; other site
157239004523	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
157239004524	active site
157239004525	KMSKS motif; other site
157239004526	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
157239004527	tRNA binding surface [nucleotide binding]; other site
157239004528	anticodon binding site; other site
157239004529	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
157239004530	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
157239004531	nucleotide binding site/active site [active]
157239004532	HIT family signature motif; other site
157239004533	catalytic residue [active]
157239004534	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
157239004535	putative dimer interface [polypeptide binding]; other site
157239004536	beta-hexosaminidase; Provisional; Region: PRK05337
157239004537	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
157239004538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239004539	S-adenosylmethionine binding site [chemical binding]; other site
157239004540	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
157239004541	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
157239004542	ligand binding site [chemical binding]; other site
157239004543	flexible hinge region; other site
157239004544	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
157239004545	putative switch regulator; other site
157239004546	non-specific DNA interactions [nucleotide binding]; other site
157239004547	DNA binding site [nucleotide binding]
157239004548	sequence specific DNA binding site [nucleotide binding]; other site
157239004549	putative cAMP binding site [chemical binding]; other site
157239004550	hypothetical protein; Provisional; Region: PRK04966
157239004551	division inhibitor protein; Provisional; Region: slmA; PRK09480
157239004552	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
157239004553	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
157239004554	trimer interface [polypeptide binding]; other site
157239004555	active site
157239004556	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
157239004557	Flavoprotein; Region: Flavoprotein; cl19190
157239004558	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
157239004559	hypothetical protein; Reviewed; Region: PRK00024
157239004560	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
157239004561	MPN+ (JAMM) motif; other site
157239004562	Zinc-binding site [ion binding]; other site
157239004563	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
157239004564	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
157239004565	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
157239004566	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
157239004567	inhibitor-cofactor binding pocket; inhibition site
157239004568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239004569	catalytic residue [active]
157239004570	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
157239004571	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
157239004572	oligomeric interface; other site
157239004573	putative active site [active]
157239004574	homodimer interface [polypeptide binding]; other site
157239004575	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
157239004576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239004577	catalytic residue [active]
157239004578	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
157239004579	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
157239004580	DNA binding site [nucleotide binding]
157239004581	catalytic residue [active]
157239004582	H2TH interface [polypeptide binding]; other site
157239004583	putative catalytic residues [active]
157239004584	turnover-facilitating residue; other site
157239004585	intercalation triad [nucleotide binding]; other site
157239004586	8OG recognition residue [nucleotide binding]; other site
157239004587	putative reading head residues; other site
157239004588	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
157239004589	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
157239004590	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
157239004591	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
157239004592	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
157239004593	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
157239004594	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
157239004595	catalytic motif [active]
157239004596	Zn binding site [ion binding]; other site
157239004597	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
157239004598	transcriptional regulator NrdR; Region: TIGR00244
157239004599	ATP cone domain; Region: ATP-cone; pfam03477
157239004600	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
157239004601	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914
157239004602	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
157239004603	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
157239004604	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
157239004605	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
157239004606	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
157239004607	active site
157239004608	dimerization interface [polypeptide binding]; other site
157239004609	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
157239004610	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
157239004611	catalytic residues [active]
157239004612	central insert; other site
157239004613	cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147
157239004614	TPR repeat; Region: TPR_11; pfam13414
157239004615	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
157239004616	binding surface
157239004617	TPR motif; other site
157239004618	Predicted flavoproteins [General function prediction only]; Region: COG2081
157239004619	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
157239004620	enolase; Provisional; Region: eno; PRK00077
157239004621	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
157239004622	dimer interface [polypeptide binding]; other site
157239004623	metal binding site [ion binding]; metal-binding site
157239004624	substrate binding pocket [chemical binding]; other site
157239004625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4316
157239004626	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
157239004627	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
157239004628	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
157239004629	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
157239004630	tetramer interface [polypeptide binding]; other site
157239004631	heme binding pocket [chemical binding]; other site
157239004632	NADPH binding site [chemical binding]; other site
157239004633	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
157239004634	dimer interface [polypeptide binding]; other site
157239004635	motif 1; other site
157239004636	active site
157239004637	motif 2; other site
157239004638	motif 3; other site
157239004639	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
157239004640	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
157239004641	putative active site [active]
157239004642	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
157239004643	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
157239004644	tRNA binding surface [nucleotide binding]; other site
157239004645	anticodon binding site; other site
157239004646	DALR anticodon binding domain; Region: DALR_1; pfam05746
157239004647	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
157239004648	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
157239004649	Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840
157239004650	Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980
157239004651	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
157239004652	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
157239004653	active site
157239004654	HIGH motif; other site
157239004655	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
157239004656	KMSKS motif; other site
157239004657	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
157239004658	tRNA binding surface [nucleotide binding]; other site
157239004659	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
157239004660	active site
157239004661	dimer interface [polypeptide binding]; other site
157239004662	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
157239004663	zinc metallopeptidase RseP; Provisional; Region: PRK10779
157239004664	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
157239004665	active site
157239004666	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
157239004667	protein binding site [polypeptide binding]; other site
157239004668	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
157239004669	protein binding site [polypeptide binding]; other site
157239004670	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
157239004671	putative substrate binding region [chemical binding]; other site
157239004672	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
157239004673	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
157239004674	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
157239004675	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
157239004676	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
157239004677	Surface antigen; Region: Bac_surface_Ag; pfam01103
157239004678	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
157239004679	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
157239004680	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
157239004681	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
157239004682	trimer interface [polypeptide binding]; other site
157239004683	active site
157239004684	UDP-GlcNAc binding site [chemical binding]; other site
157239004685	lipid binding site [chemical binding]; lipid-binding site
157239004686	elongation factor Ts; Provisional; Region: tsf; PRK09377
157239004687	UBA/TS-N domain; Region: UBA; pfam00627
157239004688	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
157239004689	rRNA interaction site [nucleotide binding]; other site
157239004690	S8 interaction site; other site
157239004691	putative laminin-1 binding site; other site
157239004692	Methyltransferase domain; Region: Methyltransf_31; pfam13847
157239004693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239004694	S-adenosylmethionine binding site [chemical binding]; other site
157239004695	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
157239004696	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
157239004697	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238
157239004698	TrkA-N domain; Region: TrkA_N; pfam02254
157239004699	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
157239004700	active site
157239004701	8-oxo-dGMP binding site [chemical binding]; other site
157239004702	nudix motif; other site
157239004703	metal binding site [ion binding]; metal-binding site
157239004704	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
157239004705	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
157239004706	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
157239004707	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239004708	nucleotide binding region [chemical binding]; other site
157239004709	ATP-binding site [chemical binding]; other site
157239004710	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
157239004711	SEC-C motif; Region: SEC-C; pfam02810
157239004712	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
157239004713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701
157239004714	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
157239004715	nucleoside/Zn binding site; other site
157239004716	dimer interface [polypeptide binding]; other site
157239004717	catalytic motif [active]
157239004718	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
157239004719	dimerization interface [polypeptide binding]; other site
157239004720	active site
157239004721	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
157239004722	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
157239004723	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
157239004724	putative active site [active]
157239004725	Ap4A binding site [chemical binding]; other site
157239004726	nudix motif; other site
157239004727	putative metal binding site [ion binding]; other site
157239004728	gamma-glutamyl kinase; Provisional; Region: PRK05429
157239004729	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
157239004730	nucleotide binding site [chemical binding]; other site
157239004731	homotetrameric interface [polypeptide binding]; other site
157239004732	putative phosphate binding site [ion binding]; other site
157239004733	putative allosteric binding site; other site
157239004734	PUA domain; Region: PUA; pfam01472
157239004735	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
157239004736	folate binding site [chemical binding]; other site
157239004737	NADP+ binding site [chemical binding]; other site
157239004738	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
157239004739	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
157239004740	M domain of GW182; Region: M_domain; pfam12938
157239004741	HlyD family secretion protein; Region: HlyD_3; pfam13437
157239004742	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
157239004743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239004744	putative substrate translocation pore; other site
157239004745	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
157239004746	Sporulation related domain; Region: SPOR; pfam05036
157239004747	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
157239004748	MMPL family; Region: MMPL; cl14618
157239004749	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
157239004750	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
157239004751	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
157239004752	HlyD family secretion protein; Region: HlyD_3; pfam13437
157239004753	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
157239004754	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
157239004755	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
157239004756	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
157239004757	ATP binding site [chemical binding]; other site
157239004758	Mg++ binding site [ion binding]; other site
157239004759	motif III; other site
157239004760	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239004761	nucleotide binding region [chemical binding]; other site
157239004762	ATP-binding site [chemical binding]; other site
157239004763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3024
157239004764	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
157239004765	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
157239004766	CoA-binding site [chemical binding]; other site
157239004767	ATP-binding [chemical binding]; other site
157239004768	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
157239004769	dimer interface [polypeptide binding]; other site
157239004770	active site
157239004771	glycine-pyridoxal phosphate binding site [chemical binding]; other site
157239004772	folate binding site [chemical binding]; other site
157239004773	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
157239004774	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
157239004775	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
157239004776	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
157239004777	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
157239004778	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
157239004779	purine monophosphate binding site [chemical binding]; other site
157239004780	dimer interface [polypeptide binding]; other site
157239004781	putative catalytic residues [active]
157239004782	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
157239004783	Predicted membrane protein [Function unknown]; Region: COG2259
157239004784	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
157239004785	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
157239004786	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
157239004787	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
157239004788	DsbD alpha interface [polypeptide binding]; other site
157239004789	catalytic residues [active]
157239004790	two-component response regulator; Provisional; Region: PRK11173
157239004791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
157239004792	active site
157239004793	phosphorylation site [posttranslational modification]
157239004794	intermolecular recognition site; other site
157239004795	dimerization interface [polypeptide binding]; other site
157239004796	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
157239004797	DNA binding site [nucleotide binding]
157239004798	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
157239004799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
157239004800	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
157239004801	substrate binding pocket [chemical binding]; other site
157239004802	chain length determination region; other site
157239004803	substrate-Mg2+ binding site; other site
157239004804	catalytic residues [active]
157239004805	aspartate-rich region 1; other site
157239004806	active site lid residues [active]
157239004807	aspartate-rich region 2; other site
157239004808	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
157239004809	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
157239004810	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
157239004811	EamA-like transporter family; Region: EamA; pfam00892
157239004812	EamA-like transporter family; Region: EamA; pfam00892
157239004813	GTPase CgtA; Reviewed; Region: obgE; PRK12298
157239004814	GTP1/OBG; Region: GTP1_OBG; pfam01018
157239004815	Obg GTPase; Region: Obg; cd01898
157239004816	G1 box; other site
157239004817	GTP/Mg2+ binding site [chemical binding]; other site
157239004818	Switch I region; other site
157239004819	G2 box; other site
157239004820	G3 box; other site
157239004821	Switch II region; other site
157239004822	G4 box; other site
157239004823	G5 box; other site
157239004824	Nucleoside diphosphate kinase; Region: NDK; pfam00334
157239004825	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
157239004826	active site
157239004827	multimer interface [polypeptide binding]; other site
157239004828	aminopeptidase B; Provisional; Region: PRK05015
157239004829	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
157239004830	interface (dimer of trimers) [polypeptide binding]; other site
157239004831	Substrate-binding/catalytic site; other site
157239004832	Zn-binding sites [ion binding]; other site
157239004833	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
157239004834	O-Antigen ligase; Region: Wzy_C; pfam04932
157239004835	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
157239004836	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
157239004837	NAD binding site [chemical binding]; other site
157239004838	substrate binding site [chemical binding]; other site
157239004839	homodimer interface [polypeptide binding]; other site
157239004840	active site
157239004841	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
157239004842	CoA binding domain; Region: CoA_binding; cl17356
157239004843	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
157239004844	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
157239004845	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440
157239004846	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
157239004847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
157239004848	active site
157239004849	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
157239004850	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
157239004851	active site
157239004852	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
157239004853	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
157239004854	glutamine synthetase; Provisional; Region: glnA; PRK09469
157239004855	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
157239004856	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
157239004857	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
157239004858	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
157239004859	G1 box; other site
157239004860	putative GEF interaction site [polypeptide binding]; other site
157239004861	GTP/Mg2+ binding site [chemical binding]; other site
157239004862	Switch I region; other site
157239004863	G2 box; other site
157239004864	G3 box; other site
157239004865	Switch II region; other site
157239004866	G4 box; other site
157239004867	G5 box; other site
157239004868	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
157239004869	Elongation Factor G, domain II; Region: EFG_II; pfam14492
157239004870	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
157239004871	Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
157239004872	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
157239004873	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
157239004874	hypothetical protein; Provisional; Region: PRK11212
157239004875	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
157239004876	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
157239004877	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
157239004878	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
157239004879	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
157239004880	DNA binding site [nucleotide binding]
157239004881	catalytic residue [active]
157239004882	H2TH interface [polypeptide binding]; other site
157239004883	putative catalytic residues [active]
157239004884	turnover-facilitating residue; other site
157239004885	intercalation triad [nucleotide binding]; other site
157239004886	8OG recognition residue [nucleotide binding]; other site
157239004887	putative reading head residues; other site
157239004888	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
157239004889	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
157239004890	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
157239004891	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
157239004892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239004893	Walker A/P-loop; other site
157239004894	ATP binding site [chemical binding]; other site
157239004895	Q-loop/lid; other site
157239004896	ABC transporter signature motif; other site
157239004897	Walker B; other site
157239004898	D-loop; other site
157239004899	H-loop/switch region; other site
157239004900	YadA-like C-terminal region; Region: YadA_anchor; pfam03895
157239004901	exoribonuclease R; Provisional; Region: PRK11642
157239004902	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
157239004903	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
157239004904	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
157239004905	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
157239004906	RNA binding site [nucleotide binding]; other site
157239004907	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
157239004908	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
157239004909	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
157239004910	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
157239004911	Clp amino terminal domain; Region: Clp_N; pfam02861
157239004912	Clp amino terminal domain; Region: Clp_N; pfam02861
157239004913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239004914	Walker A motif; other site
157239004915	ATP binding site [chemical binding]; other site
157239004916	Walker B motif; other site
157239004917	arginine finger; other site
157239004918	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239004919	Walker A motif; other site
157239004920	ATP binding site [chemical binding]; other site
157239004921	Walker B motif; other site
157239004922	arginine finger; other site
157239004923	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
157239004924	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
157239004925	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
157239004926	DNA polymerase I; Provisional; Region: PRK05755
157239004927	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
157239004928	active site
157239004929	metal binding site 1 [ion binding]; metal-binding site
157239004930	putative 5' ssDNA interaction site; other site
157239004931	metal binding site 3; metal-binding site
157239004932	metal binding site 2 [ion binding]; metal-binding site
157239004933	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
157239004934	putative DNA binding site [nucleotide binding]; other site
157239004935	putative metal binding site [ion binding]; other site
157239004936	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
157239004937	active site
157239004938	catalytic site [active]
157239004939	substrate binding site [chemical binding]; other site
157239004940	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
157239004941	active site
157239004942	DNA binding site [nucleotide binding]
157239004943	catalytic site [active]
157239004944	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
157239004945	heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109
157239004946	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
157239004947	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
157239004948	antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109
157239004949	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
157239004950	peptide binding site [polypeptide binding]; other site
157239004951	putative transporter; Provisional; Region: PRK10504
157239004952	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239004953	putative substrate translocation pore; other site
157239004954	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
157239004955	Walker A motif; other site
157239004956	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
157239004957	Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445
157239004958	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
157239004959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239004960	S-adenosylmethionine binding site [chemical binding]; other site
157239004961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3085
157239004962	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
157239004963	catalytic residues [active]
157239004964	hinge region; other site
157239004965	alpha helical domain; other site
157239004966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084
157239004967	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
157239004968	GTP binding site; other site
157239004969	hypothetical protein; Validated; Region: PRK06886
157239004970	Amidohydrolase; Region: Amidohydro_4; pfam13147
157239004971	active site
157239004972	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
157239004973	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
157239004974	Sulfatase; Region: Sulfatase; cl19157
157239004975	hypothetical protein; Provisional; Region: PRK13689
157239004976	Nucleoid-associated protein [General function prediction only]; Region: COG3081
157239004977	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
157239004978	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
157239004979	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
157239004980	active site
157239004981	phosphorylation site [posttranslational modification]
157239004982	intermolecular recognition site; other site
157239004983	dimerization interface [polypeptide binding]; other site
157239004984	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
157239004985	DNA binding site [nucleotide binding]
157239004986	poxB regulator PoxA; Provisional; Region: PRK09350
157239004987	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
157239004988	motif 1; other site
157239004989	dimer interface [polypeptide binding]; other site
157239004990	active site
157239004991	motif 2; other site
157239004992	motif 3; other site
157239004993	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
157239004994	L-aspartate oxidase; Provisional; Region: PRK06175
157239004995	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
157239004996	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
157239004997	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
157239004998	catalytic loop [active]
157239004999	iron binding site [ion binding]; other site
157239005000	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
157239005001	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
157239005002	D-subunit interface [polypeptide binding]; other site
157239005003	Iron-sulfur protein interface; other site
157239005004	proximal quinone binding site [chemical binding]; other site
157239005005	distal quinone binding site [chemical binding]; other site
157239005006	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
157239005007	Iron-sulfur protein interface; other site
157239005008	proximal quinone binding site [chemical binding]; other site
157239005009	C-subunit interface; other site
157239005010	distal quinone binding site; other site
157239005011	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
157239005012	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
157239005013	Trp operon repressor; Provisional; Region: PRK01381
157239005014	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
157239005015	Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718
157239005016	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
157239005017	N-acetyl-D-glucosamine binding site [chemical binding]; other site
157239005018	catalytic residue [active]
157239005019	YciI-like protein; Reviewed; Region: PRK11370
157239005020	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
157239005021	intracellular septation protein A; Reviewed; Region: PRK00259
157239005022	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
157239005023	TM-ABC transporter signature motif; other site
157239005024	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
157239005025	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
157239005026	Walker A/P-loop; other site
157239005027	ATP binding site [chemical binding]; other site
157239005028	Q-loop/lid; other site
157239005029	ABC transporter signature motif; other site
157239005030	Walker B; other site
157239005031	D-loop; other site
157239005032	H-loop/switch region; other site
157239005033	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
157239005034	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
157239005035	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
157239005036	ligand binding site [chemical binding]; other site
157239005037	calcium binding site [ion binding]; other site
157239005038	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
157239005039	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
157239005040	DNA binding site [nucleotide binding]
157239005041	domain linker motif; other site
157239005042	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
157239005043	dimerization interface (closed form) [polypeptide binding]; other site
157239005044	ligand binding site [chemical binding]; other site
157239005045	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
157239005046	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
157239005047	dimer interface [polypeptide binding]; other site
157239005048	active site
157239005049	galactokinase; Provisional; Region: PRK05101
157239005050	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
157239005051	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
157239005052	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
157239005053	active site
157239005054	catalytic residues [active]
157239005055	hypothetical protein; Reviewed; Region: PRK01736
157239005056	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
157239005057	proline aminopeptidase P II; Provisional; Region: PRK10879
157239005058	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
157239005059	active site
157239005060	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
157239005061	Ligand Binding Site [chemical binding]; other site
157239005062	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
157239005063	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
157239005064	motif 1; other site
157239005065	active site
157239005066	motif 2; other site
157239005067	motif 3; other site
157239005068	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
157239005069	Spectrin repeats; Region: SPEC; smart00150
157239005070	DHHA1 domain; Region: DHHA1; pfam02272
157239005071	carbon storage regulator; Provisional; Region: PRK01712
157239005072	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
157239005073	active site
157239005074	tetramer interface; other site
157239005075	argininosuccinate lyase; Provisional; Region: PRK04833
157239005076	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
157239005077	active sites [active]
157239005078	tetramer interface [polypeptide binding]; other site
157239005079	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
157239005080	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
157239005081	dimerization interface [polypeptide binding]; other site
157239005082	domain crossover interface; other site
157239005083	redox-dependent activation switch; other site
157239005084	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
157239005085	active site
157239005086	substrate-binding site [chemical binding]; other site
157239005087	metal-binding site [ion binding]
157239005088	ATP binding site [chemical binding]; other site
157239005089	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
157239005090	hinge region; other site
157239005091	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
157239005092	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
157239005093	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
157239005094	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
157239005095	Predicted permeases [General function prediction only]; Region: COG0730
157239005096	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
157239005097	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239005098	FeS/SAM binding site; other site
157239005099	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
157239005100	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
157239005101	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
157239005102	ligand binding site [chemical binding]; other site
157239005103	flexible hinge region; other site
157239005104	putative switch regulator; other site
157239005105	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
157239005106	non-specific DNA interactions [nucleotide binding]; other site
157239005107	DNA binding site [nucleotide binding]
157239005108	sequence specific DNA binding site [nucleotide binding]; other site
157239005109	putative cAMP binding site [chemical binding]; other site
157239005110	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
157239005111	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
157239005112	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
157239005113	alphaNTD homodimer interface [polypeptide binding]; other site
157239005114	alphaNTD - beta interaction site [polypeptide binding]; other site
157239005115	alphaNTD - beta' interaction site [polypeptide binding]; other site
157239005116	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
157239005117	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
157239005118	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
157239005119	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
157239005120	RNA binding surface [nucleotide binding]; other site
157239005121	30S ribosomal protein S11; Validated; Region: PRK05309
157239005122	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
157239005123	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
157239005124	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
157239005125	SecY translocase; Region: SecY; pfam00344
157239005126	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
157239005127	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
157239005128	23S rRNA binding site [nucleotide binding]; other site
157239005129	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
157239005130	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
157239005131	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
157239005132	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
157239005133	5S rRNA interface [nucleotide binding]; other site
157239005134	L27 interface [polypeptide binding]; other site
157239005135	23S rRNA interface [nucleotide binding]; other site
157239005136	L5 interface [polypeptide binding]; other site
157239005137	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
157239005138	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
157239005139	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
157239005140	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
157239005141	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
157239005142	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
157239005143	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
157239005144	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
157239005145	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
157239005146	RNA binding site [nucleotide binding]; other site
157239005147	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
157239005148	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
157239005149	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
157239005150	23S rRNA interface [nucleotide binding]; other site
157239005151	putative translocon interaction site; other site
157239005152	signal recognition particle (SRP54) interaction site; other site
157239005153	L23 interface [polypeptide binding]; other site
157239005154	trigger factor interaction site; other site
157239005155	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
157239005156	23S rRNA interface [nucleotide binding]; other site
157239005157	5S rRNA interface [nucleotide binding]; other site
157239005158	putative antibiotic binding site [chemical binding]; other site
157239005159	L25 interface [polypeptide binding]; other site
157239005160	L27 interface [polypeptide binding]; other site
157239005161	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
157239005162	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
157239005163	G-X-X-G motif; other site
157239005164	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
157239005165	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
157239005166	protein-rRNA interface [nucleotide binding]; other site
157239005167	putative translocon binding site; other site
157239005168	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
157239005169	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
157239005170	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
157239005171	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
157239005172	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
157239005173	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
157239005174	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
157239005175	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
157239005176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
157239005177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
157239005178	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
157239005179	dimerization interface [polypeptide binding]; other site
157239005180	acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920
157239005181	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
157239005182	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
157239005183	putative acyltransferase; Provisional; Region: PRK05790
157239005184	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
157239005185	dimer interface [polypeptide binding]; other site
157239005186	active site
157239005187	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
157239005188	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
157239005189	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
157239005190	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239005191	Walker A/P-loop; other site
157239005192	ATP binding site [chemical binding]; other site
157239005193	Q-loop/lid; other site
157239005194	ABC transporter signature motif; other site
157239005195	Walker B; other site
157239005196	D-loop; other site
157239005197	H-loop/switch region; other site
157239005198	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
157239005199	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
157239005200	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
157239005201	P loop; other site
157239005202	GTP binding site [chemical binding]; other site
157239005203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239005204	S-adenosylmethionine binding site [chemical binding]; other site
157239005205	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
157239005206	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
157239005207	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
157239005208	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
157239005209	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
157239005210	active site
157239005211	(T/H)XGH motif; other site
157239005212	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
157239005213	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
157239005214	active site
157239005215	metal binding site [ion binding]; metal-binding site
157239005216	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
157239005217	murein transglycosylase C; Provisional; Region: mltC; PRK11671
157239005218	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
157239005219	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
157239005220	N-acetyl-D-glucosamine binding site [chemical binding]; other site
157239005221	catalytic residue [active]
157239005222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924
157239005223	adenine DNA glycosylase; Provisional; Region: PRK10880
157239005224	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
157239005225	minor groove reading motif; other site
157239005226	helix-hairpin-helix signature motif; other site
157239005227	substrate binding pocket [chemical binding]; other site
157239005228	active site
157239005229	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
157239005230	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
157239005231	DNA binding and oxoG recognition site [nucleotide binding]
157239005232	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
157239005233	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
157239005234	catalytic core [active]
157239005235	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
157239005236	SPT2 chromatin protein; Region: SPT2; cl07029
157239005237	Peptidase family M23; Region: Peptidase_M23; pfam01551
157239005238	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
157239005239	NodB motif; other site
157239005240	putative active site [active]
157239005241	putative catalytic site [active]
157239005242	Zn binding site [ion binding]; other site
157239005243	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
157239005244	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
157239005245	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
157239005246	dimerization interface [polypeptide binding]; other site
157239005247	ATP binding site [chemical binding]; other site
157239005248	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
157239005249	dimerization interface [polypeptide binding]; other site
157239005250	ATP binding site [chemical binding]; other site
157239005251	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
157239005252	putative active site [active]
157239005253	catalytic triad [active]
157239005254	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
157239005255	dimer interface [polypeptide binding]; other site
157239005256	catalytic triad [active]
157239005257	peroxidatic and resolving cysteines [active]
157239005258	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
157239005259	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
157239005260	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
157239005261	LexA repressor; Validated; Region: PRK00215
157239005262	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
157239005263	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
157239005264	Catalytic site [active]
157239005265	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
157239005266	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
157239005267	putative acyl-acceptor binding pocket; other site
157239005268	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
157239005269	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
157239005270	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
157239005271	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
157239005272	active site residue [active]
157239005273	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
157239005274	SecA binding site; other site
157239005275	Preprotein binding site; other site
157239005276	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
157239005277	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
157239005278	active site
157239005279	substrate binding site [chemical binding]; other site
157239005280	metal binding site [ion binding]; metal-binding site
157239005281	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
157239005282	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
157239005283	putative active site [active]
157239005284	putative PHP Thumb interface [polypeptide binding]; other site
157239005285	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
157239005286	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
157239005287	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
157239005288	generic binding surface II; other site
157239005289	generic binding surface I; other site
157239005290	threonine dehydratase; Reviewed; Region: PRK09224
157239005291	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
157239005292	tetramer interface [polypeptide binding]; other site
157239005293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239005294	catalytic residue [active]
157239005295	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
157239005296	putative Ile/Val binding site [chemical binding]; other site
157239005297	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
157239005298	putative Ile/Val binding site [chemical binding]; other site
157239005299	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
157239005300	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
157239005301	PYR/PP interface [polypeptide binding]; other site
157239005302	dimer interface [polypeptide binding]; other site
157239005303	TPP binding site [chemical binding]; other site
157239005304	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
157239005305	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
157239005306	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
157239005307	Na2 binding site [ion binding]; other site
157239005308	putative substrate binding site 1 [chemical binding]; other site
157239005309	Na binding site 1 [ion binding]; other site
157239005310	putative substrate binding site 2 [chemical binding]; other site
157239005311	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
157239005312	putative active site [active]
157239005313	putative metal binding site [ion binding]; other site
157239005314	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
157239005315	putative acyl-acceptor binding pocket; other site
157239005316	FtsI repressor; Provisional; Region: PRK10883
157239005317	The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232
157239005318	Domain 2 interface [polypeptide binding]; other site
157239005319	Domain 3 interface [polypeptide binding]; other site
157239005320	trinuclear Cu binding site [ion binding]; other site
157239005321	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
157239005322	Domain 1 interface [polypeptide binding]; other site
157239005323	Domain 3 interface [polypeptide binding]; other site
157239005324	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
157239005325	Domain 2 interface [polypeptide binding]; other site
157239005326	Domain 1 interface [polypeptide binding]; other site
157239005327	Type 1 (T1) Cu binding site [ion binding]; other site
157239005328	trinuclear Cu binding site [ion binding]; other site
157239005329	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
157239005330	OstA-like protein; Region: OstA; pfam03968
157239005331	Organic solvent tolerance protein; Region: OstA_C; pfam04453
157239005332	prolyl-tRNA synthetase; Provisional; Region: PRK09194
157239005333	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
157239005334	dimer interface [polypeptide binding]; other site
157239005335	motif 1; other site
157239005336	active site
157239005337	motif 2; other site
157239005338	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
157239005339	putative deacylase active site [active]
157239005340	motif 3; other site
157239005341	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
157239005342	anticodon binding site; other site
157239005343	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
157239005344	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239005345	ATP binding site [chemical binding]; other site
157239005346	putative Mg++ binding site [ion binding]; other site
157239005347	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239005348	nucleotide binding region [chemical binding]; other site
157239005349	ATP-binding site [chemical binding]; other site
157239005350	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
157239005351	Helicase and RNase D C-terminal; Region: HRDC; smart00341
157239005352	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
157239005353	putative iron binding site [ion binding]; other site
157239005354	diaminopimelate decarboxylase; Region: lysA; TIGR01048
157239005355	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
157239005356	active site
157239005357	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
157239005358	substrate binding site [chemical binding]; other site
157239005359	catalytic residues [active]
157239005360	dimer interface [polypeptide binding]; other site
157239005361	transcriptional regulator NarP; Provisional; Region: PRK10403
157239005362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
157239005363	active site
157239005364	phosphorylation site [posttranslational modification]
157239005365	intermolecular recognition site; other site
157239005366	dimerization interface [polypeptide binding]; other site
157239005367	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
157239005368	DNA binding residues [nucleotide binding]
157239005369	dimerization interface [polypeptide binding]; other site
157239005370	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
157239005371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
157239005372	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
157239005373	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
157239005374	active site
157239005375	motif I; other site
157239005376	motif II; other site
157239005377	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
157239005378	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
157239005379	Walker A/P-loop; other site
157239005380	ATP binding site [chemical binding]; other site
157239005381	Q-loop/lid; other site
157239005382	ABC transporter signature motif; other site
157239005383	Walker B; other site
157239005384	D-loop; other site
157239005385	H-loop/switch region; other site
157239005386	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
157239005387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
157239005388	dimer interface [polypeptide binding]; other site
157239005389	conserved gate region; other site
157239005390	putative PBP binding loops; other site
157239005391	ABC-ATPase subunit interface; other site
157239005392	NLPA lipoprotein; Region: Lipoprotein_9; cl19159
157239005393	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
157239005394	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
157239005395	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
157239005396	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
157239005397	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
157239005398	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
157239005399	active site
157239005400	ATP-dependent helicase HepA; Validated; Region: PRK04914
157239005401	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
157239005402	ATP binding site [chemical binding]; other site
157239005403	putative Mg++ binding site [ion binding]; other site
157239005404	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
157239005405	nucleotide binding region [chemical binding]; other site
157239005406	ATP-binding site [chemical binding]; other site
157239005407	RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
157239005408	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
157239005409	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
157239005410	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
157239005411	L-fucose isomerase; Provisional; Region: fucI; PRK10991
157239005412	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
157239005413	hexamer (dimer of trimers) interface [polypeptide binding]; other site
157239005414	trimer interface [polypeptide binding]; other site
157239005415	substrate binding site [chemical binding]; other site
157239005416	Mn binding site [ion binding]; other site
157239005417	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
157239005418	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
157239005419	intersubunit interface [polypeptide binding]; other site
157239005420	active site
157239005421	Zn2+ binding site [ion binding]; other site
157239005422	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
157239005423	L-fucose transporter; Provisional; Region: PRK10133; cl17665
157239005424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239005425	putative substrate translocation pore; other site
157239005426	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
157239005427	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
157239005428	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
157239005429	homodimer interface [polypeptide binding]; other site
157239005430	NADP binding site [chemical binding]; other site
157239005431	substrate binding site [chemical binding]; other site
157239005432	anion transporter; Region: dass; TIGR00785
157239005433	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
157239005434	transmembrane helices; other site
157239005435	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
157239005436	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
157239005437	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
157239005438	shikimate binding site; other site
157239005439	NAD(P) binding site [chemical binding]; other site
157239005440	serine acetyltransferase; Provisional; Region: cysE; PRK11132
157239005441	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
157239005442	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
157239005443	trimer interface [polypeptide binding]; other site
157239005444	active site
157239005445	substrate binding site [chemical binding]; other site
157239005446	CoA binding site [chemical binding]; other site
157239005447	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
157239005448	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
157239005449	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
157239005450	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
157239005451	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
157239005452	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
157239005453	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
157239005454	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
157239005455	HemY protein N-terminus; Region: HemY_N; pfam07219
157239005456	Phage portal protein; Region: Phage_portal; cl19194
157239005457	terminase ATPase subunit; Provisional; Region: P; PHA02535
157239005458	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
157239005459	Phage Terminase; Region: Terminase_1; cl19862
157239005460	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
157239005461	capsid protein; Provisional; Region: N; PHA02538
157239005462	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
157239005463	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
157239005464	Phage Tail Protein X; Region: Phage_tail_X; cl02088
157239005465	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
157239005466	catalytic residues [active]
157239005467	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
157239005468	DksA-like zinc finger domain containing protein; Region: PHA00080
157239005469	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
157239005470	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
157239005471	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
157239005472	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
157239005473	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
157239005474	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901
157239005475	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
157239005476	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
157239005477	Baseplate J-like protein; Region: Baseplate_J; cl01294
157239005478	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
157239005479	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
157239005480	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
157239005481	Phage Tail Collar Domain; Region: Collar; pfam07484
157239005482	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
157239005483	Phage tail tube protein FII; Region: Phage_tube; pfam04985
157239005484	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
157239005485	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
157239005486	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
157239005487	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
157239005488	tail protein; Provisional; Region: D; PHA02561
157239005489	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
157239005490	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
157239005491	Dimer interface [polypeptide binding]; other site
157239005492	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239005493	non-specific DNA binding site [nucleotide binding]; other site
157239005494	Predicted transcriptional regulator [Transcription]; Region: COG2932
157239005495	salt bridge; other site
157239005496	sequence-specific DNA binding site [nucleotide binding]; other site
157239005497	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
157239005498	Catalytic site [active]
157239005499	DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770
157239005500	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
157239005501	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540
157239005502	putative metal binding site [ion binding]; other site
157239005503	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
157239005504	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
157239005505	active site
157239005506	DNA binding site [nucleotide binding]
157239005507	Int/Topo IB signature motif; other site
157239005508	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
157239005509	Cation transport protein; Region: TrkH; cl17365
157239005510	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
157239005511	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
157239005512	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
157239005513	sulfur transfer protein SirA; Reviewed; Region: PRK00299
157239005514	CPxP  motif; other site
157239005515	heat shock protein HtpX; Provisional; Region: PRK05457
157239005516	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
157239005517	homotrimer interaction site [polypeptide binding]; other site
157239005518	putative active site [active]
157239005519	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
157239005520	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
157239005521	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
157239005522	putative homodimer interface [polypeptide binding]; other site
157239005523	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
157239005524	heterodimer interface [polypeptide binding]; other site
157239005525	homodimer interface [polypeptide binding]; other site
157239005526	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
157239005527	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
157239005528	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
157239005529	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
157239005530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239005531	Walker A motif; other site
157239005532	ATP binding site [chemical binding]; other site
157239005533	Walker B motif; other site
157239005534	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
157239005535	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
157239005536	oligomer interface [polypeptide binding]; other site
157239005537	active site residues [active]
157239005538	trigger factor; Provisional; Region: tig; PRK01490
157239005539	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
157239005540	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
157239005541	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
157239005542	PT repeat; Region: PT; pfam04886
157239005543	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
157239005544	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
157239005545	Lipoprotein leucine-zipper; Region: LPP; cl11539
157239005546	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
157239005547	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
157239005548	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
157239005549	G1 box; other site
157239005550	putative GEF interaction site [polypeptide binding]; other site
157239005551	GTP/Mg2+ binding site [chemical binding]; other site
157239005552	Switch I region; other site
157239005553	G2 box; other site
157239005554	G3 box; other site
157239005555	Switch II region; other site
157239005556	G4 box; other site
157239005557	G5 box; other site
157239005558	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
157239005559	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
157239005560	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
157239005561	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
157239005562	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
157239005563	selenocysteine synthase; Provisional; Region: PRK04311
157239005564	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
157239005565	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
157239005566	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
157239005567	catalytic residue [active]
157239005568	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
157239005569	MutS domain I; Region: MutS_I; pfam01624
157239005570	MutS domain II; Region: MutS_II; pfam05188
157239005571	MutS domain III; Region: MutS_III; pfam05192
157239005572	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
157239005573	Walker A/P-loop; other site
157239005574	ATP binding site [chemical binding]; other site
157239005575	Q-loop/lid; other site
157239005576	ABC transporter signature motif; other site
157239005577	Walker B; other site
157239005578	D-loop; other site
157239005579	H-loop/switch region; other site
157239005580	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
157239005581	aromatic amino acid transport protein; Region: araaP; TIGR00837
157239005582	Tryptophanase [Amino acid transport and metabolism]; Region: TnaA; COG3033
157239005583	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
157239005584	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
157239005585	catalytic residue [active]
157239005586	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
157239005587	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
157239005588	Peptidase family M23; Region: Peptidase_M23; pfam01551
157239005589	Predicted membrane protein [Function unknown]; Region: COG1238
157239005590	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
157239005591	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
157239005592	Permutation of conserved domain; other site
157239005593	active site
157239005594	RNase E inhibitor protein; Provisional; Region: PRK11191
157239005595	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
157239005596	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
157239005597	DNA methylase; Region: N6_N4_Mtase; cl17433
157239005598	DNA methylase; Region: N6_N4_Mtase; pfam01555
157239005599	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
157239005600	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519
157239005601	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
157239005602	Surface antigen; Region: Bac_surface_Ag; pfam01103
157239005603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
157239005604	Family of unknown function (DUF490); Region: DUF490; pfam04357
157239005605	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
157239005606	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
157239005607	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
157239005608	probable active site [active]
157239005609	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
157239005610	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239005611	active site
157239005612	glycerol kinase; Provisional; Region: glpK; PRK00047
157239005613	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
157239005614	N- and C-terminal domain interface [polypeptide binding]; other site
157239005615	active site
157239005616	MgATP binding site [chemical binding]; other site
157239005617	catalytic site [active]
157239005618	metal binding site [ion binding]; metal-binding site
157239005619	glycerol binding site [chemical binding]; other site
157239005620	homotetramer interface [polypeptide binding]; other site
157239005621	homodimer interface [polypeptide binding]; other site
157239005622	FBP binding site [chemical binding]; other site
157239005623	protein IIAGlc interface [polypeptide binding]; other site
157239005624	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
157239005625	amphipathic channel; other site
157239005626	Asn-Pro-Ala signature motifs; other site
157239005627	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
157239005628	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
157239005629	active site
157239005630	catalytic site [active]
157239005631	metal binding site [ion binding]; metal-binding site
157239005632	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
157239005633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
157239005634	putative substrate translocation pore; other site
157239005635	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
157239005636	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
157239005637	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
157239005638	FAD binding domain; Region: FAD_binding_2; pfam00890
157239005639	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
157239005640	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
157239005641	Cysteine-rich domain; Region: CCG; pfam02754
157239005642	Cysteine-rich domain; Region: CCG; pfam02754
157239005643	ketol-acid reductoisomerase; Validated; Region: PRK05225
157239005644	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
157239005645	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
157239005646	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
157239005647	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
157239005648	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
157239005649	putative dimerization interface [polypeptide binding]; other site
157239005650	rarD protein; Region: rarD; TIGR00688
157239005651	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
157239005652	active site residue [active]
157239005653	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
157239005654	substrate binding site [chemical binding]; other site
157239005655	dimer interface [polypeptide binding]; other site
157239005656	catalytic triad [active]
157239005657	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
157239005658	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
157239005659	active site
157239005660	Int/Topo IB signature motif; other site
157239005661	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
157239005662	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
157239005663	metal binding site [ion binding]; metal-binding site
157239005664	dimer interface [polypeptide binding]; other site
157239005665	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
157239005666	active site
157239005667	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
157239005668	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
157239005669	substrate binding site; other site
157239005670	dimer interface; other site
157239005671	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
157239005672	homotrimer interaction site [polypeptide binding]; other site
157239005673	zinc binding site [ion binding]; other site
157239005674	CDP-binding sites; other site
157239005675	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
157239005676	putative active site [active]
157239005677	dimerization interface [polypeptide binding]; other site
157239005678	putative tRNAtyr binding site [nucleotide binding]; other site
157239005679	FMN-binding protein MioC; Provisional; Region: PRK09004
157239005680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074
157239005681	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
157239005682	putative active site [active]
157239005683	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239005684	non-specific DNA binding site [nucleotide binding]; other site
157239005685	salt bridge; other site
157239005686	sequence-specific DNA binding site [nucleotide binding]; other site
157239005687	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
157239005688	HipA N-terminal domain; Region: Couple_hipA; pfam13657
157239005689	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
157239005690	HipA-like N-terminal domain; Region: HipA_N; pfam07805
157239005691	HipA-like C-terminal domain; Region: HipA_C; pfam07804
157239005692	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
157239005693	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
157239005694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239005695	Walker A/P-loop; other site
157239005696	ATP binding site [chemical binding]; other site
157239005697	Q-loop/lid; other site
157239005698	ABC transporter signature motif; other site
157239005699	Walker B; other site
157239005700	D-loop; other site
157239005701	H-loop/switch region; other site
157239005702	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
157239005703	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
157239005704	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239005705	Walker A/P-loop; other site
157239005706	ATP binding site [chemical binding]; other site
157239005707	Q-loop/lid; other site
157239005708	ABC transporter signature motif; other site
157239005709	Walker B; other site
157239005710	D-loop; other site
157239005711	H-loop/switch region; other site
157239005712	PT repeat; Region: PT; pfam04886
157239005713	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
157239005714	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
157239005715	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
157239005716	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239005717	non-specific DNA binding site [nucleotide binding]; other site
157239005718	salt bridge; other site
157239005719	sequence-specific DNA binding site [nucleotide binding]; other site
157239005720	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
157239005721	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
157239005722	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
157239005723	Walker A/P-loop; other site
157239005724	ATP binding site [chemical binding]; other site
157239005725	Q-loop/lid; other site
157239005726	ABC transporter signature motif; other site
157239005727	ABC transporter; Region: ABC_tran_2; pfam12848
157239005728	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
157239005729	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
157239005730	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
157239005731	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
157239005732	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
157239005733	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
157239005734	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
157239005735	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
157239005736	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
157239005737	shikimate binding site; other site
157239005738	NAD(P) binding site [chemical binding]; other site
157239005739	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
157239005740	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
157239005741	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
157239005742	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
157239005743	putative metal binding site; other site
157239005744	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
157239005745	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
157239005746	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
157239005747	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
157239005748	active site
157239005749	(T/H)XGH motif; other site
157239005750	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5645
157239005751	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
157239005752	Part of AAA domain; Region: AAA_19; pfam13245
157239005753	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
157239005754	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
157239005755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239005756	Walker A motif; other site
157239005757	ATP binding site [chemical binding]; other site
157239005758	Walker B motif; other site
157239005759	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
157239005760	Domain of unknown function (DUF4209); Region: DUF4209; pfam13910
157239005761	Transcriptional regulator [Transcription]; Region: LysR; COG0583
157239005762	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
157239005763	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
157239005764	dimerization interface [polypeptide binding]; other site
157239005765	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
157239005766	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
157239005767	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
157239005768	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
157239005769	FeS/SAM binding site; other site
157239005770	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
157239005771	MgtC family; Region: MgtC; pfam02308
157239005772	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
157239005773	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
157239005774	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
157239005775	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
157239005776	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
157239005777	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
157239005778	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
157239005779	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
157239005780	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
157239005781	molybdopterin cofactor binding site [chemical binding]; other site
157239005782	substrate binding site [chemical binding]; other site
157239005783	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
157239005784	molybdopterin cofactor binding site; other site
157239005785	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
157239005786	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
157239005787	Substrate binding site; other site
157239005788	Mg++ binding site; other site
157239005789	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
157239005790	active site
157239005791	substrate binding site [chemical binding]; other site
157239005792	CoA binding site [chemical binding]; other site
157239005793	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
157239005794	core dimer interface [polypeptide binding]; other site
157239005795	peripheral dimer interface [polypeptide binding]; other site
157239005796	L10 interface [polypeptide binding]; other site
157239005797	L11 interface [polypeptide binding]; other site
157239005798	putative EF-Tu interaction site [polypeptide binding]; other site
157239005799	putative EF-G interaction site [polypeptide binding]; other site
157239005800	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
157239005801	23S rRNA interface [nucleotide binding]; other site
157239005802	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
157239005803	adenylosuccinate lyase; Provisional; Region: PRK09285
157239005804	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
157239005805	tetramer interface [polypeptide binding]; other site
157239005806	active site
157239005807	Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915
157239005808	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
157239005809	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
157239005810	active site
157239005811	HIGH motif; other site
157239005812	dimer interface [polypeptide binding]; other site
157239005813	KMSKS motif; other site
157239005814	conserved hypothetical protein; Region: TIGR00743
157239005815	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
157239005816	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
157239005817	FMN binding site [chemical binding]; other site
157239005818	active site
157239005819	catalytic residues [active]
157239005820	substrate binding site [chemical binding]; other site
157239005821	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
157239005822	elongation factor Tu; Reviewed; Region: PRK00049
157239005823	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
157239005824	G1 box; other site
157239005825	GEF interaction site [polypeptide binding]; other site
157239005826	GTP/Mg2+ binding site [chemical binding]; other site
157239005827	Switch I region; other site
157239005828	G2 box; other site
157239005829	G3 box; other site
157239005830	Switch II region; other site
157239005831	G4 box; other site
157239005832	G5 box; other site
157239005833	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
157239005834	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
157239005835	Antibiotic Binding Site [chemical binding]; other site
157239005836	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
157239005837	ATP-binding site [chemical binding]; other site
157239005838	CoA-binding site [chemical binding]; other site
157239005839	Mg2+-binding site [ion binding]; other site
157239005840	anti-sigma E factor; Provisional; Region: rseB; PRK09455
157239005841	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
157239005842	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
157239005843	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
157239005844	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
157239005845	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
157239005846	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
157239005847	DNA binding residues [nucleotide binding]
157239005848	Uncharacterized conserved protein [Function unknown]; Region: COG2938
157239005849	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
157239005850	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
157239005851	TrkA-N domain; Region: TrkA_N; pfam02254
157239005852	TrkA-C domain; Region: TrkA_C; pfam02080
157239005853	TrkA-N domain; Region: TrkA_N; pfam02254
157239005854	TrkA-C domain; Region: TrkA_C; pfam02080
157239005855	16S rRNA methyltransferase B; Provisional; Region: PRK10901
157239005856	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
157239005857	putative RNA binding site [nucleotide binding]; other site
157239005858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
157239005859	S-adenosylmethionine binding site [chemical binding]; other site
157239005860	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
157239005861	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
157239005862	putative active site [active]
157239005863	substrate binding site [chemical binding]; other site
157239005864	putative cosubstrate binding site; other site
157239005865	catalytic site [active]
157239005866	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
157239005867	substrate binding site [chemical binding]; other site
157239005868	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
157239005869	active site
157239005870	catalytic residues [active]
157239005871	metal binding site [ion binding]; metal-binding site
157239005872	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
157239005873	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
157239005874	TfoX C-terminal domain; Region: TfoX_C; pfam04994
157239005875	recombinase A; Provisional; Region: recA; PRK09354
157239005876	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
157239005877	hexamer interface [polypeptide binding]; other site
157239005878	Walker A motif; other site
157239005879	ATP binding site [chemical binding]; other site
157239005880	Walker B motif; other site
157239005881	recombination regulator RecX; Reviewed; Region: recX; PRK00117
157239005882	CrcB-like protein; Region: CRCB; cl09114
157239005883	putative hydrolase; Provisional; Region: PRK10976
157239005884	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
157239005885	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
157239005886	active site
157239005887	motif I; other site
157239005888	motif II; other site
157239005889	ornithine carbamoyltransferase; Provisional; Region: PRK01713
157239005890	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
157239005891	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
157239005892	ornithine decarboxylase; Provisional; Region: PRK13578
157239005893	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
157239005894	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
157239005895	homodimer interface [polypeptide binding]; other site
157239005896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
157239005897	catalytic residue [active]
157239005898	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
157239005899	putrescine transporter; Provisional; Region: potE; PRK10655
157239005900	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
157239005901	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
157239005902	allantoate amidohydrolase; Reviewed; Region: PRK09290
157239005903	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
157239005904	active site
157239005905	metal binding site [ion binding]; metal-binding site
157239005906	dimer interface [polypeptide binding]; other site
157239005907	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
157239005908	active site pocket [active]
157239005909	oxyanion hole [active]
157239005910	catalytic triad [active]
157239005911	active site nucleophile [active]
157239005912	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
157239005913	c4-dicarboxylate anaerobic carrier family protein; Region: DcuC; TIGR00771
157239005914	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
157239005915	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
157239005916	putative metal binding site [ion binding]; other site
157239005917	dimer interface [polypeptide binding]; other site
157239005918	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
157239005919	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
157239005920	active site
157239005921	metal binding site [ion binding]; metal-binding site
157239005922	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
157239005923	AAA ATPase domain; Region: AAA_16; pfam13191
157239005924	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
157239005925	G1 box; other site
157239005926	GTP/Mg2+ binding site [chemical binding]; other site
157239005927	G2 box; other site
157239005928	Switch I region; other site
157239005929	G3 box; other site
157239005930	Switch II region; other site
157239005931	G4 box; other site
157239005932	G5 box; other site
157239005933	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
157239005934	AAA domain; Region: AAA_30; pfam13604
157239005935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
157239005936	Walker A motif; other site
157239005937	ATP binding site [chemical binding]; other site
157239005938	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
157239005939	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
157239005940	non-specific DNA binding site [nucleotide binding]; other site
157239005941	salt bridge; other site
157239005942	sequence-specific DNA binding site [nucleotide binding]; other site
157239005943	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
157239005944	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
157239005945	DNA binding residues [nucleotide binding]
157239005946	dimer interface [polypeptide binding]; other site
157239005947	putative metal binding site [ion binding]; other site
157239005948	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230