-- dump date   	20140619_104923
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_002474655.1	COG:G;COG0057
YP_002474656.1	COG:L;COG0188
YP_002474658.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_002474659.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_002474660.1	COG:C;COG3029
YP_002474661.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_002474662.1	putative role in sulfur assimilation
YP_002474663.1	interacts with cell division protein FitsZ and may be required to anchor septal ring structure
YP_002474664.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_002474665.1	COG:L;COG0514
YP_002474666.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_002474667.1	Represses a number of genes involved in the response to DNA damage
YP_002474670.1	COG:R;COG0790
YP_002474671.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_002474672.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_002474673.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_002474674.1	COG:V;COG1131
YP_002474675.1	COG:V;COG0842
YP_002474676.1	COG:D;COG2161
YP_002474677.1	COG:JD;COG2026
YP_002474678.1	COG:L;COG2925
YP_002474679.1	COG:S;COG1912
YP_002474680.1	COG:R;COG0613
YP_002474681.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_002474682.1	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
YP_002474683.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_002474684.1	COG:V;COG0841
YP_002474685.1	COG:M;COG0845
YP_002474686.1	COG:K;COG1309
YP_002474687.1	involved in de novo purine biosynthesis
YP_002474688.1	catalyzes the formation of L-homocysteine from cystathionine
YP_002474689.1	COG:L;COG0350
YP_002474690.1	COG:I;COG2067
YP_002474691.1	COG:S;COG3691
YP_002474692.1	COG:S;COG4636
YP_002474693.1	COG:M;COG1083
YP_002474694.1	involved in the export of O-antigen and teichoic acid/lipopolysaccharide biosynthesis protein; COG:R;COG2244
YP_002474698.1	COG:M;COG0463
YP_002474699.1	involved in lipopolysaccharide biosynthesis, spore coat polysaccharide biosynthesis protein C/glycosyltransferase; COG:M;COG0399
YP_002474700.1	COG:M;COG2148
YP_002474701.1	COG:MG;COG1086
YP_002474702.1	COG:M;COG1596
YP_002474703.1	COG:T;COG0394
YP_002474704.1	COG:M;COG3206
YP_002474705.1	COG:K;COG1959
YP_002474706.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_002474707.1	COG:C;COG0822
YP_002474708.1	COG:S;COG0316
YP_002474709.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_002474710.1	COG:L;COG3547
YP_002474712.1	COG:O;COG0443
YP_002474713.1	COG:C;COG0633
YP_002474714.1	COG:S;COG2975
YP_002474715.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_002474716.1	COG:T;COG1217
YP_002474717.1	functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase
YP_002474719.1	COG:C;COG1271
YP_002474720.1	COG:C;COG1294
YP_002474721.1	COG:S;COG3790
YP_002474722.1	COG:R;COG0824
YP_002474723.1	COG:U;COG0811
YP_002474724.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_002474725.1	involved in colicin uptake, membrane spanning protein in TolA-TolQ-TolR complex
YP_002474726.1	forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_002474727.1	COG:M;COG2885
YP_002474728.1	functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system
YP_002474729.1	COG:S;COG3647
YP_002474730.1	COG:J;COG0042
YP_002474731.1	COG:S;COG3768
YP_002474732.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_002474733.1	involved in the processing of the 5'end of 16S rRNA
YP_002474734.1	COG:E;COG0687
YP_002474735.1	COG:S;COG3117
YP_002474736.1	COG:S;COG1934
YP_002474737.1	COG:R;COG1137
YP_002474738.1	COG:GT;COG1762
YP_002474739.1	COG:R;COG1660
YP_002474740.1	COG:HC;COG0654
YP_002474742.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_002474743.1	COG:E;COG0747
YP_002474745.1	COG:G;COG0058
YP_002474747.1	COG:O;COG1495
YP_002474748.1	Multifunctional regulator of fatty acid metabolism
YP_002474749.1	COG:H;COG1477
YP_002474750.1	COG:S;COG2991
YP_002474753.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_002474754.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_002474755.1	COG:G;COG0483
YP_002474756.1	COG:L;COG3547
YP_002474757.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_002474758.1	COG:M;COG0275
YP_002474759.1	COG:D;COG3116
YP_002474760.1	COG:M;COG0768
YP_002474761.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_002474762.1	COG:M;COG0770
YP_002474763.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_002474764.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_002474765.1	COG:D;COG0772
YP_002474766.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_002474767.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_002474768.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_002474769.1	COG:M;COG1589
YP_002474770.1	COG:D;COG0849
YP_002474771.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_002474772.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_002474773.1	involved in the import of serine and threonine coupled with the import of sodium
YP_002474774.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_002474775.1	COG:L;COG3547
YP_002474776.1	COG:U;COG0681
YP_002474777.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_002474778.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_002474779.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_002474780.1	COG:L;COG1943
YP_002474781.1	Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine
YP_002474782.1	Catalyzes the phosphorylation of UMP to UDP
YP_002474783.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_002474784.1	COG:J;COG0233
YP_002474786.1	COG:R;COG2252
YP_002474787.1	COG:R;COG0628
YP_002474788.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_002474789.1	COG:R;COG3030
YP_002474790.1	COG:EH;COG0028
YP_002474791.1	COG:S;COG3978
YP_002474793.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_002474794.1	COG:F;COG0105
YP_002474796.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_002474797.1	COG:S;COG1238
YP_002474798.1	COG:P;COG2116
YP_002474799.1	COG:C;COG1882
YP_002474800.1	COG:O;COG1180
YP_002474802.1	COG:R;COG2985
YP_002474803.1	COG:E;COG0786
YP_002474804.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_002474805.1	COG:S;COG3105
YP_002474806.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_002474807.1	forms a direct contact with the tRNA during translation
YP_002474808.1	COG:M;COG3203
YP_002474809.1	COG:J;COG0565
YP_002474810.1	COG:P;COG1840
YP_002474811.1	Global transcription factor that controls the expression of over 100 target genes in response to anoxia
YP_002474813.1	COG:QR;COG0500
YP_002474814.1	COG:L;COG0305
YP_002474815.1	COG:S;COG3100
YP_002474816.1	COG:K;COG1327
YP_002474817.1	COG:E;COG1509
YP_002474819.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_002474821.1	COG:S;COG3074
YP_002474822.1	COG:F;COG1435
YP_002474823.1	COG:R;COG0637
YP_002474824.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_002474825.1	COG:R;COG0670
YP_002474826.1	COG:O;COG0542
YP_002474827.1	COG:O;COG1651
YP_002474828.1	COG:M;COG0739
YP_002474829.1	COG:P;COG1121
YP_002474830.1	COG:P;COG1108
YP_002474831.1	COG:R;COG0121
YP_002474832.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources
YP_002474833.1	COG:G;COG2893
YP_002474834.1	COG:G;COG1874
YP_002474835.1	COG:G;COG3716
YP_002474836.1	COG:G;COG3715
YP_002474837.1	COG:G;COG3444
YP_002474838.1	COG:M;COG2222
YP_002474839.1	COG:KG;COG1349
YP_002474840.1	Required for efficient pilin antigenic variation
YP_002474841.1	COG:P;COG1178
YP_002474842.1	Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import
YP_002474843.1	COG:S;COG0779
YP_002474844.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_002474845.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_002474848.1	COG:K;COG0583
YP_002474849.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_002474850.1	COG:R;COG3083
YP_002474851.1	COG:S;COG3082
YP_002474852.1	catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position
YP_002474853.1	Required for the synthesis of the thiazole moiety
YP_002474854.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_002474855.1	COG:T;COG3026
YP_002474856.1	COG:T;COG3086
YP_002474857.1	Activates fatty acids by binding to coenzyme A
YP_002474858.1	COG:D;COG4942
YP_002474859.1	COG:S;COG2861
YP_002474860.1	COG:M;COG0729
YP_002474861.1	COG:S;COG2911
YP_002474863.1	involved in cytochrome bd biosynthesis, CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydD; in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_002474864.1	involved in cytochrome bd biosynthesis, cysteine exporter (CydDC-E) family permease/ATP-binding protein CydC; in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_002474865.1	COG:LR;COG0494
YP_002474866.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_002474868.1	COG:S;COG4701
YP_002474869.1	COG:MP;COG3015
YP_002474870.1	COG:H;COG0801
YP_002474871.1	COG:J;COG0617
YP_002474872.1	COG:T;COG1734
YP_002474873.1	amylomaltase; acts to release glucose from maltodextrins
YP_002474874.1	with MalKFE is involved in the transport of maltose into the cell
YP_002474875.1	with MalKGE is involved in maltose transport into the cell
YP_002474876.1	functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis
YP_002474877.1	with malEFG is involved in import of maltose/maltodextrin
YP_002474878.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_002474887.1	participates with LolB in the incorporation of lipoprotein into the outer membrane
YP_002474888.1	When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription
YP_002474889.1	COG:M;COG0744
YP_002474890.1	COG:P;COG0600
YP_002474891.1	COG:P;COG0715
YP_002474892.1	COG:P;COG1116
YP_002474893.1	COG:I;COG1960
YP_002474894.1	COG:S;COG2128
YP_002474895.1	COG:HJ;COG0189
YP_002474896.1	acts with MukB and MukE to condense the chromosome and allow for segregation during cell division
YP_002474897.1	acts with MukB and MukF to condense the chromosome and allow for segregation during cell division
YP_002474898.1	COG:L;COG0270
YP_002474900.1	SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects
YP_002474901.1	catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
YP_002474902.1	COG:C;COG0778
YP_002474903.1	COG:S;COG3691
YP_002474908.1	catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002474909.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_002474910.1	COG:L;COG0608
YP_002474911.1	COG:M;COG2885
YP_002474912.1	COG:R;COG0561
YP_002474913.1	COG:M;COG1247
YP_002474914.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_002474915.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_002474916.1	COG:S;COG3022
YP_002474917.1	COG:J;COG0052
YP_002474918.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_002474919.1	COG:C;COG1526
YP_002474920.1	COG:C;COG0243
YP_002474921.1	COG:C;COG0243
YP_002474922.1	COG:C;COG0437
YP_002474923.1	COG:C;COG2864
YP_002474925.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_002474926.1	COG:G;COG1523
YP_002474927.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_002474928.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_002474929.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_002474930.1	COG:M;COG3955
YP_002474932.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_002474934.1	COG:R;COG0727
YP_002474938.1	COG:S;COG4735
YP_002474941.1	COG:K;COG2378
YP_002474942.1	COG:K;COG1396
YP_002474943.1	removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction
YP_002474944.1	COG:R;COG2056
YP_002474945.1	COG:D;COG0037
YP_002474947.1	COG:H;COG0163
YP_002474949.1	COG:S;COG3787
YP_002474950.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_002474951.1	catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_002474952.1	mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system
YP_002474953.1	COG:D;COG1674
YP_002474954.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_002474955.1	COG:O;COG1214
YP_002474960.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_002474961.1	COG:L;COG0187
YP_002474963.1	COG:O;COG0425
YP_002474964.1	COG:S;COG3094
YP_002474965.1	COG:S;COG3028
YP_002474966.1	COG:R;COG0312
YP_002474967.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_002474968.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_002474970.1	Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance
YP_002474971.1	COG:J;COG1187
YP_002474972.1	part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
YP_002474973.1	COG:TK;COG0745
YP_002474974.1	COG:R;COG1694
YP_002474975.1	COG:E;COG0006
YP_002474976.1	COG:D;COG4118
YP_002474977.1	unknown function but a role in signaling; COG:S;COG3744
YP_002474978.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_002474979.1	COG:L;COG3547
YP_002474980.1	COG:V;COG0286
YP_002474981.1	COG:V;COG0732
YP_002474982.1	COG:V;COG0610
YP_002474983.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_002474985.1	catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002474986.1	COG:P;COG1629
YP_002474987.1	COG:FP;COG0248
YP_002474988.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_002474989.1	COG:E;COG0128
YP_002474990.1	COG:K;COG1278
YP_002474991.1	COG:O;COG1225
YP_002474992.1	Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate
YP_002474993.1	COG:F;COG0634
YP_002474994.1	COG:M;COG0741
YP_002474996.1	COG:P;COG0053
YP_002474997.1	COG:L;COG3547
YP_002474998.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_002474999.1	COG:S;COG3112
YP_002475000.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_002475001.1	COG:L;COG0629
YP_002475002.1	COG:R;COG1373
YP_002475003.1	COG:LKJ;COG0513
YP_002475004.1	COG:R;COG3093
YP_002475005.1	COG:R;COG3549
YP_002475006.1	catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway
YP_002475007.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_002475008.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_002475009.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_002475011.1	COG:R;COG0596
YP_002475012.1	negative modulator of the initiation of chromosome replication
YP_002475013.1	COG:IQ;COG0318
YP_002475014.1	small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS
YP_002475015.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_002475016.1	COG:R;COG3549
YP_002475017.1	COG:R;COG3093
YP_002475018.1	COG:KG;COG1940
YP_002475019.1	COG:J;COG0349
YP_002475020.1	COG:C;COG0282
YP_002475022.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_002475023.1	COG:R;COG2984
YP_002475024.1	COG:R;COG2969
YP_002475025.1	COG:O;COG0625
YP_002475026.1	COG:S;COG2926
YP_002475027.1	COG:H;COG0285
YP_002475028.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_002475029.1	COG:T;COG2337
YP_002475030.1	COG:T;COG2336
YP_002475031.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_002475032.1	COG:GER;COG0697
YP_002475033.1	COG:R;COG2081
YP_002475034.1	COG:EM;COG0329
YP_002475035.1	COG:K;COG1737
YP_002475036.1	COG:G;COG2731
YP_002475037.1	COG:R;COG3549
YP_002475038.1	COG:R;COG3093
YP_002475039.1	COG:S;COG4672
YP_002475042.1	COG:S;COG4718
YP_002475046.1	COG:U;COG1314
YP_002475047.1	decatenates replicating daughter chromosomes
YP_002475048.1	D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm
YP_002475049.1	COG:S;COG2363
YP_002475050.1	COG:K;COG5499
YP_002475051.1	COG:S;COG4680
YP_002475053.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_002475054.1	COG:H;COG0315
YP_002475055.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_002475056.1	COG:H;COG0314
YP_002475057.1	COG:R;COG0319
YP_002475058.1	COG:R;COG1444
YP_002475059.1	COG:G;COG1879
YP_002475060.1	with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains
YP_002475061.1	ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex
YP_002475062.1	COG:P;COG1464
YP_002475063.1	COG:P;COG1464
YP_002475064.1	COG:P;COG2011
YP_002475065.1	part of the metNIQ transport system for methionine
YP_002475066.1	COG:U;COG2095
YP_002475067.1	COG:E;COG4166
YP_002475068.1	COG:D;COG0489
YP_002475069.1	catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis
YP_002475070.1	ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase
YP_002475071.1	COG:J;COG0023
YP_002475072.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_002475073.1	COG:G;COG2956
YP_002475074.1	COG:S;COG3771
YP_002475075.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_002475076.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_002475077.1	COG:F;COG0283
YP_002475078.1	COG:O;COG0265
YP_002475079.1	COG:M;COG1210
YP_002475080.1	affects carbohydrate metabolism; has regulatory role in many processes
YP_002475081.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002475082.1	COG:T;COG0589
YP_002475083.1	COG:R;COG0658
YP_002475084.1	unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity
YP_002475085.1	COG:I;COG1607
YP_002475086.1	Involved in cell division; probably involved in intracellular septation
YP_002475088.1	COG:S;COG3092
YP_002475089.1	COG:FJ;COG0590
YP_002475090.1	COG:LKJ;COG0513
YP_002475091.1	lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing
YP_002475092.1	COG:J;COG1185
YP_002475093.1	catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides
YP_002475094.1	COG:M;COG0818
YP_002475095.1	COG:T;COG0642
YP_002475096.1	determines N-hexane tolerance and is involved in outer membrane permeability
YP_002475097.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_002475099.1	COG:S;COG3078
YP_002475100.1	COG:S;COG2949
YP_002475101.1	COG:GER;COG0697
YP_002475102.1	COG:K;COG2183
YP_002475103.1	E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_002475104.1	COG:C;COG0508
YP_002475105.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_002475107.1	COG:F;COG0041
YP_002475108.1	COG:EJ;COG0252
YP_002475109.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_002475110.1	COG:O;COG0652
YP_002475111.1	Involved in ubiquinone biosynthesis
YP_002475112.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_002475113.1	catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules
YP_002475114.1	COG:S;COG0327
YP_002475115.1	COG:H;COG0303
YP_002475116.1	COG:L;COG3547
YP_002475117.1	COG:U;COG2095
YP_002475119.1	COG:O;COG0465
YP_002475120.1	Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit
YP_002475121.1	COG:I;COG0623
YP_002475123.1	COG:K;COG2944
YP_002475124.1	COG:JD;COG2026
YP_002475125.1	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YP_002475126.1	membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_002475129.1	COG:S;COG0586
YP_002475130.1	binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers
YP_002475131.1	involved in methylation of ribosomal protein L3
YP_002475132.1	COG:S;COG2840
YP_002475133.1	COG:E;COG0814
YP_002475134.1	COG:E;COG0814
YP_002475135.1	COG:OC;COG0526
YP_002475136.1	COG:O;COG0785
YP_002475137.1	COG:O;COG0225
YP_002475139.1	COG:K;COG1595
YP_002475143.1	COG:R;COG3772
YP_002475146.1	COG:T;COG1734
YP_002475150.1	COG:S;COG5283
YP_002475154.1	COG:N;COG1724
YP_002475155.1	COG:S;COG1598
YP_002475163.1	COG:KT;COG1974
YP_002475167.1	COG:S;COG1598
YP_002475170.1	COG:S;COG3422
YP_002475179.1	COG:L;COG3723
YP_002475181.1	COG:L;COG0629
YP_002475188.1	COG:S;COG4733
YP_002475189.1	COG:K;COG3617
YP_002475191.1	COG:S;COG4723
YP_002475193.1	COG:S;COG4672
YP_002475194.1	COG:S;COG4718
YP_002475198.1	COG:S;COG3041
YP_002475199.1	COG:L;COG3077
YP_002475206.1	COG:S;COG5471
YP_002475208.1	COG:R;COG5511
YP_002475210.1	COG:R;COG5525
YP_002475211.1	similar to protein encoded by prophage CP-933K
YP_002475214.1	COG:R;COG3772
YP_002475227.1	COG:K;COG2932
YP_002475230.1	COG:L;COG0338
YP_002475231.1	COG:K;COG3636
YP_002475233.1	COG:S;COG3422
YP_002475240.1	hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP
YP_002475241.1	COG:M;COG2951
YP_002475242.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_002475243.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_002475246.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_002475247.1	COG:G;COG0058
YP_002475248.1	COG:R;COG1279
YP_002475249.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_002475251.1	COG:C;COG0508
YP_002475252.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_002475253.1	COG:C;COG0074
YP_002475254.1	COG:P;COG0475
YP_002475255.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002475256.1	COG:S;COG2852
YP_002475257.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_002475258.1	COG:R;COG3106
YP_002475259.1	COG:HC;COG0654
YP_002475260.1	COG:E;COG0709
YP_002475261.1	COG:S;COG3036
YP_002475263.1	COG:QR;COG0500
YP_002475264.1	COG:R;COG0628
YP_002475265.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_002475266.1	required for the formation of active formate dehydrogenase
YP_002475267.1	COG:M;COG1368
YP_002475268.1	COG:R;COG3217
YP_002475269.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_002475270.1	COG:H;COG0142
YP_002475272.1	COG:I;COG1250
YP_002475273.1	COG:I;COG0183
YP_002475274.1	COG:S;COG1556
YP_002475275.1	COG:C;COG1139
YP_002475276.1	COG:C;COG0247
YP_002475277.1	COG:C;COG1620
YP_002475278.1	COG:H;COG0262
YP_002475279.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_002475280.1	COG:R;COG0730
YP_002475281.1	COG:L;COG0177
YP_002475282.1	COG:T;COG3103
YP_002475283.1	COG:P;COG0306
YP_002475284.1	COG:P;COG1392
YP_002475285.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_002475286.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_002475287.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_002475288.1	COG:M;COG0791
YP_002475289.1	COG:F;COG0572
YP_002475290.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_002475291.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_002475292.1	COG:R;COG1286
YP_002475294.1	COG:S;COG1496
YP_002475295.1	COG:J;COG0251
YP_002475296.1	COG:S;COG4453
YP_002475297.1	COG:KR;COG0454
YP_002475298.1	COG:R;COG3081
YP_002475299.1	possibly involved in in maintaining the structural integrity of the cell envelope; COG:J;COG2913
YP_002475300.1	catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_002475301.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_002475302.1	COG:S;COG3098
YP_002475303.1	catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp
YP_002475304.1	COG:S;COG3140
YP_002475306.1	COG:S;COG2914
YP_002475307.1	COG:I;COG2867
YP_002475308.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_002475309.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_002475310.1	COG:D;COG2919
YP_002475311.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_002475312.1	COG:S;COG3025
YP_002475313.1	COG:T;COG3073
YP_002475314.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_002475316.1	COG:V;COG0286
YP_002475317.1	COG:V;COG0732
YP_002475318.1	COG:V;COG0610
YP_002475319.1	Transfers the fatty acyl group on membrane lipoproteins
YP_002475320.1	COG:P;COG4535
YP_002475321.1	COG:S;COG3110
YP_002475322.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_002475325.1	COG:TK;COG0317
YP_002475326.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_002475327.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_002475328.1	catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose
YP_002475329.1	COG:O;COG0760
YP_002475330.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_002475331.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_002475332.1	COG:K;COG5007
YP_002475333.1	COG:R;COG3113
YP_002475334.1	COG:Q;COG2854
YP_002475335.1	COG:Q;COG1463
YP_002475336.1	COG:Q;COG0767
YP_002475337.1	COG:Q;COG1127
YP_002475338.1	COG:R;COG2823
YP_002475339.1	COG:G;COG0279
YP_002475340.1	distantly related to archaeal holliday junction resolvase; COG:L;COG0792
YP_002475341.1	COG:R;COG3107
YP_002475342.1	COG:R;COG0313
YP_002475343.1	COG:P;COG0783
YP_002475344.1	COG:S;COG1801
YP_002475346.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_002475347.1	Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor
YP_002475348.1	COG:P;COG2032
YP_002475349.1	COG:M;COG4591
YP_002475350.1	COG:S;COG2364
YP_002475352.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_002475353.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_002475354.1	COG:NU;COG3121
YP_002475356.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_002475359.1	COG:S;COG3514
YP_002475360.1	COG:S;COG2929
YP_002475361.1	COG:L;COG5519
YP_002475366.1	COG:K;COG3311
YP_002475368.1	COG:L;COG0582
YP_002475369.1	catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway
YP_002475370.1	COG:KG;COG1349
YP_002475371.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_002475372.1	COG:S;COG2912
YP_002475373.1	COG:J;COG2890
YP_002475375.1	COG:L;COG0270
YP_002475376.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_002475377.1	COG:L;COG0776
YP_002475378.1	COG:S;COG3068
YP_002475379.1	COG:H;COG0407
YP_002475380.1	COG:G;COG0676
YP_002475381.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_002475382.1	functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase
YP_002475383.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component
YP_002475384.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component
YP_002475385.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_002475386.1	COG:S;COG2976
YP_002475387.1	COG:E;COG0345
YP_002475388.1	putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters
YP_002475389.1	COG:R;COG2961
YP_002475390.1	COG:V;COG3023
YP_002475391.1	COG:S;COG2431
YP_002475392.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_002475393.1	putative metalloprotease
YP_002475394.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_002475395.1	COG:I;COG0558
YP_002475396.1	part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE
YP_002475397.1	Part of the ABC transporter complex modABC involved in molybdenum import
YP_002475398.1	COG:P;COG0605
YP_002475402.1	COG:S;COG3680
YP_002475404.1	COG:K;COG1396
YP_002475405.1	COG:L;COG0582
YP_002475407.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_002475408.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_002475410.1	COG:J;COG1188
YP_002475411.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_002475412.1	COG:L;COG0847
YP_002475413.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_002475414.1	COG:L;COG1943
YP_002475415.1	COG:S;COG3759
YP_002475416.1	COG:S;COG4804
YP_002475417.1	COG:G;COG0363
YP_002475418.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_002475419.1	COG:P;COG1218
YP_002475420.1	COG:J;COG1186
YP_002475421.1	COG:QR;COG0500
YP_002475422.1	COG:L;COG5433
YP_002475423.1	COG:L;COG1555
YP_002475424.1	COG:M;COG3061
YP_002475426.1	COG:M;COG0859
YP_002475427.1	COG:I;COG1182
YP_002475428.1	COG:G;COG1109
YP_002475429.1	COG:J;COG0566
YP_002475430.1	COG:H;COG0142
YP_002475431.1	COG:S;COG1636
YP_002475432.1	COG:I;COG0331
YP_002475433.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_002475435.1	COG:E;COG1114
YP_002475436.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_002475437.1	COG:S;COG5566
YP_002475438.1	COG:S;COG4382
YP_002475441.1	COG:R;COG4396
YP_002475443.1	COG:U;COG3267
YP_002475454.1	COG:R;COG3926
YP_002475460.1	COG:R;COG4373
YP_002475469.1	COG:R;COG3497
YP_002475470.1	COG:R;COG3498
YP_002475479.1	COG:R;COG3500
YP_002475480.1	COG:R;COG4540
YP_002475481.1	COG:R;COG3628
YP_002475482.1	COG:R;COG3948
YP_002475489.1	involved in transport of zinc(II) with ZnuA and C
YP_002475490.1	catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome
YP_002475492.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_002475495.1	COG:H;COG0196
YP_002475496.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_002475500.1	COG:L;COG3547
YP_002475502.1	COG:R;COG4105
YP_002475503.1	responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA
YP_002475504.1	COG:T;COG0271
YP_002475505.1	COG:M;COG3056
YP_002475506.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_002475507.1	COG:K;COG1678
YP_002475508.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_002475509.1	dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate
YP_002475510.1	in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]
YP_002475511.1	COG:E;COG0747
YP_002475512.1	COG:EP;COG0601
YP_002475513.1	COG:EP;COG1173
YP_002475514.1	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF
YP_002475515.1	Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides
YP_002475516.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_002475518.1	COG:S;COG0217
YP_002475519.1	COG:LR;COG0494
YP_002475521.1	COG:H;COG0294
YP_002475522.1	COG:P;COG1393
YP_002475523.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_002475524.1	COG:S;COG3024
YP_002475525.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_002475526.1	COG:M;COG2980
YP_002475527.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_002475528.1	COG:K;COG1396
YP_002475529.1	catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002475531.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_002475532.1	functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose
YP_002475533.1	Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system
YP_002475534.1	COG:G;COG1925
YP_002475535.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_002475538.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_002475539.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_002475540.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_002475541.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_002475542.1	COG:R;COG3054
YP_002475543.1	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_002475544.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_002475545.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_002475546.1	COG:S;COG3101
YP_002475547.1	COG:C;COG0778
YP_002475548.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_002475549.1	COG:M;COG0859
YP_002475550.1	COG:S;COG3787
YP_002475551.1	COG:M;COG1088
YP_002475552.1	COG:R;COG1090
YP_002475553.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_002475554.1	oxidizes malate to oxaloacetate
YP_002475555.1	COG:O;COG3118
YP_002475556.1	COG:O;COG0492
YP_002475557.1	COG:M;COG0463
YP_002475558.1	COG:J;COG1534
YP_002475560.1	catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP
YP_002475561.1	COG:P;COG0475
YP_002475562.1	COG:L;COG2255
YP_002475563.1	COG:E;COG4166
YP_002475564.1	COG:EP;COG0601
YP_002475565.1	COG:EP;COG1173
YP_002475566.1	COG:R;COG4172
YP_002475567.1	Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
YP_002475568.1	COG:K;COG2909
YP_002475569.1	highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein
YP_002475570.1	COG:H;COG3071
YP_002475571.1	COG:H;COG2959
YP_002475572.1	COG:H;COG1587
YP_002475573.1	COG:H;COG0181
YP_002475574.1	COG:E;COG1115
YP_002475575.1	COG:G;COG1263
YP_002475576.1	COG:O;COG1025
YP_002475577.1	HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis
YP_002475578.1	COG:O;COG0466
YP_002475579.1	RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA
YP_002475580.1	hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_002475581.1	COG:KL;COG1199
YP_002475582.1	COG:F;COG0035
YP_002475583.1	participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate
YP_002475584.1	COG:M;COG0859
YP_002475587.1	COG:M;COG3306
YP_002475589.1	COG:M;COG0438
YP_002475590.1	COG:M;COG3306
YP_002475593.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_002475594.1	COG:L;COG5433
YP_002475595.1	lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_002475596.1	COG:L;COG0084
YP_002475598.1	COG:S;COG2908
YP_002475599.1	COG:M;COG0463
YP_002475600.1	COG:TK;COG0317
YP_002475602.1	promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_002475603.1	COG:G;COG0176
YP_002475604.1	COG:GEPR;COG0477
YP_002475605.1	COG:M;COG1087
YP_002475606.1	COG:J;COG1187
YP_002475607.1	COG:S;COG0718
YP_002475608.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_002475609.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_002475610.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_002475611.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_002475612.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_002475613.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_002475614.1	COG:O;COG1047
YP_002475616.1	COG:S;COG3471
YP_002475617.1	COG:S;COG1720
YP_002475618.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_002475619.1	COG:S;COG2835
YP_002475620.1	transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_002475621.1	COG:P;COG3721
YP_002475622.1	COG:P;COG0748
YP_002475623.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_002475624.1	COG:G;COG0580
YP_002475625.1	COG:M;COG1922
YP_002475626.1	enterobacterial common antigen polymerase
YP_002475627.1	catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis
YP_002475628.1	COG:M;COG0744
YP_002475629.1	with ArtPQJI acts to transport arginine across the inner membrane
YP_002475630.1	with ArtPMJI transports arginine across the inner membrane
YP_002475631.1	COG:ET;COG0834
YP_002475632.1	With ArtMQJI transports arginine across the inner membrane
YP_002475633.1	unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_002475634.1	COG:J;COG0359
YP_002475635.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_002475636.1	binds single-stranded DNA at the primosome assembly site
YP_002475637.1	COG:J;COG0360
YP_002475638.1	COG:GEPR;COG0477
YP_002475640.1	COG:R;COG5633
YP_002475641.1	COG:FGR;COG0537
YP_002475643.1	COG:L;COG5433
YP_002475644.1	may be involved in the utilization of double-stranded DNA as a carbon source; cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source
YP_002475645.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_002475646.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_002475647.1	COG:C;COG2869
YP_002475648.1	Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm
YP_002475649.1	COG:C;COG2209
YP_002475650.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_002475652.1	COG:R;COG1708
YP_002475653.1	permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine
YP_002475654.1	catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552
YP_002475655.1	part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia
YP_002475656.1	COG:C;COG0437
YP_002475657.1	COG:P;COG3301
YP_002475658.1	COG:M;COG3774
YP_002475659.1	COG:R;COG3726
YP_002475660.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_002475661.1	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_002475662.1	COG:P;COG0803
YP_002475663.1	COG:P;COG1121
YP_002475664.1	COG:P;COG1108
YP_002475665.1	COG:P;COG1108
YP_002475666.1	COG:S;COG4316
YP_002475667.1	COG:K;COG1396
YP_002475668.1	COG:G;COG1621
YP_002475669.1	COG:P;COG2824
YP_002475670.1	COG:F;COG0299
YP_002475671.1	catalyzes the formation of fumarate from aspartate
YP_002475673.1	molecular chaperone
YP_002475674.1	COG:M;COG2027
YP_002475675.1	COG:K;COG0782
YP_002475676.1	COG:E;COG4608
YP_002475678.1	COG:EP;COG0601
YP_002475679.1	COG:E;COG0747
YP_002475680.1	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_002475681.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_002475682.1	COG:R;COG2916
YP_002475683.1	COG:C;COG1757
YP_002475684.1	COG:O;COG1138
YP_002475685.1	COG:OC;COG0526
YP_002475686.1	COG:O;COG3088
YP_002475687.1	COG:O;COG4235
YP_002475688.1	COG:E;COG3842
YP_002475689.1	COG:P;COG1178
YP_002475690.1	COG:P;COG1840
YP_002475691.1	COG:P;COG1858
YP_002475692.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_002475693.1	COG:P;COG0025
YP_002475694.1	COG:O;COG0760
YP_002475695.1	COG:H;COG1985
YP_002475696.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_002475697.1	COG:H;COG0108
YP_002475698.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_002475699.1	COG:R;COG1101
YP_002475700.1	COG:R;COG4120
YP_002475704.1	YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function
YP_002475705.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_002475706.1	COG:L;COG0582
YP_002475708.1	COG:L;COG5433
YP_002475709.1	COG:S;COG5346
YP_002475711.1	COG:S;COG3692
YP_002475721.1	COG:H;COG0212
YP_002475722.1	COG:S;COG3027
YP_002475723.1	COG:S;COG3079
YP_002475724.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_002475726.1	catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis
YP_002475727.1	COG:S;COG1322
YP_002475728.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_002475729.1	COG:T;COG0664
YP_002475730.1	COG:R;COG0641
YP_002475731.1	transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA
YP_002475732.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_002475733.1	COG:S;COG2960
YP_002475734.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_002475735.1	COG:J;COG0009
YP_002475736.1	COG:L;COG0551
YP_002475737.1	COG:S;COG3097
YP_002475738.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_002475739.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_002475740.1	COG:EH;COG0115
YP_002475741.1	catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine
YP_002475743.1	with TehA confers resistance to tellurite
YP_002475744.1	COG:J;COG0042
YP_002475745.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_002475746.1	synthesizes RNA primers at the replication forks
YP_002475747.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_002475749.1	COG:J;COG1530
YP_002475750.1	COG:M;COG0773
YP_002475751.1	catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate
YP_002475753.1	COG:E;COG0747
YP_002475754.1	COG:K;COG1609
YP_002475755.1	COG:KE;COG3283
YP_002475756.1	COG:E;COG4166
YP_002475757.1	COG:V;COG4168
YP_002475758.1	catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine
YP_002475759.1	COG:OC;COG0526
YP_002475760.1	COG:O;COG3088
YP_002475761.1	COG:O;COG4235
YP_002475762.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_002475763.1	COG:R;COG1923
YP_002475764.1	COG:R;COG2262
YP_002475765.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_002475766.1	catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein
YP_002475767.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_002475768.1	COG:Q;COG2313
YP_002475769.1	COG:G;COG0524
YP_002475770.1	COG:F;COG1972
YP_002475771.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_002475772.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_002475773.1	COG:S;COG3102
YP_002475774.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_002475775.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_002475777.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_002475778.1	COG:R;COG4123
YP_002475779.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_002475780.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_002475781.1	COG:S;COG2921
YP_002475782.1	COG:M;COG1686
YP_002475783.1	COG:M;COG0797
YP_002475784.1	COG:D;COG0772
YP_002475785.1	COG:M;COG0768
YP_002475786.1	COG:S;COG1576
YP_002475787.1	COG:S;COG0799
YP_002475788.1	Regulatory factor involved in maltose metabolism
YP_002475789.1	heat shock protein involved in degradation of misfolded proteins
YP_002475790.1	heat shock protein involved in degradation of misfolded proteins
YP_002475791.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_002475792.1	catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA
YP_002475794.1	COG:T;COG1702
YP_002475795.1	COG:H;COG4143
YP_002475796.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_002475797.1	COG:R;COG2962
YP_002475798.1	COG:R;COG2962
YP_002475799.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_002475800.1	COG:HQ;COG1169
YP_002475801.1	COG:I;COG0671
YP_002475802.1	catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine
YP_002475803.1	COG:R;COG0491
YP_002475804.1	COG:I;COG0020
YP_002475805.1	COG:I;COG0575
YP_002475806.1	COG:M;COG0750
YP_002475807.1	COG:M;COG4775
YP_002475808.1	COG:M;COG2825
YP_002475809.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_002475810.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_002475811.1	COG:M;COG1043
YP_002475812.1	multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_002475813.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_002475814.1	catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis
YP_002475815.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_002475816.1	COG:M;COG0859
YP_002475817.1	COG:P;COG2920
YP_002475818.1	COG:E;COG1115
YP_002475819.1	COG:R;COG2215
YP_002475820.1	COG:R;COG3683
YP_002475821.1	COG:E;COG0339
YP_002475822.1	COG:E;COG0077
YP_002475823.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_002475824.1	stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit
YP_002475825.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_002475826.1	COG:I;COG0511
YP_002475828.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_002475829.1	COG:H;COG0502
YP_002475830.1	COG:E;COG2171
YP_002475832.1	COG:R;COG1399
YP_002475833.1	COG:J;COG0333
YP_002475834.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_002475835.1	COG:E;COG0160
YP_002475836.1	COG:E;COG0076
YP_002475837.1	catalyzes the phosphorylation of NAD to NADP
YP_002475838.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_002475839.1	COG:S;COG1561
YP_002475840.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_002475841.1	COG:H;COG0340
YP_002475842.1	COG:S;COG2832
YP_002475843.1	forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis
YP_002475844.1	COG:E;COG0347
YP_002475845.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_002475846.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_002475847.1	COG:S;COG2938
YP_002475848.1	COG:L;COG1194
YP_002475849.1	COG:CO;COG2924
YP_002475850.1	Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_002475852.1	anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate
YP_002475853.1	sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters
YP_002475854.1	anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor
YP_002475855.1	catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA
YP_002475856.1	COG:M;COG0668
YP_002475857.1	COG:O;COG0501
YP_002475858.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_002475859.1	COG:KL;COG0553
YP_002475860.1	COG:S;COG3177
YP_002475862.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_002475867.1	COG:ER;COG0591
YP_002475868.1	proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain
YP_002475870.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_002475872.1	COG:E;COG0687
YP_002475873.1	COG:S;COG1584
YP_002475874.1	COG:L;COG0632
YP_002475875.1	COG:S;COG3091
YP_002475876.1	COG:J;COG3719
YP_002475877.1	COG:E;COG0031
YP_002475878.1	COG:R;COG0728
YP_002475879.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_002475881.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_002475882.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_002475883.1	COG:L;COG0497
YP_002475885.1	COG:L;COG3676
YP_002475886.1	MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair
YP_002475888.1	COG:P;COG0861
YP_002475889.1	COG:H;COG3840
YP_002475890.1	COG:D;COG3087
YP_002475891.1	COG:S;COG4390
YP_002475893.1	COG:U;COG0848
YP_002475894.1	COG:U;COG0811
YP_002475895.1	COG:P;COG0607
YP_002475896.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_002475897.1	COG:J;COG0042
YP_002475898.1	Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription
YP_002475899.1	COG:H;COG2226
YP_002475900.1	similar to unknown protein YigP of Escherichia coli, SCP-2 sterol transfer family containing domain involved in binding sterols; COG:S;COG3165
YP_002475901.1	COG:R;COG0661
YP_002475902.1	COG:D;COG0037
YP_002475903.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_002475904.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease
YP_002475907.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_002475908.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_002475910.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_002475911.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_002475913.1	COG:O;COG0602
YP_002475914.1	COG:H;COG0720
YP_002475915.1	COG:R;COG0603
YP_002475916.1	COG:R;COG1741
YP_002475917.1	catalyzes the removal of an N-terminal amino acid from a peptide or arylamide
YP_002475918.1	COG:K;COG1959
YP_002475919.1	COG:U;COG0805
YP_002475920.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_002475921.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_002475922.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_002475923.1	COG:QR;COG0500
YP_002475925.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_002475927.1	COG:LR;COG0494
YP_002475928.1	COG:S;COG3223
YP_002475929.1	COG:H;COG2091
YP_002475930.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_002475931.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_002475932.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_002475933.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_002475934.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_002475937.1	COG:R;COG0795
YP_002475938.1	COG:R;COG0795
YP_002475939.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_002475940.1	COG:O;COG0826
YP_002475941.1	COG:O;COG3590
YP_002475942.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_002475943.1	COG:I;COG1182
YP_002475945.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_002475946.1	COG:K;COG0202
YP_002475947.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_002475948.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_002475949.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_002475950.1	COG:J;COG0257
YP_002475951.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_002475952.1	late assembly protein
YP_002475953.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_002475954.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_002475955.1	binds 5S rRNA along with protein L5 and L25
YP_002475956.1	COG:J;COG0097
YP_002475957.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_002475958.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_002475959.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_002475960.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_002475961.1	COG:J;COG0093
YP_002475964.1	COG:M;COG1876
YP_002475965.1	COG:R;COG1123
YP_002475966.1	COG:EP;COG1173
YP_002475967.1	COG:EP;COG0601
YP_002475968.1	COG:E;COG0747
YP_002475969.1	COG:R;COG2005
YP_002475970.1	COG:P;COG0725
YP_002475972.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_002475974.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_002475975.1	COG:S;COG1738
YP_002475976.1	COG:E;COG2195
YP_002475977.1	catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively
YP_002475978.1	COG:L;COG3547
YP_002475979.1	COG:S;COG4947
YP_002475980.1	COG:E;COG0019
YP_002475981.1	COG:E;COG0814
YP_002475982.1	This protein performs the mismatch recognition step during the DNA repair process
YP_002475984.1	COG:O;COG0265
YP_002475985.1	COG:T;COG1966
YP_002475986.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_002475987.1	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_002475988.1	COG:P;COG0607
YP_002475989.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_002475992.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_002475993.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_002475994.1	COG:KG;COG1349
YP_002475995.1	COG:E;COG1687
YP_002475997.1	COG:S;COG3111
YP_002475998.1	catalyzes branch migration in Holliday junction intermediates
YP_002475999.1	COG:S;COG2850
YP_002476000.1	COG:S;COG4285
YP_002476001.1	COG:R;COG1268
YP_002476002.1	COG:R;COG0561
YP_002476003.1	COG:R;COG1040
YP_002476004.1	COG:L;COG0084
YP_002476005.1	COG:K;COG0557
YP_002476006.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters
YP_002476007.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_002476008.1	binds the polymerase to DNA and acts as a sliding clamp
YP_002476009.1	COG:S;COG0762
YP_002476010.1	COG:S;COG1872
YP_002476011.1	COG:R;COG4137
YP_002476012.1	COG:P;COG4536
YP_002476013.1	COG:U;COG0541
YP_002476014.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_002476016.1	catalyzes the O-acetylation of serine
YP_002476017.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_002476018.1	COG:TK;COG0745
YP_002476019.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_002476020.1	COG:H;COG1539
YP_002476021.1	COG:S;COG0344
YP_002476022.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_002476024.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_002476026.1	COG:KG;COG1349
YP_002476027.1	COG:S;COG4380
YP_002476028.1	COG:S;COG4259
YP_002476029.1	COG:M;COG1462
YP_002476030.1	catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose
YP_002476031.1	COG:G;COG1070
YP_002476032.1	COG:G;COG4154
YP_002476033.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_002476034.1	COG:K;COG1737
YP_002476035.1	COG:G;COG0524
YP_002476036.1	COG:E;COG3962
YP_002476037.1	COG:G;COG1082
YP_002476038.1	COG:R;COG0673
YP_002476039.1	COG:G;COG1455
YP_002476040.1	COG:G;COG3669
YP_002476041.1	COG:R;COG0673
YP_002476042.1	COG:G;COG1172
YP_002476043.1	COG:G;COG1129
YP_002476044.1	COG:G;COG1879
YP_002476045.1	COG:C;COG1012
YP_002476046.1	COG:G;COG3718
YP_002476047.1	COG:P;COG2168
YP_002476048.1	COG:P;COG2923
YP_002476049.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_002476050.1	COG:S;COG2964
YP_002476051.1	COG:O;COG0545
YP_002476052.1	COG:S;COG2900
YP_002476053.1	COG:OC;COG0526
YP_002476054.1	COG:F;COG0775
YP_002476055.1	catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit
YP_002476056.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_002476057.1	COG:O;COG4545
YP_002476059.1	COG:S;COG2852
YP_002476061.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_002476062.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_002476063.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_002476064.1	COG:S;COG2830
YP_002476065.1	COG:QR;COG0500
YP_002476066.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_002476068.1	COG:L;COG4973
YP_002476069.1	binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_002476070.1	COG:P;COG1629
YP_002476071.1	COG:S;COG3016
YP_002476072.1	with HmuTU is involved in the transport of hemin
YP_002476073.1	COG:P;COG0609
YP_002476074.1	COG:P;COG4558
YP_002476075.1	COG:LU;COG0758
YP_002476076.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_002476077.1	catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose
YP_002476080.1	COG:K;COG1396
YP_002476081.1	COG:JD;COG2026
YP_002476082.1	COG:L;COG5519
YP_002476087.1	COG:L;COG0582
YP_002476088.1	catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis
YP_002476089.1	COG:J;COG3276
YP_002476090.1	COG:K;COG1396
YP_002476091.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_002476093.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_002476094.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_002476095.1	COG:S;COG3171
YP_002476096.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_002476097.1	COG:I;COG0332
YP_002476098.1	COG:L;COG3547
YP_002476099.1	COG:L;COG3547
YP_002476101.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_002476104.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_002476105.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_002476106.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_002476107.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_002476108.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_002476109.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_002476110.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_002476111.1	COG:J;COG0092
YP_002476112.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_002476113.1	one of the stabilizing components for the large ribosomal subunit
YP_002476114.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_002476115.1	COG:G;COG4409
YP_002476116.1	COG:P;COG0471
YP_002476117.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
YP_002476118.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_002476119.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_002476120.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_002476121.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_002476122.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_002476123.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_002476124.1	COG:C;COG0055
YP_002476125.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_002476126.1	COG:K;COG1609
YP_002476127.1	cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source
YP_002476128.1	with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain
YP_002476129.1	functions to transport ribose at high affinity; forms a complex with RbsA2C2B
YP_002476130.1	periplasmic substrate-binding component of the ATP-dependent ribose transport system
YP_002476131.1	catalyzes the formation of D-ribose 5-phosphate from ribose
YP_002476132.1	COG:E;COG0174
YP_002476134.1	COG:R;COG0300
YP_002476136.1	COG:S;COG4922
YP_002476137.1	COG:K;COG0583
YP_002476138.1	COG:L;COG1074
YP_002476139.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_002476140.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_002476142.1	COG:S;COG2707
YP_002476143.1	involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
YP_002476144.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_002476145.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_002476146.1	COG:O;COG0330
YP_002476147.1	COG:OU;COG1585
YP_002476148.1	COG:F;COG2233
YP_002476149.1	COG:R;COG2252
YP_002476150.1	COG:R;COG4221
YP_002476151.1	COG:P;COG0288
YP_002476152.1	COG:L;COG3547
YP_002476153.1	COG:V;COG1136
YP_002476154.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_002476155.1	COG:FR;COG0402
YP_002476156.1	COG:H;COG1179
YP_002476157.1	COG:C;COG1252
YP_002476158.1	COG:QR;COG0500
YP_002476159.1	Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_002476160.1	in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase
YP_002476161.1	COG:L;COG1943
YP_002476162.1	part of membrane-bound complex hought to be involved in electron transport to nitrogen
YP_002476163.1	RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents
YP_002476164.1	COG:S;COG2860
YP_002476165.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_002476166.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_002476167.1	COG:C;COG4657
YP_002476169.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_002476170.1	COG:L;COG3547
YP_002476171.1	COG:L;COG2963
YP_002476172.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_002476173.1	carries the fatty acid chain in fatty acid biosynthesis
YP_002476174.1	phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least
YP_002476175.1	COG:P;COG3142
YP_002476176.1	COG:G;COG2017
YP_002476177.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_002476178.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_002476179.1	COG:I;COG1022
YP_002476180.1	COG:R;COG3381
YP_002476181.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_002476182.1	binds directly to 23S ribosomal RNA
YP_002476183.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_002476184.1	COG:S;COG2259
YP_002476186.1	COG:V;COG0286
YP_002476189.1	COG:V;COG0610
YP_002476191.1	COG:K;COG1733
YP_002476193.1	COG:G;COG1879
YP_002476194.1	COG:G;COG1172
YP_002476195.1	COG:G;COG1129
YP_002476196.1	COG:G;COG1482
YP_002476197.1	COG:S;COG4811
YP_002476198.1	hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel
YP_002476199.1	COG:G;COG3715
YP_002476200.1	COG:G;COG3444
YP_002476201.1	COG:H;COG0276
YP_002476202.1	COG:L;COG1330
YP_002476203.1	COG:HC;COG0654
YP_002476205.1	COG:S;COG3657
YP_002476206.1	COG:K;COG3636
YP_002476207.1	COG:S;COG4226
YP_002476208.1	COG:O;COG0606
YP_002476209.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_002476210.1	COG:F;COG0125
YP_002476211.1	COG:R;COG1559
YP_002476212.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_002476213.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_002476214.1	COG:S;COG1238
YP_002476216.1	COG:M;COG0739
YP_002476217.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_002476218.1	COG:S;COG2995
YP_002476219.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_002476220.1	COG:R;COG0354
YP_002476221.1	COG:K;COG1846
YP_002476224.1	COG:R;COG3943
YP_002476225.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_002476226.1	COG:M;COG0472
YP_002476228.1	COG:M;COG0381
YP_002476229.1	COG:M;COG0677
YP_002476230.1	two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_002476231.1	related to short-chain alcohol dehydrogenases; COG:IQR;COG1028
YP_002476232.1	COG:L;COG2826
YP_002476233.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_002476236.1	COG:E;COG0757
YP_002476237.1	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization
YP_002476238.1	COG:GT;COG1762
YP_002476239.1	COG:S;COG3037
YP_002476240.1	L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate
YP_002476241.1	COG:G;COG0235
YP_002476243.1	COG:R;COG1611
YP_002476244.1	COG:R;COG1694
YP_002476245.1	COG:GE;COG2610
YP_002476246.1	COG:G;COG3265
YP_002476247.1	COG:K;COG1609
YP_002476248.1	COG:C;COG3005
YP_002476249.1	COG:C;COG3043
YP_002476250.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA
YP_002476251.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway
YP_002476252.1	periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC
YP_002476253.1	COG:P;COG3062
YP_002476254.1	COG:C;COG1145
YP_002476256.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif
YP_002476257.1	RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_002476258.1	COG:G;COG0036
YP_002476259.1	COG:P;COG3119
YP_002476260.1	uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function
YP_002476261.1	COG:R;COG0730
YP_002476262.1	Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA
YP_002476263.1	negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis
YP_002476264.1	COG:OC;COG0526
YP_002476265.1	COG:OC;COG0526
YP_002476266.1	COG:S;COG3084
YP_002476267.1	in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; MobB is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway
YP_002476268.1	COG:K;COG1414
YP_002476270.1	COG:G;COG1070
YP_002476271.1	COG:K;COG0250
YP_002476272.1	forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_002476273.1	COG:R;COG0312
YP_002476275.1	COG:R;COG2819
YP_002476276.1	COG:K;COG1396
YP_002476277.1	COG:R;COG3550
YP_002476278.1	COG:O;COG3531
YP_002476279.1	COG:K;COG0583
YP_002476280.1	COG:V;COG3587
YP_002476281.1	COG:L;COG2189
YP_002476282.1	COG:R;COG1373
YP_002476284.1	COG:K;COG0789
YP_002476285.1	COG:P;COG1230
YP_002476286.1	COG:K;COG0789
YP_002476288.1	COG:S;COG3544
YP_002476289.1	COG:R;COG2070
YP_002476291.1	COG:S;COG4804
YP_002476292.1	COG:H;COG0352
YP_002476293.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_002476294.1	COG:H;COG2145
YP_002476295.1	COG:R;COG0312
YP_002476297.1	COG:R;COG2819
YP_002476298.1	COG:K;COG1396
YP_002476299.1	COG:R;COG3550
YP_002476301.1	COG:S;COG4922
YP_002476302.1	COG:L;COG0742
YP_002476303.1	COG:U;COG0552
YP_002476304.1	COG:D;COG2884
YP_002476306.1	COG:O;COG0625
YP_002476307.1	COG:R;COG3545
YP_002476308.1	COG:KG;COG1349
YP_002476309.1	COG:I;COG2084
YP_002476310.1	COG:S;COG3395
YP_002476311.1	COG:G;COG0235
YP_002476312.1	COG:G;COG3622
YP_002476313.1	COG:MG;COG0451
YP_002476314.1	COG:GE;COG2610
YP_002476315.1	COG:R;COG4099
YP_002476317.1	component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent
YP_002476318.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_002476319.1	COG:H;COG3161
YP_002476320.1	COG:E;COG2755
YP_002476321.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002476322.1	COG:H;COG0043
YP_002476323.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_002476324.1	COG:S;COG3309
YP_002476326.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_002476327.1	COG:P;COG0387
YP_002476328.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_002476329.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_002476330.1	exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
YP_002476331.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_002476332.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_002476333.1	COG:S;COG0759
YP_002476334.1	COG:S;COG1739
YP_002476335.1	COG:R;COG2358
YP_002476336.1	COG:R;COG4666
YP_002476337.1	COG:T;COG0589
YP_002476338.1	COG:R;COG1669
YP_002476339.1	COG:S;COG4804
YP_002476340.1	COG:K;COG1396
YP_002476344.1	COG:R;COG1487
YP_002476346.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_002476347.1	COG:J;COG0144
YP_002476348.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_002476349.1	COG:E;COG0686
YP_002476350.1	COG:R;COG0733
YP_002476354.1	COG:L;COG0270
YP_002476355.1	COG:L;COG0270
YP_002476360.1	COG:P;COG0168
YP_002476361.1	COG:R;COG0561
YP_002476362.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_002476363.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_002476364.1	COG:J;COG0292
YP_002476365.1	COG:J;COG0291
YP_002476366.1	COG:J;COG0290
YP_002476367.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_002476368.1	catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_002476369.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_002476372.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_002476373.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_002476374.1	Essential for efficient processing of 16S rRNA
YP_002476375.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_002476377.1	COG:C;COG1757
YP_002476383.1	COG:R;COG1451
YP_002476384.1	similar to modification methylase EcoRI (adenine-specificmethyltransferase EcoRI) (M.EcoRI)
YP_002476387.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_002476388.1	transcriptional repressor of asnA which codes for aspartate-ammonia ligase
YP_002476389.1	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway
YP_002476390.1	COG:S;COG3085
YP_002476391.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_002476392.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_002476393.1	COG:J;COG0049
YP_002476394.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_002476395.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_002476396.1	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
YP_002476397.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_002476398.1	COG:T;COG0639
YP_002476399.1	catalyzes the formation of NAD(+) from nicotinamide ribonucleotide
YP_002476400.1	COG:C;COG1145
YP_002476401.1	COG:CH;COG4635
YP_002476402.1	Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity
YP_002476403.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_002476406.1	COG:S;COG2990
YP_002476407.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_002476408.1	COG:L;COG0863
YP_002476410.1	COG:S;COG3177
YP_002476412.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_002476413.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_002476414.1	monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate
YP_002476415.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_002476416.1	TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity
YP_002476417.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_002476418.1	COG:M;COG1368
YP_002476419.1	COG:J;COG1187
YP_002476420.1	COG:J;COG0009
YP_002476421.1	COG:R;COG2166
YP_002476422.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_002476423.1	binds and unfolds substrates as part of the ClpXP protease
YP_002476424.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_002476426.1	COG:NU;COG1459
YP_002476427.1	COG:NU;COG2804
YP_002476428.1	COG:S;COG2852
YP_002476429.1	COG:NU;COG4969
YP_002476430.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_002476431.1	Essential for recycling GMP and indirectly, cGMP
YP_002476432.1	COG:L;COG3547
YP_002476434.1	COG:L;COG0210
YP_002476436.1	COG:J;COG0219
YP_002476437.1	catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA
YP_002476438.1	16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit
YP_002476439.1	with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_002476440.1	COG:M;COG0739
YP_002476441.1	alanine acetyltransferase that specifically acetylates ribosomal protein S18
YP_002476442.1	COG:R;COG3550
YP_002476443.1	COG:K;COG1396
YP_002476444.1	facilitates an early step in the assembly of the 50S subunit of the ribosome
YP_002476445.1	Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_002476446.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_002476447.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_002476448.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_002476451.1	complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons
YP_002476452.1	COG:S;COG3089
YP_002476453.1	FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly
YP_002476454.1	catalyzes the formation of dUMP from dUTP
YP_002476456.1	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_002476457.1	COG:L;COG2003
YP_002476458.1	required for 70S ribosome assembly
YP_002476459.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_002476460.1	COG:S;COG3111
YP_002476461.1	COG:TK;COG0745
YP_002476462.1	COG:T;COG0642
YP_002476464.1	COG:O;COG0234
YP_002476465.1	COG:O;COG0459
YP_002476466.1	catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P
YP_002476467.1	COG:L;COG2963
YP_002476468.1	COG:L;COG2801
YP_002476470.1	COG:S;COG0316
YP_002476471.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_002476472.1	COG:GER;COG0697
YP_002476473.1	COG:GER;COG0697
YP_002476474.1	involved in the peptidyltransferase reaction during translation
YP_002476475.1	COG:J;COG0261
YP_002476476.1	COG:G;COG1820
YP_002476477.1	catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate
YP_002476478.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_002476479.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_002476480.1	mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase
YP_002476481.1	COG:S;COG3924
YP_002476482.1	when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis
YP_002476483.1	responsible for the influx of magnesium ions
YP_002476484.1	COG:LK;COG1197
YP_002476486.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_002476487.1	COG:O;COG0545
YP_002476488.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_002476490.1	COG:I;COG0204
YP_002476491.1	COG:Q;COG2132
YP_002476492.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_002476493.1	COG:S;COG5566
YP_002476494.1	COG:G;COG1263
YP_002476495.1	COG:L;COG3547
YP_002476496.1	COG:ET;COG0834
YP_002476497.1	COG:E;COG0765
YP_002476498.1	COG:E;COG1126
YP_002476499.1	COG:S;COG1479
YP_002476500.1	COG:ER;COG0493
YP_002476501.1	COG:E;COG0069
YP_002476503.1	COG:L;COG3547
YP_002476504.1	COG:J;COG0251
YP_002476505.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_002476506.1	Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence
YP_002476507.1	manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily
YP_002476508.1	LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation
YP_002476510.1	COG:R;COG1409
YP_002476511.1	COG:CHR;COG1052
YP_002476513.1	COG:L;COG0270
YP_002476514.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_002476515.1	COG:S;COG1426
YP_002476516.1	COG:OU;COG0616
YP_002476517.1	COG:V;COG1132
YP_002476518.1	COG:H;COG3201
YP_002476519.1	controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP
YP_002476520.1	ATP-binding protein; required for proper cytochrome c maturation
YP_002476521.1	COG:O;COG2386
YP_002476522.1	COG:O;COG0755
YP_002476523.1	COG:U;COG3114
YP_002476524.1	COG:P;COG0471
YP_002476525.1	COG:G;COG0126
YP_002476527.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_002476528.1	COG:V;COG4167
YP_002476529.1	COG:C;COG0778
YP_002476530.1	COG:S;COG2862
YP_002476531.1	COG:E;COG0665
YP_002476532.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_002476533.1	COG:M;COG0794
YP_002476534.1	COG:NU;COG3063
YP_002476535.1	COG:L;COG3547
YP_002476536.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_002476537.1	COG:K;COG2944
YP_002476538.1	COG:JD;COG2026
YP_002476539.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_002476540.1	COG:P;COG2217
YP_002476541.1	COG:C;COG3783
YP_002476542.1	FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_002476543.1	COG:V;COG3587
YP_002476544.1	COG:L;COG2189
YP_002476546.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_002476547.1	COG:O;COG0330
YP_002476548.1	COG:O;COG0330
YP_002476549.1	COG:KR;COG0454
YP_002476550.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_002476552.1	COG:MU;COG1538
YP_002476553.1	Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A)
YP_002476554.1	COG:E;COG0346
YP_002476557.1	COG:K;COG2944
YP_002476559.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_002476560.1	COG:O;COG0278
YP_002476561.1	COG:L;COG0507
YP_002476562.1	COG:P;COG1629
YP_002476563.1	COG:U;COG2831
YP_002476564.1	COG:U;COG3210
YP_002476565.1	COG:G;COG0469
YP_002476566.1	COG:T;COG2062
YP_002476567.1	cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate
YP_002476568.1	COG:T;COG3851
YP_002476569.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_002476570.1	COG:E;COG0520
YP_002476571.1	COG:L;COG1525
YP_002476572.1	COG:K;COG0583
YP_002476573.1	catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters
YP_002476574.1	TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs
YP_002476576.1	COG:S;COG3076
YP_002476577.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_002476578.1	COG:S;COG3152
YP_002476579.1	COG:E;COG0308
YP_002476580.1	COG:R;COG0325
YP_002476581.1	COG:R;COG1778
YP_002476582.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_002476583.1	COG:R;COG0802
YP_002476584.1	COG:M;COG0860
YP_002476586.1	COG:S;COG1434
YP_002476587.1	COG:M;COG1083
YP_002476588.1	COG:M;COG0463
YP_002476589.1	COG:M;COG0463
YP_002476590.1	COG:O;COG1138
YP_002476591.1	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_002476592.1	catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme
YP_002476593.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_002476595.1	functions in MreBCD complex in some organisms
YP_002476596.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_002476597.1	COG:M;COG2891
YP_002476598.1	COG:L;COG2256
YP_002476601.1	COG:U;COG0811
YP_002476602.1	COG:U;COG0848
YP_002476604.1	COG:P;COG1629
YP_002476605.1	COG:J;COG1544
YP_002476607.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_002476608.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_002476609.1	COG:S;COG0393
YP_002476610.1	COG:S;COG2983
YP_002476611.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_002476612.1	COG:O;COG2844
YP_002476613.1	COG:V;COG4171
YP_002476614.1	COG:V;COG4170
YP_002476615.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_002476616.1	COG:S;COG1666
YP_002476617.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_002476618.1	COG:P;COG0753
YP_002476619.1	COG:R;COG1408
YP_002476620.1	COG:S;COG3120
YP_002476621.1	COG:O;COG1067
YP_002476622.1	catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP
YP_002476627.1	COG:V;COG0534
YP_002476628.1	COG:J;COG0564
YP_002476629.1	COG:P;COG3221
YP_002476630.1	COG:P;COG3638
YP_002476631.1	COG:P;COG3639
YP_002476632.1	COG:P;COG3639
YP_002476633.1	COG:S;COG2979
YP_002476634.1	hydrolyzes diadenosine polyphosphate
YP_002476635.1	COG:R;COG0730
YP_002476636.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_002476638.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_002476639.1	COG:P;COG0735
YP_002476640.1	COG:R;COG3008
YP_002476642.1	COG:L;COG3676
YP_002476643.1	affects solute and DNA transport through an unknown mechanism
YP_002476644.1	Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3
YP_002476645.1	COG:S;COG2989
YP_002476646.1	COG:S;COG3108
YP_002476647.1	COG:R;COG0491
YP_002476648.1	COG:M;COG2853
YP_002476649.1	COG:KT;COG1974
YP_002476650.1	catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity
YP_002476651.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_002476652.1	COG:E;COG0685
YP_002476653.1	COG:C;COG0538
YP_002476654.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_002476655.1	COG:C;COG0372
YP_002476656.1	COG:F;COG0563
YP_002476657.1	COG:R;COG0733
YP_002476658.1	COG:L;COG0338
YP_002476659.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_002476660.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_002476661.1	COG:M;COG5009
YP_002476666.1	COG:U;COG4796
YP_002476667.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_002476668.1	COG:H;COG0611
YP_002476669.1	COG:I;COG1267
YP_002476670.1	COG:E;COG1280
YP_002476671.1	COG:OC;COG0526
YP_002476672.1	COG:Q;COG2050
YP_002476673.1	COG:C;COG0277
YP_002476674.1	COG:M;COG2885
YP_002476675.1	this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress