-- dump date 20140619_105450 -- class Genbank::CDS -- table cds_note -- id note YP_431350.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_431351.1 TIGRFAMsMatches:TIGR00663 YP_431353.1 Predicted unusual protein kinase; COG0661 YP_431354.1 COG2095 YP_431355.1 COG1195 YP_431356.1 negatively supercoils closed circular double-stranded DNA YP_431358.1 COG1124 YP_431359.1 COG0444 YP_431360.1 COG0601 YP_431361.1 COG0747 YP_431363.1 Predicted transcriptional regulator; COG0640 YP_431364.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_431366.1 COG1283 YP_431367.1 COG2133 YP_431368.1 COG0241; similar to related phosphatase YP_431369.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_431370.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_431371.1 COG1560 YP_431373.1 COG0596 YP_431374.1 COG0168 YP_431375.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_431376.1 TIGRFAMsMatches:TIGR00563 YP_431377.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_431378.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_431379.1 COG1652 YP_431380.1 COG0758 YP_431381.1 COG0009 YP_431382.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_431384.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_431385.1 COG1291 YP_431386.1 COG1360 YP_431388.1 COG0071 YP_431389.1 COG0663 YP_431390.1 Zn-dependent oligopeptidase; COG0339 YP_431391.1 COG3529 YP_431393.1 COG0534 YP_431394.1 Heme/copper-type cytochrome/quinol oxidases, subunit 2 COG1622 YP_431395.1 Heme/copper-type cytochrome/quinol oxidases, subunit 1 COG0843 YP_431396.1 Heme/copper-type cytochrome/quinol oxidase, subunit 3; COG1845 YP_431398.1 COG3346 YP_431400.1 COG1612 YP_431401.1 converts protoheme IX and farnesyl diphosphate to heme O YP_431402.1 COG1680 YP_431405.1 Gluconolactonase; COG3386 YP_431408.1 COG3608 YP_431409.1 COG0415 YP_431411.1 COG0745 YP_431412.1 COG0642 YP_431414.1 COG1280 YP_431415.1 COG4977 YP_431416.1 COG0435 YP_431417.1 COG1653 YP_431418.1 TIGRFAMsMatches:TIGR02124 YP_431419.1 TIGRFAMsMatches:TIGR00075 YP_431420.1 TIGRFAMsMatches:TIGR00074 YP_431421.1 TIGRFAMsMatches:TIGR00143 YP_431422.1 TIGRFAMsMatches:TIGR00073 YP_431423.1 COG2200 YP_431426.1 COG0438 YP_431429.1 COG0438 YP_431430.1 COG0840 YP_431432.1 COG5297 YP_431433.1 COG2730 YP_431435.1 COG2304 YP_431436.1 COG3764 YP_431437.1 Retron-type reverse transcriptase; COG3344 YP_431439.1 uncharacterized protein with a C-terminal OMP (outer membrane protein) domain; COG4625 YP_431442.1 COG3220 YP_431444.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_431446.1 COG1054 YP_431447.1 COG2041 YP_431449.1 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) COG0375 YP_431450.1 COG0680 YP_431451.1 COG3259 YP_431452.1 COG1941 YP_431453.1 uncharacterized anaerobic dehydrogenase; COG3383 YP_431454.1 COG1894 YP_431455.1 COG0846 YP_431456.1 COG0386 YP_431459.1 COG2770 YP_431460.1 COG0515 YP_431461.1 COG0226 YP_431463.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_431464.1 COG5373 YP_431465.1 COG0412 YP_431466.1 COG3211 YP_431468.1 COG3239 YP_431469.1 COG2356 YP_431470.1 COG5587 YP_431471.1 COG1028 YP_431472.1 COG1280 YP_431474.1 COG1859 YP_431475.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_431481.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_431482.1 Glycine/D-amino acid oxidases (deaminating) COG0665 YP_431483.1 TIGRFAMsMatches:TIGR01683 YP_431484.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_431485.1 COG0352 YP_431487.1 COG0834 YP_431488.1 COG1132 YP_431494.1 COG0824 YP_431495.1 COG0517 YP_431496.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_431497.1 COG0678 YP_431499.1 COG0724 YP_431502.1 TIGRFAMsMatches:TIGR01389 YP_431503.1 COG1174 YP_431504.1 COG1125 YP_431505.1 COG1174 YP_431506.1 COG1732 YP_431508.1 COG4700 YP_431510.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester YP_431511.1 COG1690 YP_431512.1 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain; COG4650 YP_431513.1 COG1115 YP_431514.1 catalyzes the oxidative deamination of D-amino acids YP_431516.1 COG3541 YP_431517.1 COG2199 YP_431518.1 COG3485 YP_431519.1 COG0388 YP_431523.1 COG3490 YP_431524.1 COG3489 YP_431525.1 COG3488 YP_431526.1 COG3487 YP_431527.1 COG1853 YP_431528.1 COG4185 YP_431530.1 involved in start site selection during the initiation of translation YP_431531.1 COG0429 YP_431532.1 Transcriptional regulator containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs COG1167 YP_431534.1 COG1280 YP_431536.1 COG2378 YP_431538.1 COG0500 YP_431540.1 COG3803 YP_431541.1 Glycosidase; COG0366 YP_431543.1 COG1653 YP_431544.1 COG1175 YP_431545.1 COG0395 YP_431546.1 Glycosidase; COG0366 YP_431547.1 COG3839 YP_431548.1 COG2207 YP_431549.1 COG3785 YP_431550.1 COG0642 YP_431551.1 COG1879 YP_431552.1 translation initiation factor 5A (eIF-5A); Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein YP_431553.1 COG2192 YP_431556.1 COG1741 YP_431557.1 COG0583 YP_431558.1 Di- and tripeptidase; COG2195 YP_431559.1 COG3448 YP_431562.1 TIGRFAMsMatches:TIGR01447 YP_431563.1 TIGRFAMsMatches:TIGR00609 YP_431564.1 TIGRFAMsMatches:TIGR01450 YP_431565.1 COG2866 YP_431566.1 COG3248 YP_431568.1 COG0454 YP_431569.1 COG1100 YP_431570.1 COG4191 YP_431571.1 COG2804 YP_431572.1 COG4938 YP_431575.1 COG0842 YP_431576.1 COG1131 YP_431577.1 COG0845 YP_431579.1 TIGRFAMsMatches:TIGR00476 YP_431580.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_431590.1 COG1523 YP_431591.1 COG1653 YP_431594.1 COG1335 YP_431595.1 COG4977 YP_431596.1 COG1639 YP_431597.1 dTDP-4-dehydrorhamnose reductase; COG1091 YP_431598.1 COG0697 YP_431599.1 COG1714 YP_431600.1 COG1300 YP_431601.1 COG0793 YP_431603.1 COG0714 YP_431604.1 COG1721 YP_431607.1 COG0366 YP_431608.1 COG0463 YP_431609.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_431611.1 COG2206 YP_431612.1 COG2200 YP_431613.1 TIGRFAMsMatches:TIGR01534 YP_431614.1 COG3391 YP_431615.1 COG0834 YP_431616.1 COG0545 YP_431618.1 COG5589 YP_431619.1 COG0488 YP_431620.1 COG0683 YP_431621.1 COG0248 YP_431622.1 TIGRFAMsMatches:TIGR01068 YP_431623.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_431624.1 COG0043 YP_431625.1 catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose YP_431626.1 COG3071 YP_431627.1 COG2959 YP_431628.1 COG1587 YP_431629.1 TIGRFAMsMatches:TIGR00212 YP_431630.1 Response regulator of the LytR/AlgR family; COG3279 YP_431631.1 COG2972 YP_431632.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_431633.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_431634.1 TIGRFAMsMatches:TIGR01048 YP_431635.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_431636.1 COG3159 YP_431637.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_431639.1 COG3706 YP_431640.1 COG0784 YP_431641.1 COG2197 YP_431642.1 COG0642 YP_431646.1 COG0642 YP_431650.1 COG0748 YP_431651.1 COG2945 YP_431652.1 COG0526 YP_431655.1 COG2186 YP_431656.1 COG0334 YP_431658.1 COG3001 YP_431659.1 COG0604 YP_431660.1 COG1376 YP_431662.1 COG4191 YP_431663.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_431664.1 COG2234 YP_431667.1 COG2962 YP_431668.1 COG0069 YP_431672.1 COG1398 YP_431673.1 COG2907 YP_431674.1 COG3496 YP_431675.1 COG2230 YP_431676.1 COG3752 YP_431677.1 COG2230 YP_431681.1 COG5001 YP_431682.1 porin involved in the transport of maltose and maltodextrins YP_431683.1 Represses the expression of the zwf, eda, glp and gap YP_431684.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_431685.1 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; COG0363 YP_431686.1 COG0800 YP_431689.1 COG2170 YP_431691.1 COG3146 YP_431692.1 COG0834 YP_431693.1 COG2374 YP_431695.1 COG2827 YP_431696.1 COG2020 YP_431697.1 COG0596 YP_431698.1 COG1357 YP_431700.1 COG1403 YP_431704.1 COG3706 YP_431711.1 COG0776 YP_431716.1 COG3299 YP_431723.1 COG1734 YP_431730.1 TIGRFAMsMatches:TIGR01551 YP_431731.1 COG1317 YP_431732.1 COG4373 YP_431733.1 TIGRFAMsMatches:TIGR01540 YP_431737.1 DNA polymerase III, epsilon subunit and related 3'-5' exonuclease; COG0847 YP_431741.1 COG0582 YP_431744.1 COG1186 YP_431745.1 COG0737 YP_431746.1 COG0834 YP_431749.1 COG2453 YP_431750.1 COG4663 YP_431751.1 COG4665 YP_431752.1 COG4664 YP_431753.1 COG4564 YP_431754.1 COG2197 YP_431755.1 COG0791 YP_431756.1 COG4551 YP_431759.1 COG1280 YP_431760.1 COG3145 YP_431761.1 COG3217 YP_431762.1 COG4278 YP_431764.1 COG0474 YP_431765.1 COG1801 YP_431766.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_431767.1 TIGRFAMsMatches:TIGR01534 YP_431768.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_431769.1 TIGRFAMsMatches:TIGR00749 YP_431770.1 COG4989 YP_431771.1 COG5544 YP_431772.1 COG1794 YP_431774.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_431775.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_431776.1 with MalKGE is involved in maltose transport into the cell YP_431777.1 with MalKFE is involved in the transport of maltose into the cell YP_431779.1 COG0724 YP_431781.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_431782.1 COG1734 YP_431783.1 COG0784 YP_431784.1 COG0840 YP_431785.1 antagonist of anti-sigma factor; COG1366 YP_431786.1 COG2208 YP_431787.1 COG0426 YP_431788.1 COG0840 YP_431789.1 COG0784 YP_431790.1 COG0643 YP_431791.1 COG0835 YP_431792.1 COG0840 YP_431793.1 COG0840 YP_431794.1 COG0835 YP_431796.1 COG1352 YP_431797.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_431798.1 COG2201 YP_431799.1 COG0454 YP_431800.1 COG2188 YP_431801.1 COG1409 YP_431806.1 COG3209 YP_431807.1 COG3209 YP_431810.1 COG2202 YP_431811.1 COG1670 YP_431813.1 with malEFG is involved in import of maltose/maltodextrin YP_431814.1 COG0366 YP_431815.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_431816.1 COG0697 YP_431817.1 COG0471 YP_431818.1 COG0454 YP_431819.1 COG0679 YP_431820.1 COG1196 YP_431821.1 COG0657 YP_431823.1 COG0386 YP_431824.1 COG2928 YP_431825.1 COG1832 YP_431826.1 COG5001 YP_431827.1 catalyzes the formation of 2-dehydropantoate from (R)-pantoate YP_431831.1 COG0840 YP_431832.1 COG3706 YP_431833.1 COG1846 YP_431835.1 COG3673 YP_431836.1 COG3706 YP_431837.1 COG1858 YP_431839.1 COG0394 YP_431840.1 COG0640 YP_431841.1 COG0394 YP_431842.1 COG0798 YP_431844.1 COG0840 YP_431847.1 COG0583 YP_431848.1 COG0657 YP_431850.1 COG5265 YP_431851.1 COG3812 YP_431852.1 COG1054 YP_431854.1 COG2214 YP_431855.1 COG2961 YP_431856.1 COG1028 YP_431857.1 TIGRFAMsMatches:TIGR00063 YP_431858.1 COG3608 YP_431859.1 COG3471 YP_431862.1 COG2207 YP_431864.1 COG3243 YP_431865.1 COG1108 YP_431866.1 COG1121 YP_431867.1 COG0735 YP_431868.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_431870.1 COG2201 YP_431871.1 COG0643 YP_431872.1 COG1352 YP_431873.1 COG0840 YP_431874.1 COG0835 YP_431875.1 COG0784 YP_431876.1 COG0784 YP_431877.1 TIGRFAMsMatches:TIGR01380 YP_431878.1 COG0810 YP_431879.1 COG1678 YP_431880.1 COG0816 YP_431881.1 COG2065 YP_431882.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_431883.1 COG0044 YP_431884.1 DNA uptake protein and related DNA-binding protein; COG1555 YP_431885.1 COG0776 YP_431890.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_431891.1 COG1281 YP_431892.1 COG1188 YP_431893.1 COG1011 YP_431894.1 TIGRFAMsMatches:TIGR01331 YP_431896.1 TIGRFAMsMatches:TIGR00577 YP_431897.1 COG1398 YP_431899.1 COG0742 YP_431900.1 TIGRFAMsMatches:TIGR00064 YP_431901.1 COG2884 YP_431902.1 COG2177 YP_431903.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_431904.1 COG2084 YP_431905.1 COG3622 YP_431906.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_431907.1 COG0745 YP_431908.1 COG0642 YP_431910.1 COG1309 YP_431913.1 TIGRFAMsMatches:TIGR01461 YP_431916.1 COG0582 YP_431917.1 COG4281 YP_431919.1 COG1132 YP_431921.1 COG0210 YP_431923.1 COG1974 YP_431924.1 COG4197 YP_431930.1 COG3335 YP_431931.1 COG3415 YP_431940.1 COG2931 YP_431947.1 COG2003 YP_431949.1 COG3311 YP_431950.1 COG0582 YP_431951.1 COG3526 YP_431952.1 COG0666 YP_431953.1 COG2199 YP_431957.1 COG3220 YP_431961.1 COG3157 YP_431962.1 COG0515 YP_431964.1 TIGRFAMsMatches:TIGR01692 YP_431965.1 COG1024 YP_431966.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_431967.1 COG1960 YP_431968.1 TIGRFAMsMatches:TIGR01722 YP_431970.1 COG1434 YP_431971.1 COG0784 YP_431972.1 TIGRFAMsMatches:TIGR00109 YP_431973.1 COG2863 YP_431974.1 COG2207 YP_431976.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_431977.1 COG1611 YP_431979.1 Required for the synthesis of the thiazole moiety YP_431980.1 COG3437 YP_431981.1 COG3495 YP_431982.1 COG0803 YP_431983.1 COG1136 YP_431984.1 COG0577 YP_431985.1 COG1073 YP_431986.1 COG3706 YP_431995.1 COG0834 YP_431996.1 COG3124 YP_431997.1 COG0784 YP_431998.1 COG1776 YP_431999.1 COG0642 YP_432000.1 COG2738 YP_432009.1 COG1926 YP_432011.1 COG1285 YP_432016.1 TIGRFAMsMatches:TIGR00203 YP_432017.1 COG1271 YP_432019.1 COG0642 YP_432020.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_432023.1 COG4608 YP_432024.1 COG0444 YP_432025.1 COG1173 YP_432026.1 COG0601 YP_432027.1 COG4166 YP_432028.1 COG0421 YP_432029.1 COG0076 YP_432030.1 COG1167 YP_432031.1 COG0834 YP_432032.1 COG0834 YP_432035.1 COG1733 YP_432036.1 COG3256 YP_432037.1 Involved in anaerobic NO protection and iron metabolism YP_432038.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_432046.1 COG1028 YP_432047.1 COG0111 YP_432051.1 COG2872 YP_432052.1 COG1012 YP_432054.1 COG0174 YP_432057.1 COG2343 YP_432060.1 COG2206 YP_432061.1 COG3315 YP_432063.1 COG1737 YP_432065.1 COG5001 YP_432066.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_432067.1 COG4663 YP_432068.1 COG1607 YP_432069.1 COG4664 YP_432070.1 COG4665 YP_432071.1 COG0226 YP_432072.1 COG1196 YP_432073.1 COG4590 YP_432074.1 TIGRFAMsMatches:TIGR00974 YP_432075.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_432076.1 TIGRFAMsMatches:TIGR02135 YP_432077.1 COG2105 YP_432079.1 COG1055 YP_432080.1 COG4757 YP_432081.1 COG0537 YP_432082.1 COG0654 YP_432083.1 COG0834 YP_432084.1 COG2606 YP_432085.1 COG2885 YP_432086.1 COG0668 YP_432087.1 COG3897 YP_432090.1 COG2981 YP_432091.1 COG0784 YP_432092.1 COG0642 YP_432093.1 TIGRFAMsMatches:TIGR02154 YP_432094.1 TIGRFAMsMatches:TIGR01474 YP_432095.1 COG0475 YP_432096.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively YP_432097.1 COG1773 YP_432098.1 COG1251 YP_432099.1 COG0189 YP_432100.1 COG2885 YP_432102.1 TIGRFAMsMatches:TIGR00189 YP_432103.1 COG2220 YP_432104.1 COG4943 YP_432105.1 COG0716 YP_432106.1 COG2947 YP_432107.1 COG3706 YP_432109.1 COG0306 YP_432110.1 COG2404 YP_432111.1 COG5483 YP_432114.1 COG2202 YP_432118.1 COG1032 YP_432119.1 COG1320 YP_432120.1 COG2212 YP_432121.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_432122.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_432123.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_432124.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_432125.1 COG3338 YP_432127.1 COG1028 YP_432128.1 COG0642 YP_432129.1 TIGRFAMsMatches:TIGR00222 YP_432130.1 COG5018 YP_432131.1 COG1515 YP_432134.1 COG1896 YP_432137.1 COG4278 YP_432138.1 COG0834 YP_432141.1 COG2050 YP_432143.1 COG1075 YP_432145.1 COG2207 YP_432146.1 COG3227 YP_432148.1 COG0637 YP_432151.1 Hydrolase of the alpha/beta superfamily; COG1073 YP_432156.1 COG1234 YP_432158.1 COG3851 YP_432160.1 COG3335 YP_432161.1 COG3415 YP_432163.1 COG4977 YP_432164.1 COG0596 YP_432165.1 COG0243 YP_432166.1 COG1733 YP_432167.1 COG1309 YP_432168.1 catalyzes the formation of betaine from betaine aldehyde YP_432169.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_432170.1 COG2113 YP_432171.1 COG4176 YP_432172.1 COG4175 YP_432174.1 COG5473 YP_432175.1 COG2008 YP_432176.1 COG0840 YP_432178.1 COG0642 YP_432179.1 COG3706 YP_432180.1 COG0031 YP_432181.1 Predicted membrane protein; COG4984 YP_432183.1 COG4929 YP_432184.1 COG0477 YP_432187.1 COG3469 YP_432188.1 COG5429 YP_432190.1 TIGRFAMsMatches:TIGR01350 YP_432192.1 COG3184 YP_432194.1 COG2207 YP_432195.1 COG1296 YP_432196.1 COG4392 YP_432199.1 COG1199 YP_432201.1 COG4977 YP_432203.1 COG3204 YP_432204.1 COG0834 YP_432205.1 COG0765 YP_432206.1 COG0765 YP_432207.1 COG1126 YP_432208.1 COG4245 YP_432210.1 COG4248 YP_432213.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_432214.1 COG0419 YP_432218.1 COG1879 YP_432223.1 COG0583 YP_432224.1 COG0697 YP_432225.1 COG4681 YP_432226.1 COG0834 YP_432227.1 COG0462 YP_432228.1 COG3000 YP_432231.1 COG0224 YP_432232.1 produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a catalytic subunit YP_432233.1 COG0711 YP_432234.1 TIGRFAMsMatches:TIGR01260 YP_432235.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit A is part of the membrane proton channel F0 YP_432237.1 COG0355 YP_432238.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the beta chain is a regulatory subunit YP_432239.1 COG4191 YP_432240.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_432248.1 COG2358 YP_432249.1 COG4666 YP_432250.1 COG3517 YP_432251.1 COG2129 YP_432253.1 COG0454 YP_432254.1 COG2804 YP_432259.1 COG0745 YP_432260.1 COG0642 YP_432261.1 COG0477 YP_432263.1 COG2339 YP_432265.1 TIGRFAMsMatches:TIGR01262 YP_432266.1 COG0179 YP_432267.1 COG3508 YP_432268.1 TIGRFAMsMatches:TIGR01263 YP_432269.1 phenylalanine 4-hydroxylase; phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin YP_432270.1 COG1502 YP_432273.1 COG4206 YP_432275.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_432276.1 COG2087 YP_432277.1 COG2038 YP_432278.1 COG0368 YP_432279.1 Fructose-2,6-bisphosphatase; COG0406 YP_432280.1 COG2200 YP_432282.1 COG0642 YP_432284.1 COG4452 YP_432285.1 COG1522 YP_432286.1 TIGRFAMsMatches:TIGR00518 YP_432291.1 COG3484 YP_432292.1 COG4196 YP_432293.1 COG2308 YP_432294.1 COG1305 YP_432295.1 COG2308 YP_432296.1 COG2307 YP_432298.1 COG1842 YP_432299.1 COG3789 YP_432301.1 COG2268 YP_432302.1 COG0419 YP_432306.1 COG0076 YP_432308.1 COG1651 YP_432309.1 COG1309 YP_432310.1 COG5001 YP_432313.1 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzyme COG1249 YP_432314.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_432315.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_432316.1 COG0628 YP_432319.1 COG1145 YP_432320.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_432321.1 COG1012 YP_432323.1 COG1309 YP_432324.1 COG0218 YP_432325.1 COG2863 YP_432326.1 COG0526 YP_432327.1 COG3568 YP_432328.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_432329.1 TIGRFAMsMatches:TIGR00009 YP_432330.1 COG2003 YP_432331.1 TIGRFAMsMatches:TIGR00521 YP_432332.1 COG0756 YP_432333.1 COG1109 YP_432334.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_432336.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_432337.2 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_432338.1 COG4324 YP_432339.1 COG5001 YP_432340.1 TIGRFAMsMatches:TIGR01818 YP_432341.1 COG3852 YP_432343.1 TIGRFAMsMatches:TIGR00653 YP_432344.1 COG1217 YP_432345.1 TIGRFAMsMatches:TIGR01249 YP_432346.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_432348.1 COG3203 YP_432349.1 COG3025 YP_432351.1 COG1391 YP_432352.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_432353.1 TIGRFAMsMatches:TIGR02195 YP_432354.1 TIGRFAMsMatches:TIGR02193 YP_432355.1 COG0463 YP_432356.1 COG0438 YP_432357.1 COG0438 YP_432359.1 COG0463 YP_432360.1 COG1062 YP_432361.1 COG0438 YP_432362.1 TIGRFAMsMatches:TIGR02201 YP_432363.1 COG0438 YP_432364.1 COG1560 YP_432365.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_432366.1 COG0221 YP_432367.1 COG1960 YP_432368.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_432369.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_432370.1 COG0212 YP_432371.1 COG3027 YP_432375.1 COG3079 YP_432376.1 COG0006 YP_432377.1 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; COG0654 YP_432378.1 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; COG0654 YP_432379.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_432380.1 TIGRFAMsMatches:TIGR00945 YP_432381.1 TIGRFAMsMatches:TIGR01410 YP_432382.1 COG1826 YP_432383.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_432384.1 COG0139 YP_432385.1 TIGRFAMsMatches:TIGR01982 YP_432386.1 COG3165 YP_432387.1 COG2226 YP_432391.1 COG1020 YP_432393.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_432394.2 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_432395.1 COG3748 YP_432396.1 Catalyzes the deamination of guanine YP_432397.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_432398.1 COG2351 YP_432399.1 COG3195 YP_432400.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate YP_432401.1 COG0044 YP_432402.1 COG1975 YP_432403.1 COG4631 YP_432404.1 COG4630 YP_432406.1 COG3845 YP_432407.1 COG4603 YP_432408.1 COG1079 YP_432409.1 COG1744 YP_432410.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway. YP_432411.1 COG1309 YP_432413.1 COG0727 YP_432416.1 COG2829 YP_432417.1 COG0265 YP_432419.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_432420.1 COG0789 YP_432421.1 COG0477 YP_432423.1 COG0500 YP_432424.1 Histidyl-tRNA synthetase; COG0124 YP_432425.1 COG2885 YP_432426.1 COG1252 YP_432427.1 COG0834 YP_432429.1 COG4805 YP_432430.1 COG4166 YP_432431.1 COG0601 YP_432432.1 COG1173 YP_432433.1 COG0444 YP_432434.1 COG4608 YP_432435.1 COG2207 YP_432437.1 COG0840 YP_432438.1 COG3979 YP_432439.1 COG3325 YP_432440.1 COG1396 YP_432441.1 COG3550 YP_432447.1 COG0583 YP_432448.1 COG2249 YP_432449.1 COG1309 YP_432451.1 COG3257 YP_432459.1 TIGRFAMsMatches:TIGR01722 YP_432460.1 COG1082 YP_432461.1 COG3962 YP_432462.1 COG0524 YP_432464.1 COG4130 YP_432468.1 COG1879 YP_432469.1 COG1129 YP_432470.1 COG1172 YP_432471.1 COG1879 YP_432472.1 COG0454 YP_432473.1 COG0834 YP_432475.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_432476.1 COG0583 YP_432477.1 COG3263 YP_432479.1 DNA replication protein; COG1484 YP_432480.1 Transposase and inactivated derivatives COG4584 YP_432482.1 COG3415 YP_432483.1 COG3335 YP_432485.1 COG0491 YP_432486.1 COG3531 YP_432488.1 COG1902 YP_432489.1 COG0346 YP_432490.1 COG0583 YP_432491.1 COG3540 YP_432492.1 COG0583 YP_432493.1 COG1741 YP_432496.1 COG0834 YP_432497.1 COG3209 YP_432504.1 COG1132 YP_432505.1 COG1309 YP_432506.1 COG0834 YP_432509.1 COG0845 YP_432510.1 COG0577 YP_432511.1 COG1538 YP_432513.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_432514.1 COG0733 YP_432515.1 COG2867 YP_432516.1 COG2914 YP_432517.1 COG2913 YP_432518.1 COG0735 YP_432519.1 TIGRFAMsMatches:TIGR00634 YP_432520.1 COG0576 YP_432521.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_432522.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_432523.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_432524.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_432525.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_432526.1 COG0782 YP_432527.1 COG1534 YP_432528.1 COG0293 YP_432529.1 COG0465; cell division protein YP_432530.1 TIGRFAMsMatches:TIGR01496 YP_432531.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_432532.1 TIGRFAMsMatches:TIGR00419 YP_432533.1 TIGRFAMsMatches:TIGR00810 YP_432534.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_432535.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_432536.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_432537.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_432538.1 TIGRFAMsMatches:TIGR00431 YP_432539.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_432540.1 COG1185 YP_432541.1 COG1073 YP_432545.1 COG0410 YP_432546.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_432547.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_432548.1 COG0559 YP_432549.1 COG0683 YP_432550.1 TIGRFAMsMatches:TIGR00763 YP_432551.1 COG2606 YP_432552.1 COG3118 YP_432555.1 COG0577 YP_432556.1 COG0577 YP_432557.1 COG1136 YP_432558.1 COG0845 YP_432560.1 COG0277 YP_432561.1 COG1556 YP_432562.1 TIGRFAMsMatches:TIGR00273 YP_432563.1 COG0247 YP_432564.1 COG2186 YP_432565.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_432566.1 TIGRFAMsMatches:TIGR01348 YP_432567.1 COG0790 YP_432572.1 COG0697 YP_432574.1 COG2207 YP_432575.1 COG0702 YP_432576.1 COG0583 YP_432579.1 COG2153 YP_432580.1 COG0384 YP_432582.1 COG1686 YP_432586.1 COG1653 YP_432587.1 COG1175 YP_432588.1 COG0395 YP_432589.1 COG3839 YP_432590.1 COG0246 YP_432591.1 COG2207 YP_432593.1 COG1929 YP_432594.1 COG1182 YP_432595.1 COG0583 YP_432596.1 COG0583 YP_432600.1 COG0523 YP_432601.1 COG2207 YP_432602.1 COG1629 YP_432603.1 COG3553 YP_432605.1 TIGRFAMsMatches:TIGR01068 YP_432606.1 COG0840 YP_432607.1 COG3791 YP_432609.1 COG3706 YP_432612.1 COG1409 YP_432618.1 COG3293 YP_432620.1 COG0789 YP_432621.1 COG0500 YP_432622.1 COG2944 YP_432624.1 COG3415 YP_432625.1 COG3335 YP_432631.1 COG2924 YP_432632.1 TIGRFAMsMatches:TIGR01084 YP_432634.1 COG0131 YP_432635.1 TIGRFAMsMatches:TIGR01855 YP_432636.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_432637.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_432638.1 COG5488 YP_432639.1 COG2861 YP_432640.1 COG0793 YP_432641.1 COG4942 YP_432642.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_432643.1 COG0607 YP_432644.1 TIGRFAMsMatches:TIGR02181 YP_432645.1 similar to hypothetical 17.7K protein (secB region) from Escherichia coli gi|1128972|gb|AAA83908.1| ORF; putative YP_432646.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_432647.1 COG1764 YP_432648.1 COG0219 YP_432650.1 COG4175 YP_432651.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_432652.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_432654.1 COG0183 YP_432655.1 tRNA nucleotidyltransferase/poly(A) polymerase; COG0617 YP_432656.1 COG3018 YP_432658.1 COG1018 YP_432659.1 COG3213 YP_432661.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_432663.1 COG0834 YP_432666.1 COG1943 YP_432668.1 COG3209 YP_432671.1 COG3209 YP_432674.1 COG0454 YP_432675.1 COG3760 YP_432676.1 COG0108 YP_432678.1 COG0642 YP_432679.1 COG4567 YP_432680.1 COG2313 YP_432681.1 COG0524 YP_432682.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_432683.1 COG4594 YP_432684.1 COG1120 YP_432686.1 COG4773 YP_432687.1 acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase; COG0028 YP_432689.1 COG3011 YP_432692.1 COG2110; similar to the C-terminal domain of histone macroH2A1 YP_432693.1 COG0431 YP_432694.1 COG2318 YP_432696.1 COG2166 YP_432697.1 COG2151 YP_432698.1 COG0316 YP_432699.1 COG0520 YP_432700.1 TIGRFAMsMatches:TIGR01981 YP_432701.1 TIGRFAMsMatches:TIGR01978 YP_432703.1 with SufCD activates cysteine desulfurase SufS YP_432704.1 COG1959 YP_432705.1 COG3085 YP_432708.1 COG1047 YP_432709.1 COG2346 YP_432711.1 COG5001 YP_432713.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_432715.1 COG0642 YP_432718.1 COG2885 YP_432720.1 COG0457 YP_432721.1 COG0642 YP_432722.1 COG0745 YP_432725.1 COG1835 YP_432727.1 TIGRFAMsMatches:TIGR01950 YP_432728.1 COG0431 YP_432730.1 COG2909 YP_432731.1 COG1062 YP_432732.1 COG0627 YP_432733.1 COG3791 YP_432744.1 COG3335 YP_432748.1 COG0845 YP_432749.1 COG0841 YP_432750.1 COG0834 YP_432751.1 COG1653 YP_432752.1 COG1902 YP_432754.1 COG0687 YP_432755.1 COG3842 YP_432756.1 COG1176 YP_432757.1 COG1177 YP_432759.1 COG0834 YP_432761.1 COG1051 YP_432762.1 COG2719 YP_432763.1 COG2718 YP_432764.1 COG2766 YP_432765.1 COG2206 YP_432766.1 COG1764 YP_432770.1 COG0501 YP_432773.1 COG1012 YP_432774.1 COG1748 YP_432775.1 COG1522 YP_432779.1 COG0330 YP_432780.1 COG1030 YP_432782.1 COG4886 YP_432784.1 COG0697 YP_432785.1 COG3012 YP_432786.1 catalyzes the formation of inosine from adenosine YP_432787.1 COG1744 YP_432791.1 N-acetyldiaminobutyrate dehydratase; catalyzes the formation of the osmoprotectant ecotoine from gamma-N-acetyl-alpha,gamma-diaminobutyric acid YP_432792.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_432793.1 COG0454 YP_432794.1 COG3181 YP_432798.1 COG1236 YP_432799.1 catalyzes the formation of thymine and 2-deoxy-alpha-D-ribose 1-phosphate from thymidine YP_432800.1 Catalyzes the formation of PRPP from ATP and ribose 5-phosphate YP_432801.1 COG3706 YP_432802.1 COG1052 YP_432804.1 COG0432 YP_432807.1 Predicted membrane protein; COG1295 YP_432810.1 COG4399 YP_432811.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_432812.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_432813.1 COG5001 YP_432814.1 TIGRFAMsMatches:TIGR00676 YP_432815.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_432816.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_432817.1 COG0500 YP_432818.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_432819.1 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; COG0057 YP_432820.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_432821.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_432822.1 COG2267 YP_432823.1 COG2885 YP_432824.1 COG0784 YP_432831.1 COG1408 YP_432834.1 COG2304 YP_432835.1 COG4850 YP_432836.1 COG3122 YP_432837.1 COG1878 YP_432838.1 COG0500 YP_432839.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_432842.1 COG3179 YP_432843.1 COG0154 YP_432844.1 COG0583 YP_432845.1 COG0657 YP_432847.1 COG3488 YP_432853.1 COG0346 YP_432854.1 COG2345 YP_432855.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_432856.1 COG2234 YP_432857.1 COG0782 YP_432859.1 COG2013 YP_432863.1 COG2153 YP_432865.1 COG2013 YP_432866.1 COG2013 YP_432867.1 COG2013 YP_432868.1 COG4783 YP_432871.1 COG2080 YP_432872.1 COG1529 YP_432873.1 Xanthine and CO dehydrogenase maturation factor, XdhC/CoxF family; COG1975 YP_432874.1 COG1279 YP_432875.2 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_432876.1 COG0326 YP_432878.1 COG2930 YP_432879.1 COG3000 YP_432886.1 COG2077 YP_432887.1 COG0400 YP_432888.1 COG0454 YP_432889.1 COG0390 YP_432890.1 COG3842 YP_432891.1 COG0438 YP_432892.1 COG3840 YP_432893.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_432894.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_432896.1 COG1670 YP_432897.1 COG0510 YP_432900.1 COG4191 YP_432901.1 COG2200 YP_432902.1 COG0625 YP_432906.1 COG0730 YP_432907.1 COG0583 YP_432908.1 COG4566 YP_432911.1 COG0515 YP_432913.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_432914.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_432915.1 COG1396 YP_432916.1 COG1840 YP_432917.1 COG0642 YP_432918.1 COG0745 YP_432919.1 COG3181 YP_432921.1 COG3333 YP_432922.1 COG2303 YP_432923.1 COG0642 YP_432924.1 COG2197 YP_432925.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_432926.1 COG0277 YP_432927.1 COG0179 YP_432928.1 COG0840 YP_432930.1 COG0583 YP_432931.1 COG2128 YP_432932.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_432933.1 COG1846 YP_432934.1 TIGRFAMsMatches:TIGR01536 YP_432935.1 COG1181 YP_432936.1 COG1363 YP_432937.1 COG0834 YP_432938.1 COG1179 YP_432940.1 COG2201 YP_432941.1 COG3706 YP_432943.1 COG0661 YP_432945.1 COG2091 YP_432946.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_432947.1 COG0584 YP_432951.1 COG3325 YP_432952.1 COG1942 YP_432953.1 COG0697 YP_432954.1 COG1167 YP_432956.1 COG0346 YP_432957.1 COG1304 YP_432959.1 COG2030 YP_432961.1 COG0628 YP_432962.1 COG1960 YP_432965.1 COG3209 YP_432967.1 COG1757 YP_432968.1 COG1404 YP_432969.1 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain; COG4650 YP_432971.1 COG3431 YP_432973.1 COG0583 YP_432974.1 COG2095 YP_432976.1 COG0735 YP_432977.1 COG0139 YP_432978.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_432979.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_432980.1 COG1734 YP_432981.1 COG0739 YP_432982.1 TIGRFAMsMatches:TIGR02063 YP_432983.1 COG0566 YP_432984.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_432985.1 TIGRFAMsMatches:TIGR00165 YP_432986.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_432987.1 unwinds double stranded DNA YP_432988.1 TIGRFAMsMatches:TIGR00492 YP_432989.1 dTDP-4-dehydrorhamnose reductase; COG1091 YP_432990.1 COG0664 YP_432991.1 COG0635 YP_432992.1 COG0204 YP_432993.1 COG0834 YP_432994.1 COG0834 YP_432995.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_432996.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_432997.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_432998.1 COG0462 YP_432999.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_433000.1 TIGRFAMsMatches:TIGR00548 YP_433001.1 COG0457 YP_433003.2 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_433004.1 TIGRFAMsMatches:TIGR00019 YP_433005.1 COG2890 YP_433006.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_433007.1 COG0415 YP_433008.1 COG4067 YP_433009.1 COG1875 YP_433010.1 COG1309 YP_433011.1 COG0517 YP_433013.1 TIGRFAMsMatches:TIGR01215 YP_433014.1 TIGRFAMsMatches:TIGR01968 YP_433015.1 blocks the formation of polar Z-ring septums YP_433016.1 COG0671 YP_433017.1 COG0438 YP_433018.1 COG0667 YP_433019.1 COG3243 YP_433021.1 COG0840 YP_433023.1 COG0427 YP_433024.1 COG1047 YP_433025.1 COG0204 YP_433026.1 COG3176 YP_433027.1 COG0745 YP_433028.1 COG0642 YP_433029.1 COG1740 YP_433031.1 COG3842 YP_433032.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_433033.1 Ornithine/acetylornithine aminotransferase; COG4992 YP_433034.1 COG0278 YP_433037.1 COG0531 YP_433038.1 COG4536 YP_433039.1 COG4137 YP_433040.1 TIGRFAMsMatches:TIGR00959 YP_433041.1 TIGRFAMsMatches:TIGR00002 YP_433042.1 TIGRFAMsMatches:TIGR02273 YP_433043.1 TIGRFAMsMatches:TIGR00088 YP_433044.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_433045.1 TIGRFAMsMatches:TIGR02225 YP_433046.1 COG1651 YP_433047.1 COG0436 YP_433048.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_433049.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_433050.1 TIGRFAMsMatches:TIGR00644 YP_433051.1 TIGRFAMsMatches:TIGR00020 YP_433052.1 TIGRFAMsMatches:TIGR00499 YP_433053.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_433054.1 COG1639 YP_433055.1 COG0354 YP_433057.1 COG2938 YP_433058.1 catalyzes the formation of oxaloacetate from L-aspartate YP_433059.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_433060.1 Negative regulator of sigma E activity; COG3073 YP_433061.1 Negative regulator of sigma E activity; COG3026 YP_433062.1 Positive regulator of sigma E activity; COG3086 YP_433063.1 Trypsin-like serine protease, typically periplasmic, contain C-terminal PDZ domain; COG0265 YP_433064.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_433065.1 TIGRFAMsMatches:TIGR02227 YP_433067.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_433068.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_433069.1 TIGRFAMsMatches:TIGR00613 YP_433070.1 COG0642 YP_433071.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_433072.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_433073.1 Guanosine polyphosphate pyrophosphohydrolase/synthetase; COG0317 YP_433074.1 COG1694 YP_433076.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_433077.1 COG1639 YP_433078.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_433079.1 putative molecular chaperone; COG1214 YP_433080.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_433082.1 COG0500 YP_433083.1 COG0697 YP_433084.1 COG3038 YP_433085.1 COG2353 YP_433087.1 TIGRFAMsMatches:TIGR02121 YP_433088.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain YP_433089.1 COG2207 YP_433092.1 COG3735 YP_433093.1 COG0583 YP_433094.1 COG4608 YP_433095.1 COG0444 YP_433096.1 COG1173 YP_433097.1 COG0601 YP_433098.1 COG0747 YP_433100.1 Zn-dependent protease with chaperone function COG0501 YP_433103.1 TIGRFAMsMatches:TIGR00441 YP_433104.1 catalyzes the formation of fumarate from aspartate YP_433105.1 COG1444 YP_433107.1 COG0235 YP_433108.1 COG1791 YP_433109.1 TIGRFAMsMatches:TIGR01691 YP_433111.1 COG0642 YP_433112.1 COG0745 YP_433113.1 COG3868 YP_433114.1 COG2207 YP_433115.1 COG1012 YP_433117.1 COG2804 YP_433118.1 COG3308 YP_433119.1 COG0655 YP_433120.1 TIGRFAMsMatches:TIGR00014 YP_433122.1 COG0526 YP_433123.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_433124.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_433125.1 COG0037 YP_433127.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_433128.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_433129.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_433131.1 COG2919 YP_433132.1 TIGRFAMsMatches:TIGR00453 YP_433133.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_433134.1 COG0585 YP_433135.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_433136.1 TIGRFAMsMatches:TIGR00080 YP_433137.1 COG2035 YP_433138.1 COG0739 YP_433139.1 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); COG0568 YP_433141.1 Retron-type reverse transcriptase; COG3344 YP_433144.1 COG0596 YP_433146.1 COG1167 YP_433147.1 COG3467 YP_433149.1 TIGRFAMsMatches:TIGR01083 YP_433150.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_433151.1 COG4659 YP_433152.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_433153.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_433154.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_433155.1 COG4657 YP_433157.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_433159.1 COG0489 YP_433160.2 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_433161.1 COG0235 YP_433162.1 COG3068 YP_433163.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_433165.1 TIGRFAMsMatches:TIGR00639 YP_433166.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_433167.1 COG3249 YP_433168.1 COG0558 YP_433169.1 ATPase involved in DNA replication initiation COG0593 YP_433170.1 ATPase involved in chromosome partitioning; COG1192 YP_433171.1 COG3098 YP_433172.1 COG1573 YP_433173.1 COG0204 YP_433174.1 TIGRFAMsMatches:TIGR02258 YP_433176.1 COG5001 YP_433177.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_433178.1 COG3577 YP_433180.2 COG3023 YP_433181.1 COG3725 YP_433182.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_433183.1 COG0840 YP_433184.1 COG2096 YP_433185.1 catalyzes the formation of 2-dehydropantoate from (R)-pantoate YP_433186.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_433188.1 COG2927 YP_433189.1 COG0260 YP_433191.1 COG0795 YP_433192.1 COG0795 YP_433193.1 COG0840 YP_433194.1 COG0834 YP_433195.1 COG0683 YP_433196.1 COG0693 YP_433197.1 COG4321 YP_433198.1 COG1233 YP_433199.1 COG3647 YP_433200.1 microsomal dipeptidase-like protein; COG2355 YP_433202.1 COG0840 YP_433203.1 COG4977 YP_433205.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_433206.1 Arginine/ornithine N-succinyltransferase beta subunit COG3138 YP_433207.1 Arginine/ornithine N-succinyltransferase beta subunit COG3138 YP_433208.1 NAD-dependent aldehyde dehydrogenase; COG1012 YP_433209.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_433210.1 COG0515 YP_433211.1 COG0631 YP_433212.1 COG1716 YP_433213.1 COG2373 YP_433214.1 TIGRFAMsMatches:TIGR02073 YP_433216.1 COG1896 YP_433219.1 COG0845 YP_433220.1 COG1131 YP_433221.1 COG0842 YP_433222.1 COG2606 YP_433226.1 COG2110; similar to the C-terminal domain of histone macroH2A1 YP_433227.1 COG3209 YP_433234.1 COG0596 YP_433235.1 COG4221 YP_433236.1 Malate/lactate dehydrogenase; COG0039 YP_433238.1 COG2234 YP_433239.1 COG3961 YP_433243.1 COG0393 YP_433244.1 COG0393 YP_433246.1 COG1280 YP_433249.1 thermonuclease; COG1525 YP_433252.1 COG0454 YP_433260.1 COG0687 YP_433261.1 COG5001 YP_433262.1 COG1611 YP_433263.1 COG0697 YP_433264.1 COG2207 YP_433265.1 Superfamily I DNA and RNA helicase; COG0210 YP_433266.1 COG0583 YP_433268.1 COG0251 YP_433269.1 COG3181 YP_433270.1 COG5001 YP_433272.1 COG0266 YP_433273.1 COG0834 YP_433274.1 COG0834 YP_433279.1 COG2378 YP_433280.1 COG0346 YP_433281.1 COG3575 YP_433284.1 COG1028 YP_433286.1 COG3208 YP_433287.1 COG1028 YP_433288.1 COG1020 YP_433289.1 COG1020 YP_433290.1 COG1020 YP_433292.1 COG1296 YP_433293.1 COG4392 YP_433295.1 COG0388 YP_433299.1 COG0575 YP_433300.1 COG1132 YP_433301.1 COG1132 YP_433303.1 COG2818 YP_433304.1 COG0204 YP_433305.1 COG0697 YP_433306.1 COG5460 YP_433307.1 catalyzes the conversion of NADPH to NADH YP_433308.1 COG1639 YP_433310.1 COG0676 YP_433311.1 COG1335 YP_433313.1 COG0477 YP_433314.1 COG0300 YP_433315.1 COG0661 YP_433317.1 COG0564 YP_433319.1 molecular chaperone YP_433324.1 Represses a number of genes involved in the response to DNA damage YP_433325.1 COG2249 YP_433329.1 COG3209 YP_433331.1 COG3209 YP_433336.1 COG3209 YP_433339.1 COG3209 YP_433341.1 COG3209 YP_433343.1 COG3209 YP_433345.1 COG3209 YP_433348.1 COG3209 YP_433350.1 COG3209 YP_433352.1 COG3209 YP_433356.1 Transposase and inactivated derivatives COG3547 YP_433357.1 COG3547 YP_433359.1 COG3155 YP_433360.1 COG3706 YP_433363.1 COG0687 YP_433364.1 COG5001 YP_433365.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_433368.1 COG0477 YP_433369.1 COG0720 YP_433370.1 COG0784 YP_433371.1 COG4642 YP_433374.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_433375.1 COG1026 YP_433376.1 COG1806 YP_433377.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_433378.1 COG0702 YP_433379.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_433380.1 Retron-type reverse transcriptase; COG3344 YP_433382.1 COG3103 YP_433383.1 COG2350 YP_433384.1 Involved in cell division; probably involved in intracellular septation YP_433385.1 COG0613 YP_433386.1 COG1502 YP_433387.1 COG3318 YP_433389.1 COG1530 YP_433390.1 COG0564 YP_433391.1 COG0546 YP_433392.1 COG0616 YP_433393.1 TIGRFAMsMatches:TIGR00172 YP_433395.1 COG1399 YP_433396.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_433397.1 COG0416 YP_433398.1 TIGRFAMsMatches:TIGR00128 YP_433399.1 TIGRFAMsMatches:TIGR01830 YP_433400.1 carries the fatty acid chain in fatty acid biosynthesis YP_433401.1 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; COG0115 YP_433402.1 COG1559 YP_433403.1 TIGRFAMsMatches:TIGR00041 YP_433404.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_433405.1 COG4445 YP_433406.1 TIGRFAMsMatches:TIGR01854 YP_433407.1 COG0652 YP_433408.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_433409.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_433410.1 COG0190 YP_433412.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_433413.1 TIGRFAMsMatches:TIGR00493 YP_433414.1 binds and unfolds substrates as part of the ClpXP protease YP_433416.1 TIGRFAMsMatches:TIGR00763 YP_433417.1 COG0776 YP_433418.1 COG0760 YP_433419.1 COG3271 YP_433421.1 COG2067 YP_433423.1 COG0726 YP_433424.1 COG2214 YP_433427.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_433430.1 COG1012 YP_433431.1 acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase; catalyzes the condensation of two pyruvates to form acetolactate, implicated in pH homeostasis via the acetoin-2,3-butanediol pathway or in valine biosynthesis YP_433432.1 COG5002 YP_433435.1 COG3501 YP_433437.1 COG0793 YP_433438.1 COG1250 YP_433439.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_433441.1 ATPase involved in DNA repair; COG0419 YP_433442.1 COG2137 YP_433443.1 COG4623 YP_433444.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_433446.1 COG3323 YP_433447.1 COG1051 YP_433448.1 COG0494 YP_433449.1 COG0663 YP_433450.1 COG3313 YP_433451.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_433453.1 COG0587 YP_433454.1 COG0389 YP_433456.1 COG0454 YP_433457.1 Secreted/periplasmic Zn-dependent peptidase, insulinase-like COG1025 YP_433459.1 COG0687 YP_433460.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_433461.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_433462.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_433463.1 COG0834 YP_433464.1 COG0826 YP_433465.1 COG0826 YP_433466.1 COG3154 YP_433467.1 COG1280 YP_433469.1 COG0841 YP_433470.1 COG0845 YP_433471.1 COG0729 YP_433472.1 COG2911 YP_433475.1 COG1853 YP_433476.1 COG2813 YP_433477.1 COG0564 YP_433479.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_433480.1 COG5615 YP_433481.1 COG0500 YP_433482.1 COG1682 YP_433483.1 COG1134 YP_433484.1 COG0463 YP_433485.1 COG0451 YP_433486.1 COG0463 YP_433487.1 COG1216 YP_433488.1 COG0500 YP_433489.1 COG0500 YP_433490.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_433491.1 COG3706 YP_433492.1 COG2908 YP_433494.1 COG0225 YP_433498.1 COG1309 YP_433505.1 COG2110; similar to the C-terminal domain of histone macroH2A1 YP_433511.1 COG0662 YP_433515.1 COG0500 YP_433516.1 COG1959 YP_433517.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_433518.1 COG2836 YP_433519.1 TIGRFAMsMatches:TIGR00847 YP_433520.1 TIGRFAMsMatches:TIGR01511 YP_433521.1 COG3198 YP_433522.1 COG0348 YP_433523.1 TIGRFAMsMatches:TIGR00782 YP_433524.1 Cbb3-type cytochrome oxidase, subunit 3; COG4736 YP_433525.1 TIGRFAMsMatches:TIGR00781 YP_433526.1 CcoN; FixN YP_433527.1 COG3571 YP_433528.1 COG2933 YP_433530.1 COG0425 YP_433531.1 COG0697 YP_433532.1 COG4232 YP_433533.1 COG3101 YP_433534.1 COG4268 YP_433535.1 COG1401 YP_433537.1 COG3101 YP_433539.1 Superfamily II DNA and RNA helicase; COG0513 YP_433540.1 COG0111 YP_433544.1 putative metalloprotease YP_433546.1 COG0583 YP_433547.1 COG2367 YP_433549.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_433550.1 COG0229 YP_433551.1 COG2818 YP_433552.1 COG0386 YP_433553.1 COG1846 YP_433554.1 COG0642 YP_433556.1 COG2062 YP_433557.1 COG1744 YP_433558.1 COG3845 YP_433559.1 COG4603 YP_433560.1 COG1079 YP_433561.1 COG0524 YP_433562.1 COG1957 YP_433563.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_433571.1 TIGRFAMsMatches:TIGR01346 YP_433572.1 COG0583 YP_433573.1 COG0664 YP_433576.1 COG2114; some protein contain HAMP domain YP_433577.1 COG0454 YP_433578.1 COG2850 YP_433579.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_433580.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_433581.1 TIGRFAMsMatches:TIGR00420 YP_433582.1 COG0494 YP_433583.1 COG1187 YP_433584.1 TIGRFAMsMatches:TIGR00183 YP_433585.1 COG1278 YP_433586.2 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_433587.1 COG0542 YP_433588.1 TIGRFAMsMatches:TIGR00008 YP_433590.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_433591.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_433592.1 TIGRFAMsMatches:TIGR01292 YP_433593.1 COG0714 YP_433594.1 COG0388 YP_433595.1 COG2957 YP_433598.1 COG4591 YP_433599.1 COG1136 YP_433600.1 TIGRFAMsMatches:TIGR00874 YP_433601.1 COG0042 YP_433602.1 COG3293 YP_433603.1 COG3293 YP_433609.1 COG0834 YP_433614.1 COG2199 YP_433615.1 COG3812 YP_433616.1 TIGRFAMsMatches:TIGR00493 YP_433618.1 COG1555 YP_433622.1 COG1596 YP_433623.1 COG3206 YP_433624.1 TIGRFAMsMatches:TIGR01536 YP_433625.1 COG0500 YP_433627.1 COG2192 YP_433630.1 COG0438 YP_433631.1 COG0463 YP_433632.1 COG2227 YP_433633.1 COG0438 YP_433634.1 TIGRFAMsMatches:TIGR01536 YP_433635.1 TIGRFAMsMatches:TIGR01536 YP_433636.1 COG0438 YP_433637.1 COG0472 YP_433638.1 COG0451 YP_433639.1 COG0332 YP_433640.1 COG0472 YP_433641.1 COG1086 YP_433642.1 TIGRFAMsMatches:TIGR01181 YP_433643.1 TIGRFAMsMatches:TIGR01207 YP_433644.1 TIGRFAMsMatches:TIGR01221 YP_433645.1 TIGRFAMsMatches:TIGR01214 YP_433646.1 COG1216 YP_433647.1 TIGRFAMsMatches:TIGR01479 YP_433648.1 COG4531 YP_433649.1 COG3215 YP_433650.1 COG0084 YP_433651.1 COG0596 YP_433653.1 COG1752 YP_433654.1 involved in methylation of ribosomal protein L3 YP_433655.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_433656.1 COG0477 YP_433657.1 COG1220 YP_433658.1 COG3243 YP_433659.1 COG0583 YP_433661.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_433662.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_433663.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_433664.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_433666.1 TIGRFAMsMatches:TIGR00071 YP_433667.1 COG0135 YP_433668.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_433669.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_433670.1 TIGRFAMsMatches:TIGR00515 YP_433671.1 COG0285 YP_433672.1 uncharacterized protein conserved in bacteria COG3147 YP_433673.1 COG1286 YP_433674.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_433675.1 TIGRFAMsMatches:TIGR01325 YP_433677.1 DNA segregation ATPase FtsK/SpoIIIE and related protein; COG1674 YP_433678.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_433679.1 COG2256 YP_433680.1 COG0239 YP_433681.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_433682.1 COG0007 YP_433684.1 TIGRFAMsMatches:TIGR02142 YP_433685.1 TIGRFAMsMatches:TIGR02141 YP_433686.1 TIGRFAMsMatches:TIGR01256 YP_433688.1 COG2005 YP_433689.1 COG3456 YP_433690.1 COG0840 YP_433691.1 COG2206 YP_433694.1 COG0745 YP_433697.1 COG2931 YP_433698.1 COG1609 YP_433699.1 COG1879 YP_433700.1 COG1129 YP_433701.1 COG1172 YP_433702.1 COG1063 YP_433703.1 COG1070 YP_433704.1 TIGRFAMsMatches:TIGR00874 YP_433706.1 COG1858 YP_433708.1 COG4935 YP_433709.1 COG3227 YP_433710.1 COG0633 YP_433711.1 COG0583 YP_433712.1 COG0697 YP_433713.1 COG1522 YP_433717.1 DNA modification methylase; COG0863 YP_433719.1 COG1033 YP_433723.1 COG0778 YP_433724.1 COG1090 YP_433725.1 COG1024 YP_433726.1 COG3396 YP_433727.1 flavoprotein; COG0644 YP_433728.1 COG0318 YP_433730.1 COG0491 YP_433731.1 COG0451 YP_433734.1 COG0443 YP_433736.1 COG1653 YP_433737.1 COG0659 YP_433738.1 COG0589 YP_433739.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_433743.1 COG0596 YP_433744.1 COG0623 YP_433746.1 COG4172 YP_433747.1 COG4239 YP_433748.1 COG4174 YP_433749.1 COG4166 YP_433750.1 COG1639 YP_433751.1 COG0741 YP_433752.1 COG0491 YP_433753.1 COG0500 YP_433754.1 COG0328 YP_433755.1 TIGRFAMsMatches:TIGR01406 YP_433756.1 involved in regulation of intracellular pH under alkaline conditions YP_433757.1 COG0840 YP_433758.1 COG0841 YP_433759.1 COG3255 YP_433760.1 SohB; periplasmic protein; member of the peptidase S49 family YP_433761.1 COG0604 YP_433762.1 COG4651 YP_433763.1 COG3749 YP_433764.1 COG0155 YP_433768.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_433769.1 COG0694 YP_433770.1 COG0547 YP_433771.1 COG2920 YP_433772.1 COG2168 YP_433773.1 COG2923 YP_433774.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_433775.1 COG0670 YP_433777.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_433778.1 COG0673 YP_433779.1 COG2205 YP_433780.1 COG0168 YP_433783.1 COG0642 YP_433784.1 COG0784 YP_433785.1 COG5001 YP_433786.1 COG4771 YP_433787.1 COG1028 YP_433789.1 Citrate synthase; COG0372 YP_433790.1 acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase; COG0028 YP_433791.1 COG3293 YP_433796.1 COG0834 YP_433797.1 COG0317 YP_433798.1 COG2801 YP_433799.1 COG2801 YP_433800.1 COG2963 YP_433802.1 COG2931 YP_433805.1 COG0840 YP_433807.1 COG1477 YP_433814.1 COG0526 YP_433819.1 COG1729 YP_433820.1 COG0457 YP_433822.1 COG2951 YP_433825.1 COG1189 YP_433826.1 COG0456 YP_433827.1 COG0189 YP_433828.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_433829.1 COG0718 YP_433830.1 TIGRFAMsMatches:TIGR00615 YP_433831.1 TIGRFAMsMatches:TIGR01388 YP_433832.1 COG3100 YP_433833.1 COG2983 YP_433835.1 COG2304 YP_433836.1 COG0121 YP_433837.1 TIGRFAMsMatches:TIGR01139 YP_433838.1 COG0714 YP_433839.1 COG3825 YP_433841.1 COG0457 YP_433842.1 COG1729 YP_433843.1 COG0457 YP_433845.1 COG0811 YP_433847.1 similar to adventurous gliding motility protein S (AglS); COG0848 YP_433849.1 COG2161 YP_433856.1 COG2030 YP_433857.1 COG2267 YP_433860.1 activates fatty acids by binding to coenzyme A; involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids YP_433862.1 TIGRFAMsMatches:TIGR01967 YP_433863.1 catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_433864.1 COG2853 YP_433865.1 COG1752 YP_433866.1 COG3267 YP_433868.1 helicase involved in DNA repair and perhaps also replication YP_433869.1 COG2909 YP_433870.1 COG0730 YP_433871.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_433872.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_433875.1 catalyzes the formation of serine from phosphoserine; also has phosphoserine:homoserine phosphotransferase activity YP_433876.1 TIGRFAMsMatches:TIGR00553 YP_433881.1 COG1721 YP_433882.1 COG1305 YP_433883.1 ATPase involved in DNA replication; COG0470 YP_433885.1 COG0705; similar to Drosophila rhomboid YP_433886.2 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_433889.1 COG0004 YP_433890.1 COG1309 YP_433891.1 COG1376 YP_433892.1 COG1472 YP_433893.1 COG0668 YP_433894.1 Catalyzes the phosphorolytic cleavage of 6-oxopurine nucleosides YP_433896.1 TIGRFAMsMatches:TIGR00580 YP_433897.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_433898.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_433899.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_433900.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_433901.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_433902.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_433903.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_433904.1 COG1477 YP_433905.1 COG2991 YP_433907.1 catalyzes the conversion of NADPH to NADH YP_433908.1 COG0584 YP_433909.1 COG2876 YP_433910.1 COG3216 YP_433911.1 TIGRFAMsMatches:TIGR00361 YP_433912.1 COG0811 YP_433913.1 COG0848 YP_433914.1 TIGRFAMsMatches:TIGR02203 YP_433915.1 TIGRFAMsMatches:TIGR00682 YP_433916.1 COG2835 YP_433917.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_433918.1 COG0394 YP_433919.1 TIGRFAMsMatches:TIGR00179 YP_433920.1 COG1802 YP_433921.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_433922.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_433923.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_433924.1 COG0677 YP_433925.1 COG2148 YP_433926.1 COG1596 YP_433927.1 COG3206 YP_433928.1 ATPase involved in chromosome partitioning; COG0489 YP_433930.1 COG0726 YP_433933.1 COG1020 YP_433934.1 COG0438 YP_433935.1 COG3919 YP_433936.1 COG0394 YP_433937.1 COG3307 YP_433938.1 COG0438 YP_433939.1 COG2244 YP_433941.1 uncharacterized conserved protein; COG2327 YP_433942.1 COG1835 YP_433943.1 COG0438 YP_433944.1 COG1541 YP_433945.1 COG0110 YP_433947.1 COG0438 YP_433948.1 COG0529 YP_433949.1 COG0438 YP_433950.1 COG0726 YP_433953.1 COG0471 YP_433955.1 COG1215 YP_433956.1 COG0399 YP_433957.1 COG0457 YP_433958.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_433959.1 COG0642 YP_433961.1 COG0451 YP_433962.1 COG0204 YP_433965.1 COG3937 YP_433966.1 COG1309 YP_433967.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_433968.1 COG3272 YP_433969.1 COG1078 YP_433970.1 COG2208 YP_433971.1 COG1366 YP_433972.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_433973.1 TIGRFAMsMatches:TIGR00249 YP_433974.1 COG0520 YP_433975.1 COG0517 YP_433977.1 COG1145 YP_433979.1 COG4572 YP_433980.1 COG3816 YP_433982.1 COG1305 YP_433984.1 COG3209 YP_433985.1 COG2931 YP_433986.1 COG2199 YP_433990.1 COG0714 YP_433991.1 COG0631 YP_433992.1 COG0515 YP_433995.1 Periplasmic protease; COG0793 YP_433998.1 COG0441 YP_434000.1 COG1522 YP_434001.1 COG0697 YP_434002.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_434003.1 COG0523 YP_434004.1 COG0834 YP_434005.1 COG0687 YP_434006.1 COG0330 YP_434007.1 COG4615 YP_434010.1 COG2850 YP_434011.1 COG2192 YP_434016.1 COG1203 YP_434019.1 COG3649 YP_434020.1 COG1468 YP_434021.1 TIGRFAMsMatches:TIGR00287 YP_434022.1 COG1343 YP_434027.1 COG0500 YP_434028.1 COG1881 YP_434029.1 COG0412 YP_434030.1 COG2059 YP_434039.1 COG3335 YP_434047.1 COG0477 YP_434048.1 COG1960 YP_434049.1 COG1021 YP_434050.1 COG1804 YP_434051.1 COG1977 YP_434052.1 COG1310 YP_434053.1 COG0476 YP_434054.1 COG0582 YP_434057.1 COG0270 YP_434061.1 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases COG0847 YP_434076.1 COG2197 YP_434081.1 COG4643 YP_434086.1 COG3023 YP_434092.1 COG4220 YP_434093.1 COG5525 YP_434094.1 TIGRFAMsMatches:TIGR01539 YP_434095.1 COG0616 YP_434097.1 COG1523 YP_434104.1 COG0840 YP_434114.1 COG1284 YP_434122.1 COG1879 YP_434123.1 COG0834 YP_434125.1 COG0477 YP_434126.1 COG2207 YP_434127.1 COG1309 YP_434134.1 COG4430 YP_434135.1 COG1670 YP_434136.1 COG1108 YP_434137.1 COG1121 YP_434139.1 COG4531 YP_434140.1 COG2319 YP_434142.1 COG0803 YP_434143.1 COG1108 YP_434144.1 COG0735 YP_434153.1 COG1020 YP_434154.1 COG1032 YP_434155.1 COG1020 YP_434156.1 COG1020 YP_434157.1 COG1020 YP_434158.1 COG1020 YP_434159.1 COG3321 YP_434160.1 COG1020 YP_434161.1 COG3321 YP_434162.1 COG3321 YP_434164.1 COG3597 YP_434166.1 COG2199 YP_434172.1 catalyzes the formation of pyruvate from serine YP_434173.1 COG0583 YP_434174.1 COG3434 YP_434175.1 COG1404 YP_434178.1 COG4539 YP_434179.1 COG2273 YP_434180.1 COG0625 YP_434182.1 COG2227 YP_434185.1 COG1670 YP_434192.1 COG0024 YP_434194.1 unwinds double stranded DNA YP_434195.1 COG3545 YP_434198.1 COG2207 YP_434199.1 COG4188 YP_434204.1 COG3232 YP_434208.1 COG2234 YP_434210.1 COG1538 YP_434211.1 COG0845 YP_434212.1 COG3696 YP_434213.1 COG4454 YP_434215.1 COG2010 YP_434216.1 COG1262 YP_434217.1 COG1051 YP_434218.1 COG4461 YP_434221.1 COG3576 YP_434224.1 COG3391 YP_434226.1 COG5640 YP_434227.1 COG0664 YP_434229.1 COG2847 YP_434233.1 COG2340 YP_434234.1 COG3708 YP_434235.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_434236.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_434242.1 COG5350 YP_434244.1 COG0596 YP_434245.1 COG2207 YP_434247.1 COG0834 YP_434249.1 COG0451 YP_434251.1 COG0477 YP_434252.1 COG0693 YP_434256.1 COG0739 YP_434257.1 COG0583 YP_434259.1 COG2267 YP_434261.1 COG1943 YP_434262.1 COG0546 YP_434264.1 TIGRFAMsMatches:TIGR00383 YP_434265.1 TIGRFAMsMatches:TIGR00126 YP_434266.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_434267.1 TIGRFAMsMatches:TIGR00107 YP_434268.1 COG0583 YP_434270.1 COG0406 YP_434271.1 COG4341 YP_434272.1 COG0560 YP_434273.1 COG0665 YP_434274.1 COG0697 YP_434275.1 catalyzes the degradation of phosphonoacetaldehyde to acetaldehyde and phosphate YP_434276.1 COG0075 YP_434277.1 COG1178 YP_434278.1 COG3842 YP_434279.1 COG1840 YP_434280.1 COG2188 YP_434283.1 COG4973 YP_434286.1 TIGRFAMsMatches:TIGR01312 YP_434287.1 COG2202 YP_434292.1 COG1051 YP_434294.1 COG3488 YP_434296.1 COG0454 YP_434298.1 COG2202 YP_434301.1 COG1073 YP_434305.1 COG1653 YP_434306.1 COG1653 YP_434309.1 COG0583 YP_434310.1 COG2249 YP_434311.1 COG0006 YP_434312.1 COG4608 YP_434313.1 COG0444 YP_434314.1 COG1173 YP_434315.1 COG0601 YP_434316.1 COG4166 YP_434322.1 COG2020 YP_434323.1 COG0156 YP_434324.1 COG3687 YP_434325.1 COG4380 YP_434326.1 COG4259 YP_434327.1 COG1462 YP_434328.1 flavoprotein; COG0644 YP_434330.1 COG4886 YP_434332.1 COG4886 YP_434334.1 COG1398 YP_434335.1 COG1366 YP_434336.1 COG3706 YP_434347.1 COG3791 YP_434350.1 COG1012 YP_434351.1 TIGRFAMsMatches:TIGR00674 YP_434352.1 COG3866 YP_434354.1 COG0665 YP_434355.1 COG3938 YP_434356.1 COG1802 YP_434358.1 COG2207 YP_434363.1 COG2207 YP_434369.1 COG0515 YP_434370.1 COG2207 YP_434371.1 COG1171 YP_434376.1 COG0488 YP_434377.1 COG4675 YP_434378.1 COG4675 YP_434380.1 COG4625 YP_434381.1 COG2931 YP_434382.1 COG2801 YP_434384.1 COG1309 YP_434385.1 COG0625 YP_434389.1 COG0640 YP_434390.1 COG3832 YP_434391.1 COG3852 YP_434393.1 TIGRFAMsMatches:TIGR00198 YP_434398.1 TIGRFAMsMatches:TIGR00178 YP_434399.1 COG0477 YP_434400.1 COG1566 YP_434401.1 COG1846 YP_434403.1 COG5285 YP_434404.1 COG1112 YP_434409.1 COG5343 YP_434410.1 COG1595 YP_434415.1 COG4315 YP_434419.1 COG1309 YP_434420.1 COG2350 YP_434421.1 COG2818 YP_434422.1 COG0583 YP_434423.1 COG0500 YP_434425.1 Type II secretory pathway, component PulD COG1450 YP_434432.1 COG4669 YP_434434.1 COG1317 YP_434435.1 COG3209 YP_434437.1 COG3209 YP_434443.1 COG3335 YP_434444.1 COG4792 YP_434445.1 COG4791 YP_434446.1 COG4794 YP_434447.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response YP_434448.1 COG1886 YP_434451.1 COG1157 YP_434452.1 COG1106 YP_434453.1 COG1943 YP_434454.1 COG4101 YP_434455.1 COG4789 YP_434462.1 COG0457 YP_434468.1 COG3293 YP_434469.1 COG3547 YP_434470.1 Transposase and inactivated derivatives COG3547 YP_434474.1 COG3293 YP_434476.1 COG1653 YP_434477.1 COG1175 YP_434478.1 COG0395 YP_434479.1 COG3839 YP_434480.1 COG1234 YP_434481.1 COG0483 YP_434482.1 COG1609 YP_434485.1 COG0457 YP_434488.1 COG4315 YP_434490.1 COG2375 YP_434491.1 COG1846 YP_434492.1 COG0834 YP_434493.1 COG2801 YP_434495.1 COG0160 YP_434496.1 COG0714 YP_434497.1 COG3831 YP_434500.1 COG3791 YP_434502.1 COG0583 YP_434503.1 COG0625 YP_434504.1 COG3576 YP_434506.1 COG2916 YP_434511.1 COG1167 YP_434512.1 COG1182 YP_434513.1 COG0526 YP_434514.1 COG4232 YP_434516.1 COG2207 YP_434517.1 COG1742 YP_434518.1 COG1309 YP_434519.1 COG2220 YP_434520.1 COG0702 YP_434527.1 COG0583 YP_434529.1 COG2823 YP_434530.1 COG1305 YP_434531.1 COG1305 YP_434534.1 COG1776 YP_434535.1 COG3706 YP_434541.1 COG3062 YP_434542.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_434543.1 COG3043 YP_434544.1 COG3005 YP_434545.1 COG0840 YP_434546.1 COG2114; some protein contain HAMP domain YP_434551.1 COG3210 YP_434553.1 COG4995 YP_434554.1 COG2831 YP_434559.1 COG4314 YP_434560.1 COG1277 YP_434561.1 COG1131 YP_434562.1 COG3420 YP_434563.1 reduces nitrous oxide to nitrogen YP_434564.1 COG3901 YP_434565.1 COG1432 YP_434568.1 COG1733 YP_434569.1 COG0596 YP_434570.1 COG3865 YP_434575.1 COG3293 YP_434579.1 COG0824 YP_434580.1 COG0789 YP_434581.1 COG2249 YP_434582.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_434583.1 COG1250 YP_434584.1 COG0705; similar to Drosophila rhomboid YP_434585.1 COG2148 YP_434587.1 COG1404 YP_434588.1 COG0464 YP_434590.1 COG5017 YP_434592.1 COG0438 YP_434594.1 COG0438 YP_434599.1 COG0489 YP_434600.1 COG3206 YP_434601.1 COG1596 YP_434602.1 COG0760 YP_434611.1 COG1250 YP_434613.1 COG3208 YP_434614.1 COG2850 YP_434615.1 COG3321 YP_434616.1 COG1020 YP_434617.1 COG1020 YP_434618.1 COG4615 YP_434619.1 COG3321 YP_434620.1 COG1020 YP_434621.1 COG0331 YP_434622.1 COG1020 YP_434623.1 COG1020 YP_434624.1 COG1960 YP_434625.1 COG0236 YP_434627.1 COG0614 YP_434628.1 COG0609 YP_434629.1 COG4779 YP_434630.1 COG1120 YP_434631.1 COG4759 YP_434632.1 COG1629 YP_434634.1 COG0840 YP_434635.1 COG1201 YP_434636.1 COG0840 YP_434641.1 COG4637 YP_434642.1 COG0515 YP_434643.1 COG3311 YP_434645.1 COG0834 YP_434646.1 COG0834 YP_434654.1 COG0477 YP_434655.1 COG3321 YP_434656.1 COG3321 YP_434657.1 COG1335 YP_434658.1 COG2907 YP_434659.1 COG0331 YP_434660.1 COG3321 YP_434661.1 COG3321 YP_434662.1 COG3321 YP_434665.1 COG0604 YP_434666.1 COG1733 YP_434671.1 COG3263 YP_434672.1 COG0076 YP_434673.1 COG2199 YP_434674.1 COG2199 YP_434675.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_434676.1 COG4886 YP_434682.1 COG0583 YP_434684.1 COG0845 YP_434685.1 COG0841 YP_434686.1 COG2032 YP_434689.1 COG0834 YP_434691.1 COG0834 YP_434692.1 COG0348 YP_434693.1 COG1167 YP_434694.1 COG2301 YP_434695.1 COG0454 YP_434696.1 COG1902 YP_434697.1 COG1959 YP_434699.1 COG3501 YP_434701.1 COG3209 YP_434703.1 COG1309 YP_434704.1 COG2220 YP_434707.1 COG4663 YP_434708.1 COG4665 YP_434709.1 COG4664 YP_434710.1 COG3265 YP_434711.1 COG1609 YP_434713.1 COG1479 YP_434714.1 COG4232 YP_434715.1 COG0526 YP_434731.1 COG2207 YP_434738.1 COG0526 YP_434740.1 COG1629 YP_434741.1 COG0834 YP_434751.1 COG2132 YP_434752.1 COG1846 YP_434753.1 COG0778 YP_434754.1 COG5002 YP_434755.1 COG0834 YP_434756.1 COG0834 YP_434757.1 COG3047 YP_434758.1 COG2885 YP_434761.1 COG4307 YP_434763.1 COG3120 YP_434764.1 COG0318 YP_434765.1 COG2124 YP_434766.1 COG2124 YP_434767.1 COG3321 YP_434768.1 COG2192 YP_434769.1 COG1696 YP_434771.1 COG0834 YP_434773.1 COG0551 YP_434777.1 COG0642 YP_434778.1 COG0745 YP_434783.1 COG0491 YP_434784.1 COG0583 YP_434785.1 COG5006 YP_434786.1 COG0535 YP_434787.1 COG0010 YP_434788.1 COG0840 YP_434789.1 COG1360 YP_434792.1 COG0553 YP_434793.1 COG3791 YP_434795.1 COG1680 YP_434796.1 TIGRFAMsMatches:TIGR00754 YP_434797.1 COG0730 YP_434798.1 COG0784 YP_434806.1 TIGRFAMsMatches:TIGR00652 YP_434809.1 COG2984 YP_434810.1 COG2984 YP_434811.1 COG0642 YP_434812.1 COG5001 YP_434813.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_434814.1 COG0443 YP_434815.1 COG0443 YP_434819.1 COG5453 YP_434823.1 COG0500 YP_434827.1 COG4247 YP_434828.1 COG4325 YP_434830.1 COG1409 YP_434833.1 COG2119 YP_434834.1 COG4305 YP_434839.1 COG4412 YP_434843.1 COG0697 YP_434844.1 COG1896 YP_434845.1 COG1230 YP_434846.1 TIGRFAMsMatches:TIGR02047 YP_434848.1 COG0515 YP_434849.1 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzyme COG0508 YP_434850.1 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit COG0022 YP_434851.1 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit COG1071 YP_434855.1 COG0697 YP_434856.1 COG0031 YP_434857.1 COG0019 YP_434859.1 COG0583 YP_434861.1 COG0530 YP_434862.1 COG3836 YP_434863.1 COG0642 YP_434864.1 COG3437 YP_434865.1 COG2201 YP_434866.1 COG1871 YP_434867.1 COG1352 YP_434868.1 COG0835 YP_434869.1 COG0840 YP_434871.1 COG0643 YP_434872.1 COG1366 YP_434873.1 COG0784 YP_434874.1 COG2200 YP_434875.1 COG0642 YP_434876.1 COG0596 YP_434878.1 COG0189 YP_434881.1 COG2239 YP_434885.1 COG1028 YP_434886.1 COG1733 YP_434904.1 COG3153 YP_434905.1 COG3811 YP_434906.1 COG0840 YP_434910.1 COG0834 YP_434911.1 COG0765 YP_434912.1 COG1126 YP_434913.1 COG2071 YP_434916.1 COG0845 YP_434917.1 COG0841 YP_434928.1 COG3209 YP_434932.1 COG3209 YP_434934.1 COG3209 YP_434937.1 COG3293 YP_434938.1 COG3209 YP_434941.1 COG3209 YP_434942.1 COG0187 YP_434944.1 COG1979 YP_434945.1 COG0841 YP_434946.1 COG0845 YP_434947.1 with FepCDG is involved in the transport of ferric enterobactin YP_434948.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_434949.1 with FepBCG is involved in the transport of ferric enterobactin YP_434950.1 with FepBCD is involved in the transport of ferric enterobactin YP_434951.1 COG1120 YP_434952.1 COG0625 YP_434953.1 COG2259 YP_434954.1 COG0583 YP_434960.1 COG1205 YP_434961.1 COG0553 YP_434962.1 COG1002 YP_434970.1 COG4188 YP_434972.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function YP_434975.1 COG1020 YP_434976.1 COG3251 YP_434977.1 COG2382 YP_434978.1 COG1629 YP_434981.1 COG0494 YP_434982.1 COG0494 YP_434983.1 COG0346 YP_434984.1 COG1335 YP_434985.1 COG0583 YP_434986.1 COG1918 YP_434987.1 COG1918 YP_434988.1 TIGRFAMsMatches:TIGR00437 YP_434990.1 COG3239 YP_434991.1 COG1018 YP_434993.1 COG2236 YP_434998.1 COG2200 YP_434999.1 COG2201 YP_435000.1 COG0643 YP_435001.1 COG0840 YP_435002.1 COG0835 YP_435003.1 COG1352 YP_435004.1 COG0835 YP_435005.1 COG0546 YP_435007.1 COG0486 YP_435010.1 TIGRFAMsMatches:TIGR00528 YP_435011.1 TIGRFAMsMatches:TIGR00720 YP_435012.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_435013.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_435014.1 TIGRFAMsMatches:TIGR00527 YP_435015.1 COG0583 YP_435017.1 COG2200 YP_435019.1 COG0457 YP_435023.1 COG2207 YP_435025.1 COG0488 YP_435026.1 COG0500 YP_435033.1 COG0110 YP_435034.1 COG3832 YP_435045.1 COG1404 YP_435049.1 COG0666 YP_435050.1 COG0583 YP_435052.1 COG0666 YP_435053.1 COG2931 YP_435057.1 COG1280 YP_435059.1 COG0583 YP_435060.1 catalyzes the interconversion of chorismate to prephenate YP_435061.1 COG2730 YP_435068.1 COG1629 YP_435069.1 COG2984 YP_435070.1 COG0642 YP_435071.1 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzyme COG1249 YP_435072.1 COG0454 YP_435074.1 COG3149 YP_435075.1 COG3297 YP_435076.1 COG3156 YP_435077.1 TIGRFAMsMatches:TIGR01711 YP_435078.1 TIGRFAMsMatches:TIGR01707 YP_435079.1 TIGRFAMsMatches:TIGR01708 YP_435080.1 TIGRFAMsMatches:TIGR01710 YP_435081.1 TIGRFAMsMatches:TIGR02120 YP_435082.1 COG2804 YP_435084.1 COG3672 YP_435086.1 COG0789 YP_435088.1 COG1960 YP_435089.1 COG4799 YP_435090.1 COG1024 YP_435091.1 COG4770 YP_435092.1 COG0119 YP_435093.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_435094.1 COG2025 YP_435095.1 COG2086 YP_435097.1 flavoprotein; COG0644 YP_435100.1 COG3344 YP_435102.1 COG3344 YP_435106.1 COG0438 YP_435108.1 COG0398 YP_435110.1 COG2413 YP_435111.1 COG0617 YP_435114.1 COG5622 YP_435117.1 GbpA; plays a role mediating bacterial attachment and colonization of zooplankton and/or intestinal epithelium; in Vibrio cholerae this protein probably binds directly N-acetylglucosamine residues in chitin, glycoproteins and lipids on intestinal epithelial cells YP_435121.1 COG0451 YP_435123.1 COG4704 YP_435125.1 COG0668 YP_435126.1 COG2207 YP_435127.1 COG0667 YP_435128.1 COG0454 YP_435131.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_435132.1 COG4273 YP_435133.1 COG1396 YP_435134.1 COG1115 YP_435141.1 COG2223 YP_435142.1 COG2223 YP_435143.1 COG0515 YP_435144.1 COG0834 YP_435147.1 COG0666 YP_435148.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_435149.1 COG0760 YP_435150.1 TIGRFAMsMatches:TIGR00351 YP_435151.1 TIGRFAMsMatches:TIGR00684 YP_435152.1 TIGRFAMsMatches:TIGR01660 YP_435153.1 TIGRFAMsMatches:TIGR01580 YP_435154.1 COG3850 YP_435157.1 COG0175 YP_435159.1 COG3336 YP_435160.1 COG1999 YP_435161.1 COG2223 YP_435162.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_435164.1 COG0053 YP_435165.1 COG0642 YP_435166.1 COG0784 YP_435167.1 COG3437 YP_435168.1 COG0642 YP_435169.1 COG1639 YP_435170.1 COG0784 YP_435172.1 COG0841 YP_435173.1 COG0845 YP_435176.1 COG5001 YP_435179.1 COG3930 YP_435180.1 COG0388 YP_435181.1 COG2197 YP_435182.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_435183.1 TIGRFAMsMatches:TIGR00560 YP_435185.1 COG3034 YP_435186.1 COG0465 YP_435187.1 COG0071 YP_435192.1 COG3070 YP_435193.1 COG0454 YP_435194.1 COG0607 YP_435195.1 COG4977 YP_435197.1 COG0834 YP_435200.1 COG0834 YP_435202.1 COG3209 YP_435204.1 COG0457 YP_435205.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_435207.1 Flagellar motor switch/type III secretory pathway protein; COG1886 YP_435209.1 COG1749 YP_435210.1 COG1843 YP_435213.1 Flagellar biosynthesis/type III secretory pathway ATPase; COG1157 YP_435214.1 Flagellar biosynthesis/type III secretory pathway protein; COG1317 YP_435216.1 TIGRFAMsMatches:TIGR00206 YP_435217.1 TIGRFAMsMatches:TIGR00205 YP_435218.1 TIGRFAMsMatches:TIGR01395 YP_435219.1 COG1815 YP_435220.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_435221.1 COG2063 YP_435222.1 COG1261 YP_435223.1 COG4786 YP_435224.1 COG4786 YP_435225.1 COG1298 YP_435226.1 COG1377 YP_435227.1 COG1684 YP_435228.1 TIGRFAMsMatches:TIGR01402 YP_435229.1 COG0457 YP_435232.1 COG3335 YP_435233.1 COG3713 YP_435234.1 COG0476 YP_435235.1 COG1185 YP_435237.1 COG0647 YP_435238.1 COG3023 YP_435241.1 COG4637 YP_435243.1 COG5006 YP_435244.1 COG3236 YP_435252.1 COG0288 YP_435253.1 COG0745 YP_435254.1 COG0642 YP_435255.1 COG0793 YP_435259.1 COG0272 YP_435262.1 COG2081 YP_435263.1 COG4943 YP_435264.1 COG0642 YP_435265.1 COG0745 YP_435266.1 COG0841 YP_435267.1 COG0845 YP_435268.1 COG1538 YP_435270.1 COG1397 YP_435277.1 COG0643 YP_435279.1 COG2199 YP_435283.1 COG2340 YP_435284.1 COG0366 YP_435286.1 COG0366 YP_435287.1 COG0477 YP_435288.1 COG5343 YP_435289.1 COG1595 YP_435290.1 COG4315 YP_435295.1 COG0834 YP_435296.1 COG1201 YP_435299.1 COG1696 YP_435300.1 TIGRFAMsMatches:TIGR02018 YP_435301.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_435302.1 TIGRFAMsMatches:TIGR01227 YP_435303.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_435304.1 TIGRFAMsMatches:TIGR01225 YP_435305.1 COG0834 YP_435306.1 COG0834 YP_435307.1 COG0790 YP_435308.1 COG0491 YP_435309.1 COG0640 YP_435310.1 COG3453 YP_435311.1 COG0730 YP_435312.1 COG3227 YP_435313.1 COG0693 YP_435314.1 COG4977 YP_435315.1 COG1397 YP_435316.1 COG3228 YP_435321.1 COG4625 YP_435323.1 COG2130 YP_435324.1 COG0583 YP_435325.1 COG0578 YP_435328.1 COG1234 YP_435332.1 COG3453 YP_435336.1 COG1653 YP_435338.1 COG1670 YP_435341.1 COG1280 YP_435345.1 COG2207 YP_435346.1 COG0342 YP_435349.1 COG0500 YP_435352.1 COG0695 YP_435354.1 COG0477 YP_435355.1 COG2346 YP_435356.1 COG5002 YP_435368.1 COG0784 YP_435369.1 COG5001 YP_435370.1 COG4251 YP_435371.1 COG2936 YP_435372.1 COG4625 YP_435373.1 COG5002 YP_435374.1 COG0515 YP_435376.1 COG0790 YP_435378.1 COG3515 YP_435379.1 COG3516 YP_435380.1 COG3517 YP_435381.1 COG3517 YP_435382.1 COG3518 YP_435383.1 COG3519 YP_435384.1 COG3520 YP_435385.1 COG0542 YP_435386.1 COG1943 YP_435387.1 COG0346 YP_435388.1 COG0583 YP_435389.1 COG1359 YP_435391.1 COG0251 YP_435392.1 COG5380 YP_435393.1 COG1075 YP_435396.1 COG0784 YP_435398.1 COG0784 YP_435399.1 COG0642 YP_435401.1 COG4771 YP_435402.1 COG2200 YP_435403.1 COG4339 YP_435405.1 COG4663 YP_435406.1 COG4665 YP_435407.1 COG4664 YP_435408.1 COG4670 YP_435409.1 acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase; COG0028 YP_435410.1 COG3501 YP_435412.1 COG5351 YP_435414.1 COG0304 YP_435426.1 COG3157 YP_435428.1 COG0631 YP_435429.1 COG3913 YP_435430.1 COG3523 YP_435431.1 COG3455 YP_435432.1 COG3522 YP_435433.1 COG3521 YP_435434.1 COG3456 YP_435435.1 COG0784 YP_435437.1 COG0784 YP_435438.1 COG0642 YP_435439.1 COG3318 YP_435440.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_435441.1 COG0366 YP_435442.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_435443.1 COG2885 YP_435444.1 COG0446 YP_435446.1 COG1396 YP_435449.1 COG5651 YP_435451.1 COG0534 YP_435452.1 COG0583 YP_435453.1 Nucleotidyltransferase/DNA polymerase involved in DNA repair; COG0389 YP_435456.1 COG0840 YP_435460.1 COG0834 YP_435461.1 COG0834 YP_435463.1 COG3791 YP_435464.1 COG1073 YP_435465.1 COG0642 YP_435469.1 COG0745 YP_435470.1 COG3000 YP_435473.1 COG1628 YP_435476.1 COG0454 YP_435478.1 COG0739 YP_435479.1 COG4122 YP_435480.1 COG2072 YP_435481.1 COG0604 YP_435484.1 COG0745 YP_435485.1 COG0642 YP_435486.1 COG0182 YP_435487.1 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline YP_435488.1 Involved in ubiquinone biosynthesis YP_435489.1 COG0546 YP_435490.1 COG1028 YP_435491.1 COG4446 YP_435492.1 COG4235 YP_435493.1 uncharacterized protein involved in biosynthesis of c-type cytochromes COG3088 YP_435494.1 Thiol-disulfide isomerase and thioredoxins COG0526 YP_435495.1 TIGRFAMsMatches:TIGR00353 YP_435496.1 COG2332 YP_435497.1 COG3114 YP_435498.1 COG0755 YP_435499.1 TIGRFAMsMatches:TIGR01190 YP_435500.1 ATP-binding protein; required for proper cytochrome c maturation YP_435502.1 COG2257 YP_435503.1 COG3492 YP_435504.1 COG0783; oxidative damage protectant YP_435506.1 COG3264 YP_435509.1 COG0834 YP_435511.1 COG2823 YP_435513.1 COG2989 YP_435514.1 COG1409 YP_435515.1 COG1597 YP_435518.1 COG1018 YP_435519.1 COG0583 YP_435520.1 COG1670 YP_435533.1 COG0491 YP_435534.1 COG0760 YP_435535.1 COG1132 YP_435536.1 COG2832 YP_435537.1 COG2873 YP_435538.1 COG4548 YP_435539.1 COG3256 YP_435540.1 COG2010 YP_435543.1 COG0714 YP_435544.1 COG2863 YP_435545.1 COG2010 YP_435546.1 COG2010 YP_435547.1 COG3391 YP_435548.1 COG1522 YP_435549.1 COG1522 YP_435550.1 COG1522 YP_435551.1 COG1522 YP_435552.1 COG0535 YP_435553.1 COG2010 YP_435555.1 COG0662 YP_435561.1 COG3335 YP_435562.1 COG1403 YP_435566.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_435567.1 COG0596 YP_435573.1 COG3434 YP_435575.1 COG0084 YP_435578.1 COG5001 YP_435579.1 TIGRFAMsMatches:TIGR00016 YP_435580.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_435581.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_435582.1 COG1520 YP_435583.1 COG2976 YP_435584.1 TIGRFAMsMatches:TIGR00442 YP_435585.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_435586.1 COG1426 YP_435587.1 COG3063 YP_435588.1 COG0820 YP_435589.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_435590.1 COG1104 YP_435591.1 TIGRFAMsMatches:TIGR02010 YP_435592.1 TIGRFAMsMatches:TIGR01172 YP_435593.1 COG0565 YP_435594.1 COG0483 YP_435595.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_435596.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_435597.1 TIGRFAMsMatches:TIGR00739 YP_435598.1 TIGRFAMsMatches:TIGR00430 YP_435599.1 TIGRFAMsMatches:TIGR00113 YP_435601.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes. YP_435602.1 COG1256 YP_435603.1 COG1705 YP_435604.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_435605.1 COG2063 YP_435606.1 makes up the distal portion of the flagellar basal body rod YP_435607.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_435608.1 COG1749 YP_435609.1 COG1843 YP_435610.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_435611.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_435612.1 COG0778 YP_435615.1 COG2114; some protein contain HAMP domain YP_435616.1 COG0477 YP_435617.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_435618.1 COG0842 YP_435619.1 COG1131 YP_435620.1 COG0767 YP_435621.1 COG2206 YP_435624.1 COG1840 YP_435625.1 COG1178 YP_435626.1 COG1022 YP_435628.1 COG2984 YP_435629.1 COG4120 YP_435630.1 COG1101 YP_435631.1 COG3287 YP_435632.1 COG5001 YP_435633.1 COG1171 YP_435634.1 COG2897 YP_435640.1 COG0410 YP_435641.1 COG4674 YP_435642.1 COG4177 YP_435643.1 COG0559 YP_435644.1 COG0683 YP_435645.1 COG0829 YP_435646.1 COG0831 YP_435647.1 COG0832 YP_435648.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_435649.1 COG2371 YP_435650.1 COG0830 YP_435651.1 TIGRFAMsMatches:TIGR00101 YP_435652.1 Hydrogenase/urease accessory protein; COG2370 YP_435655.1 TIGRFAMsMatches:TIGR00558 YP_435658.1 GMP synthase - Glutamine amidotransferase domain; COG0518 YP_435660.1 COG1254 YP_435676.1 COG5614 YP_435678.1 TIGRFAMsMatches:TIGR01554 YP_435679.1 TIGRFAMsMatches:TIGR01543 YP_435680.1 TIGRFAMsMatches:TIGR01537 YP_435681.1 COG4626 YP_435682.1 TIGRFAMsMatches:TIGR01558 YP_435685.1 COG3668 YP_435686.1 COG3609 YP_435687.1 COG0454 YP_435688.1 COG1403 YP_435692.1 Retron-type reverse transcriptase; COG3344 YP_435697.1 COG3293 YP_435698.1 COG3293 YP_435699.1 COG0582 YP_435700.1 COG0789 YP_435701.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_435702.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_435703.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_435704.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_435705.1 TIGRFAMsMatches:TIGR00001 YP_435706.1 COG0290 YP_435707.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_435708.1 COG1192 YP_435709.1 COG2358 YP_435710.1 COG1033 YP_435711.1 COG4447 YP_435713.1 COG0308 YP_435715.1 COG3139 YP_435716.1 COG0705; similar to Drosophila rhomboid YP_435717.1 COG0639 YP_435718.1 catalyzes the phosphorylation of NAD to NADP YP_435720.1 COG2515 YP_435721.1 COG0419 YP_435722.1 COG1902 YP_435723.1 COG2207 YP_435724.1 TIGRFAMsMatches:TIGR00068 YP_435729.1 COG0041 YP_435730.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_435732.1 COG0605 YP_435733.1 COG5001 YP_435734.1 COG1704 YP_435735.1 COG0501 YP_435736.1 COG1450 YP_435737.1 TIGRFAMsMatches:TIGR01713 YP_435739.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_435740.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_435741.1 Protein affecting phage T7 exclusion by the F plasmid COG3030 YP_435742.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_435743.1 COG3695 YP_435744.1 COG0477 YP_435745.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_435746.1 COG3706 YP_435748.1 COG1070 YP_435749.1 COG0578 YP_435750.1 COG0277 YP_435751.1 COG2207 YP_435752.1 COG1396 YP_435756.1 COG1804 YP_435757.1 COG2207 YP_435758.1 COG3706 YP_435761.1 COG2227 YP_435764.1 COG0664 YP_435765.1 COG2114; some protein contain HAMP domain YP_435766.1 COG0457 YP_435768.1 COG2233 YP_435769.1 COG0500 YP_435772.1 COG2169 YP_435773.1 COG0350 YP_435774.1 COG0697 YP_435775.1 COG0640 YP_435776.1 COG0346 YP_435777.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate YP_435778.1 COG0477 YP_435780.1 COG0840 YP_435783.1 COG0840 YP_435785.1 COG0564 YP_435787.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_435788.1 COG1131 YP_435789.1 COG1277 YP_435792.1 COG0642 YP_435796.1 COG0515 YP_435799.1 COG0277 YP_435801.1 Sugar transferase involved in lipopolysaccharide synthesis COG2148 YP_435803.1 uncharacterized protein involved in exopolysaccharide biosynthesis COG3206 YP_435804.1 COG1596 YP_435806.1 Predicted UDP-glucose 6-dehydrogenase; COG1004 YP_435807.1 Teichoic acid biosynthesis protein; COG1922 YP_435808.1 COG0438 YP_435809.1 Lipid A core - O-antigen ligase and related enzyme COG3307 YP_435811.1 COG0463 YP_435813.1 COG1216 YP_435814.1 Exopolysaccharide biosynthesis protein; COG5039 YP_435815.1 COG2244 YP_435816.1 COG0463 YP_435821.1 COG1696 YP_435823.1 COG0583 YP_435824.1 COG1858 YP_435828.1 COG0513 YP_435829.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_435830.1 COG1278 YP_435834.1 COG0457 YP_435835.1 COG0639 YP_435836.1 COG0583 YP_435837.1 COG2855 YP_435839.1 COG2453 YP_435840.1 COG1352 YP_435842.1 COG0835 YP_435843.1 COG1261 YP_435844.1 COG2747 YP_435846.1 COG2804 YP_435847.1 COG3706 YP_435848.1 COG0652 YP_435849.1 COG4121 YP_435850.1 Predicted transcriptional regulator, contains C-terminal CBS domains COG2524 YP_435852.1 TIGRFAMsMatches:TIGR00575 YP_435853.1 TIGRFAMsMatches:TIGR02205 YP_435854.1 TIGRFAMsMatches:TIGR02168 YP_435856.1 COG1802 YP_435858.1 COG3706 YP_435859.1 COG1187 YP_435860.1 TIGRFAMsMatches:TIGR00281 YP_435861.1 COG1354 YP_435862.2 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_435863.1 COG0074 YP_435864.1 catalyzes the interconversion of succinyl-CoA and succinate YP_435865.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_435866.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_435867.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_435868.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_435869.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_435870.1 COG2142 YP_435871.1 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit COG2009 YP_435872.1 TIGRFAMsMatches:TIGR01798 YP_435873.1 COG2084 YP_435874.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_435876.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_435877.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_435880.1 COG0589 YP_435882.1 COG0488 YP_435883.1 COG3217 YP_435884.1 COG0835 YP_435885.1 COG3226 YP_435886.1 COG3803 YP_435887.1 COG2138 YP_435888.1 COG1090 YP_435889.1 COG1309 YP_435890.1 COG2050 YP_435892.1 TIGRFAMsMatches:TIGR00409 YP_435893.1 COG0741 YP_435894.1 COG0494 YP_435896.1 COG2902 YP_435899.1 COG0714 YP_435900.1 COG1721 YP_435901.1 COG1113 YP_435902.1 COG2304 YP_435903.1 COG2304 YP_435908.1 COG3360 YP_435909.1 COG2764 YP_435910.1 COG3525 YP_435911.1 COG2273 YP_435912.1 COG3325 YP_435915.1 COG1609 YP_435921.1 COG3022 YP_435922.1 COG0526 YP_435923.1 TIGRFAMsMatches:TIGR02188 YP_435924.1 COG0583 YP_435925.1 COG2259 YP_435926.1 COG3384 YP_435927.1 hemolysin III-like protein; COG1272 YP_435928.1 COG0840 YP_435929.1 COG0834 YP_435930.1 COG0834 YP_435931.1 COG2315 YP_435932.1 COG2272 YP_435933.1 Required for efficient pilin antigenic variation YP_435934.1 COG1042 YP_435935.1 COG0123 YP_435936.1 TIGRFAMsMatches:TIGR00208 YP_435937.1 COG1345 YP_435938.1 COG1334 YP_435939.1 COG1344 YP_435940.1 COG2604 YP_435941.1 COG1344 YP_435942.1 COG0457 YP_435943.1 COG1045 YP_435944.1 COG0107 YP_435945.1 TIGRFAMsMatches:TIGR01855 YP_435946.1 COG0037 YP_435947.1 COG1028 YP_435950.1 catalyzes the formation of 5-aminovulinate from (S)-4-amino-5-oxopentanoate YP_435951.1 COG1083 YP_435952.1 translation initiation factor 2B, gamma/epsilon subunit (eIF-2Bgamma/eIF-2Bepsilon); COG1208 YP_435953.1 COG0110 YP_435954.1 COG2089 YP_435955.1 COG0381 YP_435956.1 COG0399 YP_435957.1 COG0451 YP_435958.1 COG3222 YP_435959.1 COG0463 YP_435960.1 COG0535 YP_435961.1 COG0454 YP_435962.1 COG1670 YP_435965.1 COG1522 YP_435966.1 COG2340 YP_435967.1 COG0639 YP_435968.1 COG0840 YP_435969.1 COG3540 YP_435974.1 COG0818 YP_435975.1 COG0583 YP_435977.1 COG0477 YP_435978.1 4-oxalocrotonate tautomerase-like protein; COG1942 YP_435980.1 COG2866 YP_435985.1 COG1234 YP_435986.1 COG0583 YP_435988.1 COG2110; similar to the C-terminal domain of histone macroH2A1 YP_435989.1 COG0346 YP_435990.1 COG0673 YP_435991.1 COG0840 YP_435993.1 COG1881 YP_435997.1 COG2207 YP_435999.1 COG0834 YP_436000.1 COG2095 YP_436001.1 COG0655 YP_436003.1 COG0515 YP_436004.1 COG1595 YP_436006.1 COG0318 YP_436008.1 COG1408 YP_436009.1 COG0451 YP_436011.1 COG0209 YP_436012.1 COG0209 YP_436013.1 TIGRFAMsMatches:TIGR01099 YP_436015.1 COG0303 YP_436016.1 COG0521 YP_436017.1 COG0288 YP_436018.1 COG0451 YP_436020.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_436021.1 COG3317 YP_436022.1 TIGRFAMsMatches:TIGR00674 YP_436023.1 COG2716 YP_436024.1 COG1225 YP_436025.1 COG0628 YP_436026.1 COG0425 YP_436027.1 COG4783 YP_436028.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_436029.1 COG1729 YP_436030.1 COG2885 YP_436031.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_436033.1 COG0848 YP_436034.1 COG0811 YP_436035.1 COG0824 YP_436036.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_436037.1 TIGRFAMsMatches:TIGR00084 YP_436038.1 TIGRFAMsMatches:TIGR00228 YP_436040.1 COG0217 YP_436041.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_436042.1 COG2331 YP_436043.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_436045.1 COG0642 YP_436046.1 COG0784 YP_436047.1 COG0642 YP_436049.1 COG2206 YP_436050.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_436051.1 COG0537 YP_436052.1 COG1004 YP_436053.1 TIGRFAMsMatches:TIGR01179 YP_436054.1 COG0590 YP_436055.1 COG1835 YP_436056.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_436057.1 TIGRFAMsMatches:TIGR01302 YP_436058.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_436059.1 COG2050 YP_436060.1 COG2050 YP_436061.1 COG3821 YP_436062.1 COG4784 YP_436063.1 COG0596 YP_436065.1 COG3127 YP_436066.1 COG4181 YP_436067.1 COG2755; similar to related esterases YP_436069.1 COG0840 YP_436070.1 COG0589 YP_436072.1 catalyzes the removal of amino acids from the N termini of peptides YP_436078.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_436079.1 COG3130 YP_436080.1 TIGRFAMsMatches:TIGR01036 YP_436082.1 COG0053 YP_436085.1 COG1322 YP_436086.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_436087.1 COG0436 YP_436089.1 COG0284 YP_436090.1 COG2956 YP_436092.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_436093.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_436094.1 TIGRFAMsMatches:TIGR00017 YP_436095.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate and catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_436096.1 COG0077 YP_436097.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_436098.1 TIGRFAMsMatches:TIGR01063 YP_436099.1 COG0517 YP_436100.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_436101.1 COG2154 YP_436102.1 COG1951 YP_436104.1 TIGRFAMsMatches:TIGR00032 YP_436105.1 COG2885 YP_436106.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_436107.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_436108.1 COG0450 YP_436109.1 COG1028 YP_436110.1 TIGRFAMsMatches:TIGR01829 YP_436112.1 COG1025 YP_436113.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_436115.1 COG0009 YP_436116.1 COG0271 YP_436118.1 COG0745 YP_436120.1 COG0642 YP_436123.1 Predicted carboxypeptidase; COG2866 YP_436124.1 COG0596 YP_436125.1 COG2885 YP_436126.1 COG5001 YP_436127.1 COG5008 YP_436130.1 COG0500 YP_436131.1 COG1205 YP_436134.1 COG2333 YP_436135.1 COG4096 YP_436136.1 COG0732 YP_436137.1 COG0286 YP_436139.1 COG3655 YP_436140.1 COG2801 YP_436141.1 COG0431 YP_436142.1 COG1028 YP_436143.1 COG2068 YP_436144.1 COG1529 YP_436145.1 COG2080 YP_436149.1 COG2840 YP_436150.1 COG2314 YP_436151.1 COG1451 YP_436152.1 COG0840 YP_436153.1 COG1020 YP_436155.1 COG1024 YP_436159.1 COG2905 YP_436160.1 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases COG0847 YP_436161.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_436162.1 COG1454 YP_436164.1 COG1396 YP_436167.1 COG2872 YP_436169.1 COG1690 YP_436176.1 COG3123 YP_436178.1 COG4147 YP_436179.1 COG4327 YP_436180.1 COG0591 YP_436181.1 COG2197 YP_436182.1 TIGRFAMsMatches:TIGR02188 YP_436183.1 COG3320 YP_436184.1 COG1073 YP_436185.1 COG2226 YP_436186.1 COG2898 YP_436187.1 TIGRFAMsMatches:TIGR00067 YP_436188.1 COG2816 YP_436189.1 COG3225 YP_436190.1 COG1277 YP_436191.1 COG1131 YP_436192.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_436193.1 COG2197 YP_436194.1 COG0642 YP_436196.1 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) COG1080 YP_436198.1 COG3791 YP_436204.1 COG0457 YP_436207.1 COG4789 YP_436213.1 Flagellar biosynthesis/type III secretory pathway ATPase; COG1157 YP_436216.1 Flagellar motor switch/type III secretory pathway protein; COG1886 YP_436217.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response YP_436218.1 COG4794 YP_436219.1 COG4791 YP_436220.1 COG4792 YP_436221.1 COG0834 YP_436222.1 COG0123 YP_436223.1 COG0454 YP_436225.1 COG1317 YP_436227.1 COG4669 YP_436236.1 COG1450 YP_436241.1 COG1595 YP_436243.1 COG3899 YP_436245.1 COG1309 YP_436246.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_436247.1 COG0477 YP_436248.1 COG1846 YP_436249.1 COG1522 YP_436251.2 TIGRFAMsMatches:TIGR00970 YP_436252.1 COG0402 YP_436253.1 COG3141 YP_436254.1 COG0642 YP_436255.1 COG4566 YP_436260.1 COG0474 YP_436265.1 COG0835 YP_436267.1 COG1192 YP_436268.1 Homologous to MotB. These organism have both MotB and MotD. With MotC (a MotA homolog) forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine. Either MotAB or MotCD is sufficient for swimming, but both are necessary for swarming motility YP_436269.1 homologous to MotA; this protein with a related protein (a MotB homolog) forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; either MotAB or MotCD is sufficient for swimming, but both are necessary for swarming motility; these organisms have both MotA and MotC YP_436270.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_436271.1 COG0643 YP_436272.1 COG3143 YP_436273.1 COG0784 YP_436274.1 DNA-directed RNA polymerase specialized sigma subunit COG1191 YP_436275.1 ATPase involved in chromosome partitioning; COG0455 YP_436276.1 COG1419 YP_436277.1 membrane protein involved in the flagellar export apparatus YP_436278.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_436279.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_436280.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_436281.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_436282.1 COG3190 YP_436283.1 One of three proteins involved in switching the direction of the flagellar rotation YP_436284.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_436285.1 COG1580 YP_436286.1 COG3144 YP_436287.1 COG2198 YP_436288.1 COG3706 YP_436292.1 COG2882 YP_436293.1 involved in type III protein export during flagellum assembly YP_436294.1 Flagellar biosynthesis/type III secretory pathway protein; COG1317 YP_436295.1 One of three proteins involved in switching the direction of the flagellar rotation YP_436296.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_436297.1 TIGRFAMsMatches:TIGR00205 YP_436298.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_436299.1 COG5000 YP_436300.1 Retron-type reverse transcriptase; COG3344 YP_436303.1 COG1883 YP_436304.1 catalyzes the formation of pyruvate from oxaloacetate YP_436307.1 TIGRFAMsMatches:TIGR00202 YP_436309.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_436310.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_436312.1 COG1575 YP_436313.1 COG1714 YP_436314.1 COG4598 YP_436315.1 COG0834 YP_436316.1 COG4215 YP_436317.1 COG4160 YP_436318.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_436319.1 COG0642 YP_436320.1 COG4566 YP_436321.1 COG0739 YP_436322.1 COG1180 YP_436323.1 COG3145 YP_436325.1 COG1226 YP_436326.1 COG1067 YP_436328.1 COG0746 YP_436329.1 COG0314 YP_436330.1 COG3094 YP_436332.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_436333.1 COG1546 YP_436334.1 This protein performs the mismatch recognition step during the DNA repair process YP_436335.1 COG1146 YP_436336.1 COG0542 YP_436337.1 COG0164 YP_436338.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_436339.1 TIGRFAMsMatches:TIGR01852 YP_436340.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_436341.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_436342.1 COG2825 YP_436344.1 COG4775 YP_436345.1 COG0750 YP_436346.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_436347.1 COG0575 YP_436348.1 TIGRFAMsMatches:TIGR00055 YP_436349.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_436350.1 Catalyzes the phosphorylation of UMP to UDP YP_436351.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_436352.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_436353.1 TIGRFAMsMatches:TIGR00500 YP_436354.1 Catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_436355.1 catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate YP_436357.1 COG1393 YP_436358.1 COG2171 YP_436359.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_436362.1 COG1278 YP_436363.1 uncharacterized protein conserved in bacteria COG2900 YP_436364.1 COG1083 YP_436365.1 COG2089 YP_436368.1 Membrane protein involved in the export of O-antigen and teichoic acid COG2244 YP_436370.1 COG0463 YP_436371.1 COG1215 YP_436372.1 COG0438 YP_436373.1 COG0463 YP_436375.1 COG4969 YP_436376.1 COG4969 YP_436377.1 COG2804 YP_436378.1 COG1459 YP_436379.1 COG1989 YP_436380.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_436381.1 COG3024 YP_436383.1 COG1720 YP_436385.1 COG0642 YP_436387.1 COG0025 YP_436391.1 COG2992 YP_436392.1 COG3339 YP_436393.1 COG0204 YP_436395.1 COG0747 YP_436397.1 COG0183 YP_436398.1 COG1485 YP_436399.1 COG3105 YP_436400.1 COG0327 YP_436401.1 COG0265 YP_436402.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_436403.1 COG0141 YP_436404.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_436405.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_436407.1 COG5007 YP_436408.1 COG3113 YP_436409.1 COG2854 YP_436410.1 COG1463 YP_436411.1 COG0767 YP_436412.1 COG1127 YP_436413.1 COG0794 YP_436414.1 COG1778 YP_436415.1 COG3117 YP_436416.1 COG1934 YP_436417.1 COG1137 YP_436418.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_436419.1 COG1544 YP_436420.1 TIGRFAMsMatches:TIGR01419 YP_436421.1 COG1660 YP_436422.1 Phosphotransferase system, HPr-related protein; COG1925 YP_436423.1 TIGRFAMsMatches:TIGR00400 YP_436424.1 COG3028 YP_436425.1 COG0388 YP_436426.1 COG3164 YP_436427.1 COG1530 YP_436428.1 TIGRFAMsMatches:TIGR00172 YP_436429.1 COG2891 YP_436430.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_436431.1 functions in MreBCD complex in some organisms YP_436433.1 TIGRFAMsMatches:TIGR00135 YP_436434.1 TIGRFAMsMatches:TIGR00132 YP_436435.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_436436.1 COG0621 YP_436439.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_436440.1 COG2895 YP_436442.1 COG0075 YP_436443.1 COG3081 YP_436444.1 COG4517 YP_436445.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_436446.1 COG1702 YP_436447.1 COG0319 YP_436448.1 COG4535 YP_436449.1 Transfers the fatty acyl group on membrane lipoproteins YP_436450.1 COG3590 YP_436452.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_436453.1 COG2980 YP_436454.1 COG1466 YP_436456.1 COG2356 YP_436457.1 COG1960 YP_436458.1 COG1960 YP_436460.1 COG1749 YP_436461.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_436462.1 COG0500 YP_436463.1 COG0596 YP_436464.1 TIGRFAMsMatches:TIGR00858 YP_436465.1 TIGRFAMsMatches:TIGR00433 YP_436466.1 COG1040 YP_436467.1 COG0579 YP_436468.1 COG0697 YP_436469.1 COG3268 YP_436471.1 TIGRFAMsMatches:TIGR00184 YP_436472.1 COG3705 YP_436473.1 COG3242 YP_436474.1 TIGRFAMsMatches:TIGR01932 YP_436475.1 TIGRFAMsMatches:TIGR01933 YP_436476.1 COG2262 YP_436477.1 COG1923 YP_436478.1 TIGRFAMsMatches:TIGR00174 YP_436479.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_436481.1 COG0860 YP_436482.1 COG0802 YP_436483.1 COG0062 YP_436484.1 TIGRFAMsMatches:TIGR00276 YP_436485.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_436486.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_436487.1 COG1360 YP_436488.1 COG1291 YP_436490.1 COG2897 YP_436491.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_436492.1 COG2269 YP_436493.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_436494.1 COG1509 YP_436495.1 COG0050 YP_436496.1 COG5001 YP_436497.1 TIGRFAMsMatches:TIGR00338 YP_436498.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_436500.1 COG0741 YP_436501.1 COG2829 YP_436502.1 COG1533 YP_436503.1 COG1946 YP_436504.1 COG0715 YP_436505.1 COG3853 YP_436507.1 COG0715 YP_436508.1 COG2304 YP_436509.1 COG0715 YP_436510.1 COG1116 YP_436511.1 COG0600 YP_436514.1 COG0262 YP_436515.1 COG0834 YP_436520.1 COG1033 YP_436521.1 COG0607 YP_436522.1 COG0640 YP_436523.1 COG0477 YP_436524.1 COG1566 YP_436525.1 COG1309 YP_436526.1 COG1670 YP_436528.1 COG0454 YP_436529.1 COG4912 YP_436530.1 COG5472 YP_436531.1 COG0834 YP_436532.1 Transcriptional regulator containing an AAA-type ATPase domain and a DNA-binding domain; COG1221 YP_436533.1 COG1842 YP_436534.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_436535.1 putative stress-responsive transcriptional regulator; COG1983 YP_436536.1 COG2824 YP_436542.1 COG2941 YP_436543.1 COG3469 YP_436545.1 COG0642 YP_436546.1 COG3706 YP_436547.1 COG4771 YP_436549.1 COG3720 YP_436550.1 COG4558 YP_436551.1 COG0609 YP_436552.1 COG4559 YP_436553.1 COG0834 YP_436559.1 COG1280 YP_436561.1 COG3791 YP_436564.1 COG3293 YP_436567.1 COG0841 YP_436568.1 COG0845 YP_436569.1 COG1309 YP_436571.1 COG0583 YP_436575.1 COG0834 YP_436576.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_436577.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_436578.1 catalyzes the degradation of arginine to citruline and ammonia YP_436579.1 COG0531 YP_436580.1 COG3237 YP_436584.1 COG0542 YP_436585.1 COG0542 YP_436586.1 COG0542 YP_436587.1 COG2366 YP_436588.1 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain; COG4650 YP_436592.1 COG1403 YP_436595.1 COG0574 YP_436596.1 COG1520 YP_436597.1 COG1741 YP_436599.1 COG2977 YP_436603.1 COG1607 YP_436606.1 COG0332 YP_436607.1 COG0451 YP_436608.1 COG0491 YP_436609.1 COG1541 YP_436612.1 COG4638 YP_436615.1 COG2135 YP_436617.1 COG0583 YP_436618.1 COG0384 YP_436619.1 COG1280 YP_436620.1 COG2329 YP_436622.1 COG0640 YP_436628.1 COG0443 YP_436630.1 COG5184 YP_436632.1 COG1840 YP_436633.1 COG2197 YP_436635.1 COG0642 YP_436638.1 COG3357 YP_436644.1 COG2867 YP_436645.1 COG0596 YP_436646.1 COG2326 YP_436647.1 COG3000 YP_436650.1 COG0714 YP_436653.1 COG2207 YP_436655.1 COG0454 YP_436656.1 COG1278 YP_436658.1 TIGRFAMsMatches:TIGR02063 YP_436659.1 COG2162 YP_436660.1 COG0697 YP_436661.1 COG0664 YP_436663.1 COG2169 YP_436664.1 COG3826 YP_436671.1 COG1309 YP_436672.1 COG2319 YP_436673.1 COG0457 YP_436674.1 COG0726 YP_436675.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_436677.1 COG1115 YP_436678.1 COG4941 YP_436679.1 COG3795 YP_436680.1 COG4319 YP_436681.1 COG3795 YP_436684.1 COG0841 YP_436685.1 COG0845 YP_436694.1 COG3335 YP_436697.1 COG3415 YP_436702.1 COG1396 YP_436704.1 COG1309 YP_436708.1 DNA invertase Pin-like protein; COG1961 YP_436710.1 COG0454 YP_436711.1 COG4453 YP_436714.1 COG2003 YP_436718.1 Transposase and inactivated derivatives COG4584 YP_436719.1 DNA replication protein; COG1484 YP_436721.1 COG3440 YP_436722.1 COG3293 YP_436726.1 COG3209 YP_436735.1 COG5449 YP_436749.1 COG0616 YP_436750.1 TIGRFAMsMatches:TIGR01539 YP_436752.1 COG5525 YP_436762.1 COG0863 YP_436765.1 COG0817 YP_436766.1 COG3378 YP_436776.1 COG1396 YP_436779.1 DNA invertase Pin-like protein; COG1961 YP_436782.1 COG2003 YP_436783.1 COG3501 YP_436784.1 COG5351 YP_436785.1 COG0304 YP_436791.1 COG0210 YP_436793.1 COG0210 YP_436798.1 COG3727 YP_436799.1 COG0270 YP_436803.1 COG0397 YP_436808.1 COG0286 YP_436809.1 COG1714 YP_436810.1 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) COG0189 YP_436812.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_436813.1 COG1404 YP_436814.1 COG0154 YP_436815.1 COG0491 YP_436817.1 COG5001 YP_436818.1 COG3706 YP_436819.1 COG0784 YP_436820.1 COG0834 YP_436822.1 COG1309 YP_436823.1 COG0433 YP_436824.1 COG1028 YP_436825.1 COG4799 YP_436826.1 COG1960 YP_436827.1 COG1024 YP_436828.1 COG4770 YP_436829.1 COG1028 YP_436830.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization YP_436831.1 COG5001 YP_436832.1 COG0513 YP_436840.1 COG1028 YP_436841.1 COG0583 YP_436842.1 COG0653 YP_436843.1 COG3718 YP_436844.1 COG0673 YP_436848.1 COG1737 YP_436849.1 COG0673 YP_436850.1 COG1638 YP_436851.1 COG3090 YP_436852.1 COG1593 YP_436853.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_436854.1 COG2898 YP_436855.1 COG1055 YP_436856.1 COG0564 YP_436859.1 COG2050 YP_436861.1 COG1309 YP_436865.1 COG1960 YP_436866.1 COG0748 YP_436867.1 COG3784 YP_436871.1 COG2607 YP_436872.1 COG0163 YP_436873.1 TIGRFAMsMatches:TIGR01081 YP_436874.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_436875.1 COG1309 YP_436877.1 COG3556 YP_436878.1 COG1522 YP_436879.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_436880.1 COG0247 YP_436881.1 COG0277 YP_436882.1 COG0277 YP_436883.1 COG0834 YP_436884.1 COG4597 YP_436885.1 COG0765 YP_436886.1 COG1126 YP_436887.1 COG0454 YP_436888.1 COG0384 YP_436892.1 COG3240 YP_436893.1 COG0515 YP_436894.1 COG2223 YP_436896.1 COG1251 YP_436897.1 COG2146 YP_436898.1 COG0243 YP_436899.1 COG0346 YP_436900.1 COG0834 YP_436901.1 COG1785 YP_436902.1 COG0745 YP_436903.1 COG3706 YP_436905.1 COG0683 YP_436906.1 COG0840 YP_436907.1 COG0643 YP_436910.1 COG0661 YP_436911.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_436912.1 TIGRFAMsMatches:TIGR00214 YP_436913.1 COG2921 YP_436914.1 COG1686 YP_436915.1 COG0797 YP_436916.1 TIGRFAMsMatches:TIGR02282 YP_436917.1 TIGRFAMsMatches:TIGR02210 YP_436918.1 COG0768 YP_436919.1 COG1576 YP_436920.1 COG0799 YP_436921.1 TIGRFAMsMatches:TIGR00482 YP_436922.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_436923.1 COG2199 YP_436924.1 COG3706 YP_436925.1 COG0586 YP_436926.1 COG2802; similar to the N-terminal domain of Lon protease YP_436927.1 COG1226 YP_436928.1 COG1639 YP_436929.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_436930.1 TIGRFAMsMatches:TIGR01970 YP_436931.1 COG0262 YP_436932.1 COG0207 YP_436933.1 TIGRFAMsMatches:TIGR00544 YP_436934.1 COG0730 YP_436935.1 COG3332 YP_436937.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; Vibrio parahaemolyticus protein is associated with the polar flagella YP_436938.1 Homologous to MotA in E. coli and Salmonella. With PomB forms the ion channels that couple flagellar rotation to sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine. YP_436939.1 TIGRFAMsMatches:TIGR01280 YP_436940.1 COG0142 YP_436941.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_436942.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_436943.1 COG2896 YP_436944.1 COG1977 YP_436945.1 TIGRFAMsMatches:TIGR00581 YP_436946.1 COG0494 YP_436947.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_436948.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_436949.1 COG0739 YP_436951.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_436952.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_436953.1 TIGRFAMsMatches:TIGR01174 YP_436954.1 COG1589 YP_436955.1 COG1181 YP_436956.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_436957.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_436958.1 COG0772 YP_436959.1 TIGRFAMsMatches:TIGR01087 YP_436960.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_436961.1 COG0770 YP_436962.1 COG0769 YP_436963.1 Cell division protein FtsI/penicillin-binding protein 2 COG0768 YP_436964.1 TIGRFAMsMatches:TIGR02209 YP_436965.1 TIGRFAMsMatches:TIGR00006 YP_436966.1 COG2001 YP_436967.1 COG0313 YP_436968.1 COG3107 YP_436969.1 COG0792 YP_436970.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_436971.1 COG2969 YP_436972.1 COG0625 YP_436973.1 COG2857 YP_436974.1 COG1290 YP_436975.1 TIGRFAMsMatches:TIGR01416 YP_436976.1 COG0103 YP_436977.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_436978.1 COG0084 YP_436979.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_436981.1 TIGRFAMsMatches:TIGR01575 YP_436983.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_436985.1 COG3335 YP_436987.1 COG2717 YP_436988.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_436989.1 TIGRFAMsMatches:TIGR00473 YP_436990.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_436991.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_436992.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit YP_436994.1 COG0542 YP_436995.1 COG1496 YP_436996.1 COG0564 YP_436997.1 COG4105 YP_436998.1 COG0171 YP_436999.1 COG0642 YP_437000.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_437001.1 COG4970 YP_437002.1 COG4968 YP_437003.1 COG3419 YP_437005.1 COG4966 YP_437006.1 COG4970 YP_437007.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_437008.1 COG1047 YP_437009.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_437010.1 TIGRFAMsMatches:TIGR00392 YP_437011.1 TIGRFAMsMatches:TIGR00083 YP_437012.1 TIGRFAMsMatches:TIGR01695 YP_437014.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_437015.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_437016.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_437017.1 involved in the peptidyltransferase reaction during translation YP_437018.1 TIGRFAMsMatches:TIGR00061 YP_437019.1 COG0142 YP_437020.1 COG2194 YP_437021.1 COG2078 YP_437022.1 COG1355 YP_437027.1 COG1267 YP_437028.1 TIGRFAMsMatches:TIGR01379 YP_437029.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_437030.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_437031.1 COG0108 YP_437032.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_437033.1 TIGRFAMsMatches:TIGR00326 YP_437034.1 COG1327 YP_437035.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_437036.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_437038.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_437039.1 TIGRFAMsMatches:TIGR01464 YP_437040.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_437041.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_437042.1 COG3266 YP_437043.1 TIGRFAMsMatches:TIGR01357 YP_437044.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_437045.1 Type II secretory pathway, component HofQ COG4796 YP_437046.1 COG3168 YP_437047.1 COG3167 YP_437048.1 COG3166 YP_437049.1 COG4972 YP_437050.1 COG5009 YP_437051.1 COG0281 YP_437052.1 TIGRFAMsMatches:TIGR00105 YP_437053.1 TIGRFAMsMatches:TIGR00595 YP_437054.1 COG3087 YP_437055.1 heat shock protein involved in degradation of misfolded proteins YP_437056.1 heat shock protein involved in degradation of misfolded proteins YP_437057.1 COG3536 YP_437058.1 COG1752 YP_437059.1 COG3605 YP_437060.1 hydrolyzes diadenosine polyphosphate YP_437061.1 COG0560 YP_437063.1 COG1092 YP_437064.1 COG1639 YP_437065.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_437066.1 COG3150 YP_437067.1 COG1409 YP_437068.1 COG3151 YP_437069.1 COG0494 YP_437071.1 COG1538 YP_437072.1 COG1519 YP_437073.1 COG0578 YP_437074.1 COG0667 YP_437075.1 COG5345 YP_437076.1 COG2200 YP_437078.1 COG3706 YP_437079.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_437080.1 TIGRFAMsMatches:TIGR00531 YP_437081.1 TIGRFAMsMatches:TIGR00514 YP_437082.1 TIGRFAMsMatches:TIGR00406 YP_437084.1 COG0042 YP_437085.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_437086.1 involved in de novo purine biosynthesis YP_437087.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_437088.1 COG5001 YP_437089.1 COG0526 YP_437091.1 COG1956 YP_437092.1 COG0697 YP_437093.1 COG3706 YP_437095.1 TIGRFAMsMatches:TIGR00674 YP_437096.1 COG1960 YP_437098.1 COG0477 YP_437100.1 COG0574 YP_437103.1 COG4992 YP_437104.1 COG0500 YP_437105.1 COG0236 YP_437106.1 COG0156 YP_437107.1 COG1020 YP_437108.1 COG3321 YP_437111.1 COG0778 YP_437112.1 COG3752 YP_437115.1 COG3644 YP_437117.1 COG0642 YP_437118.1 COG0745 YP_437119.1 COG4675 YP_437120.1 COG4675 YP_437121.1 COG4675 YP_437129.1 COG0367 YP_437130.1 COG1132 YP_437132.1 COG0456 YP_437141.1 COG0834 YP_437143.1 COG0840 YP_437149.1 COG2207 YP_437150.1 COG2942 YP_437151.1 COG0524 YP_437152.1 COG2207 YP_437153.1 COG3839 YP_437154.1 COG0395 YP_437155.1 COG1175 YP_437156.1 COG1653 YP_437157.1 COG0642 YP_437158.1 COG0745 YP_437159.1 COG2860 YP_437160.1 COG1280 YP_437161.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_437164.1 COG3132 YP_437165.1 COG2214 YP_437168.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_437169.1 COG0483 YP_437170.1 COG0834 YP_437171.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_437173.1 COG2363 YP_437174.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_437175.1 protein associated with Co2+ and Mg2+ efflux YP_437176.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_437177.1 TIGRFAMsMatches:TIGR00557 YP_437178.1 COG0760 YP_437179.1 COG1452 YP_437180.1 COG1752 YP_437181.1 COG3178 YP_437182.1 translation initiation factor 2B, gamma/epsilon subunit (eIF-2Bgamma/eIF-2Bepsilon); COG1208 YP_437183.1 COG1076 YP_437185.1 TIGRFAMsMatches:TIGR01163 YP_437186.1 TIGRFAMsMatches:TIGR01449 YP_437187.1 COG2931 YP_437189.1 COG0845 YP_437190.1 COG2274 YP_437194.1 COG0583 YP_437195.1 COG1960 YP_437196.1 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit COG0022 YP_437197.1 COG0331 YP_437198.1 TIGRFAMsMatches:TIGR00564 YP_437199.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_437200.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_437201.1 COG0134 YP_437202.1 COG0583 YP_437203.1 COG5457 YP_437206.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_437207.1 COG1765 YP_437209.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_437210.1 COG0705; similar to Drosophila rhomboid YP_437211.1 COG3954 YP_437212.1 COG0464 YP_437217.1 COG2165 YP_437218.1 COG2165 YP_437220.1 COG1459 YP_437221.1 COG2804 YP_437222.1 COG0457 YP_437223.1 COG3267 YP_437224.1 COG1450 YP_437230.1 COG1045 YP_437231.1 COG1045 YP_437232.1 COG0236 YP_437233.1 COG3161 YP_437234.1 COG0318 YP_437235.1 COG1215 YP_437236.1 COG2605 YP_437237.1 COG0529 YP_437240.1 COG0438 YP_437242.1 COG1045 YP_437244.1 COG0845 YP_437246.1 COG2244 YP_437250.1 translation initiation factor 2B, gamma/epsilon subunit (eIF-2Bgamma/eIF-2Bepsilon); COG1208 YP_437251.1 TIGRFAMsMatches:TIGR00441 YP_437257.1 COG1181 YP_437258.1 COG0629 YP_437259.1 COG0477 YP_437260.1 TIGRFAMsMatches:TIGR00630 YP_437261.1 is a component of the macrolide binding site in the peptidyl transferase center YP_437262.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_437263.1 TIGRFAMsMatches:TIGR01017 YP_437264.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_437265.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_437266.1 TIGRFAMsMatches:TIGR01022 YP_437267.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_437268.1 TIGRFAMsMatches:TIGR01071 YP_437269.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_437270.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_437271.1 binds 5S rRNA along with protein L5 and L25 YP_437272.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_437273.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_437274.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_437275.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_437276.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_437277.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_437278.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_437279.1 TIGRFAMsMatches:TIGR00012 YP_437280.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_437281.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_437282.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_437283.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_437284.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_437285.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_437286.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_437287.1 COG0087 YP_437288.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_437289.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_437290.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_437291.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_437292.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_437293.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_437294.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_437295.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_437296.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_437297.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_437298.1 TIGRFAMsMatches:TIGR01632 YP_437299.1 Modulates Rho-dependent transcription termination YP_437300.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_437301.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_437304.1 COG1521; similar to Bvg accessory factor YP_437305.1 COG0340 YP_437306.1 DNA replication protein; COG1484 YP_437307.1 Transposase and inactivated derivatives COG4584 YP_437310.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_437311.1 COG0739 YP_437312.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_437314.1 COG0316 YP_437315.1 COG1664 YP_437317.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_437318.1 COG0038 YP_437319.1 COG1981 YP_437320.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_437322.1 TIGRFAMsMatches:TIGR02071 YP_437323.1 COG2187 YP_437324.1 COG1357 YP_437325.1 COG0664 YP_437326.1 COG2146 YP_437327.1 TIGRFAMsMatches:TIGR00230 YP_437328.1 COG1734 YP_437329.1 Glutamyl- and glutaminyl-tRNA synthetase; COG0008 YP_437331.1 COG0591 YP_437332.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_437334.1 COG0617 YP_437335.1 TIGRFAMsMatches:TIGR01498 YP_437336.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_437337.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_437338.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_437339.1 TIGRFAMsMatches:TIGR01498 YP_437340.1 TIGRFAMsMatches:TIGR00525 YP_437341.1 COG0344 YP_437342.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_437343.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_437344.1 COG1610 YP_437345.1 COG0358 YP_437346.1 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32); COG0568 YP_437354.1 COG1396 YP_437356.1 COG2856 YP_437358.1 COG0625 YP_437360.1 COG2207 YP_437362.1 COG0006 YP_437363.1 COG1012 YP_437364.1 COG1473 YP_437365.1 COG1292 YP_437366.1 COG0583 YP_437367.1 COG1028 YP_437369.1 COG3803 YP_437371.1 COG0642 YP_437372.1 COG0840 YP_437373.1 COG0739 YP_437374.1 COG1723 YP_437375.1 COG4301 YP_437376.1 COG1262 YP_437380.1 COG1639 YP_437381.1 catalyzes branch migration in Holliday junction intermediates YP_437382.1 COG0583 YP_437383.1 COG0451 YP_437384.1 COG0251 YP_437385.1 COG0317 YP_437386.1 TIGRFAMsMatches:TIGR00690 YP_437387.1 COG0194 YP_437388.1 COG0583 YP_437389.1 COG0518 YP_437390.1 COG1454 YP_437391.1 COG1012 YP_437392.1 COG0174 YP_437393.1 COG0531 YP_437395.1 COG1485 YP_437401.1 COG0500 YP_437402.1 COG3415 YP_437403.1 COG1373 YP_437404.1 COG1061 YP_437405.1 DNA replication protein; COG1484 YP_437406.1 Transposase and inactivated derivatives COG4584 YP_437407.1 COG1561 YP_437409.1 TIGRFAMsMatches:TIGR01966 YP_437410.1 COG0708 YP_437411.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_437412.1 COG0730 YP_437413.1 COG0488 YP_437416.1 COG3174 YP_437417.1 COG0826 YP_437419.1 TIGRFAMsMatches:TIGR00938 YP_437421.1 DNA polymerase I - 3'-5' exonuclease and polymerase domains COG0749 YP_437422.1 COG5008 YP_437423.1 COG2805 YP_437424.1 COG0325 YP_437425.1 TIGRFAMsMatches:TIGR00112 YP_437426.1 COG0762 YP_437427.1 COG1872 YP_437428.1 COG0699 YP_437429.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_437430.1 TIGRFAMsMatches:TIGR02081 YP_437432.1 TIGRFAMsMatches:TIGR00042 YP_437433.1 COG0635 YP_437435.1 TIGRFAMsMatches:TIGR00091 YP_437438.1 COG0606 YP_437443.1 COG1396 YP_437445.1 COG2003 YP_437446.1 COG1437 YP_437447.1 COG0499 YP_437448.1 COG0433 YP_437452.1 COG3335 YP_437453.1 COG3415 YP_437459.1 DNA invertase Pin-like protein; COG1961 YP_437464.1 COG0232 YP_437465.1 COG0758 YP_437466.1 DNA invertase Pin-like protein; COG1961 YP_437467.1 COG0606 YP_437468.1 COG2960 YP_437469.1 COG0347 YP_437470.1 TIGRFAMsMatches:TIGR00836 YP_437471.1 COG4095 YP_437472.1 COG3034 YP_437473.1 COG0304 YP_437474.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_437475.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_437476.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_437477.1 COG0366 YP_437478.1 COG0783 YP_437479.1 COG0642 YP_437480.1 COG0745 YP_437482.1 COG3134 YP_437483.1 COG1309 YP_437484.1 COG0625 YP_437485.1 COG0625 YP_437486.1 COG2319 YP_437487.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_437488.1 COG1495 YP_437490.1 COG1580 YP_437492.1 involved in the first step of glutathione biosynthesis YP_437493.1 COG2183 YP_437494.1 COG2200 YP_437497.1 TIGRFAMsMatches:TIGR01074 YP_437498.1 COG2129 YP_437500.1 COG5631 YP_437501.1 COG0145 YP_437502.1 COG1593 YP_437503.1 COG3090 YP_437504.1 COG1638 YP_437506.1 COG3245 YP_437509.1 COG1109 YP_437510.1 COG3382 YP_437514.1 COG0834 YP_437515.1 COG0666 YP_437516.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_437517.1 COG4181 YP_437518.1 COG3127 YP_437519.1 COG0477 YP_437520.1 COG0656 YP_437523.1 COG0188 YP_437526.1 COG0366 YP_437527.1 COG1609 YP_437529.1 COG0778 YP_437530.1 COG0079 YP_437531.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_437533.1 COG5446 YP_437534.1 TIGRFAMsMatches:TIGR02030 YP_437535.1 TIGRFAMsMatches:TIGR00708 YP_437536.1 COG1797 YP_437537.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_437538.1 COG2099 YP_437539.1 COG2138 YP_437540.1 COG2082 YP_437541.1 TIGRFAMsMatches:TIGR01468 YP_437542.1 TIGRFAMsMatches:TIGR01467 YP_437543.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_437544.1 COG1010 YP_437545.1 TIGRFAMsMatches:TIGR01465 YP_437549.1 COG2010 YP_437550.1 COG0454 YP_437552.1 COG0789 YP_437554.1 COG1280 YP_437557.1 COG0625 YP_437560.1 COG1278 YP_437561.1 COG0346 YP_437562.1 COG1238 YP_437566.1 COG1280 YP_437567.1 COG2207 YP_437569.1 COG0523 YP_437570.1 TIGRFAMsMatches:TIGR02257 YP_437571.1 COG0454 YP_437572.1 COG1284 YP_437573.1 COG2606 YP_437575.1 COG0454 YP_437578.1 COG0604 YP_437579.1 COG0583 YP_437582.1 COG3211 YP_437583.1 COG1653 YP_437587.1 COG4977 YP_437588.1 COG2220 YP_437591.1 COG4886 YP_437592.1 COG2954 YP_437593.1 COG0477 YP_437595.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_437603.1 COG0790 YP_437609.1 COG2003 YP_437613.1 COG3791 YP_437615.1 COG2374 YP_437616.1 COG0123 YP_437617.1 TIGRFAMsMatches:TIGR01292 YP_437620.1 COG3675 YP_437622.1 COG0524 YP_437623.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein YP_437626.1 COG1169 YP_437627.1 TIGRFAMsMatches:TIGR02275 YP_437628.1 COG1535 YP_437629.1 COG1020 YP_437630.1 COG0001 YP_437631.1 COG0402 YP_437632.1 COG0477 YP_437633.1 COG0614 YP_437634.1 COG0609 YP_437635.1 COG4779 YP_437636.1 COG1120 YP_437637.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_437640.1 COG0596 YP_437641.1 COG3575 YP_437644.1 COG1331 YP_437645.1 COG0598 YP_437646.1 COG0596 YP_437647.1 COG1842 YP_437648.1 COG4298 YP_437650.1 COG0845 YP_437651.1 COG0841 YP_437652.1 COG2200 YP_437653.1 COG0500 YP_437654.1 COG2207 YP_437656.1 COG3789 YP_437657.1 COG1842 YP_437658.1 COG1226 YP_437660.1 COG3766 YP_437661.1 COG5463 YP_437662.1 COG0754 YP_437664.1 COG1638 YP_437665.1 COG3090 YP_437666.1 COG1593 YP_437667.1 COG0834 YP_437668.1 COG1047 YP_437670.1 COG3220 YP_437672.1 COG2982 YP_437673.1 COG1022 YP_437675.1 COG1028 YP_437676.1 COG0457 YP_437677.1 COG0745 YP_437678.1 COG0642 YP_437679.1 COG0491 YP_437680.1 COG0583 YP_437681.1 COG1595 YP_437682.1 COG3806 YP_437683.1 COG0154 YP_437684.1 COG1022 YP_437686.1 COG0583 YP_437688.1 COG1252 YP_437689.1 COG2862 YP_437691.1 COG0625 YP_437692.1 COG1028 YP_437693.1 COG0406 YP_437694.1 COG3173 YP_437695.1 COG1028 YP_437696.1 COG1960 YP_437697.1 COG0583 YP_437700.1 COG0603 YP_437701.1 COG0602 YP_437702.1 COG0679 YP_437703.1 COG0243 YP_437705.1 COG0596 YP_437706.1 COG0252 YP_437710.1 COG3727 YP_437711.1 COG0270 YP_437712.1 COG4360 YP_437713.1 COG0861 YP_437717.1 COG0642 YP_437719.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_437721.1 COG2133 YP_437723.1 COG0454 YP_437724.1 COG0697 YP_437725.1 COG1846 YP_437726.1 COG0834 YP_437727.1 COG2207 YP_437729.1 COG2321 YP_437732.1 COG1262 YP_437737.1 COG1409 YP_437738.1 COG3710 YP_437742.1 COG2827 YP_437743.1 COG0687 YP_437744.1 COG5001 YP_437745.1 COG0530 YP_437746.1 COG0639 YP_437747.1 COG0591 YP_437749.1 COG3264 YP_437751.1 COG0625 YP_437752.1 COG3915 YP_437753.1 COG0642 YP_437755.1 COG0031 YP_437757.1 catalyzes the formation of oxaloacetate from pyruvate YP_437758.1 biotin carboxylase; with subunit B, the carboxyltansferase/biotincarboxyl carrier subunit catalyzes the formation of oxaloacetate from pyruvate YP_437759.1 COG1116 YP_437760.1 COG0600 YP_437761.1 COG0715 YP_437762.1 COG1879 YP_437765.1 COG1446 YP_437770.1 COG1446 YP_437771.1 COG0840 YP_437773.1 COG5595 YP_437775.1 COG3128 YP_437776.1 COG0625 YP_437777.1 COG2378 YP_437778.1 Retron-type reverse transcriptase; COG3344 YP_437780.1 COG5083 YP_437781.1 COG0693 YP_437782.1 COG2942 YP_437783.1 COG0346 YP_437784.1 COG1733 YP_437785.1 COG0789 YP_437786.1 TIGRFAMsMatches:TIGR01511 YP_437787.1 COG4633 YP_437788.1 COG3019 YP_437790.1 COG4103 YP_437792.1 COG3344 YP_437794.1 COG0477 YP_437795.1 COG0583 YP_437800.1 COG0582 YP_437806.1 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases COG0847 YP_437813.1 TIGRFAMsMatches:TIGR01540 YP_437814.1 COG4373 YP_437816.1 TIGRFAMsMatches:TIGR01551 YP_437827.1 COG5283 YP_437829.1 COG3299 YP_437836.1 COG3501 YP_437839.1 COG0744 YP_437840.1 COG3405 YP_437843.1 COG3491 YP_437844.1 COG3558 YP_437845.1 COG1309 YP_437846.1 COG4969 YP_437847.1 TIGRFAMsMatches:TIGR00066 YP_437848.1 COG2207 YP_437849.1 COG3687 YP_437850.1 COG1846 YP_437852.1 COG3046 YP_437854.1 COG0454 YP_437855.1 COG0834 YP_437857.1 COG0583 YP_437858.1 COG3565 YP_437859.1 COG0111 YP_437860.1 COG4763 YP_437861.1 COG0834 YP_437862.1 COG2130 YP_437863.1 COG1028 YP_437865.1 COG0524 YP_437867.1 COG1879 YP_437870.1 COG3210 YP_437872.1 COG0534 YP_437873.1 COG1472 YP_437874.1 COG1609 YP_437875.1 COG0810 YP_437876.1 COG1120 YP_437877.1 COG0609 YP_437878.1 COG0614 YP_437880.1 COG1167 YP_437882.1 TIGRFAMsMatches:TIGR01122 YP_437884.1 COG0557 YP_437886.1 COG1994 YP_437888.1 TIGRFAMsMatches:TIGR00754 YP_437889.1 COG2906 YP_437897.1 COG0456 YP_437898.1 COG0589 YP_437899.1 COG4651 YP_437900.1 COG0474 YP_437901.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_437902.1 COG3978 YP_437903.1 COG1075 YP_437905.1 COG0515 YP_437906.1 COG0631 YP_437907.1 COG1716 YP_437916.1 COG3205 YP_437917.1 TIGRFAMsMatches:TIGR01341 YP_437922.1 COG4783 YP_437923.1 COG1739 YP_437928.1 COG0500 YP_437929.1 COG0846 YP_437930.1 COG0426 YP_437938.1 COG4728 YP_437939.1 COG0730 YP_437941.1 COG3738 YP_437943.1 COG4608 YP_437944.1 COG0444 YP_437945.1 COG1173 YP_437946.1 COG0601 YP_437947.1 COG0747 YP_437948.1 COG1609 YP_437949.1 COG3839 YP_437950.1 COG2723 YP_437951.1 COG0395 YP_437952.1 COG1175 YP_437953.1 COG1653 YP_437955.1 COG1609 YP_437956.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_437957.1 COG5640 YP_437959.1 COG0745 YP_437960.1 COG0642 YP_437961.1 COG1574 YP_437964.1 COG3291 YP_437965.1 COG2207 YP_437966.1 COG0300 YP_437970.1 COG0208 YP_437971.1 Catalyzes the rate-limiting step in dNTP synthesis YP_437974.1 Type II secretory pathway, component PulF COG1459 YP_437975.1 COG4969 YP_437976.1 COG2315 YP_437977.1 COG2808 YP_437978.1 COG1247 YP_437979.1 COG0834 YP_437980.1 COG2030 YP_437981.1 COG2199 YP_437982.1 COG1538 YP_437983.1 COG0841 YP_437984.1 COG0845 YP_437986.1 COG0583 YP_437988.1 COG0456 YP_437990.1 COG5640 YP_437992.1 COG2067 YP_437993.1 COG0739 YP_437996.1 COG5528 YP_437997.1 COG0702 YP_437998.1 COG1309 YP_437999.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_438000.1 TIGRFAMsMatches:TIGR00262 YP_438001.1 COG1671 YP_438002.1 COG1344 YP_438003.1 COG1349 YP_438004.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_438005.1 TIGRFAMsMatches:TIGR01311 YP_438006.1 COG3284 YP_438007.1 COG3839 YP_438008.1 COG3839 YP_438009.1 COG1175 YP_438010.1 COG0395 YP_438013.1 COG1653 YP_438014.1 COG0834 YP_438015.1 COG0811 YP_438016.1 COG0848 YP_438017.1 COG0810 YP_438018.1 COG2188 YP_438019.1 COG3839 YP_438020.1 COG0395 YP_438021.1 COG1175 YP_438022.1 COG1653 YP_438024.1 TIGRFAMsMatches:TIGR00502 YP_438025.1 COG2971 YP_438026.1 TIGRFAMsMatches:TIGR00221 YP_438027.1 COG2066 YP_438028.1 TIGRFAMsMatches:TIGR00484 YP_438032.1 COG1488 YP_438033.2 NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways YP_438034.1 COG3172 YP_438035.1 COG3201 YP_438036.1 COG1051 YP_438037.1 COG3236 YP_438039.1 COG0553 YP_438040.1 COG1397 YP_438041.1 COG3208 YP_438044.1 COG1701 YP_438045.1 COG0617 YP_438052.1 COG1132 YP_438057.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_438058.1 COG2020 YP_438062.1 COG0583 YP_438063.1 COG1266 YP_438064.1 COG0664 YP_438065.1 COG1266 YP_438068.1 COG2373 YP_438069.1 COG4953 YP_438074.1 COG5433 YP_438076.1 COG0286 YP_438078.1 COG1112 YP_438083.1 COG0175 YP_438084.1 COG0419 YP_438089.1 COG3293 YP_438095.1 COG5351 YP_438097.1 COG3501 YP_438098.1 COG3293 YP_438099.1 COG3293 YP_438103.1 Transposase and inactivated derivatives COG2801 YP_438105.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_438106.1 TIGRFAMsMatches:TIGR01173 YP_438107.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_438108.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_438109.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_438110.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_438111.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_438112.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_438113.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_438114.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_438115.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_438117.1 COG1475 YP_438118.1 ATPase involved in chromosome partitioning; COG1192 YP_438119.1 TIGRFAMsMatches:TIGR00138 YP_438120.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_438121.1 COG0834 YP_438122.1 COG2076 YP_438123.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_438124.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_438125.1 TIGRFAMsMatches:TIGR00188