-- dump date   	20140619_105402
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
228400000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
228400000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
228400000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400000004	Walker A motif; other site
228400000005	ATP binding site [chemical binding]; other site
228400000006	Walker B motif; other site
228400000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
228400000008	arginine finger; other site
228400000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
228400000010	DnaA box-binding interface [nucleotide binding]; other site
228400000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
228400000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
228400000013	putative DNA binding surface [nucleotide binding]; other site
228400000014	dimer interface [polypeptide binding]; other site
228400000015	beta-clamp/clamp loader binding surface; other site
228400000016	beta-clamp/translesion DNA polymerase binding surface; other site
228400000017	recF protein; Region: recf; TIGR00611
228400000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400000019	Walker A/P-loop; other site
228400000020	ATP binding site [chemical binding]; other site
228400000021	Q-loop/lid; other site
228400000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400000023	ABC transporter signature motif; other site
228400000024	Walker B; other site
228400000025	D-loop; other site
228400000026	H-loop/switch region; other site
228400000027	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
228400000028	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
228400000029	ligand binding site [chemical binding]; other site
228400000030	flexible hinge region; other site
228400000031	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
228400000032	putative switch regulator; other site
228400000033	non-specific DNA interactions [nucleotide binding]; other site
228400000034	DNA binding site [nucleotide binding]
228400000035	sequence specific DNA binding site [nucleotide binding]; other site
228400000036	putative cAMP binding site [chemical binding]; other site
228400000037	hypothetical protein; Provisional; Region: PRK04966
228400000038	division inhibitor protein; Provisional; Region: slmA; PRK09480
228400000039	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
228400000040	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
228400000041	trimer interface [polypeptide binding]; other site
228400000042	active site
228400000043	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
228400000044	Flavoprotein; Region: Flavoprotein; pfam02441
228400000045	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
228400000046	hypothetical protein; Reviewed; Region: PRK00024
228400000047	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
228400000048	MPN+ (JAMM) motif; other site
228400000049	Zinc-binding site [ion binding]; other site
228400000050	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
228400000051	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
228400000052	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
228400000053	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
228400000054	DNA binding site [nucleotide binding]
228400000055	catalytic residue [active]
228400000056	H2TH interface [polypeptide binding]; other site
228400000057	putative catalytic residues [active]
228400000058	turnover-facilitating residue; other site
228400000059	intercalation triad [nucleotide binding]; other site
228400000060	8OG recognition residue [nucleotide binding]; other site
228400000061	putative reading head residues; other site
228400000062	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
228400000063	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
228400000064	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
228400000065	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
228400000066	PYR/PP interface [polypeptide binding]; other site
228400000067	dimer interface [polypeptide binding]; other site
228400000068	TPP binding site [chemical binding]; other site
228400000069	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
228400000070	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
228400000071	TPP-binding site [chemical binding]; other site
228400000072	dimer interface [polypeptide binding]; other site
228400000073	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
228400000074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
228400000075	MOSC domain; Region: MOSC; pfam03473
228400000076	Chorismate lyase; Region: Chor_lyase; cl01230
228400000077	exoribonuclease R; Provisional; Region: PRK11642
228400000078	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
228400000079	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
228400000080	RNB domain; Region: RNB; pfam00773
228400000081	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
228400000082	RNA binding site [nucleotide binding]; other site
228400000083	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
228400000084	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
228400000085	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
228400000086	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
228400000087	Sel1-like repeats; Region: SEL1; smart00671
228400000088	serine acetyltransferase; Provisional; Region: cysE; PRK11132
228400000089	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
228400000090	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
228400000091	trimer interface [polypeptide binding]; other site
228400000092	active site
228400000093	substrate binding site [chemical binding]; other site
228400000094	CoA binding site [chemical binding]; other site
228400000095	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
228400000096	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
228400000097	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
228400000098	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
228400000099	SecA binding site; other site
228400000100	Preprotein binding site; other site
228400000101	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
228400000102	active site residue [active]
228400000103	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
228400000104	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
228400000105	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
228400000106	UbiA prenyltransferase family; Region: UbiA; pfam01040
228400000107	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
228400000108	active site residue [active]
228400000109	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
228400000110	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
228400000111	hypothetical protein; Provisional; Region: PRK11193
228400000112	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
228400000113	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
228400000114	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
228400000115	dimer interface [polypeptide binding]; other site
228400000116	active site
228400000117	CoA binding pocket [chemical binding]; other site
228400000118	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
228400000119	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
228400000120	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
228400000121	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
228400000122	NAD(P) binding site [chemical binding]; other site
228400000123	homotetramer interface [polypeptide binding]; other site
228400000124	homodimer interface [polypeptide binding]; other site
228400000125	active site
228400000126	acyl carrier protein; Provisional; Region: acpP; PRK00982
228400000127	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
228400000128	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
228400000129	23S rRNA interface [nucleotide binding]; other site
228400000130	L7/L12 interface [polypeptide binding]; other site
228400000131	putative thiostrepton binding site; other site
228400000132	L25 interface [polypeptide binding]; other site
228400000133	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
228400000134	mRNA/rRNA interface [nucleotide binding]; other site
228400000135	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
228400000136	23S rRNA interface [nucleotide binding]; other site
228400000137	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
228400000138	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
228400000139	core dimer interface [polypeptide binding]; other site
228400000140	peripheral dimer interface [polypeptide binding]; other site
228400000141	L10 interface [polypeptide binding]; other site
228400000142	L11 interface [polypeptide binding]; other site
228400000143	putative EF-Tu interaction site [polypeptide binding]; other site
228400000144	putative EF-G interaction site [polypeptide binding]; other site
228400000145	transcription termination factor Rho; Provisional; Region: rho; PRK09376
228400000146	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
228400000147	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
228400000148	RNA binding site [nucleotide binding]; other site
228400000149	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
228400000150	multimer interface [polypeptide binding]; other site
228400000151	Walker A motif; other site
228400000152	ATP binding site [chemical binding]; other site
228400000153	Walker B motif; other site
228400000154	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
228400000155	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
228400000156	ATP binding site [chemical binding]; other site
228400000157	Mg++ binding site [ion binding]; other site
228400000158	motif III; other site
228400000159	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400000160	nucleotide binding region [chemical binding]; other site
228400000161	ATP-binding site [chemical binding]; other site
228400000162	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
228400000163	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
228400000164	substrate binding site [chemical binding]; other site
228400000165	hexamer interface [polypeptide binding]; other site
228400000166	metal binding site [ion binding]; metal-binding site
228400000167	phosphoglycolate phosphatase; Provisional; Region: PRK13222
228400000168	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
228400000169	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400000170	motif II; other site
228400000171	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
228400000172	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
228400000173	active site
228400000174	HIGH motif; other site
228400000175	dimer interface [polypeptide binding]; other site
228400000176	KMSKS motif; other site
228400000177	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
228400000178	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400000179	motif II; other site
228400000180	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
228400000181	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
228400000182	UPF0126 domain; Region: UPF0126; pfam03458
228400000183	Predicted membrane protein [Function unknown]; Region: COG2860
228400000184	UPF0126 domain; Region: UPF0126; pfam03458
228400000185	threonine dehydratase; Reviewed; Region: PRK09224
228400000186	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
228400000187	tetramer interface [polypeptide binding]; other site
228400000188	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400000189	catalytic residue [active]
228400000190	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
228400000191	putative Ile/Val binding site [chemical binding]; other site
228400000192	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
228400000193	putative Ile/Val binding site [chemical binding]; other site
228400000194	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
228400000195	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
228400000196	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
228400000197	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
228400000198	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
228400000199	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
228400000200	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
228400000201	active site
228400000202	HIGH motif; other site
228400000203	nucleotide binding site [chemical binding]; other site
228400000204	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
228400000205	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
228400000206	active site
228400000207	KMSKS motif; other site
228400000208	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
228400000209	tRNA binding surface [nucleotide binding]; other site
228400000210	anticodon binding site; other site
228400000211	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
228400000212	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
228400000213	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
228400000214	active site
228400000215	Riboflavin kinase; Region: Flavokinase; smart00904
228400000216	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
228400000217	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
228400000218	folate binding site [chemical binding]; other site
228400000219	NADP+ binding site [chemical binding]; other site
228400000220	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
228400000221	Uncharacterized conserved protein [Function unknown]; Region: COG2966
228400000222	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
228400000223	gamma-glutamyl kinase; Provisional; Region: PRK05429
228400000224	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
228400000225	nucleotide binding site [chemical binding]; other site
228400000226	homotetrameric interface [polypeptide binding]; other site
228400000227	putative phosphate binding site [ion binding]; other site
228400000228	putative allosteric binding site; other site
228400000229	PUA domain; Region: PUA; pfam01472
228400000230	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
228400000231	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
228400000232	putative homodimer interface [polypeptide binding]; other site
228400000233	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
228400000234	heterodimer interface [polypeptide binding]; other site
228400000235	homodimer interface [polypeptide binding]; other site
228400000236	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
228400000237	elongation factor Tu; Reviewed; Region: PRK00049
228400000238	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
228400000239	G1 box; other site
228400000240	GEF interaction site [polypeptide binding]; other site
228400000241	GTP/Mg2+ binding site [chemical binding]; other site
228400000242	Switch I region; other site
228400000243	G2 box; other site
228400000244	G3 box; other site
228400000245	Switch II region; other site
228400000246	G4 box; other site
228400000247	G5 box; other site
228400000248	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
228400000249	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
228400000250	Antibiotic Binding Site [chemical binding]; other site
228400000251	pantothenate kinase; Provisional; Region: PRK05439
228400000252	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
228400000253	ATP-binding site [chemical binding]; other site
228400000254	CoA-binding site [chemical binding]; other site
228400000255	Mg2+-binding site [ion binding]; other site
228400000256	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
228400000257	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
228400000258	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
228400000259	putative active site [active]
228400000260	putative PHP Thumb interface [polypeptide binding]; other site
228400000261	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
228400000262	generic binding surface II; other site
228400000263	generic binding surface I; other site
228400000264	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
228400000265	Clp amino terminal domain; Region: Clp_N; pfam02861
228400000266	Clp amino terminal domain; Region: Clp_N; pfam02861
228400000267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400000268	Walker A motif; other site
228400000269	ATP binding site [chemical binding]; other site
228400000270	Walker B motif; other site
228400000271	arginine finger; other site
228400000272	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400000273	Walker A motif; other site
228400000274	ATP binding site [chemical binding]; other site
228400000275	Walker B motif; other site
228400000276	arginine finger; other site
228400000277	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
228400000278	Protein of unknown function, DUF606; Region: DUF606; pfam04657
228400000279	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
228400000280	oxaloacetate decarboxylase; Provisional; Region: PRK14040
228400000281	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
228400000282	active site
228400000283	catalytic residues [active]
228400000284	metal binding site [ion binding]; metal-binding site
228400000285	homodimer binding site [polypeptide binding]; other site
228400000286	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
228400000287	carboxyltransferase (CT) interaction site; other site
228400000288	biotinylation site [posttranslational modification]; other site
228400000289	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
228400000290	transaldolase-like protein; Provisional; Region: PTZ00411
228400000291	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
228400000292	active site
228400000293	dimer interface [polypeptide binding]; other site
228400000294	catalytic residue [active]
228400000295	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
228400000296	OstA-like protein; Region: OstA; pfam03968
228400000297	Organic solvent tolerance protein; Region: OstA_C; pfam04453
228400000298	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
228400000299	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
228400000300	active site
228400000301	intersubunit interface [polypeptide binding]; other site
228400000302	zinc binding site [ion binding]; other site
228400000303	Na+ binding site [ion binding]; other site
228400000304	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
228400000305	Phosphoglycerate kinase; Region: PGK; pfam00162
228400000306	substrate binding site [chemical binding]; other site
228400000307	hinge regions; other site
228400000308	ADP binding site [chemical binding]; other site
228400000309	catalytic site [active]
228400000310	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
228400000311	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400000312	trimer interface [polypeptide binding]; other site
228400000313	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400000314	trimer interface [polypeptide binding]; other site
228400000315	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400000316	trimer interface [polypeptide binding]; other site
228400000317	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400000318	trimer interface [polypeptide binding]; other site
228400000319	YadA-like C-terminal region; Region: YadA; pfam03895
228400000320	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
228400000321	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
228400000322	Walker A/P-loop; other site
228400000323	ATP binding site [chemical binding]; other site
228400000324	Q-loop/lid; other site
228400000325	ABC transporter signature motif; other site
228400000326	Walker B; other site
228400000327	D-loop; other site
228400000328	H-loop/switch region; other site
228400000329	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
228400000330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400000331	dimer interface [polypeptide binding]; other site
228400000332	conserved gate region; other site
228400000333	putative PBP binding loops; other site
228400000334	ABC-ATPase subunit interface; other site
228400000335	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
228400000336	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
228400000337	substrate binding pocket [chemical binding]; other site
228400000338	membrane-bound complex binding site; other site
228400000339	hinge residues; other site
228400000340	Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958
228400000341	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
228400000342	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
228400000343	transmembrane helices; other site
228400000344	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
228400000345	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
228400000346	UbiA prenyltransferase family; Region: UbiA; pfam01040
228400000347	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
228400000348	homodimer interaction site [polypeptide binding]; other site
228400000349	cofactor binding site; other site
228400000350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400000351	Walker A motif; other site
228400000352	ATP binding site [chemical binding]; other site
228400000353	Walker B motif; other site
228400000354	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
228400000355	D-ribose pyranase; Provisional; Region: PRK11797
228400000356	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
228400000357	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400000358	Walker A/P-loop; other site
228400000359	ATP binding site [chemical binding]; other site
228400000360	Q-loop/lid; other site
228400000361	ABC transporter signature motif; other site
228400000362	Walker B; other site
228400000363	D-loop; other site
228400000364	H-loop/switch region; other site
228400000365	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400000366	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400000367	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400000368	TM-ABC transporter signature motif; other site
228400000369	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
228400000370	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
228400000371	ligand binding site [chemical binding]; other site
228400000372	dimerization interface [polypeptide binding]; other site
228400000373	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
228400000374	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
228400000375	substrate binding site [chemical binding]; other site
228400000376	dimer interface [polypeptide binding]; other site
228400000377	ATP binding site [chemical binding]; other site
228400000378	transcriptional repressor RbsR; Provisional; Region: PRK10423
228400000379	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
228400000380	DNA binding site [nucleotide binding]
228400000381	domain linker motif; other site
228400000382	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
228400000383	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
228400000384	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
228400000385	nucleoid-associated protein NdpA; Validated; Region: PRK00378
228400000386	Nucleoid-associated protein [General function prediction only]; Region: COG3081
228400000387	hypothetical protein; Provisional; Region: PRK13689
228400000388	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
228400000389	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
228400000390	Sulfatase; Region: Sulfatase; cl17466
228400000391	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
228400000392	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
228400000393	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
228400000394	ligand binding site [chemical binding]; other site
228400000395	homodimer interface [polypeptide binding]; other site
228400000396	NAD(P) binding site [chemical binding]; other site
228400000397	trimer interface B [polypeptide binding]; other site
228400000398	trimer interface A [polypeptide binding]; other site
228400000399	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
228400000400	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
228400000401	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
228400000402	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
228400000403	Sulfatase; Region: Sulfatase; cl17466
228400000404	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400000405	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400000406	TM-ABC transporter signature motif; other site
228400000407	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400000408	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
228400000409	Walker A/P-loop; other site
228400000410	ATP binding site [chemical binding]; other site
228400000411	Q-loop/lid; other site
228400000412	ABC transporter signature motif; other site
228400000413	Walker B; other site
228400000414	D-loop; other site
228400000415	H-loop/switch region; other site
228400000416	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400000417	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
228400000418	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
228400000419	ligand binding site [chemical binding]; other site
228400000420	calcium binding site [ion binding]; other site
228400000421	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
228400000422	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
228400000423	dimer interface [polypeptide binding]; other site
228400000424	active site
228400000425	galactokinase; Provisional; Region: PRK05101
228400000426	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
228400000427	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
228400000428	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
228400000429	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
228400000430	active site
228400000431	catalytic residues [active]
228400000432	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
228400000433	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
228400000434	Transporter associated domain; Region: CorC_HlyC; smart01091
228400000435	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
228400000436	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
228400000437	putative active site [active]
228400000438	catalytic triad [active]
228400000439	putative dimer interface [polypeptide binding]; other site
228400000440	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
228400000441	active site
228400000442	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
228400000443	substrate binding site [chemical binding]; other site
228400000444	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
228400000445	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
228400000446	active site
228400000447	HIGH motif; other site
228400000448	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
228400000449	KMSKS motif; other site
228400000450	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
228400000451	tRNA binding surface [nucleotide binding]; other site
228400000452	anticodon binding site; other site
228400000453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
228400000454	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
228400000455	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
228400000456	substrate binding pocket [chemical binding]; other site
228400000457	chain length determination region; other site
228400000458	substrate-Mg2+ binding site; other site
228400000459	catalytic residues [active]
228400000460	aspartate-rich region 1; other site
228400000461	active site lid residues [active]
228400000462	aspartate-rich region 2; other site
228400000463	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
228400000464	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
228400000465	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
228400000466	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
228400000467	EamA-like transporter family; Region: EamA; pfam00892
228400000468	GTPase CgtA; Reviewed; Region: obgE; PRK12298
228400000469	GTP1/OBG; Region: GTP1_OBG; pfam01018
228400000470	Obg GTPase; Region: Obg; cd01898
228400000471	G1 box; other site
228400000472	GTP/Mg2+ binding site [chemical binding]; other site
228400000473	Switch I region; other site
228400000474	G2 box; other site
228400000475	G3 box; other site
228400000476	Switch II region; other site
228400000477	G4 box; other site
228400000478	G5 box; other site
228400000479	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
228400000480	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
228400000481	amidase catalytic site [active]
228400000482	Zn binding residues [ion binding]; other site
228400000483	substrate binding site [chemical binding]; other site
228400000484	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
228400000485	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
228400000486	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400000487	Walker A/P-loop; other site
228400000488	ATP binding site [chemical binding]; other site
228400000489	Q-loop/lid; other site
228400000490	ABC transporter signature motif; other site
228400000491	Walker B; other site
228400000492	D-loop; other site
228400000493	H-loop/switch region; other site
228400000494	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
228400000495	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
228400000496	substrate binding pocket [chemical binding]; other site
228400000497	membrane-bound complex binding site; other site
228400000498	hinge residues; other site
228400000499	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
228400000500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400000501	dimer interface [polypeptide binding]; other site
228400000502	conserved gate region; other site
228400000503	putative PBP binding loops; other site
228400000504	ABC-ATPase subunit interface; other site
228400000505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400000506	dimer interface [polypeptide binding]; other site
228400000507	conserved gate region; other site
228400000508	putative PBP binding loops; other site
228400000509	ABC-ATPase subunit interface; other site
228400000510	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
228400000511	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
228400000512	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
228400000513	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
228400000514	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
228400000515	active site
228400000516	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
228400000517	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
228400000518	colicin uptake protein TolR; Provisional; Region: PRK11024
228400000519	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
228400000520	TolA C-terminal; Region: TolA; pfam06519
228400000521	translocation protein TolB; Provisional; Region: tolB; PRK01742
228400000522	TolB amino-terminal domain; Region: TolB_N; pfam04052
228400000523	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
228400000524	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
228400000525	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
228400000526	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
228400000527	ligand binding site [chemical binding]; other site
228400000528	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
228400000529	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
228400000530	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
228400000531	PilX N-terminal; Region: PilX_N; pfam14341
228400000532	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
228400000533	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
228400000534	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
228400000535	RuvA N terminal domain; Region: RuvA_N; pfam01330
228400000536	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
228400000537	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
228400000538	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400000539	Walker A motif; other site
228400000540	ATP binding site [chemical binding]; other site
228400000541	Walker B motif; other site
228400000542	arginine finger; other site
228400000543	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
228400000544	Predicted flavoproteins [General function prediction only]; Region: COG2081
228400000545	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
228400000546	Methyltransferase domain; Region: Methyltransf_23; pfam13489
228400000547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400000548	S-adenosylmethionine binding site [chemical binding]; other site
228400000549	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
228400000550	Na binding site [ion binding]; other site
228400000551	ribonuclease G; Provisional; Region: PRK11712
228400000552	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
228400000553	homodimer interface [polypeptide binding]; other site
228400000554	oligonucleotide binding site [chemical binding]; other site
228400000555	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
228400000556	active site
228400000557	protease TldD; Provisional; Region: tldD; PRK10735
228400000558	Methyltransferase domain; Region: Methyltransf_31; pfam13847
228400000559	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400000560	S-adenosylmethionine binding site [chemical binding]; other site
228400000561	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
228400000562	Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797
228400000563	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
228400000564	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
228400000565	active site
228400000566	dimerization interface [polypeptide binding]; other site
228400000567	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
228400000568	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
228400000569	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
228400000570	Rrf2 family protein; Region: rrf2_super; TIGR00738
228400000571	cysteine desulfurase; Provisional; Region: PRK14012
228400000572	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
228400000573	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
228400000574	catalytic residue [active]
228400000575	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
228400000576	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
228400000577	trimerization site [polypeptide binding]; other site
228400000578	active site
228400000579	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
228400000580	co-chaperone HscB; Provisional; Region: hscB; PRK01773
228400000581	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
228400000582	HSP70 interaction site [polypeptide binding]; other site
228400000583	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
228400000584	chaperone protein HscA; Provisional; Region: hscA; PRK05183
228400000585	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
228400000586	nucleotide binding site [chemical binding]; other site
228400000587	putative NEF/HSP70 interaction site [polypeptide binding]; other site
228400000588	SBD interface [polypeptide binding]; other site
228400000589	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
228400000590	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
228400000591	catalytic loop [active]
228400000592	iron binding site [ion binding]; other site
228400000593	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
228400000594	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
228400000595	ATP-grasp domain; Region: ATP-grasp_4; cl17255
228400000596	ATP-grasp domain; Region: ATP-grasp_4; cl17255
228400000597	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
228400000598	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
228400000599	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
228400000600	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
228400000601	Nucleoside recognition; Region: Gate; pfam07670
228400000602	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
228400000603	Predicted membrane protein [Function unknown]; Region: COG2364
228400000604	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
228400000605	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
228400000606	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
228400000607	putative metal binding site; other site
228400000608	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
228400000609	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
228400000610	Substrate binding site; other site
228400000611	metal-binding site
228400000612	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
228400000613	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
228400000614	RimM N-terminal domain; Region: RimM; pfam01782
228400000615	PRC-barrel domain; Region: PRC; pfam05239
228400000616	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
228400000617	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
228400000618	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
228400000619	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
228400000620	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
228400000621	DNA binding site [nucleotide binding]
228400000622	domain linker motif; other site
228400000623	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
228400000624	putative ligand binding site [chemical binding]; other site
228400000625	putative dimerization interface [polypeptide binding]; other site
228400000626	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
228400000627	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
228400000628	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
228400000629	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
228400000630	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
228400000631	domain interface [polypeptide binding]; other site
228400000632	putative active site [active]
228400000633	catalytic site [active]
228400000634	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
228400000635	domain interface [polypeptide binding]; other site
228400000636	putative active site [active]
228400000637	catalytic site [active]
228400000638	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
228400000639	active site
228400000640	catalytic site [active]
228400000641	substrate binding site [chemical binding]; other site
228400000642	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
228400000643	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
228400000644	ligand binding site [chemical binding]; other site
228400000645	flexible hinge region; other site
228400000646	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc; cd04587
228400000647	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
228400000648	metal binding triad; other site
228400000649	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
228400000650	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
228400000651	substrate binding site [chemical binding]; other site
228400000652	ATP binding site [chemical binding]; other site
228400000653	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
228400000654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
228400000655	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
228400000656	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
228400000657	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
228400000658	putative active site [active]
228400000659	Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445
228400000660	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
228400000661	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400000662	S-adenosylmethionine binding site [chemical binding]; other site
228400000663	hypothetical protein; Provisional; Region: PRK11027
228400000664	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
228400000665	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
228400000666	catalytic residues [active]
228400000667	hinge region; other site
228400000668	alpha helical domain; other site
228400000669	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
228400000670	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
228400000671	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
228400000672	GTP binding site; other site
228400000673	Predicted membrane protein [Function unknown]; Region: COG1297
228400000674	putative oligopeptide transporter, OPT family; Region: TIGR00733
228400000675	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
228400000676	Sel1-like repeats; Region: SEL1; smart00671
228400000677	Sel1-like repeats; Region: SEL1; smart00671
228400000678	Sel1-like repeats; Region: SEL1; smart00671
228400000679	Sel1-like repeats; Region: SEL1; smart00671
228400000680	Sel1-like repeats; Region: SEL1; smart00671
228400000681	Lipoate synthase [Coenzyme metabolism]; Region: LipA; COG0320
228400000682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400000683	FeS/SAM binding site; other site
228400000684	lipoate-protein ligase B; Provisional; Region: PRK14342
228400000685	hypothetical protein; Provisional; Region: PRK04998
228400000686	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
228400000687	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
228400000688	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
228400000689	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
228400000690	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
228400000691	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
228400000692	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
228400000693	Oligomerisation domain; Region: Oligomerisation; cl00519
228400000694	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
228400000695	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
228400000696	ABC-ATPase subunit  interface; other site
228400000697	dimer interface [polypeptide binding]; other site
228400000698	putative PBP binding regions; other site
228400000699	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
228400000700	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
228400000701	ABC-ATPase subunit  interface; other site
228400000702	dimer interface [polypeptide binding]; other site
228400000703	putative PBP binding regions; other site
228400000704	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
228400000705	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
228400000706	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
228400000707	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
228400000708	metal binding site [ion binding]; metal-binding site
228400000709	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
228400000710	DsrC like protein; Region: DsrC; pfam04358
228400000711	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
228400000712	YccA-like proteins; Region: YccA_like; cd10433
228400000713	Mg chelatase-related protein; Region: TIGR00368
228400000714	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
228400000715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400000716	Walker A motif; other site
228400000717	ATP binding site [chemical binding]; other site
228400000718	Walker B motif; other site
228400000719	arginine finger; other site
228400000720	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
228400000721	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
228400000722	G1 box; other site
228400000723	GTP/Mg2+ binding site [chemical binding]; other site
228400000724	Switch I region; other site
228400000725	G2 box; other site
228400000726	G3 box; other site
228400000727	Switch II region; other site
228400000728	G4 box; other site
228400000729	G5 box; other site
228400000730	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
228400000731	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
228400000732	Substrate binding site; other site
228400000733	Mg++ binding site; other site
228400000734	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
228400000735	active site
228400000736	substrate binding site [chemical binding]; other site
228400000737	CoA binding site [chemical binding]; other site
228400000738	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
228400000739	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
228400000740	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
228400000741	putative active site [active]
228400000742	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
228400000743	putative transporter; Provisional; Region: PRK10484
228400000744	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
228400000745	Na binding site [ion binding]; other site
228400000746	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
228400000747	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
228400000748	Surface antigen; Region: Bac_surface_Ag; pfam01103
228400000749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
228400000750	Family of unknown function (DUF490); Region: DUF490; pfam04357
228400000751	Family of unknown function (DUF490); Region: DUF490; pfam04357
228400000752	exopolyphosphatase; Provisional; Region: PRK10854
228400000753	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
228400000754	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
228400000755	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
228400000756	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
228400000757	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
228400000758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400000759	Walker A motif; other site
228400000760	ATP binding site [chemical binding]; other site
228400000761	Walker B motif; other site
228400000762	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
228400000763	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
228400000764	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
228400000765	oligomer interface [polypeptide binding]; other site
228400000766	active site residues [active]
228400000767	trigger factor; Provisional; Region: tig; PRK01490
228400000768	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
228400000769	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
228400000770	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
228400000771	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
228400000772	Walker A motif; other site
228400000773	ATP binding site [chemical binding]; other site
228400000774	Walker B motif; other site
228400000775	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
228400000776	Domain of unknown function DUF21; Region: DUF21; pfam01595
228400000777	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
228400000778	Transporter associated domain; Region: CorC_HlyC; smart01091
228400000779	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
228400000780	signal recognition particle protein; Provisional; Region: PRK10867
228400000781	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
228400000782	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
228400000783	P loop; other site
228400000784	GTP binding site [chemical binding]; other site
228400000785	Signal peptide binding domain; Region: SRP_SPB; pfam02978
228400000786	putative transporter; Provisional; Region: PRK11660
228400000787	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
228400000788	Sulfate transporter family; Region: Sulfate_transp; pfam00916
228400000789	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
228400000790	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
228400000791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
228400000792	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
228400000793	Probable transposase; Region: OrfB_IS605; pfam01385
228400000794	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
228400000795	Transposase IS200 like; Region: Y1_Tnp; pfam01797
228400000796	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
228400000797	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
228400000798	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
228400000799	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
228400000800	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
228400000801	terminase ATPase subunit; Provisional; Region: P; PHA02535
228400000802	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
228400000803	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
228400000804	Phage-related protein [Function unknown]; Region: COG4695; cl01923
228400000805	Phage portal protein; Region: Phage_portal; pfam04860
228400000806	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
228400000807	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
228400000808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400000809	S-adenosylmethionine binding site [chemical binding]; other site
228400000810	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
228400000811	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
228400000812	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
228400000813	DNA methylase; Region: N6_N4_Mtase; pfam01555
228400000814	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
228400000815	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
228400000816	Domain of unknown function (DUF955); Region: DUF955; cl01076
228400000817	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400000818	non-specific DNA binding site [nucleotide binding]; other site
228400000819	salt bridge; other site
228400000820	sequence-specific DNA binding site [nucleotide binding]; other site
228400000821	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
228400000822	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
228400000823	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
228400000824	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
228400000825	ATP binding site [chemical binding]; other site
228400000826	active site
228400000827	substrate binding site [chemical binding]; other site
228400000828	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
228400000829	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
228400000830	putative NAD(P) binding site [chemical binding]; other site
228400000831	argininosuccinate synthase; Validated; Region: PRK05370
228400000832	argininosuccinate synthase; Provisional; Region: PRK13820
228400000833	Protein of unknown function (DUF535); Region: DUF535; pfam04393
228400000834	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
228400000835	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
228400000836	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
228400000837	active site
228400000838	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
228400000839	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
228400000840	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
228400000841	RNA/DNA hybrid binding site [nucleotide binding]; other site
228400000842	active site
228400000843	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
228400000844	MPT binding site; other site
228400000845	trimer interface [polypeptide binding]; other site
228400000846	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
228400000847	Nitrogen regulatory protein P-II; Region: P-II; smart00938
228400000848	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
228400000849	Domain of unknown function DUF20; Region: UPF0118; pfam01594
228400000850	HemK family putative methylases; Region: hemK_fam; TIGR00536
228400000851	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400000852	S-adenosylmethionine binding site [chemical binding]; other site
228400000853	hypothetical protein; Provisional; Region: PRK04946
228400000854	Smr domain; Region: Smr; pfam01713
228400000855	TIGR01666 family membrane protein; Region: YCCS
228400000856	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
228400000857	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
228400000858	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
228400000859	active site
228400000860	dimer interfaces [polypeptide binding]; other site
228400000861	catalytic residues [active]
228400000862	hypothetical protein; Provisional; Region: PRK01904
228400000863	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
228400000864	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
228400000865	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
228400000866	haemagglutination activity domain; Region: Haemagg_act; pfam05860
228400000867	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
228400000868	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
228400000869	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
228400000870	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
228400000871	cystathionine gamma-synthase; Reviewed; Region: PRK08247
228400000872	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
228400000873	homodimer interface [polypeptide binding]; other site
228400000874	substrate-cofactor binding pocket; other site
228400000875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400000876	catalytic residue [active]
228400000877	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
228400000878	catalytic residues [active]
228400000879	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
228400000880	DNA replication initiation factor; Validated; Region: PRK06893
228400000881	uracil-xanthine permease; Region: ncs2; TIGR00801
228400000882	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
228400000883	active site
228400000884	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
228400000885	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
228400000886	putative active site [active]
228400000887	putative dimer interface [polypeptide binding]; other site
228400000888	glutamate dehydrogenase; Provisional; Region: PRK09414
228400000889	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
228400000890	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
228400000891	NAD(P) binding site [chemical binding]; other site
228400000892	beta-D-glucuronidase; Provisional; Region: PRK10150
228400000893	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
228400000894	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
228400000895	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
228400000896	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
228400000897	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
228400000898	substrate binding site [chemical binding]; other site
228400000899	ATP binding site [chemical binding]; other site
228400000900	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
228400000901	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
228400000902	GDP-binding site [chemical binding]; other site
228400000903	ACT binding site; other site
228400000904	IMP binding site; other site
228400000905	peptidase PmbA; Provisional; Region: PRK11040
228400000906	hypothetical protein; Provisional; Region: PRK05255
228400000907	GTP-binding protein Der; Reviewed; Region: PRK00093
228400000908	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
228400000909	G1 box; other site
228400000910	GTP/Mg2+ binding site [chemical binding]; other site
228400000911	Switch I region; other site
228400000912	G2 box; other site
228400000913	Switch II region; other site
228400000914	G3 box; other site
228400000915	G4 box; other site
228400000916	G5 box; other site
228400000917	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
228400000918	G1 box; other site
228400000919	GTP/Mg2+ binding site [chemical binding]; other site
228400000920	Switch I region; other site
228400000921	G2 box; other site
228400000922	G3 box; other site
228400000923	Switch II region; other site
228400000924	G4 box; other site
228400000925	G5 box; other site
228400000926	DNA ligase; Provisional; Region: PRK09125
228400000927	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
228400000928	DNA binding site [nucleotide binding]
228400000929	active site
228400000930	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
228400000931	DNA binding site [nucleotide binding]
228400000932	putative protease; Provisional; Region: PRK15452
228400000933	Peptidase family U32; Region: Peptidase_U32; pfam01136
228400000934	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
228400000935	FIC domain binding interface [polypeptide binding]; other site
228400000936	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
228400000937	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
228400000938	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
228400000939	DctM-like transporters; Region: DctM; pfam06808
228400000940	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
228400000941	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
228400000942	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
228400000943	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
228400000944	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
228400000945	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
228400000946	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
228400000947	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
228400000948	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
228400000949	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
228400000950	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
228400000951	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
228400000952	Protein export membrane protein; Region: SecD_SecF; pfam02355
228400000953	DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056
228400000954	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
228400000955	active site
228400000956	putative interdomain interaction site [polypeptide binding]; other site
228400000957	putative metal-binding site [ion binding]; other site
228400000958	putative nucleotide binding site [chemical binding]; other site
228400000959	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
228400000960	domain I; other site
228400000961	DNA binding groove [nucleotide binding]
228400000962	phosphate binding site [ion binding]; other site
228400000963	domain II; other site
228400000964	domain III; other site
228400000965	nucleotide binding site [chemical binding]; other site
228400000966	catalytic site [active]
228400000967	domain IV; other site
228400000968	hypothetical protein; Validated; Region: PRK00153
228400000969	recombination protein RecR; Reviewed; Region: recR; PRK00076
228400000970	RecR protein; Region: RecR; pfam02132
228400000971	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
228400000972	putative active site [active]
228400000973	putative metal-binding site [ion binding]; other site
228400000974	tetramer interface [polypeptide binding]; other site
228400000975	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
228400000976	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
228400000977	active site
228400000978	HIGH motif; other site
228400000979	dimer interface [polypeptide binding]; other site
228400000980	KMSKS motif; other site
228400000981	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
228400000982	RNA binding surface [nucleotide binding]; other site
228400000983	prolyl-tRNA synthetase; Provisional; Region: PRK09194
228400000984	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
228400000985	dimer interface [polypeptide binding]; other site
228400000986	motif 1; other site
228400000987	active site
228400000988	motif 2; other site
228400000989	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
228400000990	putative deacylase active site [active]
228400000991	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
228400000992	active site
228400000993	motif 3; other site
228400000994	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
228400000995	anticodon binding site; other site
228400000996	recombination regulator RecX; Reviewed; Region: recX; PRK00117
228400000997	recombinase A; Provisional; Region: recA; PRK09354
228400000998	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
228400000999	hexamer interface [polypeptide binding]; other site
228400001000	Walker A motif; other site
228400001001	ATP binding site [chemical binding]; other site
228400001002	Walker B motif; other site
228400001003	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
228400001004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400001005	Walker A/P-loop; other site
228400001006	ATP binding site [chemical binding]; other site
228400001007	Q-loop/lid; other site
228400001008	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
228400001009	ABC transporter; Region: ABC_tran_2; pfam12848
228400001010	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
228400001011	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
228400001012	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
228400001013	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
228400001014	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
228400001015	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
228400001016	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
228400001017	active site
228400001018	Int/Topo IB signature motif; other site
228400001019	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
228400001020	homooctamer interface [polypeptide binding]; other site
228400001021	active site
228400001022	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
228400001023	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
228400001024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400001025	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
228400001026	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
228400001027	ATP binding site [chemical binding]; other site
228400001028	Mg++ binding site [ion binding]; other site
228400001029	motif III; other site
228400001030	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400001031	nucleotide binding region [chemical binding]; other site
228400001032	ATP-binding site [chemical binding]; other site
228400001033	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
228400001034	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
228400001035	hypothetical protein; Provisional; Region: PRK11820
228400001036	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
228400001037	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
228400001038	ribonuclease PH; Reviewed; Region: rph; PRK00173
228400001039	Ribonuclease PH; Region: RNase_PH_bact; cd11362
228400001040	hexamer interface [polypeptide binding]; other site
228400001041	active site
228400001042	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
228400001043	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
228400001044	putative metal binding site [ion binding]; other site
228400001045	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
228400001046	HSP70 interaction site [polypeptide binding]; other site
228400001047	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
228400001048	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
228400001049	FMN binding site [chemical binding]; other site
228400001050	active site
228400001051	catalytic residues [active]
228400001052	substrate binding site [chemical binding]; other site
228400001053	elongation factor P; Validated; Region: PRK00529
228400001054	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
228400001055	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
228400001056	RNA binding site [nucleotide binding]; other site
228400001057	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
228400001058	RNA binding site [nucleotide binding]; other site
228400001059	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
228400001060	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400001061	FeS/SAM binding site; other site
228400001062	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
228400001063	Putative exonuclease, RdgC; Region: RdgC; pfam04381
228400001064	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
228400001065	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
228400001066	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
228400001067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400001068	putative substrate translocation pore; other site
228400001069	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
228400001070	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
228400001071	active site
228400001072	Int/Topo IB signature motif; other site
228400001073	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400001074	trimer interface [polypeptide binding]; other site
228400001075	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400001076	trimer interface [polypeptide binding]; other site
228400001077	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400001078	trimer interface [polypeptide binding]; other site
228400001079	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400001080	trimer interface [polypeptide binding]; other site
228400001081	YadA-like C-terminal region; Region: YadA; pfam03895
228400001082	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
228400001083	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
228400001084	CAAX protease self-immunity; Region: Abi; pfam02517
228400001085	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
228400001086	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
228400001087	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
228400001088	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
228400001089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400001090	dimer interface [polypeptide binding]; other site
228400001091	conserved gate region; other site
228400001092	putative PBP binding loops; other site
228400001093	ABC-ATPase subunit interface; other site
228400001094	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
228400001095	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
228400001096	metal binding triad; other site
228400001097	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
228400001098	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
228400001099	metal binding triad; other site
228400001100	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
228400001101	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
228400001102	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400001103	trimer interface [polypeptide binding]; other site
228400001104	YadA-like C-terminal region; Region: YadA; pfam03895
228400001105	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
228400001106	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
228400001107	generic binding surface II; other site
228400001108	generic binding surface I; other site
228400001109	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
228400001110	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
228400001111	catalytic residue [active]
228400001112	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
228400001113	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
228400001114	nucleotide binding site [chemical binding]; other site
228400001115	substrate binding site [chemical binding]; other site
228400001116	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
228400001117	dimer interface [polypeptide binding]; other site
228400001118	putative threonine allosteric regulatory site; other site
228400001119	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
228400001120	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
228400001121	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
228400001122	homoserine kinase; Provisional; Region: PRK01212
228400001123	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
228400001124	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
228400001125	threonine synthase; Validated; Region: PRK09225
228400001126	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
228400001127	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
228400001128	catalytic residue [active]
228400001129	ferric uptake regulator; Provisional; Region: fur; PRK09462
228400001130	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
228400001131	metal binding site 2 [ion binding]; metal-binding site
228400001132	putative DNA binding helix; other site
228400001133	metal binding site 1 [ion binding]; metal-binding site
228400001134	dimer interface [polypeptide binding]; other site
228400001135	structural Zn2+ binding site [ion binding]; other site
228400001136	flavodoxin FldA; Validated; Region: PRK09267
228400001137	acyl-CoA esterase; Provisional; Region: PRK10673
228400001138	PGAP1-like protein; Region: PGAP1; pfam07819
228400001139	replication initiation regulator SeqA; Provisional; Region: PRK11187
228400001140	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
228400001141	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
228400001142	acyl-activating enzyme (AAE) consensus motif; other site
228400001143	putative AMP binding site [chemical binding]; other site
228400001144	putative active site [active]
228400001145	putative CoA binding site [chemical binding]; other site
228400001146	hypothetical protein; Provisional; Region: PRK11281
228400001147	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
228400001148	Mechanosensitive ion channel; Region: MS_channel; pfam00924
228400001149	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
228400001150	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
228400001151	Tetramer interface [polypeptide binding]; other site
228400001152	active site
228400001153	FMN-binding site [chemical binding]; other site
228400001154	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
228400001155	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
228400001156	hypothetical protein; Provisional; Region: PRK10621
228400001157	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
228400001158	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
228400001159	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
228400001160	putative acyl-acceptor binding pocket; other site
228400001161	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
228400001162	active site
228400001163	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
228400001164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400001165	Walker A motif; other site
228400001166	ATP binding site [chemical binding]; other site
228400001167	Walker B motif; other site
228400001168	DNA polymerase III subunit delta'; Validated; Region: PRK08485
228400001169	arginine finger; other site
228400001170	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
228400001171	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
228400001172	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
228400001173	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400001174	FeS/SAM binding site; other site
228400001175	TPR repeat; Region: TPR_11; pfam13414
228400001176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
228400001177	binding surface
228400001178	TPR motif; other site
228400001179	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
228400001180	ATP cone domain; Region: ATP-cone; pfam03477
228400001181	Class I ribonucleotide reductase; Region: RNR_I; cd01679
228400001182	active site
228400001183	dimer interface [polypeptide binding]; other site
228400001184	catalytic residues [active]
228400001185	effector binding site; other site
228400001186	R2 peptide binding site; other site
228400001187	chaperone protein DnaJ; Provisional; Region: PRK10767
228400001188	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
228400001189	HSP70 interaction site [polypeptide binding]; other site
228400001190	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
228400001191	substrate binding site [polypeptide binding]; other site
228400001192	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
228400001193	Zn binding sites [ion binding]; other site
228400001194	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
228400001195	dimer interface [polypeptide binding]; other site
228400001196	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
228400001197	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
228400001198	nucleotide binding site [chemical binding]; other site
228400001199	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
228400001200	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
228400001201	active site
228400001202	NTP binding site [chemical binding]; other site
228400001203	metal binding triad [ion binding]; metal-binding site
228400001204	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
228400001205	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
228400001206	Zn2+ binding site [ion binding]; other site
228400001207	Mg2+ binding site [ion binding]; other site
228400001208	Bacterial SH3 domain homologues; Region: SH3b; smart00287
228400001209	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
228400001210	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
228400001211	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
228400001212	TIGR00153 family protein; Region: TIGR00153
228400001213	Uncharacterized conserved protein [Function unknown]; Region: COG3025
228400001214	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
228400001215	putative active site [active]
228400001216	putative metal binding residues [ion binding]; other site
228400001217	signature motif; other site
228400001218	putative triphosphate binding site [ion binding]; other site
228400001219	DNA repair protein RadA; Provisional; Region: PRK11823
228400001220	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
228400001221	Walker A motif/ATP binding site; other site
228400001222	ATP binding site [chemical binding]; other site
228400001223	Walker B motif; other site
228400001224	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
228400001225	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
228400001226	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
228400001227	putative DNA binding site [nucleotide binding]; other site
228400001228	putative Zn2+ binding site [ion binding]; other site
228400001229	AsnC family; Region: AsnC_trans_reg; pfam01037
228400001230	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
228400001231	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
228400001232	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
228400001233	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
228400001234	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400001235	trimer interface [polypeptide binding]; other site
228400001236	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400001237	trimer interface [polypeptide binding]; other site
228400001238	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400001239	trimer interface [polypeptide binding]; other site
228400001240	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400001241	trimer interface [polypeptide binding]; other site
228400001242	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400001243	trimer interface [polypeptide binding]; other site
228400001244	YadA-like C-terminal region; Region: YadA; pfam03895
228400001245	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
228400001246	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
228400001247	RNase E inhibitor protein; Provisional; Region: PRK11191
228400001248	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
228400001249	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
228400001250	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
228400001251	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
228400001252	active site
228400001253	substrate-binding site [chemical binding]; other site
228400001254	metal-binding site [ion binding]
228400001255	ATP binding site [chemical binding]; other site
228400001256	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
228400001257	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
228400001258	dimer interface [polypeptide binding]; other site
228400001259	active site
228400001260	glycine-pyridoxal phosphate binding site [chemical binding]; other site
228400001261	folate binding site [chemical binding]; other site
228400001262	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
228400001263	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
228400001264	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
228400001265	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
228400001266	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
228400001267	Sulfatase; Region: Sulfatase; pfam00884
228400001268	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
228400001269	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
228400001270	purine monophosphate binding site [chemical binding]; other site
228400001271	dimer interface [polypeptide binding]; other site
228400001272	putative catalytic residues [active]
228400001273	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
228400001274	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
228400001275	hypothetical protein; Provisional; Region: PRK04860
228400001276	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
228400001277	S-adenosylmethionine synthetase; Validated; Region: PRK05250
228400001278	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
228400001279	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
228400001280	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
228400001281	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
228400001282	putative active site [active]
228400001283	Ap4A binding site [chemical binding]; other site
228400001284	nudix motif; other site
228400001285	putative metal binding site [ion binding]; other site
228400001286	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
228400001287	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
228400001288	thymidylate synthase; Reviewed; Region: thyA; PRK01827
228400001289	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
228400001290	dimerization interface [polypeptide binding]; other site
228400001291	active site
228400001292	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
228400001293	nucleoside/Zn binding site; other site
228400001294	dimer interface [polypeptide binding]; other site
228400001295	catalytic motif [active]
228400001296	excinuclease ABC subunit B; Provisional; Region: PRK05298
228400001297	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400001298	ATP binding site [chemical binding]; other site
228400001299	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400001300	nucleotide binding region [chemical binding]; other site
228400001301	ATP-binding site [chemical binding]; other site
228400001302	Ultra-violet resistance protein B; Region: UvrB; pfam12344
228400001303	UvrB/uvrC motif; Region: UVR; pfam02151
228400001304	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400001305	trimer interface [polypeptide binding]; other site
228400001306	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400001307	trimer interface [polypeptide binding]; other site
228400001308	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400001309	trimer interface [polypeptide binding]; other site
228400001310	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400001311	trimer interface [polypeptide binding]; other site
228400001312	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400001313	trimer interface [polypeptide binding]; other site
228400001314	PspA/IM30 family; Region: PspA_IM30; pfam04012
228400001315	YadA-like C-terminal region; Region: YadA; pfam03895
228400001316	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
228400001317	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
228400001318	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
228400001319	RmuC family; Region: RmuC; pfam02646
228400001320	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
228400001321	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
228400001322	NADP binding site [chemical binding]; other site
228400001323	homopentamer interface [polypeptide binding]; other site
228400001324	substrate binding site [chemical binding]; other site
228400001325	active site
228400001326	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
228400001327	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
228400001328	putative active site [active]
228400001329	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
228400001330	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
228400001331	putative active site [active]
228400001332	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
228400001333	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
228400001334	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
228400001335	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
228400001336	Walker A motif; other site
228400001337	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
228400001338	anti-sigma E factor; Provisional; Region: rseB; PRK09455
228400001339	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
228400001340	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
228400001341	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
228400001342	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
228400001343	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
228400001344	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
228400001345	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
228400001346	DNA binding residues [nucleotide binding]
228400001347	Uncharacterized conserved protein [Function unknown]; Region: COG2938
228400001348	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
228400001349	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
228400001350	active site
228400001351	intersubunit interface [polypeptide binding]; other site
228400001352	catalytic residue [active]
228400001353	Glucuronate isomerase; Region: UxaC; pfam02614
228400001354	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
228400001355	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
228400001356	MFS/sugar transport protein; Region: MFS_2; pfam13347
228400001357	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
228400001358	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
228400001359	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
228400001360	D-mannonate oxidoreductase; Provisional; Region: PRK08277
228400001361	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
228400001362	putative NAD(P) binding site [chemical binding]; other site
228400001363	active site
228400001364	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
228400001365	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
228400001366	DNA-binding site [nucleotide binding]; DNA binding site
228400001367	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
228400001368	mannonate dehydratase; Provisional; Region: PRK03906
228400001369	mannonate dehydratase; Region: uxuA; TIGR00695
228400001370	putative lysogenization regulator; Reviewed; Region: PRK00218
228400001371	adenylosuccinate lyase; Provisional; Region: PRK09285
228400001372	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
228400001373	tetramer interface [polypeptide binding]; other site
228400001374	active site
228400001375	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
228400001376	triosephosphate isomerase; Provisional; Region: PRK14567
228400001377	substrate binding site [chemical binding]; other site
228400001378	dimer interface [polypeptide binding]; other site
228400001379	catalytic triad [active]
228400001380	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
228400001381	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
228400001382	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
228400001383	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
228400001384	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
228400001385	active site
228400001386	(T/H)XGH motif; other site
228400001387	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
228400001388	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
228400001389	Walker A/P-loop; other site
228400001390	ATP binding site [chemical binding]; other site
228400001391	Q-loop/lid; other site
228400001392	ABC transporter signature motif; other site
228400001393	Walker B; other site
228400001394	D-loop; other site
228400001395	H-loop/switch region; other site
228400001396	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
228400001397	Major Facilitator Superfamily; Region: MFS_1; pfam07690
228400001398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400001399	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
228400001400	active site
228400001401	catalytic site [active]
228400001402	putative metal binding site [ion binding]; other site
228400001403	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
228400001404	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
228400001405	tetrameric interface [polypeptide binding]; other site
228400001406	NAD binding site [chemical binding]; other site
228400001407	catalytic residues [active]
228400001408	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
228400001409	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
228400001410	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
228400001411	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
228400001412	putative ligand binding site [chemical binding]; other site
228400001413	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
228400001414	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
228400001415	putative ligand binding site [chemical binding]; other site
228400001416	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
228400001417	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400001418	Walker A/P-loop; other site
228400001419	ATP binding site [chemical binding]; other site
228400001420	Q-loop/lid; other site
228400001421	ABC transporter signature motif; other site
228400001422	Walker B; other site
228400001423	D-loop; other site
228400001424	H-loop/switch region; other site
228400001425	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400001426	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400001427	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400001428	TM-ABC transporter signature motif; other site
228400001429	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
228400001430	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
228400001431	PYR/PP interface [polypeptide binding]; other site
228400001432	dimer interface [polypeptide binding]; other site
228400001433	TPP binding site [chemical binding]; other site
228400001434	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
228400001435	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
228400001436	TPP-binding site; other site
228400001437	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
228400001438	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
228400001439	Metal-binding active site; metal-binding site
228400001440	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
228400001441	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
228400001442	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
228400001443	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
228400001444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
228400001445	RNA methyltransferase, RsmE family; Region: TIGR00046
228400001446	putrescine transporter; Provisional; Region: potE; PRK10655
228400001447	ornithine decarboxylase; Provisional; Region: PRK13578
228400001448	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
228400001449	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
228400001450	homodimer interface [polypeptide binding]; other site
228400001451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400001452	catalytic residue [active]
228400001453	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
228400001454	Protein of unknown function (DUF2618); Region: DUF2618; pfam10940
228400001455	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
228400001456	CPxP  motif; other site
228400001457	hypothetical protein; Provisional; Region: PRK11568
228400001458	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
228400001459	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
228400001460	Cation transport protein; Region: TrkH; cl17365
228400001461	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
228400001462	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
228400001463	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
228400001464	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
228400001465	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
228400001466	AAA domain; Region: AAA_30; pfam13604
228400001467	Family description; Region: UvrD_C_2; pfam13538
228400001468	uridine phosphorylase; Provisional; Region: PRK11178
228400001469	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
228400001470	Winged helix-turn helix; Region: HTH_29; pfam13551
228400001471	methionine cluster; other site
228400001472	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
228400001473	active site
228400001474	phosphorylation site [posttranslational modification]
228400001475	metal binding site [ion binding]; metal-binding site
228400001476	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
228400001477	active site
228400001478	P-loop; other site
228400001479	phosphorylation site [posttranslational modification]
228400001480	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
228400001481	interface (dimer of trimers) [polypeptide binding]; other site
228400001482	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
228400001483	Substrate-binding/catalytic site; other site
228400001484	Zn-binding sites [ion binding]; other site
228400001485	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
228400001486	active site
228400001487	dimer interface [polypeptide binding]; other site
228400001488	catalytic nucleophile [active]
228400001489	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
228400001490	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
228400001491	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
228400001492	ATP-dependent helicase HepA; Validated; Region: PRK04914
228400001493	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400001494	ATP binding site [chemical binding]; other site
228400001495	putative Mg++ binding site [ion binding]; other site
228400001496	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400001497	nucleotide binding region [chemical binding]; other site
228400001498	ATP-binding site [chemical binding]; other site
228400001499	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
228400001500	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
228400001501	active site
228400001502	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
228400001503	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
228400001504	dimer interface [polypeptide binding]; other site
228400001505	substrate binding site [chemical binding]; other site
228400001506	metal binding sites [ion binding]; metal-binding site
228400001507	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
228400001508	aromatic amino acid transport protein; Region: araaP; TIGR00837
228400001509	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
228400001510	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
228400001511	active site
228400001512	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
228400001513	SurA N-terminal domain; Region: SurA_N; pfam09312
228400001514	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
228400001515	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
228400001516	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
228400001517	S-adenosylmethionine binding site [chemical binding]; other site
228400001518	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
228400001519	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
228400001520	active site
228400001521	metal binding site [ion binding]; metal-binding site
228400001522	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
228400001523	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
228400001524	HIGH motif; other site
228400001525	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
228400001526	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
228400001527	active site
228400001528	KMSKS motif; other site
228400001529	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
228400001530	tRNA binding surface [nucleotide binding]; other site
228400001531	Lipopolysaccharide-assembly; Region: LptE; cl01125
228400001532	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
228400001533	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
228400001534	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
228400001535	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
228400001536	Walker A/P-loop; other site
228400001537	ATP binding site [chemical binding]; other site
228400001538	Q-loop/lid; other site
228400001539	ABC transporter signature motif; other site
228400001540	Walker B; other site
228400001541	D-loop; other site
228400001542	H-loop/switch region; other site
228400001543	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
228400001544	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
228400001545	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
228400001546	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
228400001547	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
228400001548	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
228400001549	dimerization interface [polypeptide binding]; other site
228400001550	putative ATP binding site [chemical binding]; other site
228400001551	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
228400001552	putative DNA-binding cleft [nucleotide binding]; other site
228400001553	putative DNA clevage site; other site
228400001554	molecular lever; other site
228400001555	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
228400001556	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
228400001557	DNA binding site [nucleotide binding]
228400001558	active site
228400001559	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
228400001560	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
228400001561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
228400001562	Pirin-related protein [General function prediction only]; Region: COG1741
228400001563	Pirin; Region: Pirin; pfam02678
228400001564	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
228400001565	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
228400001566	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
228400001567	DNA binding residues [nucleotide binding]
228400001568	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
228400001569	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
228400001570	FAD binding domain; Region: FAD_binding_4; pfam01565
228400001571	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
228400001572	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
228400001573	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
228400001574	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
228400001575	dimerization interface [polypeptide binding]; other site
228400001576	Histidine kinase; Region: HisKA_3; pfam07730
228400001577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
228400001578	ATP binding site [chemical binding]; other site
228400001579	Mg2+ binding site [ion binding]; other site
228400001580	G-X-G motif; other site
228400001581	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
228400001582	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
228400001583	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400001584	ATP binding site [chemical binding]; other site
228400001585	putative Mg++ binding site [ion binding]; other site
228400001586	Virulence protein [General function prediction only]; Region: COG3943
228400001587	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
228400001588	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400001589	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400001590	Divergent AAA domain; Region: AAA_4; pfam04326
228400001591	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
228400001592	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
228400001593	NapD protein; Region: NapD; pfam03927
228400001594	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
228400001595	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
228400001596	[4Fe-4S] binding site [ion binding]; other site
228400001597	molybdopterin cofactor binding site; other site
228400001598	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
228400001599	molybdopterin cofactor binding site; other site
228400001600	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
228400001601	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
228400001602	4Fe-4S binding domain; Region: Fer4_5; pfam12801
228400001603	4Fe-4S binding domain; Region: Fer4; cl02805
228400001604	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
228400001605	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
228400001606	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
228400001607	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
228400001608	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
228400001609	dimerization interface [polypeptide binding]; other site
228400001610	ATP binding site [chemical binding]; other site
228400001611	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
228400001612	dimerization interface [polypeptide binding]; other site
228400001613	ATP binding site [chemical binding]; other site
228400001614	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
228400001615	putative active site [active]
228400001616	catalytic triad [active]
228400001617	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
228400001618	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
228400001619	Peptidase family M23; Region: Peptidase_M23; pfam01551
228400001620	Predicted membrane protein [Function unknown]; Region: COG1238
228400001621	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
228400001622	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
228400001623	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
228400001624	Permutation of conserved domain; other site
228400001625	active site
228400001626	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
228400001627	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
228400001628	homotrimer interaction site [polypeptide binding]; other site
228400001629	zinc binding site [ion binding]; other site
228400001630	CDP-binding sites; other site
228400001631	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
228400001632	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
228400001633	TrkA-N domain; Region: TrkA_N; pfam02254
228400001634	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
228400001635	substrate binding site; other site
228400001636	dimer interface; other site
228400001637	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
228400001638	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
228400001639	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
228400001640	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
228400001641	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
228400001642	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
228400001643	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
228400001644	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
228400001645	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
228400001646	RNA binding site [nucleotide binding]; other site
228400001647	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
228400001648	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
228400001649	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
228400001650	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
228400001651	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
228400001652	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
228400001653	active site
228400001654	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
228400001655	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400001656	active site
228400001657	motif I; other site
228400001658	motif II; other site
228400001659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400001660	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
228400001661	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
228400001662	dimerization interface [polypeptide binding]; other site
228400001663	thymidylate kinase; Validated; Region: tmk; PRK00698
228400001664	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
228400001665	TMP-binding site; other site
228400001666	ATP-binding site [chemical binding]; other site
228400001667	DNA polymerase III subunit delta'; Validated; Region: PRK06871
228400001668	DNA polymerase III subunit delta'; Validated; Region: PRK08485
228400001669	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
228400001670	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
228400001671	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
228400001672	active site
228400001673	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
228400001674	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
228400001675	Domain of unknown function DUF21; Region: DUF21; pfam01595
228400001676	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
228400001677	Transporter associated domain; Region: CorC_HlyC; smart01091
228400001678	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
228400001679	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
228400001680	Predicted membrane protein [Function unknown]; Region: COG1584
228400001681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400001682	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
228400001683	putative substrate translocation pore; other site
228400001684	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
228400001685	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
228400001686	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
228400001687	dimer interface [polypeptide binding]; other site
228400001688	putative anticodon binding site; other site
228400001689	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
228400001690	motif 1; other site
228400001691	active site
228400001692	motif 2; other site
228400001693	motif 3; other site
228400001694	peptide chain release factor 2; Provisional; Region: PRK08787
228400001695	This domain is found in peptide chain release factors; Region: PCRF; smart00937
228400001696	RF-1 domain; Region: RF-1; pfam00472
228400001697	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
228400001698	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
228400001699	dimerization domain [polypeptide binding]; other site
228400001700	dimer interface [polypeptide binding]; other site
228400001701	catalytic residues [active]
228400001702	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
228400001703	DHH family; Region: DHH; pfam01368
228400001704	DHHA1 domain; Region: DHHA1; pfam02272
228400001705	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
228400001706	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
228400001707	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
228400001708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
228400001709	HTH-like domain; Region: HTH_21; pfam13276
228400001710	Integrase core domain; Region: rve_2; pfam13333
228400001711	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
228400001712	putative transporter; Validated; Region: PRK03818
228400001713	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
228400001714	TrkA-C domain; Region: TrkA_C; pfam02080
228400001715	TrkA-C domain; Region: TrkA_C; pfam02080
228400001716	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
228400001717	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
228400001718	ATP cone domain; Region: ATP-cone; pfam03477
228400001719	Class III ribonucleotide reductase; Region: RNR_III; cd01675
228400001720	effector binding site; other site
228400001721	active site
228400001722	Zn binding site [ion binding]; other site
228400001723	glycine loop; other site
228400001724	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
228400001725	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400001726	FeS/SAM binding site; other site
228400001727	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
228400001728	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
228400001729	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
228400001730	putative active site [active]
228400001731	putative NTP binding site [chemical binding]; other site
228400001732	putative nucleic acid binding site [nucleotide binding]; other site
228400001733	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
228400001734	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
228400001735	active site
228400001736	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
228400001737	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
228400001738	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
228400001739	Phosphotransferase enzyme family; Region: APH; pfam01636
228400001740	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
228400001741	active site
228400001742	substrate binding site [chemical binding]; other site
228400001743	ATP binding site [chemical binding]; other site
228400001744	dimer interface [polypeptide binding]; other site
228400001745	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
228400001746	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
228400001747	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
228400001748	active site
228400001749	metal-binding site
228400001750	LicD family; Region: LicD; cl01378
228400001751	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
228400001752	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
228400001753	catalytic site [active]
228400001754	G-X2-G-X-G-K; other site
228400001755	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
228400001756	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
228400001757	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
228400001758	Zn2+ binding site [ion binding]; other site
228400001759	Mg2+ binding site [ion binding]; other site
228400001760	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
228400001761	synthetase active site [active]
228400001762	NTP binding site [chemical binding]; other site
228400001763	metal binding site [ion binding]; metal-binding site
228400001764	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
228400001765	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
228400001766	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
228400001767	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
228400001768	generic binding surface II; other site
228400001769	ssDNA binding site; other site
228400001770	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400001771	ATP binding site [chemical binding]; other site
228400001772	putative Mg++ binding site [ion binding]; other site
228400001773	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400001774	nucleotide binding region [chemical binding]; other site
228400001775	ATP-binding site [chemical binding]; other site
228400001776	glutamate racemase; Provisional; Region: PRK00865
228400001777	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
228400001778	EamA-like transporter family; Region: EamA; pfam00892
228400001779	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
228400001780	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
228400001781	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
228400001782	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
228400001783	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
228400001784	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
228400001785	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
228400001786	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
228400001787	RPB1 interaction site [polypeptide binding]; other site
228400001788	RPB11 interaction site [polypeptide binding]; other site
228400001789	RPB10 interaction site [polypeptide binding]; other site
228400001790	RPB3 interaction site [polypeptide binding]; other site
228400001791	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
228400001792	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
228400001793	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
228400001794	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
228400001795	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
228400001796	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
228400001797	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
228400001798	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
228400001799	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
228400001800	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
228400001801	DNA binding site [nucleotide binding]
228400001802	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
228400001803	DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337
228400001804	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
228400001805	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
228400001806	putative active site [active]
228400001807	D-allose transporter subunit; Provisional; Region: PRK09701
228400001808	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
228400001809	D-allose transporter ATP-binding protein; Provisional; Region: PRK09700
228400001810	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400001811	Walker A/P-loop; other site
228400001812	ATP binding site [chemical binding]; other site
228400001813	Q-loop/lid; other site
228400001814	ABC transporter signature motif; other site
228400001815	Walker B; other site
228400001816	D-loop; other site
228400001817	H-loop/switch region; other site
228400001818	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400001819	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400001820	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400001821	TM-ABC transporter signature motif; other site
228400001822	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
228400001823	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
228400001824	substrate binding site [chemical binding]; other site
228400001825	hexamer interface [polypeptide binding]; other site
228400001826	metal binding site [ion binding]; metal-binding site
228400001827	D-allose kinase; Provisional; Region: PRK09698
228400001828	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
228400001829	nucleotide binding site [chemical binding]; other site
228400001830	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
228400001831	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
228400001832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400001833	Walker A motif; other site
228400001834	ATP binding site [chemical binding]; other site
228400001835	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
228400001836	Walker B motif; other site
228400001837	arginine finger; other site
228400001838	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
228400001839	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
228400001840	HslU subunit interaction site [polypeptide binding]; other site
228400001841	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
228400001842	substrate binding site [chemical binding]; other site
228400001843	active site
228400001844	Protein of unknown function (DUF416); Region: DUF416; cl01166
228400001845	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
228400001846	IHF dimer interface [polypeptide binding]; other site
228400001847	IHF - DNA interface [nucleotide binding]; other site
228400001848	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
228400001849	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
228400001850	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
228400001851	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
228400001852	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
228400001853	glutaminase active site [active]
228400001854	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
228400001855	dimer interface [polypeptide binding]; other site
228400001856	active site
228400001857	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
228400001858	dimer interface [polypeptide binding]; other site
228400001859	active site
228400001860	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
228400001861	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
228400001862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400001863	dimer interface [polypeptide binding]; other site
228400001864	conserved gate region; other site
228400001865	ABC-ATPase subunit interface; other site
228400001866	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
228400001867	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
228400001868	Walker A/P-loop; other site
228400001869	ATP binding site [chemical binding]; other site
228400001870	Q-loop/lid; other site
228400001871	ABC transporter signature motif; other site
228400001872	Walker B; other site
228400001873	D-loop; other site
228400001874	H-loop/switch region; other site
228400001875	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
228400001876	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
228400001877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400001878	active site
228400001879	motif I; other site
228400001880	motif II; other site
228400001881	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400001882	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400001883	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
228400001884	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
228400001885	fructuronate transporter; Provisional; Region: PRK10034; cl15264
228400001886	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
228400001887	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
228400001888	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
228400001889	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
228400001890	L-fuculose phosphate aldolase; Provisional; Region: PRK08087
228400001891	intersubunit interface [polypeptide binding]; other site
228400001892	active site
228400001893	Zn2+ binding site [ion binding]; other site
228400001894	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
228400001895	L-fuculokinase; Provisional; Region: PRK10331
228400001896	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
228400001897	nucleotide binding site [chemical binding]; other site
228400001898	L-fucose isomerase; Provisional; Region: fucI; PRK10991
228400001899	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
228400001900	hexamer (dimer of trimers) interface [polypeptide binding]; other site
228400001901	trimer interface [polypeptide binding]; other site
228400001902	substrate binding site [chemical binding]; other site
228400001903	Mn binding site [ion binding]; other site
228400001904	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
228400001905	L-fucose transporter; Provisional; Region: PRK10133; cl17665
228400001906	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
228400001907	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
228400001908	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
228400001909	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
228400001910	catalytic core [active]
228400001911	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
228400001912	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
228400001913	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
228400001914	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400001915	FeS/SAM binding site; other site
228400001916	AmiB activator; Provisional; Region: PRK11637
228400001917	Peptidase family M23; Region: Peptidase_M23; pfam01551
228400001918	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
228400001919	NodB motif; other site
228400001920	putative active site [active]
228400001921	putative catalytic site [active]
228400001922	Zn binding site [ion binding]; other site
228400001923	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
228400001924	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
228400001925	putative DNA binding site [nucleotide binding]; other site
228400001926	putative Zn2+ binding site [ion binding]; other site
228400001927	AsnC family; Region: AsnC_trans_reg; pfam01037
228400001928	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
228400001929	dimer interface [polypeptide binding]; other site
228400001930	active site
228400001931	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
228400001932	MgtC family; Region: MgtC; pfam02308
228400001933	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
228400001934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
228400001935	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
228400001936	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
228400001937	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
228400001938	cofactor binding site; other site
228400001939	DNA binding site [nucleotide binding]
228400001940	substrate interaction site [chemical binding]; other site
228400001941	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
228400001942	Putative catalytic domain of type II restriction enzyme NgoFVII and similar proteins; Region: PLDc_RE_NgoFVII; cd09177
228400001943	PLD-like domain; Region: PLDc_2; pfam13091
228400001944	putative homodimer interface [polypeptide binding]; other site
228400001945	putative active site [active]
228400001946	catalytic site [active]
228400001947	DEAD-like helicases superfamily; Region: DEXDc; smart00487
228400001948	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400001949	ATP binding site [chemical binding]; other site
228400001950	putative Mg++ binding site [ion binding]; other site
228400001951	Z1 domain; Region: Z1; pfam10593
228400001952	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
228400001953	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400001954	non-specific DNA binding site [nucleotide binding]; other site
228400001955	salt bridge; other site
228400001956	sequence-specific DNA binding site [nucleotide binding]; other site
228400001957	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
228400001958	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
228400001959	dimer interface [polypeptide binding]; other site
228400001960	ssDNA binding site [nucleotide binding]; other site
228400001961	tetramer (dimer of dimers) interface [polypeptide binding]; other site
228400001962	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
228400001963	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
228400001964	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
228400001965	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
228400001966	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
228400001967	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
228400001968	metal binding site [ion binding]; metal-binding site
228400001969	dimer interface [polypeptide binding]; other site
228400001970	Protein of unknown function (DUF511); Region: DUF511; pfam04373
228400001971	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
228400001972	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
228400001973	Methyltransferase domain; Region: Methyltransf_26; pfam13659
228400001974	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
228400001975	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400001976	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
228400001977	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400001978	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
228400001979	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
228400001980	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
228400001981	PhoH-like protein; Region: PhoH; pfam02562
228400001982	metal-binding heat shock protein; Provisional; Region: PRK00016
228400001983	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
228400001984	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
228400001985	Helicase; Region: Helicase_RecD; pfam05127
228400001986	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
228400001987	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
228400001988	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
228400001989	Carbon starvation protein CstA; Region: CstA; pfam02554
228400001990	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
228400001991	cell division protein MraZ; Reviewed; Region: PRK00326
228400001992	MraZ protein; Region: MraZ; pfam02381
228400001993	MraZ protein; Region: MraZ; pfam02381
228400001994	MraW methylase family; Region: Methyltransf_5; pfam01795
228400001995	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
228400001996	Cell division protein FtsL; Region: FtsL; pfam04999
228400001997	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
228400001998	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
228400001999	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
228400002000	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
228400002001	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
228400002002	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
228400002003	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
228400002004	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
228400002005	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
228400002006	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
228400002007	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
228400002008	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
228400002009	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
228400002010	Mg++ binding site [ion binding]; other site
228400002011	putative catalytic motif [active]
228400002012	putative substrate binding site [chemical binding]; other site
228400002013	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
228400002014	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
228400002015	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
228400002016	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
228400002017	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
228400002018	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
228400002019	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
228400002020	active site
228400002021	homodimer interface [polypeptide binding]; other site
228400002022	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
228400002023	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
228400002024	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
228400002025	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
228400002026	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
228400002027	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
228400002028	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
228400002029	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
228400002030	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
228400002031	Cell division protein FtsQ; Region: FtsQ; pfam03799
228400002032	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
228400002033	Cell division protein FtsA; Region: FtsA; smart00842
228400002034	Cell division protein FtsA; Region: FtsA; pfam14450
228400002035	cell division protein FtsZ; Validated; Region: PRK09330
228400002036	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
228400002037	nucleotide binding site [chemical binding]; other site
228400002038	SulA interaction site; other site
228400002039	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
228400002040	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
228400002041	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
228400002042	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
228400002043	Prephenate dehydratase; Region: PDT; pfam00800
228400002044	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
228400002045	putative L-Phe binding site [chemical binding]; other site
228400002046	Outer membrane lipoprotein; Region: YfiO; pfam13525
228400002047	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
228400002048	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
228400002049	RNA binding surface [nucleotide binding]; other site
228400002050	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
228400002051	active site
228400002052	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
228400002053	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
228400002054	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
228400002055	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
228400002056	dimer interface [polypeptide binding]; other site
228400002057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400002058	catalytic residue [active]
228400002059	putative sulfate transport protein CysZ; Validated; Region: PRK04949
228400002060	cell division protein ZipA; Provisional; Region: PRK01741
228400002061	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
228400002062	FtsZ protein binding site [polypeptide binding]; other site
228400002063	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
228400002064	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
228400002065	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
228400002066	ABC transporter; Region: ABC_tran_2; pfam12848
228400002067	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
228400002068	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
228400002069	ABC transporter signature motif; other site
228400002070	Walker B; other site
228400002071	D-loop; other site
228400002072	H-loop/switch region; other site
228400002073	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
228400002074	Predicted transcriptional regulator [Transcription]; Region: COG2932
228400002075	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
228400002076	Catalytic site [active]
228400002077	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
228400002078	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
228400002079	putative transposase OrfB; Reviewed; Region: PHA02517
228400002080	Integrase core domain; Region: rve; pfam00665
228400002081	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
228400002082	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
228400002083	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400002084	non-specific DNA binding site [nucleotide binding]; other site
228400002085	salt bridge; other site
228400002086	sequence-specific DNA binding site [nucleotide binding]; other site
228400002087	HTH domain; Region: HTH_11; cl17392
228400002088	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
228400002089	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
228400002090	Mor transcription activator family; Region: Mor; cl02360
228400002091	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
228400002092	amidase catalytic site [active]
228400002093	Zn binding residues [ion binding]; other site
228400002094	substrate binding site [chemical binding]; other site
228400002095	Protein of unknown function (DUF2644); Region: DUF2644; pfam10841
228400002096	Protein of unknown function (DUF2681); Region: DUF2681; pfam10883
228400002097	Protein of unknown function (DUF1804); Region: DUF1804; pfam08822
228400002098	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
228400002099	Protein of unknown function (DUF935); Region: DUF935; pfam06074
228400002100	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
228400002101	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
228400002102	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
228400002103	Mu-like prophage protein gpG [General function prediction only]; Region: COG5005
228400002104	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
228400002105	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
228400002106	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
228400002107	Domain of unknown function (DUF1834); Region: DUF1834; pfam08873
228400002108	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
228400002109	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
228400002110	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
228400002111	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
228400002112	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
228400002113	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
228400002114	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
228400002115	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
228400002116	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
228400002117	Phage protein GP46; Region: GP46; cl01814
228400002118	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
228400002119	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
228400002120	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
228400002121	Phage Tail Collar Domain; Region: Collar; pfam07484
228400002122	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
228400002123	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
228400002124	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
228400002125	cofactor binding site; other site
228400002126	substrate interaction site [chemical binding]; other site
228400002127	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
228400002128	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
228400002129	Walker A/P-loop; other site
228400002130	ATP binding site [chemical binding]; other site
228400002131	Q-loop/lid; other site
228400002132	ABC transporter signature motif; other site
228400002133	Walker B; other site
228400002134	D-loop; other site
228400002135	H-loop/switch region; other site
228400002136	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
228400002137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400002138	Walker A/P-loop; other site
228400002139	ATP binding site [chemical binding]; other site
228400002140	Q-loop/lid; other site
228400002141	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
228400002142	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
228400002143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400002144	dimer interface [polypeptide binding]; other site
228400002145	conserved gate region; other site
228400002146	ABC-ATPase subunit interface; other site
228400002147	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
228400002148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400002149	dimer interface [polypeptide binding]; other site
228400002150	conserved gate region; other site
228400002151	putative PBP binding loops; other site
228400002152	ABC-ATPase subunit interface; other site
228400002153	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
228400002154	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
228400002155	peptide binding site [polypeptide binding]; other site
228400002156	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
228400002157	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
228400002158	peptide binding site [polypeptide binding]; other site
228400002159	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
228400002160	TrkA-N domain; Region: TrkA_N; pfam02254
228400002161	TrkA-C domain; Region: TrkA_C; pfam02080
228400002162	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
228400002163	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
228400002164	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
228400002165	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
228400002166	nucleotide binding pocket [chemical binding]; other site
228400002167	K-X-D-G motif; other site
228400002168	catalytic site [active]
228400002169	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
228400002170	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
228400002171	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
228400002172	Dimer interface [polypeptide binding]; other site
228400002173	BRCT sequence motif; other site
228400002174	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
228400002175	fructuronate transporter; Provisional; Region: PRK10034; cl15264
228400002176	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
228400002177	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
228400002178	NADP binding site [chemical binding]; other site
228400002179	homodimer interface [polypeptide binding]; other site
228400002180	active site
228400002181	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
228400002182	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
228400002183	putative NAD(P) binding site [chemical binding]; other site
228400002184	catalytic Zn binding site [ion binding]; other site
228400002185	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
228400002186	ATP-binding site [chemical binding]; other site
228400002187	Gluconate-6-phosphate binding site [chemical binding]; other site
228400002188	Shikimate kinase; Region: SKI; pfam01202
228400002189	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
228400002190	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
228400002191	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
228400002192	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
228400002193	DctM-like transporters; Region: DctM; pfam06808
228400002194	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400002195	trimer interface [polypeptide binding]; other site
228400002196	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400002197	trimer interface [polypeptide binding]; other site
228400002198	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400002199	trimer interface [polypeptide binding]; other site
228400002200	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400002201	trimer interface [polypeptide binding]; other site
228400002202	YadA-like C-terminal region; Region: YadA; pfam03895
228400002203	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
228400002204	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
228400002205	G1 box; other site
228400002206	putative GEF interaction site [polypeptide binding]; other site
228400002207	GTP/Mg2+ binding site [chemical binding]; other site
228400002208	Switch I region; other site
228400002209	G2 box; other site
228400002210	G3 box; other site
228400002211	Switch II region; other site
228400002212	G4 box; other site
228400002213	G5 box; other site
228400002214	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
228400002215	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
228400002216	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
228400002217	putative acyl-acceptor binding pocket; other site
228400002218	LexA repressor; Validated; Region: PRK00215
228400002219	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
228400002220	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
228400002221	Catalytic site [active]
228400002222	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
228400002223	active site
228400002224	multimer interface [polypeptide binding]; other site
228400002225	aminopeptidase B; Provisional; Region: PRK05015
228400002226	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
228400002227	interface (dimer of trimers) [polypeptide binding]; other site
228400002228	Substrate-binding/catalytic site; other site
228400002229	Zn-binding sites [ion binding]; other site
228400002230	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
228400002231	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
228400002232	substrate binding site [chemical binding]; other site
228400002233	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
228400002234	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
228400002235	substrate binding site [chemical binding]; other site
228400002236	ligand binding site [chemical binding]; other site
228400002237	tartrate dehydrogenase; Region: TTC; TIGR02089
228400002238	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
228400002239	2-isopropylmalate synthase; Validated; Region: PRK00915
228400002240	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
228400002241	active site
228400002242	catalytic residues [active]
228400002243	metal binding site [ion binding]; metal-binding site
228400002244	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
228400002245	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
228400002246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400002247	Walker A/P-loop; other site
228400002248	ATP binding site [chemical binding]; other site
228400002249	Q-loop/lid; other site
228400002250	ABC transporter signature motif; other site
228400002251	Walker B; other site
228400002252	D-loop; other site
228400002253	H-loop/switch region; other site
228400002254	heme exporter protein CcmB; Region: ccmB; TIGR01190
228400002255	heme exporter protein CcmC; Region: ccmC; TIGR01191
228400002256	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
228400002257	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
228400002258	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
228400002259	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
228400002260	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
228400002261	catalytic residues [active]
228400002262	central insert; other site
228400002263	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
228400002264	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
228400002265	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
228400002266	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
228400002267	TPR motif; other site
228400002268	binding surface
228400002269	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
228400002270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
228400002271	dimer interface [polypeptide binding]; other site
228400002272	phosphorylation site [posttranslational modification]
228400002273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
228400002274	ATP binding site [chemical binding]; other site
228400002275	Mg2+ binding site [ion binding]; other site
228400002276	G-X-G motif; other site
228400002277	Response regulator receiver domain; Region: Response_reg; pfam00072
228400002278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
228400002279	active site
228400002280	phosphorylation site [posttranslational modification]
228400002281	intermolecular recognition site; other site
228400002282	dimerization interface [polypeptide binding]; other site
228400002283	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
228400002284	putative binding surface; other site
228400002285	active site
228400002286	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
228400002287	Helix-turn-helix domain; Region: HTH_25; pfam13413
228400002288	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
228400002289	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
228400002290	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
228400002291	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
228400002292	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
228400002293	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
228400002294	dimer interface [polypeptide binding]; other site
228400002295	motif 1; other site
228400002296	active site
228400002297	motif 2; other site
228400002298	motif 3; other site
228400002299	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
228400002300	anticodon binding site; other site
228400002301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
228400002302	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
228400002303	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
228400002304	binding surface
228400002305	TPR motif; other site
228400002306	succinic semialdehyde dehydrogenase; Region: PLN02278
228400002307	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
228400002308	tetramerization interface [polypeptide binding]; other site
228400002309	NAD(P) binding site [chemical binding]; other site
228400002310	catalytic residues [active]
228400002311	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
228400002312	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
228400002313	putative catalytic cysteine [active]
228400002314	Predicted membrane protein [Function unknown]; Region: COG2860
228400002315	UPF0126 domain; Region: UPF0126; pfam03458
228400002316	UPF0126 domain; Region: UPF0126; pfam03458
228400002317	thymidine kinase; Provisional; Region: PRK04296
228400002318	UGMP family protein; Validated; Region: PRK09604
228400002319	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
228400002320	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
228400002321	DNA protecting protein DprA; Region: dprA; TIGR00732
228400002322	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
228400002323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400002324	S-adenosylmethionine binding site [chemical binding]; other site
228400002325	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
228400002326	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
228400002327	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
228400002328	P loop; other site
228400002329	GTP binding site [chemical binding]; other site
228400002330	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
228400002331	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
228400002332	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
228400002333	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
228400002334	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
228400002335	G1 box; other site
228400002336	putative GEF interaction site [polypeptide binding]; other site
228400002337	GTP/Mg2+ binding site [chemical binding]; other site
228400002338	Switch I region; other site
228400002339	G2 box; other site
228400002340	G3 box; other site
228400002341	Switch II region; other site
228400002342	G4 box; other site
228400002343	G5 box; other site
228400002344	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
228400002345	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
228400002346	glutamine synthetase; Provisional; Region: glnA; PRK09469
228400002347	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
228400002348	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
228400002349	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
228400002350	HTH domain; Region: HTH_11; cl17392
228400002351	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
228400002352	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
228400002353	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
228400002354	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
228400002355	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
228400002356	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
228400002357	active site
228400002358	GMP synthase; Reviewed; Region: guaA; PRK00074
228400002359	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
228400002360	AMP/PPi binding site [chemical binding]; other site
228400002361	candidate oxyanion hole; other site
228400002362	catalytic triad [active]
228400002363	potential glutamine specificity residues [chemical binding]; other site
228400002364	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
228400002365	ATP Binding subdomain [chemical binding]; other site
228400002366	Ligand Binding sites [chemical binding]; other site
228400002367	Dimerization subdomain; other site
228400002368	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
228400002369	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
228400002370	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
228400002371	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
228400002372	TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776
228400002373	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
228400002374	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
228400002375	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
228400002376	heat shock protein 90; Provisional; Region: PRK05218
228400002377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
228400002378	ATP binding site [chemical binding]; other site
228400002379	Mg2+ binding site [ion binding]; other site
228400002380	G-X-G motif; other site
228400002381	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
228400002382	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
228400002383	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
228400002384	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
228400002385	active site
228400002386	HIGH motif; other site
228400002387	KMSKS motif; other site
228400002388	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
228400002389	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
228400002390	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
228400002391	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
228400002392	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
228400002393	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
228400002394	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
228400002395	CoA-binding site [chemical binding]; other site
228400002396	ATP-binding [chemical binding]; other site
228400002397	Domain of unknown function (DUF329); Region: DUF329; pfam03884
228400002398	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
228400002399	amino acid carrier protein; Region: agcS; TIGR00835
228400002400	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
228400002401	30S subunit binding site; other site
228400002402	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
228400002403	active site
228400002404	superoxide dismutase; Provisional; Region: PRK10925
228400002405	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
228400002406	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
228400002407	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
228400002408	Malic enzyme, N-terminal domain; Region: malic; pfam00390
228400002409	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
228400002410	putative NAD(P) binding site [chemical binding]; other site
228400002411	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
228400002412	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
228400002413	Aspartase; Region: Aspartase; cd01357
228400002414	active sites [active]
228400002415	tetramer interface [polypeptide binding]; other site
228400002416	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
228400002417	oligomerisation interface [polypeptide binding]; other site
228400002418	mobile loop; other site
228400002419	roof hairpin; other site
228400002420	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
228400002421	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
228400002422	ring oligomerisation interface [polypeptide binding]; other site
228400002423	ATP/Mg binding site [chemical binding]; other site
228400002424	stacking interactions; other site
228400002425	hinge regions; other site
228400002426	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
228400002427	dimerization interface [polypeptide binding]; other site
228400002428	DNA binding site [nucleotide binding]
228400002429	corepressor binding sites; other site
228400002430	Der GTPase activator; Provisional; Region: PRK05244
228400002431	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
228400002432	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
228400002433	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400002434	FeS/SAM binding site; other site
228400002435	HemN C-terminal domain; Region: HemN_C; pfam06969
228400002436	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
228400002437	SmpB-tmRNA interface; other site
228400002438	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
228400002439	cystathionine beta-lyase; Provisional; Region: PRK08114
228400002440	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
228400002441	homodimer interface [polypeptide binding]; other site
228400002442	substrate-cofactor binding pocket; other site
228400002443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400002444	catalytic residue [active]
228400002445	peroxidase; Provisional; Region: PRK15000
228400002446	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
228400002447	dimer interface [polypeptide binding]; other site
228400002448	decamer (pentamer of dimers) interface [polypeptide binding]; other site
228400002449	catalytic triad [active]
228400002450	peroxidatic and resolving cysteines [active]
228400002451	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
228400002452	16S/18S rRNA binding site [nucleotide binding]; other site
228400002453	S13e-L30e interaction site [polypeptide binding]; other site
228400002454	25S rRNA binding site [nucleotide binding]; other site
228400002455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400002456	Major Facilitator Superfamily; Region: MFS_1; pfam07690
228400002457	putative substrate translocation pore; other site
228400002458	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
228400002459	Iron-sulfur protein interface; other site
228400002460	proximal quinone binding site [chemical binding]; other site
228400002461	C-subunit interface; other site
228400002462	distal quinone binding site; other site
228400002463	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
228400002464	D-subunit interface [polypeptide binding]; other site
228400002465	Iron-sulfur protein interface; other site
228400002466	proximal quinone binding site [chemical binding]; other site
228400002467	distal quinone binding site [chemical binding]; other site
228400002468	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
228400002469	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
228400002470	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
228400002471	L-aspartate oxidase; Provisional; Region: PRK06175
228400002472	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
228400002473	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
228400002474	poxB regulator PoxA; Provisional; Region: PRK09350
228400002475	motif 1; other site
228400002476	dimer interface [polypeptide binding]; other site
228400002477	active site
228400002478	motif 2; other site
228400002479	motif 3; other site
228400002480	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
228400002481	L-aspartate oxidase; Provisional; Region: PRK06175
228400002482	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
228400002483	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
228400002484	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
228400002485	Walker A/P-loop; other site
228400002486	ATP binding site [chemical binding]; other site
228400002487	Q-loop/lid; other site
228400002488	ABC transporter signature motif; other site
228400002489	Walker B; other site
228400002490	D-loop; other site
228400002491	H-loop/switch region; other site
228400002492	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
228400002493	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
228400002494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400002495	dimer interface [polypeptide binding]; other site
228400002496	conserved gate region; other site
228400002497	putative PBP binding loops; other site
228400002498	ABC-ATPase subunit interface; other site
228400002499	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
228400002500	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
228400002501	Walker A/P-loop; other site
228400002502	ATP binding site [chemical binding]; other site
228400002503	Q-loop/lid; other site
228400002504	ABC transporter signature motif; other site
228400002505	Walker B; other site
228400002506	D-loop; other site
228400002507	H-loop/switch region; other site
228400002508	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
228400002509	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
228400002510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400002511	dimer interface [polypeptide binding]; other site
228400002512	conserved gate region; other site
228400002513	putative PBP binding loops; other site
228400002514	ABC-ATPase subunit interface; other site
228400002515	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
228400002516	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
228400002517	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
228400002518	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
228400002519	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
228400002520	substrate binding site [chemical binding]; other site
228400002521	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
228400002522	substrate binding site [chemical binding]; other site
228400002523	ligand binding site [chemical binding]; other site
228400002524	YciI-like protein; Reviewed; Region: PRK11370
228400002525	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
228400002526	intracellular septation protein A; Reviewed; Region: PRK00259
228400002527	DNA polymerase III subunit chi; Validated; Region: PRK05728
228400002528	Fic family protein [Function unknown]; Region: COG3177
228400002529	Fic/DOC family; Region: Fic; pfam02661
228400002530	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
228400002531	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
228400002532	cofactor binding site; other site
228400002533	DNA binding site [nucleotide binding]
228400002534	substrate interaction site [chemical binding]; other site
228400002535	R.HinP1I restriction endonuclease; Region: R-HINP1I; pfam11463
228400002536	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
228400002537	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
228400002538	HIGH motif; other site
228400002539	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
228400002540	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
228400002541	active site
228400002542	KMSKS motif; other site
228400002543	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
228400002544	tRNA binding surface [nucleotide binding]; other site
228400002545	anticodon binding site; other site
228400002546	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
228400002547	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
228400002548	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
228400002549	dimerization interface 3.5A [polypeptide binding]; other site
228400002550	active site
228400002551	cytidine deaminase; Provisional; Region: PRK09027
228400002552	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
228400002553	active site
228400002554	catalytic motif [active]
228400002555	Zn binding site [ion binding]; other site
228400002556	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
228400002557	active site
228400002558	catalytic motif [active]
228400002559	Zn binding site [ion binding]; other site
228400002560	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
228400002561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
228400002562	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
228400002563	dimerization interface [polypeptide binding]; other site
228400002564	Coenzyme A transferase; Region: CoA_trans; cl17247
228400002565	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
228400002566	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
228400002567	putative acyltransferase; Provisional; Region: PRK05790
228400002568	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
228400002569	dimer interface [polypeptide binding]; other site
228400002570	active site
228400002571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
228400002572	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
228400002573	NAD(P) binding site [chemical binding]; other site
228400002574	active site
228400002575	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
228400002576	fructuronate transporter; Provisional; Region: PRK10034; cl15264
228400002577	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
228400002578	intersubunit interface [polypeptide binding]; other site
228400002579	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
228400002580	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
228400002581	metal binding site [ion binding]; metal-binding site
228400002582	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
228400002583	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
228400002584	putative ATP binding site [chemical binding]; other site
228400002585	putative substrate interface [chemical binding]; other site
228400002586	murein transglycosylase A; Provisional; Region: mltA; PRK11162
228400002587	MltA specific insert domain; Region: MltA; smart00925
228400002588	3D domain; Region: 3D; pfam06725
228400002589	fructokinase; Reviewed; Region: PRK09557
228400002590	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
228400002591	nucleotide binding site [chemical binding]; other site
228400002592	Acetokinase family; Region: Acetate_kinase; cl17229
228400002593	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
228400002594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
228400002595	active site
228400002596	phosphorylation site [posttranslational modification]
228400002597	intermolecular recognition site; other site
228400002598	dimerization interface [polypeptide binding]; other site
228400002599	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
228400002600	DNA binding site [nucleotide binding]
228400002601	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
228400002602	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
228400002603	substrate binding site [chemical binding]; other site
228400002604	ATP binding site [chemical binding]; other site
228400002605	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
228400002606	intersubunit interface [polypeptide binding]; other site
228400002607	active site
228400002608	zinc binding site [ion binding]; other site
228400002609	Na+ binding site [ion binding]; other site
228400002610	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
228400002611	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
228400002612	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
228400002613	putative ligand binding site [chemical binding]; other site
228400002614	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400002615	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400002616	TM-ABC transporter signature motif; other site
228400002617	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
228400002618	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400002619	Walker A/P-loop; other site
228400002620	ATP binding site [chemical binding]; other site
228400002621	Q-loop/lid; other site
228400002622	ABC transporter signature motif; other site
228400002623	Walker B; other site
228400002624	D-loop; other site
228400002625	H-loop/switch region; other site
228400002626	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400002627	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
228400002628	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
228400002629	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
228400002630	dimer interface [polypeptide binding]; other site
228400002631	phosphorylation site [posttranslational modification]
228400002632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
228400002633	ATP binding site [chemical binding]; other site
228400002634	Mg2+ binding site [ion binding]; other site
228400002635	G-X-G motif; other site
228400002636	Response regulator receiver domain; Region: Response_reg; pfam00072
228400002637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
228400002638	active site
228400002639	phosphorylation site [posttranslational modification]
228400002640	intermolecular recognition site; other site
228400002641	dimerization interface [polypeptide binding]; other site
228400002642	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
228400002643	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
228400002644	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
228400002645	active site
228400002646	P-loop; other site
228400002647	phosphorylation site [posttranslational modification]
228400002648	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
228400002649	active site
228400002650	phosphorylation site [posttranslational modification]
228400002651	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
228400002652	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
228400002653	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
228400002654	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
228400002655	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
228400002656	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
228400002657	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
228400002658	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
228400002659	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
228400002660	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
228400002661	AMP binding site [chemical binding]; other site
228400002662	metal binding site [ion binding]; metal-binding site
228400002663	active site
228400002664	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
228400002665	active site pocket [active]
228400002666	oxyanion hole [active]
228400002667	catalytic triad [active]
228400002668	active site nucleophile [active]
228400002669	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
228400002670	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
228400002671	GTP-binding protein LepA; Provisional; Region: PRK05433
228400002672	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
228400002673	G1 box; other site
228400002674	putative GEF interaction site [polypeptide binding]; other site
228400002675	GTP/Mg2+ binding site [chemical binding]; other site
228400002676	Switch I region; other site
228400002677	G2 box; other site
228400002678	G3 box; other site
228400002679	Switch II region; other site
228400002680	G4 box; other site
228400002681	G5 box; other site
228400002682	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
228400002683	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
228400002684	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
228400002685	signal peptidase I; Provisional; Region: PRK10861
228400002686	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
228400002687	Catalytic site [active]
228400002688	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
228400002689	ribonuclease III; Reviewed; Region: rnc; PRK00102
228400002690	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
228400002691	dimerization interface [polypeptide binding]; other site
228400002692	active site
228400002693	metal binding site [ion binding]; metal-binding site
228400002694	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
228400002695	dsRNA binding site [nucleotide binding]; other site
228400002696	GTPase Era; Reviewed; Region: era; PRK00089
228400002697	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
228400002698	G1 box; other site
228400002699	GTP/Mg2+ binding site [chemical binding]; other site
228400002700	Switch I region; other site
228400002701	G2 box; other site
228400002702	Switch II region; other site
228400002703	G3 box; other site
228400002704	G4 box; other site
228400002705	G5 box; other site
228400002706	KH domain; Region: KH_2; pfam07650
228400002707	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
228400002708	dimer interface [polypeptide binding]; other site
228400002709	active site
228400002710	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
228400002711	DNA primase; Validated; Region: dnaG; PRK05667
228400002712	CHC2 zinc finger; Region: zf-CHC2; pfam01807
228400002713	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
228400002714	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
228400002715	active site
228400002716	metal binding site [ion binding]; metal-binding site
228400002717	interdomain interaction site; other site
228400002718	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
228400002719	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
228400002720	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
228400002721	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
228400002722	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
228400002723	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
228400002724	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
228400002725	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
228400002726	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
228400002727	DNA binding residues [nucleotide binding]
228400002728	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400002729	trimer interface [polypeptide binding]; other site
228400002730	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400002731	trimer interface [polypeptide binding]; other site
228400002732	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400002733	trimer interface [polypeptide binding]; other site
228400002734	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400002735	trimer interface [polypeptide binding]; other site
228400002736	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400002737	trimer interface [polypeptide binding]; other site
228400002738	YadA-like C-terminal region; Region: YadA; pfam03895
228400002739	hypothetical protein; Provisional; Region: PRK11111
228400002740	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
228400002741	dimer interface [polypeptide binding]; other site
228400002742	motif 1; other site
228400002743	active site
228400002744	motif 2; other site
228400002745	motif 3; other site
228400002746	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
228400002747	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
228400002748	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
228400002749	inhibitor-cofactor binding pocket; inhibition site
228400002750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400002751	catalytic residue [active]
228400002752	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
228400002753	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
228400002754	DNA binding site [nucleotide binding]
228400002755	active site
228400002756	Int/Topo IB signature motif; other site
228400002757	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
228400002758	methionine synthase; Provisional; Region: PRK01207
228400002759	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
228400002760	substrate binding site [chemical binding]; other site
228400002761	THF binding site; other site
228400002762	zinc-binding site [ion binding]; other site
228400002763	Flavin Reductases; Region: FlaRed; cl00801
228400002764	Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306
228400002765	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
228400002766	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
228400002767	dimer interface [polypeptide binding]; other site
228400002768	anticodon binding site; other site
228400002769	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
228400002770	homodimer interface [polypeptide binding]; other site
228400002771	motif 1; other site
228400002772	active site
228400002773	motif 2; other site
228400002774	GAD domain; Region: GAD; pfam02938
228400002775	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
228400002776	active site
228400002777	motif 3; other site
228400002778	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400002779	S-adenosylmethionine binding site [chemical binding]; other site
228400002780	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
228400002781	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
228400002782	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
228400002783	homodimer interface [polypeptide binding]; other site
228400002784	NADP binding site [chemical binding]; other site
228400002785	substrate binding site [chemical binding]; other site
228400002786	integrase; Provisional; Region: int; PHA02601
228400002787	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
228400002788	active site
228400002789	DNA binding site [nucleotide binding]
228400002790	Int/Topo IB signature motif; other site
228400002791	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
228400002792	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
228400002793	cofactor binding site; other site
228400002794	DNA binding site [nucleotide binding]
228400002795	substrate interaction site [chemical binding]; other site
228400002796	Protein of unknown function (DUF551); Region: DUF551; pfam04448
228400002797	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
228400002798	putative trimer interface [polypeptide binding]; other site
228400002799	putative CoA binding site [chemical binding]; other site
228400002800	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
228400002801	active site
228400002802	catalytic site [active]
228400002803	substrate binding site [chemical binding]; other site
228400002804	Fungal trichothecene efflux pump (TRI12); Region: TRI12; pfam06609
228400002805	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
228400002806	Protein of unknown function, DUF258; Region: DUF258; pfam03193
228400002807	AAA domain; Region: AAA_22; pfam13401
228400002808	KilA-N domain; Region: KilA-N; pfam04383
228400002809	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
228400002810	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
228400002811	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
228400002812	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400002813	non-specific DNA binding site [nucleotide binding]; other site
228400002814	sequence-specific DNA binding site [nucleotide binding]; other site
228400002815	salt bridge; other site
228400002816	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400002817	non-specific DNA binding site [nucleotide binding]; other site
228400002818	salt bridge; other site
228400002819	sequence-specific DNA binding site [nucleotide binding]; other site
228400002820	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
228400002821	Catalytic site [active]
228400002822	Helix-turn-helix domain; Region: HTH_17; cl17695
228400002823	Helix-turn-helix domain; Region: HTH_39; pfam14090
228400002824	Replication protein P; Region: Phage_lambda_P; pfam06992
228400002825	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
228400002826	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
228400002827	Prophage antirepressor [Transcription]; Region: COG3617
228400002828	BRO family, N-terminal domain; Region: Bro-N; smart01040
228400002829	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
228400002830	YcfA-like protein; Region: YcfA; pfam07927
228400002831	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
228400002832	PemK-like protein; Region: PemK; cl00995
228400002833	lysine transporter; Provisional; Region: PRK10836
228400002834	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
228400002835	catalytic residues [active]
228400002836	Protein of unknown function (DUF2570); Region: DUF2570; pfam10828
228400002837	Bacterial type III secretion protein (HrpB2); Region: HrpB2; cl09721
228400002838	Phage terminase large subunit; Region: Terminase_3; cl12054
228400002839	ORF11CD3 domain; Region: ORF11CD3; pfam10549
228400002840	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
228400002841	P22AR C-terminal domain; Region: P22_AR_C; pfam10548
228400002842	Helix-turn-helix domain; Region: HTH_37; pfam13744
228400002843	non-specific DNA binding site [nucleotide binding]; other site
228400002844	salt bridge; other site
228400002845	sequence-specific DNA binding site [nucleotide binding]; other site
228400002846	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400002847	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
228400002848	non-specific DNA binding site [nucleotide binding]; other site
228400002849	salt bridge; other site
228400002850	sequence-specific DNA binding site [nucleotide binding]; other site
228400002851	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
228400002852	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
228400002853	lipoprotein NlpI; Provisional; Region: PRK11189
228400002854	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
228400002855	Protein of unknown function (DUF935); Region: DUF935; pfam06074
228400002856	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
228400002857	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
228400002858	putative acyl-acceptor binding pocket; other site
228400002859	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
228400002860	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
228400002861	putative ribose interaction site [chemical binding]; other site
228400002862	putative ADP binding site [chemical binding]; other site
228400002863	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
228400002864	active site
228400002865	HIGH motif; other site
228400002866	nucleotide binding site [chemical binding]; other site
228400002867	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
228400002868	ArsC family; Region: ArsC; pfam03960
228400002869	putative catalytic residues [active]
228400002870	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
228400002871	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
228400002872	metal binding site [ion binding]; metal-binding site
228400002873	dimer interface [polypeptide binding]; other site
228400002874	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
228400002875	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
228400002876	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
228400002877	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
228400002878	dimer interface [polypeptide binding]; other site
228400002879	ADP-ribose binding site [chemical binding]; other site
228400002880	active site
228400002881	nudix motif; other site
228400002882	metal binding site [ion binding]; metal-binding site
228400002883	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
228400002884	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
228400002885	active site
228400002886	metal binding site [ion binding]; metal-binding site
228400002887	hexamer interface [polypeptide binding]; other site
228400002888	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
228400002889	ligand-binding site [chemical binding]; other site
228400002890	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
228400002891	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400002892	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400002893	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400002894	TM-ABC transporter signature motif; other site
228400002895	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
228400002896	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400002897	Walker A/P-loop; other site
228400002898	ATP binding site [chemical binding]; other site
228400002899	Q-loop/lid; other site
228400002900	ABC transporter signature motif; other site
228400002901	Walker B; other site
228400002902	D-loop; other site
228400002903	H-loop/switch region; other site
228400002904	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400002905	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
228400002906	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
228400002907	putative ligand binding site [chemical binding]; other site
228400002908	xylose isomerase; Provisional; Region: PRK05474
228400002909	xylose isomerase; Region: xylose_isom_A; TIGR02630
228400002910	xylulokinase; Provisional; Region: PRK15027
228400002911	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
228400002912	N- and C-terminal domain interface [polypeptide binding]; other site
228400002913	active site
228400002914	MgATP binding site [chemical binding]; other site
228400002915	catalytic site [active]
228400002916	metal binding site [ion binding]; metal-binding site
228400002917	xylulose binding site [chemical binding]; other site
228400002918	homodimer interface [polypeptide binding]; other site
228400002919	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400002920	trimer interface [polypeptide binding]; other site
228400002921	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
228400002922	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
228400002923	Walker A/P-loop; other site
228400002924	ATP binding site [chemical binding]; other site
228400002925	Q-loop/lid; other site
228400002926	ABC transporter signature motif; other site
228400002927	Walker B; other site
228400002928	D-loop; other site
228400002929	H-loop/switch region; other site
228400002930	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
228400002931	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
228400002932	Walker A/P-loop; other site
228400002933	ATP binding site [chemical binding]; other site
228400002934	Q-loop/lid; other site
228400002935	ABC transporter signature motif; other site
228400002936	Walker B; other site
228400002937	D-loop; other site
228400002938	H-loop/switch region; other site
228400002939	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
228400002940	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
228400002941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400002942	putative PBP binding loops; other site
228400002943	ABC-ATPase subunit interface; other site
228400002944	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
228400002945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400002946	dimer interface [polypeptide binding]; other site
228400002947	conserved gate region; other site
228400002948	putative PBP binding loops; other site
228400002949	ABC-ATPase subunit interface; other site
228400002950	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
228400002951	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
228400002952	peptide binding site [polypeptide binding]; other site
228400002953	YcjX-like family, DUF463; Region: DUF463; pfam04317
228400002954	hypothetical protein; Provisional; Region: PRK05415
228400002955	Domain of unknown function (DUF697); Region: DUF697; cl12064
228400002956	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
228400002957	GSH binding site [chemical binding]; other site
228400002958	catalytic residues [active]
228400002959	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
228400002960	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
228400002961	CAP-like domain; other site
228400002962	active site
228400002963	primary dimer interface [polypeptide binding]; other site
228400002964	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
228400002965	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
228400002966	HNH endonuclease; Region: HNH_2; pfam13391
228400002967	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
228400002968	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
228400002969	cofactor binding site; other site
228400002970	DNA binding site [nucleotide binding]
228400002971	substrate interaction site [chemical binding]; other site
228400002972	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
228400002973	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
228400002974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
228400002975	ATP binding site [chemical binding]; other site
228400002976	Mg2+ binding site [ion binding]; other site
228400002977	G-X-G motif; other site
228400002978	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
228400002979	anchoring element; other site
228400002980	dimer interface [polypeptide binding]; other site
228400002981	ATP binding site [chemical binding]; other site
228400002982	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
228400002983	active site
228400002984	putative metal-binding site [ion binding]; other site
228400002985	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
228400002986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400002987	muropeptide transporter; Reviewed; Region: ampG; PRK11902
228400002988	putative substrate translocation pore; other site
228400002989	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
228400002990	Sulfate transporter family; Region: Sulfate_transp; pfam00916
228400002991	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400002992	trimer interface [polypeptide binding]; other site
228400002993	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400002994	trimer interface [polypeptide binding]; other site
228400002995	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
228400002996	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
228400002997	active site
228400002998	catalytic site [active]
228400002999	substrate binding site [chemical binding]; other site
228400003000	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
228400003001	RNA/DNA hybrid binding site [nucleotide binding]; other site
228400003002	active site
228400003003	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
228400003004	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
228400003005	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
228400003006	Protein of unknown function (DUF986); Region: DUF986; cl01983
228400003007	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
228400003008	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
228400003009	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
228400003010	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
228400003011	active pocket/dimerization site; other site
228400003012	active site
228400003013	phosphorylation site [posttranslational modification]
228400003014	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
228400003015	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
228400003016	active site
228400003017	phosphorylation site [posttranslational modification]
228400003018	hypothetical protein; Provisional; Region: PRK05423
228400003019	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
228400003020	homodimer interface [polypeptide binding]; other site
228400003021	substrate-cofactor binding pocket; other site
228400003022	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400003023	catalytic residue [active]
228400003024	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
228400003025	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
228400003026	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400003027	homodimer interface [polypeptide binding]; other site
228400003028	catalytic residue [active]
228400003029	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
228400003030	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
228400003031	hinge; other site
228400003032	active site
228400003033	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
228400003034	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
228400003035	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
228400003036	HlyD family secretion protein; Region: HlyD_3; pfam13437
228400003037	multidrug efflux protein; Reviewed; Region: PRK09579
228400003038	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
228400003039	Putative serine esterase (DUF676); Region: DUF676; pfam05057
228400003040	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
228400003041	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
228400003042	dimer interface [polypeptide binding]; other site
228400003043	tetramer interface [polypeptide binding]; other site
228400003044	PYR/PP interface [polypeptide binding]; other site
228400003045	TPP binding site [chemical binding]; other site
228400003046	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
228400003047	TPP-binding site; other site
228400003048	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
228400003049	chorismate binding enzyme; Region: Chorismate_bind; cl10555
228400003050	aminotransferase AlaT; Validated; Region: PRK09265
228400003051	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
228400003052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400003053	homodimer interface [polypeptide binding]; other site
228400003054	catalytic residue [active]
228400003055	fatty acid metabolism regulator; Provisional; Region: PRK04984
228400003056	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
228400003057	DNA-binding site [nucleotide binding]; DNA binding site
228400003058	FadR C-terminal domain; Region: FadR_C; pfam07840
228400003059	disulfide bond formation protein B; Provisional; Region: PRK01749
228400003060	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
228400003061	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
228400003062	active site
228400003063	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
228400003064	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
228400003065	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
228400003066	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
228400003067	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
228400003068	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
228400003069	Walker A/P-loop; other site
228400003070	ATP binding site [chemical binding]; other site
228400003071	Q-loop/lid; other site
228400003072	ABC transporter signature motif; other site
228400003073	Walker B; other site
228400003074	D-loop; other site
228400003075	H-loop/switch region; other site
228400003076	TOBE domain; Region: TOBE_2; pfam08402
228400003077	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
228400003078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400003079	dimer interface [polypeptide binding]; other site
228400003080	conserved gate region; other site
228400003081	putative PBP binding loops; other site
228400003082	ABC-ATPase subunit interface; other site
228400003083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400003084	dimer interface [polypeptide binding]; other site
228400003085	conserved gate region; other site
228400003086	putative PBP binding loops; other site
228400003087	ABC-ATPase subunit interface; other site
228400003088	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
228400003089	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
228400003090	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
228400003091	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
228400003092	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
228400003093	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
228400003094	Sugar specificity; other site
228400003095	Pyrimidine base specificity; other site
228400003096	ATP-binding site [chemical binding]; other site
228400003097	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
228400003098	trimer interface [polypeptide binding]; other site
228400003099	active site
228400003100	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
228400003101	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
228400003102	Sodium Bile acid symporter family; Region: SBF; pfam01758
228400003103	adenylate kinase; Reviewed; Region: adk; PRK00279
228400003104	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
228400003105	AMP-binding site [chemical binding]; other site
228400003106	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
228400003107	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
228400003108	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
228400003109	dimer interface [polypeptide binding]; other site
228400003110	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
228400003111	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
228400003112	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
228400003113	recombination and repair protein; Provisional; Region: PRK10869
228400003114	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
228400003115	Walker A/P-loop; other site
228400003116	ATP binding site [chemical binding]; other site
228400003117	Q-loop/lid; other site
228400003118	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
228400003119	ABC transporter signature motif; other site
228400003120	Walker B; other site
228400003121	D-loop; other site
228400003122	H-loop/switch region; other site
228400003123	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
228400003124	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
228400003125	homotrimer interaction site [polypeptide binding]; other site
228400003126	putative active site [active]
228400003127	YwiC-like protein; Region: YwiC; pfam14256
228400003128	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
228400003129	RimK-like ATP-grasp domain; Region: RimK; pfam08443
228400003130	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
228400003131	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
228400003132	Uncharacterized conserved protein [Function unknown]; Region: COG2835
228400003133	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
228400003134	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
228400003135	Ligand binding site; other site
228400003136	oligomer interface; other site
228400003137	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
228400003138	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
228400003139	GIY-YIG motif/motif A; other site
228400003140	active site
228400003141	catalytic site [active]
228400003142	putative DNA binding site [nucleotide binding]; other site
228400003143	metal binding site [ion binding]; metal-binding site
228400003144	UvrB/uvrC motif; Region: UVR; pfam02151
228400003145	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
228400003146	TM2 domain; Region: TM2; pfam05154
228400003147	exoribonuclease II; Provisional; Region: PRK05054
228400003148	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
228400003149	RNB domain; Region: RNB; pfam00773
228400003150	S1 RNA binding domain; Region: S1; pfam00575
228400003151	RNA binding site [nucleotide binding]; other site
228400003152	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
228400003153	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
228400003154	NAD binding site [chemical binding]; other site
228400003155	homotetramer interface [polypeptide binding]; other site
228400003156	homodimer interface [polypeptide binding]; other site
228400003157	substrate binding site [chemical binding]; other site
228400003158	active site
228400003159	Uncharacterized conserved protein [Function unknown]; Region: COG0327
228400003160	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
228400003161	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
228400003162	Uncharacterized conserved protein [Function unknown]; Region: COG4121
228400003163	hydroxyglutarate oxidase; Provisional; Region: PRK11728
228400003164	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
228400003165	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
228400003166	dimer interface [polypeptide binding]; other site
228400003167	active site
228400003168	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
228400003169	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
228400003170	catalytic site [active]
228400003171	putative active site [active]
228400003172	putative substrate binding site [chemical binding]; other site
228400003173	dimer interface [polypeptide binding]; other site
228400003174	GTPase RsgA; Reviewed; Region: PRK12288
228400003175	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
228400003176	RNA binding site [nucleotide binding]; other site
228400003177	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
228400003178	GTPase/Zn-binding domain interface [polypeptide binding]; other site
228400003179	GTP/Mg2+ binding site [chemical binding]; other site
228400003180	G4 box; other site
228400003181	G5 box; other site
228400003182	G1 box; other site
228400003183	Switch I region; other site
228400003184	G2 box; other site
228400003185	G3 box; other site
228400003186	Switch II region; other site
228400003187	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
228400003188	dimerization domain swap beta strand [polypeptide binding]; other site
228400003189	regulatory protein interface [polypeptide binding]; other site
228400003190	active site
228400003191	regulatory phosphorylation site [posttranslational modification]; other site
228400003192	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
228400003193	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
228400003194	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
228400003195	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
228400003196	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
228400003197	HPr interaction site; other site
228400003198	glycerol kinase (GK) interaction site [polypeptide binding]; other site
228400003199	active site
228400003200	phosphorylation site [posttranslational modification]
228400003201	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
228400003202	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
228400003203	dimer interface [polypeptide binding]; other site
228400003204	TPP-binding site [chemical binding]; other site
228400003205	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
228400003206	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
228400003207	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
228400003208	E3 interaction surface; other site
228400003209	lipoyl attachment site [posttranslational modification]; other site
228400003210	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
228400003211	E3 interaction surface; other site
228400003212	lipoyl attachment site [posttranslational modification]; other site
228400003213	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
228400003214	E3 interaction surface; other site
228400003215	lipoyl attachment site [posttranslational modification]; other site
228400003216	e3 binding domain; Region: E3_binding; pfam02817
228400003217	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
228400003218	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
228400003219	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
228400003220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
228400003221	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
228400003222	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
228400003223	Catalytic site [active]
228400003224	serine/threonine transporter SstT; Provisional; Region: PRK13628
228400003225	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
228400003226	Trp operon repressor; Provisional; Region: PRK01381
228400003227	elongation factor Ts; Provisional; Region: tsf; PRK09377
228400003228	UBA/TS-N domain; Region: UBA; pfam00627
228400003229	Elongation factor TS; Region: EF_TS; pfam00889
228400003230	Elongation factor TS; Region: EF_TS; pfam00889
228400003231	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
228400003232	rRNA interaction site [nucleotide binding]; other site
228400003233	S8 interaction site; other site
228400003234	putative laminin-1 binding site; other site
228400003235	periplasmic folding chaperone; Provisional; Region: PRK10788
228400003236	SurA N-terminal domain; Region: SurA_N_3; cl07813
228400003237	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
228400003238	pyruvate kinase; Provisional; Region: PRK05826
228400003239	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
228400003240	domain interfaces; other site
228400003241	active site
228400003242	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003243	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400003244	trimer interface [polypeptide binding]; other site
228400003245	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400003246	trimer interface [polypeptide binding]; other site
228400003247	Haemagglutinin; Region: HIM; pfam05662
228400003248	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003249	trimer interface [polypeptide binding]; other site
228400003250	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003251	trimer interface [polypeptide binding]; other site
228400003252	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003253	trimer interface [polypeptide binding]; other site
228400003254	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400003255	trimer interface [polypeptide binding]; other site
228400003256	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400003257	trimer interface [polypeptide binding]; other site
228400003258	YadA-like C-terminal region; Region: YadA; pfam03895
228400003259	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
228400003260	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
228400003261	dinuclear metal binding motif [ion binding]; other site
228400003262	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
228400003263	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
228400003264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400003265	Walker A/P-loop; other site
228400003266	ATP binding site [chemical binding]; other site
228400003267	Q-loop/lid; other site
228400003268	ABC transporter signature motif; other site
228400003269	Walker B; other site
228400003270	D-loop; other site
228400003271	H-loop/switch region; other site
228400003272	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
228400003273	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
228400003274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400003275	Walker A/P-loop; other site
228400003276	ATP binding site [chemical binding]; other site
228400003277	Q-loop/lid; other site
228400003278	ABC transporter signature motif; other site
228400003279	Walker B; other site
228400003280	D-loop; other site
228400003281	H-loop/switch region; other site
228400003282	thioredoxin reductase; Provisional; Region: PRK10262
228400003283	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
228400003284	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
228400003285	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
228400003286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400003287	FeS/SAM binding site; other site
228400003288	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858
228400003289	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
228400003290	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
228400003291	active site
228400003292	phosphorylation site [posttranslational modification]
228400003293	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
228400003294	active site
228400003295	P-loop; other site
228400003296	phosphorylation site [posttranslational modification]
228400003297	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
228400003298	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
228400003299	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
228400003300	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
228400003301	putative NAD(P) binding site [chemical binding]; other site
228400003302	catalytic Zn binding site [ion binding]; other site
228400003303	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
228400003304	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
228400003305	DNA-binding site [nucleotide binding]; DNA binding site
228400003306	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
228400003307	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
228400003308	Protein of unknown function (DUF692); Region: DUF692; pfam05114
228400003309	Predicted membrane protein [Function unknown]; Region: COG2259
228400003310	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
228400003311	Pyruvate formate lyase 1; Region: PFL1; cd01678
228400003312	coenzyme A binding site [chemical binding]; other site
228400003313	active site
228400003314	catalytic residues [active]
228400003315	glycine loop; other site
228400003316	formate transporter FocA; Region: formate_focA; TIGR04060
228400003317	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
228400003318	nucleotide binding site/active site [active]
228400003319	HIT family signature motif; other site
228400003320	catalytic residue [active]
228400003321	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
228400003322	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
228400003323	putative dimer interface [polypeptide binding]; other site
228400003324	beta-hexosaminidase; Provisional; Region: PRK05337
228400003325	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
228400003326	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
228400003327	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
228400003328	FAD binding site [chemical binding]; other site
228400003329	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
228400003330	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
228400003331	dimer interface [polypeptide binding]; other site
228400003332	ssDNA binding site [nucleotide binding]; other site
228400003333	tetramer (dimer of dimers) interface [polypeptide binding]; other site
228400003334	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
228400003335	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
228400003336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400003337	ABC transporter signature motif; other site
228400003338	Walker B; other site
228400003339	D-loop; other site
228400003340	H-loop/switch region; other site
228400003341	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
228400003342	rod shape-determining protein MreB; Provisional; Region: PRK13927
228400003343	MreB and similar proteins; Region: MreB_like; cd10225
228400003344	nucleotide binding site [chemical binding]; other site
228400003345	Mg binding site [ion binding]; other site
228400003346	putative protofilament interaction site [polypeptide binding]; other site
228400003347	RodZ interaction site [polypeptide binding]; other site
228400003348	rod shape-determining protein MreC; Region: mreC; TIGR00219
228400003349	rod shape-determining protein MreC; Region: MreC; pfam04085
228400003350	rod shape-determining protein MreD; Region: MreD; cl01087
228400003351	cell division protein FtsN; Provisional; Region: PRK12757
228400003352	Sporulation related domain; Region: SPOR; cl10051
228400003353	Sporulation related domain; Region: SPOR; cl10051
228400003354	primosome assembly protein PriA; Validated; Region: PRK05580
228400003355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400003356	ATP binding site [chemical binding]; other site
228400003357	putative Mg++ binding site [ion binding]; other site
228400003358	helicase superfamily c-terminal domain; Region: HELICc; smart00490
228400003359	nucleotide binding region [chemical binding]; other site
228400003360	ATP-binding site [chemical binding]; other site
228400003361	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
228400003362	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
228400003363	homodimer interface [polypeptide binding]; other site
228400003364	metal binding site [ion binding]; metal-binding site
228400003365	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
228400003366	homodimer interface [polypeptide binding]; other site
228400003367	active site
228400003368	putative chemical substrate binding site [chemical binding]; other site
228400003369	metal binding site [ion binding]; metal-binding site
228400003370	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
228400003371	H+ Antiporter protein; Region: 2A0121; TIGR00900
228400003372	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
228400003373	Ligand Binding Site [chemical binding]; other site
228400003374	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
228400003375	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
228400003376	motif 1; other site
228400003377	active site
228400003378	motif 2; other site
228400003379	motif 3; other site
228400003380	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
228400003381	DHHA1 domain; Region: DHHA1; pfam02272
228400003382	carbon storage regulator; Provisional; Region: PRK01712
228400003383	phosphomannomutase CpsG; Provisional; Region: PRK15414
228400003384	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
228400003385	active site
228400003386	substrate binding site [chemical binding]; other site
228400003387	metal binding site [ion binding]; metal-binding site
228400003388	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
228400003389	active site
228400003390	tetramer interface; other site
228400003391	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
228400003392	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
228400003393	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
228400003394	active site
228400003395	dimer interface [polypeptide binding]; other site
228400003396	metal binding site [ion binding]; metal-binding site
228400003397	shikimate kinase; Reviewed; Region: aroK; PRK00131
228400003398	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
228400003399	ADP binding site [chemical binding]; other site
228400003400	magnesium binding site [ion binding]; other site
228400003401	putative shikimate binding site; other site
228400003402	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
228400003403	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
228400003404	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
228400003405	Competence protein A; Region: Competence_A; pfam11104
228400003406	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
228400003407	Transglycosylase; Region: Transgly; pfam00912
228400003408	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
228400003409	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
228400003410	glutathione reductase; Validated; Region: PRK06116
228400003411	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
228400003412	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
228400003413	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
228400003414	bacterial Hfq-like; Region: Hfq; cd01716
228400003415	hexamer interface [polypeptide binding]; other site
228400003416	Sm1 motif; other site
228400003417	RNA binding site [nucleotide binding]; other site
228400003418	Sm2 motif; other site
228400003419	GTPase HflX; Provisional; Region: PRK11058
228400003420	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
228400003421	HflX GTPase family; Region: HflX; cd01878
228400003422	G1 box; other site
228400003423	GTP/Mg2+ binding site [chemical binding]; other site
228400003424	Switch I region; other site
228400003425	G2 box; other site
228400003426	G3 box; other site
228400003427	Switch II region; other site
228400003428	G4 box; other site
228400003429	G5 box; other site
228400003430	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
228400003431	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400003432	Walker A motif; other site
228400003433	ATP binding site [chemical binding]; other site
228400003434	Walker B motif; other site
228400003435	arginine finger; other site
228400003436	fumarate hydratase; Reviewed; Region: fumC; PRK00485
228400003437	Class II fumarases; Region: Fumarase_classII; cd01362
228400003438	active site
228400003439	tetramer interface [polypeptide binding]; other site
228400003440	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
228400003441	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400003442	non-specific DNA binding site [nucleotide binding]; other site
228400003443	salt bridge; other site
228400003444	sequence-specific DNA binding site [nucleotide binding]; other site
228400003445	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
228400003446	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
228400003447	prephenate dehydrogenase; Validated; Region: PRK08507
228400003448	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
228400003449	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
228400003450	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
228400003451	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
228400003452	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
228400003453	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400003454	motif II; other site
228400003455	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
228400003456	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
228400003457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
228400003458	NAD(P) binding site [chemical binding]; other site
228400003459	active site
228400003460	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
228400003461	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
228400003462	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
228400003463	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
228400003464	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
228400003465	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
228400003466	haemagglutination activity domain; Region: Haemagg_act; pfam05860
228400003467	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
228400003468	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
228400003469	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
228400003470	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
228400003471	proline aminopeptidase P II; Provisional; Region: PRK10879
228400003472	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
228400003473	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
228400003474	active site
228400003475	hypothetical protein; Reviewed; Region: PRK01736
228400003476	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
228400003477	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
228400003478	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
228400003479	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
228400003480	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
228400003481	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400003482	motif II; other site
228400003483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
228400003484	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
228400003485	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
228400003486	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
228400003487	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
228400003488	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
228400003489	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
228400003490	argininosuccinate lyase; Provisional; Region: PRK04833
228400003491	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
228400003492	active sites [active]
228400003493	tetramer interface [polypeptide binding]; other site
228400003494	hypothetical protein; Reviewed; Region: PRK01637
228400003495	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
228400003496	putative active site [active]
228400003497	dimerization interface [polypeptide binding]; other site
228400003498	putative tRNAtyr binding site [nucleotide binding]; other site
228400003499	N-acetylneuraminate lyase; Provisional; Region: PRK04147
228400003500	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
228400003501	inhibitor site; inhibition site
228400003502	active site
228400003503	dimer interface [polypeptide binding]; other site
228400003504	catalytic residue [active]
228400003505	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
228400003506	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
228400003507	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
228400003508	putative active site [active]
228400003509	Domain of unknown function (DUF386); Region: DUF386; pfam04074
228400003510	N-acetylmannosamine kinase; Provisional; Region: PRK05082
228400003511	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
228400003512	nucleotide binding site [chemical binding]; other site
228400003513	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
228400003514	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
228400003515	putative active site cavity [active]
228400003516	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
228400003517	active site
228400003518	catalytic triad [active]
228400003519	oxyanion hole [active]
228400003520	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
228400003521	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
228400003522	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
228400003523	DctM-like transporters; Region: DctM; pfam06808
228400003524	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
228400003525	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
228400003526	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
228400003527	RNase E interface [polypeptide binding]; other site
228400003528	trimer interface [polypeptide binding]; other site
228400003529	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
228400003530	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
228400003531	RNase E interface [polypeptide binding]; other site
228400003532	trimer interface [polypeptide binding]; other site
228400003533	active site
228400003534	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
228400003535	putative nucleic acid binding region [nucleotide binding]; other site
228400003536	G-X-X-G motif; other site
228400003537	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
228400003538	RNA binding site [nucleotide binding]; other site
228400003539	domain interface; other site
228400003540	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
228400003541	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
228400003542	ATP binding site [chemical binding]; other site
228400003543	Mg++ binding site [ion binding]; other site
228400003544	motif III; other site
228400003545	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400003546	nucleotide binding region [chemical binding]; other site
228400003547	ATP-binding site [chemical binding]; other site
228400003548	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
228400003549	putative RNA binding site [nucleotide binding]; other site
228400003550	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
228400003551	rRNA binding site [nucleotide binding]; other site
228400003552	predicted 30S ribosome binding site; other site
228400003553	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
228400003554	ligand binding site; other site
228400003555	tetramer interface; other site
228400003556	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
228400003557	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
228400003558	NAD binding site [chemical binding]; other site
228400003559	substrate binding site [chemical binding]; other site
228400003560	homodimer interface [polypeptide binding]; other site
228400003561	active site
228400003562	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
228400003563	L-lactate permease; Region: Lactate_perm; cl00701
228400003564	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
228400003565	Cysteine-rich domain; Region: CCG; pfam02754
228400003566	Cysteine-rich domain; Region: CCG; pfam02754
228400003567	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
228400003568	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
228400003569	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
228400003570	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
228400003571	Uncharacterized conserved protein [Function unknown]; Region: COG1556
228400003572	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
228400003573	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
228400003574	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
228400003575	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
228400003576	DsbD alpha interface [polypeptide binding]; other site
228400003577	catalytic residues [active]
228400003578	two-component response regulator; Provisional; Region: PRK11173
228400003579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
228400003580	active site
228400003581	phosphorylation site [posttranslational modification]
228400003582	intermolecular recognition site; other site
228400003583	dimerization interface [polypeptide binding]; other site
228400003584	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
228400003585	DNA binding site [nucleotide binding]
228400003586	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
228400003587	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
228400003588	RNA binding surface [nucleotide binding]; other site
228400003589	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
228400003590	active site
228400003591	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
228400003592	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
228400003593	homodimer interface [polypeptide binding]; other site
228400003594	oligonucleotide binding site [chemical binding]; other site
228400003595	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
228400003596	DNA polymerase I; Provisional; Region: PRK05755
228400003597	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
228400003598	active site
228400003599	metal binding site 1 [ion binding]; metal-binding site
228400003600	putative 5' ssDNA interaction site; other site
228400003601	metal binding site 3; metal-binding site
228400003602	metal binding site 2 [ion binding]; metal-binding site
228400003603	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
228400003604	putative DNA binding site [nucleotide binding]; other site
228400003605	putative metal binding site [ion binding]; other site
228400003606	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
228400003607	active site
228400003608	catalytic site [active]
228400003609	substrate binding site [chemical binding]; other site
228400003610	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
228400003611	active site
228400003612	DNA binding site [nucleotide binding]
228400003613	catalytic site [active]
228400003614	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
228400003615	Part of AAA domain; Region: AAA_19; pfam13245
228400003616	Family description; Region: UvrD_C_2; pfam13538
228400003617	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
228400003618	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
228400003619	active site
228400003620	DNA binding site [nucleotide binding]
228400003621	Int/Topo IB signature motif; other site
228400003622	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
228400003623	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
228400003624	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
228400003625	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400003626	non-specific DNA binding site [nucleotide binding]; other site
228400003627	Predicted transcriptional regulator [Transcription]; Region: COG2932
228400003628	salt bridge; other site
228400003629	sequence-specific DNA binding site [nucleotide binding]; other site
228400003630	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
228400003631	Catalytic site [active]
228400003632	tail protein; Provisional; Region: D; PHA02561
228400003633	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
228400003634	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
228400003635	Phage tail tube protein FII; Region: Phage_tube; pfam04985
228400003636	major tail sheath protein; Provisional; Region: FI; PHA02560
228400003637	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
228400003638	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
228400003639	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
228400003640	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
228400003641	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
228400003642	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400003643	non-specific DNA binding site [nucleotide binding]; other site
228400003644	salt bridge; other site
228400003645	sequence-specific DNA binding site [nucleotide binding]; other site
228400003646	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
228400003647	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
228400003648	Phage Tail Collar Domain; Region: Collar; pfam07484
228400003649	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
228400003650	baseplate assembly protein; Provisional; Region: J; PHA02568
228400003651	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
228400003652	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
228400003653	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
228400003654	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
228400003655	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
228400003656	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
228400003657	dimer interface [polypeptide binding]; other site
228400003658	phage virion morphogenesis (putative tail completion) protein; Region: tail_comp_S; TIGR01635
228400003659	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
228400003660	phosphodiesterase; Provisional; Region: PRK12704
228400003661	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
228400003662	catalytic residues [active]
228400003663	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
228400003664	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
228400003665	terminase endonuclease subunit; Provisional; Region: M; PHA02537
228400003666	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
228400003667	Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125
228400003668	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
228400003669	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
228400003670	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
228400003671	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
228400003672	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
228400003673	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
228400003674	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
228400003675	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
228400003676	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
228400003677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400003678	S-adenosylmethionine binding site [chemical binding]; other site
228400003679	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
228400003680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400003681	Walker A motif; other site
228400003682	ATP binding site [chemical binding]; other site
228400003683	Walker B motif; other site
228400003684	arginine finger; other site
228400003685	Peptidase family M41; Region: Peptidase_M41; pfam01434
228400003686	LicD family; Region: LicD; cl01378
228400003687	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
228400003688	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
228400003689	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
228400003690	generic binding surface II; other site
228400003691	generic binding surface I; other site
228400003692	Domain of unknown function DUF87; Region: DUF87; pfam01935
228400003693	AAA-like domain; Region: AAA_10; pfam12846
228400003694	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
228400003695	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
228400003696	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
228400003697	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
228400003698	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
228400003699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400003700	Walker A/P-loop; other site
228400003701	ATP binding site [chemical binding]; other site
228400003702	Q-loop/lid; other site
228400003703	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
228400003704	dihydropteroate synthase; Region: DHPS; TIGR01496
228400003705	substrate binding pocket [chemical binding]; other site
228400003706	dimer interface [polypeptide binding]; other site
228400003707	inhibitor binding site; inhibition site
228400003708	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
228400003709	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
228400003710	active site
228400003711	substrate binding site [chemical binding]; other site
228400003712	metal binding site [ion binding]; metal-binding site
228400003713	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
228400003714	catalytic core [active]
228400003715	Predicted permeases [General function prediction only]; Region: COG0679
228400003716	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
228400003717	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
228400003718	DEAD_2; Region: DEAD_2; pfam06733
228400003719	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
228400003720	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
228400003721	Glycoprotease family; Region: Peptidase_M22; pfam00814
228400003722	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
228400003723	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
228400003724	acyl-activating enzyme (AAE) consensus motif; other site
228400003725	putative AMP binding site [chemical binding]; other site
228400003726	putative active site [active]
228400003727	putative CoA binding site [chemical binding]; other site
228400003728	ribonuclease D; Provisional; Region: PRK10829
228400003729	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
228400003730	catalytic site [active]
228400003731	putative active site [active]
228400003732	putative substrate binding site [chemical binding]; other site
228400003733	HRDC domain; Region: HRDC; pfam00570
228400003734	outer membrane lipoprotein; Provisional; Region: PRK11023
228400003735	BON domain; Region: BON; pfam04972
228400003736	BON domain; Region: BON; pfam04972
228400003737	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
228400003738	dimer interface [polypeptide binding]; other site
228400003739	active site
228400003740	hypothetical protein; Reviewed; Region: PRK12497
228400003741	LppC putative lipoprotein; Region: LppC; pfam04348
228400003742	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
228400003743	putative ligand binding site [chemical binding]; other site
228400003744	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
228400003745	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
228400003746	putative SAM binding site [chemical binding]; other site
228400003747	putative homodimer interface [polypeptide binding]; other site
228400003748	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
228400003749	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
228400003750	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
228400003751	RNA binding surface [nucleotide binding]; other site
228400003752	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
228400003753	probable active site [active]
228400003754	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
228400003755	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400003756	trimer interface [polypeptide binding]; other site
228400003757	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003758	trimer interface [polypeptide binding]; other site
228400003759	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
228400003760	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
228400003761	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
228400003762	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
228400003763	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
228400003764	intersubunit interface [polypeptide binding]; other site
228400003765	active site
228400003766	catalytic residue [active]
228400003767	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
228400003768	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
228400003769	substrate binding site [chemical binding]; other site
228400003770	dimer interface [polypeptide binding]; other site
228400003771	ATP binding site [chemical binding]; other site
228400003772	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
228400003773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400003774	putative substrate translocation pore; other site
228400003775	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
228400003776	active site
228400003777	catalytic residues [active]
228400003778	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
228400003779	23S rRNA interface [nucleotide binding]; other site
228400003780	L3 interface [polypeptide binding]; other site
228400003781	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
228400003782	stringent starvation protein A; Provisional; Region: sspA; PRK09481
228400003783	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
228400003784	C-terminal domain interface [polypeptide binding]; other site
228400003785	putative GSH binding site (G-site) [chemical binding]; other site
228400003786	dimer interface [polypeptide binding]; other site
228400003787	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
228400003788	dimer interface [polypeptide binding]; other site
228400003789	N-terminal domain interface [polypeptide binding]; other site
228400003790	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
228400003791	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
228400003792	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
228400003793	putative dimer interface [polypeptide binding]; other site
228400003794	putative anticodon binding site; other site
228400003795	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
228400003796	homodimer interface [polypeptide binding]; other site
228400003797	motif 1; other site
228400003798	motif 2; other site
228400003799	active site
228400003800	motif 3; other site
228400003801	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
228400003802	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
228400003803	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
228400003804	Transcriptional regulator [Transcription]; Region: IclR; COG1414
228400003805	Bacterial transcriptional regulator; Region: IclR; pfam01614
228400003806	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
228400003807	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
228400003808	DctM-like transporters; Region: DctM; pfam06808
228400003809	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
228400003810	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
228400003811	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
228400003812	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
228400003813	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400003814	Walker A/P-loop; other site
228400003815	ATP binding site [chemical binding]; other site
228400003816	Q-loop/lid; other site
228400003817	ABC transporter signature motif; other site
228400003818	Walker B; other site
228400003819	D-loop; other site
228400003820	H-loop/switch region; other site
228400003821	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400003822	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400003823	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400003824	TM-ABC transporter signature motif; other site
228400003825	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315
228400003826	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
228400003827	putative ligand binding site [chemical binding]; other site
228400003828	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
228400003829	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
228400003830	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
228400003831	ligand binding site [chemical binding]; other site
228400003832	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
228400003833	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400003834	Walker A/P-loop; other site
228400003835	ATP binding site [chemical binding]; other site
228400003836	Q-loop/lid; other site
228400003837	ABC transporter signature motif; other site
228400003838	Walker B; other site
228400003839	D-loop; other site
228400003840	H-loop/switch region; other site
228400003841	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400003842	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400003843	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400003844	TM-ABC transporter signature motif; other site
228400003845	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
228400003846	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
228400003847	putative N- and C-terminal domain interface [polypeptide binding]; other site
228400003848	putative active site [active]
228400003849	MgATP binding site [chemical binding]; other site
228400003850	catalytic site [active]
228400003851	metal binding site [ion binding]; metal-binding site
228400003852	putative xylulose binding site [chemical binding]; other site
228400003853	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
228400003854	active site
228400003855	dimer interface [polypeptide binding]; other site
228400003856	magnesium binding site [ion binding]; other site
228400003857	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
228400003858	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
228400003859	AP (apurinic/apyrimidinic) site pocket; other site
228400003860	DNA interaction; other site
228400003861	Metal-binding active site; metal-binding site
228400003862	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
228400003863	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
228400003864	intersubunit interface [polypeptide binding]; other site
228400003865	active site
228400003866	Zn2+ binding site [ion binding]; other site
228400003867	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
228400003868	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400003869	active site
228400003870	motif I; other site
228400003871	motif II; other site
228400003872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400003873	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
228400003874	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
228400003875	chromosome condensation membrane protein; Provisional; Region: PRK14196
228400003876	putative hydrolase; Provisional; Region: PRK10976
228400003877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400003878	active site
228400003879	motif I; other site
228400003880	motif II; other site
228400003881	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
228400003882	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
228400003883	dimer interface [polypeptide binding]; other site
228400003884	FMN binding site [chemical binding]; other site
228400003885	Protein of unknown function (DUF406); Region: DUF406; pfam04175
228400003886	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
228400003887	aromatic amino acid transport protein; Region: araaP; TIGR00837
228400003888	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
228400003889	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
228400003890	Walker A/P-loop; other site
228400003891	ATP binding site [chemical binding]; other site
228400003892	Q-loop/lid; other site
228400003893	ABC transporter signature motif; other site
228400003894	Walker B; other site
228400003895	D-loop; other site
228400003896	H-loop/switch region; other site
228400003897	TOBE domain; Region: TOBE_2; pfam08402
228400003898	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
228400003899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400003900	dimer interface [polypeptide binding]; other site
228400003901	conserved gate region; other site
228400003902	putative PBP binding loops; other site
228400003903	ABC-ATPase subunit interface; other site
228400003904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400003905	dimer interface [polypeptide binding]; other site
228400003906	conserved gate region; other site
228400003907	putative PBP binding loops; other site
228400003908	ABC-ATPase subunit interface; other site
228400003909	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
228400003910	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
228400003911	D-lactate dehydrogenase; Provisional; Region: PRK11183
228400003912	FAD binding domain; Region: FAD_binding_4; pfam01565
228400003913	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
228400003914	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
228400003915	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
228400003916	trimer interface [polypeptide binding]; other site
228400003917	active site
228400003918	substrate binding site [chemical binding]; other site
228400003919	CoA binding site [chemical binding]; other site
228400003920	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
228400003921	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
228400003922	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
228400003923	putative active site [active]
228400003924	putative substrate binding site [chemical binding]; other site
228400003925	putative cosubstrate binding site; other site
228400003926	catalytic site [active]
228400003927	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
228400003928	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
228400003929	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
228400003930	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
228400003931	UDP-glucose 4-epimerase; Region: PLN02240
228400003932	NAD binding site [chemical binding]; other site
228400003933	homodimer interface [polypeptide binding]; other site
228400003934	active site
228400003935	substrate binding site [chemical binding]; other site
228400003936	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003937	trimer interface [polypeptide binding]; other site
228400003938	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400003939	trimer interface [polypeptide binding]; other site
228400003940	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003941	trimer interface [polypeptide binding]; other site
228400003942	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003943	trimer interface [polypeptide binding]; other site
228400003944	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400003945	trimer interface [polypeptide binding]; other site
228400003946	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400003947	trimer interface [polypeptide binding]; other site
228400003948	YadA-like C-terminal region; Region: YadA; pfam03895
228400003949	oligopeptidase A; Provisional; Region: PRK10911
228400003950	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
228400003951	active site
228400003952	Zn binding site [ion binding]; other site
228400003953	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
228400003954	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
228400003955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400003956	homodimer interface [polypeptide binding]; other site
228400003957	catalytic residue [active]
228400003958	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
228400003959	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
228400003960	putative dimerization interface [polypeptide binding]; other site
228400003961	Transcriptional regulators [Transcription]; Region: PurR; COG1609
228400003962	putative ligand binding site [chemical binding]; other site
228400003963	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
228400003964	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
228400003965	Protein of unknown function (DUF454); Region: DUF454; cl01063
228400003966	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
228400003967	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
228400003968	peptide binding site [polypeptide binding]; other site
228400003969	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
228400003970	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
228400003971	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
228400003972	active site
228400003973	FMN binding site [chemical binding]; other site
228400003974	substrate binding site [chemical binding]; other site
228400003975	catalytic residues [active]
228400003976	homodimer interface [polypeptide binding]; other site
228400003977	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
228400003978	aromatic amino acid transport protein; Region: araaP; TIGR00837
228400003979	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
228400003980	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
228400003981	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
228400003982	catalytic residue [active]
228400003983	phosphate acetyltransferase; Reviewed; Region: PRK05632
228400003984	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
228400003985	DRTGG domain; Region: DRTGG; pfam07085
228400003986	phosphate acetyltransferase; Region: pta; TIGR00651
228400003987	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
228400003988	propionate/acetate kinase; Provisional; Region: PRK12379
228400003989	hypothetical protein; Provisional; Region: PRK01816
228400003990	YcgL domain; Region: YcgL; pfam05166
228400003991	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
228400003992	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
228400003993	molybdopterin cofactor binding site [chemical binding]; other site
228400003994	substrate binding site [chemical binding]; other site
228400003995	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
228400003996	molybdopterin cofactor binding site; other site
228400003997	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
228400003998	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
228400003999	Methyltransferase domain; Region: Methyltransf_11; pfam08241
228400004000	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
228400004001	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
228400004002	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
228400004003	tRNA; other site
228400004004	putative tRNA binding site [nucleotide binding]; other site
228400004005	putative NADP binding site [chemical binding]; other site
228400004006	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
228400004007	multidrug efflux protein; Reviewed; Region: PRK01766
228400004008	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
228400004009	cation binding site [ion binding]; other site
228400004010	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
228400004011	Lumazine binding domain; Region: Lum_binding; pfam00677
228400004012	Lumazine binding domain; Region: Lum_binding; pfam00677
228400004013	recombination factor protein RarA; Reviewed; Region: PRK13342
228400004014	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400004015	Walker A motif; other site
228400004016	ATP binding site [chemical binding]; other site
228400004017	Walker B motif; other site
228400004018	arginine finger; other site
228400004019	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
228400004020	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
228400004021	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
228400004022	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
228400004023	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
228400004024	serine endoprotease; Provisional; Region: PRK10942
228400004025	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
228400004026	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
228400004027	protein binding site [polypeptide binding]; other site
228400004028	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
228400004029	Low molecular weight phosphatase family; Region: LMWPc; cd00115
228400004030	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
228400004031	active site
228400004032	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
228400004033	ribosome maturation protein RimP; Reviewed; Region: PRK00092
228400004034	hypothetical protein; Provisional; Region: PRK14641
228400004035	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
228400004036	putative oligomer interface [polypeptide binding]; other site
228400004037	putative RNA binding site [nucleotide binding]; other site
228400004038	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
228400004039	NusA N-terminal domain; Region: NusA_N; pfam08529
228400004040	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
228400004041	RNA binding site [nucleotide binding]; other site
228400004042	homodimer interface [polypeptide binding]; other site
228400004043	NusA-like KH domain; Region: KH_5; pfam13184
228400004044	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
228400004045	G-X-X-G motif; other site
228400004046	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
228400004047	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
228400004048	translation initiation factor IF-2; Region: IF-2; TIGR00487
228400004049	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
228400004050	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
228400004051	G1 box; other site
228400004052	putative GEF interaction site [polypeptide binding]; other site
228400004053	GTP/Mg2+ binding site [chemical binding]; other site
228400004054	Switch I region; other site
228400004055	G2 box; other site
228400004056	G3 box; other site
228400004057	Switch II region; other site
228400004058	G4 box; other site
228400004059	G5 box; other site
228400004060	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
228400004061	Translation-initiation factor 2; Region: IF-2; pfam11987
228400004062	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
228400004063	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
228400004064	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
228400004065	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
228400004066	RNA binding site [nucleotide binding]; other site
228400004067	active site
228400004068	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
228400004069	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
228400004070	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
228400004071	THF binding site; other site
228400004072	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
228400004073	substrate binding site [chemical binding]; other site
228400004074	THF binding site; other site
228400004075	zinc-binding site [ion binding]; other site
228400004076	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
228400004077	Transglycosylase; Region: Transgly; pfam00912
228400004078	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
228400004079	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
228400004080	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
228400004081	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
228400004082	active site
228400004083	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
228400004084	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
228400004085	metal binding triad; other site
228400004086	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
228400004087	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
228400004088	Zn2+ binding site [ion binding]; other site
228400004089	Mg2+ binding site [ion binding]; other site
228400004090	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
228400004091	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
228400004092	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
228400004093	homopentamer interface [polypeptide binding]; other site
228400004094	active site
228400004095	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
228400004096	putative RNA binding site [nucleotide binding]; other site
228400004097	thiamine monophosphate kinase; Provisional; Region: PRK05731
228400004098	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
228400004099	ATP binding site [chemical binding]; other site
228400004100	dimerization interface [polypeptide binding]; other site
228400004101	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
228400004102	tetramer interfaces [polypeptide binding]; other site
228400004103	binuclear metal-binding site [ion binding]; other site
228400004104	LysE type translocator; Region: LysE; cl00565
228400004105	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
228400004106	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
228400004107	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
228400004108	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
228400004109	putative catalytic site [active]
228400004110	putative phosphate binding site [ion binding]; other site
228400004111	active site
228400004112	metal binding site A [ion binding]; metal-binding site
228400004113	DNA binding site [nucleotide binding]
228400004114	putative AP binding site [nucleotide binding]; other site
228400004115	putative metal binding site B [ion binding]; other site
228400004116	Family of unknown function (DUF695); Region: DUF695; pfam05117
228400004117	TIGR01619 family protein; Region: hyp_HI0040
228400004118	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
228400004119	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
228400004120	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400004121	homodimer interface [polypeptide binding]; other site
228400004122	catalytic residue [active]
228400004123	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
228400004124	ATP-grasp domain; Region: ATP-grasp; pfam02222
228400004125	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
228400004126	active site clefts [active]
228400004127	zinc binding site [ion binding]; other site
228400004128	dimer interface [polypeptide binding]; other site
228400004129	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
228400004130	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
228400004131	substrate binding site [chemical binding]; other site
228400004132	active site
228400004133	catalytic residues [active]
228400004134	heterodimer interface [polypeptide binding]; other site
228400004135	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
228400004136	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
228400004137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400004138	catalytic residue [active]
228400004139	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
228400004140	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
228400004141	active site
228400004142	ribulose/triose binding site [chemical binding]; other site
228400004143	phosphate binding site [ion binding]; other site
228400004144	substrate (anthranilate) binding pocket [chemical binding]; other site
228400004145	product (indole) binding pocket [chemical binding]; other site
228400004146	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
228400004147	active site
228400004148	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
228400004149	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
228400004150	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
228400004151	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
228400004152	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
228400004153	glutamine binding [chemical binding]; other site
228400004154	catalytic triad [active]
228400004155	anthranilate synthase component I; Provisional; Region: PRK13564
228400004156	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
228400004157	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
228400004158	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
228400004159	putative inner membrane peptidase; Provisional; Region: PRK11778
228400004160	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
228400004161	tandem repeat interface [polypeptide binding]; other site
228400004162	oligomer interface [polypeptide binding]; other site
228400004163	active site residues [active]
228400004164	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
228400004165	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
228400004166	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
228400004167	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
228400004168	ligand binding site [chemical binding]; other site
228400004169	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
228400004170	Phosphotransferase enzyme family; Region: APH; pfam01636
228400004171	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
228400004172	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
228400004173	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
228400004174	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
228400004175	active site
228400004176	dimer interface [polypeptide binding]; other site
228400004177	motif 1; other site
228400004178	motif 2; other site
228400004179	motif 3; other site
228400004180	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
228400004181	anticodon binding site; other site
228400004182	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
228400004183	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
228400004184	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
228400004185	Protein of unknown function, DUF462; Region: DUF462; cl01190
228400004186	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
228400004187	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
228400004188	Walker A/P-loop; other site
228400004189	ATP binding site [chemical binding]; other site
228400004190	Q-loop/lid; other site
228400004191	ABC transporter signature motif; other site
228400004192	Walker B; other site
228400004193	D-loop; other site
228400004194	H-loop/switch region; other site
228400004195	inner membrane transport permease; Provisional; Region: PRK15066
228400004196	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
228400004197	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
228400004198	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
228400004199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
228400004200	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
228400004201	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
228400004202	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
228400004203	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
228400004204	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
228400004205	tRNA pseudouridine synthase C; Provisional; Region: PRK11112
228400004206	active site
228400004207	Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701
228400004208	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
228400004209	DNA-binding site [nucleotide binding]; DNA binding site
228400004210	RNA-binding motif; other site
228400004211	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
228400004212	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
228400004213	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
228400004214	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
228400004215	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
228400004216	dimer interface [polypeptide binding]; other site
228400004217	motif 1; other site
228400004218	active site
228400004219	motif 2; other site
228400004220	motif 3; other site
228400004221	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
228400004222	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
228400004223	putative tRNA-binding site [nucleotide binding]; other site
228400004224	B3/4 domain; Region: B3_4; pfam03483
228400004225	tRNA synthetase B5 domain; Region: B5; smart00874
228400004226	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
228400004227	dimer interface [polypeptide binding]; other site
228400004228	motif 1; other site
228400004229	motif 3; other site
228400004230	motif 2; other site
228400004231	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
228400004232	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
228400004233	IHF dimer interface [polypeptide binding]; other site
228400004234	IHF - DNA interface [nucleotide binding]; other site
228400004235	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
228400004236	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
228400004237	Ligand Binding Site [chemical binding]; other site
228400004238	condesin subunit F; Provisional; Region: PRK05260
228400004239	condesin subunit E; Provisional; Region: PRK05256
228400004240	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
228400004241	P-loop containing region of AAA domain; Region: AAA_29; cl17516
228400004242	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
228400004243	HsdM N-terminal domain; Region: HsdM_N; pfam12161
228400004244	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
228400004245	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
228400004246	exonuclease I; Provisional; Region: sbcB; PRK11779
228400004247	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
228400004248	active site
228400004249	catalytic site [active]
228400004250	substrate binding site [chemical binding]; other site
228400004251	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
228400004252	LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235
228400004253	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
228400004254	5S rRNA interface [nucleotide binding]; other site
228400004255	CTC domain interface [polypeptide binding]; other site
228400004256	L16 interface [polypeptide binding]; other site
228400004257	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
228400004258	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
228400004259	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
228400004260	23S rRNA binding site [nucleotide binding]; other site
228400004261	L21 binding site [polypeptide binding]; other site
228400004262	L13 binding site [polypeptide binding]; other site
228400004263	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
228400004264	translation initiation factor IF-3; Region: infC; TIGR00168
228400004265	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
228400004266	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
228400004267	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
228400004268	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
228400004269	ligand binding site [chemical binding]; other site
228400004270	flexible hinge region; other site
228400004271	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
228400004272	putative switch regulator; other site
228400004273	non-specific DNA interactions [nucleotide binding]; other site
228400004274	DNA binding site [nucleotide binding]
228400004275	sequence specific DNA binding site [nucleotide binding]; other site
228400004276	putative cAMP binding site [chemical binding]; other site
228400004277	universal stress protein UspE; Provisional; Region: PRK11175
228400004278	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
228400004279	Ligand Binding Site [chemical binding]; other site
228400004280	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
228400004281	Ligand Binding Site [chemical binding]; other site
228400004282	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
228400004283	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
228400004284	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
228400004285	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
228400004286	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
228400004287	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
228400004288	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
228400004289	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
228400004290	active site
228400004291	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
228400004292	aminopeptidase N; Provisional; Region: pepN; PRK14015
228400004293	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
228400004294	active site
228400004295	Zn binding site [ion binding]; other site
228400004296	glycogen phosphorylase; Provisional; Region: PRK14986
228400004297	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
228400004298	homodimer interface [polypeptide binding]; other site
228400004299	active site pocket [active]
228400004300	glycogen synthase; Provisional; Region: glgA; PRK00654
228400004301	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
228400004302	ADP-binding pocket [chemical binding]; other site
228400004303	homodimer interface [polypeptide binding]; other site
228400004304	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
228400004305	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
228400004306	ligand binding site; other site
228400004307	oligomer interface; other site
228400004308	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
228400004309	N-terminal domain interface [polypeptide binding]; other site
228400004310	sulfate 1 binding site; other site
228400004311	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
228400004312	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
228400004313	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
228400004314	active site
228400004315	catalytic site [active]
228400004316	glycogen branching enzyme; Provisional; Region: PRK05402
228400004317	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
228400004318	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
228400004319	active site
228400004320	catalytic site [active]
228400004321	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
228400004322	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
228400004323	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
228400004324	hypothetical protein; Provisional; Region: PRK05170
228400004325	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
228400004326	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
228400004327	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
228400004328	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
228400004329	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
228400004330	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
228400004331	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
228400004332	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
228400004333	active site
228400004334	HIGH motif; other site
228400004335	nucleotide binding site [chemical binding]; other site
228400004336	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
228400004337	KMSKS motif; other site
228400004338	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
228400004339	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
228400004340	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
228400004341	phosphate binding site [ion binding]; other site
228400004342	putative substrate binding pocket [chemical binding]; other site
228400004343	dimer interface [polypeptide binding]; other site
228400004344	tetrathionate reductase subunit A; Provisional; Region: PRK14991
228400004345	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
228400004346	molybdopterin cofactor binding site; other site
228400004347	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
228400004348	putative molybdopterin cofactor binding site [chemical binding]; other site
228400004349	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
228400004350	putative molybdopterin cofactor binding site; other site
228400004351	tetrathionate reductase subunit C; Provisional; Region: PRK14992
228400004352	tetrathionate reductase subunit B; Provisional; Region: PRK14993
228400004353	4Fe-4S binding domain; Region: Fer4; pfam00037
228400004354	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
228400004355	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
228400004356	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
228400004357	dimer interface [polypeptide binding]; other site
228400004358	phosphorylation site [posttranslational modification]
228400004359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
228400004360	ATP binding site [chemical binding]; other site
228400004361	Mg2+ binding site [ion binding]; other site
228400004362	G-X-G motif; other site
228400004363	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
228400004364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
228400004365	active site
228400004366	phosphorylation site [posttranslational modification]
228400004367	intermolecular recognition site; other site
228400004368	dimerization interface [polypeptide binding]; other site
228400004369	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
228400004370	DNA binding residues [nucleotide binding]
228400004371	dimerization interface [polypeptide binding]; other site
228400004372	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
228400004373	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
228400004374	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
228400004375	Ligand Binding Site [chemical binding]; other site
228400004376	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
228400004377	active site residue [active]
228400004378	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
228400004379	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
228400004380	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
228400004381	substrate binding pocket [chemical binding]; other site
228400004382	chain length determination region; other site
228400004383	substrate-Mg2+ binding site; other site
228400004384	catalytic residues [active]
228400004385	aspartate-rich region 1; other site
228400004386	active site lid residues [active]
228400004387	aspartate-rich region 2; other site
228400004388	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
228400004389	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
228400004390	TPP-binding site; other site
228400004391	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
228400004392	PYR/PP interface [polypeptide binding]; other site
228400004393	dimer interface [polypeptide binding]; other site
228400004394	TPP binding site [chemical binding]; other site
228400004395	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
228400004396	Predicted membrane protein [Function unknown]; Region: COG2431
228400004397	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
228400004398	active site 2 [active]
228400004399	dimer interface [polypeptide binding]; other site
228400004400	active site 1 [active]
228400004401	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
228400004402	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
228400004403	tandem repeat interface [polypeptide binding]; other site
228400004404	oligomer interface [polypeptide binding]; other site
228400004405	active site residues [active]
228400004406	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
228400004407	tandem repeat interface [polypeptide binding]; other site
228400004408	oligomer interface [polypeptide binding]; other site
228400004409	active site residues [active]
228400004410	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
228400004411	putative FMN binding site [chemical binding]; other site
228400004412	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
228400004413	homodecamer interface [polypeptide binding]; other site
228400004414	GTP cyclohydrolase I; Provisional; Region: PLN03044
228400004415	active site
228400004416	putative catalytic site residues [active]
228400004417	zinc binding site [ion binding]; other site
228400004418	GTP-CH-I/GFRP interaction surface; other site
228400004419	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
228400004420	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
228400004421	dimer interface [polypeptide binding]; other site
228400004422	putative functional site; other site
228400004423	putative MPT binding site; other site
228400004424	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
228400004425	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
228400004426	ATP binding site [chemical binding]; other site
228400004427	substrate interface [chemical binding]; other site
228400004428	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
228400004429	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
228400004430	active site
228400004431	substrate binding site [chemical binding]; other site
228400004432	cosubstrate binding site; other site
228400004433	catalytic site [active]
228400004434	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
228400004435	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
228400004436	active site
228400004437	interdomain interaction site; other site
228400004438	putative metal-binding site [ion binding]; other site
228400004439	nucleotide binding site [chemical binding]; other site
228400004440	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
228400004441	domain I; other site
228400004442	DNA binding groove [nucleotide binding]
228400004443	phosphate binding site [ion binding]; other site
228400004444	domain II; other site
228400004445	domain III; other site
228400004446	nucleotide binding site [chemical binding]; other site
228400004447	catalytic site [active]
228400004448	domain IV; other site
228400004449	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
228400004450	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
228400004451	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
228400004452	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
228400004453	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
228400004454	Flavoprotein; Region: Flavoprotein; pfam02441
228400004455	amidophosphoribosyltransferase; Provisional; Region: PRK09246
228400004456	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
228400004457	active site
228400004458	tetramer interface [polypeptide binding]; other site
228400004459	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
228400004460	active site
228400004461	Colicin V production protein; Region: Colicin_V; cl00567
228400004462	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
228400004463	KpsF/GutQ family protein; Region: kpsF; TIGR00393
228400004464	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
228400004465	putative active site [active]
228400004466	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
228400004467	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
228400004468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400004469	active site
228400004470	motif I; other site
228400004471	motif II; other site
228400004472	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
228400004473	Ferritin-like domain; Region: Ferritin; pfam00210
228400004474	ferroxidase diiron center [ion binding]; other site
228400004475	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
228400004476	Ferritin-like domain; Region: Ferritin; pfam00210
228400004477	ferroxidase diiron center [ion binding]; other site
228400004478	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
228400004479	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
228400004480	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
228400004481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
228400004482	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
228400004483	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
228400004484	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
228400004485	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
228400004486	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
228400004487	inhibitor-cofactor binding pocket; inhibition site
228400004488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400004489	catalytic residue [active]
228400004490	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
228400004491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400004492	catalytic residue [active]
228400004493	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
228400004494	AAA domain; Region: AAA_30; pfam13604
228400004495	Family description; Region: UvrD_C_2; pfam13538
228400004496	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
228400004497	Part of AAA domain; Region: AAA_19; pfam13245
228400004498	Family description; Region: UvrD_C_2; pfam13538
228400004499	heat shock protein HtpX; Provisional; Region: PRK05457
228400004500	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
228400004501	active site
228400004502	DNA polymerase IV; Validated; Region: PRK02406
228400004503	DNA binding site [nucleotide binding]
228400004504	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
228400004505	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
228400004506	pyridoxamine kinase; Validated; Region: PRK05756
228400004507	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
228400004508	dimer interface [polypeptide binding]; other site
228400004509	pyridoxal binding site [chemical binding]; other site
228400004510	ATP binding site [chemical binding]; other site
228400004511	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
228400004512	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
228400004513	Ligand Binding Site [chemical binding]; other site
228400004514	TilS substrate binding domain; Region: TilS; pfam09179
228400004515	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
228400004516	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
228400004517	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
228400004518	active site
228400004519	dimer interface [polypeptide binding]; other site
228400004520	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
228400004521	dimer interface [polypeptide binding]; other site
228400004522	active site
228400004523	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
228400004524	alanine racemase; Reviewed; Region: alr; PRK00053
228400004525	active site
228400004526	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
228400004527	substrate binding site [chemical binding]; other site
228400004528	catalytic residues [active]
228400004529	dimer interface [polypeptide binding]; other site
228400004530	replicative DNA helicase; Validated; Region: PRK06904
228400004531	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
228400004532	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
228400004533	Walker A motif; other site
228400004534	ATP binding site [chemical binding]; other site
228400004535	Walker B motif; other site
228400004536	DNA binding loops [nucleotide binding]
228400004537	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
228400004538	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
228400004539	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
228400004540	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
228400004541	FtsX-like permease family; Region: FtsX; pfam02687
228400004542	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
228400004543	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
228400004544	Walker A/P-loop; other site
228400004545	ATP binding site [chemical binding]; other site
228400004546	Q-loop/lid; other site
228400004547	ABC transporter signature motif; other site
228400004548	Walker B; other site
228400004549	D-loop; other site
228400004550	H-loop/switch region; other site
228400004551	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
228400004552	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
228400004553	FtsX-like permease family; Region: FtsX; pfam02687
228400004554	glycerate dehydrogenase; Provisional; Region: PRK06932
228400004555	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
228400004556	putative ligand binding site [chemical binding]; other site
228400004557	putative NAD binding site [chemical binding]; other site
228400004558	catalytic site [active]
228400004559	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
228400004560	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
228400004561	Uncharacterized conserved protein [Function unknown]; Region: COG2912
228400004562	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
228400004563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
228400004564	TPR motif; other site
228400004565	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
228400004566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400004567	RDD family; Region: RDD; pfam06271
228400004568	peptide chain release factor 1; Validated; Region: prfA; PRK00591
228400004569	This domain is found in peptide chain release factors; Region: PCRF; smart00937
228400004570	RF-1 domain; Region: RF-1; pfam00472
228400004571	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
228400004572	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
228400004573	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
228400004574	putative metal binding site [ion binding]; other site
228400004575	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
228400004576	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
228400004577	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
228400004578	active site
228400004579	HIGH motif; other site
228400004580	KMSK motif region; other site
228400004581	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
228400004582	tRNA binding surface [nucleotide binding]; other site
228400004583	anticodon binding site; other site
228400004584	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
228400004585	CoA binding domain; Region: CoA_binding; smart00881
228400004586	CoA-ligase; Region: Ligase_CoA; pfam00549
228400004587	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
228400004588	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
228400004589	CoA-ligase; Region: Ligase_CoA; pfam00549
228400004590	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
228400004591	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
228400004592	E3 interaction surface; other site
228400004593	lipoyl attachment site [posttranslational modification]; other site
228400004594	e3 binding domain; Region: E3_binding; pfam02817
228400004595	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
228400004596	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
228400004597	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
228400004598	TPP-binding site [chemical binding]; other site
228400004599	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
228400004600	PYR/PP interface [polypeptide binding]; other site
228400004601	dimer interface [polypeptide binding]; other site
228400004602	TPP binding site [chemical binding]; other site
228400004603	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
228400004604	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
228400004605	dimer interface [polypeptide binding]; other site
228400004606	active site
228400004607	citrylCoA binding site [chemical binding]; other site
228400004608	NADH binding [chemical binding]; other site
228400004609	cationic pore residues; other site
228400004610	oxalacetate/citrate binding site [chemical binding]; other site
228400004611	coenzyme A binding site [chemical binding]; other site
228400004612	catalytic triad [active]
228400004613	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
228400004614	dimer interface [polypeptide binding]; other site
228400004615	putative radical transfer pathway; other site
228400004616	diiron center [ion binding]; other site
228400004617	tyrosyl radical; other site
228400004618	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
228400004619	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
228400004620	catalytic loop [active]
228400004621	iron binding site [ion binding]; other site
228400004622	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
228400004623	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
228400004624	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
228400004625	Zn2+ binding site [ion binding]; other site
228400004626	Mg2+ binding site [ion binding]; other site
228400004627	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
228400004628	Staphylococcal nuclease homologues; Region: SNc; smart00318
228400004629	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
228400004630	Catalytic site; other site
228400004631	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
228400004632	Aminotransferase class-V; Region: Aminotran_5; pfam00266
228400004633	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
228400004634	catalytic residue [active]
228400004635	Fe-S metabolism associated domain; Region: SufE; cl00951
228400004636	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
228400004637	FIC domain binding interface [polypeptide binding]; other site
228400004638	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
228400004639	Fic/DOC family; Region: Fic; cl00960
228400004640	RelB antitoxin; Region: RelB; cl01171
228400004641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
228400004642	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
228400004643	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
228400004644	trimer interface [polypeptide binding]; other site
228400004645	eyelet of channel; other site
228400004646	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
228400004647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
228400004648	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
228400004649	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
228400004650	tetratricopeptide repeat protein; Provisional; Region: PRK11788
228400004651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
228400004652	binding surface
228400004653	TPR motif; other site
228400004654	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
228400004655	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
228400004656	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
228400004657	IHF dimer interface [polypeptide binding]; other site
228400004658	IHF - DNA interface [nucleotide binding]; other site
228400004659	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
228400004660	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
228400004661	RNA binding site [nucleotide binding]; other site
228400004662	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
228400004663	RNA binding site [nucleotide binding]; other site
228400004664	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
228400004665	RNA binding site [nucleotide binding]; other site
228400004666	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
228400004667	RNA binding site [nucleotide binding]; other site
228400004668	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
228400004669	RNA binding site [nucleotide binding]; other site
228400004670	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
228400004671	RNA binding site [nucleotide binding]; other site
228400004672	cytidylate kinase; Provisional; Region: cmk; PRK00023
228400004673	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
228400004674	CMP-binding site; other site
228400004675	The sites determining sugar specificity; other site
228400004676	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
228400004677	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
228400004678	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
228400004679	trimer interface [polypeptide binding]; other site
228400004680	active site
228400004681	UDP-GlcNAc binding site [chemical binding]; other site
228400004682	lipid binding site [chemical binding]; lipid-binding site
228400004683	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
228400004684	periplasmic chaperone; Provisional; Region: PRK10780
228400004685	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
228400004686	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
228400004687	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
228400004688	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
228400004689	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
228400004690	Surface antigen; Region: Bac_surface_Ag; pfam01103
228400004691	zinc metallopeptidase RseP; Provisional; Region: PRK10779
228400004692	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
228400004693	active site
228400004694	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
228400004695	protein binding site [polypeptide binding]; other site
228400004696	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
228400004697	protein binding site [polypeptide binding]; other site
228400004698	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
228400004699	putative substrate binding region [chemical binding]; other site
228400004700	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
228400004701	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
228400004702	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
228400004703	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
228400004704	catalytic residue [active]
228400004705	putative FPP diphosphate  binding site; other site
228400004706	putative FPP binding hydrophobic cleft; other site
228400004707	dimer interface [polypeptide binding]; other site
228400004708	putative IPP diphosphate binding site; other site
228400004709	Uncharacterized integral membrane protein [Function unknown]; Region: COG5413
228400004710	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
228400004711	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
228400004712	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
228400004713	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
228400004714	ribosome recycling factor; Reviewed; Region: frr; PRK00083
228400004715	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
228400004716	hinge region; other site
228400004717	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
228400004718	putative nucleotide binding site [chemical binding]; other site
228400004719	uridine monophosphate binding site [chemical binding]; other site
228400004720	homohexameric interface [polypeptide binding]; other site
228400004721	Protein of unknown function (DUF721); Region: DUF721; cl02324
228400004722	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
228400004723	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
228400004724	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
228400004725	SEC-C motif; Region: SEC-C; pfam02810
228400004726	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
228400004727	active site
228400004728	8-oxo-dGMP binding site [chemical binding]; other site
228400004729	nudix motif; other site
228400004730	metal binding site [ion binding]; metal-binding site
228400004731	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
228400004732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400004733	ATP binding site [chemical binding]; other site
228400004734	putative Mg++ binding site [ion binding]; other site
228400004735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400004736	nucleotide binding region [chemical binding]; other site
228400004737	ATP-binding site [chemical binding]; other site
228400004738	Helicase associated domain (HA2); Region: HA2; pfam04408
228400004739	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
228400004740	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
228400004741	Predicted membrane protein [Function unknown]; Region: COG2707
228400004742	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
228400004743	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
228400004744	dsDNA-mimic protein; Reviewed; Region: PRK05094
228400004745	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
228400004746	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
228400004747	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
228400004748	active site
228400004749	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
228400004750	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
228400004751	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
228400004752	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
228400004753	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
228400004754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
228400004755	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
228400004756	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
228400004757	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
228400004758	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
228400004759	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
228400004760	ArsC family; Region: ArsC; pfam03960
228400004761	catalytic residues [active]
228400004762	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
228400004763	Domain of unknown function DUF20; Region: UPF0118; pfam01594
228400004764	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
228400004765	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
228400004766	substrate binding pocket [chemical binding]; other site
228400004767	membrane-bound complex binding site; other site
228400004768	hinge residues; other site
228400004769	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
228400004770	N-acetyl-D-glucosamine binding site [chemical binding]; other site
228400004771	catalytic residue [active]
228400004772	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400004773	trimer interface [polypeptide binding]; other site
228400004774	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400004775	trimer interface [polypeptide binding]; other site
228400004776	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400004777	trimer interface [polypeptide binding]; other site
228400004778	YadA-like C-terminal region; Region: YadA; pfam03895
228400004779	biotin synthase; Region: bioB; TIGR00433
228400004780	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400004781	FeS/SAM binding site; other site
228400004782	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
228400004783	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
228400004784	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
228400004785	Walker A/P-loop; other site
228400004786	ATP binding site [chemical binding]; other site
228400004787	Q-loop/lid; other site
228400004788	ABC transporter signature motif; other site
228400004789	Walker B; other site
228400004790	D-loop; other site
228400004791	H-loop/switch region; other site
228400004792	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
228400004793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400004794	dimer interface [polypeptide binding]; other site
228400004795	conserved gate region; other site
228400004796	putative PBP binding loops; other site
228400004797	ABC-ATPase subunit interface; other site
228400004798	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
228400004799	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
228400004800	haemagglutination activity domain; Region: Haemagg_act; pfam05860
228400004801	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
228400004802	Fic/DOC family; Region: Fic; pfam02661
228400004803	Fic family protein [Function unknown]; Region: COG3177
228400004804	Fic/DOC family; Region: Fic; pfam02661
228400004805	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543
228400004806	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
228400004807	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
228400004808	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
228400004809	Predicted permease [General function prediction only]; Region: COG2056
228400004810	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
228400004811	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
228400004812	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
228400004813	RNA polymerase sigma factor; Provisional; Region: PRK12530
228400004814	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
228400004815	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
228400004816	DNA binding residues [nucleotide binding]
228400004817	TMAO/DMSO reductase; Reviewed; Region: PRK05363
228400004818	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
228400004819	Moco binding site; other site
228400004820	metal coordination site [ion binding]; other site
228400004821	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
228400004822	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
228400004823	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
228400004824	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
228400004825	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
228400004826	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
228400004827	putative RNA binding site [nucleotide binding]; other site
228400004828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400004829	S-adenosylmethionine binding site [chemical binding]; other site
228400004830	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
228400004831	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
228400004832	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
228400004833	Walker A/P-loop; other site
228400004834	ATP binding site [chemical binding]; other site
228400004835	Q-loop/lid; other site
228400004836	ABC transporter signature motif; other site
228400004837	Walker B; other site
228400004838	D-loop; other site
228400004839	H-loop/switch region; other site
228400004840	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
228400004841	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
228400004842	Competence protein; Region: Competence; pfam03772
228400004843	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
228400004844	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
228400004845	poly(A) polymerase; Region: pcnB; TIGR01942
228400004846	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
228400004847	active site
228400004848	NTP binding site [chemical binding]; other site
228400004849	metal binding triad [ion binding]; metal-binding site
228400004850	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
228400004851	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
228400004852	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
228400004853	catalytic center binding site [active]
228400004854	ATP binding site [chemical binding]; other site
228400004855	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
228400004856	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
228400004857	active site
228400004858	dimer interface [polypeptide binding]; other site
228400004859	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
228400004860	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
228400004861	active site
228400004862	trimer interface [polypeptide binding]; other site
228400004863	allosteric site; other site
228400004864	active site lid [active]
228400004865	hexamer (dimer of trimers) interface [polypeptide binding]; other site
228400004866	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
228400004867	MoaE homodimer interface [polypeptide binding]; other site
228400004868	MoaD interaction [polypeptide binding]; other site
228400004869	active site residues [active]
228400004870	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
228400004871	MoaE interaction surface [polypeptide binding]; other site
228400004872	MoeB interaction surface [polypeptide binding]; other site
228400004873	thiocarboxylated glycine; other site
228400004874	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
228400004875	trimer interface [polypeptide binding]; other site
228400004876	dimer interface [polypeptide binding]; other site
228400004877	putative active site [active]
228400004878	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
228400004879	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400004880	FeS/SAM binding site; other site
228400004881	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
228400004882	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
228400004883	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
228400004884	DNA binding site [nucleotide binding]
228400004885	domain linker motif; other site
228400004886	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
228400004887	dimerization interface [polypeptide binding]; other site
228400004888	ligand binding site [chemical binding]; other site
228400004889	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
228400004890	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
228400004891	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
228400004892	substrate binding site [chemical binding]; other site
228400004893	dimerization interface [polypeptide binding]; other site
228400004894	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
228400004895	putative GSH binding site [chemical binding]; other site
228400004896	catalytic residues [active]
228400004897	outer membrane protein A; Reviewed; Region: PRK10808
228400004898	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
228400004899	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
228400004900	ligand binding site [chemical binding]; other site
228400004901	putative peptidase; Provisional; Region: PRK11649
228400004902	Peptidase family M23; Region: Peptidase_M23; pfam01551
228400004903	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
228400004904	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
228400004905	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
228400004906	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
228400004907	ABC-ATPase subunit  interface; other site
228400004908	dimer interface [polypeptide binding]; other site
228400004909	putative PBP binding regions; other site
228400004910	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
228400004911	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
228400004912	fructokinase; Reviewed; Region: PRK09557
228400004913	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
228400004914	nucleotide binding site [chemical binding]; other site
228400004915	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
228400004916	active site
228400004917	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
228400004918	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
228400004919	dimerization interface [polypeptide binding]; other site
228400004920	active site
228400004921	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
228400004922	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
228400004923	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
228400004924	FAD binding domain; Region: FAD_binding_4; pfam01565
228400004925	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
228400004926	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
228400004927	CoenzymeA binding site [chemical binding]; other site
228400004928	subunit interaction site [polypeptide binding]; other site
228400004929	PHB binding site; other site
228400004930	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
228400004931	ferrochelatase; Reviewed; Region: hemH; PRK00035
228400004932	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
228400004933	C-terminal domain interface [polypeptide binding]; other site
228400004934	active site
228400004935	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
228400004936	active site
228400004937	N-terminal domain interface [polypeptide binding]; other site
228400004938	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
228400004939	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
228400004940	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
228400004941	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
228400004942	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
228400004943	protein binding site [polypeptide binding]; other site
228400004944	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
228400004945	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
228400004946	catalytic motif [active]
228400004947	Zn binding site [ion binding]; other site
228400004948	RibD C-terminal domain; Region: RibD_C; cl17279
228400004949	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
228400004950	ATP cone domain; Region: ATP-cone; pfam03477
228400004951	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
228400004952	AzlC protein; Region: AzlC; cl00570
228400004953	Transcriptional regulator [Transcription]; Region: LysR; COG0583
228400004954	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
228400004955	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
228400004956	putative dimerization interface [polypeptide binding]; other site
228400004957	malate dehydrogenase; Provisional; Region: PRK05086
228400004958	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
228400004959	NAD binding site [chemical binding]; other site
228400004960	dimerization interface [polypeptide binding]; other site
228400004961	Substrate binding site [chemical binding]; other site
228400004962	arginine repressor; Provisional; Region: PRK05066
228400004963	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
228400004964	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
228400004965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
228400004966	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
228400004967	NAD(P) binding site [chemical binding]; other site
228400004968	active site
228400004969	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400004970	trimer interface [polypeptide binding]; other site
228400004971	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400004972	trimer interface [polypeptide binding]; other site
228400004973	YadA-like C-terminal region; Region: YadA; pfam03895
228400004974	electron transport complex protein RsxA; Provisional; Region: PRK05151
228400004975	ferredoxin; Provisional; Region: PRK08764
228400004976	Putative Fe-S cluster; Region: FeS; cl17515
228400004977	4Fe-4S binding domain; Region: Fer4; pfam00037
228400004978	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
228400004979	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
228400004980	SLBB domain; Region: SLBB; pfam10531
228400004981	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
228400004982	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
228400004983	electron transport complex protein RnfG; Validated; Region: PRK01908
228400004984	electron transport complex RsxE subunit; Provisional; Region: PRK12405
228400004985	endonuclease III; Provisional; Region: PRK10702
228400004986	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
228400004987	minor groove reading motif; other site
228400004988	helix-hairpin-helix signature motif; other site
228400004989	substrate binding pocket [chemical binding]; other site
228400004990	active site
228400004991	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
228400004992	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
228400004993	Na2 binding site [ion binding]; other site
228400004994	putative substrate binding site 1 [chemical binding]; other site
228400004995	Na binding site 1 [ion binding]; other site
228400004996	putative substrate binding site 2 [chemical binding]; other site
228400004997	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
228400004998	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
228400004999	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
228400005000	mce related protein; Region: MCE; pfam02470
228400005001	mce related protein; Region: MCE; pfam02470
228400005002	mce related protein; Region: MCE; pfam02470
228400005003	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
228400005004	Paraquat-inducible protein A; Region: PqiA; pfam04403
228400005005	Paraquat-inducible protein A; Region: PqiA; pfam04403
228400005006	ProP expression regulator; Provisional; Region: PRK04950
228400005007	ProQ/FINO family; Region: ProQ; smart00945
228400005008	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
228400005009	carboxy-terminal protease; Provisional; Region: PRK11186
228400005010	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
228400005011	protein binding site [polypeptide binding]; other site
228400005012	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
228400005013	Catalytic dyad [active]
228400005014	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
228400005015	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
228400005016	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
228400005017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
228400005018	Peptidase M15; Region: Peptidase_M15_3; cl01194
228400005019	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
228400005020	seryl-tRNA synthetase; Provisional; Region: PRK05431
228400005021	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
228400005022	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
228400005023	dimer interface [polypeptide binding]; other site
228400005024	active site
228400005025	motif 1; other site
228400005026	motif 2; other site
228400005027	motif 3; other site
228400005028	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
228400005029	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
228400005030	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
228400005031	putative active site [active]
228400005032	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
228400005033	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
228400005034	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
228400005035	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
228400005036	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
228400005037	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
228400005038	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
228400005039	active site
228400005040	metal binding site [ion binding]; metal-binding site
228400005041	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
228400005042	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
228400005043	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
228400005044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
228400005045	ATP binding site [chemical binding]; other site
228400005046	Mg2+ binding site [ion binding]; other site
228400005047	G-X-G motif; other site
228400005048	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
228400005049	ATP binding site [chemical binding]; other site
228400005050	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
228400005051	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
228400005052	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
228400005053	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400005054	trimer interface [polypeptide binding]; other site
228400005055	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400005056	trimer interface [polypeptide binding]; other site
228400005057	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400005058	trimer interface [polypeptide binding]; other site
228400005059	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400005060	trimer interface [polypeptide binding]; other site
228400005061	Haemagglutinin; Region: HIM; pfam05662
228400005062	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400005063	trimer interface [polypeptide binding]; other site
228400005064	YadA-like C-terminal region; Region: YadA; pfam03895
228400005065	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
228400005066	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
228400005067	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400005068	FeS/SAM binding site; other site
228400005069	TRAM domain; Region: TRAM; pfam01938
228400005070	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
228400005071	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
228400005072	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
228400005073	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
228400005074	Walker A/P-loop; other site
228400005075	ATP binding site [chemical binding]; other site
228400005076	Q-loop/lid; other site
228400005077	ABC transporter signature motif; other site
228400005078	Walker B; other site
228400005079	D-loop; other site
228400005080	H-loop/switch region; other site
228400005081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400005082	dimer interface [polypeptide binding]; other site
228400005083	conserved gate region; other site
228400005084	putative PBP binding loops; other site
228400005085	ABC-ATPase subunit interface; other site
228400005086	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
228400005087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
228400005088	dimer interface [polypeptide binding]; other site
228400005089	conserved gate region; other site
228400005090	ABC-ATPase subunit interface; other site
228400005091	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
228400005092	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
228400005093	transcription-repair coupling factor; Provisional; Region: PRK10689
228400005094	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
228400005095	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400005096	ATP binding site [chemical binding]; other site
228400005097	putative Mg++ binding site [ion binding]; other site
228400005098	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400005099	nucleotide binding region [chemical binding]; other site
228400005100	ATP-binding site [chemical binding]; other site
228400005101	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
228400005102	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
228400005103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400005104	S-adenosylmethionine binding site [chemical binding]; other site
228400005105	DNA gyrase subunit A; Validated; Region: PRK05560
228400005106	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
228400005107	CAP-like domain; other site
228400005108	active site
228400005109	primary dimer interface [polypeptide binding]; other site
228400005110	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
228400005111	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
228400005112	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
228400005113	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
228400005114	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
228400005115	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
228400005116	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
228400005117	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
228400005118	PhnA protein; Region: PhnA; pfam03831
228400005119	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
228400005120	aromatic amino acid transport protein; Region: araaP; TIGR00837
228400005121	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
228400005122	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
228400005123	hinge; other site
228400005124	active site
228400005125	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
228400005126	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
228400005127	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
228400005128	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
228400005129	mce related protein; Region: MCE; pfam02470
228400005130	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
228400005131	conserved hypothetical integral membrane protein; Region: TIGR00056
228400005132	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
228400005133	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
228400005134	Walker A/P-loop; other site
228400005135	ATP binding site [chemical binding]; other site
228400005136	Q-loop/lid; other site
228400005137	ABC transporter signature motif; other site
228400005138	Walker B; other site
228400005139	D-loop; other site
228400005140	H-loop/switch region; other site
228400005141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
228400005142	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
228400005143	OstA-like protein; Region: OstA; cl00844
228400005144	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
228400005145	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
228400005146	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
228400005147	Walker A/P-loop; other site
228400005148	ATP binding site [chemical binding]; other site
228400005149	Q-loop/lid; other site
228400005150	ABC transporter signature motif; other site
228400005151	Walker B; other site
228400005152	D-loop; other site
228400005153	H-loop/switch region; other site
228400005154	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
228400005155	active site
228400005156	phosphorylation site [posttranslational modification]
228400005157	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
228400005158	AAA domain; Region: AAA_18; pfam13238
228400005159	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
228400005160	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
228400005161	active site
228400005162	HIGH motif; other site
228400005163	KMSKS motif; other site
228400005164	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
228400005165	tRNA binding surface [nucleotide binding]; other site
228400005166	anticodon binding site; other site
228400005167	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
228400005168	dimer interface [polypeptide binding]; other site
228400005169	putative tRNA-binding site [nucleotide binding]; other site
228400005170	antiporter inner membrane protein; Provisional; Region: PRK11670
228400005171	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
228400005172	Walker A motif; other site
228400005173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
228400005174	RelB antitoxin; Region: RelB; pfam04221
228400005175	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
228400005176	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
228400005177	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
228400005178	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
228400005179	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
228400005180	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
228400005181	Dehydroquinase class II; Region: DHquinase_II; pfam01220
228400005182	active site
228400005183	trimer interface [polypeptide binding]; other site
228400005184	dimer interface [polypeptide binding]; other site
228400005185	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
228400005186	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
228400005187	carboxyltransferase (CT) interaction site; other site
228400005188	biotinylation site [posttranslational modification]; other site
228400005189	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
228400005190	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
228400005191	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
228400005192	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
228400005193	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
228400005194	Na binding site [ion binding]; other site
228400005195	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
228400005196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
228400005197	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
228400005198	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
228400005199	FMN binding site [chemical binding]; other site
228400005200	active site
228400005201	catalytic residues [active]
228400005202	substrate binding site [chemical binding]; other site
228400005203	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
228400005204	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
228400005205	O-succinylbenzoate synthase; Provisional; Region: PRK05105
228400005206	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
228400005207	active site
228400005208	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
228400005209	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
228400005210	substrate binding site [chemical binding]; other site
228400005211	oxyanion hole (OAH) forming residues; other site
228400005212	trimer interface [polypeptide binding]; other site
228400005213	enolase; Provisional; Region: eno; PRK00077
228400005214	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
228400005215	dimer interface [polypeptide binding]; other site
228400005216	metal binding site [ion binding]; metal-binding site
228400005217	substrate binding pocket [chemical binding]; other site
228400005218	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400005219	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
228400005220	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
228400005221	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400005222	ATP binding site [chemical binding]; other site
228400005223	putative Mg++ binding site [ion binding]; other site
228400005224	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
228400005225	Abi-like protein; Region: Abi_2; cl01988
228400005226	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
228400005227	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400005228	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400005229	Fic/DOC family; Region: Fic; pfam02661
228400005230	HsdM N-terminal domain; Region: HsdM_N; pfam12161
228400005231	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
228400005232	Methyltransferase domain; Region: Methyltransf_26; pfam13659
228400005233	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400005234	integron integrase; Region: integrase_gron; TIGR02249
228400005235	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
228400005236	Int/Topo IB signature motif; other site
228400005237	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
228400005238	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
228400005239	Acyltransferase family; Region: Acyl_transf_3; pfam01757
228400005240	Transposase IS200 like; Region: Y1_Tnp; pfam01797
228400005241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
228400005242	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
228400005243	Probable transposase; Region: OrfB_IS605; pfam01385
228400005244	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
228400005245	Ash protein family; Region: Phage_ASH; pfam10554
228400005246	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
228400005247	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
228400005248	Probable transposase; Region: OrfB_IS605; pfam01385
228400005249	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
228400005250	Transposase IS200 like; Region: Y1_Tnp; pfam01797
228400005251	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
228400005252	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
228400005253	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
228400005254	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
228400005255	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
228400005256	Cytotoxic; Region: Cytotoxic; pfam09000
228400005257	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
228400005258	Protein of unknown function, DUF600; Region: DUF600; cl04640
228400005259	haemagglutination activity domain; Region: Haemagg_act; pfam05860
228400005260	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
228400005261	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
228400005262	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
228400005263	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
228400005264	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
228400005265	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
228400005266	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
228400005267	hypothetical protein; Provisional; Region: PRK11212
228400005268	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
228400005269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400005270	S-adenosylmethionine binding site [chemical binding]; other site
228400005271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
228400005272	SCP-2 sterol transfer family; Region: SCP2; pfam02036
228400005273	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
228400005274	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
228400005275	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
228400005276	sec-independent translocase; Provisional; Region: PRK01770
228400005277	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
228400005278	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
228400005279	dimer interface [polypeptide binding]; other site
228400005280	allosteric magnesium binding site [ion binding]; other site
228400005281	active site
228400005282	aspartate-rich active site metal binding site; other site
228400005283	Schiff base residues; other site
228400005284	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
228400005285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
228400005286	ATP-grasp domain; Region: ATP-grasp; pfam02222
228400005287	S-ribosylhomocysteinase; Provisional; Region: PRK02260
228400005288	transketolase; Reviewed; Region: PRK12753
228400005289	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
228400005290	TPP-binding site [chemical binding]; other site
228400005291	dimer interface [polypeptide binding]; other site
228400005292	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
228400005293	PYR/PP interface [polypeptide binding]; other site
228400005294	dimer interface [polypeptide binding]; other site
228400005295	TPP binding site [chemical binding]; other site
228400005296	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
228400005297	Predicted helicase [General function prediction only]; Region: COG4889
228400005298	DEAD-like helicases superfamily; Region: DEXDc; smart00487
228400005299	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400005300	ATP binding site [chemical binding]; other site
228400005301	putative Mg++ binding site [ion binding]; other site
228400005302	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
228400005303	ATP-binding site [chemical binding]; other site
228400005304	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
228400005305	CTP synthetase; Validated; Region: pyrG; PRK05380
228400005306	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
228400005307	Catalytic site [active]
228400005308	active site
228400005309	UTP binding site [chemical binding]; other site
228400005310	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
228400005311	active site
228400005312	putative oxyanion hole; other site
228400005313	catalytic triad [active]
228400005314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
228400005315	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
228400005316	Probable transposase; Region: OrfB_IS605; pfam01385
228400005317	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
228400005318	Transposase IS200 like; Region: Y1_Tnp; pfam01797
228400005319	Helix-turn-helix domain; Region: HTH_39; pfam14090
228400005320	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
228400005321	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
228400005322	integrase; Provisional; Region: PRK09692
228400005323	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
228400005324	active site
228400005325	Int/Topo IB signature motif; other site
228400005326	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
228400005327	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
228400005328	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
228400005329	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
228400005330	active site
228400005331	catalytic residues [active]
228400005332	DNA binding site [nucleotide binding]
228400005333	Int/Topo IB signature motif; other site
228400005334	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
228400005335	Helix-turn-helix domain; Region: HTH_38; pfam13936
228400005336	Integrase core domain; Region: rve; pfam00665
228400005337	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
228400005338	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
228400005339	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
228400005340	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
228400005341	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
228400005342	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
228400005343	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
228400005344	catalytic residue [active]
228400005345	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
228400005346	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
228400005347	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
228400005348	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
228400005349	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
228400005350	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
228400005351	Protein of unknown function (DUF2895); Region: DUF2895; pfam11444
228400005352	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
228400005353	Protein of unknown function (DUF2976); Region: DUF2976; pfam11190
228400005354	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
228400005355	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
228400005356	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
228400005357	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
228400005358	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
228400005359	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
228400005360	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
228400005361	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
228400005362	catalytic residue [active]
228400005363	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
228400005364	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
228400005365	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
228400005366	DNA topoisomerase III; Provisional; Region: PRK07726
228400005367	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
228400005368	active site
228400005369	putative interdomain interaction site [polypeptide binding]; other site
228400005370	putative metal-binding site [ion binding]; other site
228400005371	putative nucleotide binding site [chemical binding]; other site
228400005372	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
228400005373	domain I; other site
228400005374	DNA binding groove [nucleotide binding]
228400005375	phosphate binding site [ion binding]; other site
228400005376	domain II; other site
228400005377	domain III; other site
228400005378	nucleotide binding site [chemical binding]; other site
228400005379	catalytic site [active]
228400005380	domain IV; other site
228400005381	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
228400005382	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
228400005383	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
228400005384	active site
228400005385	Predicted metal-binding protein [General function prediction only]; Region: COG3019
228400005386	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
228400005387	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
228400005388	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
228400005389	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
228400005390	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
228400005391	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
228400005392	DNA binding residues [nucleotide binding]
228400005393	dimer interface [polypeptide binding]; other site
228400005394	copper binding site [ion binding]; other site
228400005395	Protein of unknown function, DUF; Region: DUF411; cl01142
228400005396	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
228400005397	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
228400005398	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
228400005399	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
228400005400	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
228400005401	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
228400005402	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
228400005403	motif II; other site
228400005404	Domain of unknown function (DUF305); Region: DUF305; pfam03713
228400005405	NADH kinase; Region: PLN02929
228400005406	tetracycline repressor protein TetR; Provisional; Region: PRK13756
228400005407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
228400005408	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
228400005409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400005410	Major Facilitator Superfamily; Region: MFS_1; pfam07690
228400005411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400005412	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
228400005413	Transcriptional regulators [Transcription]; Region: MarR; COG1846
228400005414	MarR family; Region: MarR_2; pfam12802
228400005415	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
228400005416	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
228400005417	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
228400005418	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
228400005419	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
228400005420	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
228400005421	DNA binding residues [nucleotide binding]
228400005422	dimer interface [polypeptide binding]; other site
228400005423	putative metal binding site [ion binding]; other site
228400005424	Sodium Bile acid symporter family; Region: SBF; cl17470
228400005425	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
228400005426	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
228400005427	putative NAD(P) binding site [chemical binding]; other site
228400005428	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
228400005429	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
228400005430	dimer interface [polypeptide binding]; other site
228400005431	ssDNA binding site [nucleotide binding]; other site
228400005432	tetramer (dimer of dimers) interface [polypeptide binding]; other site
228400005433	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
228400005434	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
228400005435	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
228400005436	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
228400005437	ParB-like nuclease domain; Region: ParBc; pfam02195
228400005438	replicative DNA helicase; Region: DnaB; TIGR00665
228400005439	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
228400005440	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
228400005441	Walker A motif; other site
228400005442	ATP binding site [chemical binding]; other site
228400005443	Walker B motif; other site
228400005444	DNA binding loops [nucleotide binding]
228400005445	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
228400005446	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
228400005447	P-loop; other site
228400005448	Magnesium ion binding site [ion binding]; other site
228400005449	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
228400005450	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
228400005451	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
228400005452	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
228400005453	multifunctional aminopeptidase A; Provisional; Region: PRK00913
228400005454	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
228400005455	interface (dimer of trimers) [polypeptide binding]; other site
228400005456	Substrate-binding/catalytic site; other site
228400005457	Zn-binding sites [ion binding]; other site
228400005458	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
228400005459	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
228400005460	putative DNA binding site [nucleotide binding]; other site
228400005461	putative Zn2+ binding site [ion binding]; other site
228400005462	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
228400005463	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
228400005464	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
228400005465	Cysteine-rich domain; Region: CCG; pfam02754
228400005466	Cysteine-rich domain; Region: CCG; pfam02754
228400005467	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
228400005468	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
228400005469	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
228400005470	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
228400005471	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
228400005472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400005473	putative substrate translocation pore; other site
228400005474	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
228400005475	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
228400005476	active site
228400005477	catalytic site [active]
228400005478	metal binding site [ion binding]; metal-binding site
228400005479	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
228400005480	active site
228400005481	putative DNA-binding cleft [nucleotide binding]; other site
228400005482	dimer interface [polypeptide binding]; other site
228400005483	hypothetical protein; Validated; Region: PRK00110
228400005484	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
228400005485	nudix motif; other site
228400005486	hypothetical protein; Validated; Region: PRK01777
228400005487	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
228400005488	putative coenzyme Q binding site [chemical binding]; other site
228400005489	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
228400005490	putative active site [active]
228400005491	catalytic residue [active]
228400005492	GTP-binding protein YchF; Reviewed; Region: PRK09601
228400005493	YchF GTPase; Region: YchF; cd01900
228400005494	G1 box; other site
228400005495	GTP/Mg2+ binding site [chemical binding]; other site
228400005496	Switch I region; other site
228400005497	G2 box; other site
228400005498	Switch II region; other site
228400005499	G3 box; other site
228400005500	G4 box; other site
228400005501	G5 box; other site
228400005502	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
228400005503	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
228400005504	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
228400005505	dimer interface [polypeptide binding]; other site
228400005506	active site
228400005507	metal binding site [ion binding]; metal-binding site
228400005508	glutathione binding site [chemical binding]; other site
228400005509	ribonuclease T; Provisional; Region: PRK05168
228400005510	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
228400005511	active site
228400005512	catalytic site [active]
228400005513	substrate binding site [chemical binding]; other site
228400005514	FtsI repressor; Provisional; Region: PRK10883
228400005515	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
228400005516	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
228400005517	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
228400005518	putative acyl-acceptor binding pocket; other site
228400005519	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
228400005520	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
228400005521	putative active site [active]
228400005522	putative metal binding site [ion binding]; other site
228400005523	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
228400005524	Part of AAA domain; Region: AAA_19; pfam13245
228400005525	Family description; Region: UvrD_C_2; pfam13538
228400005526	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
228400005527	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
228400005528	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
228400005529	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
228400005530	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
228400005531	dimerization interface [polypeptide binding]; other site
228400005532	substrate binding pocket [chemical binding]; other site
228400005533	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
228400005534	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
228400005535	homodimer interface [polypeptide binding]; other site
228400005536	substrate-cofactor binding pocket; other site
228400005537	catalytic residue [active]
228400005538	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
228400005539	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
228400005540	catalytic triad [active]
228400005541	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
228400005542	dihydrodipicolinate synthase; Region: dapA; TIGR00674
228400005543	dimer interface [polypeptide binding]; other site
228400005544	active site
228400005545	catalytic residue [active]
228400005546	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
228400005547	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
228400005548	DNA polymerase III subunit psi; Validated; Region: PRK06856
228400005549	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
228400005550	Found in ATP-dependent protease La (LON); Region: LON; smart00464
228400005551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400005552	Walker A motif; other site
228400005553	ATP binding site [chemical binding]; other site
228400005554	Walker B motif; other site
228400005555	arginine finger; other site
228400005556	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
228400005557	FtsH protease regulator HflC; Provisional; Region: PRK11029
228400005558	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
228400005559	FtsH protease regulator HflK; Provisional; Region: PRK10930
228400005560	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
228400005561	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
228400005562	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
228400005563	active site
228400005564	ADP/pyrophosphate binding site [chemical binding]; other site
228400005565	dimerization interface [polypeptide binding]; other site
228400005566	allosteric effector site; other site
228400005567	fructose-1,6-bisphosphate binding site; other site
228400005568	Cation efflux family; Region: Cation_efflux; cl00316
228400005569	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
228400005570	META domain; Region: META; cl01245
228400005571	hypothetical protein; Validated; Region: PRK02101
228400005572	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
228400005573	ligand binding site [chemical binding]; other site
228400005574	active site
228400005575	UGI interface [polypeptide binding]; other site
228400005576	catalytic site [active]
228400005577	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
228400005578	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
228400005579	DALR anticodon binding domain; Region: DALR_1; pfam05746
228400005580	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
228400005581	trimer interface [polypeptide binding]; other site
228400005582	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400005583	trimer interface [polypeptide binding]; other site
228400005584	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400005585	trimer interface [polypeptide binding]; other site
228400005586	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400005587	trimer interface [polypeptide binding]; other site
228400005588	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
228400005589	trimer interface [polypeptide binding]; other site
228400005590	YadA-like C-terminal region; Region: YadA; pfam03895
228400005591	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
228400005592	DsrH like protein; Region: DsrH; cl17347
228400005593	sulfur relay protein TusC; Validated; Region: PRK00211
228400005594	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
228400005595	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
228400005596	YheO-like PAS domain; Region: PAS_6; pfam08348
228400005597	HTH domain; Region: HTH_22; pfam13309
228400005598	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
228400005599	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
228400005600	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
228400005601	hypothetical protein; Provisional; Region: PRK02119
228400005602	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
228400005603	nudix motif; other site
228400005604	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
228400005605	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
228400005606	active site
228400005607	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
228400005608	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
228400005609	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
228400005610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
228400005611	Putative esterase; Region: Esterase; pfam00756
228400005612	elongation factor Tu; Reviewed; Region: PRK00049
228400005613	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
228400005614	G1 box; other site
228400005615	GEF interaction site [polypeptide binding]; other site
228400005616	GTP/Mg2+ binding site [chemical binding]; other site
228400005617	Switch I region; other site
228400005618	G2 box; other site
228400005619	G3 box; other site
228400005620	Switch II region; other site
228400005621	G4 box; other site
228400005622	G5 box; other site
228400005623	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
228400005624	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
228400005625	Antibiotic Binding Site [chemical binding]; other site
228400005626	elongation factor G; Reviewed; Region: PRK00007
228400005627	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
228400005628	G1 box; other site
228400005629	putative GEF interaction site [polypeptide binding]; other site
228400005630	GTP/Mg2+ binding site [chemical binding]; other site
228400005631	Switch I region; other site
228400005632	G2 box; other site
228400005633	G3 box; other site
228400005634	Switch II region; other site
228400005635	G4 box; other site
228400005636	G5 box; other site
228400005637	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
228400005638	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
228400005639	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
228400005640	30S ribosomal protein S7; Validated; Region: PRK05302
228400005641	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
228400005642	S17 interaction site [polypeptide binding]; other site
228400005643	S8 interaction site; other site
228400005644	16S rRNA interaction site [nucleotide binding]; other site
228400005645	streptomycin interaction site [chemical binding]; other site
228400005646	23S rRNA interaction site [nucleotide binding]; other site
228400005647	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
228400005648	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
228400005649	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
228400005650	dimerization interface [polypeptide binding]; other site
228400005651	domain crossover interface; other site
228400005652	redox-dependent activation switch; other site
228400005653	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
228400005654	RNA binding surface [nucleotide binding]; other site
228400005655	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
228400005656	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
228400005657	active site
228400005658	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
228400005659	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
228400005660	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
228400005661	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
228400005662	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
228400005663	putative active site [active]
228400005664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
228400005665	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
228400005666	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
228400005667	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
228400005668	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
228400005669	hypothetical protein; Validated; Region: PRK05445
228400005670	hypothetical protein; Validated; Region: PRK05090
228400005671	YGGT family; Region: YGGT; pfam02325
228400005672	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
228400005673	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
228400005674	Cl binding site [ion binding]; other site
228400005675	oligomer interface [polypeptide binding]; other site
228400005676	hypothetical protein; Provisional; Region: PRK11702
228400005677	Transcriptional regulator [Transcription]; Region: LysR; COG0583
228400005678	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
228400005679	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
228400005680	putative dimerization interface [polypeptide binding]; other site
228400005681	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
228400005682	catalytic core [active]
228400005683	Domain of unknown function DUF302; Region: DUF302; cl01364
228400005684	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
228400005685	adenine DNA glycosylase; Provisional; Region: PRK10880
228400005686	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
228400005687	minor groove reading motif; other site
228400005688	helix-hairpin-helix signature motif; other site
228400005689	substrate binding pocket [chemical binding]; other site
228400005690	active site
228400005691	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
228400005692	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
228400005693	DNA binding and oxoG recognition site [nucleotide binding]
228400005694	oxidative damage protection protein; Provisional; Region: PRK05408
228400005695	murein transglycosylase C; Provisional; Region: mltC; PRK11671
228400005696	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
228400005697	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
228400005698	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
228400005699	N-acetyl-D-glucosamine binding site [chemical binding]; other site
228400005700	catalytic residue [active]
228400005701	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
228400005702	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
228400005703	active site
228400005704	substrate binding site [chemical binding]; other site
228400005705	metal binding site [ion binding]; metal-binding site
228400005706	ketol-acid reductoisomerase; Validated; Region: PRK05225
228400005707	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
228400005708	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
228400005709	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
228400005710	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
228400005711	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
228400005712	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
228400005713	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
228400005714	molybdopterin cofactor binding site [chemical binding]; other site
228400005715	substrate binding site [chemical binding]; other site
228400005716	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
228400005717	molybdopterin cofactor binding site; other site
228400005718	chaperone protein TorD; Validated; Region: torD; PRK04976
228400005719	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
228400005720	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
228400005721	Ligand Binding Site [chemical binding]; other site
228400005722	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
228400005723	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
228400005724	ApbE family; Region: ApbE; pfam02424
228400005725	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
228400005726	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
228400005727	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
228400005728	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
228400005729	FAD binding pocket [chemical binding]; other site
228400005730	FAD binding motif [chemical binding]; other site
228400005731	phosphate binding motif [ion binding]; other site
228400005732	beta-alpha-beta structure motif; other site
228400005733	NAD binding pocket [chemical binding]; other site
228400005734	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
228400005735	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
228400005736	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
228400005737	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
228400005738	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
228400005739	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
228400005740	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
228400005741	E3 interaction surface; other site
228400005742	lipoyl attachment site [posttranslational modification]; other site
228400005743	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
228400005744	BolA-like protein; Region: BolA; cl00386
228400005745	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
228400005746	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
228400005747	gamma subunit interface [polypeptide binding]; other site
228400005748	epsilon subunit interface [polypeptide binding]; other site
228400005749	LBP interface [polypeptide binding]; other site
228400005750	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
228400005751	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
228400005752	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
228400005753	alpha subunit interaction interface [polypeptide binding]; other site
228400005754	Walker A motif; other site
228400005755	ATP binding site [chemical binding]; other site
228400005756	Walker B motif; other site
228400005757	inhibitor binding site; inhibition site
228400005758	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
228400005759	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
228400005760	core domain interface [polypeptide binding]; other site
228400005761	delta subunit interface [polypeptide binding]; other site
228400005762	epsilon subunit interface [polypeptide binding]; other site
228400005763	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
228400005764	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
228400005765	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
228400005766	beta subunit interaction interface [polypeptide binding]; other site
228400005767	Walker A motif; other site
228400005768	ATP binding site [chemical binding]; other site
228400005769	Walker B motif; other site
228400005770	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
228400005771	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
228400005772	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
228400005773	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
228400005774	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
228400005775	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
228400005776	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
228400005777	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
228400005778	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
228400005779	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
228400005780	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
228400005781	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
228400005782	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
228400005783	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
228400005784	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
228400005785	FMN-binding protein MioC; Provisional; Region: PRK09004
228400005786	Protein of unknown function (DUF904); Region: DUF904; pfam06005
228400005787	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
228400005788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
228400005789	ATP binding site [chemical binding]; other site
228400005790	Mg2+ binding site [ion binding]; other site
228400005791	G-X-G motif; other site
228400005792	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
228400005793	anchoring element; other site
228400005794	dimer interface [polypeptide binding]; other site
228400005795	ATP binding site [chemical binding]; other site
228400005796	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
228400005797	active site
228400005798	putative metal-binding site [ion binding]; other site
228400005799	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
228400005800	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
228400005801	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
228400005802	ATP binding site [chemical binding]; other site
228400005803	putative Mg++ binding site [ion binding]; other site
228400005804	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
228400005805	nucleotide binding region [chemical binding]; other site
228400005806	ATP-binding site [chemical binding]; other site
228400005807	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
228400005808	Helicase and RNase D C-terminal; Region: HRDC; smart00341
228400005809	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
228400005810	putative iron binding site [ion binding]; other site
228400005811	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
228400005812	diaminopimelate decarboxylase; Region: lysA; TIGR01048
228400005813	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
228400005814	active site
228400005815	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
228400005816	substrate binding site [chemical binding]; other site
228400005817	catalytic residues [active]
228400005818	dimer interface [polypeptide binding]; other site
228400005819	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
228400005820	Na2 binding site [ion binding]; other site
228400005821	putative substrate binding site 1 [chemical binding]; other site
228400005822	Na binding site 1 [ion binding]; other site
228400005823	putative substrate binding site 2 [chemical binding]; other site
228400005824	TfoX N-terminal domain; Region: TfoX_N; pfam04993
228400005825	TfoX C-terminal domain; Region: TfoX_C; pfam04994
228400005826	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
228400005827	dimerization interface [polypeptide binding]; other site
228400005828	substrate binding pocket [chemical binding]; other site
228400005829	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400005830	non-specific DNA binding site [nucleotide binding]; other site
228400005831	salt bridge; other site
228400005832	sequence-specific DNA binding site [nucleotide binding]; other site
228400005833	Predicted transcriptional regulator [Transcription]; Region: COG2932
228400005834	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
228400005835	Catalytic site [active]
228400005836	Predicted transcriptional regulator [Transcription]; Region: Nlp; COG3423
228400005837	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
228400005838	Integrase core domain; Region: rve; pfam00665
228400005839	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
228400005840	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
228400005841	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
228400005842	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
228400005843	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400005844	non-specific DNA binding site [nucleotide binding]; other site
228400005845	salt bridge; other site
228400005846	sequence-specific DNA binding site [nucleotide binding]; other site
228400005847	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
228400005848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400005849	S-adenosylmethionine binding site [chemical binding]; other site
228400005850	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
228400005851	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
228400005852	Transposase domain (DUF772); Region: DUF772; pfam05598
228400005853	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
228400005854	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
228400005855	Walker A motif; other site
228400005856	ATP binding site [chemical binding]; other site
228400005857	Walker B motif; other site
228400005858	arginine finger; other site
228400005859	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
228400005860	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
228400005861	active site
228400005862	catalytic triad [active]
228400005863	fructuronate transporter; Provisional; Region: PRK10034; cl15264
228400005864	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
228400005865	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
228400005866	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
228400005867	catalytic residue [active]
228400005868	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
228400005869	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
228400005870	active site
228400005871	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
228400005872	active site
228400005873	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
228400005874	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
228400005875	metal binding site [ion binding]; metal-binding site
228400005876	dimer interface [polypeptide binding]; other site
228400005877	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
228400005878	MutS domain I; Region: MutS_I; pfam01624
228400005879	MutS domain II; Region: MutS_II; pfam05188
228400005880	MutS domain III; Region: MutS_III; pfam05192
228400005881	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
228400005882	Walker A/P-loop; other site
228400005883	ATP binding site [chemical binding]; other site
228400005884	Q-loop/lid; other site
228400005885	ABC transporter signature motif; other site
228400005886	Walker B; other site
228400005887	D-loop; other site
228400005888	H-loop/switch region; other site
228400005889	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
228400005890	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
228400005891	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
228400005892	shikimate binding site; other site
228400005893	NAD(P) binding site [chemical binding]; other site
228400005894	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
228400005895	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
228400005896	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
228400005897	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
228400005898	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
228400005899	hypothetical protein; Validated; Region: PRK00228
228400005900	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
228400005901	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
228400005902	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
228400005903	DNA-binding site [nucleotide binding]; DNA binding site
228400005904	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
228400005905	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
228400005906	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
228400005907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
228400005908	putative aldolase; Validated; Region: PRK08130
228400005909	intersubunit interface [polypeptide binding]; other site
228400005910	active site
228400005911	Zn2+ binding site [ion binding]; other site
228400005912	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
228400005913	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
228400005914	Metal-binding active site; metal-binding site
228400005915	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
228400005916	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
228400005917	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
228400005918	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
228400005919	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
228400005920	putative NAD(P) binding site [chemical binding]; other site
228400005921	active site
228400005922	putative substrate binding site [chemical binding]; other site
228400005923	GntP family permease; Region: GntP_permease; pfam02447
228400005924	fructuronate transporter; Provisional; Region: PRK10034; cl15264
228400005925	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
228400005926	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
228400005927	ATP binding site [chemical binding]; other site
228400005928	substrate interface [chemical binding]; other site
228400005929	Major Facilitator Superfamily; Region: MFS_1; pfam07690
228400005930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
228400005931	putative substrate translocation pore; other site
228400005932	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
228400005933	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
228400005934	DNA-binding site [nucleotide binding]; DNA binding site
228400005935	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
228400005936	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
228400005937	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
228400005938	putative NAD(P) binding site [chemical binding]; other site
228400005939	catalytic Zn binding site [ion binding]; other site
228400005940	structural Zn binding site [ion binding]; other site
228400005941	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
228400005942	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
228400005943	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
228400005944	DctM-like transporters; Region: DctM; pfam06808
228400005945	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
228400005946	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
228400005947	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
228400005948	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
228400005949	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
228400005950	putative active site [active]
228400005951	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
228400005952	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
228400005953	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
228400005954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
228400005955	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
228400005956	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
228400005957	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
228400005958	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400005959	Walker A/P-loop; other site
228400005960	ATP binding site [chemical binding]; other site
228400005961	Q-loop/lid; other site
228400005962	ABC transporter signature motif; other site
228400005963	Walker B; other site
228400005964	D-loop; other site
228400005965	H-loop/switch region; other site
228400005966	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400005967	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400005968	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400005969	TM-ABC transporter signature motif; other site
228400005970	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400005971	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400005972	TM-ABC transporter signature motif; other site
228400005973	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
228400005974	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
228400005975	putative N- and C-terminal domain interface [polypeptide binding]; other site
228400005976	putative active site [active]
228400005977	MgATP binding site [chemical binding]; other site
228400005978	catalytic site [active]
228400005979	metal binding site [ion binding]; metal-binding site
228400005980	putative carbohydrate binding site [chemical binding]; other site
228400005981	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
228400005982	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
228400005983	catalytic triad [active]
228400005984	dimer interface [polypeptide binding]; other site
228400005985	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
228400005986	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
228400005987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
228400005988	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
228400005989	dimerization interface [polypeptide binding]; other site
228400005990	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
228400005991	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
228400005992	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
228400005993	TrkA-N domain; Region: TrkA_N; pfam02254
228400005994	TrkA-C domain; Region: TrkA_C; pfam02080
228400005995	TrkA-N domain; Region: TrkA_N; pfam02254
228400005996	TrkA-C domain; Region: TrkA_C; pfam02080
228400005997	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
228400005998	putative RNA binding site [nucleotide binding]; other site
228400005999	16S rRNA methyltransferase B; Provisional; Region: PRK10901
228400006000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400006001	S-adenosylmethionine binding site [chemical binding]; other site
228400006002	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
228400006003	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
228400006004	putative active site [active]
228400006005	substrate binding site [chemical binding]; other site
228400006006	putative cosubstrate binding site; other site
228400006007	catalytic site [active]
228400006008	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
228400006009	substrate binding site [chemical binding]; other site
228400006010	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
228400006011	active site
228400006012	catalytic residues [active]
228400006013	metal binding site [ion binding]; metal-binding site
228400006014	transcriptional regulator NarP; Provisional; Region: PRK10403
228400006015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
228400006016	active site
228400006017	phosphorylation site [posttranslational modification]
228400006018	intermolecular recognition site; other site
228400006019	dimerization interface [polypeptide binding]; other site
228400006020	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
228400006021	DNA binding residues [nucleotide binding]
228400006022	dimerization interface [polypeptide binding]; other site
228400006023	adenylate cyclase; Provisional; Region: cyaA; PRK09450
228400006024	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
228400006025	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
228400006026	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
228400006027	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
228400006028	domain interfaces; other site
228400006029	active site
228400006030	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
228400006031	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
228400006032	active site
228400006033	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
228400006034	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
228400006035	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
228400006036	HemY protein N-terminus; Region: HemY_N; pfam07219
228400006037	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
228400006038	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
228400006039	FMN binding site [chemical binding]; other site
228400006040	active site
228400006041	catalytic residues [active]
228400006042	substrate binding site [chemical binding]; other site
228400006043	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
228400006044	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
228400006045	putative N- and C-terminal domain interface [polypeptide binding]; other site
228400006046	putative active site [active]
228400006047	putative MgATP binding site [chemical binding]; other site
228400006048	catalytic site [active]
228400006049	metal binding site [ion binding]; metal-binding site
228400006050	putative carbohydrate binding site [chemical binding]; other site
228400006051	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
228400006052	transcriptional regulator LsrR; Provisional; Region: PRK15418
228400006053	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
228400006054	non-specific DNA interactions [nucleotide binding]; other site
228400006055	DNA binding site [nucleotide binding]
228400006056	sequence specific DNA binding site [nucleotide binding]; other site
228400006057	putative cAMP binding site [chemical binding]; other site
228400006058	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
228400006059	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
228400006060	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
228400006061	Walker A/P-loop; other site
228400006062	ATP binding site [chemical binding]; other site
228400006063	Q-loop/lid; other site
228400006064	ABC transporter signature motif; other site
228400006065	Walker B; other site
228400006066	D-loop; other site
228400006067	H-loop/switch region; other site
228400006068	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
228400006069	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400006070	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400006071	TM-ABC transporter signature motif; other site
228400006072	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
228400006073	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
228400006074	TM-ABC transporter signature motif; other site
228400006075	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
228400006076	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
228400006077	ligand binding site [chemical binding]; other site
228400006078	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
228400006079	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
228400006080	putative active site; other site
228400006081	catalytic residue [active]
228400006082	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
228400006083	ribulose-phosphate 3-epimerase; Validated; Region: PRK08091
228400006084	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
228400006085	phosphate binding site [ion binding]; other site
228400006086	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
228400006087	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
228400006088	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
228400006089	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
228400006090	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
228400006091	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
228400006092	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
228400006093	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
228400006094	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
228400006095	protein-rRNA interface [nucleotide binding]; other site
228400006096	putative translocon binding site; other site
228400006097	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
228400006098	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
228400006099	G-X-X-G motif; other site
228400006100	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
228400006101	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
228400006102	23S rRNA interface [nucleotide binding]; other site
228400006103	5S rRNA interface [nucleotide binding]; other site
228400006104	putative antibiotic binding site [chemical binding]; other site
228400006105	L25 interface [polypeptide binding]; other site
228400006106	L27 interface [polypeptide binding]; other site
228400006107	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
228400006108	23S rRNA interface [nucleotide binding]; other site
228400006109	putative translocon interaction site; other site
228400006110	signal recognition particle (SRP54) interaction site; other site
228400006111	L23 interface [polypeptide binding]; other site
228400006112	trigger factor interaction site; other site
228400006113	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
228400006114	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
228400006115	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
228400006116	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
228400006117	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
228400006118	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
228400006119	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
228400006120	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
228400006121	RNA binding site [nucleotide binding]; other site
228400006122	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
228400006123	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
228400006124	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
228400006125	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
228400006126	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
228400006127	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
228400006128	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
228400006129	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
228400006130	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
228400006131	5S rRNA interface [nucleotide binding]; other site
228400006132	23S rRNA interface [nucleotide binding]; other site
228400006133	L5 interface [polypeptide binding]; other site
228400006134	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
228400006135	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
228400006136	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
228400006137	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
228400006138	23S rRNA binding site [nucleotide binding]; other site
228400006139	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
228400006140	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
228400006141	SecY translocase; Region: SecY; pfam00344
228400006142	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
228400006143	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
228400006144	30S ribosomal protein S13; Region: bact_S13; TIGR03631
228400006145	30S ribosomal protein S11; Validated; Region: PRK05309
228400006146	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
228400006147	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
228400006148	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
228400006149	RNA binding surface [nucleotide binding]; other site
228400006150	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
228400006151	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
228400006152	alphaNTD homodimer interface [polypeptide binding]; other site
228400006153	alphaNTD - beta interaction site [polypeptide binding]; other site
228400006154	alphaNTD - beta' interaction site [polypeptide binding]; other site
228400006155	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
228400006156	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
228400006157	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
228400006158	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
228400006159	active site
228400006160	metal binding site [ion binding]; metal-binding site
228400006161	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
228400006162	non-specific DNA binding site [nucleotide binding]; other site
228400006163	salt bridge; other site
228400006164	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
228400006165	sequence-specific DNA binding site [nucleotide binding]; other site
228400006166	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
228400006167	active site
228400006168	(T/H)XGH motif; other site
228400006169	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
228400006170	Membrane fusogenic activity; Region: BMFP; cl01115
228400006171	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
228400006172	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
228400006173	DNA repair protein RecO; Region: reco; TIGR00613
228400006174	Recombination protein O N terminal; Region: RecO_N; pfam11967
228400006175	Recombination protein O C terminal; Region: RecO_C; pfam02565
228400006176	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
228400006177	TRAM domain; Region: TRAM; cl01282
228400006178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
228400006179	S-adenosylmethionine binding site [chemical binding]; other site
228400006180	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
228400006181	HD domain; Region: HD_4; pfam13328
228400006182	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
228400006183	synthetase active site [active]
228400006184	NTP binding site [chemical binding]; other site
228400006185	metal binding site [ion binding]; metal-binding site
228400006186	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
228400006187	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
228400006188	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
228400006189	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
228400006190	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
228400006191	N-terminal plug; other site
228400006192	ligand-binding site [chemical binding]; other site
228400006193	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
228400006194	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
228400006195	dimer interface [polypeptide binding]; other site
228400006196	active site
228400006197	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
228400006198	putative active site 1 [active]
228400006199	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
228400006200	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
228400006201	NAD(P) binding site [chemical binding]; other site
228400006202	homotetramer interface [polypeptide binding]; other site
228400006203	homodimer interface [polypeptide binding]; other site
228400006204	active site
228400006205	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
228400006206	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
228400006207	dimer interface [polypeptide binding]; other site
228400006208	active site
228400006209	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
228400006210	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
228400006211	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
228400006212	putative acyl-acceptor binding pocket; other site
228400006213	Phosphopantetheine attachment site; Region: PP-binding; cl09936
228400006214	acyl carrier protein; Provisional; Region: PRK05350
228400006215	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
228400006216	active site 2 [active]
228400006217	active site 1 [active]
228400006218	Predicted membrane protein [Function unknown]; Region: COG4648
228400006219	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
228400006220	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
228400006221	AMP binding site [chemical binding]; other site
228400006222	active site
228400006223	acyl-activating enzyme (AAE) consensus motif; other site
228400006224	CoA binding site [chemical binding]; other site
228400006225	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
228400006226	Ligand binding site; other site
228400006227	Putative Catalytic site; other site
228400006228	DXD motif; other site
228400006229	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
228400006230	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
228400006231	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
228400006232	putative acyl-acceptor binding pocket; other site
228400006233	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
228400006234	active site
228400006235	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
228400006236	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
228400006237	Predicted exporter [General function prediction only]; Region: COG4258
228400006238	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
228400006239	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
228400006240	ligand binding site [chemical binding]; other site
228400006241	NAD binding site [chemical binding]; other site
228400006242	tetramer interface [polypeptide binding]; other site
228400006243	catalytic site [active]
228400006244	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
228400006245	L-serine binding site [chemical binding]; other site
228400006246	ACT domain interface; other site
228400006247	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
228400006248	tetramer (dimer of dimers) interface [polypeptide binding]; other site
228400006249	active site
228400006250	dimer interface [polypeptide binding]; other site
228400006251	HemN family oxidoreductase; Provisional; Region: PRK05660
228400006252	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
228400006253	FeS/SAM binding site; other site
228400006254	HemN C-terminal domain; Region: HemN_C; pfam06969
228400006255	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
228400006256	active site
228400006257	dimerization interface [polypeptide binding]; other site
228400006258	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
228400006259	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
228400006260	homotrimer interaction site [polypeptide binding]; other site
228400006261	putative active site [active]
228400006262	hypothetical protein; Provisional; Region: PRK07101
228400006263	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
228400006264	substrate-cofactor binding pocket; other site
228400006265	homodimer interface [polypeptide binding]; other site
228400006266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
228400006267	para-aminobenzoate synthase component I; Validated; Region: PRK07093
228400006268	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
228400006269	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
228400006270	Glutamine amidotransferase class-I; Region: GATase; pfam00117
228400006271	glutamine binding [chemical binding]; other site
228400006272	catalytic triad [active]
228400006273	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
228400006274	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
228400006275	dimerization interface [polypeptide binding]; other site
228400006276	DPS ferroxidase diiron center [ion binding]; other site
228400006277	ion pore; other site
228400006278	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
228400006279	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
228400006280	trmE is a tRNA modification GTPase; Region: trmE; cd04164
228400006281	G1 box; other site
228400006282	GTP/Mg2+ binding site [chemical binding]; other site
228400006283	Switch I region; other site
228400006284	G2 box; other site
228400006285	Switch II region; other site
228400006286	G3 box; other site
228400006287	G4 box; other site
228400006288	G5 box; other site
228400006289	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
228400006290	membrane protein insertase; Provisional; Region: PRK01318
228400006291	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
228400006292	hypothetical protein; Validated; Region: PRK00041
228400006293	ribonuclease P; Reviewed; Region: rnpA; PRK01732
228400006294	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399